• DRAMP ID

    • DRAMP29139
    • Peptide Name

    • Pxt‐1
    • Source

    • Xenopus tropicalis
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • IRPIPFIPRGGKT
    • Sequence Length

    • 13
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.25312021]Gram-negative bacteria:Escherichia coli DH5α(Not active up to 150 µg/ml);
      • Gram-positive bacteria:Staphylococcus aureus JCM 2151(Not active up to 150 µg/ml).
    • Hemolytic Activity

      • [Ref.25312021]0.1% Hemolysis against Rat erythrocytes at 20 µM.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Alpha helix,random coil
    • Structure Description

    • 10.9%,12.2%,12.7% α-helix were mearsured by CD spectra at 10 °C, 25 °C and 37 °C in 10 mm Tris-HCl (pH 7.2).
    • Helical Wheel Diagram

    • DRAMP29139 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29139.
    • Formula

    • C68H114N20O15
    • Absent Amino Acids

    • ACDEHLMNQSVWY
    • Common Amino Acids

    • IP
    • Mass

    • 1451.78
    • PI

    • 12.01
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +3
    • Boman Index

    • -1834
    • Hydrophobicity

    • -0.223
    • Aliphatic Index

    • 90
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP29139

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.
  • ·Literature 1
    • Title

    • Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis.
    • Reference

    • FEBS J. 2015 Jan;282(1):102-13.
    • Author

    • Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M.