• DRAMP ID

    • DRAMP21087
    • Peptide Name

    • PR-PG (Derived from PRW4)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RFRRLRWKTRWRLKKICYCRRRFCVCV
    • Sequence Length

    • 27
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic form
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.25818457] Gram-positive bacteria : Staphylococcus aureus 25923(MIC=29.6 mg/L), Staphylococcus aureus 29213(MIC=7.4 mg/L), Staphylococcus epidermidis 12228(MIC=7.4 mg/L), Enterococcus faecalis 29212(MIC=3.7 mg/L), Bacillus subtilis 11060(MIC=7.4 mg/L);
      • Gram-negative bacteria : Escherichia coli 078(MIC=14.8 mg/L), Escherichia coli K88(MIC=1.9 mg/L), Escherichia coli ER2566(MIC=3.7 mg/L), Escherichia coli 44102(MIC=1.9 mg/L), Escherichia coli 1515(MIC=14.8 mg/L), Escherichia coli 25922(MIC=3.7 mg/L), Escherichia coli UB1005(MIC=7.4 mg/L), Salmonella typhimurium 7731(MIC=14.8 mg/L), Salmonella typhimurium 1402(MIC=7.4 mg/L), Pseudomonas aeruginosa 21625(MIC=14.8 mg/L), Pseudomonas aeruginosa 21630(MIC=7.4 mg/L), Pseudomonas aeruginosa 10419(MIC=14.8 mg/L), Pseudomonas aeruginosa 27853(MIC=14.8 mg/L), Salmonella pullorum 7913(MIC=14.8 mg/L)
    • Hemolytic Activity

      • [Ref.25818457] 0.5% hemolysis at 1.1 mg/L , 2% hemolysis at 2.3 mg/L , 10% hemolysis at 4.6 mg/L , 23% hemolysis at 9.2 mg/L , 30% hemolysis at 18.4 mg/L , 45% hemolysis at 36.8mg/L , 46% hemolysis at 73.6 mg/L , 47% hemolysis at 147.1 mg/L , 50% hemolysis at 294.3 mg/L against human red blood cells
    • Cytotoxicity

      • [Ref.25818457] The cell viability of PR-FG is 92.7%, 76%, 64%, 58%, 53%, 43%, 39%, 37% and 34% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 μg/ml.
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Random coil, alpha helix, beta Sheet
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP21087 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP21087.
    • Formula

    • C165H271N59O30S4
    • Absent Amino Acids

    • ADEGHMNPQS
    • Common Amino Acids

    • R
    • Mass

    • 3689.58
    • PI

    • 11.72
    • Basic Residues

    • 12
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +12
    • Boman Index

    • -11506
    • Hydrophobicity

    • -0.737
    • Aliphatic Index

    • 64.81
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 12740
    • Absorbance 280nm

    • 490
    • Polar Residues

    • 6

DRAMP21087

DRAMP21087 chydropathy plot
    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
  • ·Literature 1
    • Title

    • Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of a-helix-based peptide amphiphiles
    • Reference

    • Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.
    • Author

    • Zhi Ma, Dandan Wei, Ping Yan, Xin Zhu, Anshan Shan , Zhongpeng Bi