General Information

    • DRAMP ID

    • DRAMP21457

    • Peptide Name

    • PLP4 (Insects, animals)

    • Source

    • Odontomachus monticola (Trap-jaw ant)

    • Family

    • Belongs to the formicidae venom precursor-01 superfamily.

    • Gene

    • Not found

    • Sequence

    • GVKELFGKAWGLVKKHLPKACGLLGYVKQ

    • Sequence Length

    • 29

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC<3.1μM);
      • Gram-negative bacteria:Escherichia coli (MIC<3.1μM);
      • Fungi:Saccharomyces cerevisiae (MIC<3.1μM)

    • Hemolytic Activity

      • [Ref.30658410] 10.5% hemolysis at 50 μM against rat blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Cys21 is S-(carbamoylmethyl)-L-cysteine and there is a interchain disulfide bond between two PLP4 peptide molecules.

    • Stereochemistry

    • L

    • Structure

    • α-helix predicted by Proteus

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21457 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21457.

Physicochemical Information

    • Formula

    • C150H243N39O34S

    • Absent Amino Acids

    • DIMNRST

    • Common Amino Acids

    • K

    • Mass

    • 3168.88

    • PI

    • 9.9

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +6

    • Boman Index

    • 118

    • Hydrophobicity

    • 0.038

    • Aliphatic Index

    • 104.14

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 249.64

    • Polar Residues

    • 7

DRAMP21457

DRAMP21457 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria. Antifungal activity against Saccharomyces cerevisiae.

Literature Information

  • ·Literature 1

    • Title

    • Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components

    • Reference

    • Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi: 10.3390/toxins11010050

    • Author

    • Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki