General Information
-
DRAMP ID
- DRAMP21454
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Peptide Name
- PLP1 (Insects, animals)
-
Source
- Odontomachus monticola (Trap-jaw ant)
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Family
- Belongs to the formicidae venom precursor-01 superfamily.
-
Gene
- Not found
-
Sequence
- GILDWGKKVMDWIKDKM
-
Sequence Length
- 17
-
UniProt Entry
- A0A348G6I7
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC<3.1μM);
- Gram-negative bacteria:Escherichia coli (MIC<3.1μM);
- Fungi:Saccharomyces cerevisiae (MIC<50μM)
-
Hemolytic Activity
-
- [Ref.30658410] 0% hemolysis at 50 μM against rat blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- α-helix predicted by Proteus
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21454.
Physicochemical Information
-
Formula
- C95H151N23O24S2
Absent Amino Acids
- ACEFHNPQRSTY
Common Amino Acids
- K
Mass
- 2063.5
PI
- 8.43
Basic Residues
- 4
Acidic Residues
- 3
Hydrophobic Residues
- 6
Net Charge
- +1
-
Boman Index
- -1832
Hydrophobicity
- -0.465
Aliphatic Index
- 85.88
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 687.5
Polar Residues
- 2
DRAMP21454
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria. Antifungal activity against Saccharomyces cerevisiae.
Literature Information
- ·Literature 1
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Title
- Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components
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Pubmed ID
- 30658410
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Reference
- Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi: 10.3390/toxins11010050
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Author
- Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki