• DRAMP ID

    • DRAMP20850
    • Peptide Name

    • [K4,K10]C1b(3-13)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • VWRKWRRFWKR
    • Sequence Length

    • 11
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=3.13μM);Pseudomonas aeruginosa(MIC=1.56μM);
      • Gram-positive bacteria:Staphylococcus aureus(MIC= 6.25μM);B. cereus(MIC=3.13μM);S. lactis(MIC=6.25μM);E. faecalis (MIC=6.25μM);E. faecium(MIC=6.25μM)
    • Hemolytic Activity

      • [Ref.27060618] HC50>500μM against human red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Random coil conformation
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP20850 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP20850.
    • Formula

    • C83H122N28O12
    • Absent Amino Acids

    • ACDEGHILMNPQSTY
    • Common Amino Acids

    • R
    • Mass

    • 1704.06
    • PI

    • 12.48
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Net Charge

    • +6
    • Boman Index

    • -5677
    • Hydrophobicity

    • -1.955
    • Aliphatic Index

    • 26.36
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 16500
    • Absorbance 280nm

    • 1650
    • Polar Residues

    • 0

DRAMP20850

    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria.
  • ·Literature 1
    • Title

    • Structure-activity analysis and biological studies of chensinin-11b analogues.
    • Reference

    • Acta Biomater. 2016 Jun;37:59-68.
    • Author

    • Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D.