General Information
-
DRAMP ID
- DRAMP21154
-
Peptide Name
- HYL (Bee, Insecta, Animals)
-
Source
- Solitary wild bee Hylaeus signatus
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GIMSSLMKKLAAHIAK
-
Sequence Length
- 16
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=63 μM), Staphylococcus epidermidis(MIC=13 μM);
- Gram-negative bacteria : Escherichia coli(MIC=15 μM), Pseudomonas aeruginosa 5482(MIC=20 μM);
- Fungi : Candida albicans(MIC=18 μM)
-
Hemolytic Activity
-
- [Ref.26998557] LC50>400 μM against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21154.
Physicochemical Information
-
Formula
- C75H135N21O19S2
Absent Amino Acids
- CDEFNPQRTVWY
Common Amino Acids
- AK
Mass
- 1699.15
PI
- 10.3
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +4
-
Boman Index
- 264
Hydrophobicity
- 0.556
Aliphatic Index
- 116.25
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP21154
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans
Literature Information
- ·Literature 1
-
Title
- Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
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Pubmed ID
- 26998557
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Reference
- J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.
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Author
- Nešuta O, Hexnerová R, Buděšínský M, Slaninová J, Bednárová L, Hadravová R, Straka J, Veverka V, Čeřovský V