General Information
-
DRAMP ID
- DRAMP21143
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Peptide Name
- Myxinidin1 (Derived from Myxinidin)
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Source
- Synthetic construct
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Family
- Not found
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Gene
- Not found
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Sequence
- GIHHILKYGKPS
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Sequence Length
- 12
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic form
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.26450121] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC>32 μM), Staphylococcus aureus CCARM 3114(MIC>32 μM), Staphylococcus aureus CCARM 3709(MIC>32 μM), Listeria monocytogenes (KCTC 3710)(MIC>32 μM);
- Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC>32 μM), Escherichia coli CCARM 1229(MIC>32 μM), Escherichia coli CCARM 1238(MIC>32 μM), Salmonella typhimurium (KCTC 1926)(MIC>32 μM), Salmonella typhimurium CCARM 8009(MIC>32 μM), Salmonella typhimurium CCARM 8013(MIC>32 μM), Pseudomonas aeruginosa (ATCC 27853)(MIC>32 μM), Pseudomonas aeruginosa 3592(MIC>32 μM), Pseudomonas aeruginosa 5018(MIC>32 μM)
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Hemolytic Activity
-
- [Ref.26450121] 0% hemolysis at 50 μM , 0% hemolysis at 100 μM , 0% hemolysis at 200 μM , 0% hemolysis at 400 μM against human red blood cells
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Cytotoxicity
-
- [Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 μM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Linear
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N-terminal Modification
- Free
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C-terminal Modification
- Free
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Nonterminal Modifications and Unusual Amino Acids
- None
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Stereochemistry
- L
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
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PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21143.
Physicochemical Information
-
Formula
- C63H100N18O15
Absent Amino Acids
- ACDEFMNQRTVW
Common Amino Acids
- GHIK
Mass
- 1349.6
PI
- 9.7
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 3
Net Charge
- +4
-
Boman Index
- -732
Hydrophobicity
- -0.492
Aliphatic Index
- 97.5
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 135.45
Polar Residues
- 4
DRAMP21143
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
Literature Information
- ·Literature 1
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Title
- Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties.
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Pubmed ID
- 26450121
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Reference
- Amino Acids. 2016 Feb;48(2):505-22. doi: 10.1007/s00726-015-2104-0.
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Author
- Han HM, Gopal R, Park Y