• • DRAMP ID

  • DRAMP21215

• • Peptide Name

  • IK4-all D (Derived from IK8-all L)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • irik

• • Sequence Length

  • 4

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC>500 mg/L), Staphylococcus aureus(MIC>500 mg/L);
    • Gram-negative bacteria : Escherichia coli(MIC>500 mg/L), Pseudomonas aeruginosa(MIC>500 mg/L);
    • Fungi : Candida albicans(MIC>500 mg/L)

• • Hemolytic Activity

  • • [Ref.24211081] HC10>2000 mg/L against rabbit red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • D

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP21215.

DRAMP21215

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

• ·Literature 1

• • Title

  • Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles.

• • Pubmed ID

  • 24211081

• • Reference

  • Biomaterials. 2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.

• • Author

  • Ong ZY, Cheng J, Huang Y, Xu K, Ji Z, Fan W, Yang YY