• DRAMP ID

    • DRAMP20855
    • Peptide Name

    • Api793 apidaecin petide derivative
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • OWOWORPVYOPRPRPPHPRL
    • Sequence Length

    • 20
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=8μg/mL);K. pneumoniae (DSM 681)(MIC=16μg/mL);
      • Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=16μg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>16μg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>8μg/mL);
      • Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>64μg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>256μg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>64μg/mL);Rat cardiomyocytes(IC50>0.6g/L);HEK293 cells(IC50=0.64 ± 0.05g/L);HeLa cells(IC50=0.64 ± 0.05g/L)
    • Hemolytic Activity

      • [Ref.27243004] 1.3 ± 0.4% hemolysis at 0.1 g/L; 1.6 ± 0.5% hemolysis at 0.6 g/L against human red blood cells
    • Cytotoxicity

      • [Ref.27243004] IC50 > 0.6 g/L against Rat cardiomyocytes.
      • IC50 = 0.64 ± 0.05 g/L against HEK293. IC50 = 0.64 ± 0.15 g/L against HeLa.
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • The 'O' in sequence is Ornithine
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP20855 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP20855.
    • Formula

    • Absent Amino Acids

    • Common Amino Acids

    • Mass

    • 3059.71
    • PI

    • 12
    • Basic Residues

    • Acidic Residues

    • Hydrophobic Residues

    • Net Charge

    • Boman Index

    • 0
    • Hydrophobicity

    • 0
    • Aliphatic Index

    • 0
    • Half Life

      • Mammalian:
      • Yeast:
      • E.coli:
    • Extinction Coefficient Cystines

    • Absorbance 280nm

    • 0
    • Polar Residues

DRAMP20855

DRAMP20855 chydropathy plot
    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria.
  • ·Literature 1
    • Title

    • N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
    • Reference

    • Front Cell Dev Biol. 2016 May 10;4:39.
    • Author

    • Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R.