• DRAMP ID

    • DRAMP20940
    • Peptide Name

    • Polybia-MP1S-Q12K
    • Source

    • Synthetic construct
    • Family

    • Derived from Polybia-MP1
    • Gene

    • Not found
    • Sequence

    • IDWKKLLDAAKKIL
    • Sequence Length

    • 14
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • [Ref.29075946] Gram-positive bacteria: Bacillus subtilis (MIC=0.8 μM), Staphylococcus aureus (MIC=1.2 μM), Staphylococcus epidermidis (MIC=50 μM)
    • Hemolytic Activity

      • [Ref.29075946]9.6% hemolysis at 12.5μM,13.9% hemolysis at 25μM against human red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • The oct-4-enyl hydrocarbon staple between Leu6 and Ala10
    • Stereochemistry

    • L
    • Structure

    • Alpha helix
    • Structure Description

    • The peptide adopts a conformational structure with 81.8% alpha helix in the aqueous solution.
    • Helical Wheel Diagram

    • DRAMP20940 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP20940.
    • Formula

    • C79H135N19O19
    • Absent Amino Acids

    • CEFGHMNPQRSTVY
    • Common Amino Acids

    • K
    • Mass

    • 1655.06
    • PI

    • 9.53
    • Basic Residues

    • 4
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +2
    • Boman Index

    • -909
    • Hydrophobicity

    • 0.036
    • Aliphatic Index

    • 153.57
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 423.08
    • Polar Residues

    • 0

DRAMP20940

    • Function

    • Antibacterial activity against the Gram-positive bacteria, position 6 and 10 are cross-linked residues connected by the oct-4-enyl hydrocarbon staple
  • ·Literature 1
    • Title

    • Antimicrobial activity and stability of stapled helices of polybia-MP1
    • Reference

    • Arch Pharm Res. 2017 Dec;40(12):1414-1422.
    • Author

    • Luong HX, Kim DH, Lee BJ, Kim YW