• • DRAMP ID

  • DRAMP20937

• • Peptide Name

  • Pb-CATH3

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • HRVKRNGFRKFMRRLKKFFAGG

• • Sequence Length

  • 22

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.28630199] Gram-positive bacteria: B. cereus ATCC 10876 (MIC=32 μg/ml);
    • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 μg/ml), S. typhimurium ATCC 14028 (MIC=2 μg/ml);
    • Clinical isolates: Escherichia coli (4.7 μg/ml), K. pneumoniae (1.18 μg/ml)

• • Hemolytic Activity

  • • [Ref.28630199]0% hemolysis at 8 μg/ml, 1.7 ± 0.5% hemolysis at 16 μg/ml, 3.1 ± 0.5% hemolysis at 32 μg/ml, 4.0 ± 0.2% hemolysis at 64 μg/ml against chicken red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20937.

DRAMP20937

• • Function

  • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.

• ·Literature 1

• • Title

  • Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity

• • Pubmed ID

  • 28630199

• • Reference

  • Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00530-17.

• • Author

  • Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C.