General Information

    • DRAMP ID

    • DRAMP21596

    • Peptide Name

    • Ac-UM-14W

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KAAKAAKKAAKAAWK

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Non-antimicrobial

    • Target Organism

      • [Ref.26235946] Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC > 200 μM), Staphylococcus aureus ATCC 6538p (MIC > 200 μM), Staphylococcus epidermis ATCC 12228 (MIC > 200 μM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC > 200 μM), Shigella dysentariae ATCC 9752 (MIC > 200 μM), Salmonella typhimurium ATCC 14028 (MIC > 200 μM), Klebsiella pneumonia ATCC 10031 (MIC > 200 μM), Pseudomonas aeruginosa ATCC 27853 (MIC > 200 μM).

    • Hemolytic Activity

      • [Ref.26235946] <1% hemolysis against human red blood cells at 12.5 μM and <1% hemolysis at 25 μM.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acetylation

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Less α-helix content found in a 25mM potassium phosphate buffer solution at 20℃

    • Structure Description

    • Helix formation of unmodified analog Ac-UM-14W would be unfavorable due to the potential electrostatic repulsion among cationic side-chains of lysine residues in its helical conformation.

    • Helical Wheel Diagram

    • DRAMP21596 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21596.

Physicochemical Information

    • Formula

    • C₇₁H₁₂₄N₂₂O₁₆

    • Absent Amino Acids

    • CDEFGHILMNPQRSTVY

    • Common Amino Acids

    • A

    • Mass

    • 1541.9

    • PI

    • 10.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +6

    • Boman Index

    • -1649

    • Hydrophobicity

    • -0.66

    • Aliphatic Index

    • 53.33

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:3 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 0

DRAMP21596

Comments Information

    • Function

    • Non-antibacterial activity against Gram-positive or Gram-negative bacteria. Antibacterial activity is not noteable under 200 μM.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity of doubly-stapled alanine/lysine-based peptides

    • Reference

    • Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. doi: 10.1016/j.bmcl.2015.06.053. Epub 2015 Jun 19.

    • Author

    • Thuy T T Dinh, Do-Hee Kim, Huy X Luong, Bong-Jin Lee, Young-Woo Kim