• DRAMP ID

    • DRAMP21649
    • Peptide Name

    • SLAY-P3
    • Source

    • Synthetic construct after SLAY screening and prediction
    • Family

    • N/A
    • Gene

    • N/A
    • Sequence

    • TCRTNRPCFYDLDLNVCRCS
    • Sequence Length

    • 20
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic form
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • [Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC > 128 μM), Acinetobacter baumannii 5075 (MBC = 128 μM), Pseudomonas aeruginosa 14 (MBC > 128 μM), E. coli conferring New Delhi metallo-beta-lactamase (MBC > 128 μM).
    • Hemolytic Activity

      • [Ref.29307492] No hemolytic activity information found.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Unknown
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Unknown
    • Structure Description

    • Not mentioned
    • Helical Wheel Diagram

    • DRAMP21649 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP21649.
    • Formula

    • C97H155N31O31S4
    • Absent Amino Acids

    • AEGHIKMQW
    • Common Amino Acids

    • C
    • Mass

    • 2379.73
    • PI

    • 7.58
    • Basic Residues

    • 3
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +1
    • Boman Index

    • -6218
    • Hydrophobicity

    • -0.4
    • Aliphatic Index

    • 53.5
    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1740
    • Absorbance 280nm

    • 91.58
    • Polar Residues

    • 10

DRAMP21649

DRAMP21649 chydropathy plot
    • Function

    • Slight antibacterial activity against Gram-negative bacteria.
  • ·Literature 1
    • Title

    • Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
    • Reference

    • Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.
    • Author

    • Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies