• DRAMP ID

    • DRAMP21231
    • Peptide Name

    • S-6K-F17-3GN (Derived from S-6K-F17)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • KKKKKKNGFAAWGAFGA
    • Sequence Length

    • 17
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic form
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • [Ref.29275987] Gram-negative bacteria : Escherichia coli(MIC=4.2 μM)
    • Hemolytic Activity

      • [Ref.29275987] MHC2=587 μM against human red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation (Ala17)
    • Nonterminal Modifications and Unusual Amino Acids

    • The 'A' at position 10 and 14 are 2-(4'-pentenyl)alanine residues and there is a hydrocarbon staple crosslinking them.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Substitutions with polar, known ‘helix-breaker’ Gly residues led to losses in helical character until finally the peptide containing 3 Gly and 1 Asn (S- 6K-F17-3GN) shows a severe loss in helical structure.
    • Helical Wheel Diagram

    • DRAMP21231 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP21231.
    • Formula

    • C87H137N25O19
    • Absent Amino Acids

    • CDEHILMPQRSTVY
    • Common Amino Acids

    • K
    • Mass

    • 1837.2
    • PI

    • 10.7
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 7
    • Net Charge

    • +6
    • Boman Index

    • -2159
    • Hydrophobicity

    • -0.953
    • Aliphatic Index

    • 23.53
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 343.75
    • Polar Residues

    • 4

DRAMP21231

    • Function

    • Antibacterial activity against Gram-negative bacteria
  • ·Literature 1
    • Title

    • Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides.
    • Reference

    • Bioorg Med Chem. 2018 Mar 15;26(6):1189-1196. doi: 10.1016/j.bmc.2017.10.020.
    • Author

    • Stone TA, Cole GB, Nguyen HQ, Sharpe S, Deber CM