• DRAMP ID

    • DRAMP20823
    • Peptide Name

    • FV-CE (FV7 and CE(Cecropin A (1
    • Source

    • Synthetic construct
    • Family

    • FV7 and CE(Cecropin A (1
    • Gene

    • Not found
    • Sequence

    • FRIRVRVKWKLFKKI
    • Sequence Length

    • 15
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.28178190] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=8 μM), Streptococcus Faecalis ATCC 29212 (MIC=1 μM), Bacillus subtilis CMCC 63501 (MIC=1 μM), Staphylococcus epidermidis ATCC 12228 (MIC=0.5 μM);
      • Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=2 μM), Escherichia coli UB 1005 (MIC=2 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=2 μM), Pseudomonas aeruginosa PAO1 (MIC=2 μM), Salmonella typhimurium ATCC 14028 (MIC=4 μM), Salmonella typhimurium ATCC 7731 (MIC=4 μM).
    • Hemolytic Activity

      • [Ref.28178190] 1% hemolysis at 2 μM, 5% hemolysis at 128 μM against human red cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Random coil
    • Structure Description

    • The hybrid peptide displayed an unordered conformation in phosphate buffer.
    • Helical Wheel Diagram

    • DRAMP20823 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP20823.
    • Formula

    • C99H165N29O16
    • Absent Amino Acids

    • ACDEGHMNPQSTY
    • Common Amino Acids

    • K
    • Mass

    • 2017.58
    • PI

    • 12.31
    • Basic Residues

    • 7
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +7
    • Boman Index

    • -3583
    • Hydrophobicity

    • -0.213
    • Aliphatic Index

    • 116.67
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 392.86
    • Polar Residues

    • 0

DRAMP20823

    • Function

    • Antibacterial activity against the Gram-negative and Gram-positive bacteria
  • ·Literature 1
    • Title

    • High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
    • Reference

    • Int J Mol Sci. 2017 Feb 6;18(2).
    • Author

    • Tan T, Wu D, Li W, Zheng X, Li W, Shan A.