General Information

    • DRAMP ID

    • DRAMP21458

    • Peptide Name

    • PLP5 (Insects, animals)

    • Source

    • Odontomachus monticola (Trap-jaw ant)

    • Family

    • Belongs to the formicidae venom precursor-01 superfamily.

    • Gene

    • Not found

    • Sequence

    • IWGALLGTLIPAITSAIQ

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC Negative);
      • Gram-negative bacteria:Escherichia coli (MIC<50μM);
      • Fungi:Saccharomyces cerevisiae (MIC Negative)

    • Hemolytic Activity

      • [Ref.30658410] 6.9% hemolysis at 10μM and 94.8% at 50 μM against rat blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • α-helix predicted by Proteus

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21458 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21458.

Physicochemical Information

    • Formula

    • C87H144N20O23

    • Absent Amino Acids

    • CDEFHKMNRVY

    • Common Amino Acids

    • I

    • Mass

    • 1838.22

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • 0

    • Boman Index

    • 3000

    • Hydrophobicity

    • 1.433

    • Aliphatic Index

    • 168.33

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 323.53

    • Polar Residues

    • 5

DRAMP21458

DRAMP21458 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-nagetive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components

    • Reference

    • Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi: 10.3390/toxins11010050

    • Author

    • Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki