• DRAMP ID

    • DRAMP21136
    • Peptide Name

    • P8 (Derived from P5)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • HRWWRWWRH
    • Sequence Length

    • 9
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic form
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=1 μM, MBC=1 μM), Staphylococcus aureus(MIC=16 μM, MBC=32 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=8 μM, MBC=32 μM)
    • Hemolytic Activity

      • [Ref.28372989] MHC5=86.67 μM against human red blood cells
    • Cytotoxicity

      • [Ref.28372989] IC50 > 86.67 μM for hPBMCs. The cell viability of hPBMCs is 96%, 98.4%, 86.8%, 84.8% and 88.8% and at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 μM.
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP21136 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP21136.
    • Formula

    • C74H92N26O10
    • Absent Amino Acids

    • ACDEFGIKLMNPQSTVY
    • Common Amino Acids

    • W
    • Mass

    • 1505.71
    • PI

    • 12.3
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +5
    • Boman Index

    • -4476
    • Hydrophobicity

    • -2.611
    • Aliphatic Index

    • 0
    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 22000
    • Absorbance 280nm

    • 2750
    • Polar Residues

    • 0

DRAMP21136

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
  • ·Literature 1
    • Title

    • Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
    • Reference

    • Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.
    • Author

    • Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M