General Information
-
DRAMP ID
- DRAMP21107
-
Peptide Name
- Feleucin-BO1 (toads, amphibians, animals)
-
Source
- Asian bombinid toad species, Bombina orientalis
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- FLGLLGSLL
-
Sequence Length
- 9
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
-
Target Organism
-
- [Ref.25056849] Gram-positive bacteria : Staphylococcus aureus(MIC=3 μM, MBC=6 μM);
- Gram-negative bacteria : Escherichia coli(MIC=12 μM, MBC=25 μM);
- Fungi : Candida albicans(MIC=6 μM, MBC=12 μM)
-
Hemolytic Activity
-
- [Ref.25056849] 100% hemolysis at 80 mg/L against horse red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
-
Structure Description
- The Phe (F) and Leu (L) residue side-chains are oriented on one side of the peptide In feleucin-BO1, while the short side-chains of the hydrophilic Gly (G) and Ser (S) residues are oriented on the other.
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21107.
Physicochemical Information
-
Formula
- C46H77N9O11
Absent Amino Acids
- ACDEHIKMNPQRTVWY
Common Amino Acids
- L
Mass
- 932.17
PI
- 5.52
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- 0
-
Boman Index
- 2606
Hydrophobicity
- 2.244
Aliphatic Index
- 216.67
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP21107
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans
Literature Information
- ·Literature 1
-
Title
- Feleucin-BO1: A Novel Antimicrobial Non-Apeptide Amide from the Skin Secretion of the Toad, Bombina orientalis, and Design of a Potent Broad-Spectrum Synthetic Analogue, Feleucin-K3
-
Pubmed ID
- 25056849
-
Reference
- Chem Biol Drug Des. 2015 Mar;85(3):259-67. doi: 10.1111/cbdd.12396.
-
Author
- Xiaojuan Hou, Qiang Du, Renjie Li, Mei Zhou, Hui Wang, Lei Wang, Can Guo, Tianbao Chen and Chris Shaw