• DRAMP ID

    • DRAMP21084
    • Peptide Name

    • ccTP 6 (Derived from TP2)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GWCRCVCRRGICRCFCRK
    • Sequence Length

    • 18
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic form
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.10673369] Gram-positive bacteria : Staphylococcus aureus(MIC=1.7 μM(low-salt);MIC=0.7 μM(high-salt)), Micrococcus luteus(MIC=0.3 μM(low-salt);MIC=0.4 μM(high-salt)), Enterococcus faecalis(MIC=1.4 μM(low-salt);MIC=1.2 μM(high-salt));
      • Gram-negative bacteria : Escherichia coli(MIC=6.1 μM(low-salt);MIC=1.2 μM(high-salt)), Pseudomonas aeruginosa(MIC=2.0 μM(low-salt);MIC=4.7 μM(high-salt)), Primula vulgaris(MIC=17.0 μM(low-salt);MIC=39.8 μM(high-salt)), Klebsiella oxytoca(MIC=4.1 μM(low-salt);MIC=4.1 μM(high-salt));
      • Fungi : Candida albicans(MIC=10.5 μM(low-salt);MIC=5.2 μM(high-salt)), Candida kefyr(MIC=1.1 μM(low-salt);MIC=0.7 μM(high-salt)), Candida tropicalis(MIC=2.3 μM(low-salt);MIC=1.9 μM(high-salt))
    • Hemolytic Activity

      • [Ref.10673369] EC25=3900 μM against human red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation (Gly18)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys3 and Cys16, Cys5 and Cys14, Cys7 and Cys12.
    • Stereochemistry

    • L
    • Structure

    • Beta tile
    • Structure Description

    • Although there is insufficient information to deconvolute these CD spectra of these two-b-strand cyclic cystine-knot structures due to the various contributions by
    • Helical Wheel Diagram

    • DRAMP21084 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP21084.
    • Formula

    • C89H149N35O19S6
    • Absent Amino Acids

    • ADEHLMNPQSTY
    • Common Amino Acids

    • C
    • Mass

    • 2205.75
    • PI

    • 9.57
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +6
    • Boman Index

    • -5632
    • Hydrophobicity

    • -0.089
    • Aliphatic Index

    • 37.78
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5875
    • Absorbance 280nm

    • 345.59
    • Polar Residues

    • 8

DRAMP21084

DRAMP21084 chydropathy plot
    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida kefyr, Candida tropicalis
  • ·Literature 1
    • Title

    • Marked Increase in Membranolytic Selectivity of Novel Cyclic Tachyplesins Constrained with an Antiparallel Two-b Strand Cystine Knot Framework
    • Reference

    • Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.
    • Author

    • James P. Tam, Yi-An Lu, and Jin-Long Yang