General Information
-
DRAMP ID
- DRAMP21455
-
Peptide Name
- PLP2 (Insects, animals)
-
Source
- Odontomachus monticola (Trap-jaw ant)
-
Family
- Belongs to the formicidae venom precursor-01 superfamily.
-
Gene
- Not found
-
Sequence
- GWGSIFKTVGKMIAKAAVKAAPEAISAMASQNE
-
Sequence Length
- 33
-
UniProt Entry
- A0A348G5V8
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC<6.2μM);
- Gram-negative bacteria:Escherichia coli (MIC<6.2μM);
- Fungi:Saccharomyces cerevisiae (MIC<50μM)
-
Hemolytic Activity
-
- [Ref.30658410] 10.4% hemolysis at 50 μM against rat blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- α-helix predicted by Proteus
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21455.
Physicochemical Information
-
Formula
- C149H244N40O44S2
Absent Amino Acids
- CDHLRY
Common Amino Acids
- A
Mass
- 3363.94
PI
- 9.53
Basic Residues
- 4
Acidic Residues
- 2
Hydrophobic Residues
- 15
Net Charge
- +2
-
Boman Index
- -1062
Hydrophobicity
- 0.197
Aliphatic Index
- 77.27
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 171.88
Polar Residues
- 8
DRAMP21455
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria. Antifungal activity against Saccharomyces cerevisiae.
Literature Information
- ·Literature 1
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Title
- Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components
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Pubmed ID
- 30658410
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Reference
- Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi: 10.3390/toxins11010050
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Author
- Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki