General Information

    • DRAMP ID

    • DRAMP21305

    • Peptide Name

    • R8 (De novo synthesis)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RRRRRRRR

    • Sequence Length

    • 8

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=44 μM);
      • Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=44 μM)

    • Hemolytic Activity

      • [Ref.23085001] HC50>128 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21305 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21305.

Physicochemical Information

    • Formula

    • C48H98N32O9

    • Absent Amino Acids

    • ACDEFGHIKLMNPQSTV

    • Common Amino Acids

    • R

    • Mass

    • 1267.52

    • PI

    • 12.85

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 0

    • Net Charge

    • +8

    • Boman Index

    • -11936

    • Hydrophobicity

    • -4.5

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21305

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure.

    • Reference

    • Biochim Biophys Acta. 2013 Feb;1828(2):223-32. doi: 10.1016/j.bbamem.2012.10.010.

    • Author

    • Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM