General Information

    • DRAMP ID

    • DRAMP21138

    • Peptide Name

    • GNU6 (De novo synthesis)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RIIRPIIQIIKQKIR

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.23946320] Gram-positive bacteria : Bacillus subtilis(MIC=2 mg/L), Enterococcus faecalis(MIC=2 mg/L), Micrococcus luteus(MIC=2 mg/L), Staphylococcus aureus(MIC=2 mg/L);
      • Gram-negative bacteria : Escherichia coli(MIC=4 mg/L), Pseudomonas aeruginosa(MIC=2 mg/L), Salmonella typhimurium(MIC=4 mg/L);
      • Fungi : Candida albicans(MIC=2 mg/L), Cryptococcus neoformans(MIC=2 mg/L), Saccharomyces cerevisiae(MIC=4 mg/L)

    • Hemolytic Activity

      • [Ref.23946320] 0% hemolysis at 140 mg/L against human red blood cells

    • Cytotoxicity

      • [Ref.23946320] The cell viability of hPBMCs is 102.6%, 102.6%, 107.9%, 96.8% and 97.9% at peptide concentrations of 4, 8, 16, 32, 64 μg/ml

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21138 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21138.

Physicochemical Information

    • Formula

    • C87H162N28O18

    • Absent Amino Acids

    • ACDEFGHLMNSTVWY

    • Common Amino Acids

    • I

    • Mass

    • 1888.42

    • PI

    • 12.31

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +5

    • Boman Index

    • -3250

    • Hydrophobicity

    • 0.107

    • Aliphatic Index

    • 182

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21138

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae

Literature Information

  • ·Literature 1

    • Title

    • De novo generation of short antimicrobial peptides with enhanced stability and cell specificity

    • Reference

    • J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.

    • Author

    • Hyun Kim, Ju Hye Jang, Sun Chang Kim and Ju Hyun Cho