General Information
-
DRAMP ID
- DRAMP21217
-
Peptide Name
- IK8-2D (Derived from IK8-all L)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- IRIkIrIK
-
Sequence Length
- 8
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=3.9 mg/L), Staphylococcus aureus(MIC=31.3 mg/L);
- Gram-negative bacteria : Escherichia coli(MIC=15.6 mg/L), Pseudomonas aeruginosa(MIC=7.8 mg/L);
- Fungi : Candida albicans(MIC=3.9 mg/L)
-
Hemolytic Activity
-
- [Ref.24211081] HC10=1600 mg/L against rabbit red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- Mixed (D-Lys4, D-Arg6)
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21217.
Physicochemical Information
-
Formula
- C36H66N10O5
Absent Amino Acids
- ACDEFGHLMNPQSTVWY
Common Amino Acids
- I
Mass
- 1039.38
PI
- 12.02
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +2
-
Boman Index
- -79
Hydrophobicity
- 1.2
Aliphatic Index
- 195
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP21217
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans
Literature Information
- ·Literature 1
-
Title
- Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles.
-
Pubmed ID
- 24211081
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Reference
- Biomaterials. 2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.
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Author
- Ong ZY, Cheng J, Huang Y, Xu K, Ji Z, Fan W, Yang YY