General Information
-
DRAMP ID
- DRAMP21160
-
Peptide Name
- HYL-6 (Derived from HYL)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GIMSSLMKKLAAIIAK
-
Sequence Length
- 16
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=7.2 μM), Staphylococcus epidermidis(MIC=5 μM);
- Gram-negative bacteria : Escherichia coli(MIC=3.6 μM), Pseudomonas aeruginosa 5482(MIC=8 μM);
- Fungi : Candida albicans(MIC=8.4 μM)
-
Hemolytic Activity
-
- [Ref.26998557] LC50=93 μM against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21160.
Physicochemical Information
-
Formula
- C75H139N19O19S2
Absent Amino Acids
- CDEFHNPQRTVWY
Common Amino Acids
- AIK
Mass
- 1675.16
PI
- 10.3
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +4
-
Boman Index
- 1222
Hydrophobicity
- 1.038
Aliphatic Index
- 140.63
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP21160
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans
Literature Information
- ·Literature 1
-
Title
- Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
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Pubmed ID
- 26998557
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Reference
- J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.
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Author
- Nešuta O, Hexnerová R, Buděšínský M, Slaninová J, Bednárová L, Hadravová R, Straka J, Veverka V, Čeřovský V