• • DRAMP ID

  • DRAMP20818

• • Peptide Name

  • RR12Wpolar

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • RRLIWLILRLLR

• • Sequence Length

  • 12

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.26795535] Gram-positive bacteria:Bacillus subtilis lab strain (MIC=4μM), Staphylococcus aureus ATCC25923 (MIC=4μM), Streptococcus pyogenes ATCC19615 (MIC=4μM), Enterococcus feacalis ATCC29212 (MIC=8μM);
    • Gram-negative bacteria:Escherichia coli lab strain (MIC=8μM), Pseudomonas aeruginosa ATCC27853 (MIC=10μM), Klebsiella pneumoniae ATCC13883 (MIC=4μM), Salmonella enterica ATCC14028 (MIC=10μM)

• • Hemolytic Activity

  • • [Ref.26795535] 5% hemolysis at 5 μM, 12% hemolysis at 10 μM, 32% hemolysis at 25 μM, 60% hemolysis at 50 μM, 78% hemolysis at 100 μM against mice red cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20818.

DRAMP20818

• • Function

  • Antibacterial activity against the Gram-negative and Gram-positive bacteria

• ·Literature 1

• • Title

  • Salt-resistant short antimicrobial peptides

• • Pubmed ID

  • 26849911

• • Reference

  • Biopolymers. 2016 May;106(3):345-56.

• • Author

  • Mohanram H, Bhattacharjya S.