General Information

    • DRAMP ID

    • DRAMP31856

    • Peptide Name

    • Ps-2Pa

    • Source

    • skin secretions of the frog Pseudhymenochirus merlini (Pipidae)

    • Family

    • Gene

    • Not found

    • Sequence

    • GIFPIFAKLLGKVIKVASSLISKGRTE

    • Sequence Length

    • 27

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: HT-29 (LC50=11.5±2.6 μM); A549 (LC50=6.0±0.6 μM); MDA-MB-231 (LC50=6.2±0.6 μM)

    • Hemolytic Activity

      • Human erythrocytes: LC50=6.2±1.0 μM

    • Cytotoxicity

      • HUVEC: LC50=68±2 μM

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31856 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP31856.

Physicochemical Information

    • Formula

    • C135H230N34O34

    • Absent Amino Acids

    • CDHMNQWY

    • Common Amino Acids

    • IK

    • Mass

    • 333746

    • PI

    • 11.25

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +4

    • Boman Index

    • -178

    • Hydrophobicity

    • 0.648

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP31856

DRAMP31856 chydropathy plot

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa

    • Reference

    • Regul Pept. 2014 Nov;194-195:69-76.

    • Author

    • Mechkarska M, Attoub S, Sulaiman S, Pantic J, Lukic ML, Conlon JM.