• DRAMP ID

    • DRAMP21089
    • Peptide Name

    • C4 (Derived from PRW4)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RFRRLRCKTRCRLKKI
    • Sequence Length

    • 16
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic form
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>128 μM), Staphylococcus epidermidis 12228(MIC>128 μM), Enterococcus faecalis 29212(MIC>128 μM);
      • Gram-negative bacteria : Escherichia coli 25922(MIC=2 μM), Escherichia coli 1005(MIC>128 μM), Salmonella typhimurium 7731(MIC128 μM)
    • Hemolytic Activity

      • [Ref.25735802] MHC5>256 μM against human red blood cells
    • Cytotoxicity

      • [Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 μM.
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Alpha helix
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP21089 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP21089.
    • Formula

    • C91H169N37O18S2
    • Absent Amino Acids

    • ADEGHMNPQSVWY
    • Common Amino Acids

    • R
    • Mass

    • 2133.7
    • PI

    • 12.01
    • Basic Residues

    • 9
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +9
    • Boman Index

    • -8844
    • Hydrophobicity

    • -1.219
    • Aliphatic Index

    • 73.13
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 8.33
    • Polar Residues

    • 3

DRAMP21089

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
  • ·Literature 1
    • Title

    • Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different α-helical propensity
    • Reference

    • Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.
    • Author

    • Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan