• DRAMP ID

    • DRAMP21160
    • Peptide Name

    • HYL-6 (Derived from HYL)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GIMSSLMKKLAAIIAK
    • Sequence Length

    • 16
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic form
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=7.2 μM), Staphylococcus epidermidis(MIC=5 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=3.6 μM), Pseudomonas aeruginosa 5482(MIC=8 μM);
      • Fungi : Candida albicans(MIC=8.4 μM)
    • Hemolytic Activity

      • [Ref.26998557] LC50=93 μM against human red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP21160 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP21160.
    • Formula

    • C75H139N19O19S2
    • Absent Amino Acids

    • CDEFHNPQRTVWY
    • Common Amino Acids

    • AIK
    • Mass

    • 1675.16
    • PI

    • 10.3
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +4
    • Boman Index

    • 1222
    • Hydrophobicity

    • 1.038
    • Aliphatic Index

    • 140.63
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP21160

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans
  • ·Literature 1
    • Title

    • Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
    • Reference

    • J Nat Prod. 2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.
    • Author

    • Nešuta O, Hexnerová R, Buděšínský M, Slaninová J, Bednárová L, Hadravová R, Straka J, Veverka V, Čeřovský V