• DRAMP ID

    • DRAMP21090
    • Peptide Name

    • D4 (Derived from PRW4)
    • Source

    • Synthetic construct
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • RFRRLRDKTRDRLKKI
    • Sequence Length

    • 16
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>128 μM), Staphylococcus epidermidis 12228(MIC>128 μM), Enterococcus faecalis 29212(MIC>128 μM);
      • Gram-negative bacteria : Escherichia coli 25922(MIC>128 μM), Escherichia coli 1005(MIC>128 μM), Salmonella typhimurium 7731(MIC>128 μM)
    • Hemolytic activity

      • [Ref.25735802] MHC5>256 μM against human red blood cells
    • Binding Target

    • Unknown
    • Structure

    • Alpha helix
    • Structure Description

    • Unknown
    • DRAMP21090 helical wheel diagram
    • Formula

    • C93H169N37O22
    • Absent Amino Acids

    • ACEGHMNPQSVWY
    • Common Amino Acids

    • R
    • Mass

    • 2157.6
    • PI

    • 12.01
    • Basic Residues

    • 9
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 4
    • Boman Index

    • -10844
    • Hydrophobicity

    • -196.88
    • Aliphatic Index

    • 73.13
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 1

DRAMP21090

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
  • Literature 1
    • Reference

    • Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.
    • Author

    • Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan
    • Title

    • Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different α-helical propensity