General Information

    • DRAMP ID

    • DRAMP21218

    • Peptide Name

    • IK12-all L (De novo synthesis)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IRVKIRVKIRVK

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=2.0 mg/L), Staphylococcus aureus(MIC=31.3 mg/L);
      • Gram-negative bacteria : Escherichia coli(MIC=15.6 mg/L), Pseudomonas aeruginosa(MIC=62.5 mg/L);
      • Fungi : Candida albicans(MIC=125 mg/L)

    • Hemolytic Activity

      • [Ref.24211081] HC10>125 mg/L against rabbit red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Beta sheet

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21218 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21218.

Physicochemical Information

    • Formula

    • C69H134N24O13

    • Absent Amino Acids

    • ACDEFGHLMNPQSTWY

    • Common Amino Acids

    • IKRV

    • Mass

    • 1507.98

    • PI

    • 12.31

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +6

    • Boman Index

    • -3453

    • Hydrophobicity

    • 0.075

    • Aliphatic Index

    • 170

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21218

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles.

    • Reference

    • Biomaterials. 2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.

    • Author

    • Ong ZY, Cheng J, Huang Y, Xu K, Ji Z, Fan W, Yang YY