General Information

    • DRAMP ID

    • DRAMP21145

    • Peptide Name

    • Myxinidin3 (Derived from Myxinidin)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RIRWILRYWRWS

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.26450121] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=1 μM), Staphylococcus aureus CCARM 3114(MIC=8 μM), Staphylococcus aureus CCARM 3709(MIC=2 μM), Listeria monocytogenes (KCTC 3710)(MIC=4 μM);
      • Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2 μM), Escherichia coli CCARM 1229(MIC=1 μM), Escherichia coli CCARM 1238(MIC=2 μM), Salmonella typhimurium (KCTC 1926)(MIC=2 μM), Salmonella typhimurium CCARM 8009(MIC=4 μM), Salmonella typhimurium CCARM 8013(MIC=4 μM), Pseudomonas aeruginosa (ATCC 27853)(MIC=4 μM), Pseudomonas aeruginosa 3592(MIC=8 μM), Pseudomonas aeruginosa 5018(MIC=8 μM)

    • Hemolytic Activity

      • [Ref.26450121] 27% hemolysis at 50 μM , 45% hemolysis at 100 μM , 63% hemolysis at 200 μM , 59% hemolysis at 400 μM against human red blood cells

    • Cytotoxicity

      • [Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 μM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Beta Sheet

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21145 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21145.

Physicochemical Information

    • Formula

    • C87H127N27O15

    • Absent Amino Acids

    • ACDEFGHKMNPQTV

    • Common Amino Acids

    • R

    • Mass

    • 1791.14

    • PI

    • 12

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -4147

    • Hydrophobicity

    • -0.833

    • Aliphatic Index

    • 97.5

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 17990

    • Absorbance 280nm

    • 1635.45

    • Polar Residues

    • 2

DRAMP21145

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties.

    • Reference

    • Amino Acids. 2016 Feb;48(2):505-22. doi: 10.1007/s00726-015-2104-0.

    • Author

    • Han HM, Gopal R, Park Y