General Information
-
DRAMP ID
- DRAMP20847
-
Peptide Name
- C1b(4-13)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- WRHWRRFWHR
-
Sequence Length
- 10
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=25μM);Pseudomonas aeruginosa(MIC=3.13μM);
- Gram-positive bacteria:Staphylococcus aureus(MIC= 50μM);B. cereus(MIC=6.25μM);S. lactis(MIC=6.25μM);E. faecalis (MIC=3.13μM);E. faecium(MIC=6.25μM)
-
Hemolytic Activity
-
- [Ref.27060618] HC50>500μM against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Random coil conformation
-
Structure Description
- The peptide adopts 65.69% alpha-helical
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20847.
Physicochemical Information
-
Formula
- C78H103N29O11
Absent Amino Acids
- ACDEGIKLMNPQSTVY
Common Amino Acids
- R
Mass
- 1622.86
PI
- 12.48
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +6
-
Boman Index
- -5903
Hydrophobicity
- -2.43
Aliphatic Index
- 0
Half Life
-
- Mammalian:2.8 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 16500
Absorbance 280nm
- 1833.33
Polar Residues
- 0
DRAMP20847
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- Structure-activity analysis and biological studies of chensinin-8b analogues.
-
Pubmed ID
- 27060618
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Reference
- Acta Biomater. 2016 Jun;37:59-68.
-
Author
- Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D.