General Information

    • DRAMP ID

    • DRAMP21224

    • Peptide Name

    • TPk (Derived from TP)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VRRPkWWWkFLRR

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.17604338] Gram-positive bacteria : Staphylococcus epidermidis(KCTC 1917)(MIC=1 μM), Staphylococcus aureus(KCTC 1621)(MIC=1 μM), MRSA1 (CCARM 3001)(MIC=1 μM), MRSA2 (CCARM 3543)(MIC=0.5 μM);
      • Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=2 μM), Pseudomonas aeruginosa(KCTC 1637)(MIC=4 μM), MDRPA1 (CCARM 2095)(MIC=4 μM), MDRPA2 (CCARM 2109)(MIC=8 μM)

    • Hemolytic Activity

      • [Ref.17604338] MHC10>200 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • The 'k' in sequence is lysine peptoid residue [NH2-(CH2)4-NH-CH2-COOH]

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21224 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21224.

Physicochemical Information

    • Formula

    • C82H112N26O10

    • Absent Amino Acids

    • ACDEGHIKMNQSTY

    • Common Amino Acids

    • R

    • Mass

    • 1914.34

    • PI

    • 12.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -4075

    • Hydrophobicity

    • -0.885

    • Aliphatic Index

    • 52.31

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 16500

    • Absorbance 280nm

    • 1375

    • Polar Residues

    • 0

DRAMP21224

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Cathelicidin-derived Trp/Pro-rich antimicrobial peptides with lysine peptoid residue (Nlys): therapeutic index and plausible mode of action.

    • Reference

    • J Pept Sci. 2007 Aug;13(8):529-35.

    • Author

    • Zhu WL, Hahm KS, Shin SY