General Information

    • DRAMP ID

    • DRAMP21446

    • Peptide Name

    • peptide 23 (Derived from B1)

    • Source

    • synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KKKXAFA

    • Sequence Length

    • 7

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.30842436] Gram-positive bacteria: MRSP C22963(MIC=2-4 µg/ml), MSSA ATCC 29213(MIC=32-64 µg/ml);
      • Gram-negative bacteria: Pseudomonas aeruginosa(MIC= 8 µg/ml)

    • Hemolytic Activity

      • [Ref.30842436] EC10=14μM, EC50=104μM, 59% hemolysis at 150 µM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Nle4 is norleucine. Residue 5 and residue 7 are 2-naphthylmethylglycine

    • Stereochemistry

    • L

    • Structure

    • Random coils most likely

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21446 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21446.

Physicochemical Information

    • Formula

    • C33H55N9O6

    • Absent Amino Acids

    • CDEGHILMNPQRSTVWY

    • Common Amino Acids

    • K

    • Mass

    • 803.2

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +3

    • Boman Index

    • -1005

    • Hydrophobicity

    • -0.757

    • Aliphatic Index

    • 28.57

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21446

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections

    • Reference

    • Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi: 10.1038/s41598-019-39042-3

    • Author

    • Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen