General Information

    • DRAMP ID

    • DRAMP20924

    • Peptide Name

    • Myxinidin (S12)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIHDILKYGKPA

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC >50 microM), Pseudomonas aeruginosa (MIC >50 microM), S. Salmonella typhimurium (MIC >50 microM), Klebsiella pneumoniae (MIC =30 microM) ;
      • Gram-positive bacteria: Staphylococcus aureus (MIC >50 microM)

    • Hemolytic Activity

      • [Ref.24957834] Some peptides at 50 μM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 μM and 200 μM peptide.

    • Cytotoxicity

      • [Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 7%, 14.9% and 19.9% at peptide concentrations of 1, 20, 50, 100 and 200 μM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20924 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20924.

Physicochemical Information

    • Formula

    • C61H98N16O16

    • Absent Amino Acids

    • CEFMNQRSTVW

    • Common Amino Acids

    • GIK

    • Mass

    • 1311.55

    • PI

    • 8.51

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +2

    • Boman Index

    • -617

    • Hydrophobicity

    • -0.3

    • Aliphatic Index

    • 105.83

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 135.45

    • Polar Residues

    • 3

DRAMP20924

Comments Information

    • Function

    • Antibacterial activity against the Gram-nagative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Structural insights into and activity analysis of the antimicrobial peptide myxinidin.

    • Reference

    • Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90.

    • Author

    • Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S.