• DRAMP ID

    • DRAMP21306
    • Peptide Name

    • TL-1 (Derived from Temporin-1Tl (TL))
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FVQWWSKWLGRIL
    • Sequence Length

    • 13
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic form
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.26311041] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 μM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 μM), Staphylococcus aureus (KCTC 1621)(MIC=2 μM);
      • Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=4 μM), Pseudomonas aeruginosa (KCTC 1637)(MIC=32 μM), Salmonella typhimurium (KCTC 1926)(MIC=4 μM)
    • Hemolytic Activity

      • [Ref.26311041] HC50=21.4 μM against human red blood cells
    • Cytotoxicity

      • [Ref.26311041] The cell viability of RAW264.7 macrophages cells induced by TL-1 is 112.2%, 109.3% and 109.3% at peptide concentrations of 2.5, 5 and 10 μM.
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP21306 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP21306.
    • Formula

    • C87H123N21O16
    • Absent Amino Acids

    • ACDEHMNPTY
    • Common Amino Acids

    • W
    • Mass

    • 1719.06
    • PI

    • 11
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +2
    • Boman Index

    • 30
    • Hydrophobicity

    • 0.254
    • Aliphatic Index

    • 112.31
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 16500
    • Absorbance 280nm

    • 1375
    • Polar Residues

    • 2

DRAMP21306

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
  • ·Literature 1
    • Title

    • Enhancement of the anti-inflammatory activity of temporin-1Tl-derived antimicrobial peptides by tryptophan, arginine and lysine substitutions.
    • Reference

    • J Pept Sci. 2015 Oct;21(10):779-85. doi: 10.1002/psc.2807.
    • Author

    • Rajasekaran G, Kamalakannan R, Shin SY