General Information

    • DRAMP ID

    • DRAMP29088

    • Peptide Name

    • MK58911 (a peptide analog from the mastoparan class of wasps)

    • Source

    • Galleria mellonella

    • Family

    • Not found

    • Gene

    • N/A

    • Sequence

    • INWLKIAKKVKGML

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal, Antitumor

    • Target Organism

      • [Ref.31867293] Fungi: C. neoformans (MIC = 31.2 μg/mL), C. gattii (MIC = 15.6 μg/mL), P. brasiliensis (MIC = 7.8 μg/mL), P. lutzii (MIC = 15.6 μg/mL)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.31867293]MK58911 was not toxic in lung fibroblasts (MRC5) and glioblastoma cells (U87) at tested concentrations, and a high IC50 of >500 μg/mL was observed in both mammalian cells.

    • Binding Target

    • Fungal cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29088 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29088.

Physicochemical Information

    • Formula

    • C78H136N20O16S

    • Absent Amino Acids

    • CDEFHPQRSTY

    • Common Amino Acids

    • K

    • Mass

    • 1642.12

    • PI

    • 10.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • 231

    • Hydrophobicity

    • 0.293

    • Aliphatic Index

    • 139.29

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 2

DRAMP29088

Comments Information

    • Comment

    • MK58911 is not toxic in two mammalian cells (lung fibroblasts and glioblastoma cells) and in the G. mellonella model and demonstrates both in vitro and in vivo antifungal efficacy. Moreover, the peptide acted on the membrane of fungal cells and induced necrosis.

Literature Information

  • ·Literature 1

    • Title

    • Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide

    • Reference

    • Front Cell Infect Microbiol. 2019 Dec 6;9:419. doi: 10.3389/fcimb.2019.00419. eCollection 2019.

    • Author

    • Singulani JL, Galeane MC, Ramos MD, Gomes PC, Dos Santos CT, de Souza BM, Palma MS, Fusco Almeida AM, Mendes Giannini MJS.