General Information

    • DRAMP ID

    • DRAMP21304

    • Peptide Name

    • A21-PMAP-23 (Derived from PMAP-23)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RIIDLLWRVRRPQKPKFVTVAVR

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.10527878] Gram-positive bacteria : Bacillus subtilis (KCTC 1918)(MIC=3.125 μM), Streptococcus pyogenes (KCTC 3096)(MIC=3.125 μM), Staphylococcus aureus (KCTC 1621)(MIC=6.25 μM);
      • Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=6.25 μM), Salmonella typhimurium (KCTC 1926)(MIC=3.125 μM), Pseudomonas aeruginosa (KCTC 1637)(MIC=3.125 μM)

    • Hemolytic Activity

      • [Ref.10527878] 0% hemolysis at 100 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix, beta turn

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21304 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21304.

Physicochemical Information

    • Formula

    • C132H224N42O28

    • Absent Amino Acids

    • CEGHMNSY

    • Common Amino Acids

    • R

    • Mass

    • 2847.5

    • PI

    • 12.18

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +6

    • Boman Index

    • -5957

    • Hydrophobicity

    • -0.178

    • Aliphatic Index

    • 122.61

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 250

    • Polar Residues

    • 1

DRAMP21304

DRAMP21304 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Effects of tryptophan residues of porcine myeloid antibacterial peptide PMAP-23 on antibiotic activity.

    • Reference

    • Biochem Biophys Res Commun. 1999 Oct 14;264(1):281-6.

    • Author

    • Kang JH, Shin SY, Jang SY, Kim KL, Hahm KS.