General Information
-
DRAMP ID
- DRAMP20823
-
Peptide Name
- FV-CE (FV7 and CE(Cecropin A (1
-
Source
- Synthetic construct
-
Family
- FV7 and CE(Cecropin A (1
-
Gene
- Not found
-
Sequence
- FRIRVRVKWKLFKKI
-
Sequence Length
- 15
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.28178190] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=8 μM), Streptococcus Faecalis ATCC 29212 (MIC=1 μM), Bacillus subtilis CMCC 63501 (MIC=1 μM), Staphylococcus epidermidis ATCC 12228 (MIC=0.5 μM);
- Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=2 μM), Escherichia coli UB 1005 (MIC=2 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=2 μM), Pseudomonas aeruginosa PAO1 (MIC=2 μM), Salmonella typhimurium ATCC 14028 (MIC=4 μM), Salmonella typhimurium ATCC 7731 (MIC=4 μM).
-
Hemolytic Activity
-
- [Ref.28178190] 1% hemolysis at 2 μM, 5% hemolysis at 128 μM against human red cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Random coil
-
Structure Description
- The hybrid peptide displayed an unordered conformation in phosphate buffer.
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20823.
Physicochemical Information
-
Formula
- C99H165N29O16
Absent Amino Acids
- ACDEGHMNPQSTY
Common Amino Acids
- K
Mass
- 2017.58
PI
- 12.31
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +7
-
Boman Index
- -3583
Hydrophobicity
- -0.213
Aliphatic Index
- 116.67
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 392.86
Polar Residues
- 0
DRAMP20823
Comments Information
Function
- Antibacterial activity against the Gram-negative and Gram-positive bacteria
Literature Information
- ·Literature 1
-
Title
- High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
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Pubmed ID
- 28178190
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Reference
- Int J Mol Sci. 2017 Feb 6;18(2).
-
Author
- Tan T, Wu D, Li W, Zheng X, Li W, Shan A.