General Information
-
DRAMP ID
- DRAMP20858
-
Peptide Name
- Api796 apidaecin petide derivative
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- OIOIOIORPVYOPRPRPPHPRL
-
Sequence Length
- 22
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=8μg/mL);K. pneumoniae (DSM 681)(MIC=16μg/mL);
- Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=8μg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>16μg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>16μg/mL);
- Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>64μg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>128μg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>128μg/mL);Rat cardiomyocytes(IC50>0.6g/L);HEK293 cells(IC50>0.6g/L);HeLa cells(IC50>0.6g/L)
-
Hemolytic Activity
-
- [Ref.27243004] 0.8 ± 0.2% hemolysis at 0.1 g/L;μ0.1 ± 0.8 % hemolysis at 0.6 g/L against human red blood cells
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Cytotoxicity
-
- [Ref.27243004] IC50 > 0.6 g/L against Rat cardiomyocytes.
- IC50 > 0.6g/L against HEK293. IC50 > 0.6g/L against HeLa.
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- The 'O' in sequence is Ornithine
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20858.
Physicochemical Information
-
Formula
Absent Amino Acids
Common Amino Acids
Mass
- 3264.06
PI
- 12
Basic Residues
Acidic Residues
Hydrophobic Residues
Net Charge
-
Boman Index
- 0
Hydrophobicity
- 0
Aliphatic Index
- 0
Half Life
-
- Mammalian:
- Yeast:
- E.coli:
Extinction Coefficient Cystines
Absorbance 280nm
- 0
Polar Residues
DRAMP20858
Comments Information
Function
- Antibacterial activity against the Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
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Pubmed ID
- 27243004
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Reference
- Front Cell Dev Biol. 2016 May 10;4:39.
-
Author
- Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R.