General Information
-
DRAMP ID
- DRAMP21650
-
Peptide Name
- SLAY-P5
-
Source
- Synthetic construct after SLAY screening and prediction
-
Family
- N/A
-
Gene
- N/A
-
Sequence
- YYNPLPHDCGRDNNTDICSR
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
-
Target Organism
-
- [Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC > 128 μM), Acinetobacter baumannii 5075 (MBC > 128 μM), Pseudomonas aeruginosa 14 (MBC = 128 μM), E. coli conferring New Delhi metallo-beta-lactamase (MBC > 128 μM).
-
Hemolytic Activity
-
- [Ref.29307492] No hemolytic activity information found.
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Unknown
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Unknown
-
Structure Description
- Not mentioned
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21650.
Physicochemical Information
-
Formula
- C97H145N31O34S2
Absent Amino Acids
- AEFKMQVW
Common Amino Acids
- DN
Mass
- 2353.53
PI
- 5.3
Basic Residues
- 3
Acidic Residues
- 3
Hydrophobic Residues
- 2
Net Charge
- 0
-
Boman Index
- -7349
Hydrophobicity
- -1.38
Aliphatic Index
- 39
Half Life
-
- Mammalian:2.8 hour
- Yeast:10 min
- E.coli:2 min
Extinction Coefficient Cystines
- 3105
Absorbance 280nm
- 163.42
Polar Residues
- 10
DRAMP21650
Comments Information
Function
- Slight antibacterial activity against Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
-
Pubmed ID
- 29307492
-
Reference
- Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.
-
Author
- Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies