DRAMP_ID Sequence Sequence_Length Name Swiss_Prot_Entry Family Gene Source Activity Protein_existence Structure Structure_Description PDB_ID Comments Target_Organism Hemolytic_activity Linear/Cyclic/Branched N-terminal_Modification C-terminal_Modification Other_Modifications Stereochemistry Cytotoxicity Binding_Traget Pubmed_ID Reference Author Title DRAMP00089 TTKNYGNGVCNSVNWCQCGNVWASCNLATGCAAWLCKLA 39 Bacteriocin E50-52 (Preclinical) P85148 Belongs to the class IIa bacteriocin Not found Enterococcus faecium (Streptococcus faecium) (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Bacteriocin active against the Gram-negative bacteria and the Gram-positive bacteria. When added to the drinking water of chickens, causes a decrease in the levels of Campylobacter jejuni and S. enteritidis in the ceca, and in the levels of S.enteritidis in the liver and spleen." "Gram-negative bacteria: Campylobacter jejuni (MIC=0.025-6.4 ?g/ml), Yersinia enterocolitica, Yersinia pseudotuberculosis, Escherichia coli O157:H7 (MIC<1.6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=0.2-0.8 ?g/ml), Staphylococcus epidermidis (MIC=0.2-0.8 ?g/ml), Listeria monocytogenes (MIC=2-8 ?g/ml), Listeria grayi, Listeria innocua, Listeria ivanovii, Listeria denitrificans (MIC=32 ?g/ml), Morganella morganii, Salmonella spp., Shigella dysenteriae." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 18293921 J Agric Food Chem. 2008 Mar 26;56(6):1942-1948. "Svetoch EA, Eruslanov BV, Perelygin VV, Mitsevich EV, Mitsevich IP, Borzenkov VN, Levchuk VP, Svetoch OE, Kovalev YN, Stepanshin YG, Siragusa GR, Seal BS, Stern NJ." Diverse antimicrobial killing by Enterococcus faecium E 50-52 bacteriocin. DRAMP00107 TNYGNGVGVPDAIMAGIIKLIFIFNIRQGYNFGKKAT 37 Bacteriocin L-1077 No entry found Belongs to the class IIa bacteriocin Not found Lactobacillus salivarius L-1077 (NRRL B-50053) (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Salmonella Enteritidis 1 (MIC=0.19 ug/ml), S. Enteritidis 4 (MIC=0.38 ug/ml), S. Enteritidis 204 (MIC=0.38 ug/ml), S. Enteritidis 237 (MIC=0.19 ug/ml), Salmonella Choleraesuis 434/4 (MIC=0.38 ug/ml), S. Choleraesuis 370 (MIC=0.19 ug/ml), Salmonella Typhimurium 483/6 (MIC=0.19 ug/ml), S. Typhimurium 44/8 (MIC=0.19 ug/ml), Salmonella Gallinarum-Pullorum (MIC=0.19 ug/ml), Escherichia coli HB 101 (MIC=0.19 ug/ml), E. coli-600 (MIC=0.19 ug/ml), E. coli O157:H7 Y-63 (MIC=0.19 ug/ml), E. coli O157:H7 G-35 (MIC=0.19 ug/ml), E. coli O157:H7 OD 30 (MIC=0.19 ug/ml), E. coli O157:H7 T lab 39 (MIC=0.19 ug/ml), Yersinia enterocolitica 03 (MIC=0.76 ug/ml), Y. enterocolitica 09 (MIC=0.76 ug/ml), Y. enterocolitica 11 (MIC=0.76 ug/ml), Citrobacter freundii (MIC=0.76 ug/ml), Klebsiella pneumoniae (MIC=0.76 ug/ml), Shigella dysenteriae (MIC=0.76 ug/ml), Yersinia pseudotuberculosis 4 (MIC=0.76 ug/ml), Y. pseudotuberculosis 99/14 (MIC=0.76 ?g/ml), Pseudomonas aeruginosa 508 (MIC=0.38 ug/ml), Proteus mirabilis (MIC=0.38 ug/ml), Morganella morganii (MIC=0.38 ?g/ml), Proteus vulgaris 7A (MIC=1.5 ug/ml),Campylobacter jejuni L-4 (MIC=0.09 ug/ml);##Gram-positive bacteria: Clostridium perfringens? 13124 (MIC=0.7 ug/ml), Listeria monocytogenes A 9-72 (MIC=0.19 ug/ml), Staphylococcus aureus (MIC=0.76 ug/ml), Staphylococcus epidermidis (MIC=0.76 ug/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 21378051 Appl Environ Microbiol. 2011 Apr;77(8):2749-2754. "Svetoch EA, Eruslanov BV, Levchuk VP, Perelygin VV, Mitsevich EV, Mitsevich IP, Stepanshin J, Dyatlov I, Seal BS, Stern NJ." "Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum." DRAMP00136 NRWYCNSAAGGVGGAAVCGLAGYVGEAKENIAGEVRKGWGMAGGFTHNKACKSFPGSGWASG 62 Enterocin E-760 (Bacteriocin) P85147 Belongs to the class IIb bacteriocin Not found Enterococcus sp. (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: The enterocin demonstrated thermostability by retaining activity after 5 min at 100 degrees C and was stable at pH values between 5.0 and 8.7. However, activity was lost below pH 3.0 and above pH 9.5. No hemolytic activity." "[Ref.18086839]Gram-positive bacteria: Listeria monocytogenes 9-72 (MIC=0.1 g/ml), Staphylococcus epidermidis (MIC=1.6 g/ml), S. aureus (MIC=1.6 g/ml);##Gram-negative bacteria: S. enterica serovar Enteritidis 1 (MIC=0.2 g/ml), S. enterica serovar Enteritidis 4 (MIC=0.4 g/ml), S. enterica serovar Enteritidis 204 (MIC=0.2 g/ml), S. enterica serovar Enteritidis 237 (MIC=0.2 g/ml), S. enterica serovar Choleraesuis 434/4 (MIC=0.4 g/ml), S. enterica serovar Choleraesuis 370 (MIC=0.4 g/ml), S. enterica serovar Typhimurium 383/60 (MIC=0.4 g/ml), S. enterica serovar Typhimurium 320 (MIC=0.2 g/ml), S. enterica serovar Gallinarum biovar Pullorum (MIC=0.4 g/ml), Escherichia coli HB101 (MIC=0.1 g/ml), E. coli C600 (MIC=0.1 g/ml), E. coli O157:H7 Y-63 (MIC=1.6 g/ml), E. coli O157:H7 G-3 (MIC=1.6 g/ml), E. coli O157:H7 OD-3 (MIC=1.6 g/ml), E. coli O157:H7 T-39 (MIC=1.6 g/ml), Yersinia enterocolitica 03 (MIC=0.1 g/ml), Y. enterocolitica 09 (MIC=0.1 g/ml), Y. enterocolitica 04 (MIC=0.1 g/ml), Y. pseudotuberculosis ser 4 (MIC=3.2 g/ml), Y. pseudotuberculosis 14 (MIC=3.2 g/ml), Citrobacter freundii (MIC=1.6 g/ml), Klebsiella pneumoniae (MIC=3.2 g/ml), Shigella dysenteriae (MIC=0.1 g/ml), Campylobacter jejuni L4 (MIC=0.1 g/ml), Campylobacter P 1-R (MIC=0.2 g/ml), Campylobacter P-45 (MIC=0.4 g/ml), Campylobacter lari R (MIC=0.2 g/ml), Campylobacter LB 6-R (MIC=0.1 g/ml), Campylobacter C/D (MIC=0.2 g/ml),." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 18086839 Antimicrob Agents Chemother. 2008 Mar;52(3):1094-1100. "Line JE, Svetoch EA, Eruslanov BV, Perelygin VV, Mitsevich EV, Mitsevich IP, Levchuk VP, Svetoch OE, Seal BS, Siragusa GR, Stern NJ." Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and Gram-negative bacteria. DRAMP00171 LIDHLGAPRWAVDTILGAIAVGNLASWVLALVPGPGWAVKAGLATAAAIVKHQGKAAAAAW 61 Lactocyclicin Q (Bacteriocin) B9ZZY0 Belongs to the class IIc bacteriocin lycQ Lactococcus sp. strain QU 12 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Lactococcus sp.strain QU 12 (MIC=34.3 ?M), Lactococcus lactis subsp.lactis JCM 7638 (MIC=0.141 ?M), L. lactis subsp.lactis ATCC 19435 (MIC=0.141 ?M), L. lactis subsp.lactis IL1403 (MIC=0.141 ?M), L. lactis QU 1 (MIC=0.141 ?M), L. lactis subsp.cremoris ATCC 19275 (MIC=0.283 ?M), Lactococcus raffinolactis JCM 5706 (MIC=0.71 ?M), Lactobacillus sakei subsp.sakei JCM 1157 (MIC=0.015 ?M), Lactobacillus casei subsp.casei JCM 1134 (MIC=2.27 ?M), Leuconostoc brevis JCM 1059 (MIC=1.14 ?M), L. acidophilus JCM 1132 (MIC=2.86 ?M), L. coryniformis subsp.coryniformis JCM 1164 (MIC=2.86 ?M), L. kimchii JCM 10707 (MIC=0.71 ?M), L. mesenteroides subsp.mesenteroides JCM 6124 (MIC=1.03 ?M), Weissella cibaria JCM 12495 (MIC=0.71 ?M), Pediococcus pentosaceus JCM 5885 (MIC=0.55 ?M), P. pentosaceus JCM 5890 (MIC=2.86 ?M), P. acidilactici JCM 8797 (MIC=2.86 ?M), P. dextrinicus JCM 5887 (MIC=0.141 ?M), Enterococcus faecium JCM5804 (MIC=0.71 ?M), E. hirae ATCC 10541 (MIC=0.71 ?M), E. durans NBRC 100479 (MIC=0.71 ?M), E. faecalis JCM 5803 (MIC=0.26 ?M), Streptococcus salivarius JCM 5707 (MIC=22.9 ?M), S. bovis JCM 5802 (MIC=22.9 ?M), Bacillus coagulans JCM 2257 (MIC=0.015 ?M), B. circulans JCM 2504 (MIC=0.031 ?M), B. subtilis JCM 1465 (MIC=0.064 ?M), B. cereus JCM 2152 (MIC=11.4 ?M), Micrococcus luteus IFO 12708 (MIC=5.7 ?M), Listeria innocua ATCC 33090 (MIC=1.03 ?M), L. monocytogenes ATCC BAA-679 (MIC=1.03 ?M), Staphylococcus aureus subsp.aureus ATCC 12600 (MIC=91.6 ?M); Gram-negative bacteria: Escherichia coli JM109 (MIC=34.3 ?M), E. coli NBRC 3301 (MIC=17.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) The whole peptide has a cyclic structure in which N and C termini are bound to each other. L No cytotoxicity information found Not found 19139222##21948835 Appl Environ Microbiol. 2009 Mar;75(6):1552-1558.##Appl Environ Microbiol. 2011 Nov;77(22):8164-8170. "Sawa N, Zendo T, Kiyofuji J, Fujita K, Himeno K, Nakayama J, Sonomoto K.##Masuda Y, Ono H, Kitagawa H, Ito H, Mu F, Sawa N, Zendo T, Sonomoto K." "Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus sp. strain QU 12.##Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401." DRAMP00191 GGAGHVPEYFVGIGTPISFYG 21 Microcin J25 (MccJ25; Bacteriocin) Q9X2V7 Belongs to the class I microcin mcjA Escherichia coli AY25 (Gram-negative bacteria) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Beta strand "MccJ25 does not have a head-to-tail cyclic structure but rather a side chain to backbone cyclization between Glu8 and the N-terminus. This creates an embedded ring that is threaded by the C-terminal tail of the molecule, forming a noose-like feature. The three-dimensional structure deduced from NMR data suggests that slippage of the noose is prevented by two aromatic residues flanking the embedded ring." "1Q71, 1PP5 resolved by NMR." "Function: Microcin J25 is a 21 amino acid bacterial peptide that has potent antibacterial activity against Gram-negative bacteria, resulting from its interaction with RNA polymerase. Induction: At the onset of stationary growth phase. PTM: Isoglutamyl glycine isopeptide between G1 and E8." "Gram-negative bacteria: Escherichia coli BM21 (MIC=0.08 ?g/ml), E. coli AB1133 (MIC=0.02 ?g/ml), E. coli RYC816 (MIC=0.04 ?g/ml), E. coli AY29 (MIC=0.04 ?g/ml), Salmonella species, Shigella flexneri." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization of a N-terminal between Gly and Glu Free None L No cytotoxicity information found Not found 1429464##10092860##14531690##14531661 J Bacteriol. 1992 Nov;174(22):7428-7435.##Eur J Biochem. 1999 Feb;259(3):747-755.##J Am Chem Soc. 2003 Oct 15;125(41):12464-74.##J Am Chem Soc. 2003 Oct 15;125(41):12382-3. "Salom?n RA, Far?as RN.##Blond A, P?duzzi J, Goulard C, Chiuchiolo MJ, Barth?l?my M, Prigent Y, Salom?n RA, Far?as RN, Moreno F, Rebuffat S.##Rosengren KJ, Clark RJ, Daly NL, G?ransson U, Jones A, Craik DJ.##Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH." "Microcin 25, a novel antimicrobial peptide produced by Escherichia coli.##The cyclic structure of microcin J25, a 21-residue peptide antibiotic from Escherichia coli.##Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone.##Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot." DRAMP00222 GETDPNTQLLNDLGNNMAWGAALGAPGGLGSAALGAAGGALQTVGQGLIDHGPVNVFIPVLIGPSWNGSGSGYNSATSSSGSGS 84 Microcin E492 (MccE492; Bacteriocin) Q9Z4N4 Not found mceA Klebsiella pneumoniae RYC492 (Gram-negative bacteria) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Channel-forming bacteriocin. Forms cation-selective channels. Active on enterobacteria, with highest activity against Escherichia coli. The unmodified protein is active against Escherichia coli and S. enteritidis. When the siderophore ester is present at Ser-99, antibacterial activity against these species is increased and activity is also detected against E. cloacae and K. pneumoniae. PTM: The C-terminal Ser is modified by attachment to a siderophore similar to enterobactin, which can bind one atom of iron. The modification consists of an ester linkage of the serine carboxyl to O6 of a glucose which is linked by a C-glycosidic bond to the 5'-benzoyl of a linear triester of N-(2,3-dihydroxybenzoyl)serine. Presence of the siderophore ester increases the antibacterial activity of the protein." "Gram-negative bacteria: Escherichia coli F (MIC=0.14 ?M), Escherichia coli 363 (MIC=0.02 ?M), Escherichia coli ML35p (MIC=0.14 ?M), Escherichia coli GM1 (MIC=0.04 ?M), Escherichia coli GM1 KP1060(MIC=0.65 ?M), Escherichia coli W3110 (MIC=0.02 ?M), Escherichia coli W3110-KP1344 Pms7 (MIC=0.08 ?M), Escherichia coli W3110-6 (MIC=0.32 ?M), Escherichia coli C600 (MIC=0.08 ?M), Escherichia coli C600 pHX405 (MIC=0.16 ?M), Salmonella enteritidis (MIC=0.6 ?M), Salmonella typhimurium (MIC=1.2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Attachment to a siderophore ester "[Ref.15102848] The post-translational modification consists of a trimer of N-(2,3-dihydroxybnenzoyl)-L-serine linked via a C-glycosidic linkage to a -D-glucose moiety, itself linked to the MccE492m Ser-84-carboxyl through an O-glycosidic bond." L No cytotoxicity information found Not found 12890026##15102848##7682973 Mol Microbiol. 2003 Aug;49(4):1031-1041.##J Biol Chem. 2004 Jul 2;279(27):28233-28242.##FEBS Lett. 1993 Apr 26;321(2-3):145-148. "Destoumieux-Garz?n D, Thomas X, Santamaria M, Goulard C, Barth?l?my M, Boscher B, Bessin Y, Molle G, Pons AM, Letellier L, Peduzzi J, Rebuffat S.##Thomas X, Destoumieux-Garz?n D, Peduzzi J, Afonso C, Blond A, Birlirakis N, Goulard C, Dubost L, Thai R, Tabet JC, Rebuffat S.##Lagos R, Wilkens M, Vergara C, Cecchi X, Monasterio O." "Microcin E492 antibacterial activity: evidence for a TonB-dependent inner membrane permeabilization on Escherichia coli.##Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity.##Microcin E492 forms ion channels in phospholipid bilayer membrane." DRAMP00336 IPCGESCVWIPCITAIAGCSCKNKVCYT 28 ChaC7 (Chassatide C7; uncyclotides; Plant defensin) No entry found "Belongs to the Bracelet subfamily, Rubiaceae family" Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "IC50=1.2 ?M, HD50=11.6 ?M. Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC=6.4 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50 = 11.6 M against on human red blood cells (Type A). Kalata B1 and melittin were used as the positive control. Linear Free Free None L [Ref.22467870] IC50 = 1.2 M targeting on HeLa cells. Kalata B1 was used as the positive control. Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00337 AIPCGESCVWIPCISTVIGCSCSNKVCYR 29 ChaC8 (Chassatide C8; uncyclotides; Plant defensin) No entry found "Belongs to the Bracelet subfamily, Rubiaceae family" Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "IC50=1.0 ?M, HD50=25.5 ?M. Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC=6.6 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50 = 25.5 M against human red blood cells (Type A). Kalata B1 and melittin were used as the positive control. Linear Free Free None L [Ref.22467870] IC50 = 1.0 M targeting on HeLa cells. Kalata B1 was used as the positive control. Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00338 IPCGESCVWIPCISGMFGCSCKDKVCYS 28 ChaC11 (Chassatide C11; uncyclotides; Plant defensin) No entry found "Belongs to the Bracelet subfamily, Rubiaceae family" Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "IC50=1.2 ?M, HD50=13.3 ?M. Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC=8.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50 = 13.3 M against human red blood cells (Type A). Kalata B1 and melittin were used as the positive control. Linear Free Free None L [Ref.22467870] IC50 = 5.0 M targeting on HeLa cells. Kalata B1 was used as the positive control. Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00385 QLPICGETCVLGGCYTPNCRCQYPICVR 28 Panitide L2 (plants) No entry found Not found Not found Panicum laxum "Antimicrobial, Antibacterial, Anti-Gram-" Not found Bridge Not found None PTM: N-terminus is a pyruglutamyl. Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Pyroglutamyl modification Free There are three disulfide bonds in the peptide structure L [Ref.23195955] IC50 = 6.0 M against HeLa cells. Not found 23195955 J Biol Chem. 2013 Feb 1;288(5):3370-3380. "Nguyen GK, Lian Y, Pang EW, Nguyen PQ, Tran TD, Tam JP." Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. DRAMP00431 KTCMTKKEGWGRCLIDTTCAHSCRKYGYMGGKCQGITRRCYCLLNC 46 Defensin-like protein 2 (Cp-thionin II; Cp-thionin-2; Gamma-thionin II; Plant defensin) P84920 Belongs to the DEFL family Not found Vigna unguiculata (Cowpea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli and P. syringae. Does not have antibacterial activity against the phytopathogenic bacteria R. solanacearum, Rhataybacter sp and Erwinia sp. Does not inhibit trypsin, chymotrypsin or alpha-amylases. Tissue specificity: Present in seeds, cotyledons and leaves. Not found in roots or stems. Developmental stage: Present in seeds and seedlings, levels decrease with seedling age. Light increases the rate of degradation. Present until 9 days in seedlings kept in the dark, not found after 6 days in seedings kept in the light. PTM: Contains four disulfide bonds 3-46; 13-33; 19-40; 23-42." "Gram-positive bacterium: Staphylococcus aureus ATTC 25923 (MIC=128 mg/ml);##Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=64 mg/ml), Pseudomonas syringae (MIC=42 mg/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) "There are four disulfide bonds between Cys3 and Cys46, Cys13 and Cys33, Cys19 and Cys40, Cys23 and Cys42" L No cytotoxicity information found Not found 16824043 FEBS J. 2006 Aug;273(15):3489-3497. "Franco OL, Murad AM, Leite JR, Mendes PA, Prates MV, Bloch C Jr." Identification of a cowpea gamma-thionin with bactericidal activity. DRAMP00764 KSLRPRCWIKIKFRCKSLKF 20 Piceain 1 (Plants) No entry found Not found Not found Picea sitchensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Beta strand (CD) Not found None "Function: Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells. PTM: Contains one disulfide bond." "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 ?g/ml), S. aureus ATCC 43300 (MIC=9.38 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=18.75 ?g/ml), Escherichia coli ML-35P (MIC=18.75 ?g/ml), Escherichia coli 08040722 (CI) (MIC=75 ?g/ml), Escherichia coli 08A866 (CI) (MIC=37.5 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 ?g/ml).##Yeast: Candida albicans ATCC 20032 (MIC=9.38 ?g/ml)." "[Ref.21644248] At the concentration of 0.0625 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.7% & 1.5%; At the concentration of 0.125 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 7.2%; At the concentration of 0.25 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.9%&7.8%; At the concentration of 0.5 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.6% & 9.5%; At the concentration of 1 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.8% & 57.1%." Cyclic Free Free There is one intra-molecular disulfide bridge formed by Cys7 and Cys15. L No cytotoxicity information found Not found 21644248 J Pept Sci. 2011 Sep;17(9):627-631. "Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R." Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis. DRAMP00765 RPRCWIKIKFRCKSLKF 17 Piceain 2 (Plants) No entry found Not found Not found Picea sitchensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells. PTM: Contains one disulfide bond." "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 ?g/ml), S. aureus ATCC 43300 (MIC=18.75 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=37.5 ?g/ml), Escherichia coli ML-35P (MIC=37.5 ?g/ml), Escherichia coli 08040722 (CI) (MIC=75 ?g/ml), Escherichia coli 08A866 (CI) (MIC=37.5 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=18.75 ?g/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 ?g/ml).##Yeast: Candida albicans ATCC 20032 (MIC=18.75 ?g/ml)." "[Ref.21644248] At the concentration of 0.0625 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.6% & 2.2%; At the concentration of 0.125 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 4.7%; At the concentration of 0.25 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.2%&5.2%; At the concentration of 0.5 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.3% & 12.4%; At the concentration of 1 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 11.3% & 66.3%." Cyclic Free Free There is one intra-molecular disulfide bridge formed by Cys4 and Cys12. L No cytotoxicity information found Not found 21644248 J Pept Sci. 2011 Sep;17(9):627-631. "Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R." Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis. DRAMP00766 KVFLGLK 7 JCpep7 (Plants) No entry found Not found Not found Jatropha curcas "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: JCpep7 killed microbes principally via breaking of their cell walls and membranes, followed by cell lysis." "Gram-negative bacteria: Salmonella typhimurium ATCC 50013 (MIC=48 ?g/ml), Shigella dysenteriae ATCC 51302 (MIC=48 ?g/ml), Pseudomonas aeruginosa ATCC 27553 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=40 ?g/ml), Bacillus subtilis ATCC 23631 (MIC=24 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC=56 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 21268582 J Agric Food Chem. 2011 Feb 23;59(4):1145-1151. "Xiao J, Zhang H, Niu L, Wang X." Efficient Screening of a Novel Antimicrobial Peptide from Jatropha curcas by Cell Membrane Affinity Chromatography. DRAMP00774 GTRCGETCFVLPCWSAKFGCYCQKGFCYRN 30 Hedyotide B1 (hB1; Plants) No entry found Belongs to the cyclotide family Not found Hedyotis biflora (aerial tissues) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=3.4 ?M);##Gram-positive bacteria: Streptococcus salivarius(MIC=5.9 ?M), Staphylococcus epidermidis (MIC>80 ?M), S. aureus (MIC>80 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free There are three disulfide bonds in the peptide structure L No cytotoxicity information found Not found 21979955 J Biol Chem. 2011 Dec 30;286(52):44833-44844. "Nguyen GK, Zhang S, Wang W, Wong CT, Nguyen NT, Tam JP." Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. DRAMP00795 GIPCGESCVFIPCITAAIGCSCKSKVCYRN 30 Cliotide T1 (cT1; Plant defensin) No entry found Belongs to the cyclotide family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Cliotide T1 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=7.1 ?M) and cytotoxicity against HeLa Cells (IC50=0.6 ?M). [Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. " "[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC=1.1 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC=2.7 ?M), Klebsiella pneumonia ATCC 13883 (MIC=4.7 ?M)." [Ref.21596752] HD50 = 7.1 M against human red blood cells Cyclic Free Free "There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27." L [Ref.21596752] IC50=0.6 ?M against HeLa cells. Not found 21596752 J Biol Chem. 2011 Jul 8;286(27):24275-24287. "Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP." Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. DRAMP00798 GIPCGESCVFIPCITGAIGCSCKSKVCYRN 30 Cliotide T4 (cT4; Plant defensin) No entry found Belongs to the cyclotide family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Cliotide T4 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=8.4 ?M) and cytotoxicity against HeLa Cells (IC50=0.6 ?M). [Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. " "[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC=1.3 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC=1.9 ?M), Klebsiella pneumonia ATCC 13883 (MIC=1.5 ?M)." [Ref.21596752] HD50 = 8.4 M against human red blood cells Cyclic Free Free "There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27." L [Ref.21596752] IC50=0.6 ?M against HeLa cells. Not found 21596752 J Biol Chem. 2011 Jul 8;286(27):24275-24287. "Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP." Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. DRAMP00856 GLPVCGETCVGGTCNTPGCTCSWPVCTRN 29 Kalata-B1 (Plant defensin) P56254 Belongs to the cyclotide family OAK1 Oldenlandia affinis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Beta strand (3 strands; 7 residues) Not found 2KHB resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans. Active against the Gram-positive S. aureus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. Inhibitory effect on the growth and development of larvae from H. punctigera. The unmodified form has hemolytic activity, the oxidized form lacks hemolytic activity. If the protein is linearized, hemolytic activity is lost. MOA: a small number of cyclotides bind to the membrane surface and then insert first into the outer membrane leaflet followed by penetration through the membrane and pore formation. At higher concentrations of cyclotides, destabilization of membranes occurs. Tissue specificity: Leaves and stems. Lower in roots. Pharmaceutical use: The uteroactive properties of Kalata have been discovered by African traditional medicine. It is used as an ingredient of a herbal tea to accelerate childbirth. PTM: Kalata-B1 is a cyclic peptide which contains three disulfide bonds 5-19; 11-21; 14-26." "[Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.26 ?M), Micrococcus luteus (MIC=40.4 ?M);##Gram-negative bacterium: Klebsiella oxytoca (MIC=54.8 ?M);##Fungi: Candida kefyr (MIC=21.4 ?M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=140 nM)." [Ref.12779323] HD50 = 300 M against Human type A red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.7703226] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys26." L [Ref.18008336]CEM-SS cells:IC50=3500 nM. Cell membrance 18008336##10430870##7703226##17534989##23129773 Biopolymers. 2008;90(1):51-60.##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biochemistry. 1995 Apr 4;34(13):4147-4158.##Chembiochem. 2007 Jun 18;8(9):1001-1011.##J Biol Chem. 2012 Dec 21;287(52):43884-98. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, G?ransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ." "Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions." DRAMP00877 GIPCGESCVWIPCISAALGCSCKNKVCYRN 30 Circulin-A (CIRA; Plant defensin) P56871 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Alpha helix (1 helices; 4 residues) "The molecule is stabilised by three disulfide bonds, two of which form an embedded loop completed by the backbone fragments connecting the cysteine residues. A third disulfide bond threads through the centre of this loop to form a ""cystine-knot"" motif. This motif is present in a range of other biologically active proteins, including omega-contoxin GVIA and Cucurbita maxima trypsin inhibitor." 1BH4 resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. PTM: This is a cyclic peptide which contains three disulfide bonds 1-17; 5-19; 10-24." [Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.19 ?M).##Gram-negative bacterium: Proteus vulgaris (MIC=54.6 ?M).##Fungi: Candida kefyr (MIC=18.6 ?M) and Candida tropicalis (MIC=19.4 ?M).##NOTE: Medium with 10 mM phosphate buffer.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM). [Ref.10430870] EC50 = 1020 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.8920961] There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27" L [Ref.18008336]CEM-SS cells:IC50=500 nM. Not found 18008336##10430870##9878410##8920961 Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. ##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J. Mol. Biol. 1999; 285:333-345. ##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##Tam JP, Lu YA, Yang JL, Chiu KW.##Daly NL, Koltay A, Gustafson KR, Boyd MR, Casas-Finet JR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell" "Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides" DRAMP00878 GVIPCGESCVFIPCISTLLGCSCKNKVCYRN 31 Circulin-B (CIRB; Plant defensin) P56879 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Beta strand (5 strands; 10 residues) Cyclotides are mini-proteins derived from plants that have the characteristic features of a head-to-tail cyclised peptide backbone and a knotted arrangement of their three disulfide bonds. 2ERI resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria. PTM: This is a cyclic peptide which contains three disulfide bonds 5-21; 9-23; 14-28." "[Ref.10430870]Gram-positive bacterium: (L-salt): Staphylococcus aureus (MIC=13.5 ?M).##Gram-negative bacteria: (L-salt, H-salt) (MIC ?M): Escherichia coli (0.41, >500), Pseudomonas aeruginosa (25.5, 48), Proteus vulgaris (6.8, >500), Klebsiella oxytoca (8.2, 15.6).##Fungi (H-salt): Candida kefyr (MIC=29 ?M).##NOTE: L-salt = Medium with 10 mM phosphate buffer; H-salt = L-salt supplemented with 100 mM NaCl.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM)." [Ref.10430870] EC50 = 550 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.8920961] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys27." L [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 820 M.##[Ref.18008336]CEM-SS cells:IC50=500 nM. Not found 10430870##18008336##8920961 Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biopolymers. 2008;90(1):51-60.##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. doi: 10.1006/bbrc.1996.1708. "Tam JP, Lu YA, Yang JL, Chiu KW.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell" "An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclotides as natural anti-HIV agents.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides" DRAMP01374 GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC 33 "Odorranain-D1 (OdD1; Frogs, amphibians, animals)" A6MBK7 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-D1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=16.32 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8.16 g/ml), Bacillus subtilis (MIC=8.16 g/ml).##Yeast: Candida albicans (MIC=4.08 g/ml)." [Ref:17272268]Non-hemolytic activity against rabbit red blood cells Cyclic Free Cyclization(Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.17272268]No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01373 GVLGAVKDLLIGAGKSAAQSVLKTLSCKLSNDC 33 "Odorranain-C1 (OdC1; Frogs, amphibians, animals)" A6MBF6 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-C1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=8.21 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.11 g/ml), Bacillus subtilis (MIC=16.42 g/ml).##Yeast: Candida albicans (MIC=2.05 g/ml)." [Ref:17272268] No detectable hemolytic activity against rabbit red blood cells. Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) [Ref:17272268] There are one disulfide bond between Cys27 and Cys33 L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01372 AALKGCWTKSIPPKPCFGKR 20 "Odorranain-B1 (OdB1; Frogs, amphibians, animals)" E7EKD9 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana hainanensis (Odor frog) (Rana hainanensis) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Homology Not found Odorranain-B1 adopts 5.9 % None "Function: Odorranain-B1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. Tissue specificity: Expressed by the skin glands." "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.21 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=5.83 g/ml), Bacillus subtilis (MIC=1.85 g/ml).##Yeast: Candida albicans (MIC=2.4 g/ml)." [Ref:17272268] No detectable hemolytic activity against rabbit red blood cells. Cyclic Free Free [Ref:17272268] There are one disulfide bond between Cys6 and Cys16 L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01012 RESPSSRMECYEQAERYGYGGYGGGRYGGGYGSGRGQPVGQGVERSHDDNRNQPR 55 Pg-AMP (Gly-rich; Plants) P86030 Not found Not found Psidium guajava (Guava) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-negative bacteria. Does not have antifungal activity against the human and plant pathogenic fungi F. oxysporum, A. fumigatus and R. solani. Subunit structure: Monomer and homodimer. Might act by homodimer formation." "Gram-negative bacteria: Klebsiella sp., Proteus sp., Escherichia coli ATCC 8739 (MIC=72 mg/ml), Klebsiella pneumoniae (MIC=32 mg/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 18448201 Peptides. 2008 Aug;29(8):1271-1279. "Pelegrini PB, Murad AM, Silva LP, Dos Santos RC, Costa FT, Tagliari PD, Bloch C Jr, Noronha EF, Miller RN, Franco OL." Identification of a novel storage glycine-rich peptide from guava (Psidium guajava) seeds with activity against Gram-negative bacteria. DRAMP01018 SIPCGESCVFIPCTVTALLGCSCKSKVCYKN 31 Cyclopsychotride-A (CPT; Plant defensin) P56872 Not found Not found Psychotria longipes "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-21; 8-23; 13-28." "Gram-negative bacteria: Escherichia coli (MIC=1.55 ?M), Pseudomonas aeruginosa (MIC=13.5 ?M), Proteus vulgaris (MIC=13.2 ?M), Klebsiella oxytoca (MIC=5.80 ?M).##Gram-positive bacteria: Staphylococcus aureus (MIC=39.0 ?M), Micrococcus luteus (MIC=48.0 ?M).##Fungi: Candida albicans (MIC>500 ?M), Candida kefyr (MIC=14.0 ?M), Candida tropicalis (MIC=56.5 ?M).##NOTE: Medium with 10 mM phosphate buffer." [Ref.10430870] HD50 = 405 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "There are three disulfide bonds between Cys4 and Cys21, Cys8 and Cys23, Cys13 and Cys28" L [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 1850 M. Not found 10430870##7714530 Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J Nat Prod. 1994 Dec;57(12):1619-1625. "Tam JP, Lu YA, Yang JL, Chiu KW.##Witherup KM, Bogusky MJ, Anderson PS, Ramjit H, Ransom RW, Wood T, Sardana M. " "An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes." DRAMP18193 KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF 34 Cathelicidin-related peptide crotalicidin U5KJM4 Belongs to the cathelicidin family. Not found Crotalus durissus terrificus (South American rattlesnake) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found alpha helical Not found 2MWT resolved by NMR "Function: Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane (By similarity). Hemolytic activities have been observed on mammalian cells. Expressed by the venom gland." "[Ref.25100358]Gram-negative: E.coli ATCC 25922 (MIC=0.25 g/mL),P.aeruginosa (MIC=1 g/mL);##Gram-positive: E.faecalis (MIC=32 g/mL), S.aureus (MIC=32 g/mL)." "[Ref.25100358] Crotalicidin reached 10% hemolysis at 25 M. Even so, extrapolation of existing data indicates that 50% hemolysis would be reached at near-millimolar values, which defines an adequate (~2 log) selectivity window." Cyclic Free Amidation None L No cytotoxicity information found cell membrane 25100358 Amino Acids 46:2561-2571(2014) "Falcao C.B., de La Torre B.G., Perez-Peinado C., Barron A.E.,Andreu D., Radis-Baptista G." Vipericidins: a novel family of cathelicidin-related peptides fromthe venom gland of South American pit vipers. DRAMP01064 AWKLFDDGV 9 Anticancerous peptide 1 (Cr-ACP1; Plants) B3EWE7 Not found Not found Cycas revoluta (Sago palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None "Function: The synthetic peptide inhibits cell proliferation and induces apoptosis in cancer-derived cell lines Hep2 (IC50=1.5 mM) and HCT15 and, to a lesser extent, in non-cancerous NIH/3T3 cells. The mode of action is presumably an arrest in the G0/G1 phase. Antiproliferative, proapoptotic and DNA-binding activities are increased by acetylation at Ala-1 and Lys-3. Has a weak hemolytic activity against mouse erythrocytes. Has antibacterial activity. Antibacterial activity is decreased by acetylation. " "[Ref.21882228]Gram-positive bacteria: Staphylococcus epidermidis (MIC=60 ?M), Bacillus subtilis (MIC=30 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=30 ?M), EEscherichia coli strain ATCC 8739 (MIC=30 ?M)." [Ref.21882228] Hemocompatibility study revealed the effectiveness of both the peptides where it showed no significant lysis of normal RBC cells compare to positive control (Triton X-100). Cr-ACP1 induced hemolysis of 7% at the conentration of 1 mM. Linear Free Free None L [Ref.21882228] IC50 = 1.5 mM in Hep2 (Human epidermoid cancer cells); IC50 = 0.9 mM in HCT15 (human colon carcinoma cells HCT15); Cr-ACP1 induced a cell viability of 66% at the concentration of 4 mM. DNA 21882228 J Cell Biochem. 2012 Jan;113(1):184-193. "Mandal SM, Migliolo L, Das S, Mandal M, Franco OL, Hazra TK." Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties. DRAMP01066 PVVDTTGNNPLQQQEEYYV 19 Kunitz-type serine protease inhibitor 1 (Xb-KTI; Plants) P86930 Not found Not found Xanthosoma sagittifolium (Elephant's ear) (Arum sagittifolium) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Function: Serine protease inhibitor. Displays antimicrobial activity against the Gram-negative bacterium S. typhimurium ATCC 14028. Displays a weak hemolytic activity. [Ref.21520894]Gram-negative bacterium: Salmonella typhimurium ATCC 14028 (MIC=10 ?M). [Ref.21520894] No hemolytic activity was observed for Xb-KTI. The peptide induced a hemolysis of 12% at the highest concentration of 250 g/mL. Values(OD540) were normalized against 100% lysed erythrocytes (0.1% Triton X-100) and PDB (untreated control) Linear Free Free None L No cytotoxicity information found Not found 21520894 J Nat Prod. 2011 May 27;74(5):969-975. "Lima TB, Silva ON, Migliolo L, Souza-Filho CR, Gon?alves EG, Vasconcelos IM, Oliveira JT, Amaral AC, Franco OL." A Kunitz proteinase inhibitor from corms of Xanthosoma blandum with bactericidal activity. DRAMP01081 GLKDIFKAGLGSLVKGIAAHVAN 23 "Alyteserin-1a (toads, amphibians, animals)" No entry found Not found Not found Alytes obstetricans (European midwife toad) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: The alyteserin-1 peptides show selective growth inhibitory activity against the Gram-negative bacterium Escherichia coli. The hemolytic activity against human erythrocytes of all peptides tested is relatively weak. Structural similarity: The alyteserin-1 peptides show limited structural similarity to the ascaphins from the skins of frogs of the family Leiopelmatidae." [Ref.19463738]Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:19463738] LC50 > 100 M against human erthrocytes. Alyteserin-1a induced a hemolysis of 11% at the concentration of 100 M. Linear Free -Amidation None L (to be determined) No cytotoxicity information found Not found 19463738 Peptides. 2009 Jun;30(6):1069-1073. "Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01083 GLKEIFKAGLGSLVKGIAAHVAN 23 "Alyteserin-1b (toads, amphibians, animals)" No entry found Not found Not found Alytes obstetricans (European midwife toad) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Amtimicrobial peptide. (By similarity) Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:19463738] LC50 = 210 M against human erthrocytes. Linear Free -Amidation None L (to be determined) No cytotoxicity information found Not found 19463738 Peptides. 2009 Jun;30(6):1069-1073. "Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01085 GLKEIFKAGLGSLVKGIAAHVAS 23 "Alyteserin-1c (toads, amphibians, animals)" H0USY4 Not found Not found Alytes obstetricans (Common midwife toad) (Bufo obstetricans) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Alpha helix "Solution structural studies in the membrane mimicking environments, sodium dodecyl sulphate (SDS), dodecylphosphocholine (DPC), and 1,2-dihexanoyl-sn-glycero-3-phosphatidylcholine (DHPC) micelles, indicate that these peptides display an alpha helical structure between residues Lys(3) and Val(21).(Ref.1)" 2L5R resolved by NMR. Function: Alyteserin-1c shows selective growth-inhibitory activity against Gram-negative bacteria. Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:19463738] LC50 = 145 M against human erthrocytes. Linear Free -Amidation None L (to be determined) No cytotoxicity information found Not found 21565166##19463738 Biochim Biophys Acta. 2011 Aug;1808(8):1975-1984.##Peptides. 2009 Jun;30(6):1069-1073. "Subasinghage AP, O'Flynn D, Conlon JM, Hewage CM.##Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." Conformational and membrane interaction studies of the antimicrobial peptide alyteserin-1c and its analogue [E4K]alyteserin-1c.##The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01088 GFKEVLKADLGSLVKGIAAHVAN 23 "Alyteserin-1Ma (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Alyteserin-1Ma has lower antimicrobial potencies (MIC>200 ?M). Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=214 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=214 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01089 GFKEVLKAGLGSLVKGIPAHVAN 23 "Alyteserin-1Mb (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Alyteserin-2Ma has lower antimicrobial potencies (MIC>200 ?M). Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=217 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=434 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01090 FIGKLISAASGLLSHL 16 "Alyteserin-2Ma (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli and Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 150 microM. Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=38.4 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=9.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01096 GIGSAILSAGKSALKGLAKGLAEHFAN 27 "Bombinin-like peptide 2 (BLP-2; toads, amphibians, animals)" P29003 Belongs to the bombinin family Not found Bombina orientalis (Oriental fire-bellied toad) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria. Tissue specificity: Expressed by the skin glands." "[Ref.1744108]Gram-negative bacterium: 58% inhibition Neisseria meningitidis 118V C (MIC=20 ?g/ml), 98% inhibition Neisseria meningitidis 15240 IAI (MIC=20 ?g/ml), 98% inhibition Neisseria meningitidis 126E IC1 (MIC=20 ?g/ml), 97% inhibition Neisseria gonorrhoeoe F62 (MIC=20 ?g/ml), 99% inhibition Neisseria Iactamica 15323 (MIC=20 ?g/ml), 100% inhibition Neisseria Iactamica 15215A (MIC=20 ?g/ml), 95% inhibition Neisseria cinerea 15461 (MIC=20 ?g/ml)." [Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes. Cyclic Free Amidation None L No cytotoxicity information found Not found 1744108 J. Biol. Chem. 1991; 266: 23103-23111. "Gibson BW, Tang D, Mandrell R, Kelly M, Spindel ER." "Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis." DRAMP03017 FMPIIGRLMSGSL 13 "VESP-VB1 (Insects, animals)" No entry found Not found Not found vespine wasps Vespa bicolor "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has antimicrobial activities against standard strains and strong antimicrobial ability against drug-resistant strains. Among the tested drug-resistant strains, Pseudemonas aeruginosa and Staphylococcus aureus were the most sensitive for this kind of antimicrobial peptide. Has a little hemolytic activity." "[Ref.18723059] Gram-negative bacterium: Escherichia coli ATCC25922(MIC=7.5g/ml), Escherichia coli 23A(MIC=7.5g/ml), Escherichia coli 27A(MIC=15.0g/ml), Pseudemonas aeruginosa 3A(MIC=3.75g/ml), Pseudemonas aeruginosa 7A(MIC=3.75g/ml), ;## Gram-positive bacterium: Staphylococcus aureus ATCC2592(MIC=1.9g/ml), Staphylococcus aureus 6A(MIC=3.75g/ml), Staphylococcus aureus 15A(MIC=1.0g/ml);## Fungus: Candida albicans ATCC2002(MIC=30.0g/ml)" "[Ref.18723059] VESP-VB1 had a little hemolytic activity of 10.2% against rabbit red blood cells, and of 3.2% against human red blood cells with peptide concentration up to 200 g/ml" Linear Free Free None L No cytotoxicity information found Not found 18723059 Peptides. 2008 Nov;29(11):1887-1892. "Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, Yu H." Antimicrobial peptides from the venoms of Vespa bicolor Fabricius. DRAMP01098 GIGAAILSAGKSALKGLAKGLAEHF 25 "Bombinin-like peptide 3 (BLP-3; toads, amphibians, animals)" P29004 Belongs to the bombinin family Not found Bombina orientalis (Oriental fire-bellied toad) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Alpha helix Not found None "Function: Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria. Tissue specificity: Expressed by the skin glands." "[Ref.1744108]Gram-postive bacterium:Bacillus megaterium BmII (MIC=0.3 ?M), Staphylococcus aureus Cowan1 (MIC=1.7 ?M);##Gram-negative bacterium:59% inhibition Neisseria meningitidis 118V C (MIC=20 ?g/ml), 99% inhibition Neisseria meningitidis 15240 IAI (MIC=20 ?g/ml), 99% inhibition Neisseria meningitidis 126E IC1 (MIC=20 ?g/ml), 99% inhibition Neisseria gonorrhoeoe F62 (MIC=20 ?g/ml), 97% inhibitionNeisseria Iactamica 15323 (MIC=20 ?g/ml), 100% inhibition Neisseria Iactamica 15215A (MIC=20 ?g/ml), 97% inhibition Neisseria cinerea 15461 (MIC=20 ?g/ml), Escherichia coli D21 (MIC=1.7 ?M), Escherichia coli D22 (MIC=1.5 ?M), Yersinia pseudotubercolosis (MIC=0.6 ?M), Pseudomonas aeruginosa ATCC 15692 (MIC=9.2 ?M);##Fungus:Candida albicans (MIC=0.4 ?M)." [Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes. Cyclic Free Amidation None L No cytotoxicity information found Not found 1744108 J Biol Chem. 1991 Dec 5;266(34):23103-23111. "Gibson BW, Tang DZ, Mandrell R, Kelly M, Spindel ER." "Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis." DRAMP02090 FLPMLAGLAASMVPKFVCLITKKC 24 "Brevinin-1Lb (Frogs, amphibians, animals)" P82826 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana luteiventris (Spotted frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=8 M);##Gram-negative bacterium: Escherichia coli (MIC=16 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free There is a disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP02091 FLPFIAGMAAKFLPKIFCAISKKC 24 "Brevinin-1Ba (Frogs, amphibians, animals)" P82833 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana berlandieri (Rio Grande leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=2 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01518 GILSLFTGGIKALGKTLFKMAGKAGAEHLACKATNQC 37 "Esculentin-2L (Frogs, amphibians, animals)" P82827 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana luteiventris (Great Basin spotted frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=3 M);##Gram-negative bacterium: Escherichia coli (MIC=6 M).##Yeast: Candida albicans (MIC=53 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01517 GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC 37 "Esculentin-2P (Frogs, amphibians, animals)" P82846 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana pipiens (northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antiviral" Protein level Not found Not found None "Function: Antibacterial activity against Gram-negative bacteria. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-negative bacterium: Escherichia coli (MIC=10 M).##[Ref.11601906]Virus:##Frog Virus 3: 90% inhibition at 500 ?M;##Channel Catfish Virus: 90% inhibition at 50 ?M. No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found in the reference(s) presented Not found 11601906##10651828 Virology. 2001 Sep 30;288(2):351-7.##Eur J Biochem. 2000 Feb;267(3):894-900. "Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.##Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.##Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01516 GLFSILRGAAKFASKGLGKDLTKLGVDLVACKISKQC 37 "Esculentin-2B (Frogs, amphibians, animals)" P82839 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana berlandieri (Rio Grande leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=1 M);##Gram-negative bacterium: Escherichia coli (MIC=1 M).##Yeast: Candida albicans (MIC=29 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP02077 FLPIIAGIAAKVFPKIFCAISKKC 24 "Brevinin-1Pb (Frogs, amphibians, animals)" Q8QFQ5 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana pipiens (Northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=5 M);##Gram-negative bacterium: Escherichia coli (MIC=14 M).##Yeast: Candida albicans (MIC=7 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 10651828##12413397 Eur J Biochem. 2000 Feb;267(3):894-900.##Biochem J. 2003 Apr 1;371(Pt 1):125-130. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.##Chen T, Farragher S.M, Bjourson A.J, Orr D.F, Rao P, Shaw C." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.##Granular gland transcriptomes in stimulated amphibian skin secretions." DRAMP01162 AGRGKQGGKVRAKAKTRSSRAGLQFPVGRVHRLLRKGNY 39 "Buforin-1 (Buforin I; Fragment of Histone H2A; toads, amphibians, animals)" P55897 Belongs to the histone H2A family Not found Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. PTM: Monoubiquitination of C-terminus gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties." "Gram-positive bacteria: Bacillus subtilis (MIC=4 ?g/ml), Staphylococcus aureus (MIC=4 ?g/ml), Streptococcus mutans (MIC=8 ?g/ml), Streptococcus pneumoniae (MIC=4 ?g/ml), Pseudomonas putida (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=4 ?g/ml), Serratia sp. (MIC=8 ?g/ml).##Fungi: Candida albicans (MIC=4 ?g/ml), Cryptococcus neoformans (MIC=4 ?g/ml), Saccharomyces cerevisiae (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free The residue at position 5 is N6-(2-hydroxyisobutyryl)lysine or N6-acetyllysine. The residue at position 9 is N6-(2-hydroxyisobutyryl)lysine or N6-lactoyllysine or N6-succinyllysine. The Lys13 has a interchain with G-Cter in ubiquitin. The Lys15 has a interchain with G-Cter in ubiquitin. The residue at position 36 is N6-(2-hydroxyisobutyryl)lysine. L No cytotoxicity information found DNA 8573171##8946958 Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.##FEBS Lett. 1996 Nov 25;398(1):87-90. "Park C.B, Kim M.S, Kim S.C.##Yi G.-S, Park C.B, Kim S.C, Cheong C." A novel antimicrobial peptide from Bufo bufo gargarizans.##Solution structure of an antimicrobial peptide buforin II. DRAMP01163 TRSSRAGLQFPVGRVHRLLRK 21 "Buforin-2 (Buforin II; Fragment of Histone H2A; toads, amphibians, animals)" P0DQL2 Belongs to the histone H2A family Not found Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed selective anticancer activity against 62 cancer cell lines (Lee 2008 Cancer Lett 271: 47-51). Buforin II is more potent than buforin I. PTM: Monoubiquitination of C-terminus gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties." "Gram-positive bacteria: Bacillus subtilis (MIC=2 ?g/ml), Staphylococcus aureus (MIC=4 ?g/ml), Streptococcus mutans (MIC=2 ?g/ml), Streptococcus pneumoniae (MIC=4 ?g/ml), Pseudomonas putida (MIC=2 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=1 ?g/ml), Serratia sp. (MIC=4 ?g/ml).##Fungi: Candida albicans (MIC=1 ?g/ml), Cryptococcus neoformans (MIC=1 ?g/ml), Saccharomyces cerevisiae (MIC=1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free The residue at position 21 is N6-(2-hydroxyisobutyryl)lysine L No cytotoxicity information found DNA 8573171##8946958 Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.##FEBS Lett. 1996 Nov 25;398(1):87-90. "Park C.B, Kim M.S, Kim S.C.##Yi G.-S, Park C.B, Kim S.C, Cheong C." A novel antimicrobial peptide from Bufo bufo gargarizans.##Solution structure of an antimicrobial peptide buforin II. DRAMP01164 GIGALSAKGALKGLAKGLAEHFAN 24 "Bombinin (toads, amphibians, animals)" P01505 Not found Not found Bombina variegata (Yellow-bellied toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial and hemolytic activities. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation. Caution: Residue 20 is assigned as E by similarity to other bombin sequences instead of Z (Glutamic acid or Gutamine) given " [Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=14 ?M). "[Ref.8223491] The lethal concentration (LC, the lowest concentration that inhibits growth) was over 50 M" Linear Free Amidation None L No cytotoxicity information found Not found PubMed ID is not available##8223491 Monatsh. Chem. 1970;101:182-189.##EMBO J. 1993; 12:4829-4832. "Csordas A, Michl H.##Mignogna G, Simmaco M, Kreil G, Barra D." Isolation and structural resolution of a haemolytically active polypeptide from the immune secretion of a European toad.##Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata. DRAMP01167 GILDAIKAIAKAAG 14 Hylaseptin-P1 (HSP1) P84292 Not found Not found Hyla punctata (Polka-dot tree frog) (Spotted tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Has antibacterial and antifungal activity. A weak hemolytic activity has been detected. "[Ref.14715660]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.1-8.0 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=48.8-64.0 ?g/ml), Escherichia coli ATCC 25922 (MIC=24.4-32.0 ?g/ml)." [Ref.14715660] HSP1 MIC concentration (256 g/mL = 195.2 M) produced 4.7% hemolysis against human erythrocytes. Linear Free [Ref.11297740] Free / [Ref.32828849] Amidation None L No cytotoxicity information found Not found 14715660##32828849 "J Biol Chem. 2004 Mar 26;279(13):13018-13026. ##Biochim Biophys Acta Biomembr . 2021 Jan 1;1863(1):183449. doi: 10.1016/j.bbamem.2020.183449. Epub 2020 Aug 21." "Prates MV, Sfora ML, Regis WC, Leite JR, Silva LP, Pertinhez TA, Ara?jo AL, Azevedo RB, Spisni A, Bloch C Jr.##Isabela P Gomes 1, Talita L Santos 1, Amanda N de Souza 1, Lcio O Nunes, Gabriele A Cardoso, Carolina O Matos, Lvia M F Costa, Luciano M Li?o, Jarbas M Resende, Rodrigo M Verly" The NMR-derived solution structure of a new cationic antimicrobial peptide from the skin secretion of the anuran Hyla punctata.##Membrane interactions of the anuran antimicrobial peptide HSP1-NH 2: Different aspects of the association to anionic and zwitterionic biomimetic systems DRAMP01170 NLVSGLIEARKYLEQLHRKLKNCKV 25 "Distinctin 2 (Frogs, amphibians, animals)" No entry found Not found Not found Phyllomedusa distincta (Tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Alpha helix (1 helices; 17 residues) Not found 1XKM resolved by NMR Comment: Distinctin is constituted of two different polypeptide chains connected by an intermolecular disulphide bridge. The entry is the chain 2 of Distinctin "Note: Distinctin chain 2 links to Distinctin chain 1 to form a heterodimeric peptide to exert antibacterial function. ##Gram-positive bacteria: Enterococcus faecalis (MIC=14.5 ?M), Staphylococcus aureus (MIC=28.0 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=28.0 ?M), Escherichia coli (MIC=14.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free There is an intermolecular disulphide bridge between Distinctin chain 1 (Cys19) and Distinctin chain 2 (Cys22). L No cytotoxicity information found Not found 11297740 FEBS Lett. 2001 Apr 6;494(1-2):85-89. "Batista CV, Scaloni A, Rigden DJ, Silva LR, Rodrigues Romero A, Dukor R, Sebben A, Talamo F, Bloch C." A novel heterodimeric antimicrobial peptide from the tree-frog Phyllomedusa distincta. DRAMP01174 GLLDFVTGVGKDIFAQLIKQI 21 "Ocellatin-4 (Frogs, amphibians, animals)" P85090 Not found Not found Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has hemolytic activity against human erythrocytes (HC50=14.3 ?M). Has antibacterial activity. Tissue specificity: Expressed by the skin dorsal glands." [Ref.17884127]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=64 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=64 ?M). [Ref.17884127] HC50 = 14.3 M against human O+ red blood cells Linear Free Amidation None L No cytotoxicity information found Not found 17884127 Toxicon 2007; 50: 1095-1104. Nascimento A et al Castro MS. "Purification, characterization and homology analysis of ocellatin 4, a cytolytic peptide from the skin secretion of the frog Leptodactylus ocellatus." DRAMP01177 GVVDILKGAAKDIAGHLASKVMNKL 25 "Ocellatin-F1 (Fallaxin; Frogs, amphibians, animals)" No entry found Not found Not found Leptodactylus fallax (Mountain chicken frog) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has low hemolytic activity of fallaxin (HC50>200 ?M). "[Ref.15544856]Gram-negative bacteria: Escherichia coli (MIC=40 ?M), Pseudomonas aeruginosa (MIC=80 ?M), Enterobacter cloacae (MIC=20 ?M), Klebsiella pneumoniae (MIC=80 ?M)." [Ref:15544856]HC50>200 M hemolytic activity of fallaxin Linear Free Amidation Free L [Ref.15544856]No cytotoxicity information found Not found 15544856 Regul Pept. 2005 Jan 15;124(1-3):173-178. "Rollins-Smith LA, King JD, Nielsen PF, Sonnevend A, Conlon JM." An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae). DRAMP01182 GLLDTLKGAAKNVVGSLASKVMEKL 25 "Ocellatin-P1 (Pentadactylin; Frogs, amphibians, animals)" No entry found Not found Not found Leptodactylus pentadactylus (South American bullfrog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Klebsiella pneumoniae KK3 9904 (MIC=100 ?M), Enterobacter cloacae HNTCC 53001 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus epidermidis RP62A (MIC=100 ?M), Streptococcus Group B HNTCC 80130 (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16236555]No cytotoxicity information found Not found 16236555 Comp Biochem Physiol C Toxicol Pharmacol. 2005 Aug;141(4):393-397. "King JD, Al-Ghaferi N, Abraham B, Sonnevend A, Leprince J, Nielsen PF, Conlon JM." Pentadactylin: an antimicrobial peptide from the skin secretions of the South American bullfrog Leptodactylus pentadactylus. DRAMP01184 GVLDILKGAAKDLAGHVATKVI 22 "SPX(1-22)(truncated peptide of Syphaxin; Frogs, amphibians, animals)" No entry found Not found Not found Leptodactylus syphax (Burgundy thin-toed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus ATCC 29213 (MIC=14.6 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=40.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17628627]No cytotoxicity information found Not found 17628627 Toxicon. 2007 Sep 15;50(4):572-580. "Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F." Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax. DRAMP01185 GVLDILKGAAKDLAGH 16 "SPX(1-16)(truncated peptide of Syphaxin; Frogs, amphibians, animals)" No entry found Not found Not found Leptodactylus syphax (Burgundy thin-toed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus ATCC 29213 (MIC=40.5 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.1 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17628627]No cytotoxicity information found Not found 17628627 Toxicon. 2007 Sep 15;50(4):572-580. "Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F." Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax. DRAMP01188 LALKSGGWLRLFGLKDKKH 19 "Chensinin-1ZHa (Frogs, amphibians, animals)" No entry found Not found Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=9 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=35 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.22943378]No cytotoxicity information found Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01189 ATNIPFKVHFRCKAAFC 17 "Andersonin-W1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC>47 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>47 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=47 ?g/ml)." [Ref:22029824] It has no hemolytic activity against human red blood cells Cyclic Free Cyclization (Cys12 and Cys17) Disulfide bond between Cys12 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01190 AVNIPFKVHFRCKAAFC 17 "Andersonin-W2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=20.2 ?g/ml)." [Ref:22029824] It has no hemolytic activity against human red blood cells Cyclic Free Cyclization (Cys12 and Cys17) Disulfide bond between Cys12 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01191 GLFSKFAGKGIVNFLIEGVE 20 "Andersonin-X1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.3 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30.5 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01192 FLPKLFAKITKKNMAHIR 18 "Andersonin-Y1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=3.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=1.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=1.6 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01194 TSRCIFYRRKKCS 13 "Andersonin-C1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Show hemolytic activity against human red blood cells and obvious insulin-stimulating activity at the concentration of 50 ??g/mL. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>120 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml)." [Ref:22029824] It has 15.22.1% hemolytic activity at 50g/ml against human red blood cells Cyclic Free Free Disulfide bond between Cys4 and Cys12. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01195 FIFPKKNIINSLFGR 15 "Andersonin-D1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Weakly active against bacteria and fungi. Andersonin-D1 showes obvious insulin-stimulating activity at the concentration of 50 ??g/mL. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>126 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=16 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=16 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01199 RFIYMKGFGKPRFGKR 16 "Hejiangin-A1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana hejiangensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Hejiangin-A1 showes killing effects against the tested strains. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=25 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=25 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01200 IPWKLPATFRPVERPFSKPFCRKD 24 "Hejiangin-F1 (frog, amphibians, animals)" No entry found Not found Not found Odorrana hejiangensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=100 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=100 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=100 ?g/ml)." [Ref:22029824]Non-hemolytic activity against human red blood cells Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01201 AAPRGGKGFFCKLFKDC 17 "Schmackerin-C1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana schmackeri "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Schmackerin-C1 showes killing effects against the tested strains. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=50 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=50 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys11 and Cys17) Disulfide bond between Cys11 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01208 SIITMTKEAKLPQLWKQIACRLYNTC 26 "Pleurain-A1 (Pleurain A1; Frogs, amphibians, animals)" "A8DY01, A8DY00, A8DY02, A8DY03, A8DY04, A8DY09, A8DY10, A8DY15" Not found Not found Rana pleuraden (Yunnan pond frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has little hemolytic activity on red blood cells. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=30 ?g/ml);##Gram-positive bacteria: Bacillus dysenteriae (MIC=120 ?g/ml), Staphylococcus aureus ATCC 2592 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml).." [Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 g/ml Cyclic Free Cyclization (Cys20 and Cys26) Disulfide bond between Cys20 and Cys26. L No cytotoxicity information found Not found 17764786 Peptides. 2007 Oct;28(10):2069-2074. "Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K." A new family of antimicrobial peptides from skin secretions of Rana pleuraden DRAMP01209 SIITMTKEAKLPQSWKQIACRLYNTC 26 "Pleurain-A2 (Pleurain A2; Frogs, amphibians, animals)" A8B5P0 Not found Not found Rana pleuraden (Yunnan pond frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has little hemolytic activity on red blood cells. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=30 ?g/ml);##Gram-positive bacteria: Bacillus dysenteriae (MIC=60 ?g/ml), Staphylococcus aureus ATCC 2592 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml)." [Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 g/ml Cyclic Free Cyclization (Cys20 and Cys26) Disulfide bond between Cys20 and Cys26. L No cytotoxicity information found Not found 17764786 Peptides. 2007 Oct;28(10):2069-2074. "Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K." A new family of antimicrobial peptides from skin secretions of Rana pleuraden. DRAMP01214 FLGAIAAALPHVINAVTNAL 20 "Kassinatuerin-2Ma (Frogs, amphibians, animals)" No entry found Not found Not found Kassina maculata (African hyperoliid frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Alpha helix "Secondary structure prediction analysis revealed that virtually the entire structure of each kassinatuerin-2 related peptide is composed of alpha-helix, the helix was not amphipathic like many other amphibian skin antimicrobial peptides, in which there is a hydrophobic face and a positively charged faces the latter presumably interacting with the negatively charged glycocalyx of cell membranes." None "Function: Natural kassinatuerin-2Ma and their synthetic replicates possessed relatively potent growth inhibitory activity against the Gram-positive bacterium, S. aureus, but were ineffective against the Gram-negative bacterium, E. coli at concentrations up to 200 ?M and were relatively ineffective against the pathogenic yeast, C. albicans (120 ?M). Also possessed hemolytic activity as demonstrated using horse erythrocytes." [Ref.19427345]Gram-positive bacterium: Staphylococcus aureus (NCTC 10788) (MIC=16 ?M);##Gram-negative bacterium: Escherichia coli (NCTC 10418) (MIC>200 ?M) (MIC=120 ?M);##Yeast: Candida albicans (NCPF 1467) (MIC=120 ?M). "[Ref:19427345]18% hemolytic activity at 16 M, 45C50% hemolytic activity at 120 M against horse erythrocytes" Linear Free Amidation Free L [Ref.19427345]No cytotoxicity information found Not found 19427345 Peptides. 2009 Aug;30(8):1428-1433. "Wang L, Zhou M, McGrath S, Chen T, Gorman SP, Walker B, Shaw C." "A family of kassinatuerin-2 related peptides from the skin secretion of the African hyperoliid frog, Kassina maculata." DRAMP01218 GFMKYIGPLIPHAVKAISDLI 21 "Kassinatuerin-1 (Frogs, amphibians, animals)" P0C010 Not found Not found Kassina senegalensis (Senegal running frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Shows broad-spectrum antimicrobial activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-negative bacteria: Escherichia coli (MIC=6.25 ?M), Klebsiella pneumoniae (MIC=25 ?M), Enterobacter cloacae (MIC=6.25 ?M), Pseudomonas aeruginosa (MIC=25 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 ?M), Staphylococcus epidermidis (MIC=6.25 ?M), Enterococcus faecalis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15885852]Display cytotoxicity against L929 fibroblasts (LD50=12M). Not found 10679222##15885852 Biochem Biophys Res Commun. 2000 Feb 16;268(2):433-436.##Peptides. 2005 Nov;26(11):2104-2110. "Mattute B, Knoop FC, Conlon JM.##Conlon JM, Abraham B, Galadari S, Knoop FC, Sonnevend A, P?l T." "Kassinatuerin-1: a peptide with broad-spectrum antimicrobial activity isolated from the skin of the hyperoliid frog, Kassina senegalensis.##Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives." DRAMP01222 GFMDTAKNVAKNVAVTLIDKLRCKVTGGC 29 "Palustrin-2AJ1 (PL2AJ1; Frogs, amphibians, animals)" G3ETQ3 Not found Not found Amolops jingdongensis (Chinese torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Has hemolytic activity, low cytotoxicity and low antioxidant activity. Tissue specificity: Expressed by the skin glands. PTM: One disulfide bond (C23-C29) and Cleavage on pair of basic residues." "[Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=20 ?M), Enterococcus faecalis ATCC29212 (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=13 ?M), Bacillus pyocyaneus CMCCB1010 (MIC=20 ?M), Pseudomonas aeruginosa ATCC27853 (MIC=33 ?M), Bacillus dysenteriae (MIC=50 ?M)." [Ref:21816202] IC50=135 M against human and rabbit erythrocytes Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L [Ref.21816202] Cytotoxicity: the K562 (IC50=58M) and HT29 mammalian cell lines(IC50=57M). Not found 21816202 Biochimie. 2012 Feb;94(2):328-334. "Chen Z, Yang X, Liu Z, Zeng L, Lee W, Zhang Y." "Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis." DRAMP01227 ALFSILRGLKKLGNMGQAFVNCKIYKKC 28 "Palustrin-1b (Frogs, amphibians, animals)" P84275 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys22 and Cys28) Disulfide bond between Cys22 and Cys28. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01228 ALSILRGLEKLAKMGIALTNCKATKKC 27 "Palustrin-1c (Frogs, amphibians, animals)" "P84276, A7WNV8" Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial activity against Gram-negative bacteria E. coli. Possesses insulin-releasing activity. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=28 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys21 and Cys27) Disulfide bond between Cys21 and Cys27. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01229 ALSILKGLEKLAKMGIALTNCKATKKC 27 "Palustrin-1d (Frogs, amphibians, animals)" P84277 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=28 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys21 and Cys27) Disulfide bond between Cys21 and Cys27. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01231 GFFSTVKNLATNVAGTVIDTLKCKVTGGCRS 31 "Palustrin-2b (Frogs, amphibians, animals)" "P84279, D3UA82" Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=78 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01232 GFMDTAKNVAKNVAATLLDKLKCKITGGC 29 "Palustrin-2ISc (Frogs, amphibians, animals)" G3XHN9 Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?M), Bacillus subtilis (MIC=12.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21867685 Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-677. "Iwakoshi-Ukena E, Soga M, Okada G, Fujii T, Sumida M, Ukena K." Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning. DRAMP01233 GFLSTVKNLATNVAGTVIDTLKCKVTGGCRS 31 "Palustrin-2c (Frogs, amphibians, animals)" P84280 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=120 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01234 GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLNNIGNTGCNEDEC 48 "Palustrin-3a (Frogs, amphibians, animals)" P84281 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=1 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys43 and Cys48) Disulfide bond between Cys43 and Cys48. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01235 GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLSNIGNTGCNEDEC 48 "Palustrin-3b (Frogs, amphibians, animals)" P84262 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=1 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys43 and Cys48) Disulfide bond between Cys43 and Cys48. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01237 GFMDTAKNVAKNVAVTLLDKLKCKITGGC 29 "Palustrin-2ISa (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana ishikawae "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?M), Staphylococcus aureus (MRSA) (MIC=100 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01238 GLWNSIKIAGKKLFVNVLDKIRCKVAGGCKTSPDVE 36 "Palustrin-2SIb (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana ishikawae "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), S. aureus (MRSA) (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K.2011." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-2 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP01244 FFPIGVFCKIFKTC 14 "Japonicin-1 (Frogs, amphibians, animals)" P83305 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana japonica (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin dorsal glands. Gram-negative bacterium: Escherichia coli (MIC=30 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys8 and Cys14) Disulfide bond between Cys8 and Cys14. L No cytotoxicity information found Not found 11835990 Peptides. 2002;23:419-425 "Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM." Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica. DRAMP01245 FFPLALLCKVFKKC 14 "Japonicin-1CDYa (Frogs, amphibians, animals)" B3VZU2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Antimicrobial peptide. Lacks hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." [Ref.19539775]Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:19539775] HC50>300 M against human red blood cells Cyclic Free Cyclization (Cys8 and Cys14) Disulfide bond between Cys8 and Cys14. L No cytotoxicity information found Not found 19539775 Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178. "Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH." "Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii." DRAMP01246 FGLPMLSILPKALCILLKRKC 21 "Japonicin-2 (Frogs, amphibians, animals)" P83306 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana japonica (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=20 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys21) Disulfide bond between Cys14 and Cys21. L No cytotoxicity information found Not found 11835990 Peptides. 2002;23:419-425. "Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM." Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica. DRAMP01249 FLIGMTQGLICLITRKC 17 "Dybowskin-2 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Dybowskin-2 has hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=15 ?g/ml), Bacillus subtilis ATCC6633 (MIC=25 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=25 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 ?g/ml), Escherichia coli KCTC2433 (MIC=60 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=60 ?g/ml), Proteus mirabilis ATCC25933 (MIC>100 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=100 ?g/ml)." [Ref:17698251] It has 10.99% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys11 and Cys17) Disulfide bond between Cys11 and Cys17. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01250 GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC 33 "Dybowskin-3 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Dybowskin-3 has hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=39 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=50 ?g/ml), Bacillus subtilis ATCC6633 (MIC=60 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=60 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=15 ?g/ml), Escherichia coli KCTC2433 (MIC=15 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC>100 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=100 ?g/ml)." [Ref:17698251] It has 1.86% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01251 VWPLGLVICKALKIC 15 "Dybowskin-4 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Dybowskin-4 has relatively greater hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=1.56 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=3.13 ?g/ml), Bacillus subtilis ATCC6633 (MIC=6.25 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=30 ?g/ml), Escherichia coli KCTC2433 (MIC=15 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=25 ?g/ml)." [Ref:17698251] It has 47.58% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys9 and Cys15) Disulfide bond between Cys9 and Cys15. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01252 GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC 38 "Dybowskin-5 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Dybowskin-5 has hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=50 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 ?g/ml), Escherichia coli KCTC2433 (MIC=60 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=50 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=50 ?g/ml)." [Ref:17698251] It has 17.84% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01254 IIPLPLGYFAKKT 13 "Dybowskin-1CDYa (Frogs, amphibians, animals)" B5A9S9 Not found Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M);##Gram-negative bacterium: Escherichia coli (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19539775]No cytotoxicity information found Not found 19539775 Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178. "Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH." "Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii." DRAMP01255 SAVGRHGRRFGLRKHRKH 18 "Dybowskin-2CDYa (Chensinin-1; Frogs, amphibians, animals)" B5A9T1 Not found Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Antimicrobial peptide. Has activity against the Gram-positive bacteria: S. aureus and the Gram-negative bacteria E. coli. Lacks hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.19539775] Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-negative bacterium: Staphylococcus aureus (MIC=6 ?M).##[Ref.19341344] Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 ?M), Bacillus cereus (MIC=14.4 ?M), Streptococcus lactis (MIC=14.4 ?M)." [Ref:19539775]HC50>300 M against human red blood cells Linear Free Free Free L [Ref.19539775]No cytotoxicity information found##[Ref.19341344]No cytotoxicity information found Not found 19539775##19341344 Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.##Zoolog Sci. 2009 Mar;26(3):220-226. "Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.##Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y." "Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.##Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis." DRAMP01257 GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV 33 "Dermadistinctin-K (DD K; Frogs, amphibians, animals)" P83638 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix Not found "2K9B, 2JX6 resolved by NMR." "Function: Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=4.7 ?M), Enterococcus faecalis (MIC>19 ?M);Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2.4 ?M), Escherichia coli (MIC=0.6 ?M).##Fungi: Candida tropicalis (MIC=10.1 ?M), Candida guilliermondii (MIC=20.3 ?M), Candida albicans (MIC=20.3 ?M), Candida albicans ATCC 1023 (MIC=10.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]No cytotoxicity information found liposomes 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01258 ALWKTLLKNVGKAAGKAALNAVTDMVNQ 28 "Dermadistinctin-L (DD L; Frogs, amphibians, animals)" P83639 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix Not found None "Function: Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes. Show little hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." "[Ref.10477123]Gram-positive bacteria: Staphylococcus aureus (MIC=1.3 ?M), Enterococcus faecalis (MIC=10 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=40 ?M), Escherichia coli (MIC=2.5 ?M);##[Ref.17442605]Fungi: Candida tropicalis (MIC=10.9 ?M), Candida guilliermondii (MIC=21.8 ?M), Candida albicans (MIC=21.8 ?M), Candida albicans ATCC 1023 (MIC=10.9 ?M)." [Ref:10477123]Show some hemolytic starting at 12.5 M against human blood Linear Free Free Free L [Ref.10477123]No cytotoxicity information found liposomes 10477123##12379643##17409003##17442605 Peptides. 1999;20(6):679-686.##J Biol Chem. 2002 Dec 20;277(51):49332-49340.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):329-335.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):336-343. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr.##Brand GD, Leite JR, Silva LP, Albuquerque S, Prates MV, Azevedo RB, Carregaro V, Silva JS, S?? VC, Brand??o RA, Bloch C Jr.##Silva LP, Leite JR, Brand GD, Regis WB, Tedesco AC, Azevedo RB, Freitas SM, Bloch C Jr.##Leite JR, Brand GD, Silva LP, K??ckelhaus SA, Bento WR, Ara??jo AL, Martins GR, Lazzari AM, Bloch C Jr." "Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: liposomes fusion and/or lysis investigated by fluorescence and atomic force microscopy.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity." DRAMP01259 ALWKTMLKKLGTMALHAGKAAFGAAADTISQ 31 "Dermadistinctin-M (DD M; Frogs, amphibians, animals)" P83640 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Amphibian defense peptide. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=38 ?M), Enterococcus faecalis (MIC>38 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=38 ?M), Escherichia coli (MIC=9.7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]No cytotoxicity information found Not found 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01260 ALWKNMLKGIGKLAGQAALGAVKTLVGAES 30 "Dermadistinctin-Q1 (DD Q1; Frogs, amphibians, animals)" P83641 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Amphibian defense peptide. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=2.7 ?M), Enterococcus faecalis (MIC=22 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=5.4 ?M), Escherichia coli (MIC=1.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]No cytotoxicity information found Not found 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01261 GLWSKIKEAAKTAGLMAMGFVNDMV 25 "Dermadistinctin-Q2 (DD Q2; Frogs, amphibians, animals)" P83642 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Amphibian defense peptide. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=22 ?M), Enterococcus faecalis (MIC=11 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=22 ?M), Escherichia coli (MIC=5.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]To produce hemolysis more than 38 M peptide concentrations was required. Not found 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01301 FLSLIPHAINAVSAIAKHN 19 "Phylloseptin-1 (PS-1; Frogs, amphibians, animals)" P84566 Not found psn1 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (1 helices; 14 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JQ0 resolved by NMR. "Function: Atomic force microscopy experiments indicated that the bacteriolytic properties of these peptides might be related to their disruptive action on the cell membrane. PS-1 did not exhibit significant hemolytic activity on human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.15752569]Gram-positive bacteria: Staphylococcus aureus (MIC=7.9 ?M), Enterococcus faecalis (MIC=4.0 ?M);##Gram-negative bacteria: Escherichia coli (MIC=7.9 ?M), Psecdomonas aeruginosa (MIC=4 ?M), Psecdomonas aeruginosa wt (MIC=3 ?M)." "[Ref:15752569]0.3% hemolytic activity at 4 M, 0.57% hemolytic activity at 8 M, 0.6% hemolytic activity at 16 M, 0.98% hemolytic activity at 32 M, 1.98% hemolytic activity at 64 M against human red blood cells" Linear Free Amidation Free L [REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01302 FLSLIPHAINAVSTLVHHF 19 "Phylloseptin-2 (PS-2; Frogs, amphibians, animals)" "P85881, P84567, Q0VZ43" Not found psn2 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 14 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JPY resolved by NMR. "Function: Has antimicrobial activity. PS-2 did not exhibit significant hemolytic activity on human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.18656510][ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=15.1 ?M);##Gram-negative bacteria: Escherichia coli (MIC=60.4 ?M), Klebsiella pneumoniae (MIC=60.4 ?M), Pseudomonas aeruginosa (MIC=60.4 ?M);##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=7.6 ?M), S. agalactiae (MIC=1.9 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=60.4 ?M), A. calcoaceticus (MIC=3.7 ?M);##Fungi: Candida albicans (MIC=15.1 ?M)." "[Ref:15752569]0.1% hemolytic activity at 4 M, 0.28% hemolytic activity at 4 M, 0.7% hemolytic activity at 8 M, 0.8% hemolytic activity at 16 M, 1.05% hemolytic activity at 32 M, 2.05% hemolytic activity at 64 M against human red blood cells" Linear Free Amidation Free L [REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01303 FLSLIPHAINAVSALANHG 19 "Phylloseptin-3 (PS-3; Frogs, amphibians, animals)" P84568 Not found psn3 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 11 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JQ1 resolved by NMR. "Function: Has antimicrobial activity (By similarity). Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=32.9 ?M);##Gram-negative bacteria: Escherichia coli (MIC=65.6 ?M), Klebsiella pneumoniae (MIC=65.6 ?M), Pseudomonas aeruginosa (MIC=65.6 ?M). NOTE: Initial inoculum of 108 cells/Ml.##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=8.2 ?M), S. agalactiae (MIC=4.1 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=32.8 ?M), A. calcoaceticus (MIC=4.1 ?M).##Fungi: Candida albicans (MIC=8.2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01305 FLSLIPHAINAVSAIAKHFG 20 "Phylloseptin-7 (PS-7; Frogs, amphibians, animals)" "P84572, Q0VZ42" Not found psn7 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-negative bacteria E. coli and P. aeruginosa, and the Gram-positive bacteria: S. aureus. No hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.16963159]Gram-negative bacteria: Escherichia coli (MIC=6 ?M), Pseudomonas aeruginosa (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M)" [Ref:16963159]Non-hemolytic activity at 6 M against human erythrocytes Linear Free Amidation Free L [Ref.16713656]No cytotoxicity information found Not found 16963159##16713656 Peptides. 2006 Dec;27(12):3092-3999.##Peptides. 2006 Sep;27(9):2129-2136. "Concei???o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC.##Chen T, Zhou M, Gagliardo R, Walker B, Shaw C." "Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis.##Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis." DRAMP01306 FLSLIPHAINAVSAIAKHF 19 "Phylloseptin-7 (PS-7; Frogs, amphibians, animals)" P85882 Not found Not found Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity but does not inhibit the growth of the fungus C. albicans. Tissue specificity: Expressed by the skin glands. PTM: Phenylalanine amide at F19." "Gram-negative bacterium: Escherichia coli ATCC 11775 (MIC=7.2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (MIC=3.6 ?M), Micrococcus luteus ATCC 49732 (MIC=1.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16963159]No cytotoxicity information found##[Ref.17553595]No cytotoxicity information found Not found 17553595##16963159 Peptides. 2007 Jul;28(7):1331-1343.##Peptides. 2006 Dec;27(12):3092-3099. "Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.##Concei??o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC." A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.##Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis. DRAMP01319 RRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA 48 "Cathelicidin-AL (Gly-rich; Frogs, amphibians, animals)" No entry found Not found Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=6.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 ?g/ml), Bacillus subtilis (MIC=100 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 ?g/ml), Psecdomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Psecdomonas aeruginosa ATCC27853 (MIC=6.25 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22009138]No cytotoxic against HUVEC or RMMCs at the concentration of 0.4 mg/ml. Not found 22009138 Amino Acids. 2012 Aug;43(2):677-685. "Hao X, Yang H, Wei L, Yang S, Zhu W, Ma D, Yu H, Lai R." Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate. DRAMP01339 FLPIVGKLLSGLSGLL 16 "Amolopin-2a (Frogs, amphibians, animals)" No entry found Not found Not found Amolops loloensis (Rufous-spotted torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus (MIC=2.00 ?g/ml), Bacillus dysenteriae (MIC=1.50 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=3.00 ?g/ml).##Candida albicans (MIC=6.50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17000029]Display cytotoxicity against HepG2(IC50=77 mg/ml). Not found 17000029 Peptides. 2006 Dec;27(12):3085-3091. "Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R." "Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis." DRAMP01341 FLPLAVSLAANFLPKLFCKITKKC 24 "Amolopin-1b (Frogs, amphibians, animals)" A0SN42 Not found Not found Amolops loloensis (Rufous-spotted torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus (MIC=5.50 ?g/ml), Bacillus dysenteriae (MIC=2.20 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=6.50 ?g/ml).##Yeast: Candida albicans (MIC=7.50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys18 and Cys24) Disulfide bridge between Cys18 and Cys24. L [Ref.17000029]Display cytotoxicity against HepG2(IC50=58 mg/ml). Not found 17000029 Peptides. 2006 Dec;27(12):3085-3091. "Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R." "Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis." DRAMP01346 VIGSILGALASGLPTLISWIKNR 23 "Prepromelittin-related peptide (Frogs, amphibians, animals)" A7BJK5 Not found prMRP Rana sakuraii (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).##Yeast: Candida albicans (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17174009]No cytotoxicity information found##[Ref.17826868]No cytotoxicity information found Not found 17174009##17826868 Peptides. 2007;28(3):505-514.##Peptides. 2007 Oct;28(10):2061-2068. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Suzuki H, Conlon JM, Iwamuro S." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.##Evidence that the genes encoding the melittin-related peptides in the skins of the Japanese frogs Rana sakuraii and Rana tagoi are not orthologous to bee venom melittin genes: developmental- and tissue-dependent gene expression. DRAMP01347 AIGSILGALAKGLPTLISWIKNR 23 "Prepromelittin-related peptide (Frogs, amphibians, animals)" A7BJK6 Not found prMRP Rana tagoi (Tago frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix Not found 6dst resolved by NMR (related PDB_ID) Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Antifungal activity against C. albicans. "[Ref.12804591]Gram-positive bacterium: Staphylococcus aureus (MIC=3.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=20 ?M).##Yeast: Candida albicans (MIC=19 ?M).##EL4 T-lymphoma cells (MIC=14 ?M).##[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=6.25 M), Staphylococcus epidermidis (MIC=3.13 M), Bacillus subtilis (MIC=3.13 M);##Gram-negative bacteria : Escherichia coli (MIC=25 M), Pseudomonas aeruginosa (MIC=12.5 M), Klebsiella pneumoniae (MIC=12.5 M)" [Ref.27271216] 100% hemolysis at 20 M against human red blood cells Linear Free Amidation Free L [Ref.12804591]Display cytotoxic against L929 fibroblasts(LC50=20 M);EL4 T-lymphoma cells(LC50=14 M).##[Ref.27271216]L929 cells:Cell viability is approximately 10% at the concentration of 6.25?M. Not found 12804591##17174009##27271216 Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.##Peptides. 2007;28(3):505-514.##Sci Rep. 2016 Jun 8;6:27394. "Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pl T##Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji" "A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties##Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii##Design of an -helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity" DRAMP01350 FCTMIPIPRCY 11 "Tigerinin-1 (Frogs, amphibians, animals)" P82651 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=30 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=30 ?g/ml), Micrococcus luteus MT 166 (MIC=20 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=40 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=40 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=80 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys2 and Cys10. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01351 RVCFAIPLPICH 12 "Tigerinin-2 (Frogs, amphibians, animals)" P82652 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=20 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=40 ?g/ml), Micrococcus luteus MT 166 (MIC=20 ?g/ml).##Gram-negative bacteria: Pseudomonas putida NCIM 2102 (MIC=50 ?g/ml), Escherichia coli (MIC=50 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01352 RVCYAIPLPICY 12 "Tigerinin-3 (Frogs, amphibians, animals)" P82653 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=30 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=30 ?g/ml), Micrococcus luteus MT 166 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=40 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=40 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=80 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01353 RVCYAIPLPIC 11 "Tigerinin-4 (Frogs, amphibians, animals)" P82654 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand-turn Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacterium: Staphylococcus aureus ATCC 8530 (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=60 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=60 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation;Cyclization (Cys3 and Cys11) Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01355 FLGGLIKIVPAMICAVTKKC 20 "Ranalexin (Frogs, amphibians, animals)" P39084 Not found Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations. Tissue specificity: Expressed by the skin dorsal glands. Developmental stage: Expression starts at metamorphosis and continues into adulthood. PTM: Contains one disulfide bond 14-20." "Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=32 ?g/ml), Pseudomonas aeruginosa (MIC=128 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 8144672##9578480 J Biol Chem. 1994 Apr 8;269(14):10849-10855.##Eur J Biochem. 1998 Apr 1;253(1):221-228. "Clark DP, Durell S, Maloy WL, Zasloff M.##Vignal E, Chavanieu A, Roch P, Chiche L, Grassy G, Calas B, Aumelas A." "Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.##Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles." DRAMP03024 LKLKSIVSWAKKVL 14 "Mastoparan B (MP-B; insects, arthropods, invertebrates, animals)" P21654 Not found Not found Vespa basalis (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti Mammalian cells, Anti-cancer" Not found Alpha helix Tryptophan residue in MP None Function: Mast cell degranulating peptide. Activates G proteins that couple to phospholipase C. Has hemolytic activity. "[Ref.10667861] Gram-positive bacteria: Staphylococcus epidermidis ATTC 12228 (MIC=25 ?M), Bacillus subtilis PCI 219 (MIC=25 ?M), Enterococcus faecium EFMY-28 (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli NIHJ JC-2 (MIC=50 ?M)" "[Ref.10667861] 68.2% hemolysis at the peptide concentration of 100 ?M is , 27.9% Hemolysis at 50 ?M against human red blood cells." Linear Free Amidation Free L [Ref.10667861]No cytotoxicity information found##[Ref.8555423]No cytotoxicity information found Not found 10667861##8555423 J Pept Res. 2000 Jan;55(1):51-62.##Biopolymers. 1995 Dec;36(6):793-801 "Yu K, Kang S, Park N, Shin J, Kim Y.##Park NG, Yamato Y, Lee S, Sugihara G1995" Relationship between the tertiary structures of mastoparan B and its analogs and their lytic activities studied by NMR spectroscopy.##Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity DRAMP01358 FLGGLFKLVPSVICAVTKKC 20 "Ranalexin-Vb (Frogs, amphibians, animals)" No entry found Not found Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 15996769 Regul Pept 2005; 131: 38-45. Conlon JM et al Bevier CR. "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP01359 FLGGLMKIIPAAFCAVTKKC 20 "Ranalexin-1G (Frogs, amphibians, animals)" No entry found Not found Not found Rana grylio (North American pig frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None "Function: Has growth-inhibitory activity against the gram-positive bacterium Staphylococcus aureus, the gram-negative bacterium Escherichia coli and the yeast, Candida albicans." Gram-negative bacterium: Escherichia coli (MIC=9 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=18 ?M).##Yeast: Candida albicans (MIC=70 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 10828493 Regul Pept. 2000 Jun 30;90(1-3):53-60. "Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM." Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio. DRAMP01362 GLMSVLGHAVGNVLGGLFKS 20 "Frenatin-3 (Frogs, amphibians, animals)" P56249 Not found Not found Litoria infrafrenata (Giant tree frog) (White-lipped tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Wide spectrum antimicrobial peptide. Considered to interact with the outer lipid layer of the bacterial cell, penetrate the bacterial membrane, form ion channels, and ultimately kill the cell. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." "Gram-negative bacterium: Escherichia coli (MIC=50 ?g/ml);##Gram-positive bacteria: Leuconostoc mesenteroides (MIC=25 ?g/ml), Bacillus cereus (MIC=12.5 ?g/ml), Micrococcus luteus (MIC=1.5 ?g/ml), Pastewella haemolytica (MIC=0.8 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.9225251]No cytotoxicity information found Not found 9225251 J Pept Sci. 1996 Mar-Apr;2(2):117-124. "Raftery MJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata. DRAMP01364 GLFGVLAKVAAHVVPAIAEHF 21 "Maculatin-1.1 (Frogs, amphibians, animals)" P82066 Not found Not found Litoria genimaculata (Green-eyed tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Alpha helix Not found None "Function: Maculatin-1.1 shows significant antibacterial activity against Gram-positive bacteria, less against Gram-negative bacteria. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Bacillus cereus (MIC=3 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=3 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=11.3 M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Not found 16140737##9620615##15203252 J Virol. 2005 Sep;79(18):11598-606. ##J Pept Sci. 1998 Apr;4(2):111-115.##Peptides. 2004; 25: 1035-1054. "VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. ##Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01370 MLCKLSMFGAVLGVPACAIDCLPMGKTGGSCEGGVCGCRKLTFKILWDKKFG 52 "Oh-defensin (O. hainana defensin; spiders, animals)" No entry found Not found Not found Ornithoctonus hainana (Venoms) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial and antifungal activities. "Gram-positive bacteria: Staphylococcus aureus (MIC=1.25 ?g/ml), Bacillus cereus (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=1.25 ?g/ml), Bacillus dysenteriae (MIC=1.25 ?g/ml), Pseudomonas aeruginosa (MIC=5 ?g/ml).##Yeast: Candida albicans (MIC=1.25 ?g/ml)." "[Ref.21538709] It has little hemolytic activity, inducing 7% hemolysis at the concentration up to 200 ?g/ml (about 36 ?M)." Cyclic Free Free Has three disulfide bonds L No cytotoxicity information found Not found 21538709 J Pept Sci. 2011 Jul;17(7):540-544. "Zhao H, Kong Y, Wang H, Yan T, Feng F, Bian J, Yang Y, Yu H." "A defensin-like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana." DRAMP01371 GLLSGILGAGKHIVCGLTGCAKA 23 "Odorranain-NR (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Combine helix and strand structure "Odorranain-NR has a large proportion of beta-sheet. In Tris HCl + SDS, odorranain-NR has a major conformation of beta-sheet (79.2%) and a minor conformation of beta-turn (1.3%). In Tris HCl, the beta-sheet has been decreased to 57.1% and the beta-turn has been increased to 10.5%. The beta-sheet has been decreased to 39.8% in water." None "Function: Odorranain-NR exhibits antimicrobial activity against the tested strains except E. coli ATCC25922. Odorranain-NR has little hemolytic activity on red blood cells even with peptide concentration up to 100 mg/ml. PTM: Odorranain-NR has an intramolecular disulfide-bridged hexapeptide segment, which is a new type of disulfide-bridge motif in amphibian antimicrobial peptides." "[Ref.18282640]Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=9.375 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 ?g/ml), Bacillus dysenteriae (MIC=37.5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=18.75 ?g/ml)." [Ref:18282640] It has little hemolytic activity at 100 g/ml against rabbit red blood cells Cyclic Free Free Disulfide bond between Cys15 and Cys20. L No cytotoxicity information found Not found 18282640 Peptides. 2008 Apr;29(4):529-535. Che Q et al Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami. DRAMP00931 TCSYTMEA 8 Antimicrobial peptide 3 (Cn-AMP3; Plant defensin) P86707 Not found Not found Cocos nucifera (Coconut palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level). Subunit structure: Monomer." [Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=257 g/ml) and Staphylococcus aureus (MIC=274 g/ml);##Gram-negative bacteria: Escherichia coli (MIC=302 g/ml) and Pseudomonas aeruginosa (MIC=259 g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19111587]No cytotoxicity information found Not found 19111587 Peptides. 2009 Apr;30(4):633-637. "Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL." Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water. DRAMP00930 TESYFVFSVGM 11 Antimicrobial peptide 2 (Cn-AMP2; Plant defensin) P86706 Not found Not found Cocos nucifera (Coconut palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level). Subunit structure: Monomer." "[Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=150 g/ml), Staphylococcus aureus (MIC=170 g/ml);##Gram-negative bacteria: Escherichia coli (MIC=170 g/ml), Pseudomonas aeruginosa (MIC=169 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19111587]No cytotoxicity information found Not found 19111587 Peptides. 2009 Apr;30(4):633-637. "Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL." Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water. DRAMP00929 SVAGRAQGM 9 Antimicrobial peptide 1 (Cn-AMP1; Plant defensin) P86705 Not found Not found Cocos nucifera (Coconut palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Helix Not found 2N0V resolved by NMR. "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level). Subunit structure: Monomer." "[Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=76 g/ml), Staphylococcus aureus (MIC=80 g/ml);##Gram-negative bacteria: Escherichia coli (MIC=82 g/ml), Pseudomonas aeruginosa (MIC=79 g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19111587]No cytotoxicity information found Not found 19111587 Peptides. 2009 Apr;30(4):633-637. "Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL." Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water. DRAMP03542 HKTDSFVGLM 10 "Neurokinin A (NKA; chicken, animals)" P19851 Belongs to the tachykinin family. Not found Gallus gallus (Chicken) "Antimicrobial, Antibacterial, Neuropeptide, Anti-Gram+, Anti-Gram-" Protein level Not found Not found 1N6T resolved by NMR. "Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Antibacterial activity is very low. PTM: Methionine amide at position 10." "[Ref.18603306] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>500 g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>500 g/ml) ;## Gram-positive bacteria: Streptococcus mutans NCTC 10449 (MIC> 500 g/ml), Lactobacillus acidophilus NCTC 1723 (MIC>500 g/ml), Enterococcus faecalis NCTC 12697 (MIC>500 g/ml), Staphylococcus aureus ATCC 25923 (MIC>500 g/ml);## Yeast: Candida albicans NCTC 3179 (MIC>500 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.18603306]No cytotoxicity information found Not found 18603306 J Neuroimmunol. 2008 Aug 30;200(1-2):11-16. "El Karim IA, Linden GJ, Orr DF, Lundy FT." "Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites." DRAMP02344 KVHGSLARAGK 11 "40S ribosomal protein S30 (Fish, chordates, animals)" P83328 Belongs to the eukaryotic ribosomal protein eS30 family. fau Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and low activity against Gram-negative bacteria. "[Ref.12147245] Gram-negetive bacteria: Escherichia coli (EC50>0.3 M, MBC>0.3 M), Listonella anguillarum (EC50>0.3 M, MBC>0.3 M) ;##Gram-positive bacteria: Bacillus subtilis (EC50=0.15C0.3 M, MBC>0.3 M), Planococcus citreus (EC50=0.02C0.04 M, MBC=0.08 M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.12147245]No cytotoxicity information found Not found 12147245 Biochem Biophys Res Commun. 2002 Aug 9;296(1):167-171. "Fernandes JM, Smith VJ." A novel antimicrobial function for a ribosomal peptide from rainbow trout skin. DRAMP02993 YVPLPNVPQPGRRPFPTFPGQGPFNPKIKWPQGY 34 "Abaecin (Pro-rich; insects, arthropods, invertebrates, animals)" P15450? Not found Not found Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Rich The prolines are in repeated motifs. None Function: This peptide has bactericidal activity. "[Ref.2298215] Gram-negative bacteria: Agrobacterium tumefaciens Gembloux A (MIC=25-50 ?g/ml), Erwinia salicis NCPPB 2530 (MIC=25-50 ?g/ml), Escherichia coli NCTC 9001 (MIC=25-50 ?g/ml), Escherichia coli K514 (MIC=10-25 ?g/ml), Pseudomonas syringae pv.tomato NCPPB 1105 (MIC=25-50 ?g/ml), Xanthomonas campestris pv. vesicatoria LMG 905 (MIC=5-10 ?g/ml);##Gram-positive bacteria: Bacillus megateriurn QMB 1551 (MIC=10-25 ?g/ml), Micrococcus lysodeikticus LMG 4050 (MIC=10-25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.2298215]No cytotoxicity information found##[Ref.7961803]No cytotoxicity information found Not found 2298215##7961803 Eur J Biochem. 1990 Jan 26;187(2):381-386.##J Biol Chem. 1994 Nov 18;269(46):28569-28575. "Casteels P, Ampe C, Riviere L, Van Damme J, Elicone C, Fleming M, Jacobs F, Tempst P.##Casteels-Josson K, Zhang W, Capaci T, Casteels P, Tempst P." "Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera).##Acute Transcriptional Response of the Honeybee Peptide-Antibiotics Gene Repertoire and Required Post-translational Conversion of the Precursor Structures." DRAMP02997 GNNRPVYIPQPRPPHPRL 18 "Apidaecin-1B (Apidaecin IB; Insects, animals)" "P35581, Q06602, Q06601, Q8WSY8" Belongs to the apidaecin family Not found Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found 4E81 resolved by X-ray. Function: Apidaecins have bactericidal activity; predominantly against Gram-negative bacteria. They seem to interfere with cell propagation. "[Ref.2676519] Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 g/ml), Erwinia salicis (MIC=0.02 g/ml), Escherichia coli (MIC=0.1 g/ml), Pseudomonas syringae (MIC=0.1 g/ml), Rhizobium meliloti (MIC=0.02 g/ml), Salmonella Newport (MIC=0.2 g/ml), Salmonella typhimurium (MIC=0.1 g/ml), Shigella flexneri (MIC=0.1 g/ml);##Gram-positive bacteria: Corynebacterium insidiosum (MIC=50 g/ml), Bacillus megaterium (MIC=100 g/ml).##[Ref.2298215] Gram-negative bacteria: Agrobacterium tumefaciens Gembloux A (MIC1 ?g/ml), Erwinia salicis NCPPB 2530 (MIC1 ?g/ml), Escherichia coli NCTC 9001 (MIC1 ?g/ml), Escherichia coli K514 (MIC=25-50 ?g/ml), Pseudomonas syringae pv.tomato NCPPB 1105 (MIC1 ?g/ml), Xanthomonas campestris pv. vesicatoria LMG 905 (MIC100 ?g/ml);##Gram-positive bacteria: Bacillus megateriurn QMB 1551 (MIC=25-50 ?g/ml), Bacillus alvei LMG 6922 (MIC=50-100 ?g/ml),Micrococcus lysodeikticus LMG 4050 (MIC=25-50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.2298215]No cytotoxicity information found##[Ref.2676519]No cytotoxicity information found Not found 2676519##2298215 EMBO J. 1989 Aug;8(8):2387-2391.##Eur J Biochem. 1990 Jan 26;187(2):381-386. "Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P.##Casteels P, Ampe C, Riviere L, Van Damme J, Elicone C, Fleming M, Jacobs F, Tempst P." "Apidaecins: antibacterial peptides from honeybees.##Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera)." DRAMP02840 FKCRRWQWRMKKLGAPSITCVRRAF 25 "Lactoferricin B (Lfcin B; mammals, animals)" "P24627, E6YCQ7, B3VTM3, B9VPZ5, C7FE01, Q6LBN7, Q19KS1" Belongs to the transferrin family LTF Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Beta strand (4 strands; 8 residues) "Residues 7-9 form beta1 and residues 17-19 form beta2 (in membrane). This contrasts with X-ray structure where residues 1-13 is helical. Thus, this peptide appears to be able to adopt a different conformation depending on environmental conditions. disulfide bond is not required for the antimicrobial potency." 1LFC resolved by NMR. "Function: Lactoferricin B function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. Activity regulation: Inhibited by PMSF and Pefabloc. PTM: Contains one disulfide bond 3-20" "[Ref.8980754] Gram-negative bacteria: Escherichia coli L361 (MIC=4 ?M or 12.5 ?g/ml), Salmonella Salford (MIC=4 ?M or 12.5 ?g/ml), Escherichia coli O:9 (MIC=6 ?M or 18.8 ?g/ml), Pseudomonas ?uorescens (MIC=10 ?M or 31.3 ?g/ml) ;##Gram-positive bacteria: Listeria monocytogenes (MIC=2 ?M or 6.3 ?g/ml), Staphylococcus aureus (MIC=6 ?M or 18.8 ?g/ml), Bacillus cereus (MIC=6 ?M or 18.8 ?g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys3 and Cys20. L No cytotoxicity information found Not found 8980754##9521752##1490908 "Antimicrob Agents Chemother. 1997 Jan;41(1):54-59. ##Biochemistry. 1998 Mar 24;37(12):4288-4298.## J Appl Bacteriol. 1992 Dec;73(6):472-9." "Hoek KS, Milne JM, Grieve PA, Dionysius DA, Smith R. ##Hwang PM, Zhou N, Shan X, Arrowsmith CH, Vogel HJ. ##Bellamy W, Takase M, Wakabayashi H, Kawase K, Tomita M.1992" "Antibacterial activity in bovine lactoferrin-derived peptides. ##Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. ## Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. " DRAMP02244 GLFLDTLKGAAKDVAGKLLEGLKCKIAGCKP 31 "Ranatuerin-2Ca (Ranatuerin 2Ca; Frogs, amphibians, animals)" P82878 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide has defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, male-specific defense response to bacterium, antibacterial humoral response, antibacterial humoral response, induced systemic resistance, antifungal innate immune response, antifungal humoral response, defense response to fungus (incompatible interaction) in GO analysis. Tissue specificity: Expressed by the skin glands. PTM: Disulfide bond at position 24 and 29." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys24 and Cys29. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP01357 FLGGLMKAFPAIICAVTKKC 20 "Ranalexin-1Cb (Ranatuerin 1Cb; Frogs, amphibians, animals)" P82877 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide has defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, male-specific defense response to bacterium, antibacterial humoral response, antibacterial humoral response, induced systemic resistance, antifungal innate immune response, antifungal humoral response, defense response to fungus (incompatible interaction) in GO analysis. Tissue specificity: Expressed by the skin glands." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP02246 SMLSVLKNLGKVGLGLVACKINKQC 25 "Ranatuerin-1C (Ranatuerin 1C; Frogs, amphibians, animals)" P82875 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10822101] Gram-positive bacterium: Staphylococcus aureus (MIC=55 M);##Gram-negative bacterium: Escherichia coli (MIC=1.5 M).##Yeast: Candida albicans (MIC=58 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys19 and Cys25) Disulfide bond between Cys19 and Cys25. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP01394 GLLRASSVWGRKYYVDLAGCAKA 23 "Odorranain-W2 (Frogs, amphibians, animals)" A7YL71 Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Shows antibacterial and antifungal activities. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?g/ml), Bacillus dysenteriae (MIC=30 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=20 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17698252]No cytotoxicity information found Not found 17698252 Peptides. 2007 Aug;28(8):1527-1531. "Chen L, Li Y, Li J, Xu X, Lai R, Zou Q." An antimicrobial peptide with antimicrobial activity against Helicobacter pylori. DRAMP01395 VVKCSYRLGSPDSQCN 16 "Odorranain-A-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=35.2 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=17.6 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Free Disulfide bond between Cys4 and Cys15. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01396 GFMDTAKNVAKNMAGNLLDNLKCKITKAC 29 "Odorranain-F-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=2.5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=2.5 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01397 GFMDTAKNVAKNMAVTLLDNLKCKITKAC 29 "Odorranain-F-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.5 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.8 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01398 GFMDTAKNVAKNEAGNLLDNLKCKITKAC 29 "Odorranain-F-OA3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=6.3 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01399 GFMATAKNVAKNMDVTLLDNLKCKITKAC 29 "Odorranain-F-OA4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=4.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01401 GFMNTAKNVAKNVAVTLLDNLKCKITGGC 29 "Odorranain-F-OW1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=2 ?M), Pseudomonas aeruginosa (MIC=4 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01402 GLFTLIKGAYKLDAPTVACN 20 "Odorranain-J-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=20.1 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01403 GLFTLIKGAYKNDAPTVACN 20 "Odorranain-J-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=20.1 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01409 GILSGILGVGKKLVCGLSGLC 21 "Nigrocin-OR1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=4 ?M), Pseudomonas aeruginosa (MIC=7 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M).##Yeast: Candida albicans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01410 GILSGILGVGKMLVCGLSGLC 21 "Nigrocin-OR2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Bacillus pyocyaneus CMCCB 10104 (MIC=5 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01411 GILSGLLGVGKMLVCGLSGLC 21 "Nigrocin-OR3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Bacillus pyocyaneus CMCCB 10104 (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01412 GLLGSLFGAGKKVACALSGLC 21 "Nigrocin-2HSa (Frogs, amphibians, animals)" P0C8U0 Not found Not found Odorrana hosii (Hose's rock frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 15-21." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=56 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=28 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01413 GLLGSIFGAGKKIACALSGLC 21 "Nigrocin-2HSb (Frogs, amphibians, animals)" P0C8U1 Not found Not found Odorrana hosii (Hose's rock frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 15-21." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=28 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=14 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01414 GIFSTVFKAGKGIVCGLTGLC 21 "Nigrocin-2ISa (Frogs, amphibians, animals)" F1T156 Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L [Ref.21193000]No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01415 GILGTVFKAGKGIVCGLTGLC 21 "Nigrocin-2ISb (Frogs, amphibians, animals)" F1T157 Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01416 GILSTVFKAGKGIVCGLSGLC 21 "Nigrocin-2ISc (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 ?M).##Yeast: Candida albicans (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 21867685 Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-677. "Iwakoshi-Ukena E, Soga M, Okada G, Fujii T, Sumida M, Ukena K." Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning. DRAMP01417 GLLSGILGAGKHIVCGLSGLC 21 "Nigrocin-2GRa (Frogs, amphibians, animals)" No entry found Not found Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial against Gram-negative bacterium E. coli. Also has a weak hemolytic activity against human erythrocytes. [Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:16621155] LC50=295 M against human erythrocytes Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami." DRAMP01418 GLFGKILGVGKKVLCGLSGMC 21 "Nigrocin-2GRb (Frogs, amphibians, animals)" No entry found Not found Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against the Gram-negative bacterium E. coli and the Gram-positive bacterium S. aureus. Also has a weak hemolytic activity against human erythrocytes. [Ref.16621155]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Yeast: Candida albicans (MIC=50 ?M). [Ref:16621155] LC50=40 M against human erythrocytes Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami." DRAMP01419 GLLSGILGAGKNIVCGLSGLC 21 "Nigrocin-2GRc (Frogs, amphibians, animals)" No entry found Not found Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial against Gram-negative bacterium E. coli. Also has a weak hemolytic activity against human erythrocytes. [Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=50 ?M). [Ref:16621155] LC50>500 M against human erythrocytes Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami." DRAMP01420 GLLSGILGAGKHIICGLSGLC 21 "Nigrocin-OG4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC>100 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?g/ml), Bacillus subtilis (MIC>100 ?g/ml).##Yeast: Candida albicans (MIC=1.10 ?g/ml)." "[Ref.17272268] RCH=65.5 7.7% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01421 GLLSGILGAGKQKVCGLSGLC 21 "Nigrocin-OG5 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=9.37 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=18.75 ?g/ml), Bacillus subtilis (MIC=37.50 ?g/ml).##Yeast: Candida albicans (MIC=4.68 ?g/ml)." "[Ref.17272268] RCH=87.2 2.6% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01422 GLLSGVLGVGKKVLCGLSGLC 21 "Nigrosin-OG21 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=4.68 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml).##Yeast: Candida albicans (MIC=4.68 ?g/ml)." "[Ref.17272268] RCH=100% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01423 GLLSGILGAGKHIVCGLSGLR 21 "Nigrosin-OG13 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=4.68 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml).##Yeast: Candida albicans (MIC=1.10 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17272268]No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01426 GLLSGVLGVGKKIVCGLSGLC 21 "Nigrocin-1-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=5.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01427 GIFGKILGVGKKTLCELSGMC 21 "Nigrocin-1-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.3 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01428 GIFLKVLGVGKKVLCGVSGLC 21 "Nigrocin-1-OA3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=10.8 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01429 GLISGILGVGKKLVCGLSGLC 21 "Nigrocin-1-OR1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=11.5 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01430 GLISGILGVGKMLVCGLSGLC 21 "Nigrocin-1-OR2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=8.6 ?g/ml)" [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01431 GLISGLLGVGKMLVCGLSGLC 21 "Nigrocin-1-OR3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=10.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01432 GILGNIVGMGKKIVCGLSGLC 21 "Nigrocin-1-OW2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.2 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01433 GILGNIVGMGKKVVCGLSGLC 21 "Nigrocin-1-OW3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=6.7 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01434 GILSGVLGMGKKIVCGLRGLC 21 "Nigrocin-1-OW4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=14.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=7.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01435 GILGNIVGMGKQVVCGLSGLC 21 "Nigrocin-1-OW5 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=5.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01436 GILSGVLGMGKKIVCGLSGLC 21 "Nigrocin-1-OW1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=4.4 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01438 GIFGKILGAGKKVLCGLSGLC 21 "Nigrocin-2JDa (Frogs, amphibians, animals)" B3A0M6 Not found Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity against rabbit erythrocytes. PTM: contains one disulfide bond 15-21. " "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Staphylococcus aureus CIB 85462 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=16 ?M), Escherichia coli CIB 84492 (MIC=16 ?M);##Yeast: Candida albicans (MIC=63 ?M)." [Ref:22917879] It has 80.3 5.5% hemolytic activity at 128 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP01439 GIFGKILGVGKKVLCGLSGMC 21 "Nigrocin-2JDb (Odorranain-H2; Frogs, amphibians, animals)" B3A0M7 Not found Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity against rabbit erythrocytes. PTM: contains one disulfide bond 15-21. " "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15 ?M), Staphylococcus aureus CIB 85462 (MIC=15 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=8 ?M), Escherichia coli CIB 84492 (MIC=8 ?M);##Yeast: Candida albicans (MIC=31 ?M)." [Ref:22917879] It has 88.4 4.2% hemolytic activity at 128 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP01440 GILSGILGMGKKLVCGLSGLC 21 "Nigrocin-2LVb (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana livida (Chinese Odorrana frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 20158520 FEBS J. 2010 Mar;277(6):1519-1531. "Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C." Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis. DRAMP01441 SILSGNFGVGKKIVCGLSGLC 21 "Nigrocin-2VB (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana livida (Chinese Odorrana frogs) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 20158520 FEBS J. 2010 Mar;277(6):1519-1531. "Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C." Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis. DRAMP01442 GILSGILGAGKSLVCGLSGLC 21 "Nigrocin-2SCa (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana schmackeri (Chinese Odorrana frogs) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 20158520 FEBS J. 2010 Mar;277(6):1519-1531. "Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C." Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis. DRAMP01443 GILSNVLGMGKKIVCGLSGLC 21 "Nigrocin-2SCc (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana schmackeri (Chinese Odorrana frogs) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=70 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 20158520 FEBS J. 2010 Mar;277(6):1519-1531. "Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C." Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis. DRAMP01447 GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC 37 "Esculentin-2CHa (Frogs, amphibians, animals)" No entry found Not found Not found Lithobates chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: E. coli (MIC=5 ?M), K. pneumoniae (MIC=5 ?M), P. aeruginosa (MIC=5 ?M);##Gram-positive bacterium: S. aureus (MIC=5 ?M).##Yeast: C. albicans (MIC=10 ?M)." [Ref.21262304] LC50=150 ?M against human erythrocytes Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 21262304 Peptides. 2011 Apr;32(4):664-669. "Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01452 RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC 47 "Esculentin-1LTa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=0.6 ?M), Bacillus licheniformis X39 (MIC=10 ?M), Staphylococcus carnosus KHS (MIC=1.3 ?M), Rhodococcus rhodochrous X15 (MIC=0.3 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?M), Serratia rubidaea X01 (MIC=10 ?M), Psychrobacter faecalis X29 (MIC=0.6 ?M).##Yeast: Candida albicans ATCC2002 (MIC=80 ?M)." [Ref.22426384] LD50>480 M against human erythrocytes Cyclic Free Cyclization (Cys41 and Cys47) Disulfide bond between Cys41 and Cys47. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01453 GIFSLFKAGAKFFGKHLLKQAGKAGAEHLACKATNQC 37 "Esculentin-2LTa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.6 ?M), Bacillus licheniformis X39 (MIC=3.2 ?M), Staphylococcus carnosus KHS (MIC=3.2 ?M), Rhodococcus rhodochrous X15 (MIC=0.8 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=1.6 ?M). " [Ref.22426384] LD50>600 M against human erythrocytes Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01454 GLFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC 37 "Esculentin-2JDa (Frogs, amphibians, animals)" B3A0M8 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against E. coli and S. aureus strains (Probable). Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 31-37." "Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=34 ?g/ml), Extended-spectrum ??-lactamases E. coli (ESBL) (MIC=34 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (ATCC 25923) (MIC=8 ?g/ml), Methicillin-resistant S. aureus (MRSA) (MIC=8 ?g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: de novo sequencing and analysis of tandem mass spectrometry data." DRAMP01456 GLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC 37 "Esculentin-2PLa (Frogs, amphibians, animals)" "A7WNV5, D3UA57" Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against the Gram-negative bacterium E. coli, the Gram-positive bacterium: S. aureus and the yeast C. albicans. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 31-37." Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=10 ?M).##Yeast: Candida albicans (MIC=49 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01457 GIFSKFAGKGIKDLIIKGVKGIAKEAGMDVIRTGIDIAGCKIKGEC 46 "Esculentin-1V (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Chinese frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=4.9 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 16427248 Genomics. 2006 May;87(5):638-644. "Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C." Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs. DRAMP01458 GIFTLFKGAAKLLGKTLAKEAGKTGLELMACKVTNQC 37 "Esculentin-2V (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Chinese frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=4.4 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 16427248 Genomics. 2006 May;87(5):638-644. "Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C." Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs. DRAMP01461 GLFSKFAGKGIKNMIIKGIKGIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1S (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana schmackeri (piebald odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.7 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 16427248 Genomics. 2006 May;87(5):638-644. "Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C." Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs. DRAMP01462 GLFTLIKGAVKMIGKTVAKEAGKTGLELMACKVTNQC 37 "Esculentin-2S (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana schmackeri (piebald odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=2.6 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.1 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 16427248 Genomics. 2006 May;87(5):638-644. "Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C." Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs. DRAMP01469 GIFALIKTAAKFVGKNLLKQAGKAGLEHLACKANNQC 37 "Esculentin-2-Ala (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Esculentin-2-Ala exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus dysenteriae (MIC=7.5 ?g/mL), Bacillus cereus (MIC=7.5 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=12.5 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Acinetobacter calcoaceticus (MIC=25 ?g/mL), Psecdomonas aeruginosa (MIC=50 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)" [Ref:19843479] It has 22% hemolytic activity at 100 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloen." DRAMP01470 GIFSLIKTAAKFVGKNLLKQAGKAGVEHLACKANNQC 37 "Esculentin-2-ALb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Esculentin-2-Alb exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=7.5 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=12.5 ?g/mL), Bacillus dysenteriae (MIC=7.5 ?g/mL), Acinetobacter calcoaceticus (MIC=12.5 ?g/mL), Psecdomonas aeruginosa (MIC=50 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)." [Ref:19843479] It has 17% hemolytic activity at 100 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloen." DRAMP01471 GLFPKINKKKAKTGVFNIIKTVGKEAGMDLIRTGIDTIGCKIKGEC 46 "Esculentin-1PLa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North American pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01472 GIFTKINKKKAKTGVFNIIKTIGKEAGMDVIRAGIDTISCKIKGEC 46 "Esculentin-1PLb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North American pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01474 GIFSKINKKKAKTGLFNIIKTVGKEAGMDVIRAGIDTISCKIKGEC 46 "Esculentin-1ARa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana areolata (crawfish frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Esculentin-1ARa has antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Also exhibits hemolytic activity against human erythrocytes (HC50=180 ?M). [Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=13 ?M). [Ref:12429503] HC50=180 ?M against human erythrocytes Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 12429503 Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. "Ali MF, Lips KR, Knoop FC, Fritzsch B, Miller C, Conlon JM." "Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata." DRAMP01475 GLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC 46 "Esculentin-1ARb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana areolata (crawfish frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Esculentin-1ARb has antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Also exhibits hemolytic activity against human erythrocytes (HC50=120 ?M). [Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M). [Ref:12429503] HC50=120 ?M against human erythrocytes Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 12429503 Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. "Ali MF, Lips KR, Knoop FC, Fritzsch B, Miller C, Conlon JM." "Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata." DRAMP01476 GIFSLIKGAAQLIGKTVAKEAGKTGLELMACKVTKQC 37 "Esculentin-2HSa (Frogs, amphibians, animals)" P0C8T9 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hosii (Hose's rock frog) (Rana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 31-37." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=32 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01477 GIFSKFGGKAIKNLFIKGAKNIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1HSa (Frogs, amphibians, animals)" P0C8T8 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana hosii (Hose's rock frog) (Odorrana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 40-46." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01479 GLFSKLNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC 46 "Esculentin-1CPa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates capito (North American New World frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. [Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Yeast: Candida albicans (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 19635516 Peptides. 2009 Oct;30(10):1775-1781. "Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). DRAMP01480 GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC 37 "Esculentin-2CPa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates capito (North American New World frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. [Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Yeast: Candida albicans (MIC=25 ?M) No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 19635516 Peptides. 2009 Oct;30(10):1775-1781. "Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). DRAMP01482 GIFSKFAGKGIKNLLVKGVKNIGKEVGMDVIRTGIDIAGCKIKGEC 46 "Esculentin-1ISa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Japanese Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial activity. "Gram-negative bacterium: Escherichia coli (MC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=25 ?M), Bacillus subtilis (MIC=25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01483 RIFSKIGGKAIKNLILKGIKNIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1ISb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Japanese Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity. "Gram-negative bacterium: Escherichia coli (MC=3.1 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01484 GIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC 37 "Esculentin-2ISa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Japanese Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity. "Gram-negative bacterium: Escherichia coli (MC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=25 ?M), Bacillus subtilis (MIC=6.3 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01486 GLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1GRa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grahami (Odorrana andersonii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Shows antibacterial activity, also activity against fungus C. albicans." Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M).##Yeast: Candida albicans (MIC>50 ?M). [Ref.16621155] LC50=210 M against human erythrocytes. Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 16621155 Peptides 2006; 27: 2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami." DRAMP01490 GILSLVKGVAKLAGKGLAKEGGKFGLELIACKIAKQC 37 "Esculentin-2A (Frogs, amphibians, animals)" P40845 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (European Edible frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species. "[Ref.8163497]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=0.8 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.4 ?M), Pseudomonas aeruginosa ATCC15692 (MIC=3.5 ?M)." [Ref:8163497] Not found in the literature Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 8163497 J Biol Chem. 1994 Apr 22;269(16):11956-11961. "Simmaco M, Mignogna G, Barra D, Bossa F." Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. DRAMP01491 GIFSKLAGKKLKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC 46 "Esculentin-1B (Frogs, amphibians, animals)" P40844 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (European Edible frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli D21 (MIC=0.2 ?M), Pseudomonas aeruginosa ATCC15692 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.1 ?M), Staphylococcus aureus cowan I (MIC=0.4 ?M).##Fungi: Candida albicans (MIC=0.5 ?M), Saccharomyces cerevisiae (MIC=0.9 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.8163497]No cytotoxicity information found Not found 8163497 J Biol Chem. 1994 Apr 22;269(16):11956-11961. "Simmaco M, Mignogna G, Barra D, Bossa F." Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. DRAMP01493 GLFSKFVGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=1.2 ?g/mL), Staphylococcus aureus ATCC 25923 (MIC=1.2 ?g/mL).##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.4 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01494 GLFSKFSGKGIKNFLIKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1-OA2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 ?g/mL);##Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=2.5 ?g/mL), Staphylococcus aureus ATCC 25923 (MIC=1.3 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.3 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01495 GLFSKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.4 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.4 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.7 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01496 GLFTKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2.8 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.8 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=5.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01497 GLFSKFAGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.4 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1.7 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.4 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.7 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01499 GIFSKISGKAIKNLFIKGAKNVGKEVGMDVVRTGIDVVGCKIKGEC 46 "Esculentin-1-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.4 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01501 GIFSKISGKAIKNLFIKGAKNVGKRVGMDVVRTGMDVVGCKIKGEC 46 "Esculentin-1-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.5 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=11 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=11 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01502 GIFSKISGKAIKNLFIKGAENVGKHVGIDVVRTGIDVVGCKIKGEC 46 "Esculentin-1-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01503 GIFSKISGKAIKNLFIKGAKNVGKEVGIDVVRTGMDVVGCKIKGEC 46 "Esculentin-1-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=4.1 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.1 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01504 GIFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC 37 "Esculentin-2-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.5 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.3 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=4.3 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.5 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01505 GLFTLIKGAAKLIGKTTAKEAGKTGKLEMACKITNQC 37 "Esculentin-2-OA2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01507 GVFTLIKGATQLIGKTLGKELGKTGLELMACKITNQC 37 "Esculentin-2-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=10.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01508 GVFTLIKGATQLIGKTLGKEVGKTGLELMACKITKQC 37 "Esculentin-2-OR2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.1 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=16.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.1 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01509 GVFTLLKGATQLIGKTLGKELGKTGLELMACKITNQC 37 "Esculentin-2-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=7.9 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.9 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=15.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01510 GVFTLIKGATQLIGKTLGKELGKTGLELMACKITEQC 37 "Esculentin-2-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=3.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01511 GVFTLIKGATQLIGKTLGKELGKTGLEIMACKITKQC 37 "Esculentin-2-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=15.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15.8 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=7.9 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01513 GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC 46 "Esculentin-1 (Frogs, amphibians, animals)" P32414 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.2 ?M), Pseudomonas aeruginosaATCC15692 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.1 ?M), Staphylococcus aureus Cowan1 (MIC=0.4 ?M).##Fungi: Candida albicans (MIC=0.5 ?M), Saccharomyces cerevisiae (MIC=0.9 ?M)." [Ref. 8163497] LC>100M Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.8508915]No cytotoxicity information found Not found 8508915 FEBS Lett. 1993 Jun 14;324(2):159-161. "Simmaco M, Mignogna G, Barra D, Bossa F." Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. DRAMP01520 GLLNTFKDWAISIAKGAGKGVLTTLSCKLDKSC 33 "Rugosin-A (Frogs, amphibians, animals)" P80954 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Glandirana rugosa (Japanese wrinkled frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." "Gram-positive bacteria: Staphylococcus aureus 209P (MIC=6.25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=12.5 ?g/ml), Micrococcus luteus ATCC9341 (MIC=25 ?g/ml), Streptococcus pyogenes COOK (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli NIHJ (MIC=100 ?g/ml), Pseudomonas aeruginosa PAO-1 (MIC>100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L [Ref.7612013]No cytotoxicity information found Not found 7612013 Biochem Biophys Res Commun. 1995 Jul 6;212(1):249-254. "Suzuki S, Ohe Y, Kagegawa T, Tatemoto K." "Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa." DRAMP01521 SLFSLIKAGAKFLGKNLLKQGAQYAACKVSKEC 33 "Rugosin-B (Frogs, amphibians, animals)" P80955 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-negative and Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." "Gram-positive bacteria: Staphylococcus aureus 209P (MIC=6.25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=6.25 ?g/ml), Micrococcus luteus ATCC9341 (MIC=1.56 ?g/ml), Streptococcus pyogenes COOK (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli NIHJ (MIC=12.5 ?g/ml), Pseudomonas aeruginosa PAO-1 (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L [Ref.7612013]No cytotoxicity information found Not found 7612013 Biochem Biophys Res Commun. 1995 Jul 6;212(1):249-254. "Suzuki S, Ohe Y, Kagegawa T, Tatemoto K." "Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa." DRAMP01524 SIRDKIKTIAIDLAKSAGTGVLKTLICKLDKSC 33 "Rugosin-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has weak hemolytic activity gainst rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.69 ?g/ml), Bacillus subtilis (MIC=9.38 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=5.63 ?g/ml)" [Ref:19778602]Show weak hemolytic activity against rabbit red cells Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01525 SIRDKIKTIAIDLAKSAGMGILKTLICKLDKSC 33 "Rugosin-RN3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=16.51 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=15.00 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01526 SIRDKIKTIAIDLAKSAGTGVLKTLICKLNKSC 33 "Rugosin-RN5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=15.00 ?g/ml), Staphylococcus aureus ATCC43300 (MRSA) (MIC=12.50 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=18.75 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01533 CVISAGWNHKIRCKLTGNC 19 "Nigroain-B1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Bridge Not found None PTM: Contains one disulfide bridge. "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.69 ?g/ml), S. aureus ATCC43300 (MIC=50.00 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa PA01 (MIC=25.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25.00 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys13 and Cys19) Disulfide bridge between Cys13 and Cys19. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01539 FKTWKRPPFQTSCWGIIKE 19 "Nigroain-C2 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=27.50 ?g/ml), S. aureus ATCC43300 (MIC=55.00 ?g/ml), Bacillus subtilis (MIC=110.00 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=110.00 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=55.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=55.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=13.75 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01546 SLWETIKNAGKGFIQNLDKIR 21 "Nigroain-K1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. Also has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=21.88 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=32.74 ?g/ml)." [Ref:19778602]22.49 4.8% hemolytic activity at 100 ?g/ml against rabbit red cells Linear Free Free Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01549 GLLSVLGSVAKHVLPHVVPVIAEHL 25 "Caerin-1.1 (Frogs, amphibians, animals)" "P62568, P62569, Q800R2, P56226" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria splendida (Magnificent tree frog) (Litoria gilleni) (Litoria caerulea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Alpha helix The peptide adopts two well-defined helices from Leu2 to Lys11 and from Val17 to His24 separated by a region of less-defined helicity and greater flexibility. None "Function: Antibacterial and antiviral peptides that adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Secreted by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility. Miscellaneous: Caerin 1.1 completely inhibits HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606). PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=1.5 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12.5 ?g/ml), Staphylococcus aureus (MIC=3-12 ?g/ml), Staphylococcus epidermis (MIC=12.5 ?g/ml), Streptococcus uberis (MIC=12.5 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml).##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=7.8 M);inhibition of HIV transfer by dendritic cells to T cells(IC50=12.6 M)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Cell membrane 16140737##9266696##12709067##15203252 J Virol. 2005 Sep;79(18):11598-606. ##Eur J Biochem. 1997 Jul 15;247(2):545-557.##Eur J Biochem. 2003 May;270(9):2068-2081.##Peptides. 2004 Jun;25(6):1035-1054. "VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Wong H, Bowie JH, Carver JA.##Vanhoye D, Bruston F, Nicolas P, Amiche M.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.##Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01550 GLLGAMFKVASKVLPHVVPAITEHF 25 "Caerin-1.11 (Frogs, amphibians, animals)" Q800R9 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None "Function: Antibacterial and antiviral peptides that adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity (By similarity). PTM: C-terminal amidation." "Gram-negative bacteria: Escherichia coli B (MIC=25 ?M), Enterobacter cloacae (MIC=50 ?M), Klebsiella pneumoniae (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus haemolyticus (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.12709067]No cytotoxicity information found##[Ref.22771617]No cytotoxicity information found Not found 12709067##22771617 Eur J Biochem. 2003 May;270(9):2068-2081.##Peptides. 2012 Sep;37(1):174-188. "Vanhoye D, Bruston F, Nicolas P, Amiche M.##Bowie JH, Separovic F, Tyler MJ." "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Host-defense peptides of Australian anurans. Part 2. Structure, activity, mechanism of action, and evolutionary significance." DRAMP01552 GLLSVLGSVAQHVLPHVVPVIAEHL 25 "Caerin-1.3 (Frogs, amphibians, animals)" P56228 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Australian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Staphylococcus aureus (MIC=6-12 ?g/ml), Staphylococcus epidermis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). (Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01553 GLLSSLSSVAKHVLPHVVPVIAEHL 25 "Caerin-1.4 (Frogs, amphibians, animals)" "P62544, P56229, P62545, P56229" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) (also Litoria gilleni) (Centralian tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=0.4 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=100 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=50 ?g/ml), Pasteurella multocida (MIC=25 ?g/ml). (Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01555 GLLSVLGSVVKHVIPHVVPVIAEHL 25 "Caerin-1.5 (Frogs, amphibians, animals)" P56230 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). ##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 12.5 ?M. Not found 26026377##15203252##PubMed ID is not available Peptides. 2015 Sep;71:296-303. ##Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01560 GLFGVLGSIAKHVLPHVVPVIAEKL 25 "Caerin-1.9 (Frogs, amphibians, animals)" P81252 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria chloris (Blue-thighed frog) (frog skin active peptide family) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin dorsal glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation. Miscellaneous: Caerin 1.9 completely inhibited HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606)." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=50 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=1.2 M);inhibition of HIV transfer by dendritic cells to T cells(IC50=1.6 M).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 20 ?M." Not found 26026377##16140737##15203252##9516047 Peptides. 2015 Sep;71:296-303. ##J Virol. 2005 Sep;79(18):11598-606. ##Peptides. 2004 Jun;25(6):1035-1054.##J Pept Res. 1998 Feb;51(2):121-126. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria." DRAMP01562 GLVSSIGRALGGLLADVVKSKGQPA 25 "Caerin-2.1 (Frogs, amphibians, animals)" "P56233, P86485" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria splendida (Magnificent tree frog) (Emerald spotted tree frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). (Ref.2) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.15203252]No cytotoxicity information found##[Ref.19642086]No cytotoxicity information found Not found 15203252##19642086 Peptides. 2004 Jun;25(6):1035-1054.##Rapid Commun Mass Spectrom. 2009 Sep;23(17):2628-2636. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Bilusich D, Jackway RJ, Musgrave IF, Tyler MJ, Bowie JH." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##The host-defence skin peptide profiles of Peron's Tree Frog Litoria peronii in winter and summer. Sequence determination by electrospray mass spectrometry and activities of the peptides." DRAMP01563 GLVSSIGRALGGLLADVVKSKEQPA 25 "Caerin-2.2 (Frogs, amphibians, animals)" "P62570, P62571, P56234" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gilleni (Centralian tree frog) (also Litoria caerulea) (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." Gram-positive bacterium: Micrococcus luteus (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01574 GLWQKIKSAAGDLASGIVEGIKS 23 "Caerin-4.1 (Frogs, amphibians, animals)" P56242 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Alpha helix Not found None "PTM: adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." [Ref.15203252]Gram-positive bacterium: Micrococcus luteus (MIC=12 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01576 GLWQKIKNAAGDLASGIVEGIKS 23 "Caerin-4.3 (Frogs, amphibians, animals)" P56244 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. PTM: C-terminal amidation." Gram-positive bacterium: Micrococcus luteus (MIC=25 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=50 ?g/ml).(Ref.2) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01577 GLLSVLGSVAKHVLPHVVPVIAEKL 25 "Caerin-1.10 (Frogs, amphibians, animals)" "P86502, P82104" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria rothii (Roth's tree frog); also Litoria splendida (Magnificent tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide with wide spectrum of activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.10601876]Gram-positive bacteria: Leuconostoc lactis (MIC=6 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml), Staphylococcus epidermidis (MIC=100 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=100 ?g/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 22 ?M." Not found 26026377##16124032##10601876 Peptides. 2015 Sep;71:296-303. ##Rapid Commun Mass Spectrom. 2005;19(18):2716-2724.##Eur J Biochem. 2000 Jan;267(1):269-275. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Brinkworth CS, Bowie JH, Bilusich D, Tyler MJ.##Wabnitz PA, Bowie JH, Tyler MJ, Wallace JC, Smith BP." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##The rothein peptides from the skin secretion of Roth's tree frog Litoria rothii. Sequence determination using positive and negative ion electrospray mass spectrometry.##Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10." DRAMP01585 GLFSVLGSVAKHLLPHVVPVIAEKL 25 "Caerin-1.18 (Frogs, amphibians, animals)" P0C2A7 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gracilenta (Dainty green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=25 ?g/ml), Listeria innocua (MIC=12 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus ATCC 25923 (MIC=12 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=25 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacteria: Pasteurella multocida (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16554081]No cytotoxicity information found Not found 16554081 Toxicon. 2006 May;47(6):664-675. "Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ." New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. DRAMP01586 GLFKVLGSVAKHLLPHVAPIIAEKL 25 "Caerin-1.19 (Frogs, amphibians, animals)" P0C2A8 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gracilenta (Dainty green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Caerin-1.19 shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "[Ref.16554081]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=12 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Staphylococcus aureus Strain ATCC 25923 (MIC=12 ?g/ml), Staphylococcus aureus Strain ATCC 29213 (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacteria: Pasteurella multocida (MIC=50 ?g/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Not found 26026377##16554081 Peptides. 2015 Sep;71:296-303. ##Toxicon. 2006 May;47(6):664-675. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ." Inhibition of HIV infection by caerin 1 antimicrobial peptides.##New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. DRAMP01590 GLFDVIAKVASVIKKL 16 "Citropin 1.1 M14 (Frogs, amphibians, animals)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: E. coli (MIC=53 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.20564028]No cytotoxicity information found Not found 20564028 Biopolymers. 2011;96(2):147-157. "Chia CS, Gong Y, Bowie JH, Zuegg J, Cooper MA. " "Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin." DRAMP01591 GLFAVIKKVASVIKKL 16 "Citropin 1.1 M15 (Frogs, amphibians, animals)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: E. coli (MIC=53 ?M);##Gram-positive bacteria: S. aureus (MIC=3 ?M), B. subtilis (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.20564028]No cytotoxicity information found Not found 20564028 Biopolymers. 2011;96(2):147-157. "Chia CS, Gong Y, Bowie JH, Zuegg J, Cooper MA. " "Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin." DRAMP01607 GLFDIIKKIAESF 13 "Aurein-1.2 (Frogs, amphibians, animals)" P82387 Not found Not found Litoria raniformis (Southern bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Alpha helix (1 helices; 10 residues) Not found 1VM5 resolved by NMR. Function: Probably acts by disturbing membrane functions with its amphipathic structure. Aurein 1.2 is HIV active (Wang G et al. 2010 Antimicrob. Agents Chemother. (54) 1343-1346). Aurein 1.2 is also the smallest amphibian peptide to show both antibiotic and Anti-cancer activity. The aurein antibiotics show more activity towards Gram-positive than Gram-negative pathogens. Expressed by the skin dorsal glands. "Gram-positive bacteria: Bacillus cereus (MIC=100 g/ml), Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=50 g/ml), Staphylococcus aureus (MIC=8 mol/L);##Gram-negative bacteria: Pasteurella multocida (MIC=100 g/ml), Escherichia coli (MIC=8 mol/L);##Fungi: Candida albicans (MIC=32 mol/L)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found##[Ref.15572363]No cytotoxicity information found Cell membrane 10951191##15572363##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##J Biol Chem. 2005 Feb 18;280(7):5803-5811.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Wang G, Li Y, Li X.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01618 GLFDIVKKIAGHIVSSI 17 "Aurein-3.3 (Frogs, amphibians, animals)" P82396 Not found Not found Litoria raniformis (blue-thighed treefrog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=12 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=25 g/ml), Staphylococcus aureus (MIC=100 g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=100 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01621 IIGPVLGMVGSALGGLLKKI 20 "Bombinin-H1 (Frogs, amphibians, animals)" "P82282, P82283" Belongs to the bombinin family Not found Bombina variegata (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation and D-amino acid." [Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=3.8 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=2.1 ?M). [Ref:8223491]Not determined hemolytic activity against human red blood cells. Linear Free Amidation Free L [Ref.8223491]No cytotoxicity information found Not found 8223491 EMBO J. 1993 Dec;12(12):4829-4832. "Mignogna G, Simmaco M, Kreil G, Barra D." Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata. DRAMP03722 IFGAIWNGIKSLF 13 Cytotoxic linear peptide IsCT2 Q8MTX2 Belongs to the scorpion NDBP 5 family Not found Opisthacanthus madagascariensis (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: IsCT2 showed broad activity spectra against microbes (Gram positive and negative bacteria as well as fungi). Has hemolytic activity. "[Ref.12054688] Gram-negetive bacteria: P.aeroginosa ATCC 15442 (MIC>150 M), P.aeroginosa ATCC 27853 (MIC=68.3 M), E.coli CCT 1371 (MIC=3.4 M), Escherichia coli ATCC 25922 (MIC=6.8 M), P. mirabilis (MIC>150 M);## Gram-positive bacteria: S.aureus ATCC 25293 (MIC=0.7 M), S.aureus ATCC 6538 (MIC=3.4 M), S.saprophyticus (MIC=0.7 M), B.thuringensis (MIC=17.1 M), B.subtilis CCT 2471 (MIC=6.8M).##[Ref.28657596] Gram-positive bacterium:Staphylococcus aureus (MIC=50g/mL), B. cereus (MIC=100g/mL);##Gram-negative bacterium: S. typhimurium (MIC=100g/mL), Escherichia coli (MIC=50g/mL)" "[Ref.12054688] Showed relatively weak hemolytic activity against sheep red blood cells.##[Ref.28657596] 18% hemolysis at 10 g/ml, 96% hemolysis at 50 g/ml against human red blood cells." Linear Free Amidation Free L [Ref.12054688]No cytotoxicity information found##[Ref.28657596]No cytotoxicity information found Not found 12054688##28657596 Biochem Biophys Res Commun. 2002 May 24;293(5):1514-1522.##Antibiotics (Basel). 2017 Jun 28;6(3). pii: E13. "Dai L, Corzo G, Naoki H, Andriantsiferana M, Nakajima T.##de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM." "Purification, structure-Function: analysis, and molecular characterization of novel linear peptides from scorpion Opisthacanthus madagascariensis.##Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides" DRAMP01626 IIGPVLGLVGSALGGLLKKI 20 "Bombinin-H5 (Frogs, amphibians, animals)" P82285 Belongs to the bombinin family Not found Bombina variegata (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix (1 helices; 16 residues) Not found "2AP7, 2AP8 resolved by NMR." "Function: Has antimicrobial activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation and D-amino acid." [Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=5.0 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.0 ?M). [Ref:8223491]Not found Linear Free Amidation Free Mixed (2D-aIle(alloisoleucine)) [Ref.8223491]No cytotoxicity information found Not found 8223491##PubMed ID is not available EMBO J. 1993 Dec;12(12):4829-4832##TO BE PUBLISHED "Mignogna G, Simmaco M, Kreil G, Barra D.##Zangger K, Jilek A, Khatai L." Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.##Solution structure and orientation of bombinin H2 and H4 in a membrane-mimetic environment. DRAMP01627 YPPKPESPGEDASPEEMNKYLTALRHYINLVTRQRY 36 "Skin peptide tyrosine-tyrosine (Skin-PYY; SPYY; Frogs, amphibians, animals)" P80952 Belongs to the NPY family Not found Phyllomedusa bicolor (Two-colored leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria, yeast and fungi. Tissue specificity: Skin. PTM: C-terminal amidation (By similarity)." "Gram-negative bacteria: Aeromonas caviae (MIC=40 ?g/ml), Escherichia coli (MIC=10 ?g/ml);##Gram-positive bacteria: Enterococcus faecalis (MIC=10 ?g/ml), Nocardia brasiliensis (MIC=20 ?g/ml).##Fungi: Cryptococcus neoformans (MIC=20 ?g/ml), Candida albicans (MIC=15 ?g/ml), Microsporum canis (MIC=10 ?g/ml), Tricophyton rubrum (MIC=15 ?g/ml), Arthroderma simii (MIC=10 ?g/ml), Aspergillus fumigatus (MIC=80 ?g/ml), Aspergillus niger (MIC>100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.8601432]<20% cytotoxic against murine macrophages at the concentration up to 100g/ml##[Ref.7937944]No cytotoxicity information found Cell membrane 7937944##8601432 Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10295-10299.##FEBS Lett. 1996 Feb 19;380(3):237-240. "Mor A, Chartrel N, Vaudry H, Nicolas P.##Vouldoukis I, Shai Y, Nicolas P, Mor A." "Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.##Broad spectrum antibiotic activity of the skin-PYY." DRAMP01628 GWMSKIASGIGTFLSGMQQ 19 "Phylloxin (Frogs, amphibians, animals)" "P81565, Q9PT74" Belongs to the frog skin active peptide family (Dermaseptin subfamily) PLX Phyllomedusa bicolor (Two-colored leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None "Function: Antimicrobial peptide against the Gram-positive bacteria and the Gram-negative-bacteria. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "Gram-negative bacteria: Acholeplasma laidlawii A-PG8 (MIC=12.5 ?M), Spiroplasma melliferum BC3 (MIC=50 ?M), Rhizobium meliloti 102F34 (MIC=12.5 ?M), Escherichia coli K12 (MIC=10 ?M);##Gram-positive bacteria: Bacillus megaterium KM (MIC=3.12 ?M), Corynebacterium glutamicum ATCC 27853 (MIC=1.56 ?M), Micrococcus luteus ATCC 27853 (MIC=3.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10632707]No cytotoxicity information found Not found 10632707 Eur J Biochem. 2000 Jan;267(2):370-378. "Pierre TN, Seon AA, Amiche M, Nicolas P." "Phylloxin, a novel peptide antibiotic of the dermaseptin family of antimicrobial/opioid peptide precursors." DRAMP01638 GLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS 32 "Dermaseptin-L1 (Frogs, amphibians, animals)" No entry found Not found Not found Hylomantis lemur (Lemur leaf frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=8 ?M).##Fungi: Batrachochytrium dendrobatidis (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17561225]Displayed cytotoxic against HepG2 cells(LC50=45M) Not found 17561225 Toxicon. 2007 Sep 15;50(4):498-506. "Conlon JM, Woodhams DC, Raza H, Coquet L, Leprince J, Jouenne T, Vaudry H, Rollins-Smith LA." Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae). DRAMP01639 GLWSTIKNVGKEAAIAAGKAALGAL 25 "Dermaseptin-1 (DShypo01, DPh-1; Frogs, amphibians, animals)" P84596 Not found Not found Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also has antiprotozoal activity against L. amazonensis. No hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.16963159]Gram-positive bacteria: Micrococcus luteus A270 (MIC=6 ?M), Staphylococcus aureus ATCC 6538 (MIC=6 ?M);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=6 ?M), Pseudomonas aeruginosa ATCC 14502 (MIC=6.6 ?M)." [Ref:16844081]Non-hemolytic activity upto 53 M against human red blood cells;##[Ref.16963159]Non-hemolytic activity at 6 M against erythrocytes Linear Free Amidation Free L [Ref.16844081]No cytotoxicity information found##[Ref.16963159]No cytotoxicity information found Not found 16844081##16963159 Biochem Biophys Res Commun. 2006 Sep 1;347(3):739-746.##Peptides. 2006 Dec;27(12):3092-3099. "Brand GD, Leite JR, de S?? Mandel SM, Mesquita DA, Silva LP, Prates MV, Barbosa EA, Vinecky F, Martins GR, Galasso JH, Kuckelhaus SA, Sampaio RN, Furtado JR Jr, Andrade AC, Bloch C Jr.##Concei???o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC." Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).##Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis. DRAMP01643 GLWSTIKQKGKEAAIAAAKAAGQAALGAL 29 "Dermaseptin-5 (DShypo05, DS 01; Frogs, amphibians, animals)" P84600 Not found Not found Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also has antiprotozoal activity against L. amazonensis. No hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." [Ref.8306981]Gram-negative bacterium: Escherichia coli (MIC=6.4 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3.2 ?M). [Ref:8306981]Non-hemolytic activity against rabbit red blood cells. Linear Free Amidation Free L [Ref.12379643]No cytotoxicity information found##[Ref.17442605]No cytotoxicity information found Not found 12379643##17442605 J Biol Chem. 2002 Dec 20;277(51):49332-49340. ##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):336-343. "Brand GD, Leite JR, Silva LP, Albuquerque S, Prates MV, Azevedo RB, Carregaro V, Silva JS, S VC, Brand?o RA, Bloch C Jr. ##Leite JRSA, Brand GD, Silva LP, Kckelhaus SAS, Bento WRC, Arajo ALT, Martins GR, Lazzari AM, Bloch C Jr." "Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells. ##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity. " DRAMP01646 GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV 33 "Adenoregulin (Dermaseptin BII; Dermaseptin B2; Frogs, amphibians, animals)" "P31107, P80283" Belongs to the frog skin active peptide family (Dermaseptin subfamily) ADR Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Fountion: Enhances binding of agonists to adenosine A1 receptors, adenosine A2a receptors, alpha-2 adrenergic receptors and 5-hydroxytryptamine 1A receptors. Enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. Affects human behavior eliciting profound malaise, followed by listlessness and then euphoria. Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Lack hemolytic activity. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation at V33 (Amidation in vitro increases antimicrobial activity against some microorganisms such as T. album and S. cerevisia)." "[Ref.8306981]Fungi: Microsporum canis (IP 1194) (MIC=10 ?g/ml), Tricophyton rubrum (IP 1400-82) (MIC=15 ?g/ml), Arthroderma simii (IP 1063-74) (MIC=30 ?g/ml), Aspergillus fumigatus IP (1025-70) (MIC=125 ?g/ml), Aerornonas caviae (IP 67-16 T) (MIC=60 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 ?g/ml), Candida albicans (IP 884-65) (MIC=15 ?g/ml);##Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=15 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=30 ?g/ml)." [Ref:8306981]Lack hemolytic activity against rabbit red blood cells Linear Free Free Free L [Ref.8306981]No cytotoxicity information found##[Ref.1438301]No cytotoxicity information found##[Ref.7842473]No cytotoxicity information found##[Ref.8565049]No cytotoxicity information found Not found 8306981##1438301##7842473##8565049 "Eur J Biochem 1994, 219 (1-2):145-154.##Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-10963.##Cell Mol Neurobiol. 1994 Apr;14(2):133-157.##Cell Mol Neurobiol. 1995 Aug;15(4):465-493." "Mor, A, Nicolas, P.##Daly JW, Caceres J, Moni RW, Gusovsky F, Moos M Jr, Seamon KB, Milton K, Myers CW.##Shin Y, Moni RW, Lueders JE, Daly JW.##Moni RW, Romero FS, Daly JW." "Isolation and structure of novel defensive peptides from frog skin.##Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor.##Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx.##The amphiphilic peptide adenoregulin enhances agonist binding to A1-adenosine receptors and [35S]GTP gamma S to brain membranes." DRAMP01648 GLVTSLIKGAGKLLGGLFGSVTGGQS 26 "Dermaseptin-like PBN2 (DRP-PBN2; Plasticin-B1a; Frogs, amphibians, animals)" Q800R4 Not found Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Possesses a potent antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and fungi. Probably acts by disturbing membrane functions with its amphipathic structure." "Gram-negative bacteria: Escherichia coli B (MIC=1.5 ?M), Salmonella typhimurium (MIC=3.1 ?M), Salmonella enteritidis (MIC=1.5 ?M), Enterobacter cloacae (MIC=12.5 ?M), Klebsiella pneumoniae (MIC=0.8 ?M);##Gram-positive bacteria: Aerococcus viridans (MIC=3.1 ?M), Bacillus megaterium (MIC=0.8 ?M), Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus haemolyticus (MIC=0.8 ?M).##Fungi: Saccaromyces cerevisiae (MIC=3.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.12709067]No cytotoxicity information found##[Ref.15222751]No cytotoxicity information found Not found 12709067##15222751 Eur J Biochem. 2003 May;270(9):2068-2081.##Biochemistry. 2004 Jul 6;43(26):8391-8409. "Vanhoye D, Bruston F, Nicolas P, Amiche M.##Vanhoye D, Bruston F, El Amri S, Ladram A, Amiche M, Nicolas P." "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Membrane association, electrostatic sequestration, and cytotoxicity of Gly-Leu-rich peptide orthologs with differing functions." DRAMP01649 AMWKDVLKKIGTVALHAGKAALGAVADTISQ 31 "Dermaseptin-BI (Dermaseptin B1; Frogs, amphibians, animals)" P80282 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation (Potential)." "Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=15 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=30 ?g/ml).##Fungi: Tricophyton rubrum (IP 1400-82) (MIC=15 ?g/ml), Microsporum canis (IP 1194) (MIC=10?g/ml), Arthroderma simii (IP 1063-74) (MIC=30 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neofonnans (IP 962-67) (MIC=15 ?g/ml), Aspergillus fumigatus (IP 1025-70)(MIC=125 ?g/ml), Aerornonas caviae (IP 67-16 T) (MIC=60 ?g/ml), Candida albicans (IP 884-65) (MIC=15 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.8306981]No cytotoxicity information found##[Ref.8074751]No cytotoxicity information found Not found 8306981##8074751 Eur J Biochem. 1994 Jan 15;219(1-2):145-154.##J Biol Chem. 1994 Jul 8;269(27):17847-17852. "Mor A, Nicolas P.##Amiche M, Ducancel F, Mor A, Boulain JC, Menez A, Nicolas P." "Isolation and structure of novel defensive peptides from frog skin.##Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins." DRAMP01650 ALWKNMLKGIGKLAGQAALGAVKTLVGAE 29 "Dermaseptin-B3 (Dermaseptin BIII; Frogs, amphibians, animals)" P81485 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands." "Gram-negative bacteria: Pseudomonas aeruginosa CIP A22 (MIC=2.3 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=5 ?M), Escherichia coli ATCC 25922 (MIC=2.6 ?M), E. coli 54127 (MIC=2.3 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25293 (MIC=1.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.9614066]No cytotoxicity information found Not found 9614066 J Biol Chem. 1998 Jun 12;273(24):14690-14697. "Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A." "Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics." DRAMP01651 ALWKDILKNVGKAAGKAVLNTVTDMVNQ 28 "Dermaseptin-B4 (Dermaseptin BIV; Frogs, amphibians, animals)" P81486 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None "Function: Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus ATCC 25293 (MIC=1.3 ?M), S. aureus ATCC 25923 (MIC=3.0 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa CIP A22 (MIC=4.6 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=11.6 ?M), Escherichia coli ATCC 25922 (MIC=5.0 ?M), E. coli 54127 (MIC=2.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.9614066]No cytotoxicity information found Not found 9614066 J Biol Chem. 1998 Jun 12;273(24):14690-14697. "Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A." "Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics." DRAMP01668 ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ 34 "Dermaseptin-1 (DS I; Dermaseptin-S1, DS1; Frogs, amphibians, animals)" "P24302, P80277" Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa sauvagei (Sauvage's leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (CD) Not found None "Function: Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. This peptide could also inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). Tissue specificity: Expressed by the skin glands." "Fungi: Microsporum canis (IP 1194) (MIC=50 ?g/ml), Tricophyton rubrum (IP 1400-82) (MIC=100 ?g/ml), Arthroderma simii (IP 1063-74) (MIC=100 ?g/ml), Aspergillus fumigatus (IP 1025-70) (MIC=100 ?g/ml), Aerornonas caviae IP (67-16) T (MIC=50 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 ?g/ml), Candida albicans (IP 884-65) (MIC=60 ?g/ml); ##Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=5 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=200 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.1909573]No cytotoxicity information found##[Ref.8306981]No cytotoxicity information found Cell membrane 1909573##8306981 Biochemistry. 1991 Sep 10;30(36):8824-8830.##Eur J Biochem. 1994 Jan 15;219(1-2):145-154. "Mor A, Nguyen VH, Delfour A, Migliore-Samour D, Nicolas P.##Mor A, Nicolas P." "Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin.##Isolation and structure of novel defensive peptides from frog skin." DRAMP01702 GLWSTIKNVGKEAAIAAGKAVLGSL 25 "Dermaseptin-H5 (Dermaseptin-like peptide 5, DMS5; Frogs, amphibians, animals)" Q1EJP4 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None MOA: Probably acts by disturbing membrane functions with its amphipathic structure (By similarity). "Gram-negative bacterium: Escherichia coliEscherichia coli ATCC 11775 (MIC=0.5 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (MIC=0.5 ?M), Micrococcus luteus ATCC 49732 (MIC=2.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17553595]No cytotoxicity information found Not found 17553595 Peptides. 2007 Jul;28(7):1331-1343. "Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S." A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea. DRAMP01731 FLPIAGKLLSGLSGLL 16 "Temporin-ALd (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALd exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1.25 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=15 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)." [Ref:19843479]12% hemolytic activity at 100 g/mL against rabbit red blood cells Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01732 FFPIVGKLLFGLSGLL 16 "Temporin-ALe (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALe exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=5 ?g/mL), Bacillus cereus (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1.25 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=15 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)." [Ref:19843479]10% hemolytic activity at 100 g/mL against rabbit red blood cells Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01733 FFPIVGKLLSGLSGLL 16 "Temporin-ALf (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALf exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=5 ?g/mL), Bacillus cereus (MIC=30 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=2.5 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=30 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)." [Ref:19843479]7% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01734 FFPIVGKLLFGLFGLL 16 "Temporin-ALg (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALg exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=30 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?g/mL), Bacillus dysenteriae (MIC=10 ?g/mL), Acinetobacter calcoaceticus (MIC=30 ?g/mL), Psecdomonas aeruginosa (MIC=7.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)." [Ref:19843479]16% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01735 FLPIVGKLLSGLSGLS 16 "Temporin-ALh (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALh exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=7.5 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?g/mL), Bacillus dysenteriae (MIC=20 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=2.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)." [Ref:19843479]13% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01736 FFPIVGKLLSGLL 13 "Temporin-ALi (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALi exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=7.5 ?g/mL), Bacillus pumilus (MIC=7.5 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=7.5 ?g/mL), Bacillus dysenteriae (MIC=20 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=5 ?g/mL)." [Ref:19843479]21% hemolytic activity at 100 g/mL against rabbit red blood cells Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01737 FFPIVGKLLFGLL 13 "Temporin-ALj (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALg exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=7.5 ?g/mL), Bacillus pumilus (MIC=15 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=15 ?g/mL), Bacillus dysenteriae (MIC=30 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=7.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=5 ?g/mL)." [Ref:19843479]19% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01738 FFPIVGKLLS 10 "Temporin-ALk (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALk exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacterium: Staphylococcus aureus ATCC2592 (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 ?g/mL), Bacillus dysenteriae (MIC=60 ?g/mL), Acinetobacter calcoaceticus (MIC=75 ?g/mL), Psecdomonas aeruginosa (MIC=25 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=15 ?g/mL)." [Ref:19843479]25% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01753 FVDLKKIANIINSIFGK 17 "Temporin-1CEa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chensinensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Alpha helix Not found None Function: Temporin-1CEa exhibits the greatest ability to inhibit the growth of MCF-7 cells. Also temporin-1CEa shows hemolytic effect to human erythrocytes and has no significant cytotoxicity to normal HUVSMCs at concentrations showed potent antitumor activity. "[Ref.21871946]Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 ?M), Bacillus cereus (MIC=14.4 ?M), Streptococcus lactis (MIC=14.4 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M)." [Ref:21871946]LD50=99.08 M against human erythrocytes Linear Free Amidation Free L [Ref.19341344]No cytotoxicity information found##[Ref.21871946]No determined cytotoxic against SMCs at the concentration between 20-60 M. Not found 21871946##19341344 Biochimie. 2012 Feb;94(2):434-441.##Zoolog Sci. 2009 Mar;26(3):220-226. "Wang C, Li HB, Li S, Tian LL, Shang DJ.##Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y." "Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis).##Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis." DRAMP01754 ILPILSLIGGLLGK 14 "Temporin-1CEb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chensinensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus (MIC=41 ?M), Bacillus cereus (MIC=41 ?M), Streptococcus lactis (MIC=41 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19341344]No cytotoxicity information found Not found 19341344 Zoolog Sci. 2009 Mar;26(3):220-226. "Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y." "Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis." DRAMP01755 FLGALAKIISGIF 13 "Temporin-1TSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tsushimensis (Tsushima brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16413829]No cytotoxicity information found Not found 16413829 Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. "Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. DRAMP01764 FLPILGKLLSGIL 13 "Temporin-1TGa (Frogs, amphibians, animals)" Q2PGA8 Belongs to the frog skin active peptide family (Brevinin subfamily) tmpTGa Rana tagoi (Tago frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M).##Yeast: Candida albicans. No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.12804591]No cytotoxicity information found##[Ref.16675060]No cytotoxicity information found Not found 12804591##16675060 Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.##Peptides. 2006 Sep;27(9):2124-2128. "Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, P??l T.##Iwamuro S, Nakamura M, Ohnuma A, Conlon JM." "A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties.##Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi." DRAMP01765 AVDLAKIANKVLSSLF 16 "Temporin-1TGb (Frogs, amphibians, animals)" Q2PGA7 Belongs to the frog skin active peptide family (Brevinin subfamily) tmpTGb Rana tagoi (Tago frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC>150 ?M);##Gram-negative bacterium: Escherichia coli (MIC=37.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16675060]No cytotoxicity information found Not found 16675060 Peptides. 2006 Sep;27(9):2124-2128. "Iwamuro S, Nakamura M, Ohnuma A, Conlon JM." Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi. DRAMP01766 FLPVILPVIGKLLSGIL 17 "Temporin-1TGc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tagoi (Tago's brown frog); also Rana sakuraii "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=37.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC>150 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16675060]No cytotoxicity information found Not found 16675060 Peptides. 2006 Sep;27(9):2124-2128. "Iwamuro S, Nakamura M, Ohnuma A, Conlon JM." Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi. DRAMP01771 FLPLLASLFSRLL 13 "Temporin-1Oa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana ornativentris (Japanese mountain brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=70 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17147973]No cytotoxicity information found Not found 17147973 Peptides. 2007 Mar;28(3):524-532. "Ohnuma A, Conlon JM, Yamaguchi K, Kawasaki H, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Japanese mountain brown frog Rana ornativentris: evidence for polymorphism among preprotemporin mRNAs. DRAMP01775 FLSGIVGMLGKLFGK 15 "Temporin-1Sa (Frogs, amphibians, animals)" B3KYH4 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-1Sa Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Activity against Gram-positive and Gram-negative bacteria, and has hemolytic activity against human erythrocytes." "[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3 ?M), Enterococcus faecalis ATCC 29212 (MIC=10 ?M), Bacillus megaterium (MIC=2 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10 ?M), Escherichia coli ATCC 35218 (MIC=10 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=31 ?M);##Fungi: Candida albicans ATCC 90028 (MIC=16 ?M), Candida parapsilosis ATCC 22019 (MIC=31 ?M), Saccharomyces cerevisiae (MIC=8 ?M)." [Ref:18584916]LC50=25 M against human erythrocytes Linear Free Amidation Free L [Ref.18584916]No cytotoxicity information found Not found 18584916 Peptides. 2008 Sep;29(9):1526-1523. "Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A" "Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica." DRAMP01776 FLPIVTNLLSGLLGK 15 "Temporin-1Sb (Temporin-SHb; Frogs, amphibians, animals)" B3KYH5 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-1Sb Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Activity against Gram-positive and Gram-negative bacteria, and has strong hemolytic activity against human erythrocytes." "[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=58 ?M), Enterococcus faecalis ATCC 29212 (MIC>116 ?M), Bacillus megaterium (MIC=46 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=231 ?M), Escherichia coli ATCC 35218 (MIC>116 ?M);##Fungi: Aspergillus flavus (MIC=58 ?M)." [Ref:18584916]LC50>116 M against human erythrocytes Linear Free Amidation Free L [Ref.18584916]No cytotoxicity information found Not found 18584916 Peptides. 2008 Sep;29(9):1526-1523. "Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A" "Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica." DRAMP01777 FLSHIAGFLSNLFGK 15 "Temporin-1Sc (Temporin-SHc; Frogs, amphibians, animals)" B3KYH6 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-1Sc Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and has hemolytic activity against human erythrocytes." "[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC>80 ?g/ml), Bacillus megaterium (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=161 ?g/ml), Escherichia coli ATCC 35218 (MIC>80 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>161 ?g/ml);##Fungi: Aspergillus flavus (MIC=10 ?g/ml), Candida albicans ATCC 90028 (MIC=20 ?g/ml), Candida parapsilosis ATCC 22019 (MIC=20 ?g/ml), Saccharomyces cerevisiae (MIC=10 ?g/ml)." [Ref:18584916]LC50>80 M against human erythrocytes Linear Free Amidation Free L [Ref.18584916]No cytotoxicity information found Not found 18584916 Peptides. 2008 Sep;29(9):1526-1523. "Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A" "Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica." DRAMP01779 FFFLSRIFGK 10 "Temporin-SHf (Frogs, amphibians, animals)" D4YWD1 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-SHf Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25-200 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.20308076]No cytotoxicity information found Not found 20308076 J Biol Chem. 2010 May 28;285(22):16880-16892. "Abbassi F, Lequin O, Piesse C, Goasdoue N, Foulon T, Nicolas P, Ladram A." "Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide." DRAMP01780 FLSGIVGMLGKLF 13 "Temporin-SHa (Temporin-1Sa; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Pelophylax saharica (North Africa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Bacillus megaterium (MIC=2 ?M);##Gram-negative bacterium: Escherichia coli (MIC=10 ?M).##Yeast: Candida albicans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.31614561]Display cytotoxic against human gastric cells(N87 cell:IC50=1558 324M) Not found 31614561 Biomolecules. 2019 Oct 11;9(10):598. "Olleik H, Baydoun E, Perrier J, Hijazi A, Raymond J, Manzoni M, Dupuis L, Pauleau G, Goudard Y, Villon B, Goin G, Sockeel P, Choudhary MI, Pasquale ED, Nadeem-Ul-Haque M, Ali H, Khan AI, Shaheen F, Maresca M. " Temporin-SHa and Its Analogs as Potential Candidates for the Treatment of Helicobacter pylori. DRAMP01784 SLSRFLSFLKIVYPPAF 17 "Temporin-LTc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii (broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Not found Not found Not found None Comment: A mutant of the peptide is also HIV inhibitory (Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346). "Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?g/ml), Bacillus subtilis (MIC=50 ?g/ml);##Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19022312]No cytotoxicity information found Not found 19022312 Peptides. 2009 Feb;30(2):273-282. "Wang H, Lu Y, Zhang X, Hu Y, Yu H, Liu J, Sun J." "The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae)." DRAMP01785 IPPFIKKVLTTVF 13 "Temporin-CPa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates capito (New World frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: For this series of peptides, there were not enough material for antimicrobial assays. It displayed hemolytic activity (human red blood cells) at LC50=220 uM. " [Ref.19635516]Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=50 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=25 ?M). [Ref:19635516]LC50=220 M against human erythrocytes Linear Free Amidation Free L [Ref.19635516]No cytotoxicity information found Not found 19635516 Peptides. 2009 Oct;30(10):1775-1781. "Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). DRAMP01787 AILTTLANWARKFL 14 "Temporin-HN1 (Frogs, amphibians, animals)" E7EKD0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has hemolytic activity against washed human erythrocytes (IC50=75 ?M). "[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=37.5 ?M), Staphylococcus carnosus KHS (MIC=37.5 ?M), Bacillus licheniformis X39 (MIC=19 ?M), Rhodococcus rhodochrous X15 (MIC=4.8 ?M);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=75 ?M);##Fungi: Slime mould 090223 (MIC=19 ?M), Candida albicans ATCC2002 (MIC=75 ?M)." [Ref:22450466]IC50=75 ?M against washed human erythrocytes Linear Free Amidation Free L [Ref.22450466]No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP01788 NILNTIINLAKKIL 14 "Temporin-HN2 (Frogs, amphibians, animals)" E7EKD4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=4.8 ?M), Staphylococcus carnosus KHS (MIC=19 ?M), Bacillus licheniformis X39 (MIC=19 ?M),Rhodococcus rhodochrous X15 (MIC=2.4 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=37.5 ?M).##Fungi: Slime mould 090223 (MIC=9.5 ?M) and Candida albicans ATCC2002 (MIC=9.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.22450466]No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP01789 FLSSIGKILGNLL 13 "Temporin-1Va (Temporin 1Va; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: It also has weak hemolytic activty. "[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=10 ?M), S. aureus (MRSA) T7/20 (MIC=20 ?M), S. epidermidis RP62A (MIC=20 ?M), Enterococcus faecalis ATCC 29212 (MIC=40 ?M), Streptococcus group B HNTCC 80130 (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=40 ?M), Klebsiella pneumoniae KK3 9904 (MIC=80 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=160 ?M), Enterobacter cloacae HNTCC 53001 (MIC=40 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=160 ?M)." [Ref:15996769]LD50=120 M against washed human erythrocytes Linear Free Amidation Free L [Ref.15996769]No cytotoxicity information found Not found 15996769 Regul Pept. 2005 Nov;131(1-3):38-45. "Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR." "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP01791 FLPLVTMLLGKLF 13 "Temporin-1Vc (Temporin 1Vc; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: It also has weak hemolytic activty. "[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=5 ?M), S. aureus (MRSA) T7/20 (MIC=10 ?M), S. epidermidis RP62A (MIC=10 ?M), Enterococcus faecalis ATCC 29212 (MIC=40 ?M), Streptococcus group B HNTCC 80130 (MIC=40 ?M);##Gram-negative bacteria: Klebsiella pneumoniae KK3 9904 (MIC=80 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=160 ?M), Enterobacter cloacae HNTCC 53001 (MIC=40 ?M)." [Ref:15996769]LD50=30 M against washed human erythrocytes Linear Free Amidation Free L [Ref.15996769]No cytotoxicity information found Not found 15996769 Regul Pept. 2005 Nov;131(1-3):38-45. "Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR." "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP01807 FLPLVLGALSGILPKIL 17 "Temporin-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=4.69 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa PAO1 (MIC=4.7 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01808 FFPLLFGALSSHLPKLF 17 "Temporin-RN3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=3.75 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa PAO1 (MIC=3.75 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01811 FLKPLFNAALKLLP 14 "Temporin-Ra (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana ridibunda (marsh frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "At 60 ug/ml, the peptide showed about 1.3% hemolysis." "Gram-negative bacteria: Escherichia coli (MIC=24.2 ?g/ml), Klebsiella pneumoniae PTCC 1388 (MIC=31.2 ?g/ml);##Gram-positive bacteria: Streptococcus dysgalactiae PTCC 1074 (MIC=33.2 ?g/ml), Streptococcus agalactiae PTCC 1365 (MIC=24.7 ?g/ml) and Staphylococcus aureus PTCC 1431 (MIC=35.2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.21956830]No cytotoxicity information found Not found 21956830 J Pept Sci. 2012 Jan;18(1):10-16. "Asoodeh A, Zardini HZ, Chamani J." "Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda)." DRAMP01812 FLPVLAGVLSRA 12 "Temporin-Rb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana ridibunda (marsh frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "At 60 ug/ml, the peptide showed about 1.1% hemolysis. " "Gram-positive bacteria: Streptococcus dysgalactiae PTCC 1074 (MIC=21.8 ?g/ml), Streptococcus agalactiae PTCC 1365 (MIC=30.5 ?g/ml), Staphylococcus aureus PTCC 1431 (MIC=42.1 ?g/ml), Staphylococcus typhimurium (MIC=31.8 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=34.5 ?g/ml), Klebsiella pneumoniae PTCC 1388 (MIC=35.1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.21956830]No cytotoxicity information found Not found 21956830 J Pept Sci. 2012 Jan;18(1):10-16. "Asoodeh A, Zardini HZ, Chamani J." "Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda)." DRAMP01816 FLPIIGKLLSGLL 13 "Temporin-1CSb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=128 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17451843]No cytotoxicity information found Not found 17451843 Peptides 2007; 28: 1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP01817 FLPLVTGLLSGLL 13 "Temporin-1CSc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC>128 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=64 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17451843]No cytotoxicity information found Not found 17451843 Peptides 2007; 28: 1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP01818 NFLGTLVNLAKKIL 14 "Temporin-1CSd (Temporin-1DRb; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=64 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17451843]No cytotoxicity information found Not found 17451843 Peptides 2007; 28: 1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP03510 KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK 37 Cecropin A P01507 cecropin Not found Hyalophora cecropia "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha-helix Not found 1D9J Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. "[Ref.7140755] Gram-negative bacterium: Escherichia coli D21 (LC=0.19 ?M), Escherichia coli D31 (LC=0.21 ?M), Serratia marcescens Db11 (LC=4.2 ?M), Serratia marcescens Db1108 (LC=2.5 ?M), Serratia marcescens Db1121 (LC=4.4 ?M), Serratia marcescens Strain 122 (LC=3.2 ?M), Pseudomonas aeruginosa OT97 (LC=4.8 ?M), Xenorhabdus nematophilus Xn21 (LC=1.4 ?M).##[Ref.29925795]Gram-negative bacterium:Escherichia coli CVCC 245 (MIC=4.2 0.35g/mL);##Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC=198 10.1g/mL),L. mono. CVCC 1599 (MIC=64.5 3.20g/mL)" [Ref.29925795] 50% hemolysis at 169 8.20 g/ml against sheep red blood cells. Linear Free Amidation Free L [Ref.29925795]No cytotoxicity information found##[Ref.7140755]No cytotoxicity information found Not found 7140755##29925795 Eur J Biochem. 1982 Sep;127(1):207-217.##Molecules. 2018 Jun 20;23(6):1491. "Hultmark D, Engstr?m A, Bennich H, Kapur R, Boman HG.##Wei X, Wu R, Zhang L, Ahmad B, Si D, Zhang R." "Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae.##Expression, Purification, and Characterization of a Novel Hybrid Peptide with Potent Antibacterial Activity" DRAMP01391 GCSRWIIGIHGQICRD 16 "Odorranain-U1 (OdU1; Frogs, amphibians, animals)" A6MBS4 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-U1 adopts 60.2% None Function: Odorranain-U1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC>100 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=75.00 g/ml), Bacillus subtilis (MIC=9.37 g/ml).##Yeast: Candida albicans (MIC=9.37 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01832 FLPGLLAGLL 10 "Temporin-Eca (Frogs, amphibians, animals)" C0HJB9 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Euphlyctis cyanophlyctis (Skittering frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml, respectively. Tissue specificity: Expressed by the skin glands." "[Swiss_Prot Entry C0HJB9]Gram-negative bacteria: Escherichia coli HP101BA (MIC=12.3 ?M), Klebsiella pneumoniae PTCC1388 (MIC=9.8 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=8.3 ?M), Staphylococcus aureus PTCC1431 (MIC=10.6 ?M)." [Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Int. J. Pept. Res. Ther. 2012;18:107-115. "Asoodeh A, Ghorani-Azam A, Chamani JK." Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis. DRAMP01833 RAGLKFPVGRVHRLLR 16 "Buforin-EC (Frogs, amphibians, animals)" C0HJB7 Belongs to the histone H2A family Not found Euphlyctis cyanophlyctis (Skittering frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml, respectively. Tissue specificity: Expressed by the skin glands." "[Swiss_Prot Entry C0HJB7]Gram-negative bacteria: Escherichia coli HP101BA (MIC=9.6 ?M), Klebsiella pneumoniae PTCC1388 (MIC=10.6 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=6.0 ?M), Staphylococcus aureus PTCC1431 (MIC=8.1 ?M)." [Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Int. J. Pept. Res. Ther. 2012;18:107-115. "Asoodeh A, Ghorani-Azam A, Chamani JK." Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis. DRAMP01834 FLNALKNFAKTAGKRLKSLLN 21 "Cyanophlyctin (Frogs, amphibians, animals)" C0HJB8 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Euphlyctis cyanophlyctis (Skittering frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml. Tissue specificity: Expressed by the skin glands." "[Swiss_Prot Entry C0HJB8]Gram-negative bacteria: Escherichia coli HP101BA (MIC=6.4 ?M), Klebsiella pneumoniae PTCC1388 (MIC=7.3 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=4.7 ?M), Staphylococcus aureus PTCC1431 (MIC=5.3 ?M)." [Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Int. J. Pept. Res. Ther. 2012;18:107-115. "oodeh A, Ghorani-Azam A, Chamani JK." Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis. DRAMP01840 GFRDVLKGAAKAFVKTVAGHIAN 23 "Ascaphin-1 (Frogs, amphibians, animals)" P0CJ25 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: Asparagine amide at position 23. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M). [Ref.15207717]HC50>200 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01842 GFRDVLKGAAKAFVKTVAGHIANI 24 "Ascaphin-3 (Frogs, amphibians, animals)" P0CJ27 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M). [Ref.15207717]HC50>200 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01844 GIKDWIKGAAKKLIKTVASNIANQ 24 "Ascaphin-5 (Frogs, amphibians, animals)" P0CJ29 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. "[Ref.15207717]Gram-negative bacteria: Escherichia coli (MIC=6 ?M), Pseudomonas aeruginosa (MIC=13 ?M), Enterobacter cloacae (MIC=6 ?M), Klebsiella pneumoniae (MIC=13 ?M), Proteus mirabilis (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?M), Staphylococcus epidermidis (MIC=13 ?M), Enterococcus faecalis (MIC>100 ?M), Streptococcus Group B (MIC=6 ?M);##Yeast: Candida albicans (MIC=100 ?M)." [Ref.15207717]Not found Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01846 GFKDWIKGAAKKLIKTVASSIANQ 24 "Ascaphin-7 (Frogs, amphibians, animals)" P0CJ31 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M). [Ref.15207717]HC50>200 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01847 GFKDLLKGAAKALVKTVLF 19 "Ascaphin-8 (Frogs, amphibians, animals)" P0CJ32 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Not found Not found None Function: Antimicrobial peptide that shows similar potency against Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: Phenylalanine amide at position 19. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M). [Ref.15207717]HC50=50 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01849 DSMGAVKLAKLLIDKMKCEVTKAC 24 "Jindongenin-1a (JD1a; Frogs, amphibians, animals)" G3ETQ2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops jingdongensis (Chinese torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Also displays antifungal activity against C. albicans ATCC 2002. Has hemolytic activity, low cytotoxicity and low antioxidant activity." "[Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=17 ?M), Enterococcus faecalis ATCC29212 (MIC=60 ?M), Staphylococcus aureus (IS 10#)(MIC=40 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=10 ?M), Enterobacter cloacae ATCC13047 (MIC=40 ?M), Klebsiella pneumoniae ATCC700603 (MIC=15 ?M), Bacillus pyocyaneus CMCCB1010 (MIC=17 ?M), Pseudomonas aeruginosa ATCC27853 (MIC=23 ?M), Bacillus dysenteriae (MIC=40 ?M);##Yeast: Candida albicans ATCC2002 (MIC=60 ?M)." [Ref.21816202] IC50=150 M against washed human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.21816202] Cytotoxicity: the K562 (IC50=46M)and HT29 mammalian cell lines(IC50=40M). Not found 21816202 Biochimie. 2012 Feb;94(2):328-334. "Chen Z, Yang X, Liu Z, Zeng L, Lee W, Zhang Y." "Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis." DRAMP01869 FFPIIAGMAAKLIPSLFCKITKKC 24 "Brevinin-1SPa (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M);##Yeast: Candida albicans (MIC=7 ?M). [Ref.15556063]HC50=7 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01870 FLPIIAGMAAKVICAITKKC 20 "Brevinin-1SPb (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes (HC50=6 ?M). [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=13 ?M);##Yeast: Candida albicans (MIC=25 ?M). [Ref.15556063]HC50=25 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01872 FFPIIAGMAAKVICAITKKC 20 "Brevinin-1SPd (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 ?M);##Yeast: Candida albicans (MIC=8 ?M). [Ref.15556063]HC50=8 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01873 GIWDTIKSMGKVFAGKILQNL 21 "Brevinin-2-related peptide (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. Sequence similarity: This peptide shows limited structural similarity with the N-terminal region of brevinin-2 peptides previously isolated from R. temporaria skin but lacks the C-terminal cyclic heptapeptide domain associated with this family. PTM: C-terminal amidation." [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M);##Yeast: Candida albicans (MIC=70 ?M). [Ref.15556063]HC50=70 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP04213 KKLFKKILKYL 11 BP100 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Alpha helix The peptide adopted with positively charged residues on one face and the hydrophobic residues on the opposite face of the helix None Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Has hemolytic activity. [Ref.29750913] Gram-negative bacteria:Escherichia coli(ATCC 25922)(MIC=2 M);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=2M);Bacillus subtilis(PY79)(MIC=2M) [Ref.29750913] 10% hemolysis at 64M against human red blood cell Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 29750913 Biochim Biophys Acta. 2018 Aug;1860(8):1502-1516. "Carretero GPB, Saraiva GKV, Cauz ACG, Rodrigues MA, Kiyota S, Riske KA, Dos Santos AA, Pinatto-Botelho MF, Bemquerer MP, Gueiros-Filho FJ, Chaimovich H, Schreier S, Cuccovia IM." "Synthesis, biophysical and functional studies of two BP100 analogues modified by a hydrophobic chain and a cyclic peptide." DRAMP03571 LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 37 LL-37 "P49913,Q71SN9" Belongs to the cathelicidin family CAMP Human lysosomes of polymorphonuclear leukocytes "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Alpha helix The peptide adopted 1 helices and 30 residues and a curved amphipathic helix-bend-helix motif spanning residues 2-31 followed by a disordered C-terminal tail. The helical bend is located between residues Gly-14 and Glu-16. 2K6O resolved by NMR Function:Antibacterial activity against the Gram-positive and Gram-negative bacteria. Has hemolytic activity. [Ref.29859288] Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=25??0 g/ml);ESBL-producing Escherichia coli(MIC=33.3??14.4g/ml);NDM-1 producing Acinetobacter baumannii(MIC=20.8??7.2 g/ml);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=133.3??57.7g/ml);##Fungi:Candida albicans (ATCC 90028)(MIC>400g/ml) [Ref.29859288] 2.9??0.7% Hemolysis at 500g/ml against human red blood cell Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 29859288 Gene. 2018 May 30. pii: S0378-1119(18)30617-6. "Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S." Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. DRAMP01748 FFPIVGKRLYGLL 13 "Temporin-AJ8 (Frogs, amphibians, animals)" K7Z903 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops jingdongensis (torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Shows antimicrobial abilities against microorganisms including Gram-negative and Gram-positive bacteria, and fungi. Has hemolytic activity." "[Ref.22828809] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=70 g/ml), B. dysenteriae(MIC=18.75 g/ml) ;## Gram-positive bacteria: Staphylococcus aureus ATCC 2592(MIC=4.7 g/ml), Bacillus subtilis ATCC 6633(MIC=9.38 g/ml);## Yeast: Candida albicans ATCC 2002(MIC=37.5 g/ml)." "[Ref.22828809] 1.79% hemolysis at 25g/ml, 5.22% hemolysis at 50g/ml, 7.92% hemolysis at 100g/ml, 10.85% hemolysis at 200g/ml against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22828809 Amino Acids. 2012 Jul 25. "He X, Yang S, Wei L, Liu R, Lai R, Rong M." "Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis." DRAMP01879 GAFGDLLKGVAKEAGMKLLNMAQCKLSGKC 30 "Brevinin-2LTa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2 ?M), Bacillus licheniformis X39 (MIC=8 ?M), Staphylococcus carnosus KHS (MIC=2 ?M), Rhodococcus rhodochrous X15 (MIC=0.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=32.5 ?M), Serratia rubidaea X01 (MIC=130 ?M), Pseudomonas aeruginosa 1.50 (MIC=65 ?M), Psychrobacter faecalis X29 (MIC=0.5 ?M)." [Ref.22426384] LD50=520 M against human erythrocytes Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01880 SILDKIKNVALGVARGAGTGILKALLCKLDKSC 33 "Brevinin-2LTb (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.8 ?M), Bacillus licheniformis X39 (MIC=3.8 ?M), Staphylococcus carnosus KHS (MIC=1.9 ?M), Rhodococcus rhodochrous X15 (MIC=1.9 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 ?M), Serratia rubidaea X01 (MIC=60 ?M), Pseudomonas aeruginosa 1.50 (MIC=30 ?M), Psychrobacter faecalis X29 (MIC=1.9 ?M)." [Ref.22426384] LD50=480 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01881 GVLDTFKDVAIGVAKGAGTGVLKALLCKLDKSC 33 "Brevinin-2LTc (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=60 ?M), Rhodococcus rhodochrous X15 (MIC=30 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=15 ?M)." [Ref.22426384] LD50>480 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01885 FFGPLIKIATGVLPNLICKALGKC 24 "Brevinin-1TEa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana temporalis (Indian bronzed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria. "Gram-negative bacteria: E. coli (NCLM 2064) (MIC=30 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=150 ?g/ml), V. cholerae (PL 91) (MIC=150 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC=100 ?g/ml), S. aureus (ATCC25923) (MIC>150 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21412958 J Pept Sci. 2011 May;17(5):342-347. "Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S." Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae). DRAMP01886 GIGSMLLGLAKNVGMSLLNKAQCKISGKC 29 "Brevinin-2TEa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana temporalis (Indian bronzed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria. "Gram-negative bacteria: E. coli (NCLM 2064) (MIC=40 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=100 ?g/ml), V. cholerae (PL 91) (MIC=150 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC>150 ?g/ml), S. aureus (ATCC25923) (MIC>150 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21412958 J Pept Sci. 2011 May;17(5):342-347. "Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S." Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae). DRAMP01887 GFMGDTLKGIARNAALALMNAAQCKLSGKC 30 "Brevinin-2TEb (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana temporalis (Indian bronzed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria. "Gram-negative bacteria: E. coli (NCLM 2064) (MIC=20 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=40 ?g/ml), V. cholerae (PL 91) (MIC=60 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC=150 ?g/ml), S. aureus (ATCC25923) (MIC=40 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21412958 J Pept Sci. 2011 May;17(5):342-347. "Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S." Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae). DRAMP01888 FFPTIAGLTKLFCAITKKC 19 "Brevinin-1CHc (Frogs, amphibians, animals)" No entry found Not found Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: E. coli (MIC=80 ?M);##Gram-positive bacterium: S. aureus (MIC=20 ?M).##Yeast: C. albicans (MIC=20 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys13 and Cys19) Disulfide bond between Cys13 and Cys19. L No cytotoxicity information found Not found 21262304 Peptides. 2011 Apr;32(4):664-669. "Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01889 GIGSILGVIAKGLPTLISWIKNR 23 "Brevinin-1TOa (Frogs, amphibians, animals)" No entry found Not found Not found Rana tagoi okiensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: E. coli (MIC=20 ?M);##Gram-positive bacterium: S. aureus (MIC=5 ?M).##Yeast: C. albicans (MIC=20 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19799928 Toxicon. 2010 Feb-Mar;55(2-3):430-435. "Conlon JM, Coquet L, Jouenne T, Leprince J, Vaudry H, Iwamuro S." Evidence from the primary structures of dermal antimicrobial peptides that Rana tagoi okiensis and Rana tagoi tagoi (Ranidae) are not conspecific subspecies. DRAMP01890 FLGAIAGVAAKFLPKVFCFITKKC 24 "Brevinin-1VLa (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Brevinin-1VLa showes particularly high growth-inhibitory potency (MIC < or =3 microM) against a Gram-positive microorganism Staphylococcus aureus and the opportunistic yeast pathogen Candida albicans and potent cytolytic activity (LC(50)< or =8 microM) against both human erythrocytes and HepG2 hepatoma-derived cells. The peptide ia also active against a Gram-negative microorganism Escherichia coli (MIC< or =50 microM). Gram-negative bacterium: E. coli (MIC=25 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=8 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01891 FLPVIASVAAKVLPKVFCFITKKC 24 "Brevinin-1VLc (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Brevinin-1VLc showes particularly high growth-inhibitory potency (MIC < or =3 microM) against a Gram-positive microorganism Staphylococcus aureus and the opportunistic yeast pathogen Candida albicans and potent cytolytic activity (LC(50)< or =8 microM) against both human erythrocytes and HepG2 hepatoma-derived cells. The peptide ia also active against a Gram-negative microorganism Escherichia coli (MIC< or =50 microM). Gram-negative bacterium: E. coli (MIC=50 ?M);##Gram-positive bacterium: S. aureus (MIC=1.5 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=7 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01892 FLPLIAGVAANFLPKIFCLISKKC 24 "Brevinin-1VLd (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells" Gram-negative bacterium: E. coli (MIC>100 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=5 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=6mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01893 FLPLIAGVAASILPKIFCFITKKC 24 "Brevinin-1VLe (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells" Gram-negative bacterium: E. coli (MIC>100 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=5 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=7mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01896 FLSTALKVAANVVPTLFCKITKKC 24 "Brevinin-1CG1 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=9 ?M), Bacillus licheniformis X39 (IS) (MIC=75 ?M);##Gram-negative bacterium: Escherichia coli (ATCC 25922) (MIC=150 ?M).##Fungi: Slime mold 090223 (IS) (MIC=75 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01897 FLPIVAGLAANFLPKIVCKITKKC 24 "Brevinin-1CG2 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=9 ?M), Bacillus licheniformis X39 (IS) (MIC=75 ?M), Enterococcus faecalis 981 (MIC=19 ?M), Staphylococcus carnosus KHS (IS) (MIC=9 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=19 ?M), Serratia rubidaea X01 (IS) (MIC=19 ?M).##Fungi: Slime mold 090223 (IS) (MIC=4.5 ?M), Candida albicans (ATCC 10231) (MIC=150 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01898 FLSTLLNVASNVVPTLICKITKKC 24 "Brevinin-1CG3 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Primarily active against Gram-positive bacteria. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea. "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=2.3 ?M), Bacillus licheniformis X39 (IS) (MIC=9 ?M), Enterococcus faecalis 981 (MIC=75 ?M), Staphylococcus carnosus KHS (IS) (MIC=19 ?M), Staphylococcus aureus (ATCC 25923) (MIC=19 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=4.5 ?M), Serratia rubidaea X01 (IS) (MIC=9 ?M).##Fungi: Slime mold 090223 (IS) (MIC=9 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01899 FLSTLLNVASKVVPTLFCKITKKC 24 "Brevinin-1CG4 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=2.3 ?M), Bacillus licheniformis X39 (IS) (MIC=9 ?M), Enterococcus faecalis 981 (MIC=9 ?M), Staphylococcus carnosus KHS (IS) (MIC=9 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli (ATCC 25922) (MIC=150 ?M), Pseudomonas aeruginosa 11053 (IS) (MIC=75 ?M), Psychrobacter faecalis X29 (IS) (MIC=9 ?M), Serratia rubidaea X01 (IS) (MIC=9 ?M).##Fungi: Slime mold 090223 (IS) (MIC=9 ?M), Candida albicans (ATCC 10231) (MIC=150 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01900 FLPMLAGLAANFLPKIVCKITKKC 24 "Brevinin-1CG5 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Primarily active against Gram-positive bacteria, escecially R. rhodochrous. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea." "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=0.6 ?M), Bacillus licheniformis X39 (IS) (MIC=2.3 ?M), Enterococcus faecalis 981 (MIC=9 ?M), Staphylococcus carnosus KHS (IS) (MIC=1.2 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=75 ?M), Pseudomonas aeruginosa (CGMCC 1.50) (MIC=75 ?M), Pseudomonas aeruginosa 11053 (IS) (MIC=75 ?M), Klebsiella pneumoniae 08040724 (IS) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=9 ?M), Serratia rubidaea X01 (IS) (MIC=4.6 ?M).##Fungi: Slime mold 090223 (IS) (MIC=4.5 ?M), Candida albicans (ATCC 10231) (MIC=437.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01910 GVITDALKGAAKTVAAELLRKAHCKLTNSC 30 "Brevinin-2GHb (AMP-2; Frogs, amphibians, animals)" A0AEI5 Belongs to the frog skin active peptide family (Brevinin subfamily) br2GHb Rana guentheri (Gunther's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: Problely contains one disulfide bond 24-30. " "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=16.5 ?g/ml), Bacillus subtilis ATCC 6633 (MIC>64 ?g/ml);##Gram-negative bacteria: Escherichia coli O111 (MIC=8.2 ?g/ml), Escherichia coli ATCC 25922 (MIC=8.2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 16979798 Peptides. 2006 Dec;27(12):3077-3084. "Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ." Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. DRAMP01911 SIWEGIKNAGKGFLVSILDKVRCKVAGGCNP 31 "Brevinin-2GHc (AMP-4; Frogs, amphibians, animals)" A0AEI6 Belongs to the frog skin active peptide family (Brevinin subfamily) br2GHc Rana guentheri (Gunther's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: Problely contains one disulfide bond 24-30. " "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=9.8 ?g/ml), Bacillus subtilis ATCC 6633 (MIC>64 ?g/ml);##Gram-negative bacteria: Escherichia coli O111 (MIC=19.6 ?g/ml), Escherichia coli ATCC 25922 (MIC=9.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 16979798 Peptides. 2006 Dec;27(12):3077-3084. "Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ." Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. DRAMP01913 FLPLLAGLAANFLPKIFCKITKKC 24 "Brevinin-1GRa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. " Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H. " "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami. " DRAMP01914 GLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC 33 "Brevinin-2GRa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M).##Yeast: Candida albicans (MIC>100 ?M). [Ref.16621155] LC50=140 M against human erythrocytes. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16621155##17272268 Peptides. 2006 Sep;27(9):2111-2117.##Mol Cell Proteomics. 2007 May;6(5):882-894. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H.##Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami.##Anti-infection peptidomics of amphibian skin." DRAMP01918 FLPLIAGLAANFLPKIFCAITKKC 24 "Brevinin-1PLb (Frogs, amphibians, animals)" A7WNV3 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity. Tissue specificity: Expressed by the skin glands." Gram-positive bacterium: Staphylococcus aureus (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli(MIC=26 ?M).##Yeast: Candida albicans (MIC=6 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17698247##11087945 Peptides. 2007 Aug;28(8):1605-1610.##Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Zhou M, Wang L, Owens DE, Chen T, Walker B, Shaw C.##Basir YJ, Knoop FC, Dulka J, Conlon JM." "Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step shotgun cloning.##Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01919 FLPVIAGVAAKFLPKIFCAITKKC 24 "Brevinin-1PLc (Frogs, amphibians, animals)" A7WNV4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli(MIC=7 ?M).##Yeast: Candida albicans (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17698247##11087945 Peptides. 2007 Aug;28(8):1605-1610.##Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Zhou M, Wang L, Owens DE, Chen T, Walker B, Shaw C.##Basir YJ, Knoop FC, Dulka J, Conlon JM." "Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step shotgun cloning.##Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01920 FLPILAGLAAKIVPKLFCLATKKC 24 "Brevinin-1CSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Brevinin-1CSa was strongly hemolytic against human erythrocytes. [Ref.17451843]Gram-negative bacterium: Escherichia coli (MIC=32 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M). [Ref.17451843] LD50=5 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 17451843 Peptides. 2007 Jun;28(6):1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP01922 GLFNVFKKVGKNVLKNVAGSLMDNLKCKVSGEC 33 "Brevinin-2SKb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sakuraii (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17174009 Peptides. 2007 Mar;28(3):505-514. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii. DRAMP01933 GIMDTLKNLAKTAGKGALQSLVKMASCKLSGQC 33 "Brevinin-2Ef (Frogs, amphibians, animals)" P40842 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity " [Swiss_Prot Entry P40842]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species [Ref.8163497]LC50>100 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8163497 J Biol Chem. 1994 Apr 22;269(16):11956-11961. "Simmaco M, Mignogna G, Barra D, Bossa F." Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. DRAMP01934 GILSTIKDFAIKAGKGAAKGLLEMASCKLSGQC 33 "Brevinin-2Ei (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01935 GIFLDKLKNFAKGVAQSLLNKASCKLSGQC 30 "Brevinin-2Ej (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli (MIC=2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01937 GLGSILGKILNVAGKVGKTIGKVADAVGNKE 31 "CPRF-Ea (caerulein precursor-related fragment; Frogs, amphibians, animals)" No entry found Not found Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli (MIC=4 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01938 GLGSFLKNAIKIAGKVGSTIGKVADAIGNKE 31 "CPRF-Eb (caerulein precursor-related fragment; Frogs, amphibians, animals)" No entry found Not found Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli (MIC=5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01939 GLGSFFKNAIKIAGKVGSTIGKVADAIGNKE 31 "CPRF-Ec (caerulein precursor-related fragment; Frogs, amphibians, animals)" No entry found Not found Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli (MIC=4 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01940 FLPIIAGVAAKVLPKLFCAITKKC 24 "Brevinin-1CHa (Frogs, amphibians, animals)" A7YJE2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None PTM: Contains disulfide bond. "Gram-negative bacteria: E. coli (MIC=10 ?M), K. pneumoniae (MIC=40 ?M), P. aeruginosa (MIC=20 ?M);##Gram-positive bacterium: S. aureus (MIC=2.5 ?M).##Yeast: C. albicans (MIC=2.5 ?M).(Ref.2)" [Ref.21262304] LC50=5 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 17938991##21262304 J Mol Evol. 2007 Nov;65(5):605-615.##Peptides. 2011 Apr;32(4):664-669. "Tennessen JA, Blouin MS.##Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.##Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01941 FLPVIAGLAAKVLPKLFCAITKKC 24 "Brevinin-1CHb (Frogs, amphibians, animals)" A7YJE4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None PTM: Contains disulfide bond. "Gram-negative bacteria: E. coli (MIC=10 ?M), K. pneumoniae (MIC=40 ?M), P. aeruginosa (MIC=10 ?M);##Gram-positive bacterium: S. aureus (MIC=2.5 ?M).##Yeast: C. albicans (MIC=2.5 ?M).(Ref.2)" [Ref.21262304] LC50=5 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 17938991##21262304 J Mol Evol. 2007 Nov;65(5):605-615.##Peptides. 2011 Apr;32(4):664-669. "Tennessen JA, Blouin MS.##Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.##Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01942 FLPAIVGAAGQFLPKIFCAISKKC 24 "Brevinin-1Sa (Frogs, amphibians, animals)" P82904 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sphenocephala (Southern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=55 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10604597 J Pept Res. 1999 Dec;54(6):522-527. "Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC." "Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala." DRAMP01943 FLPAIVGAAGKFLPKIFCAISKKC 24 "Brevinin-1Sb (Frogs, amphibians, animals)" P82905 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sphenocephala (Southern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=17 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10604597 J Pept Res. 1999 Dec;54(6):522-527. "Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC." "Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala." DRAMP01944 FFPIVAGVAGQVLKKIYCTISKKC 24 "Brevinin-1Sc (Frogs, amphibians, animals)" P82906 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sphenocephala (Southern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=14 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10604597 J Pept Res. 1999 Dec;54(6):522-527. "Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC." "Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala." DRAMP01949 FLPAVLRVAAKIVPTVFCAISKKC 24 "Brevinin-1HSa (Frogs, amphibians, animals)" P0C8S7 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana hosii (Hose's rock frog) (Odorrana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 18-24." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=24 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01950 FLPAVLRVAAQVVPTVFCAISKKC 24 "Brevinin-1HSb (Brevinin-1JDb; Frogs, amphibians, animals)" P0C8S8 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana hosii (Hose's rock frog) (Odorrana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 18-24." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC>48 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01951 FMGGLIKAATKIVPAAYCAITKKC 24 "Brevinin-1PTa (Frogs, amphibians, animals)" P0C8T1 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 18-24." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=24 ?M). Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01953 GLLDSLKNLAINAAKGAGQSVLNTLSCKLSKTC 33 "Brevinin-2HSa (Frogs, amphibians, animals)" P0C8S9 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hosii (Hose's rock frog) (Rana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=36 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01955 GAIKDALKGAAKTVAVELLKKAQCKLEKTC 30 "Brevinin-2PTa (Frogs, amphibians, animals)" P0C8T3 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 24-30." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01956 GFKGAFKNVMFGIAKSAGKSALNALACKIDKSC 33 "Brevinin-2PTb (Frogs, amphibians, animals)" P0C8T4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=9 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01957 GLLDSFKNAMIGIAKSAGKTALNKIACKIDKTC 33 "Brevinin-2PTc (Frogs, amphibians, animals)" P0C8T5 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>72 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01959 GFLDSFKNAMIGVAKSVGKTALSTLACKIDKSC 33 "Brevinin-2PTe (Frogs, amphibians, animals)" P0C8T7 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=36 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01963 FLPAIVGAAAKFLPKIFCAISKKC 24 "Brevinin-1BLa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates blairi (plains leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus" [Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=1.5 M);##Gram-negative bacteria : Escherichia coli(MIC=25 M);##Fungi : Candida albicans(MIC=6 M) [Ref.19254736] LC50=14 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01965 FLPIIAGIAAKFLPKIFCTISKKC 24 "Brevinin-1BLc (Frogs, amphibians, animals)" B6CPR0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates blairi (leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans [Ref.19254736]Gram-negative bacterium:?Escherichia coli (MIC=25 ?M);##Gram-positive bacterium:?Staphylococcus aureus (MIC=1.5 ?M);##Yeast:?Candida albicans (MIC=3 ?M);##Cancer cells HepG2:?(LC50=6 ?M).. [Ref.19254736] LC50=9 M against human red blood cells.##[Ref.14531844]Non-hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01968 FLPIIAGAAAKVVEKIFCAISKKC 24 "Brevinin-1Yc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates yavapaiensis (North American leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans [Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=6 M);##Gram-negative bacteria : Escherichia coli(MIC=100 M);##Fungi : Candida albicans(MIC=6 M)Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).##Yeast: Candida albicans (MIC=6 ?M).##cancer cells HepG2 (LC50=14 ?M). [Ref.19254736] LC50=13 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01969 FLGSLIGAAIPAIKQLLGLKK 21 "Brevinin-1Ja (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana japonica (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None It can produced cell death of mammalian COS7 cells (LD50=28 ?M). Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=119 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18558801 Zoolog Sci 2008; 25: 487-491. "Koyama T, Iwamuro S." "Molecular cloning of a cDNA encoding atypical antimicrobial and cytotoxic brevinin-1Ja from the skin of the Japanese brown frog, Rana japonica." DRAMP01970 FLPFLLSALPKVFCFFSKKC 20 "Brevinin-1ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=32 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>43 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01971 FLPLLLSALPSFLCLVFKKC 20 "Brevinin-1ZHb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=33 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC>44 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>44 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01974 GIMRVFKGVLKTAGKSVAKNVAGSFLDRLKCKISGGC 37 "Brevinin-2ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=5 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01986 SLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC 33 "Brevinin-2HS2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Huia schmackeri (Chinese piebald odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: It shows poor hemolycity activity (LC50=300 uM). "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 ?M), Bacillus licheniformis X39 (MIC=39 ?M), Rhodococcus rhodochrous X15 (MIC=9.5 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 ?M).##Fungi: Slime mould 090223 (MIC=37.5 ?M), Candida albicans ATCC2002 (MIC=19 ?M)." LC50=300?M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18423796 Peptides. 2008 Aug;29(8):1456-1460. "Quan Z, Zhou M, Chen W, Chen T, Walker B, Shaw C." Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors. DRAMP01990 FMGSALRIAAKVLPAALCQIFKKC 24 "Brevinin-1LT1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii (Chinese broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity against rabbit red blood cells." "[Ref.19340924]Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 ?M), Bacillus subtilis (MIC=6.25 ?M);##Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 ?M);##Yeast: Candida albicans (MIC=50 ?M)." [Ref.19340924]LC50>200 ?g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19340924 Biochimie. 2009 Apr;91(4):540-547. "Wang H, Yan X, Yu H, Hu Y, Yu Z, Zheng H, Chen Z, Zhang Z, Liu J." "Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae)." DRAMP01994 SLLDTFKNLAVNAAKSAGVSVLNALSCKISRTC 33 "Brevinin-2ISa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. "Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ?M), S. aureus (MRSA) (MIC=100 ?M), Bacillus subtilis (MIC=12.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01995 SFLTTFKDLAIKAAKSAGQSVLSTLSCKLSNTC 33 "Brevinin-2ISb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), Bacillus subtilis (MIC=25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01996 SVLGTVKDLLIGAGKSAAQSVLTTLSCKLSNSC 33 "Brevinin-2ISc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP02001 FLPLIASLAANFVPKIFCKITKKC 24 "Brevinin-1HN1 (Frogs, amphibians, animals)" E7EKC4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P. faecalis. Has hemolytic activity against human erythrocytes (LC50=75 ?M). Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond." "[Ref.22450466]Gram-positive bacteria: Enterococcus faecium 091299 (MIC=19 ?M), Enterococcus faecalis 981 (MIC=19 ?M), Staphylococcus aureus ATCC2592 (MIC=1.2 ?M), Staphylococcus carnosus KHS (MIC=4.8 ?M), Bacillus licheniformis X39 (MIC=2.4 ?M), Rhodococcus rhodochrous X15 (MIC=1.2 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=150 ?M), Psychrobacter faecalis X29 (MIC=4.8 ?M);##Fungi: Slime mould 090223 (MIC=1.2 ?M), Candida albicans ATCC2002 (MIC=2.4 ?M)." [Ref.22450466] LC50=75 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP02004 FLPLIASVAANLVPKIFCKITKKC 24 "Brevinin-1V (Frogs, amphibians, animals)" "Q2UXV8, E7EKC5" Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana versabilis (Chinese bamboo leaf odorous frog) (Rana versabilis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P. faecalis. Has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond." "[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 ?M), Bacillus licheniformis X39 (MIC=37.5 ?M), Rhodococcus rhodochrous X15 (MIC=9.5 ?M), Enterococcus faecium 091299 (MIC=19 ?M), E. faecalis 981 (MIC=19 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 ?M);##Fungi: Slime mould 090223 (MIC=1.2 ?M), Candida albicans ATCC2002 (MIC=19-37.5 ?M)." [Ref.22450466] LC50=75 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 16139929##22450466 Peptides. 2006 Jan;27(1):42-48.##Peptides. 2012 Jun;35(2):285-290. "Chen T, Li L, Zhou M, Rao P, Walker B, Shaw C.##Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Amphibian skin peptides and their corresponding cDNAs from single lyophilized secretion samples: identification of novel brevinins from three species of Chinese frogs.##Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP02006 GIWDTLKNVGKAVLGKVLENV 21 "Brevinin-2Va (Frogs, amphibians, animals)" No entry found Not found Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15996769 Regul Pept. 2005 Nov;131(1-3):38-45. "Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR." "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP02009 FLPVLAGIAAKVVPALFCKITKKC 24 "Brevinin-1 (Frogs, amphibians, animals)" P32423 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana brevipoda porsa (Japanese frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity." [Ref.1449472]Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=34 ?g/ml). [Ref.1449472] high hemolytic activity Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 1449472 Biochem Biophys Res Commun. 1992 Nov 30;189(1):184-190. "Morikawa N, Hagiwara K, Nakajima T." "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa." DRAMP02010 GLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC 33 "Brevinin-2 (Frogs, amphibians, animals)" P32424 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana brevipoda porsa (Japanese frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity." [Ref.1449472]Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=4 ?g/ml). [Ref.1449472] high hemolytic activity Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 1449472 Biochem Biophys Res Commun. 1992 Nov 30;189(1):184-190. "Morikawa N, Hagiwara K, Nakajima T." "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa." DRAMP02019 GLFDVVKGVLKGAGKNVAGSLLEQLKCKLSGGC 33 "Brevinin-2DYb (Frogs, amphibians, animals)" P0C5X2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus (MIC=30 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 17688900 Toxicon. 2007 Nov;50(6):746-756. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S." "Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii." DRAMP02023 GIFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC 33 "Brevinin-2DYd (Frogs, amphibians, animals)" P0C5X4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15 ?M).##NOTE: mixture of Brevinin-2DYc/2DYd No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 17688900 Toxicon. 2007 Nov;50(6):746-756. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S." "Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii." DRAMP02025 GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKISGGC 37 "Brevinin-2DYe (Brevinin-2CDYa; Frogs, amphibians, animals)" P0C5X5 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Active against the Gram-positive bacteria: S. aureus and Gram-negative bacteria E. coli. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 31-37. Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 17688900##17698251 Toxicon. 2007 Nov;50(6):746-756.##Peptides. 2007 Aug;28(8):1532-1539. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S.##Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." "Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii.##Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii." DRAMP02026 LLSLALAALPKLFCLIFKKC 20 "Brevinin-1CDYa (Frogs, amphibians, animals)" B3VZU0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has low activity against the Gram-positive bacteria: S. aureus and Gram-negative bacteria E. coli. Has hemolytic activity against human erythrocytes (HC50=125 ?M). Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 14-20." [Swiss_Prot Entry B3VZU0]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25 ?M) [Ref.19539775]HC50=125 M against human red blood cells Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 19539775 Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178. "Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH." "Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii." DRAMP02031 ILPLLLGKVVCAITKKC 17 "Brevinin-1Da (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dalmatina (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Sequence alignment suggests that the peptide is derived from brevinin-1 by multiple residue deletions (D for ""dalmatina"" and 'a' to denote the first isoform identified). " Gram-positive bacterium: Staphylococcus aureus (MIC=7 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys11 and Cys17) Disulfide bond between Cys11 and Cys17. L No cytotoxicity information found Not found 15050930 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Feb;137(2):191-196. "Conlon JM, Seidel B, Nielsen PF." An atypical member of the brevinin-1 family of antimicrobial peptides isolated from the skin of the European frog Rana dalmatina. DRAMP02032 FLGSIVGALASALPSLISKIRN 22 "Brevinin-1TSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tsushimensis (Tsushima brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, but hemolytic activity against human erythrocytes." "[Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Klebsiella pneumoniae KK3 9904 (MIC>100 ?M), Enterobacter cloacae HNTCC 53001 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=50 ?M), Proteus mirabilis ATCC 25933 (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=25 ?M), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 ?M), Staphylococcus epidermidis RP62A (MIC=12.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=50 ?M), Streptococcus group B HNTCC 80130 (MIC=50 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=50 ?M)" [Ref.16413829]LD50=12 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16413829 Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. "Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. DRAMP02033 GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC 33 "Brevinin-2TSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tsushimensis (Tsushima brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, but relatively low hemolytic activity against human erythrocytes." "[Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Klebsiella pneumoniae KK3 9904 (MIC=6 ?M), Enterobacter cloacae HNTCC 53001 (MIC=6 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=6 ?M), Proteus mirabilis ATCC 25933 (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=12.5 ?M), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 ?M), Staphylococcus epidermidis RP62A (MIC=12.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=25 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=100 ?M)." [Ref.16413829] LD50=100 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16413829 Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. "Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. DRAMP02034 FLPILAGLAAKLVPKVFCSITKKC 24 "Brevinin-1AUa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana aurora aurora (Northern red-legged frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and also shows hemolytic. " "[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=13 ?M), Pseudomonas aeruginosa (MIC=25 ?M), Enterobacter cloacae (MIC=13 ?M), Klebsiella pneumoniae (MIC=50 ?M), Proteus mirabilis (MIC>50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Staphylococcus epidermidis (MIC=6 ?M), Enterococcus faecalis (MIC=13 ?M), Streptococcus Group B (MIC=13 ?M);##Yeast: Candida albicans (MIC>40 ?M)." [Ref.15325526] HC50=5 M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 15325526 Dev Comp Immunol. 2005;29(1):83-90. "Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T." Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. DRAMP02035 FLPILAGLAANILPKVFCSITKKC 24 "Brevinin-1AUb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana aurora aurora (Northern red-legged frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and also shows hemolytic activity. " "[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=25 ?M), Pseudomonas aeruginosa (MIC=25 ?M), Enterobacter cloacae (MIC=25 ?M), Klebsiella pneumoniae (MIC>50 ?M), Proteus mirabilis (MIC>50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Staphylococcus epidermidis (MIC=6 ?M), Enterococcus faecalis (MIC=6 ?M), Streptococcus Group B (MIC=13 ?M);##Yeast: Candida albicans (MIC=3 ?M)." [Ref.15325526] HC50=7 M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 15325526 Dev Comp Immunol. 2005;29(1):83-90. "Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T." Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. DRAMP02036 GAFGNFLKGVAKKAGLKILSIAQCKLSGTC 30 "Brevinin-2-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Brevinin-2-RN1 and -RN2 could induce 17 and 21% Rabbit red blood cell hemolysis, respectively." "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.10 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=3.10 ?g/ml), Bacillus subtilis (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=6.25 ?g/ml)." [Ref.21171145] It has 17% hemolysis at 100 ?g/ml against rabbit red blood cell Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 21171145 J Pept Sci. 2011 Jan;17(1):68-72. "Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R." "Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata." DRAMP02037 GAFGNFLKGVAKKAGLKILSIAQCKLFGTC 30 "Brevinin-2-RN2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Brevinin-2-RN1 and -RN2 could induce 17 and 21% Rabbit red blood cell hemolysis, respectively." "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=6.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 ?g/ml), Bacillus subtilis (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=50 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=12.5 ?g/ml). Yeast: Candida albicans ATCC2002 (MIC=3.1 ?g/m)." [Ref.21171145] It has 21% hemolysis at 100 ?g/ml against rabbit red blood cell Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 21171145 J Pept Sci. 2011 Jan;17(1):68-72. "Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R." "Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata." DRAMP02038 VIVFVASVAAEMMQHVYCAASKKC 24 "Brevinin-1-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 ?g/ml);##Gram-negative bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml), Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml).##Yeast: Candida albicans (MIC=24.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02040 FLPAVIRVAANVLPTAFCAISKKC 24 "Brevinin-1-OA12 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.2 ?g/ml).##Yeast: Candida albicans (MIC=3.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02041 LPFVAGVAAEMMQHVYCAASKKC 23 "Brevinin-1-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=42.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.6 ?g/ml).##Yeast: Candida albicans (MIC=10.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys17 and Cys23) Disulfide bond between Cys17 and Cys23. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02042 IDPFVAGVAAEMMQHVYCAASKKC 24 "Brevinin-1-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=9.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=18.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18.2 ?g/ml).##Yeast: Candida albicans (MIC=18.2 ?g/ml). " [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02043 INPFVAGVAAEMMQHVYCAASKKC 24 "Brevinin-1-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml).##Yeast: Candida albicans (MIC=8.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02044 ILPFVAGVAAEMMKHVYCAASKKC 24 "Brevinin-1-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None It differs from AP1824 only at position 14: Q vs. K. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.2 ?g/ml).##Yeast: Candida albicans (MIC=7.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02045 IIPFVAGVAAEMMEHVYCAASKKC 24 "Brevinin-1-OR6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None It differs from AP1827 at two positions: 2: I vs. L and 14: K vs. E. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.2 ?g/ml).##Yeast: Candida albicans (MIC=11.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02046 QLPFVAGVACEMCQCVYCAASKKC 24 "Brevinin-1-OR7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=5.7 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.4 ?g/ml).##Yeast: Candida albicans (MIC=11.4 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02047 ILPFVAGVAAEMMEHVYCAASKKC 24 "Brevinin-1-OR8 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=52.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=26.2 ?g/ml).##Yeast: Candida albicans (MIC=13.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02048 ILPFVAGVAAMEMEHVYCAASKKC 24 "Brevinin-1-OR9 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=9.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=9.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.9 ?g/ml).##Yeast: Candida albicans (MIC=9.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02049 FLPAVLLVATHVLPTVFCAITRKC 24 "Brevinin-1-OR10 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=27.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.8 ?g/ml).##Yeast: Candida albicans (MIC=6.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02050 LAFVAGVAAEMMQHVYCAASKKC 23 "Brevinin-1-OR11 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 ?g/ml).##Yeast: Candida albicans (MIC=12.4 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys17 and Cys23) Disulfide bond between Cys17 and Cys23. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02051 ILPFVAGVAAEMMQHVYCAASKKC 24 "Lividin-1 (Brevinin-1-OR2; Frogs, amphibians, animals)" Q2UXR4 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-1 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 ?g/ml).##Yeast: Candida albicans (MIC=5.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02052 SFLDTLKNLAISAAKGAGQSVLSTLSCKLSKTC 33 "Lividin-2 (Brevinin-2-OR8; Frogs, amphibians, animals)" Q2UXR3 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-2 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=13.1 ?g/ml).##Yeast: Candida albicans (MIC=13.1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02053 SVLGTVKDLLIGAGKSAAQSVLTALSCKLSNSC 33 "Lividin-3 (Brevinin-2-OR1; Frogs, amphibians, animals)" Q2UXR2 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-3 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11 ?g/ml).##Yeast: Candida albicans (MIC=11 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02054 GILDTFKNMALNAAKSAGVSVLNALSCKLSKTC 33 "Brevinin-2-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.1 ?g/ml).##Yeast: Candida albicans (MIC=6.0 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02055 GLLDTFKNMALNAAKSAGVSVLNALSCKLSKTC 33 "Brevinin-2-OA2 (Brevinin-2E-OG1; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Found in multiple species. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml).##Yeast: Candida albicans (MIC=6.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02056 GLLDTFKNMAINAAHGAGVSVLNALSCKLKKTC 33 "Brevinin-2-OA3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml).##Yeast: Candida albicans (MIC=3.2 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02057 GLLDTFKNLAINAAESAGVSVLNSLSCKLSKTC 33 "Brevinin-2-OA4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=10 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02058 GLLDGILNANFNAAKSAGTSVLNALSCKLSKTC 33 "Brevinin-2-OA5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=30.6 ?g/ml).##Yeast: Candida albicans (MIC=30.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02059 GVLATVKNLLIGTGDGAAQSVLKTLSCKLSNDC 33 "Brevinin-2-OA6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=44.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.4 ?g/ml).##Yeast: Candida albicans (MIC=11.2 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02060 GVLGTVKDLLIGAGKSAAQSTLKTLSCKISNDC 33 "Brevinin-2-OA7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 ?g/ml).##Yeast: Candida albicans (MIC=5.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02061 GVLATVKNLLNGTGDGAAQSVLKTLSCKLSNDC 33 "Brevinin-2-OA8 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.9 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.0 ?g/ml).##Yeast: Candida albicans (MIC=4.0 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02062 GLLDTIKNMALNAAKSAGVSVLNSLSCKLSKTC 33 "Brevinin-2-OR2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.0 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.1 ?g/ml).##Yeast: Candida albicans (MIC=12.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02063 GLIDTIKNMALNAAKSAGVSVLNTLSCKLSKTC 33 "Brevinin-2-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=41.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.6 ?g/ml).##Yeast: Candida albicans (MIC=10.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02064 SVLGTVKDLLIGAGKSAAQSVLTANSCKLSNSC 33 "Brevinin-2-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.9 ?g/ml).##Yeast: Candida albicans (MIC=11.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02065 SFLDTLKNLAISAAKGAGQSVLSTLSCKLSETC 33 "Brevinin-2-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml).##Fungi: Candida albicans (MIC=6.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02066 GLLDTIKNMALNAAKSAGVSVLNSLSCKDSKTC 33 "Brevinin-2-OR6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.8 ?g/ml).##Fungi: Candida albicans (MIC=11.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02067 GLLDTIKNMALNAAKSAGVSVLNTLSCKLSKTC 33 "Brevinin-2-OR7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml).##Fungi: Candida albicans (MIC=17.2 ?g/ml)" [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02068 SFLSTFKELAINAAKNAGQSILHTLSCKLDKTC 33 "Brevinin-2-OR9 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10.2 ?g/ml).##Fungi: Candida albicans (MIC=5.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02069 SFLSTFKELAINAAKNAGQSLLHTLSCKLDKTC 33 "Brevinin-2-OR10 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: It differs from AP1850 only at position 21: L vs. I, so they are predicted to have essentially identical structure and activity." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=7.9 ?g/ml).##Fungi: Candida albicans (MIC=15.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02070 SVMGTVKDLLIGAGKSAAQSVLKSLSCKISNDC 33 "Brevinin-2-OW1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.7 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=9.4 ?g/ml).##Fungi: Candida albicans (MIC=4.7 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02071 SVMGTVKDLLIGAGKSAAQSVLKSLSCKLSNDC 33 "Brevinin-2-OW2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.3 ?g/ml).##Fungi: Candida albicans (MIC=3.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02072 SVMGTVKDLLIGAGKSAAQSVLKALSCKLSKDC 33 "Brevinin-2-OW3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.0 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.5 ?g/ml).##Fungi: Candida albicans (MIC=10.5 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02073 FLPAVIRVAANVLPTVFCAISKKC 24 "Brevinin-1JDa (Frogs, amphibians, animals)" B3A0M4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bonds." "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), S. aureus (MRSA) (MIC=32 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=128 ?g/ml);##Fungi: Candida albicans (MIC=128 ?g/ml)." [Ref.22917879] It has 79.2 6.8% hemolytic activity at 128 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP02075 FLPAVLRVAAKVVPTVFCLISKKC 24 "Brevinin-1JDc (Frogs, amphibians, animals)" B3A0N0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bonds." "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), S. aureus (MRSA) (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=128 ?g/ml)." [Ref.22917879] It has 11.7 3.2% hemolytic activity at 64 g/mL and 88.4 4.2% hemolytic activity at 128 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP01746 FVQWFSKFLGRIL 13 "Temporin-L (Temporin-1Tl; temporin-Tl; TL; Frogs, amphibians, animals)" P57104 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic, Anti-cancer" Protein level Alpha helix Not found 6GS5 resolved by NMR. "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. PTM: Leucine amide at position 13. Tissue specificity: Expressed by the skin glands." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9022710 Eur J Biochem. 1996 Dec 15;242(3):788-792. "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D." "Temporins, antimicrobial peptides from the European red frog Rana temporaria." DRAMP02078 FLPVVAGLAAKVLPSIICAVTKKC 24 "Brevinin-1SY (Frogs, amphibians, animals)" P82871 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sylvatica (Wood frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=7 ?M);##Gram-negative bacterium: Escherichia coli (MIC=45 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11042268 FEBS Lett. 2000 Oct 20;483(2-3):135-138. "Matutte B, Storey KB, Knoop FC, Conlon JM." "Induction: of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli." DRAMP04238 FFHLHFHY 8 PL-101 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. "[Ref.12569105] Gram-negative bacterium: Escherichia coli (MEC=7 g/ml), Pseudomonas aeruginosa (MEC=10 g/ml).;##Gram-positive bacteria: Staphylococcus aureus (MEC=3 g/ml), MRSA (MEC=4 g/ml) at PH 6.5." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12569105 J Biol Chem. 2003 Apr 11;278(15):13546-53. "Tincu JA, Menzel LP, Azimov R, Sands J, Hong T, Waring AJ, Taylor SW, Lehrer RI." "Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes." DRAMP02778 AHCLAIGRK 9 "Defensin (Insects, animals)" O96049 Belongs to the invertebrate defensin family (Type 1 subfamil Not found Oryctes rhinoceros (Coconut rhinoceros beetle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None Function: Shows very strong activity against Staphylococcus aureus. Has no hemolytic activity. "[Ref.10561605] Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus aureus (MRSA) (MIC>50 ?g/ml);## Gram-negative bacteria: Escherichia coli (MIC=25 ?g/ml), Pseudomonas aeruginosa (MIC>50 ?g/ml)." [Ref.10561605] Had no hemolytic activity against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10561605 Eur. J. Biochem. 1999;266:616-623. "Ishibashi J, Yang J, Saido-Sakanaka H, Nakazawa H, Yamamoto M, Yamakawa M." "Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros." DRAMP02084 GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC 33 "Brevinin-2E (Frogs, amphibians, animals)" P32413 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity." "[Ref.8508915]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=2.0 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa ATCC 15692 (MIC>30 ?M)." [Ref.8163497]LC50>100 M against human red blood cells Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 8508915 FEBS Lett. 1993 Jun 14;324(2):159-161. "Simmaco M, Mignogna G, Barra D, Bossa F." Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. DRAMP02101 FLPLLAGVVANFLPQIICKIARKC 24 "Brevinin-1RTa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells (LD50=100.0 ?g/ml) in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=6.3 ?g/ml), Bacillus licheniformis X39 (MIC=25.0 ?g/ml), Rhodococcus rhodochrous X15 (MIC=3.1 ?g/ml);##Gram-negative bacteria: Serratia rubidaea X01 (MIC=NA ?g/ml), Pseudomonas aeruginosa 1.50 (MIC=NA ?g/ml), Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)." [Ref.22100518]LD50=100 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02102 FLGSLLGLVGKVVPTLFCKISKKC 24 "Brevinin-1RTb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells (LD50=200.0 ?g/ml) in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.1 ?g/ml), Bacillus licheniformis X39 (MIC=25.0 ?g/ml), Staphylococcus carnosus KHS (MIC=12.5 ?g/ml), Rhodococcus rhodochrous X15 (MIC=3.1 ?g/ml);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)" [Ref.22100518]LD50=200 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02104 GLMSTLKDFGKTAAKEIAQSLLSTASCKLAKTC 33 "Brevinin-2RTa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=12.5 ?g/ml), Bacillus licheniformis X39 (MIC=50.0 ?g/ml), Staphylococcus carnosus KHS (MIC=6.3 ?g/ml), Rhodococcus rhodochrous X15 (MIC=1.6 ?g/ml);##Gram-negative bacteria: Serratia rubidaea X01 (MIC=100.0 ?g/ml), Psychrobacter faecalis X29 (MIC=6.3 ?g/ml)." [Ref.22100518]LD50>400 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02105 GILDTLKEFGKTAAKGIAQSLLSTASCKLAKTC 33 "Brevinin-2RTb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and relatively low hemolytic activity (>400 ?g/ml) against rabbit red blood cells in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=50.0 ?g/ml), Bacillus licheniformis X39 (MIC=200.0 ?g/ml), Staphylococcus carnosus KHS (MIC=100.0 ?g/ml), Rhodococcus rhodochrous X15 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)." [Ref.22100518]LD50>400 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02114 AWLDKLKSLGKVVGKVALGVAQNYLNPQQ 29 "Raniseptin-1 (Rsp-1; Frogs, amphibians, animals)" P86037 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Hypsiboas raniceps (Chaco tree frog) (Hyla roeschmanni) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative as well as Gram-positive bacteria. And has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.18976634]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=10 ?M), Xanthomonas citri (MIC<2 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 29313 (MIC=20 ?M)." [Ref.18976634]20% hemolytic activity at 80 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18976634 Biochem Biophys Res Commun. 2008 Dec 26;377(4):1057-1061. "Magalh?es BS, Melo JA, Leite JR, Silva LP, Prates MV, Vinecky F, Barbosa EA, Verly RM, Mehta A, Nicoli JR, Bemquerer MP, Andrade AC, Bloch C Jr." Post-secretory events alter the peptide content of the skin secretion of Hypsiboas raniceps. DRAMP02125 IFGAILPLALGALKNLIK 18 "Hylin-a1 (Hy-a1; Frogs, amphibians, animals)" P85982 Not found Not found Hypsiboas albopunctatus (Spotted tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found 2N0O resolved by NMR. "Function: Has antibacterial activity against the Gram-positive bacteria and the Gram-negative bacteria. Has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.19056441]Gram-positive bacteria: Staphylococcus aureus ATCC 25926 (MIC=8 ?M), Enterococcus faecalis ATCC 29212 (MIC=16 ?M), Bacillus subtilis ATCC 19659 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=32 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=64 ?M);##Fungi: Candida albicans ATCC 90028 (MIC=16.7 ?M), C. krusei ATCC 6258 (MIC=16.7 ?M), C. parapsilosis ATCC 22019 (MIC=67 ?M), Cryptococcus neoformans ATCC 90012 (MIC=33.5 ?M)" [Ref.19056441]HC50=18 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19056441 Peptides. 2009 Feb;30(2):291-296. "Castro MS, Ferreira TC, Cilli EM, Crusca E Jr, Mendes-Giannini MJ, Sebben A, Ricart CA, Sousa MV, Fontes W." "Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus (spotted treefrog)." DRAMP02127 GLLGGLLGPLLGGGGGGGGGLL 22 "Leptoglycin (Gly-rich; Frogs, amphibians, animals)" P86267 Not found Not found Leptodactylus pentadactylus (Smokey jungle frog) (Rana pentadactyla) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial protein. Has antibacterial activity but not against Gram-positive bacteria Staphylococcus aureus, Micrococcus luteus and Enterococcus faecalis, yeasts Candida albicans and Candida tropicalis and dermatophytes fungi Microsporum canis and Trichophyton rubrum. No hemolytic activity was observed at the 2-200 microM range concentration. Tissue specificity: Expressed by the skin glands." "[Ref.19298834]Gram-negative bacteria: Escherichia coli ATCC 28922 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=8 ?M);##Fungi: Citrobacter freundii ATCC 8090 (MIC=75 ?M)" [Ref.19298834]Non-hemolytic activity was observed at 2-200 M concentration Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19298834 Toxicon. 2009 Jul;54(1):23-32. "Sousa JC, Berto RF, Gois EA, Fontenele-Cardi NC, Honrio JE Jr, Konno K, Richardson M, Rocha MF, Camargo AA, Pimenta DC, Cardi BA, Carvalho KM." Leptoglycin: a new glycine/leucine-rich antimicrobial peptide isolated from the skin secretion of the South American frog Leptodactylus pentadactylus (Leptodactylidae). DRAMP02129 FIKELLPHLSGIIDSVANAIK 21 "Kasstasin (Frogs, amphibians, animals)" G0LWV9 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Kassina maculata (African rhacophorid frog) (Hylambates maculatus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Peptide with potent vasoconstrictor properties. Has moderate antimicrobial activity. Not active against fungus C. albicans. Has hemolytic activity against horse erythrocytes. Tissue specificity: Expressed by the skin dorsal glands. Miscellaneous: Kasstasin is a derivation of Kassina, the taxon of origin, and the Ancient Greek word 'stasis' meaning 'stoppage of flow'." [Ref.21624426]Gram-positive bacterium: Staphylococcus aureus (MIC=55 ?M);##Gram-negative bacterium: Escherichia coli (MIC=110 ?M). [Ref.21624426]12.8% hemolytic activity at 125 M against defibrinated horse blood Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21624426 Biochimie. 2011 Sep;93(9):1537-1542. "Li X, Feng W, Zhou M, Ma C, Chen T, Zeller M, Hornshaw M, Wang L, Shaw C." "Kasstasin: A novel potent vasoconstrictor peptide from the skin secretion of the African red-legged running frog, Kassina maculata." DRAMP02130 GFLGPLLKLAAKGVAKVIPHLIPSRQQ 27 "Antimicrobial peptide 1 (XT-1; Frogs, amphibians, animals)" P84387 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E.coli and stronger activity against yeast C. albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells . Tissue specificity: Expressed by the skin glands." [Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacteria: Escherichia coli (MIC=6 ?M);##Fungi: Candida albicans (MIC=50 ?M) [Ref.11738090]HC50=90 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02131 GVWSTVLGGLKKFAKGGLEAIVNPK 25 "Antimicrobial peptide 2 (XT-2; Frogs, amphibians, animals)" P84382 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has very strong antibacterial activity against Gram-positive bacterium S. aureus and very weak activity against Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria: Escherichia coli (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02133 GVFLDALKKFAKGGMNAVLNPK 22 "Antimicrobial peptide 4 (XT-4; Frogs, amphibians, animals)" P84384 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and yeast C. albicans, and very weak activity against Gram-negative bacterium E.coli. Has strong hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." [Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria: Escherichia coli (MIC=18 ?M);##Fungi: Candida albicans (MIC>100 ?M). [Ref.11738090]HC50>150 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02135 GFLGSLLKTGLKVGSNLL 18 "Antimicrobial peptide 6 (XT-6; Frogs, amphibians, animals)" P84386 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E.coli and strong activity against yeast C. albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." "[Ref.11738090]Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=5 ?M);##Yeast: Candida albicans (MIC=40 ?M);##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 ?M), Staphylococcus aureus (MRSA) (MIC=7 ?M), Staphylococcus epidermidis 1420129 (MIC=3 ?M), S. saprophyticus 1950556 (MIC=13 ?M), Escherichia coli 25922 (MIC=6 ?M), Streptococcus group C 1541035 (MIC=3 ?M), Shigella sonnei 1840187 (MIC=35 ?M), Pseudomonas aeruginosa 0380972 (MIC=60 ?M), Enterobacter cloacae 1441323 (MIC=35 ?M)" [Ref.11738090]HC50=70 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02136 GLLGPLLKIAAKVGSNLL 18 "Antimicrobial peptide 7 (XT-7; Frogs, amphibians, animals)" P84381 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has very strong antibacterial activity against many Gram-negative bacteria and the Gram-positive bacteria S.pneumoniae and Enterococcus sp. There is moderate antimicrobial activity against the Gram-negative bacterium P.aeruginosa and yeast C. albicans and weaker activity against the Streptococcal strains and E.coli. Has hemolytic activity against human red blood cells (HC50=70 ?M). Seems to disrupt the membranes by adopting an alpha-helical conformation. Tissue specificity: Expressed by the skin glands. PTM: Amidation on Leu-18 is required to adopt an alpha-helical conformation in a hydrophobic solvent. The absence of amidation leads to a decrease in cationicity leading to a more than a 10-fold decrease in antimicrobial activities." "Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=5 ?M);##yeast Candida albicans (MIC=40 ?M).##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 ?M), Staphylococcus aureus (MRSA) (MIC=7 ?M), Staphylococcus epidermidis 1420129 (MIC=3 ?M), S. saprophyticus 1950556 (MIC=13 ?M), Escherichia coli 25922 (MIC=6 ?M), Streptococcus group C 1541035 (MIC=3 ?M), Shigella sonnei 1840187 (MIC=35 ?M), Pseudomonas aeruginosa 0380972 (MIC=60 ?M), Enterobacter cloacae 1441323 (MIC=35 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02219 GILSSFKGVAKGVAKNLAGKLLDELKCKITGC 32 "Ranatuerin-2AUa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana aurora aurora (Northern red-legged frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Activity against a range of Gram-positive and Gram-negative bacteria (minimum inhibitory concentrations<20 ?M) but low hemolytic activity against human erythrocytes. "[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=5 ?M), Pseudomonas aeruginosa (MIC=5 ?M), Enterobacter cloacae (MIC=5 ?M), Klebsiella pneumoniae (MIC=10 ?M), P. mirabilis (MIC>40 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=20 ?M), Staphylococcus epidermidis (MIC=20 ?M), Enterococcus faecalis (MIC>40 ?M), Streptococcus Group B (MIC=20 ?M);##Yeast: Candida albicans (MIC>40 ?M)" [Ref.15325526]HC50=290 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15325526 Dev Comp Immunol. 2005;29(1):83-90. "Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T." Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. DRAMP02220 GIMDTVKNVAKNLAGQLLDKLKCKITAC 28 "Ranatuerin-2PLa (Frogs, amphibians, animals)" A7WNV6 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 23-28." Gram-negative bacterium: Escherichia coli (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02221 GIMDTVKNAAKDLAGQLLDKLKCRITGC 28 "Ranatuerin-2PLb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02222 GLLDTIKNTAKNLAVGLLDKIKCKMTGC 28 "Ranatuerin-2PLc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02223 GIMDSVKNVAKNIAGQLLDKLKCKITGC 28 "Ranatuerin-2PLd (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02224 GIMDSVKNAAKNLAGQLLDTIKCKITAC 28 "Ranatuerin-2PLe (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02225 GIMDTVKNAAKDLAGQLDKLKCRITGC 27 "Ranatuerin-2PLf (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=23 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP18494 FIHHIIGGLFSAGKAIHRLIRRRRR 25 TP4 L0CKG3 Piscidin TP4 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) "Antibacterial, Antifungal, anticancer, wound healing, Anti-Gram+, Anti-Gram-, Antimicrobial" Protein level Alpha helix "1.0x sarkosyl can drive TP4 into a conformational change from a non-structure to an alpha-helical structure, and that LPS can also drive TP4 to an alpha-helical structure but with high hydrophobicity and low solubility." 5H2S Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. Has hemolytic activity. "[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=8 g/ml; MBC=16 g/ml), Methicillin-resistant Staphylococcus aureus (MIC=16 g/ml; MBC=32 g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa (MIC=64 g/ml; MBC=128 g/ml);##Fungi: Candida albicans (MIC=128 g/ml; MBC=128 g/ml)" "[Ref.29040295] 2% hemolysis at 0.78 g/ml, 5% hemolysis at 1.56 g/ml, 45% hemolysis at 3.13 g/ml, 85% hemolysis at 6.25 g/ml, 98% hemolysis at 12.50 g/ml, 100% hemolysis at 25.00 g/ml against mouse red blood cell" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet "bacterial outer membrane target protein, OprI-binding" 29040295 PLoS One. 2017 Oct 17;12(10):e0186442. "Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD." "Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4." DRAMP03002 GIGAVLKVLTTGLPALISWIKRKRQQ 26 "Melittin (Allergen Api m 3; Allergen Api m III; Insects, animals)" "P01501,P01503" Belongs to the melittin family MELT Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "2MLT, 3QRX, 1BH1" "Function: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. It increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. It acts synergistically with phospholipase A2. " "[Ref.29783753] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=2 M), Listeria monocytogenes CMCC 54004 (MIC=1 M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 M), Escherichia coli UB 1005 (MIC=2 M), Salmonella pullorum C7913 (MIC=8 M), Salmonella enterica subsp enterica CMCC 50071 (MIC=2 M)" [Ref.29859288] MHC=1 M against human red blood cell.##[Ref.2978375] 46.80% hemolysis at 2M against human red blood cell##[Ref.20472009] Wild-type melittin:AVG S.D.(%)=0.0770.002 (35) against human red blood cell. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (forms a transmembrane alpha-helix in the cell membrane.) 29859288##29783753##6309516##20472009##20403370##5300771 Gene. 2018 May 30. pii: S0378-1119(18)30617-6.##Molecules. 2018 May 19;23(5). pii: E1220. ##Eur J Biochem. 1983 Sep 1;135(1):123-126.##Peptides. 2010 Aug;31(8):1473-1479.##Toxicon. 2010 Sep 1;56(3):355-362.##Res Dev Tech Rep. 1967 Dec 5:1-13. "Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S.##Hou J, Liu Z, Cao S, Wang H, Jiang C, Hussain MA, Pang S.##Vlasak R, Unger-Ullmann C, Kreil G, Frischauf AM.##Sciani JM, Marques-Porto R, Louren?o Junior A, Orsi Rde O, Ferreira Junior RS, Barraviera B, Pimenta DC.##Ferreira Junior RS, Sciani JM, Marques-Porto R, Junior AL, Orsi Rde O, Barraviera B, Pimenta DC.##Fennell JF, Shipman WH, Cole LJ." Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro.##Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine AlphaS1-Casein.##Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin.##Identification of a novel melittin isoform from Africanized Apis mellifera venom.##Africanized honey bee (Apis mellifera) venom profiling: Seasonal variation of DRAMP02237 GLMDTIKGVAKTVAASWLDKLKCKITGC 28 "Ranatuerin-2Ya (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Not found "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Ranatuerin-2Ya showed appreciably greater cytolytic activity against HepG2 cells (LC(50)=20microM) than against erythrocytes (LC(50)>100microM). [Ref.19254736] Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M). [Ref.19254736] LC50>100 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP02238 GLADYWRTAFRANFANLGPGIRCKSARC 28 "Ranatuerin-2ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=6 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>32 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP02239 SMISVLKNLGKVGLGFVACKVNKQC 25 "Ranatuerin-1Ga (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grylio (North American pig frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=3.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M).##Yeast: Candida albicans (MIC=110 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10828493 Regul Pept. 2000 Jun 30;90(1-3):53-60. "Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM." Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio. DRAMP02241 GLLLDTLKGAAKDIAGIALEKLKCKITGCKP 31 "Ranatuerin-2G (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grylio (North American pig frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=19 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=150 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10828493 Regul Pept. 2000 Jun 30;90(1-3):53-60. "Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM." Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio. DRAMP01390 TSRCYIGYRRKVVCS 15 "Odorranain-T1 (OdT1; Frogs, amphibians, animals)" A6MBS1 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-T1 adopts 28.2% turn structure in water solution. None Function: Odorranain-T1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=17.50 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=35.00 g/ml), Bacillus subtilis (MIC=17.50 g/ml).##Yeast: Candida albicans (MIC=8.75 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01389 FLPPSPWKETFRTS 14 "Odorranain-S1 (OdS1; Frogs, amphibians, animals)" "A6MBS0, A6MBR9" Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-S1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=42.50 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=21.25 g/ml), Bacillus subtilis (MIC=85.00 g/ml).##Yeast: Candida albicans (MIC=21.25 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02251 GILSSFKGVAKGVAKDLAGKLLETLKCKITGC 32 "Ranatuerin-2CSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Alpha helix (4 helices; 25 residues) "In a 2,2,2-trifluoroethanol (TFE-d(3))-H(2)O solvent mixture, the structure is characterised by a full length helix-turn-helix conformation between residues I(2)-L(21), L(22)-L(25) and K(26)-T(30), respectively." 2K10 resolved by NMR. Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has Hemolytic activity against human erythrocytes. [Ref.17451843]Gram-negative bacterium:Escherichia coli ATCC 25726 (MIC=5 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10 ?M) [Ref.17451843] LD50=150 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys32) Disulfide bond between Cys27 and Cys32. L No cytotoxicity information found Not found 17451843##18387372 Peptides. 2007 Jun;28(6):1268-1274.##Biochim Biophys Acta. 2008 Jun;1784(6):924-929. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C.##Subasinghage AP, Conlon JM, Hewage CM." "Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.##Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: identification of a full length helix-turn-helix motif." DRAMP02252 GLLDAIKDTAQNLFANVLDKIKCKFTKC 28 "Ranatuerin 2SKa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sakuraii (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M).##Yeast: Candida albicans (MIC>50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys28) Disulfide bond between Cys23 and Cys28. L No cytotoxicity information found Not found 17174009 Peptides. 2007 Mar;28(3):505-514. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii. DRAMP01108 GIGTKILGGVKTALKGALKELASTYVN 27 "Maximin-2 (Toads, amphibians, animals)" "P83081, P83086, Q58T49" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP03998 RKKWFW 6 PAF26 (Trp-rich; combinatorial library) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Synthetic Rich "In general, positively charged residues (arginine or lysine) and residues with aromatic rings (tryptophan or phenylalanine) rendered antifungal activity." None "Function: Antibacterial against Gram-negative bacterium. The antifungal mixture is also antibacterial, with a predominance of basic and aromatic residues." "[Ref.11976121] Gram-negative bacterium: Escherichia coli DH5 (MIC=160 ?M, IC50>80 ?M);##Fungi: Penicillium digitatum PHI-26 (MIC=20 ?M, IC50=11 1 ?M), Penicillium italicum PHI-1 (MIC=40 ?M, IC50=22 3 ?M), Botrytis cinerea CECT2100 (MIC=60 ?M, IC50=38 24 ?M), Fusarium oxysporum CECT2866 (MIC=80 ?M, IC50=45 4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11976121 Appl Environ Microbiol. 2002 May;68(5):2453-60. "Lpez-Garca B, Prez-Pay E, Marcos JF." Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library. DRAMP01107 GIGTKILGGVKTALKGALKELASTYAN 27 "Maximin-1 (Toads, amphibians, animals)" "P83080, Q58T87" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity. Toxic dose: LD50 is 8.2 mg/kg by intraperitoneal injection into mice. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml);##Virus: HIV-1 (IC50=15.5 ?g/ml, EC50=21.4 ?g/ml);##Cancer cell lines: C8166 (IC50=15.3 ?g/ml), Molt-4 (IC50=24.3 ?g/ml), BIU-87 (IC50=20.5 ?g/ml), T24 (IC50=35.4 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP02268 GWASKIGQTLGKIAKVGLKELIQPK 25 "Xenopsin precursor fragment (XPF; Frogs, amphibians, animals)" P07198 Belongs to the magainin family Not found Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: XPF has antimicrobial activity. Tissue specificity: XPF is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa, it is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli (MIC=16-31 ?g/ml), K. Pneumonae (MIC=62-125 ?g/ml), Pseudomonas aeruginosa (MIC=125-250 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 ?g/ml), Streptococcus faecalis (MIC=250-500 ?g/ml).##Yeast: Candida albicans (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1717472 J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02269 GVLSNVIGYLKKLGTGALNAVLKQ 24 "Antimicrobial peptide PGQ (PGQ; Frogs, amphibians, animals)" P39080 Belongs to the magainin family pgq Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix(potential) Not found None "Function: Antimicrobial peptide. Tissue specificity: Is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli (MIC=62-250 ?g/ml), K. Pneumonae (MIC=125-250 ?g/ml), Pseudomonas aeruginosa (MIC=250-500 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 ?g/ml), Streptococcus faecalis (MIC=250-500 ?g/ml).##Yeast: Candida albicans (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1717472 J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02271 GIGKFLHSAKKFGKAFVGEIMNS 23 "Magainin-2 (Magainin II; chain of Magainins; Frogs, amphibians, animals)" C0HKN6 Belongs to the gastrin/cholecystokinin family. Magainin subfamily. N/A Xenopus ruwenzoriensis (Uganda clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix "The secondary structure is shown to be helical in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution." "2MAG, 2LSA resolved by NMR." "Function: Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents. Tissue specificity: Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli D31 (MIC=5 ?g/ml), Klebsiella pneumoniae (MIC=10 ?g/ml), Escherichia coli (MIC=50 ?g/ml), Pseudomonas putida (MIC=10 ?g/ml), Citrobacter freundii (MIC=30 ?g/ml), Enterobacter cloacae (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Serratia marcescens (MIC=100 ?g/ml), Proteus mirabilis (MIC>100 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis (MIC=10 ?g/ml), Staphylococcus aureus (MIC=50 ?g/ml), Streptococcus fecalis (MIC>100 ?g/ml).##Protozoa: Paramecium caudatum (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=80 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 3299384##9090128##PubMed ID is not available Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-5453.##J Biomol NMR. 1997 Feb;9(2):127-135.##To be Published. "Zasloff M.##Gesell J, Zasloff M, Opella SJ.##Vermeer LS, Kozlowska J, Lorenz CD, Mason JA." "Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.##Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution.##All Atom Simulations of the Initial Binding of Magainin and Pleurocidin to Membranes Comprising a Mixture of Anionic and Zwitterionic" DRAMP02272 GMASKAGAIAGKIAKVALKAL 21 "PGLa (chain of PYLa/PGLa A; Frogs, amphibians, animals)" "Q99134, B7ZSG6, Q91826" Belongs to the gastrin/cholecystokinin family (Magainin subfamily) pgla-a AND pgla-b Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: PGLa display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa also displays antifungal activity against C. albicans ATCC 14053. Tissue specificity: Expressed by the skin glands. Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. Stored as active, processed peptides in large granules within the granular gland secretions of the skin. PTM: Leucine amide at position 21." "Gram-negative bacteria: Escherichia coli 25922 (MIC=62-125 ?g/ml), Klebsiella pneumoniae 13883 (MIC=250-500 ?g/ml), Pseudomonas aeruginosa 27853 (MIC=250-500 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=125-500 ?g/ml), Strepococcus faecalis (MIC>500 ?g/ml).##Yeast: Candida albicans 14053 (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 3606567##1717472 Biochem J. 1987 Apr 1;243(1):113-120.##J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Giovannini MG, Poulter L, Gibson BW, Williams DH.##Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones.##Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02273 KIAKVALKAL 10 "PGLa-H (chain of PYLa/PGLa A; Frogs, amphibians, animals)" "Q99134, B7ZSG6, Q91826" Belongs to the gastrin/cholecystokinin family (Magainin subfamily) pgla-a AND pgla-b Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: PGLa-H display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa-H shows moderate antibacterial activity against the multidrug-resistant methicillin-resistant S. aureus (MRSA) but exhibits hemolytic activity. Tissue specificity: Expressed by the skin glands. Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. Stored as active, processed peptides in large granules within the granular gland secretions of the skin. PTM: Leucine amide at position 10." "[Ref.22014884]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.7 ?g/ml), Bacillus subtilis (MIC=14.4 ?g/ml), Staphylococcus aureus (MRSA) (MIC=67.8 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.6 ?g/ml)" "[Ref.22014884]3.15% hemolytic activity at 100 g/mL, 7.95% hemolytic activity at 200 g/mL against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22014884##1717472 Int J Antimicrob Agents. 2011 Dec;38(6):510-515.##J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Hou F, Li J, Pan P, Xu J, Liu L, Liu W, Song B, Li N, Wan J, Gao H.##Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis.##Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02274 SAPRGCWTKSYPPKPCK 17 "Ranacyclin-E (Frogs, amphibians, animals)" P83663 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Has hemolytic activity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Tissue specificity: Expressed by the skin granular glands." "[Ref.14636071]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3 ?M), Staphylococcus lentus (MIC=7 ?M), Micrococcus luteus (MIC=5 ?M);##Gram-negative bacteria: Yersinia pseudotuberculosis YP III (MIC=9 ?M), Pseudomonas syringae pv tabaci (MIC=80 ?M);##Fungi: Candida tropicalis (MIC=7.4 ?M), C. guillermondii (MIC=3.4 ?M), Phytophthora nicotianae spores (MIC=32 ?M)." [Ref.14636071] It has 55% hemolytic activity at 100 M against human erythrocytes Cyclic Free Amidation Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Cell membrane 14636071 Biochemistry. 2003 Dec 2;42(47):14023-14035. "Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M." "Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity." DRAMP02275 GALRGCWTKSYPPKPCK 17 "Ranacyclin-T (Frogs, amphibians, animals)" P83719 Belongs to the frog skin active peptide family (Brevinin subfamily) RNCT Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None MOA: The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Has hemolytic activity. "[Ref.14636071]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3 ?M), Staphylococcus lentus (MIC=10 ?M), Micrococcus luteus (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=30 ?M), Yersinia pseudotuberculosis YP III (MIC=5 ?M), Pseudomonas syringae pv tabaci (MIC=16 ?M);##Fungi: Candida albicans ATCC 10231 (MIC=22 ?M), Candida tropicalis (MIC=14 ?M), C. guillermondii (MIC=1 ?M), Phytophthora nicotianae spores (MIC=16 ?M)." [Ref.14636071] It has 20% hemolytic activity at 100 M against human erythrocytes Cyclic Free Amidation Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Cell membrane 14636071 Biochemistry. 2003 Dec 2;42(47):14023-14035. "Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M." "Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity." DRAMP02278 AALRGCWTKSIPPKPCPGKR 20 "Ranacyclin-B-RL1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana livida (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus (MIC=5.8 ?M), Bacillus subtilis (MIC=46.2 ?M);##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02288 FIGPVLKIAAGILPTAICKIFKKC 24 "Gaegurin-RN1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells.. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=2.34 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=4.69 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=18.75 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 ?g/ml)" [Ref.19778602] It has 46.13 1.49% hemolytic activity at 100 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP02290 FLGPIIKIATGILPTAICKFLKKC 24 "Gaegurin-RN5 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=3.75 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=62.50 ?g/ml), Bacillus subtilis (MIC=4.69 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 ?g/ml)." [Ref.19778602] It has no detectable hemolysis at the concentration up to 100 g/ml Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP02291 SLFSLIKAGAKFLGKNLLKQGACYAACKASKQC 33 "Gaegurin-1 (Gaegurin 1; GGN1; Frogs, amphibians, animals)" P80395 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN1 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has hemolytic activity against rabbit red cells. "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=5 ?g/ml), Staphylococcus epidermidis (MIC=50 ?g/ml), Bacillus subtilis (MIC=50 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=100 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=25 ?g/ml)." "[Ref.7999137] It has 0.04% hemolytic activity at 0.1 g/ml, 0.14% hemolytic activity at 1 g/ml, 0.51% hemolytic activity at 10 g/ml, 0.59% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung J-E, Lee BJ.1994" "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02292 GIMSIVKDVAKNAAKEAAKGALSTLSCKLAKTC 33 "Gaegurin-2 (Gaegurin 2; GGN2; Frogs, amphibians, animals)" P80396 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN2 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=75 ?g/ml).##Fungi: Saccharomyces cerevisiae (MIC=150 ?g/ml), Candida albicans (MIC=150 ?g/ml), Salmonella typhimurium (MIC=150 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.19% hemolytic activity at 0.1 g/ml, 0.16% hemolytic activity at 1 g/ml, 0.31% hemolytic activity at 10 g/ml, 0.82% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02293 GIMSIVKDVAKTAAKEAAKGALSTLSCKLAKTC 33 "Gaegurin-3 (Gaegurin 3; GGN3; Frogs, amphibians, animals)" P80397 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN3 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=75 ?g/ml).##Fungi: Saccharomyces cerevisiae (MIC>200 ?g/ml), Candida albicans (MIC>200 ?g/ml), Salmonella typhimurium (MIC=150 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.11% hemolytic activity at 0.1 g/ml, 0.12% hemolytic activity at 1 g/ml, 0.35% hemolytic activity at 10 g/ml, 1.20% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02294 GILDTLKQFAKGVGKDLVKGAAQGVLSTVSCKLAKTC 37 "Gaegurin-4 (Gaegurin 4; GGN4; Frogs, amphibians, animals)" "P80398, Q91328, Q98TA6" Belongs to the frog skin active peptide family (Brevinin subfamily) GGN4 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (3 helices; 22 residues) "In 100% H2O, Gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34 (Ref.2)." 2G9L resolved by NMR. "Function: Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. Has hemolytic activity against rabbit red cells. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 31-37." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=100 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=75 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=200 ?g/ml), Candida albicans (MIC=200 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.50% hemolytic activity at 0.1 g/ml, 0.74% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 1.67% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 7999137##17141187##11004488 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.##Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-597.##Biochim Biophys Acta. 2000 Jun 21;1492(1):185-190. "Park JM, Jung JE, Lee BJ.##Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH.##Kwon SY, Carlson BA, Park JM, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa.##Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.##Structural organization and expression of the gaegurin 4 gene of Rana rugosa." DRAMP02295 FLGALFKVASKVLPSVFCAITKKC 24 "Gaegurin-5 (Gaegurin 5; GGN5; Brevinin-1EMa; Frogs, amphibians, animals)" "P80399, Q91329" Belongs to the frog skin active peptide family (Brevinin subfamily) GGN5 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Not found Not found None "Function: Has low hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. PTM: Problely contains one disulfide bond 18-24." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=50 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=50 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=50 ?g/ml), Candida albicans (MIC=50 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.19% hemolytic activity at 0.1 g/ml, 0.31% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 1.01% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02296 FLPLLAGLAANFLPTIICKISYKC 24 "Gaegurin-6 (Gaegurin 6; GGN6; Frogs, amphibians, animals)" P80400 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN6 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has low hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. PTM: Problely contains one disulfide bond 18-24." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=50 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=50 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=50 ?g/ml), Candida albicans (MIC=50 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.39% hemolytic activity at 0.1 g/ml, 0.62% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 0.86% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02314 RCRFCCRCCPRMRGCGICCRF 21 "Hepcidin (fish, chordates, animals)" A1Z0M0 Belongs to the hepcidin family hamp Larimichthys crocea (Croceine croaker) (Pseudosciaena crocea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Tissue specificity: Expressed in all tissues tested, with highest levels of expression in kidney and lowest levels in liver. Intra-peritoneal injection of lipopolysaccharide results in increased expression in heart, spleen and stomach, but not in kidney or liver. PTM: Contains four disulfide bonds 2-19; 5-8; 6-15; 9-18." "Gram-negative bacteria: Vibrio alginolyticus(MIC=24 ?M), V. fluvialis, V. harveyis (MIC=12 ?M) and Vibrio parahaemolyticus (MIC=6 ?M), Aeromonas hydrophila (MIC=6 ?M), Escherichia coli (MIC=24 ?M), Escherichia coli BL21(DE3)plysS (MIC=6 ?M);##Gram-positive bacteria: Bacillus cereus (MIC=24 ?M), Bacillus subtilis (MIC=6 ?M), C. glutamicum (MIC=3 ?M), Micrococcus luteus (MIC=3 ?M), M. lysodeikticus, Staphylococcus aureus (MIC=6 ?M) and S.epidermis (MIC=12 ?M).##Fungi: Aspergillus niger (MIC=24 ?M), F;##Graminearum (MIC=24 ?M) and Fusarium solani (MIC=24 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys19; Cys5 and Cys8; Cys6 and Cys15,Cys9 and Cys18." L No cytotoxicity information found Not found 19150638##19344770 Peptides. 2009 Apr;30(4):638-646.##Fish Shellfish Immunol. 2009 Jun;26(6):864-870. "Wang KJ, Cai JJ, Cai L, Qu HD, Yang M, Zhang M.##Zhang J, Yan Q, Ji R, Zou W, Guo G." "Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide.##Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea." DRAMP02315 FFGWLIKGAIHAGKAIHGLIHRRRH 25 "Chrysophsin-1 (fish, chordates, animals)" P83545 Belongs to the pleurocidin family Not found Chrysophrys major (Red sea bream) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Shows hemolytic activity human red blood cells. "[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=10 ?M), S.iniae F-8502 (MIC=2.5 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=2.5 ?M), Vibriopenaeicida KHA (MIC=10 ?M), V. harveyi ATCC 14126 (MIC=2.5 ?M), V. vulnificus ATCC 33148 (MIC=5 ?M), Aeromonas salmonicida NCMB 1102 (MIC=10 ?M), Pseudomonas putida ATCC 12633 (MIC=40 ?M)." "[Ref.12581207]10% hemolytic activity at 0.25 M, 80% hemolytic activity at 1 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12581207 Eur J Biochem. 2003 Feb;270(4):675-686. "Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T." "Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major." DRAMP02316 FFGWLIRGAIHAGKAIHGLIHRRRH 25 "Chrysophsin-2 (fish, chordates, animals)" P83546 Belongs to the pleurocidin family Not found Chrysophrys major (Red sea bream) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Shows hemolytic activity human red blood cells. "[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=5 ?M), S.iniae F-8502 (MIC=1.5 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=1.25 ?M), Vibriopenaeicida KHA (MIC=5 ?M), V. harveyi ATCC 14126 (MIC=5 ?M), V. vulnificus ATCC 33148 (MIC=2.5 ?M)." "[Ref.12581207]10% hemolytic activity at 0.25 M, 70% hemolytic activity at 1 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12581207 Eur J Biochem. 2003 Feb;270(4):675-686. "Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T." "Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major." DRAMP02317 FIGLLISAGKAIHDLIRRRH 20 "Chrysophsin-3 (fish, chordates, animals)" P83547 Belongs to the pleurocidin family Not found Chrysophrys major (Red sea bream) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Shows hemolytic activity human red blood cells. "[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=10 ?M), S.iniae F-8502 (MIC=10 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=10 ?M), Vibriopenaeicida KHA (MIC=10 ?M), V. harveyi ATCC 14126 (MIC=5 ?M), V. vulnificus ATCC 33148 (MIC=10 ?M), Aeromonas salmonicida NCMB 1102 (MIC=10 ?M), Pseudomonas putida ATCC 12633 (MIC=40 ?M)." "[Ref.12581207]0% hemolytic activity at 0.25 M, 10% hemolytic activity at 1 M against human erythrocytes." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12581207 Eur J Biochem. 2003 Feb;270(4):675-686. "Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T." "Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major." DRAMP02318 FIGGIISFFKRLF 13 "Grammistin Pp1 (Group II grammistin; fish, chordates, animals)" P69842 Belongs to the grammistin family (Group 2 subfamily) Not found Pogonoperca punctata (Clown grouper) (Bearded grouper) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=3.13 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=3.13 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC>50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Fish. Sci. 2001 Oct;67:928-933. "Yokota H, Nagashima Y, Shiomi K." Interaction of grammistins with lipids and their antibacterial activity. DRAMP02320 FIGGIISFIKKLF 13 "Grammistin PpIIb (Group II grammistin; fish, chordates, animals)" P69844 Belongs to the grammistin family (Group 2 subfamily) Not found Pogonoperca punctata (Clown grouper) (Bearded grouper) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Has antibacterial activities. "[Ref.Fish. Sci. 2001 Feb;67:163-169.]Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=3.13 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC>50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=12.5 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Phospholipids PubMed ID is not available Fish. Sci. 2001 Feb;67:163-169. "Shiomi K, Yokota H, Nagashima Y, Ishida M." "Primary and secondary structures of grammistins, peptide toxins isolated from the skin secretion of the soapfish Pogonoperca punctata." DRAMP02321 NWRKILGQIASVGAGLLGSLLAGYE 25 "Grammistin Pp3 (Group III grammistin; fish, chordates, animals)" P69847 Belongs to the grammistin family (Group 3 subfamily) Not found Pogonoperca punctata (Clown grouper) (Bearded grouper) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has hemolytic activity. Thanks to its abundant amphiphilic alpha-helices, it may integrate into membrane phospholipids, leading to lysis of the membrane." "[Ref.Fish. Sci. 2001 Oct;67:928-933.]Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=50 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=50 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC>50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=12.5 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=50 ?g/ml)." [Ref.Fish. Sci. 2001 Oct;67:928-933.]75 HU/mg hemolytic activity against horse erythrocytes(1 HU was defined as the amount of peptide causing 50% hemolysis) Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Fish. Sci. 2001 Oct;67:928-933. "Yokota H, Nagashima Y, Shiomi K." Interaction of grammistins with lipids and their antibacterial activity. DRAMP02324 AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS 30 "SAMP H1 (fish, chordates, animals)" "P84408, Q5GMQ6" Belongs to the histone H1/H5 family Not found Salmo salar (Atlantic salmon) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=2 ?M), Aeromonas salmonicida subsp salmonicida (MIC=4 ?M), Vibrio anguillarum (MIC=1 ?M) Salmonella typhimurium (MIC=4 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=2 ?M), Listeria ivanovii (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15917539 Antimicrob Agents Chemother. 2005 Jun;49(6):2399-2406. "Luders T, Birkemo G.A, Nissen-Meyer J, Andersen O, Nes I.F." Proline conformation-dependent antimicrobial activity of a proline-rich histone H1 N-terminal peptide fragment isolated from the skin mucus of Atlantic salmon. DRAMP02330 FFHHIFRGIVHVGKTIHRLVTG 22 "Piscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)" Q8UUG0 Belongs to the pleurocidin family Not found Morone saxatilis (Striped bass) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "2JOS, 2OJM resolved by NMR." Function: Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria. Also has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores. "[Ref.11713517]Gram-positive bacteria: Enterococcus faecalis VRE (MIC=5-10 ?M), E. faecalis (MIC=2.5-5 ?M), Listeria monocytogenes (MIC=2.5-5 ?M), Micrococcus luteus (MIC=10-20 ?M), Staphylococcus aureus MRSA (MIC=1.25-2.5 ?M), S. epidermitis (MIC=5-10 ?M), S. saprophiticus (MIC=5-10 ?M), Staphylococcus xylosus (MIC>20 ?M), S. agalactiae (MIC=1.25-2.5 ?M), S. bovis (MIC=1.25-2.5 ?M), S. equisimilis (MIC=2.5-5 ?M), S. mitis (MIC=1.25-2.5 ?M), S. Pneumonae (MIC=1.25-2.5 ?M), S. pyrogenes (MIC=1.25-2.5 ?M), Streptococcus iniae KST740 ak (MIC=1.25-2.5 ?M), S. iniae KSTSi 6P (MIC=1.25-2.5 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 ?M), Burkholderia cepacia (MIC>20 ?M), Vibrio Cholera (MIC=2.5-5 ?M), Escherichia coli (MIC=5-10 ?M), Enterobacter cloacae (MIC=10-20 ?M), E. Aerogenes (MIC=10-20 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), K. oxytoca (MIC=5-10 ?M), Salmonella choleraesuis (MIC=10-20 ?M), S. typhimurium (MIC=10-20 ?M), S. arizonae (MIC=10-20 ?M), Serratia marcescens (MIC>20 ?M), Shigella flexneri (MIC=2.5-5 ?M), S. sonnei (MIC=5-10 ?M), Yersinia enterocolitica (MIC=2.5-5 ?M); Fungi: Neurospora crassa (MIC=1.56-3.12 ?M), A. fumigatus (MIC=50-100 ?M), F. axysporum (MIC=0.78-1.56 ?M), F. culmorum (MIC=0.39-0.78 ?M), C. ablicans (MIC=10-20 ?M), C. glabrata (MIC=10-20 ?M), C. lusitania (MIC=10-20 ?M), C. tropacalis (MIC=10-20 ?M)." "[Ref.11713517]10% hemolytic activity at 5 g/mL, 60% hemolytic activity at 10 g/mL, 100% hemolytic activity at 50 g/mL against human erythrocytes " Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11713517 Nature. 2001 Nov 15;414(6861):268-269. "Silphaduang U, Noga EJ." Peptide antibiotics in mast cells of fish. DRAMP02331 FFHHIFRGIVHVGKTIHKLVTG 22 "Piscidin-2 (Pis-2; fish, chordates, animals)" Q8UUG2 Belongs to the pleurocidin family Not found Morone chrysops (White bass) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Seems to disrupt the membranes by adopting an alpha helical conformation. Tissue specificity: Expressed in gill, skin, intestine, spleen, anterior kidney, and blood cells." "Gram-positive bacteria: Enterococcus faecalis (MIC=5-10 ?M), E. faecalis (MIC=2.5-5 ?M), Listeria monocytogenes (MIC=2.5-5 ?M), Micrococcus luteus (MIC=10-20 ?M), Staphylococcus aureus (MIC=1.25-2.5 ?M), S. epidermidis (MIC=5-10 ?M), S. saprophiticus (MIC=5-10 ?M), S. xylosus (MIC>20 ?M), Streptococcus agalactiae (MIC=1.25-2.5 ?M), S. bovis (MIC=1.25-2.5 ?M), S. equisimilis (MIC=2.5-5 ?M), S. mitis (MIC=1.25-2.5 ?M), Streptococcus pneumoniae (MIC=1.25-2.5 ?M), Streptococcus pyogenes (MIC=1.25-2.5 ?M), S. iniae KST740ak (MIC=1.25-2.5 ?M), S. iniae KSTSi 6P (MIC=1.25-2.5 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 ?M), Burkholderia cepacia (MIC>20 ?M), Vibrio cholera (MIC=2.5-5 ?M), Escherichia coli (MIC=5-10 ?M), Moraxella catarrhalis (MIC=2.5-5 ?M), Neisseria gonorrhoeae (MIC>20 ?M), Pseudomonas aeruginosa (MIC=5-10 ?M), Enterobacter cloacae (MIC=10-20 ?M), E. aerogenes (MIC=10-20 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), K. oxytoca (MIC=5-10 ?M), Salmonella choleraesuis (MIC=10-20 ?M), Salmonella typhimurium (MIC=10-20 ?M), S. arizonae (MIC=10-20 ?M), Serratia marcescens (MIC>20 ?M), Shigella flexneri (MIC=2.5-5 ?M), S. sonnei (MIC=5-10 ?M), Yersinia enterocolitica (MIC=2.5-5 ?M).##Fungi: Neurospora crassa (MIC=1.56-3.12 ?M), Aspergillus fumigatus (MIC=50-100 ?M), Fusarium oxysporum (MIC=0.78-1.56 ?M), F. culmorum (MIC=0.39-0.78 ?M), Candida albicans (MIC=10-20 ?M), C. glabrata (MIC=10-20 ?M), C. lusitania (MIC=10-20 ?M), C. tropicalis (MIC=10-20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11739390 J Biol Chem. 2002 Feb 15;277(7):5030-5039. "Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Shimizu C, Bulet P." "Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass." DRAMP02336 KAVAAKKSPKKAKKPATPKKAAKSPKKVKKPAAAAKKAAKSPKKATKAAKPKAAKPKAAKAKKAAPKKK 69 "Oncorhyncin II (Oncorhyncin 2; fish, chordates, animals)" "P06350, P83374" Belongs to the histone H1/H5 family Not found Oncorhynchus mykiss (Rainbow trout) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Potentially important role in mucosal defense. "Gram-positive bacteria: Planococcus citreus (MIC=0.2-0.4 ?M), Micrococcus luteus (MIC=0.2-0.4 ?M);##Gram-negative bacteria: Escherichia coli (MIC=0.4-0.8 ?M), Listonella anguillarum (MIC=0.4-0.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12969798 Dev Comp Immunol. 2004 Feb;28(2):127-138. "Fernandes JM, Molle G, Kemp GD, Smith VJ." "Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss." DRAMP02337 PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAG 66 "Oncorhyncin III (Oncorhyncin 3; fish, chordates, animals)" "P02315, P83338" Belongs to the HMGN family Not found Oncorhynchus mykiss (Rainbow trout) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Plays a role in mucosal innate host defence. "Gram-positive bacteria: Aerococcus viridans (MIC=0.06-0.12 ?M), Bacillus subtilis (MIC=0.25-0.5 ?M), Micrococcus luteus (MIC=0.12-0.25 ?M), Planococcus citreus (MIC=0.06-0.12 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>0.5 ?M), Aeromonas salmonicida 004 (MIC>0.5 ?M), Escherichia coli (MIC=0.25-0.5 ?M), Listonella anguillarum (MIC=0.25-0.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet DNA 12713443 Biochem J. 2003 Jul 15;373(Pt 2):621-628. "Fernandes J.M.O, Saint N, Kemp G.D, Smith V.J." "Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss." DRAMP02347 GKGRWLERIGKAGGIIIGGALDHL 24 "NRC-1 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "C-terminal NH2, this NRC seris of peptides was identified by gene analysis and biological activity verified using synthetic peptides. " "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 ?g/ml), Aeromonas salmonicida 97-4 (MIC=64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), Escherichia coli UB1005 (MIC=32 ?g/ml), Escherichia coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02348 WLRRIGKGVKIIGGAALDHL 20 "NRC-2 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1a) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>128 ?g/ml), Aeromonas salmonicida 97-4 (MIC=128 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), E. coli UB1005 (MIC=64 ?g/ml), E. coli DC2 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02349 GRRKRKWLRRIGKGVKIIGGAALDHL 26 "NRC-3 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1a-1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), Aeromonas salmonicida 97-4 (MIC=4 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), Escherichia coli UB1005 (MIC=8 ?g/ml), Escherichia coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=8 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02350 GWGSFFKKAAHVGKHVGKAALTHYL 25 "Pleurocidin (NRC-4; fish, chordates, animals)" "P81941, P81619, Q9PRJ9, Q90ZY0, Q90VW6" Belongs to the pleurocidin family ple1 AND ple2 Pseudopleuronectes americanus (Winter flounder 2-2.1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 19 residues) "From NMR structural studies with the uniformly (15)N-labeled peptide, a structure of pleurocidin is determined to be in a random coil conformation in aqueous solution whereas it assumes an alpha-helical structure in TFE and in dodecylphosphocholine (DPC) micelles.(Ref.2)" 1Z64?resolved by NMR. May play a role in innate host defense. "Gram-negative bacteria: Escherichia coli (MIC=2.2-3.3 ?M), Leucothrix mucor (MIC>35.0 ?M), Serratia marcescens (MIC>35.0 ?M), Pseudomonas aeruginosa (MIC>35.0 ?M), Aeromonas salmonicida (MIC=17.7-35.0 ?M), Cytophaga aquatilis (MIC=2.2-4.4 ?M), Pasteurella haemolytica (MIC=4.4-8.8 ?M), Salmonella typhimurium I (MIC=8.8-17.7 ?M), Salmonella typhimurium II (MIC=8.8-17.7 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=1.1-2.2 ?M), Staphylococcus aureus (MIC=17.7-35.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9115266 J Biol Chem. 1997 May 2;272(18):12008-12013. "Cole A.M, Weis P, Diamond G." "Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder." DRAMP02351 FFRLLFHGVHHVGKIKPRA 19 "NRC-10 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder Z) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), Aeromonas salmonicida 97-4 (MIC=32 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), Escherichia coli UB1005 (MIC=32 ?g/ml), Escherichia coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus C623 (MRSA) (MIC=64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02352 GWKKWLRKGAKHLGQAAIK 19 "NRC-16 (fish, chordates, animals)" No entry found Not found Not found Glyptocephalus cynoglossus (Witch flounder GC3.8-t) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=1 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=0.5 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=16 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=1 ?g/ml), E. coli UB1005 (MIC=2 ?g/ml), E. coli DC2 (MIC=0.5 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02354 FFRLLFHGVHHGGGYLNAA 19 "Pleurocidin-like peptide WFY (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida A449 field isolate (MIC>64 ?g/ml), A. salmonicida 97-4 field isolate (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC4908 triple (MIC=64 ?g/ml), Salmonella typhimurium 14028s (MIC>64 ?g/ml), Salmonella typhimurium MS7953s (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis (human clinical isolates) (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) (MIC>64 ?g/ml).##Fungi: Candida albica (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12950255 Eur J Biochem. 2003 Sep;270(18):3720-3730. "Douglas SE, Patrzykat A, Pytyck J, Gallant JW." "Identification, structure and differential expression of novel pleurocidins clustered on the genome of the winter flounder, Pseudopleuronectes americanus (Walbaum)." DRAMP02357 FLGALIKGAIHGGRFIHGMIQNHH 24 "Pleurocidin-like peptide WF3 (NRC-5; fish, chordates, animals)" Q90VW7 Belongs to the pleurocidin family ple3 Pseudopleuronectes americanus (Winter flounder 3) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), Escherichia coli UB1005 (MIC=64 ?g/ml), Escherichia coli DC2 (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506##11113283 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.##Dev Comp Immunol. 2001 Mar;25(2):137-147. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.##Douglas SE, Gallant JW, Gong Z, Hew C." "Novel antimicrobial peptides derived from flatfish genes.##Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum)." DRAMP02358 GWGSIFKHGRHAAKHIGHAAVNHYL 25 "Pleurocidin-like peptide WF4 (NRC-6; fish, chordates, animals)" "Q90ZX8, Q90ZX9" Belongs to the pleurocidin family ple4 Pseudopleuronectes americanus (Winter flounder 4-1.1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=4 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=16 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC=32 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506##11113283 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.##Dev Comp Immunol. 2001 Mar;25(2):137-147. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.##Douglas SE, Gallant JW, Gong Z, Hew C." "Novel antimicrobial peptides derived from flatfish genes.##Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum)." DRAMP02359 RWGKWFKKATHVGKHVGKAALTAYL 25 "Pleurocidin-like peptide YT2 (NRC-7; fish, chordates, animals; Predicted)" Q7SZH1 Not found ple Limanda ferruginea (Yellowtail flounder YT2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=2 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=64 ?g/ml).##Yeast: Candida albicans C627 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02360 GWKSVFRKAKKVGKTVGGLALDHYLG 26 "Pleurocidin-like peptide AP1 (NRC-11; fish, chordates, animals; Predicted)" Q7SZH4 Not found ple Hippoglossoides platessoides (American plaice AP1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 ?g/ml), A. salmonicida 97-4 (MIC=8 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=32 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=16?g/ml), E. coli DC2 (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC=32 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02361 GWKKWFNRAKKVGKTVGGLAVDHYLG 26 "Pleurocidin-like peptide AP2 (NRC-12; fish, chordates, animals; Predicted)" Q7SZH3 Not found ple Hippoglossoides platessoides (American plaice AP2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), E. coli UB1005 (MIC=8 ?g/ml), E. coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: S. epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02362 GWRTLLKKAEVKTVGKLALKHYL 23 "Pleurocidin-like peptide AP3 (NRC-13; fish, chordates, animals; Predicted)" Q7SZH2 Not found ple Hippoglossoides platessoides (American plaice AP3) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=2 ?g/ml).##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02363 AGWGSIFKHIFKAGKFIHGAIQAHND 26 "Pleurocidin-like peptide GcSc4C5 (NRC-14; fish, chordates, animals)" Q7SZH0 Not found ple Glyptocephalus cynoglossus (Witch flounder GcSc4C5) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=32 ?g/ml), A. salmonicida 97-4 (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=16 ?g/ml), E. coli UB1005 (MIC=16 ?g/ml), E. coli DC2 (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02364 GFWGKLFKLGLHGIGLLHLHL 21 "Pleurocidin-like peptide GcSc4B7 (NRC-15; fish, chordates, animals; Predicted)" Q7SZG9 Not found ple Glyptocephalus cynoglossus (Witch flounder GcSc4B7) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 ?g/ml), A. salmonicida 97-4 (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=16 ?g/ml), Pseudomonas aeruginosa K799 (MIC=8 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=8 ?g/ml), E. coli UB1005 (MIC=8 ?g/ml), E. coli DC2 (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 ?g/ml).##Yeast: Candida albicans C627 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02365 GWKKWLRKGAKHLGQAAIKGLAS 23 "Pleurocidin-like peptide GC3.8 (NRC-17; fish, chordates, animals; Predicted)" Q7SZG8 Not found ple Glyptocephalus cynoglossus (Witch flounder GC3.8) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=1 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=1 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=2 ?g/ml), Escherichia coli CGSC 4908 (MIC=1 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02366 GWKKWFTKGERLSQRHFA 18 "Pleurocidin-like peptide GC3.2 (NRC-18; fish, chordates, animals; Predicted)" Q7SZG7 Not found ple Glyptocephalus cynoglossus (Witch flounder GC3.2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC=128 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=32 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), E. coli UB1005 (MIC=64 ?g/ml), E. coli DC2 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02367 FLGLLFHGVHHVGKWIHGLIHGHH 24 "Pleurocidin-like peptide Hb26 (NRC-19; fish, chordates, animals; Predicted)" Q7SZG6 Not found ple Hippoglossus hippoglossus (Halibut Hb26) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), E. coli UB1005 (MIC=16 ?g/ml), E. coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=8 ?g/ml).##Yeast: Candida albicans C627 (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02368 GFLGILFHGVHHGRKKALHMNSERRS 26 "Pleurocidin-like peptide Hb18 (NRC-20; fish, chordates, animals; Predicted)" Q7SZG5 Not found ple Hippoglossus hippoglossus (Halibut Hb18) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC>64 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC 4908 (MIC>64 ?g/ml), E. coli UB1005 (MIC>64 ?g/ml), E. coli DC2 (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02374 GCRFCCNCCPNMSGCGVCCRF 21 "Bass hepcidin (fish, chordates, animals)" P82951 Belongs to the hepcidin family hamp Morone chrysops x Morone saxatilis (white bass x striped sea-bass) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Beta strand (2 strands; 6 residues) "Solution structure by NMR indicates that bass hepcidin is very similar to that of human hepcidin, including the presence of an antiparallel beta-sheet, a conserved disulfide-bonding pattern, and a rare vicinal disulfide bond." 1S6W resolved by NMR. "Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity). Synthetic bass hepcidin is active in vitro against Gram-negative pathogens and fungi but showes no activity against key Gram-positive pathogens and a single yeast strain tested. Tissue specificity: Predominantly expressed in liver. Induction: By bacterial challenge. PTM: Contains four disulfide bonds 2-19; 5-8; 6-15; 9-18." "Gram-negative bacteria: Escherichia coli ATCC 25,922,351,50 (MIC=22 ?M), Escherichia coli ATCC D31K (MIC=11 ?M), Klebsiella pneumoniae ATCC 10,031 (MIC=22 ?M), P. shigelloides ATCC KST (MIC=11 ?M), S. flexneri ATCC 12,022 (MIC=22 ?M), Shigella sonnei ATCC 9290 (MIC=44 ?M), Y. enterocolitica ATCC 23,715 (MIC=22 ?M).##Fungi: Aspergillus niger (MIC=44 ?M)." [Ref.15546886] It displays essentially no hemolytic activity toward HSB erythrocytes Cyclic Free Free "Disulfide bonds between Cys2 and Cys19; Cys5 and Cys8; Cys6 and Cys15,Cys9 and Cys18." L No cytotoxicity information found Not found 11985602##15546886 Eur J Biochem. 2002 Apr;269(8):2232-2237.##J Biol Chem. 2005 Mar 11;280(10):9272-9282. "Shike H, Lauth X, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Shimizu C, Bulet P, Burns JC.##Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME." "Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge.##Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections." DRAMP02376 LFGFLIKLIPSLFGALSNIGRNRNQ 25 "Grammistin Gs 1 (Grammistin Gs F; Group I grammistin; soapfish, chordates, animals)" P69835 Belongs to the grammistin family (Group 1 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=12.5 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=12.5 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Fish. Sci. 2001 Oct;67:928-933. "Yokota H, Nagashima Y, Shiomi K." Interaction of grammistins with lipids and their antibacterial activity. DRAMP02377 LFGFLIPLLPHIIGAIPQVIGAIR 24 "Grammistin Gs 2 (Grammistin Gs G; Group I grammistin; soapfish, chordates, animals)" P69836 Belongs to the grammistin family (Group 1 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=12.5 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), Photobacterium damselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=25 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Fish. Sci. 2001 Oct;67:928-933. "Yokota H, Nagashima Y, Shiomi K." Interaction of grammistins with lipids and their antibacterial activity. DRAMP02378 WWRELLKKLAFTAAGHLGSVLAAKQSGW 28 "Grammistin Gs A (Group III grammistin; soapfish, chordates, animals)" P69845 Belongs to the grammistin family (Group 3 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15777955 Toxicon. 2005 Apr;45(5):595-601. "Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K." Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus. DRAMP02379 IGGIISFFKRLF 12 "Grammistin Gs B (Group II grammistin; soapfish, chordates, animals)" P69839 Belongs to the grammistin family (Group 2 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=12.5 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC=12.5 ?g/ml), S. putrefaciens IAM 1509 (MIC=3.13 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=6.25 ?g/ml), Vibrio parahaemolyticus (MIC=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15777955 Toxicon. 2005 Apr;45(5):595-601. "Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K." Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus. DRAMP02380 NWRKILGKIAKVAAGLLGSMLAGYQV 26 "Grammistin Gs C (Group III grammistin; soapfish, chordates, animals)" P69846 Belongs to the grammistin family (Group 3 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "MOA: Thanks to its amphiphilic alpha-helice(s), it may integrate into membrane phospholipids, leading to lysis of the membrane." "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=12.5 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC=12.5 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15777955 Toxicon. 2005 Apr;45(5):595-601. "Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K." Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus. DRAMP18373 CMSYGGSCQRSCNGGFRLGGHCGHPKIRCCRRK 33 mBD-6 (Murine beta-defensin 6) No entry found Belongs to the beta-defensin family. Not found Mus musculus "Antimicrobial, Antibacterial, Anti-Gram-" bridge Not found None Comment: No comments found on DRAMP database Gram-negative bacteria: E. coli. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11408484 J Biol Chem. 2001 Aug 24;276(34):31510-4 "Yamaguchi Y, Fukuhara S, Nagase T, Tomita T, Hitomi S, Kimura S, Kurihara H, Ouchi Y." "A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle." DRAMP18374 FFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCCRTIQPSGSIID 45 hBD-6 (human beta-defensin 6) No entry found Belongs to the beta-defensin family. Not found Homo sapiens "Antimicrobial, Antibacterial, Anti-Gram-, Chemotactic" beta Not found 2LWL Comment: No comments found on DRAMP database Gram-negative bacteria: E. coli K12. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12193721 J Immunol. 2002 Sep 1;169(5):2516-23 "Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y." Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. DRAMP02390 RPRPNYRPRPIYRP 14 "Astacidin 2 (crayfish, Arthropods, animals)" Q0PJU7 Not found Not found Pacifastacus leniusculus (signal crayfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Rich Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Shigella flexneri ATCC 203 (MIC=0.98 ?g/ml), Proteus vulgaris OX19 ATCC 6380 (MIC=7.8 ?g/ml), Escherichia coli D21 (MIC=3.9 ?g/ml), Psedomonas aeruginosa OT 97 (MIC=7.8 ?g/ml).##Gram-positive bacteria: Bacillus megateriun B11 (MIC=1.9 ?g/ml), Bacillus subtilis ATCC 6633 (MIC=1.95 ?g/ml), Staphylococcus aureus JC-1 (MIC=7.8 ?g/ml), Micrococcus luteus Ml 11 (MIC=10 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17049601 Dev Comp Immunol. 2007;31(5):441-455. "Jiravanichpaisal P, Lee SY, Kim YA, Andrn T, S?derh?ll I." Antibacterial peptides in hemocytes and hematopoietic tissue from freshwater crayfish Pacifastacus leniusculus: characterization and expression pattern. DRAMP02391 GWFKKAWRKVKHAGRRVLDTAKGVGRHYLNNWLNRYRG 38 "Hematopoietic antimicrobial peptide-37 (MgCath37; hagfishes, chordates, animals)" Q71MD7 Not found CATH37 Myxine glutinosa (Atlantic hagfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Propionibacterium acnes ATCC 11827 and 33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081 and 13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771, 43935, 12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15019197 Peptides. 2003 Nov;24(11):1655-1667. "Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M." Hagfish intestinal antimicrobial peptides are ancient cathelicidins. DRAMP02393 GFFKKAWRKVKHAGRRVLDTAKGVGRHYVNNWLNRYRZ 38 "HFIAP-1 (HFIAP-2; hagfishes, chordates, animals)" No entry found Not found Not found Myxine glutinosa (Atlantic hagfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species. Sequence similarity: Sequences for HFIAP-1 and -2 are identical, but HFIAP-2 is brominated only at residue 7; they differ from MgCath37 by conservative replacements." "Gram-positive bacteria: Propionibacterium acnes ATCC 11827/33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081/13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771/43935/12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15019197 Peptides. 2003 Nov;24(11):1655-1667. "Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M." Hagfish intestinal antimicrobial peptides are ancient cathelicidins. DRAMP02394 GWFKKAWRKVKNAGRRVLKGVGIHYGVGLIZ 31 "HFIAP-3 (hagfishes, chordates, animals)" No entry found Not found Not found Myxine glutinosa (Atlantic hagfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species. HFIAP-1 and HFIAP-3 exhibit similar inhibitory activity. "Gram-positive bacteria: Propionibacterium acnes ATCC 11827/33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081/13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771/43935/12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15019197 Peptides. 2003 Nov;24(11):1655-1667. "Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M." Hagfish intestinal antimicrobial peptides are ancient cathelicidins. DRAMP02395 AACSDRAHGHICESFKSFCKDSGRNGVKLRANCKKTCGLC 40 "Aurelin (jellyfish, chordates, animals)" "Q0MWV8, P84891" Belongs to ShKT domain family Not found Aurelia aurita (Moon jellyfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Combine helix and strand structure Not found 2LG4 resolved by NMR. "Function: Antimicrobial peptide exhibits activity against Gram-positive and Gram-negative bacteria. Domian: Contains 1 ShKT domain. PTM: Contains three disulfide bonds (By similarity)." Gram-positive bacterium: Listeria monocytogenes EGD (MIC=22.64 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35p (MIC=7.66 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys19 and Cys40) Disulfide bonds between Cys3 and Cys33; Cys12 and Cys37; Cys19 and Cys40. L No cytotoxicity information found Not found 16890198##PubMed ID is not available Biochem Biophys Res Commun. 2006 Sep 22;348(2):514-523.##To be Published. "Ovchinnikova TV, Balandin SV, Aleshina GM, Tagaev AA, Leonova YF, Krasnodembsky ED, Men'shenin AV, Kokryakov VN.##Shenkarev Z, Altukhov D, Gizatullina A, Arseniev A, Ovchinnikova T." "Aurelin, a novel antimicrobial peptide from jellyfish Aurelia aurita with structural features of defensins and channel-blocking toxins.##Solution structure of aurelin, a novel antimicrobial peptide." DRAMP02397 AVPDVAFNAYG 11 Big defensin (RPD-1) P86316 Belongs to the big defensin family Not found Venerupis philippinarum (Japanese carpet shell) (Tapes japonica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro. Has antibacterial activity. "Gram-positive bacteria: Staphylococcus aureus (MIC=9.6 mg/L), Bacillus subtilis (MIC=76.8 mg/L), Micrococcus tetragenus (MIC=38.4 mg/L);##Gram-negative bacteria: Escherichia coli (MIC=76.8 mg/L), Vibrio parahaemolyticus (MIC=19.2 mg/L), Vibrio anguillarum (MIC=19.2 mg/L)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14673509 Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Dec;35(12):1145-8. "Wei YX, Guo DS, Li RG, Chen HW, Chen PX." Purification of a big defensin from Ruditapes philippinesis and its antibacterial activity. DRAMP02402 FLPKMSTKLRVPYRRGTKDYH 21 Antimicrobial peptide scolopin-1 P0CH48 Not found Not found Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide against both Gram-positive, Gram-positive and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells. Tissue specificity: Expressed by the venom gland." "[Ref.19716842]Gram-negative bacteria: Escherichia coli standard strain (MIC=12.5 ?g/ml), E. coli drug-resistant strain (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=1.2 ?g/ml), S. aureus drug-resistant strain (MIC=5.0 ?g/ml), Bacillus dysenteriae standard and drug-resistant strains (MIC=7.5 ?g/ml);##Yeast: Candida albicans (MIC=15 ?g/ml)." [Ref.19716842]25 2% hemolytic activity at 50 g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19716842 Toxicon. 2010 Feb-Mar;55(2-3):274-279. "Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H." Two novel antimicrobial peptides from centipede venoms. DRAMP02403 GILKKFMLHRGTKVYKMRTLSKRSH 25 Antimicrobial peptide scolopin-2 P0CH49 Not found Not found Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide against both Gram-positive, -negative and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells. Tissue specificity: Expressed by the venom gland." "[Ref.19716842]Gram-negative bacteria: Escherichia coli standard and drug-resistant strains (MIC=5.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=0.5 ?g/ml), S. aureus drug-resistant strain (MIC=1.0 ?g/ml), Bacillus dysenteriae standard strain (MIC=2.5 ?g/ml), B. dysenteriae drug-resistant strain (MIC=5.0 ?g/ml);##Yeast: Candida albicans (MIC=7.5 ?g/ml)." [Ref.19716842]32 7% hemolytic activity at 50 g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19716842 Toxicon. 2010 Feb-Mar;55(2-3):274-279. "Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H." Two novel antimicrobial peptides from centipede venoms. DRAMP02409 GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF 34 M-theraphotoxin-Gr1a (M-TRTX-Gr1a; GsMTx-4) "Q7YT39, Q7M3T1" Belongs to the huwentoxin-1 family Not found Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Beta strand (5 strands; 9 residues) Not found "1LU8, 1TYK resolved by NMR." "Function: This cationic hydrophobic peptide inhibits a lot of different channels and has an antimicrobial activity. It blocks mechanosensitive ion channels (also named stretch-activated channels or SACs), without having effect on whole-cell voltage-sensitive currents. Acts by partitioning into the membrane and perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. Inhibits atrial fibrillation as well as the membrane motor of outer hair cells at low doses. GsMTx-4 exhibites antimicrobial properties and was more active against Gram-positive than Gram-negative bacteria. Tissue specificity: Expressed by the venom gland. Miscellaneous: This toxin does not inhibit potassium channels Kv1.1/KCNA1 (IC50>85 ?M), Kv1.4/KCNA4 (IC50>85 ?M) and Kv11.3/KCNH7 (IC50=53 ?M). PTM: Contains three disulfide bonds." "Gram-positive bacteria: Bacillus subtilis (MIC=0.5 ?M), Staphylococcus aureus (MIC=2-4 ?M), Staphylococcus epidermidis (MIC=4-8 ?M);##Gram-negative bacteria: Salmonella typhimurium (MIC=32.64 ?M), Pseudomonas aeruginosa (MIC=8-16 ?M), Escherichia coli (MIC=8-16 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys17,Cys9 and Cys23,Cys16 and Cys30." L No cytotoxicity information found Not found PubMed ID is not available##12082099##10779316##163768 Submitted (MAY-2002) to the PDB data bank##J Biol Chem. 2002 Sep 13;277(37):34443-50.##J Gen Physiol. 2000 May;115(5):583-598.##Biochem Biophys Res Commun. 2006 Feb 10;340(2):633-638. "Jung HJ, Lee CW, Earm YE, Kim JI.##Oswald RE, Suchyna TM, McFeeters R, Gottlieb P, Sachs F.##Suchyna TM, Johnson JH, Hamer K, Leykam JF, Gage DA, Clemo HF, Baumgarten CM, Sachs F.##Jung HJ, Kim PI, Lee SK, Lee CW, Eu YJ, Lee DG, Earm YE, Kim JI." "Solution structure of GsMTx-4, a peptide blocker of cation-selective stretch-activated channels.##Solution structure of peptide toxins that block mechanosensitive ion channels.##Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.##Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel." DRAMP02410 FSKYERQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIKWNEEGLPIYEIPGEGGHAEPAAA 62 Antimicrobial peptide lumbricin-1 O96447 Not found Not found Lumbricus rubellus (Humus earthworm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Displays antimicrobial activity and weak hemolytic activity. Developmental stage: Adult-specific. Not detected in eggs or 1-week-old worms but abundant in 6-month-old worms. Induction: Constitutively expressed. Not induced by bacterial infection." "[Ref.9784609]Gram-positive bacteria: Bacillus subtilis ATCC 62037 (MIC=12 ?g/ml), Staphylococcus aureus ATCC 15752 (MIC=16 ?g/ml), Streptococcus mutans ATCC 25175 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 27325 (MIC=12 ?g/ml), Pseudomonas putidaATCC 17426 (MIC=16 ?g/ml), Serratia sp. ATCC 21074 (MIC=16 ?g/ml);##Fungi: Candida albicans ATCC 10231 (MIC=16 ?g/ml), Cryptococcus neoformance ATCC 34881 (MIC=25 ?g/ml), Saccharomyces cerevisiae ATCC 44774 (MIC=12 ?g/ml).##NOTE: Minimal inhibitory concentrations were determined by incubating approximately 104C105 CFU/ml of cells with serial dilutions of each peptide in a 96-well microtiter plate." "[Ref.9784609]0.02% hemolytic activity at 5 g/ml, 0.06% hemolytic activity at 10 g/ml, 0.14% hemolytic activity at 25 g/ml, 0.19% hemolytic activity at 50 g/ml, 0.23% hemolytic activity at 100 g/ml against human erythrocytes " Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784609 Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76. "Cho JH, Park CB, Yoon YG, Kim SC." "Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization." DRAMP02411 GHLGRPYIGGGGGFNRGGGFHRGGGFHRGGGFHSGGGFHRGGGFHSGGSFGYR 53 Armadillidin (Glyc-rich) Q64HC7 Not found Not found Armadillidium vulgare (Pillbug) (Pill woodlouse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium B. megaterium LM101. Tissue specificity: Expressed in hemocytes and at very low levels in ovary. Not expressed in adipose tissue, brain, caecum, gut, heart and nervous chain. PTM C-terminal amidation." "Gram-positive bacteria: Bacillus megaterium LM101 (MIC=0.5-1.25 ?M), Enterococcus faecalis LM002, Micrococcus luteus LM610, Listeria ivanovii BUG496;##Gram-negative bacteria: Escherichia coli JM83, Salmonella thyphimurium LM122, Enterobacter cloacae LM111, Citrobacter freundii LM457.##NOTE: Because of the low amount of the purified peptide, this minimal concentration activity is only tested on B. megaterium." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15752546 Dev Comp Immunol. 2005;29(6):489-499. "Herbinire J, Braquart-Varnier C, Grve P, Strub JM, Frre J, Van Dorsselaer A, Martin G." "Armadillidin: a novel glycine-rich antibacterial peptide directed against Gram-positive bacteria in the woodlouse Armadillidium vulgare (terrestrial isopod, crustacean)." DRAMP02412 SYVGDCGSNGGSCVSSYCPYGNRLNYFCPLGRTCCRHAYV 40 "Panusin (Defensin-like peptide 7, PaD7) " F6KSI8 Belongs to the beta-defensin family Not found Panulirus argus (Caribbean spiny lobster) (Palinurus argus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Has antibacterial activity. PTM: Contains two disulfide bonds (By similarity)." Gram-positive bacterium: Staphylococcus aureus ATCC 29737 (MIC=3.46 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=4.8 ?M). [Ref.27616720] It shows no hemolytic effect on human red blood cells Cyclic Free Free "Disulfide bonds between Cys6 and Cys28,Cys13 and Cys34,Cys18 and Cys35." L No cytotoxicity information found Not found 22885029##PubMed ID is not available Fish Shellfish Immunol. 2012 Oct;33(4):872-879.##Submitted (FEB-2012) to UniProtKB "Montero-Alejo V, Acosta-Alba J, Perdomo-Morales R, Perera E, Hernndez-Rodrguez EW, Estrada MP, Porto-Verdecia M.##Montero-Alejo V, Pacios-Michelena A, Perdomo-Morales R, Crozo G, Vega-Hurtado Y." "Defensin like peptide from Panulirus argus relates structurally with beta defensin from vertebrates.##Panusin, a new defensin-like antimicrobial peptide from the hemocytes of spiny lobster Panulirus argus." DRAMP02421 ACHAHCQSVGRRGGYCGNFRMTCYCY 26 "Hlgut-defensin (H. longicornis midgut defensin; Ticks, Arthropods, animals)" A4GUC3 Not found Not found Haemaphysalis longicornis (Bush tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Not found Not found None "Function: Both Hlgut-defensin and Hlsal-defensin sequences have antibactrrial activity against a variety of Gram-positive and Gram-negative bacteria. Induction: By a lipopolysaccharide (LPS) injection." Gram-positive bacterium: Staphylococcus aureus (MIC=5-25 mg/mL);##Gram-negative bacterium: Escherichia coli (MIC=10-25 mg/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17521774 Peptides. 2007 Jun;28(6):1304-1310. "Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K." Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis. DRAMP02422 NCIQQCVSKGAQGGYCTNEKCTCY 24 "Hlsal-defensin (H. longicornis salivary gland defensin; Ticks, Arthropods, animals)" A4GUC4 Not found Not found Haemaphysalis longicornis (Bush tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Not found Not found None "Function: Both Hlgut-defensin and Hlsal-defensin sequences have antibactrrial activity against a variety of Gram-positive and Gram-negative bacteria. Induction: By a lipopolysaccharide (LPS) injection." Gram-positive bacterium: Staphylococcus aureus (MIC=5-25 mg/mL);##Gram-negative bacterium: Escherichia coli (MIC=10-25 mg/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17521774 Peptides. 2007 Jun;28(6):1304-1310. "Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K." Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis. DRAMP02423 DFGCARGMIFVCMRRCARMYPGSTGYCQGFRCMCDTMIPIRRPPFIMG 48 "HlMS-defensin (Ticks, Arthropods, animals)" No entry found Not found Not found Haemaphysalis longicornis (Tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=18.8 ?g/ml), Bacillus licheniformis (MIC=9.4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=28.1 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=37.5 ?g/ml), Serratia rubidaea (MIC=28.1 ?g/ml), Psychrobacter faecalis (MIC=2.3 ?g/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22033149 Dev Comp Immunol. 2012 May;37(1):207-211. "Zheng H, Zhou L, Yang X, Wang D, Liu J." Cloning and characterization of a male-specific defensin-like antimicrobial peptide from the tick Haemaphysalis longicornis. DRAMP02425 QLKVDLWGTRSGIQPEQHSSGKSDVRRWRSRY 32 "Ixosin-B (Ticks, Arthropods, animals)" A7UDM9 Not found Not found Ixodes sinensis (Hard tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antifungal and antibacterial activity. Ixosin-B has little hemolytic activity on red blood cells even with peptide concentrations up to 200 ?g/mL." [Ref.18295522]Gram-positive bacterium: Staphylococcus aureus (MIC=2.5 ?g/mL);##Gram-negative bacterium: Escherichia coli (MIC=15 ?g/mL);##Yeast: Candida albicans (MIC=7.5 ?g/mL). [Ref.18295522]Little hemolytic activity on rabbit red blood cells up to 200 g/mL Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18295522 Comp Biochem Physiol B Biochem Mol Biol. 2008 Apr;149(4):557-561. "Liu Z, Liu H, Liu X, Wu X." "Purification and cloning of a novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis." DRAMP02430 GLHKVMREVLGYERNSYKKFFLR 23 "Ixosin (Ticks, Arthropods, animals)" Q2LKX9 Not found Not found Ixodes sinensis (Hard tick) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antifungal activity against C. albicans. Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Little hemolytic activity against rabbit erythrocytes. [Ref.16087274]Gram-postive bacteria: Staphylococcus aureus (MIC=3.7 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=30 ?g/ml);##Fungi: Candida albicans (MIC=7.5 ?g/ml). [Ref.16087274]Little hemolytic activity on rabbit red blood cells up to 50 g/mL Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16087274 Peptides. 2006 Jan;27(1):31-5. "Yu D, Sheng Z, Xu X, Li J, Yang H, Liu Z, Rees HH, Lai R." "A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis." DRAMP02432 PDPGQPWQVKAGRPPCYSIPCRKHDECRVGSCSRCNNGLWGDRTCR 46 "Antimicrobial peptide ISAMP (Ticks, Arthropods, animals)" Q8MVA6 Not found Not found Ixodes scapularis (Black-legged tick) (Deer tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial activity and weak hemolytic. Tissue specificity: Expressed in the fat body, hemocytes and salivary glands of partially-fed female ticks. Not expressed in the midgut." "[Ref.19852941]Gram-positive bacteria: Bacillus cereus (MIC=5.8 ?g/ml), Bacillus subtilis (MIC=12.3 ?g/ml), Staphylococcus aureus (MIC=10.4 ?g/ml);##Gram-negative bacteria: Escherichia coli Edl 933 (MIC=3.2 ?g/ml), E. coli MG/655 (MIC=4.2 ?g/ml)." [Ref.19852941]Insignificant hemolytic activity even up to 150 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12177149##19852941 J Exp Biol. 2002 Sep;205(Pt 18):2843-2864.##Biochem Biophys Res Commun. 2009 Dec 18;390(3):511-515. "Valenzuela JG, Francischetti IM, Pham VM, Garfield MK, Mather TN, Ribeiro JM.##Pichu S, Ribeiro JM, Mather TN." "Exploring the sialome of the tick Ixodes scapularis.##Purification and characterization of a novel salivary antimicrobial peptide from the tick, Ixodes scapularis." DRAMP02434 FSRYARMRDSRPWSDRKNNYSGPQFTYPPEKAPPEKLIKWNNEGSPIFEMPAEGGHIEP 59 Antimicrobial peptide lumbricin-PG (Lumbricin-PG) P86929 Not found Not found Pheretima guillelmi (Earthworm) (Metaphire guillelmi) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Displays stronger activity against P. aeruginosa and S. aureus than E. coli. At the concentration of 200 g/ml, it induces 1.5 and 2.1% hemolysis of human and rabbit red blood cells, respectively." "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=2.5 ?g/m).##Fungi: Candida albicans ATCC 2002." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21539875 Peptides. 2011 Jun;32(6):1146-1150. "Li W, Li S, Zhong J, Zhu Z, Liu J, Wang W." "A novel antimicrobial peptide from skin secretions of the earthworm, Pheretima guillelmi (Michaelsen)." DRAMP02445 LYKLVKVVLNM 11 Antimicrobial protein BL-A60 B3EWC5 Not found Not found Brevibacillus laterosporus (Bacillus laterosporus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. In P.capsici, inhibits mycelial growth (EC50=7.89 ?g/ml), formation of sporangia (EC50=0.6 ?g/ml) and cytospore germination (EC50=21.96 ?g/ml). PTM: Contains a choline moiety at the N-terminus and a tenuazonic acid moiety at the C-terminus. Biophysicochemical properties: pH dependence (Active between pH 3 and 11); Temperature dependence (Retains >80% activity after 15 min at 100 degrees Celsius)." "Gram-negative bacterium: Pseudomonas solanacearum (MIC=10 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=5 ?M).##Fungi: Phytophthora capsici (MIC=15 ?M), Botrytis cinerea (MIC=25 ?M), Verticillium dahliae (MIC=200 ?M), Fusarium oxysporum (MIC=50 ?M), Xerocomus vesicolor (MIC=100 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22244810 Peptides. 2012 Feb;33(2):206-211. "Zhao J, Guo L, Zeng H, Yang X, Yuan J, Shi H, Xiong Y, Chen M, Han L, Qiu D." Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60. DRAMP02446 YSKSLPLSVLNP 12 Antimicrobial protein 1 (Antimicrobial protein AN5-1) B3EWQ6 Not found Not found Paenibacillus alvei (Bacillus alvei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has a broad inhibitory spectrum against both Gram-positive and -negative bacterial strains. Miscellaneous: A synthetic peptide has no antibacterial activity against S. agalactiae ATCC 12386, S. epidermidis, P. aeruginosa and methicillin-resistant S. aureus (MRSA). Biophysicochemical properties: pH dependence (Active between pH 2 and 12); Temperature dependence (Active between 37 and 90 degrees Celsius. Activity is reduced at 100 degrees Celsius and absent at 110 degrees Celsius. Activity is unaffected by storage at -20 degrees Celsius)." "Gram-positive bacteria: Lactobacillus plantarum strain ATCC 8014 (MIC=32 ?g/ml), Lactococcus lactis ATCC 11454 (MIC>128 ?g/ml), Bacillus cereus strain ATCC 14579 (MIC=64 ?g/ml), Staphylococcus aureus (MIC=64 ?g/ml), Bacillus subtilis (MIC=32 ?g/ml), Bacillus anthracis (MIC=128 ?g/ml) and Bacillus licheniformis (MIC>128 ?g/ml), Bacillus ?exus (MIC=32 ?g/ml);##Gram-negative bacteria: Escherichia coli strain ATCC 13076 (MIC=8 ?g/ml), Salmonella enteritidis ATCC 13076 (MIC=4 ?g/ml), Enterobacter spp. (MIC=16 ?g/ml), Serratia marcescens (MIC=32 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23508455 J Ind Microbiol Biotechnol. 2013 Jun;40(6):571-579. "Alkotaini B, Anuar N, Kadhum AA, Sani AA." Detection of secreted antimicrobial peptides isolated from cell-free culture supernatant of Paenibacillus alvei AN5. DRAMP02470 SCTTCECCCSCS 12 Nosiheptide (NOS; Antibiotic 9671-RP) C6FX52 Belongs to the thiocillin family nosM Streptomyces actuosus "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Inhibits bacterial protein biosynthesis by binding to ribosomes. Specifically, binds to the complex of 23S rRNA and ribosomal protein L11 (RPLK) in the 50S ribosomal subunit. While allowing a weak binding of elongation factor G (EF-G) to the ribosome and subsequent GTP-hydrolysis, probably impairs conformational changes in both the ribosome and EF-G which are necessary for translocation. In vitro, inhibits a variety of Gram-positive bacteria and inhibits Gram-negative bacterium P. multocida strain A125 (MIC=0.0024 ?g/ml). Does not inhibit Gram-negative bacterium E. coli strain ATCC 9637 but does inhibit purified ribosomes from E. coli. In vivo, has no systemic effect in mice infected with staphylococci or streptococci when applied orally or subcutaneously. Has a local effect in mice infected subcutaneously or intraperitoneally with staphylococci when applied immediately afterwards. Is not toxic to mice. Miscellaneous: The mature peptide is identical to multhiomycin from S. antibioticus strain 8446CC1 (PMID 681244). Used as an antibiotic growth promotant in poultry and pig farming in parts of Asia." "Gram-positive bacteria: Staphylococcus aureus strain 209P (MIC=0.0009 ?g/ml), S. aureus strain 133 (MIC=0.0019 ?g/ml), S. aureus strain B3 (MIC=0.003 ?g/ml), S. aureus strain Hb (MIC=0.003 ?g/ml), Micrococcus citreus strain ATCC 8411 (MIC=0.0038 ?g/ml), M. lysodeikticus strain ATCC 4698 (MIC=0.003 ?g/ml), Sarcina Lutea strain ATCC 9341 (MIC=0.0011 ?g/ml), Streptococcus faecalis strain ATCC 9790 (MIC=0.0007 ?g/ml), S. viridans (MIC=0.0065 ?g/ml), Streptococcus pyogenes hemolyticus strain Dig7 (MIC=0.00028 ?g/ml), Diplococcus pneumoniae strain Til (MIC=0.00015 ?g/ml), N. catrrhalis (MIC=0.0017 ?g/ml), Lactobacillus casei strain ATCC 6633 (MIC=0.003 ?g/ml), Bacillus cereus ATCC 6630 (MIC=0.0071 ?g/ml) and various isolates of Listeria monocytogenes.##Gram-negative bacterium: P. multocida strain A125 (MIC=0.0024 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19678698##18406324 ACS Chem Biol. 2009 Oct 16;4(10):855-864.##Mol Cell. 2008 Apr 11;30(1):26-38. "Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W.##Harms JM, Wilson DN, Schluenzen F, Connell SR, Stachelhaus T, Zaborowska Z, Spahn CM, Fucini P." Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.##Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. DRAMP02473 KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF 30 "Cathelicidin-BF (Cathelicidin-related protein; Snakes, reptiles, animals)" B6D434 Not found Not found Bungarus fasciatus (Banded krait) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane. No hemolytic and cytotoxic activities have been observed on mammalian cells. Tissue specificity: Expressed by the venom gland, stomach, trachea, skin, muscle, heart, kidney, lung, brain, intestine, spleen, liver, and ovary. Miscellaneous: A predicted cleavage site is located at position Val-157-158-Lys, giving a peptide of 34 residues instead of the 30 residues found for the purified protein. The 30 residues cathelicidin-BF could result from a further processing." "[Ref.18795096]Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=1.2 ?g/ml), P. aeruginosa IS/DR (MIC=2.3 ?g/ml), P. aeruginosa 08031205 IS/DR (MIC=9.4 ?g/ml), P. aeruginosa 08031014 IS/DR (MIC=18.7 ?g/ml), Escherichia coli ATCC25922 (MIC=2.3 ?g/ml), E. coli 08A852 IS/DR (MIC=1.2 ?g/ml), E. coli 08A866 IS/DR (MIC=0.6 ?g/ml), E. coli 08031017 IS/DR (MIC=2.3 ?g/ml), E. coli 08032813 IS/DR (MIC=2.3 ?g/ml), E. coli 08040726 IS/DR (MIC=0.6 ?g/ml), E. coli 08040722 IS/DR (MIC=0.6 ?g/ml), Klebsiella pneumoniae IS/DR (MIC=4.7 ?g/ml), K. pneumoniae 08031012 IS/DR (MIC=9.4 ?g/ml), K. pneumoniae 08040202 IS/DR (MIC=0.6 ?g/ml), K. pneumoniae 08040724 IS/DR (MIC=0.3 ?g/ml), Pseudomonas luteola (MIC=1.2 ?g/ml), Salmonella Typhi IS/DR (MIC=1.2 ?g/ml), Acinetobacter calcoaceticus (MIC=2.3 ?g/ml), Sphingobacterium siyangense (MIC=9.4 ?g/ml), Saccharibacillus kuerlensis (MIC=4.7 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=9.4 ?g/ml), B. pumilus (MIC=9.4 ?g/ml), B. cereus (MIC=1.2 ?g/ml), Staphylococcus aureus ATCC2592 (MIC=4.7 ?g/ml), S. aureus 08A875 IS/DR (MIC=75 ?g/ml), S. aureus 08031002 IS/DR (MIC>100 ?g/ml), S. aureus 08031013 IS/DR (MIC>100 ?g/ml), S. aureus 08032706 IS/DR (MIC>100 ?g/ml), S. aureus 08032712 IS/DR (MIC>100 ?g/ml), S. aureus 08032810 IS/DR (MIC>100 ?g/ml), Enterococcus faecium IS/DR (MIC=150 ?g/ml);##Fungi: Aspergillus terreus GIM3.34 (MIC=18.7 ?g/ml), Aspergillus nidulans (MIC=18.7 ?g/ml), Candida albicans ATCC2002 (MIC=4.7 ?g/ml), Pichia pastoris (MIC=0.3 ?g/ml)." [Ref.18795096]Non-hemolytic activity at 400 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 18795096##18620012 PLoS One. 2008 Sep 16;3(9):e3217.##Peptides. 2008 Oct;29(10):1685-1691. "Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R.##Zhao H, Gan TX, Liu XD, Jin Y, Lee WH, Shen JH, Zhang Y." Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics.##Identification and characterization of novel reptile cathelicidins from elapid snakes. DRAMP02474 KFFRKLKKSVKKRAK 15 "cathelicidin-BF15 (Snakes, reptiles, animals)" B6D434 Not found Not found Bungarus fasciatus (Banded krait) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=4.7 ?g/ml), P. aeruginosa IS/DR (MIC=37.5 ?g/ml), P. aeruginosa 08031205 IS/DR (MIC=18.7 ?g/ml), P. aeruginosa 08031014 IS/DR (MIC=75 ?g/ml), Escherichia coli ATCC25922 (MIC=18.7 ?g/ml), E. coli 08A852 IS/DR (MIC=18.7 ?g/ml), E. coli 08A866 IS/DR (MIC=18.7 ?g/ml), E. coli 08031017 IS/DR (MIC=37.5 ?g/ml), E. coli 08040722 IS/DR (MIC=9.4 ?g/ml), K. pneumoniae 08040202 IS/DR (MIC=75 ?g/ml), Salmonella Typhi IS/DR (MIC=1.2 ?g/ml), Saccharibacillus kuerlensis (MIC=4.7 ?g/ml).##Gram-positive bacteria: Bacillus subtilis (MIC=75 ?g/ml), Staphylococcus aureus ATCC2592 (MIC=75 ?g/ml), S. aureus 08A875 IS/DR (MIC=75 ?g/ml), S. aureus 08031002 IS/DR (MIC>100 ?g/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.7 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18795096 PLoS One. 2008 Sep 16;3(9):e3217. "Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R." Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. DRAMP02478 IKFEPPLPPKKAHKKFWEDDGIYYPPNHNFP 31 "L-amino-acid oxidase (Bm-LAO; LAAO; LAO; Snakes, reptiles, animals)" B3EWI9 Belongs to the flavin monoamine oxidase family (FIG1 subfamily) Not found Bothropoides matogrossensis (Pitviper) (Bothrops neuwiedimatogrossensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic" Protein level Not found Not found None "Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). Tissue specificity: Expressed by the venom gland." "Gram-positive bacteria: Bacillus subtilis strain ATCC 6633 (MIC=32 ?M), Enterococcus faecalis strain ATCC 12953 (MIC=32 ?M), Staphylococcus aureus strain ATCC 29213 (MIC=32 ?M), Streptococcus pyogenes strain ATCC 19615 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli strain ATCC 8739 (MIC=4 ?M), Klebsiella pneumoniaee strain ATCC 13885 (MIC=2 ?M), Proteus mirabilis strain ATCC 25933 (MIC=2 ?M), Pseudomonas aeruginosa strain ATCC 15442 (MIC=8 ?M), Salmonella typhimurium strain ATCC 14028 (MIC=8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22438972 PLoS One. 2012;7(3):e33639. "Okubo BM, Silva ON, Migliolo L, Gomes DG, Porto WF, Batista CL, Ramos CS, Holanda HH, Dias SC, Franco OL, Moreno SE." Evaluation of an antimicrobial L-amino acid oxidase and peptide derivatives from Bothropoides mattogrosensis pitviper venom. DRAMP02520 KRFKKFFKKLKNSVKKRAKKFFKKPRVIGVSIPF 34 "OH-CATH (Snakes, reptiles, animals)" No entry found Not found Not found Ophiophagus hannah (King cobra) (Naja hannah) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 ?g/ml), E. coli ML-35P (MIC=6 ?g/ml), E. coli clinic strain (MIC=20 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?g/ml), Pseudomonas aeruginosa PA 01 (MIC=2 ?g/ml), Pseudomonas aeruginosa clinic strain (MIC=2 ?g/ml), Enterobacter aerogenes clinic strain (MIC=2 ?g/ml), E. cloacae clinic strain (MIC=1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18620012 Peptides. 2008 Oct;29(10):1685-1691. "Zhao H, Gan TX, Liu XD, Jin Y, Lee WH, Shen JH, Zhang Y." Identification and characterization of novel reptile cathelicidins from elapid snakes. DRAMP02522 HVINLEESFQEPEYENHLA 19 "L-amino-acid oxidase (LAAO, LAO, Oh-LAAO; Snakes, reptiles, animals)" "P81383, A8QL50" Not found Not found Ophiophagus hannah (King cobra) (Naja hannah) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: It binds to bacteria and shows antibacterial activities by generating hydrogen peroxide. Binding and antibacterial activities are higher against Gram-positive than against Gram-negative bacteria. May also have an ability to induce hemorrhage, hemolysis, edema, apoptosis. Tissue specificity: Expressed by the venom gland. Toxic dose: LD50 is 5 mg/kg by intravenous injection into mice. Temperature dependence: Exhibits unusual thermal stability. At pH 7.4, the enzyme retains full activity after incubation at 25 degrees Celsius for 30 days. Is stable at alkaline condition and is not inactivated by freezing." "Gram-negative bacteria: Klebsiella pneumonia (MIC=0.4 ?M), Pseudomonas aeruginosa (MIC=0.2 ?M), Escherichia coli (MIC=0.4 ?M), Escherichia coli ATCC 25922 (MIC=0.8 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=0.006 ?M), S. epidermidis (MIC=0.012 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Bacterial cell 9304806##2619759##2044840##7886693##21059402 Int J Biochem Cell Biol. 1997 Jun;29(6):911-919.##Biochem Int. 1989 Oct;19(4):937-944.##Int J Biochem. 1991;23(3):323-327.##Toxicon. 1994 Nov;32(11):1349-1358.##Comp Biochem Physiol C Toxicol Pharmacol. 2011 M "Ahn MY, Lee BM, Kim YS.##Tan NH, Saifuddin MN.##Tan NH, Saifuddin MN.##Li ZY, Yu TF, Lian EC.##Lee ML, Tan NH, Fung SY, Sekaran SD." Characterization and cytotoxicity of L-amino acid oxidase from the venom of king cobra (Ophiophagus hannah).##Isolation and characterization of an unusual form of L-amino acid oxidase from King cobra (Ophiophagus hannah) venom.##Substrate specificity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase.##Purification and characterization of L-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation.##Antibacterial action of a heat-stabl DRAMP02573 QVYKGGYTRPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS 62 "Penaeidin-3a (Pen-3a; shrimps, Arthropods, animals)" P81058 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity. Tissue specificity: Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain. Developmental stage: Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours. PTM: C-terminal amidation and contains three disulfide bonds 32-47; 36-54; 48-55." "Gram-positive bacteria: Aerococcus viridans (MIC=0.3-0.6 ?M), Micrococcus luteus (MIC=1.25-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Enterococcus fecalis (MIC>20 ?M), Saphylococcus aureus (MIC>40 ?M);##Gram-negative bacteria: Escherichia coli 363 (MI=10-20 ?M), Vibrio vulnificus (MIC>20 ?M), Salmonella thyphimurium (MIC>40 ?M), Klebsiella pneumoniae (MIC>40 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Neurospora crassa (MIC=1.25-2.5 ?M), Aspergillus fumigatus (MIC>20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic pyroglutamic acid Amidation "Disulfide bonds between Cys32 and Cys47,Cys36 and Cys54,Cys48 and Cys55. O-glycosylated on Thr8" L No cytotoxicity information found Chitin-binding 9353298##10561573##12842879 J Biol Chem. 1997 Nov 7;272(45):28398-28406.##Eur J Biochem. 1999 Dec;266(2):335-346.##J Biol Chem. 2003 Sep 19;278(38):36859-36867. "Destoumieux D, Bulet P, Loew D, Van Dorsselaer A, Rodriguez J, Bachre E.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bachre E.##Yang Y, Poncet J, Garnier J, Zatylny C, Bachre E, Aumelas A." "Penaeidins, a new family of antimicrobial peptides isolated from the shrimp Penaeus vannamei (Decapoda).##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp.##Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide." DRAMP02574 QVYKGGYARPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYSG 63 "[T8A]-Penaeidin-3a ([T8A]-Pen-3a; shrimps, Arthropods, animals)" P81058 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 11 residues) "[T8A]-Pen-3a structure consists of an unconstrained and a constrained part, which roughly match with the proline-rich (1-28 residues) and the cysteine-rich (29-58 residues) domains, respectively. The proline-rich domain does not adopt a constrained structure, whereas the cysteine-rich domain adopts a well-defined structure that consists of a helix (41-50 residues) tightly bound to the upstream (27-40 residues) and the downstream (51-63 " 1UEO resolved by NMR. "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity. PTM: Contains three disulfide bonds." "Gram-positive bacteria: Aerococcus viridans (MIC=0.4-0.8 ?M), Micrococcus luteus (MIC=0.8-1.6 ?M), Bacillus megaterium (MIC=3.12-6.25 ?M);##Gram-negative bacteria: Escherichia coli 363 (MI=3.12-6.25 ?M), Vibrio vulnificus (MIC>50 ?M), Salmonella thyphimurium (MIC>50 ?M), Klebsiella pneumoniae (MIC>50 ?M).##Fungi: Fusarium oxysporum (MIC=3.12-6.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic pyroglutamic acid Amidation "Disulfide bonds between Cys32 and Cys47,Cys36 and Cys54,Cys48 and Cys55. O-glycosylated on Thr8" L No cytotoxicity information found Not found 12842879 J Biol Chem. 2003 Sep 19;278(38):36859-36867. "Yang Y, Poncet J, Garnier J, Zatylny C, Bachre E, Aumelas A." "Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide." DRAMP02584 HSSGYTRPLPKPSRPIFIRPIGCDVCYGIPSSTARLCCFRYGDCCHR 47 "Penaeidin-4a (Pen-4a; shrimps, Arthropods, animals)" Q95NT0 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity (By similarity). PTM: Contains three disulfide bonds 23-37; 26-44; 38-45 and C-terminal amidation." "Gram-positive bacteria: Aerococcus viridans (MIC=1.9-2.92 ?M), Micrococcus luteus (MIC=1.9-2.92 ?M), Bacillus megaterium (MIC>50 ?M), Saphylococcus aureus (MIC>50 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC=22-33 ?M), Vibrio vulnificus (MIC>50 ?M), Salmonella thyphimurium (MIC>50 ?M), Klebsiella pneumoniae (MIC>50 ?M).##Fungi: Fusarium oxysporum (MIC=0.84-1.26 ?M), Botrytis cinerea (MIC=4.38-6.57 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation "Disulfide bonds between Cys23 and Cys37,Cys26 and Cys44,Cys38 and Cys45." L No cytotoxicity information found Chitin-binding 12242595##15084144 Immunogenetics. 2002 Sep;54(6):442-445.##Biochem J. 2004 Jul 1;381(Pt 1):79-86. "Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Cuthbertson BJ, Bullesbach EE, Fievet J, Bachre E, Gross PS." Diversity of the penaeidin antimicrobial peptides in two shrimp species.##A new class (penaeidin class 4) of antimicrobial peptides from the Atlantic white shrimp (Litopenaeus setiferus) exhibits target specificity and an independent proline-rich-domain function. DRAMP02586 QRGGFTGPIPRPPPHGRPPLGPICNACYRLSFSDVRICCNFLGKCCHLVK 50 "Penaeidin-2d (Pen-2d; shrimps, Arthropods, animals)" Q962A9 Belongs to the penaeidin family Not found Litopenaeus setiferus (Atlantic white shrimp) (Penaeus setiferus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity). Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of hemocytes and to a lesser." "Gram-positive bacteria: Aerococcus viridans (MIC=1.25-2.5 ?M), Micrococcus luteus (MIC=2.5-5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Enterococcus fecalis (MIC>20 ?M), Saphylococcus aureus (MIC>20 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC>40 ?M), Vibrio vulnificus (MIC>20 ?M), Salmonella thyphimurium (MIC>20 ?M), Klebsiella pneumoniae (MIC>20 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Neurospora crassa (MIC=2.5-5 ?M), Aspergillus fumigatus (MIC>20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 12242595##10561573 Immunogenetics. 2002 Sep;54(6):442-445.##Eur J Biochem. 1999 Dec;266(2):335-346. "Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bachre E." "Diversity of the penaeidin antimicrobial peptides in two shrimp species.##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp." DRAMP02603 AALRGALRAVARVGKAILPHVAIANPYVRTPYVHNNP 37 "Putative antimicrobial peptide A Northern Europe Heligoland (chordates, animals)" No entry found Not found Not found Ciona intestinalis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus megaterium (MIC=0.1 ?M), Bacillus subtilis (MIC=3.1 ?M), Staphylococcus aureus (MIC>25 ?M), Staphylococcus epidermidis (MIC=25 ?M).##Gram-negative bacteria: Escherichia coli K12 D31 (MIC=0.8 ?M), Y. enterocolitica (MIC=3.1 ?M), Klebsiella pneumoniae (MIC>25?M), Pseudomonas aeruginosa (MIC=12.5 ?M), Serratia marcescens(MIC>25 ?M).##Fungi: Candida albicans ATCC 10261 (MIC=6.3 ?M), Candida albicans SC 5314 (MIC=6.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17658598 Dev Comp Immunol. 2008;32(3):286-298. "Fedders H, Leippe M." A reverse search for antimicrobial peptides in Ciona intestinalis: identification of a gene family expressed in hemocytes and evaluation of activity. DRAMP02650 APIIRRIPYYPEVESDLRIVDCKRSEGFCQEYCNYLETQVGYCSKKKDACCLH 53 "Sperm associated antigen 11 isoform C (primates, mammals, animals)" No entry found Not found Not found Macaca mulatta (Rhesus monkey) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=50-100 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15229135 Biol Reprod. 2004 Nov;71(5):1453-1460. "Avellar MC, Honda L, Hamil KG, Yenugu S, Grossman G, Petrusz P, French FS, Hall SH." Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta). DRAMP02740 YDLSKNCRLRGGICYIGKCPRRFFRSGSCSRGNVCCLRFG 40 "TBD-1 (Turtle beta-defensin 1; Reptiles, animals)" P86253 Belongs to the beta-defensin family Not found Emys orbicularis (European pond turtle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against the Gram-positive bacteria methicillin-resistant S. aureus ATCC 33591 and L. monocytogenes EGD, the Gram-negative bacterium E. coli ML53p and the yeast C. albicans 820. Has no hemolytic activity towards human erythrocytes. PTM: Contains three disulfide bonds 7-35; 14-29; 19-36." "[Ref.19253295]Gram-negative bacterium (LS, HS): Escherichia coli ML35p (MIC=0.65, >20 ?mol/L);##Gram-positive bacteria: (LS, HS): Listeria monocytogenes EGD (MIC=0.65, >20 ?mol/L), Methicillin-resistant Staphylococcus aureus ATCC 33591 (MIC=5.6, >20 ?mol/L).##Yeast: Candida albicans (MIC=5.2, >20 ?mol/L).##NOTE: LS (low salt): 10 mmol/L sodium phosphate buffer (pH 7.4) and HS (high salt): 10 mmol/L sodium-phosphate buffer (pH 7.4), 0.1 mol/L sodium chloride." [Ref.19253295] It has no hemolytic activity against human erythrocytes up to 25 mmol/L Cyclic Free Free Disulfide bonds between Cys7 and Cys35; Cys14 and Cys29; Cys19 and Cys36. L No cytotoxicity information found Not found 19253295 Proteomics. 2009 Mar;9(5):1364-1373. "Stegemann C, Kolobov A Jr, Leonova YF, Knappe D, Shamova O, Ovchinnikova TV, Kokryakov VN, Hoffmann R." "Isolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles." DRAMP02768 GLGSVFGRLARILGRVIPKVAKKLGPKVAKVLPKVMKEAIPMAVEMAKSQEEQQPQ 56 "Pilosulin-1 (Myr b I; ants, insects, animals)" "Q07932, Q9TWC1" Belongs to the pilosulin family Not found Myrmecia banksi (Jack jumper ant) (Australian jumper ant) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. The synthesized peptide 57-76 shows a potent and broad spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, and also against the fungus C. albicans. Adopts an alpha-helical structure. Tissue specificity: Expressed by the venom gland. Allergenic properties: Causes an allergic reaction in human." "[Ref.9813247]Gram-positive bacteria: Micrococcus luteus (MIC=0.5 ?M), Enterococcus spp.I-11305b (MIC=2 ?M), Enterococcus spp. I-11054 (MIC=2 ?M), Staphylococcus simulans 22 (MIC=2 ?M), S. haemolyticus I-10925 (MIC=2 ?M), S. epidermidis LT1324 (MIC=2 ?M), S. aureuss 5185 (MI=2 ?M), S. aureuss methicillin-sensitive I-11574 (MIC=2 ?M), S. aureuss (MRSA) LT1338 (MIC=3 ?M), S. aureuss (MRSA) LT1334 (MIC=1.5 ?M);##Gram-negative bacteria: Citrobacter freundii I-11090 (MIC=2 ?M), Klebsiella pneumoniae I-10910 (MIC=2 ?M), Escherichia coli I-11276b (MIC=4 ?M), E. coli O-19592 (MIC=2 ?M), Stenotrophomonas maltophilia O-16451 (MIC=2 ?M), S. maltophila I-10717 (MIC=2 ?M), Pseudomonas aeruginosa 4991 (MIC=4 ?M), Pseudomonas aeruginosa I-10968 (MIC=4 ?M);##Fungi: Candida albicans I-11301 (MIC=4 ?M), Candida albicans I-11134 (MIC>4 ?M)." [Ref.9813247]Complete lysis in the presence of pilosulin 1 was obtained at a concentration of 40 M with evidence of partial lysis visible down to 1.25 M Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet IgE 9813247##9701394##15639237##8866004 Arch Biochem Biophys. 2005 Feb 15;434(2):358-364.##Cytometry. 1998 Aug 1;32(4):268-273.##Arch Biochem Biophys. 2005 Feb 15;434(2):358-364.##Biochem Mol Biol Int. 1996 Aug;39(5):877-885. "Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.##King MA, Wu QX, Donovan GR, Baldo BA.##Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.##Donovan GR, Street MD, Tetaz T, Smith AI, Alewood D, Alewood P, Sutherland SK, Baldo BA." Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.##Flow cytometric analysis of cell killing by the jumper ant venom peptide pilosulin 1.##Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.##Expression of jumper ant (Myrmecia pilosula) venom allergens: post-translational processing of allergen gene products. DRAMP02777 SLQPGAPNFPMPGSQLPTSITSNIEKQGPNTAATINAQHKTDRYDVGATWSKVIRGPGRSKPNWSIGGTYRW 72 "Rhinocerosin (Insects, animals)" O76145 Belongs to the coleoptericin family Not found Oryctes rhinoceros (Coconut rhinoceros beetle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has strong antibacterial activity against Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus but not against Pseudomonas aeruginosa." "Gram-positive bacteria: Staphylococcus aureus (MIC=1 ?g/ml), Streptococcus pyogenes (MIC=1 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9738915 Eur J Biochem. 1998 Aug 1;255(3):734-738. "Yang J, Yamamoto M, Ishibashi J, Taniai K, Yamakawa M." "Isolation, cDNA cloning and gene expression of an antibacterial protein from larvae of the coconut rhinoceros beetle, Oryctes rhinoceros." DRAMP01623 LIGPVLGLVGSALGGLLKKI 20 "Bombinin-H4 (bombinin H isomers; Frogs, amphibians, animals)" P82284 Belongs to the bombinin family Not found Bombina variegata (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, hemolytic against mammalian cells, Antifungal" Protein level Alpha helix "The epimerization reaction is incomplete, or, after racemization, the peptides still containing the L-amino acid in position 2 are partly degraded." None Function: Have antimicrobial activity. Have some hemolytic activity. [Ref.8223491] Gram-negative bacterium: Escherichia coli D21 (MIC=4.8 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.3 ?M). [Ref.8223491] Lethal concentration is 14.6 ?M against human red blood cell. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8223491 EMBO J. 1993; 12:4829-4832. "Mignogna G, Simmaco M, Kreil G, Barra D.1993" Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata. DRAMP02779 VTCDLLSFEAKGFAANHSICAAHCLAIGRKGGSCQNGVCVCRN 43 "Defensin-A (Defensin A; Insects, animals)" P83669 Belongs to the invertebrate defensin family (Type 1 subfamily) Not found Anomala cuprea (Cupreous chafer beetle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Strong activity against the Gram-positive bacteria M.luteus, B.megaterium and S. aureus. Reduced activity against Gram-positive bacterium B.subtilis and weak activity against Gram-negative bacterium X.japonicus. PTM: Problely contains three disulfide bonds 3-34; 20-39; 24-41." "Gram-positive bacteria: Bacillus megaterium (MIC=1.2-2.5 ?M), Bacillus subtilis (MIC>40 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Staphylococcus aureus (MIC=2.5-5 ?M).##Gram-negative bacteria: Enterobacter asbriae (MIC>40 ?M), Escherichia coli (MIC>40 ?M), Pseudomonas aeruginosa (MIC>40 ?M), Serratia marcescens (MIC>40 ?M), Xenorhabdus japonicus (MIC>40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys3 and Cys34; Cys20 and Cys39; Cys24 and Cys41. L No cytotoxicity information found Not found 11719071 Insect Biochem Mol Biol. 2001 Dec;32(1):75-84. Yamauchi H. "Two novel insect defensins from larvae of the cupreous chafer, Anomala cuprea: purification, amino acid sequences and antibacterial activity." DRAMP02780 VTCDLLSFEAKGFAANHSICAAHCLVIGRKGGACQNGVCVCRN 43 "Defensin-B (Defensin B; Insects, animals)" P83668 Belongs to the invertebrate defensin family (Type 1 subfamily) Not found Anomala cuprea (Cupreous chafer beetle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has antibacterial activity against Gram-positive bacteria and the Gram-negative bacterium X. japonicus. PTM: Problely contains three disulfide bonds 3-34; 20-39; 24-41." "Gram-positive bacteria: Bacillus megaterium (MIC=1.2-2.5 ?M), Bacillus subtilis (MIC=20-40 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Staphylococcus aureus (MIC=2.5-5 ?M);##Gram-negative bacterium: X. japonicus (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys3 and Cys34; Cys20 and Cys39; Cys24 and Cys41. L No cytotoxicity information found Not found 11719071 Insect Biochem Mol Biol. 2001 Dec;32(1):75-84. Yamauchi H. "Two novel insect defensins from larvae of the cupreous chafer, Anomala cuprea: purification, amino acid sequences and antibacterial activity." DRAMP02802 AREASKSLIGTASCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR 46 "Paneth cell-specific alpha-defensin 1 (DEFA1; horse defensin; houses, mammals, animals" A6YB85 Not found DEFA1 Equus caballus (Horse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found 2MXQ resolved by NMR. Function: Membrane permeabilization is at least an essential part of the peptide's mode of action. "Gram-negative bacteria: Escherichia coli [ATCC 11775 (MBC=0.4 ?M); ATCC 25922 (MBC=0.4 ?M); ATCC 35218 (MBC=0.4 ?M)], E. coli D31 (MBC=0.8 ?M), Pseudomonas aeruginosa ATCC 11440 (MBC=3 ?M);##Gram-positive bacteria: Staphylococcus aureus [ATCC 6538 (MBC=0.8 ?M); ATCC 12600 (MBC=1.5 ?M)], Staphylococcus epidermidis ATCC 14990 (MBC=1.5 ?M), Enterococcus faecalis ATCC 29212 (MBC=6.1 ?M), E. faecalis PEG 205 (wild-type) (MBC=3 ?M), Streptococcus pyogenes ATCC 12344 (MBC=0.8 ?M), Bacillus megaterium ATCC 14581 (MBC=0.2 ?M).##Yeast: Candida albicans ATCC 24433 (MIC=0.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys14 and Cys44; Cys16 and Cys32; Cys22 and Cys43. L No cytotoxicity information found Not found 17620056 Biochem J. 2007 Oct 15;407(2):267-276. "Bruhn O, Regenhard P, Michalek M, Paul S, Gelhaus C, Jung S, Thaller G, Podschun R, Leippe M, Gr?tzinger J, Kalm E." "A novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function." DRAMP02809 HPHVCTSYYCSKFCGTAGCTRYGCRNLHRGKLCFCLHCSR 40 "Myticin-B (Myt B; Cys-rich; molluscas, animals)" P82102 Not found Not found Mytilus galloprovincialis (Mediterranean mussel) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Rich Not found None "Function: Bacteriolytic activity against Gram-positive bacteria and Gram-negative bacteria. Also possesses antifungal activity against F. oxysporum. PTM: contains four disulfide bonds." "Gram-positive bacteria: Micrococcus luteus (MBC=1-2 ?M), Bacillus megaterium (MBC=1-2 ?M), Aerococcus viridans (MBC=2-4 ?M).##Gram-negative bacteria: Escherichia coli D31 (MBC=20-10 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free contains four disulfide bonds. L No cytotoxicity information found Not found 10491159 Eur J Biochem. 1999 Oct 1;265(1):71-78. "Mitta G, Hubert F, No?l T, Roch P." "Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis." DRAMP02811 GFGCPNNYQCHRHCKSIPGRCGGYCGGWHRLRCTCYRC 38 "Defensin MGD-1 (molluscas, animals)" "P80571, Q9Y0B0" Not found FH3 Mytilus galloprovincialis (Mediterranean mussel) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Combine helix and strand structure "The three-dimensional solution structure of MGD-1 has been established using (1)H NMR and mainly consists of a helical part (Asn7-Ser16) and two antiparallel beta-strands (Arg20-Cys25 and Cys33-Arg37), together giving rise to the common cystine-stabilized alpha-beta motif frequently observed in scorpion toxins. In MGD-1, the cystine-stabilized alpha-beta motif is stabilized by four disulfide bonds (Cys4-Cys25, Cys10-Cys33, Cys14-Cys35, " 1FJN resolved by NMR. "Function: Active against both Gram-positive and Gram-negative bacteria but is not cytotoxic towards human erythrocytes or protozoa. Transgenic plants: expression of this peptide in tobacco improves resistance to pathogens. PTM: Contains four disulfide bonds 4-25; 10-33; 14-35; 21-38." "Gram-positive bacteria: Micrococcus luteus (MIC=0.4 ?M)&(MBC=1.5 ?M), Bacillus megaterium (MIC=0.8 ?M)&(MBC=1.5 ?M), Staphylococcus aureus (MIC=0.6 ?M)&(MBC=1.2 ?M), Staphylococcus epidermidis (MIC=3.1 ?M)&(MBC=6.2 ?M), Enterococcus fecalis (MIC=0.6 ?M)&(MBC=1.2 ?M), Aerococcus viridans (MIC=0.4 ?M)&(MBC=1.5 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC=1.2 ?M)&(MBC=1.2 ?M), E. coli 363 (MIC=1.2 ?M)&(MBC=1.2 ?M), Salmonella newport (MIC>100 ?M)&(MBC>100 ?M), Vibrio alginolyticus (MIC=50 ?M)&(MBC>100 ?M), Vibrio harveyi (MIC=50 ?M)&(MBC=100 ?M), Vibrio metshnikovii (MIC>100 ?M)&(MBC>100 ?M).##NOTE: MIC=minimal inhibitory concentration; MBC = minimal bactericidal concentration." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bond between Cys4 and Cys25, Cys10 and Cys33, Cys14 and Cys35,Cys21 and Cys38." L No cytotoxicity information found Not found 10564642##8925841##11087396 J. Cell Sci. 1999;112:4233-4242.##Eur. J. Biochem. 1996;240:302-306.##Biochemistry 2000 Nov 28;39(47):14436-47. "Mitta G, Vandenbulcke F, Hubert F, Roch P.##Hubert F, Noeel T, Roch P.##Yang YS, Mitta G, Chavanieu A, Calas B, Sanchez JF, Roch P, Aumelas A." Mussel defensins are synthesised and processed in granulocytes then released into the plasma after bacterial challenge.##A member of the arthropod defensin family from edible Mediterranean mussels (Mytilus galloprovincialis).##Solution structure and activity of the synthetic four-disulfide bond Mediterranean mussel defensin (MGD-1). DRAMP02817 VDKGSYLPRPTPPRPIYNRN 20 Pyrrhocoricin "P37362, P80307" Belongs to the drosocin family Not found Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Combine helix and strand structure Not found 4EZN resolved by X-ray. "Function: Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis." "Gram-positive bacteria: Micrococcus luteus (MIC>80 ?M in L.B, P.B), Bacillus megaterium (MIC>80 ?M in L.B, P.B);##Gram-negative bacteria: Escherichia coliD22 (MIC=0.3 ?M in L.B, P.B), A.tumefaciens (MIC=1.25 ?M in LB and 3 ?M in PB), Salmonella typhimurium (MIC=5 ?M in L.B and 10 ?M in P.B)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10076062##8002963##23562829 Biochim Biophys Acta. 1999 Feb 2;1426(3):459-467.##Biochem J. 1994 Jun 1;300 (Pt 2):567-575.##J Mol Biol. 2013 Jul 24;425(14):2463-2479. "Hoffmann R, Bulet P, Urge L, Otv?s L Jr.##Cociancich S, Dupont A, Hegy G, Lanot R, Holder F, Hetru C, Hoffmann JA, Bulet P.##Zahn M, Berthold N, Kieslich B, Knappe D, Hoffmann R, Str?ter N." "Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects.##Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.##Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK." DRAMP01381 GLFTLIKGAAKLIGKTVPKKQARLGMNLWLVKLPTNVKT 39 "Odorranain-K1 (OdK1; Frogs, amphibians, animals)" A6MBN8 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-K1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 g/ml), Bacillus subtilis (MIC=1.10 g/ml).##Yeast: Candida albicans (MIC=1.10 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01383 ATAWDFGPHGLLPIRPIRIRPLCGKDKS 28 "Odorranain-M1 (OdM1; Frogs, amphibians, animals)" A6MBP6 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-M1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=9.37 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 g/ml), Bacillus subtilis (MIC=75 g/ml).##Yeast: Candida albicans (MIC=18.75 g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02841 RQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIK 34 Lumbricin I(6C34) O96447 Not found Not found Synthetic construct (derived from residues 6C34 of lumbricin I) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Lumbricin I(6-34) has marginally stronger antimicrobial activities than lumbricin I. Has weak hemolytic activity when tested against human erythrocytes. "[Ref.9784609]Gram-positive bacteria: Bacillus subtilis ATCC 62037 (MIC=8 ?g/ml), Staphylococcus aureus ATCC 15752 (MIC=12 ?g/ml), Streptococcus mutans ATCC 25175 (MIC=20 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 27325 (MIC=8 ?g/ml), Pseudomonas putidaATCC 17426 (MIC=12 ?g/ml), Serratia sp. ATCC 21074 (MIC=12 ?g/ml).##Fungi: Candida albicans ATCC 10231 (MIC=12 ?g/ml), Cryptococcus neoformance ATCC 34881 (MIC=16 ?g/ml), Saccharomyces cerevisiae ATCC 44774 (MIC=8 ?g/ml).##NOTE: Minimal inhibitory concentrations were determined by incubating approximately 104C105 CFU/ml of cells with serial dilutions of each peptide in a 96-well microtiter plate.." "[Ref.9784609]0.03% hemolytic activity at 5 g/ml, 0.07% hemolytic activity at 10 g/ml, 0.13% hemolytic activity at 25 g/ml, 0.17% hemolytic activity at 50 g/ml, 0.21% hemolytic activity at 100 g/ml against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784609 Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76. "Cho JH, Park CB, Yoon YG, Kim SC." "Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization." DRAMP02843 ILKKWPWWPWRRKX 14 "chain a, Structure Of An Indolicidin Peptide Derivative With" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Non helix or strand structure Not found 1QXQ resolved by NMR. Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=8 ?g/ml), Pseudomonas aeruginosa (MIC=16 ?g/ml), Salmonella typhimurium (MIC=64 ?g/ml), S. typhimurium defensin sensitive (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) (MIC=16 ?g/ml), S. epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11123901 Biochemistry. 2000 Dec 26;39(51):15765-15774. "Rozek A, Friedrich CL, Hancock RE." Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles. DRAMP02845 ICLKKWPWWPWRRCKX 16 "CP-11 (cathelicidin; mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Non helix or strand structure Not found 1QX9 resolved by NMR. Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=16 ?g/ml), Pseudomonas aeruginosa (MIC=64 ?g/ml), Salmonella typhimurium(MIC=64 ?g/ml), S. typhimurium defensin sensitive (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) (MIC=16 ?g/ml), S. epidermidis(MIC=8 ?g/ml), Enterococcus faecalis (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11123901##14640680 Biochemistry. 2000 Dec 26;39(51):15765-15774.##Biochemistry. 2003 Dec 9;42(48):14130-14138. "Rozek A, Friedrich CL, Hancock RE.##Rozek, A.; Powers, JP.; Friedrich, CL.; Hancock, RE. " Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.##Structure-based design of an indolicidin peptide analogue with increased protease stability. DRAMP02849 RFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLRFP 42 "Bactenecin 5 (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Salmonella typhimurium (MIC=2-10 ?M), Klebsiella pneumoniae, Escherichia coli." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2229048 J Biol Chem. 1990 Nov 5;265(31):18871-18874. "Frank RW, Gennaro R, Schneider K, Przybylski M, Romeo D." Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils. DRAMP02851 RLCRIVVIRVCR 12 "Cathelicidin-1 (Bactenecin-1, Bac1; Cyclic dodecapeptide; mammals, animals)" "P22226, A5PJA3, Q24JY5" Belongs to the cathelicidin family CATHL1 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Three disulfide bonds. None "Function: Potent microbicidal activity; active against S.aureus and E.coli. Tissue specificity: Large granules of neutrophils. PTM: Contains three disulfide bonds." Gram-positive bacterium: Staphylococcus aureus (MIC=1-8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=8-25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Not found 3290210 J Biol Chem. 1988 Jul 15;263(20):9573-9575. "Romeo D, Skerlavaj B, Bolognesi M, Gennaro R." Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils. DRAMP02854 GGLRSLGRKILRAWKKYGPIIVPIIRIG 28 Cathelicidin-5 (Antibacterial peptide BMAP-28; Myeloid antib "P54229, A5PJ96, B9UKL6" Belongs to the cathelicidin family CATHL5 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. PTM: Contains two disulfide bonds. (By similarity)" "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), E. coli ML35 (MIC=2 ?M), E. coli D21 (MIC=0.5 ?M), Salmonella typhimurium ATCC 14028 (MIC=1 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Staphylococcus aureus (MRSA) (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=8 ?M), Cryptococcus neoformans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461##8706679 J Biol Chem. 1996 Nov 8;271(45):28375-28381.##Eur J Biochem. 1996 Jun 15;238(3):769-776. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.##Storici P, Tossi A, Lenarcic B, Romeo D." "Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.##Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides." DRAMP02855 GRFKRFRKKFKKLFKKLSPVIPLLHLG 27 "Cathelicidin-6 (Antibacterial peptide BMAP-27, Myeloid antib" "P54228, B9UKM5" Belongs to the cathelicidin family CATHL6 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (2 helices; 19 residues) Not found 2KET resolved by NMR. "Function: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. PTM: Contains two disulfide bonds. (By similarity)" "Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1 ?g/ml), E. coli ML35 (MIC=1 ?g/ml), E. coli D21 (MIC=0.25 ?g/ml), Salmonella typhimurium ATCC 14028 (MIC=1 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?g/ml), Serratia marcescens ATCC 8100 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?g/ml), Staphylococcus aureus Cowan 1 (MIC=2 ?g/ml), Staphylococcus aureus (MRSA) (MIC=4 ?g/ml), S. epidermidis ATCC 12228 (MIC=1 ?g/ml), Bacillus megaterium Bm11 (MIC=2 ?g/ml).##Fungi: Candida albicans (MIC=8 ?g/ml), Cryptococcus neoformans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461##19136450##PubMed ID is not available J. Biol. Chem. 1996;271:28375-28381.##J. Hered. 2009;100:241-245.##To be Published "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.##Gillenwaters EN, Seabury CM, Elliott JS, Womack JE.##Yang S, Jung H, Kim J." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.##Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.##solution structure of BMAP-27. DRAMP02858 DFASCHTNGGICLPNRCPGHMIQIGICFRPRVKCCRSW 38 "Bovine Beta-defensin 1 (bBD-1; BNBD-1; BNDB-1; mammals, animals)" P46159 Belongs to the beta-defensin family DEFB1 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 but not against S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16777238 Vet Immunol Immunopathol. 2006 Sep 15;113(1-2):181-190. "Aono S, Li C, Zhang G, Kemppainen RJ, Gard J, Lu W, Hu X, Schwartz DD, Morrison EE, Dykstra C, Shi J." Molecular and functional characterization of bovine beta-defensin-1. DRAMP02859 VRNHVTCRINRGFCVPIRCPGRTRQIGTCFGPRIKCCRSW 40 "Bovine Beta-defensin 2 (bBD-2; BNBD-2; BNDB-2; mammals, animals)" P46160 Belongs to the beta-defensin family DEFB2 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 7-36; 14-29; 19-37. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02860 EGVRNHVTCRINRGFCVPIRCPGRTRQIGTCFGPRIKCCRSW 42 "Bovine Beta-defensin 3 (bBD-3; BNBD-3; BNDB-3; mammals, animals)" P46161 Belongs to the beta-defensin family DEFB3 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##9488394 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Infect Immun. 1998 Mar;66(3):1045-1056. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection." DRAMP02861 QRVRNPQSCRWNMGVCIPFLCRVGMRQIGTCFGPRVPCCRR 41 "Bovine Beta-defensin 4 (bBD-4; BNBD-4; BNDB-4; mammals, animals)" P46162 Belongs to the beta-defensin family DEFB4 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 520A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available##8454635 Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.##J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Yount N.Y, Yuan J, Diamond G, Tarver A, McGuire P.A, McCullough C, Cullor J.S, Bevins C.L, Selsted M.E.##Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Molecular cloning and expression of an antimicrobial beta-defensin from bovine neutrophils. Characterization of BNBD-4 cDNA and genomic sequences and localization of the peptide to large granules of mature neutrophils.##Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02862 QVVRNPQSCRWNMGVCIPISCPGNMRQIGTCFGPRVPCCRRW 42 "Bovine Beta-defensin 5 (bBD-5; BNBD-5; BNDB-5; mammals, animals)" "P46163, O97533" Belongs to the beta-defensin family DEFB5 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 but not against S. aureus 502A. Tissue specificity: Neutrophilic granules. Alveolar macrophages. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02863 QGVRNHVTCRIYGGFCVPIRCPGRTRQIGTCFGRPVKCCRRW 42 "Bovine Beta-defensin 6 (bBD-6; BNBD-6; BNDB-6; mammals, animals)" P46164 Belongs to the beta-defensin family DEFB6 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02865 VRNFVTCRINRGFCVPIRCPGHRRQIGTCLGPQIKCCR 38 "Bovine Beta-defensin 8 (bBD-8; BNBD-8; BNDB-8; mammals, animals)" P46166 Belongs to the beta-defensin family DEFB8 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 7-36; 14-29; 19-37. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02866 QGVRNFVTCRINRGFCVPIRCPGHRRQIGTCLAPQIKCCR 40 "Bovine Beta-defensin 9 (bBD-9; BNBD-9; BNDB-9; mammals, animals)" "P46167, O18814" Belongs to the beta-defensin family DEFB9 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-301 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##9488394 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Infect Immun. 1998 Mar;66(3):1045-1056. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection." DRAMP02867 QGVRSYLSCWGNRGICLLNRCPGRMRQIGTCLAPRVKCCR 40 "Bovine Beta-defensin 10 (bBD-10; BNBD-10; BNDB-10; mammals, animals)" "P46168, Q5W5G8" Belongs to the beta-defensin family DEFB10 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##15520886 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Mamm Genome. 2004 Oct;15(10):834-842. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Roosen S, Exner K, Paul S, Schr?der JM, Kalm E, Looft C." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue." DRAMP02868 GPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW 38 "Bovine Beta-defensin 11 (bBD-11; BNBD-11; BNDB-11; mammals, animals)" "P46169, Q5W5G7" Belongs to the beta-defensin family DEFB11 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##15520886 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Mamm Genome. 2004 Oct;15(10):834-842. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Roosen S, Exner K, Paul S, Schr?der JM, Kalm E, Looft C." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue." DRAMP02869 GPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW 38 "Bovine Beta-defensin 12 (bBD-12; BNBD-12; BNDB-12; mammals, animals)" P46170 Belongs to the beta-defensin family DEFB12 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Beta strand Not found 1BNB resolved by NMR. "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##8454636 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##J Biol Chem. 1993 Mar 25;268(9):6649-6653. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tang YQ, Selsted ME." "Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils." DRAMP02870 SGISGPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW 42 "Bovine Beta-defensin 13 (bBD-13; BNBD-13; BNDB-13; mammals, animals)" P46171 Belongs to the beta-defensin family DEFB13 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02872 GRFKRFRKKFKKLFKKLS 18 "Myeloid antimicrobial peptide BMAP-27 (1-18) (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), Escherichia coli ML35 (MIC=4 ?M), Escherichia coli D21 (MIC=4 ?M), Salmonella typhimurium ATCC 14028 (MIC=4 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Staphylococcus aureus (MRSA) (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=16 ?M), Cryptococcus neoformans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461 J Biol Chem. 1996 Nov 8;271(45):28375-28381. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. DRAMP02873 GGLRSLGRKILRAWKKYG 18 "Myeloid antimicrobial peptide BMAP-28 (1-18) (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=0.5 ?M), Escherichia coli D21 (MIC=0.5 ?M), Salmonella typhimurium ATCC14028 (MIC=2 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Staphylococcus aureus (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=16 ?M), Cryptococcus neoformans (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461 J Biol Chem. 1996 Nov 8;271(45):28375-28381. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. DRAMP02877 GGLRSLGRKILRAWKKYGPQATPATRQ 27 "mBMAP28 (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=0.5 ?M), Salmonella typhimurium ATCC 14028 (MIC=1 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.5 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=2 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=8 ?M), Cryptococcus neoformans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461 J. Biol. Chem. 1996; 271:28375-28381 "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.1996" Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. DRAMP02878 NPVSCVRNKGICVPIRCPGSMKQIGTCVGRAVKCCRKK 38 "Tracheal antimicrobial peptide (TAP; mammals, animals)" "P25068, O97532" Belongs to the beta-defensin family (LAP/TAP subfamily) Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity in vitro. In addition, the peptide is active against Candida albicans, indicating a broad spectrum of activity. Tissue specificity: Tracheal epithelium. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" "Gram-negative bacteria: Escherichia coli D31 (MIC=12-25 ?g/ml), Klebsiella pneumoniae 13883 (MIC=12-25 ?g/ml), Pseudomonas aeruginosa 27853 (MIC=25-50 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=25-50 ?g/ml).##Fungi: Candida ablicans (MIC=6-12 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2023943##8506305 Proc Natl Acad Sci U S A. 1991 May 1;88(9):3952-3956.##Proc Natl Acad Sci U S A. 1993 May 15;90(10):4596-4600. "Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL.##Diamond G, Jones DE, Bevins CL." "Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.##Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene." DRAMP02903 ILGPILGLVSNALGGLL 17 Bombin H7 No entry found Not found Not found Bombina orientalis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Bacillus megaterium Bm11 (MIC=3.3 ?M);##Gram-negative bacterium: Escherichia coli D22 (MIC=3.7 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10333736 Biopolymers. 1998;47(6):435-450. "Simmaco M, Mignogna G, Barra D." Antimicrobial peptides from amphibian skin: what do they tell us? DRAMP02910 LRRIIRKIIHIIKK 14 "Ovispirin-2 (OV-2; mammals, animals)" No entry found Not found Not found Ovis aries (Sheep) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Pseudomonas aeruginosa (MIC=0.03-16 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11557478 Antimicrob Agents Chemother. 2001 Oct;45(10):2838-2844. "Saiman L, Tabibi S, Starner TD, San Gabriel P, Winokur PL, Jia HP, McCray PB Jr, Tack BF." Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis. DRAMP02911 IRRIIRKIIHIIKK 14 "Ovispirin-3 (OV-3; mammals, animals)" No entry found Not found Not found Ovis aries (Sheep) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Pseudomonas aeruginosa (MIC=1-8 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11557478 Antimicrob Agents Chemother. 2001 Oct;45(10):2838-2844. "Saiman L, Tabibi S, Starner TD, San Gabriel P, Winokur PL, Jia HP, McCray PB Jr, Tack BF." Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis. DRAMP02922 KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPK 34 "Canine beta-defensin (dogs, mammals, animals)" No entry found Not found Not found Canis lupus familiaris (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli 25922 (MIC=20 ?g/ml), Escherichia coli 700336 (MIC=50 ?g/ml);##Gram-positive bacteria: Klebsiella pneumoniae 10031 (MIC=20 ?g/ml), Listeria monocytogenes 19115 (MIC=10 ?g/ml), Staphylococcus aureus 10832 (MIC=100 ?g/ml), N. gonorrhoeae 10150 (MIC=50 ?g/ml).##Fungi: Candida albicans 14053 (MIC=50 ?g/ml), Candida albicans 11006 (MIC=5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15845463 Infect Immun. 2005 May;73(5):2611-2620. "Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T." Molecular cloning and characterization of three beta-defensins from canine testes. DRAMP02923 KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPKFQPNMLQR 42 "cBD-1 (Canine beta-defensin 1; dogs, mammals, animals)" No entry found Not found Not found Canis Lupis (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Listeria monocytogenes(MIC=6 m?g/ml), Staphylococcus aureus (MIC=100 m?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=20-25 m?g/ml), Klebsiella pneumoniae (MIC=20 m?g/ml), Neisseria gonorrhoeae (MIC=50 m?g/ml).##Yeast: Candida albicans (MIC=5-50 m?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15845463 Infect Immun. 2005 May;73(5):2611-2620. "Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T." Molecular cloning and characterization of three beta-defensins from canine testes. DRAMP02925 RLKELITTGGQKIGEKIRRIGQRIKDFFKNLQPREEKS 38 "Cathelicidin (dogs, mammals, animals)" No entry found Not found Not found Canis lupus familiaris (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=1.25 ?M), Klebsiella pneumoniae (MIC=1.25 ?M), Salmonella serotype Typhimurium (MIC=1.25 ?M), Pseudomonas aeruginosa (MIC=1.25 ?M), Proteus mirabilis (MIC=1.25 ?M), Salmonella serotype Enteritidis (MIC=0.5 ?M), Neisseria gonorrhoeae (MIC=0.06 ?M).##Gram-positive bacteria: Listeria monocytogenes (MIC=0.5 ?M), Staphylococcus aureus (MIC=50 ?M).##Fungi: Candida albicans (MIC=12.5-50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17462733 Dev Comp Immunol. 2007;31(12):1278-1296. "Sang Y, Teresa Ortega M, Rune K, Xiau W, Zhang G, Soulages JL, Lushington GH, Fang J, Williams TD, Blecha F, Melgarejo T." "Canine cathelicidin (K9CATH): gene cloning, expression, and biochemical activity of a novel pro-myeloid antimicrobial peptide." DRAMP02931 SPRVSRRYGRPFGGRPFVGGQFGGRPGCVCIRSPCPCANYG 41 "Arasin-likeSp (crabs, Arthropods, animals)" No entry found Not found Not found Scylla paramamosain (Mud crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus haemolyticus (MIC=6.25-12.5 ?M), Aerococcus viridans (MIC=0.19-0.39 ?M), Micrococcus luteus (MIC=0.39-0.78 ?M), Bacillus subtilis (MIC=6.25-12.5 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC>50 ?M), Aeromonas hydrophila (MIC>50 ?M), V. harveyi (MIC=0.78-1.56 ?M), Vibrio anguillarum (MIC=3.125-6.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21220028 Fish Shellfish Immunol. 2011 Feb;30(2):706-712. "Imjongjirak C, Amparyup P, Tassanakajon A." "Two novel antimicrobial peptides, arasin-likeSp and GRPSp, from the mud crab Scylla paramamosain, exhibit the activity against some crustacean pathogenic bacteria." DRAMP02933 RRWCFRVCYRGFCYRKCR 18 "Polyphemusin-1 (PM1; crabs, Arthropods, animals)" P14215 Belongs to the tachyplesin/polyphemusin family Not found Limulus polyphemus (Atlantic horseshoe crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand (2 strands; 4 residues) "The solution structure of polyphemusin I is determined using (1)H-NMR spectroscopy. Polyphemusin I is found to be an amphipathic, beta-hairpin connected by a type I' beta-turn." 1RKK resolved by NMR. "Function: PM1 showes high antimicrobial activity against the Gram-negative, Gram-positive and fungal specimens tested. Tissue specificity: Hemocytes. PTM: Contains two disulfide bonds 4-17; 8-13 and C-terminal amidation." "Gram-negative bacteria: Escherichia coli UB1005 (MIC=0.5 ?g/ml), E. coli DC2 (MIC=1 ?g/ml), Salmonella typhimurium (defensin-sensitive) (MIC=0.25 ?g/ml), S. typhimurium (MIC=1 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), P. aeruginosa Z61 (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=1 ?g/ml), Enterococcus faecalis (MIC=1 ?g/ml).##Yeasy: Candida albicans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation "Disulfide bond between Cys4 and Cys17,Cys8 and Cys13." L No cytotoxicity information found Not found 2514185##15134657 J Biochem. 1989 Oct;106(4):663-668.##Biochim Biophys Acta. 2004 May 6;1698(2):239-250. "Miyata T, Tokunaga F, Yonega T, Yoshikawa K, Iwanaga S, Niwa M, Takao T, Shimonishi Y.##Powers JP, Rozek A, Hancock RE." "Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity.##Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I." DRAMP02934 RRWSFRVSYRGFSYRKSR 18 PM1-S (linear derivative of PM1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic No secondary structure (CD) "The CD spectra of PM1-S indicates that, in all environments (phosphate buffer, TFE, and liposomes), the peptide displays no observable patterns that could be related to structural features. This indicates that PM1-S is a flexible molecule with no favoured conformation." None Function: PM1-S remaines active against Gram-negative bacteria but displayed poor activity to both Gram-positive and fungal microorganisms. "Gram-negative bacteria: Escherichia coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=4 ?g/ml), Salmonella typhimurium (defensin-sensitive) (MIC=2 ?g/ml), S. typhimurium (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), P. aeruginosa Z61 (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=32 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeasy: Candida albicans (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15134657 Biochim Biophys Acta. 2004 May 6;1698(2):239-250. "Powers JP, Rozek A, Hancock RE." Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I. DRAMP02950 YVDREINLFDHYCIISRSPHISRWELKWQATVTCPGWTPVKGKVRGYSNPLSAEREATRDFVQRIVQRGLVTRDEASEWL 80 "PtALF5 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 5; crabs, Arthropods, ani" No entry found Not found Not found Portunus trituberculatus (Swimming Crab) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Contains a signal peptide and an LPS-binding Domain: (CIISRSPHISRWELKWQATVTC) and two conserved cysteine residues which can form a disulfide bridge. PtALF5 transcript in hemocytes showes a clear time-dependent response expression pattern with obvious decrease at 6 h and significant increase at 24 h. The recombinant PtALF5 has antimicrobial activity against Gram-negative bacteria Vibrio alginolyticus and Pseudomonas aeruginosa. "Gram-negative bacteria: Vibrio alginolyticus (MIC=3.89-7.78 ?M), Edwardsiella tarda (MIC=7.78-15.54 ?M), Pseudomonas aeruginosa (MIC=15.54-31.08 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 21362485##22516300 Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2012 Jul;33(1):85-91. "Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Li Q, Wang S." "Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##Molecular cloning, expression pattern and antimicrobial activity of a new isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus." DRAMP02951 MARVSLLLIVLSIALVAPSQGFLKDLLFGEAKTALLEDGTTEILDHVCNFRVMPRLRSWELYFRGDVWCPGWTVIKGESL 80 "PtALF6 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 6; crabs, Arthropods, ani" No entry found Not found Not found Portunus trituberculatus (Swimming Crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Contains a signal peptide and an LPS-binding Domain: (CNFPVMPRLRSWELYFRGDVWC) and two conserved cysteine residues which can form a disulfide bridge. "Gram-negative bacteria: Vibrio alginolyticus L59 (MIC=1.17-2.33 ?M), Pseudomonas aeruginosa P25 (MIC=9.32-18.64 ?M);##Gram-positive bacteria: Micrococcus luteus M2 (MIC=9.32-18.64 ?M), Staphylococcus aureus S7 (MIC=9.32-18.64 ?M).##Fungi: Pichia pastoris GS115 (MIC>74.57 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 21362485##23257203 Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2013 Feb;34(2):463-470. "Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Shi G." Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##A newly identified anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus with broad spectrum antimicrobial activity. DRAMP02952 MRKGVVTGLFVALVVMCLYLPQPCEAQYEALTAAILTKLSKMWHSDTLNFLGHTCHVSRTPTVKRFKLYWKGKFWCPGWA 80 "PtALF7 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 7; crabs, Arthropods, ani" No entry found Not found Not found Portunus trituberculatus (Swimming Crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Contains a signal peptide and an LPS-binding Domain: (CHVSRTPTVKRFKLYWKGKFWC) and two conserved cysteine residues which can form a disulfide bridge. "Gram-negative bacteria: Vibrio alginolyticus (MIC=0.51-1.02 ?M), Edwardsiella tarda (MIC=2.04-4.07 ?M), Pseudomonas aeruginosa (MIC=1.02-2.04 ?M);##Gram-positive bacteria: Micrococcus luteus (MIC=32.59-65.19 ?M), Staphylococcus aureus (MIC=8.15-16.30 ?M).##Fungi: Pichia pastoris (MIC>130.37 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 21362485##23261507 Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2013 Feb;34(2):652-659. "Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Shi G, Wang C." "Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##Molecular cloning, genomic structure and antimicrobial activity of PtALF7, a unique isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus." DRAMP02953 SRWPSPGRPRPFPGRPKPIFRPRPCNCYAPPCPCDRW 37 "Arasin-1 (Pro-rich, Arg-rich; crabs, Arthropods, animals)" A6XMY0 Not found Not found Hyas araneus (Great spider crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Corynebacterium glutamicum (MIC=0.8 ?M), Listonella anguillarum (MIC=6.3 ?M);##Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bond between Cys25 and Cys34,Cys27 and Cys32." L No cytotoxicity information found Not found 17658600 Dev Comp Immunol. 2008;32(3):275-285. "Stensvag K, Haug T, Sperstad S.V, Rekdal O, Indrevoll B, Styrvold O.B." "Arasin 1, a proline-arginine-rich antimicrobial peptide isolated from the spider crab, Hyas araneus." DRAMP02956 SHQDCYEALHKCMASHSKPFSCSMKFHMCLQQQ 33 Dolabellanin B2 P83376 Not found Not found Dolabella auricularia (Sea hare) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also possesses antifungal activity. PTM: Contains two disulfide bonds. Up to two of the methionines may be oxidized to methionine sulfoxides." "Gram-positive bacteria: Bacillus subtilis RIMD0225014 (MIC=2.5 ?g/ml), Staphylococcus aureus IID1677 (MRSA) (MIC=20.0 ?g/ml), Listeria monocytogenes VIU206 (MIC=40.0 ?g/ml).##Gram-negative bacteria: Haemophilus influenzae IID983 (MIC=5.0 ?g/ml), V. vulnificus RIMD2219009 (MIC=5.0 ?g/ml), Escherichia coli JM109 (MIC=20.0 ?g/ml), E. coli DH5? (MIC=40.0 ?g/ml).##Fungi: Candida albicans ATCC36232, Candida tropicalis TIMM0313, S. pombe IFO1628, Saccharomyces cerevisiae A581A." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Contains two disulfide bonds. Up to two of the methionines may be oxidized to methionine sulfoxides. L No cytotoxicity information found Not found 12590964 Dev. Comp. Immunol. 2003;27:305-311. "Iijima R, Kisugi J, Yamazaki M." A novel antimicrobial peptide from the sea hare Dolabella auricularia. DRAMP02959 RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP 39 "Antibacterial protein PR-39 (pigs, mammals, animals)" "P80054, Q9TR84" Belongs to the cathelicidin family PR39 Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Rich Not found None "Tissue specificity: Small intestine and bone marrow. PTM: Proline amide at P39." "Gram-negative bacteria: Escherichia coli K12 D21 (MIC=0.3 ?M), Escherichia coli Bd2221175 (MIC=0.3 ?M), Salmonella typhimurium LT2 (MIC=1?M), Proteus vulgaris Pvll (MIC=300 ?M), Pseudomonas aeruginosa OT97 (MIC=200 ?M), Acinetobacter calcoaceticus Acl 1 (MIC=3 ?M).##Gram-positive bacteria: Bacillus megaterium (MIC=0.3 ?M), Bacillus subtilis (MIC=15 ?M), Staphylococcus aureus (MIC=200 ?M), Streptococcus pyogenes (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1765098##7624374 Eur J Biochem. 1991 Dec 18;202(3):849-854.##Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7085-7089. "Agerberth B, Lee JY, Bergman T, Carlquist M, Boman HG, Mutt V, J?rnvall H.##Gudmundsson GH, Magnusson KP, Chowdhary BP, Johansson M, Andersson L, Boman HG." "Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides.##Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39." DRAMP02960 RIIDLLWRVRRPQKPKFVTVWVR 23 "Antibacterial peptide PMAP-23 (Myeloid antibacterial peptide 23; pigs, mammals, animals)" P49930 Belongs to the cathelicidin family PMAP23 Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Alpha helix Not found None "Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PTM: Contains two disulfide bonds (By similarity)." "Gram-negative bacteria: Escherichia coli ML35 (MIC=2 ?M), Escherichia coli ATCC 25922 (MIC=4 ?M), Salmonella typhimurium ATCC 14028 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ?M).##Gram-positive bacteria: Bacillus megaterium (MIC=2 ?M), Staphylococcus aureus ATCC 25923 (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 8132502 J Biol Chem. 1994 Mar 18;269(11):7855-7858. "Zanetti M, Storici P, Tossi A, Scocchi M, Gennaro R." Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells. DRAMP02961 GLLSRLRDFLSDRGRRLGEKIERIGQKIKDLSEFFQS 37 "Antibacterial peptide PMAP-37 (Myeloid antibacterial peptide 37; pigs, mammals, animals)" P49932 Belongs to the cathelicidin family PMAP37 Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Alpha helix Not found None "Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria with minimal inhibitory concentrations ranging over 1-4 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PTM: Contains two disulfide bonds (By similarity)." "Gram-negative bacteria: Escherichia coli ML35 (MIC=2 ?M), Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli D21 (MIC=2 ?M), Salmonella typhimurium ATCC 14028 (MIC=4 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=2 ?M).##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=4 ?M), Bacillus megaterium local isolate (IC=4 ?M), Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan 1 (MIC=64 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 7737198 Eur J Biochem. 1995 Mar 15;228(3):941-946. "Tossi A, Scocchi M, Zanetti M, Storici P, Gennaro R." "PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity." DRAMP02228 SMLSVLKNLGKVGLGFVACKINKQC 25 "RANATUERIN 1 (Frogs, amphibians, animals)" P82741 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None Function: Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. Has activity against C.albicans. Has no detectable hemolytic activity. [Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Yeast: Candida albicans (MIC=70 ?M). [Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20?g/ml against human red blood cell. Cyclic Free Cyclization (Cys19 and Cys25) Disulfide bond between Cys19 and Cys25. L No cytotoxicity information found Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02963 GRFRRLRKKTRKRLKKIGKV 20 PMAP-36(1-20) No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6 ?M), Bacillus megaterium Bm11 (MIC=3 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12 ?M), E. coli ML35 (MIC=12 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=48 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=3 ?M).##Fungi: Candida albicans c.i. (MIC>64 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02964 GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLG 34 PMAP-36(1-34) No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1 ?M), S. aureus 710A (MIC=2 ?M), S. aureus SA-62 (MRSA) (MIC=4 ?M), Bacillus megaterium Bm11 (MIC=1 ?M), S. epidermidis ATCC 12228 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), E. coli ML35 (MIC=1 ?M), E. coli D21 (MIC=1 ?M), E. coli D22 (MIC=0.5 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 ?M), S. enterica ser. Enteritidis H2 (MIC=1 ?M), P. aeruginosa ATCC 27853 (MIC=1 ?M), S. marcescens ATCC 8100 (MIC=2 ?M).##Fungi: Candida albicans c.i. (MIC=8 ?M), Cryptococcus neoformans c.i.(MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02965 GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLGC 35 PMAP-36(1-35)2 No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), S. aureus 710A (MIC=2 ?M), S. aureus SA-62 (MRSA) (MIC=4 ?M), Bacillus megaterium Bm11 (MIC=1 ?M), S. epidermidis ATCC 12228 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), E. coli ML35 (MIC=0.5 ?M), E. coli D21 (MIC=0.5 ?M), E. coli D22 (MIC=0.5 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 ?M), S. enterica ser. Enteritidis H2 (MIC=0.5 ?M), P. aeruginosa ATCC 27853 (MIC=1 ?M), S. marcescens ATCC 8100 (MIC=2 ?M).##Fungi: Candida albicans c.i. (MIC=16 ?M), Cryptococcus neoformans c.i.(MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02966 KQATVGDINTERPGILDLKGKAKWDAWNGLKGTSKEDAMKAYINKVEELKKKYGI 55 "DBI(32-86) (pigs, mammals, animals)" "P12026, A7YB23, Q9TSG2" Belongs to the ACBP family DBI Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: DBI(32-86) has antibacterial properties. Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.69 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8375398##3289918 Eur J Biochem. 1993 Sep 1;216(2):623-629.##Eur J Biochem. 1988 Jun 1;174(2):239-245. "Agerberth B, Boman A, Andersson M, J?rnvall H, Mutt V, Boman HG.##Chen ZW, Agerberth B, Gell K, Andersson M, Mutt V, Ostenson CG, Efendi? S, Barros-S?derling J, Persson B, J?rnvall H." "Isolation of three antibacterial peptides from pig intestine: gastric inhibitory polypeptide (7-42), diazepam-binding inhibitor (32-86) and a novel factor, peptide 3910.##Isolation and characterization of porcine diazepam-binding inhibitor, a polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release." DRAMP02970 RGGRLCYCRRRFCVCVGR 18 "Protegrin-1 (Protegrin 1; PG-1; pigs, mammals, animals)" P32194 Belongs to the cathelicidin family NPG1 Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Beta strand Not found 1PG1 resolved by NMR. The sequence of IB-367 is RGGLCYCRGRFCVCVGR and the peptide is active against bacteria and fungi. This peptide showed synergistic effect with LL-37 against P. aeruginosa and E. coli (Yan H & Hancock REW 2001 Antimicrob Agents Chemother 45: 1558-60). PG-1 derivatives were subjected to clinical trials. "Gram-negative bacteria: Escherichia coli (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=64 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bond between Cys6 and Cys15,Cys8 and Cys13." L "[Ref.31399625] Cytotoxicity: 661W cells(IC50=353.470.5M), HEK293T cells(IC50=276054.1M), NIH-3T3 cells(IC50=719.259.5M), SH-SY5Y cells(IC50=590.458.2M), PMN cells(IC50=948.964.1M), and 3D4/2 cells(IC50=391.171.3M)" Cell membrane 8647100 Chem Pharm Bull (Tokyo). 1995 May;43(5):853-858. "Tamamura H, Murakami T, Horiuchi S, Sugihara K, Otaka A, Takada W, Ibuka T, Waki M, Yamamoto N, Fujii N." Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity. DRAMP02975 VRRFPWWWPFLRR 13 "Tritrpticin (Trp-rich; pigs, mammals, animals)" No entry found Belongs to the cathelicidin family Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix (1 helices; 3 residues) Not found 1D6X resolved by NMR. Function: Tritrpticin has strong antimicrobial activity with a wide spectrum. "Gram-negative bacteria: Escherichia coli (5 mm), Pseudomonas aeruginosa (3 mm), Klebsiella pneumonia (7 mm), Proteus mirabilis (1 mm);##Gram-positive bacteria: Staphylococcus epidermidis (5 mm), Streptococcus group D (4 mm). [inhibit zones in mm]##Fungi: Aspergillus fumigatus (MIC=250 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8706838##10606506 FEBS Lett. 1996 Jul 15;390(1):95-98.##Biochemistry. 1999 Dec 21;38(51):16749-55. "Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K.Schibli DJ, Hwang PM, Vogel HJ.##Schibli DJ, Hwang PM, Vogel HJ." Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides.##Structure of the antimicrobial peptide tritrpticin bound to micelles: a distinct membrane-bound peptide fold. DRAMP03028 IDWKKLLDAAKQIL 14 Polybia-MP1 No entry found Not found Not found Polybia paulista "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. "[Ref.29075946] Gram-positive bacterium: Bacillus subtilis (MIC=12.5M), Staphylococcus aureus (MIC=18.8M);##Gram-negative bacterium:Escherichia coli (MIC=75M), Shigella dysenteriae (MIC=75M), Klebsiella pneumoniae (MIC=37.5M)" "[Ref.29075946] <1% hemolysis at 12.5M, 3.2% hemolysis at 25M against human red blood cells." stapled peptide Free Amidation tethers Lys6 and Arg10 L No cytotoxicity information found Not found 29075946 Arch Pharm Res. 2017 Dec;40(12):1414-1419. "Luong HX, Kim DH, Lee BJ, Kim YW" Antimicrobial activity and stability of stapled helices of polybia-MP1 DRAMP03721 ILGKIWEGIKSLF 13 IsCT1 Q8MMJ7 Belongs to the scorpion NDBP 5 family Not found Opisthacanthus madagascariensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix "Residue 6 is important for antibacterial activity, and hemolysis activity" None Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. "[Ref.28657596] Gram-positive bacterium:Staphylococcus aureus (MIC=50g/mL);##Gram-negative bacterium: S. typhimurium (MIC=100g/mL), Escherichia coli (MIC=50g/mL)" "[Ref.28657596] 2% hemolysis at 10 g/ml, 96% hemolysis at 50 g/ml against human red blood cells." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 28657596 Antibiotics (Basel). 2017 Jun 28;6(3). pii: E13. "de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM." Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides DRAMP01377 FMPILSCSRFKRC 13 "Odorranain-G1 (OdG1; Frogs, amphibians, animals)" "A6MBL7, A6MBL8" Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-G1 adopts 44.1% -sheet structure in water solution. None Function: Odorranain-G1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 g/ml), Bacillus subtilis (MIC=37.5 g/ml).##Yeast: Candida albicans (MIC=1.10 g/ml)." [Ref:17272268] It has no hemolytic activity against rabbit red blood cells Cyclic Free Cyclization (Cys7 and Cys13) Disulfide bond between Cys7 and Cys13. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02995 QERGSIVIQGTKEGKSRPSLDIDYKQRVYDKNGMTGDAYGGLNIRPGQPSRQHAGFEFGKEYKNGFIKGQSEVQRGPGGRLSPYFGINGGFRF 93 "Hymenoptaecin (Insects, animals)" Q10416 Not found Not found Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli K514 (MIC=0.5-1 ?M), E. coli K514 anaerobic, E. coli NCTC9001 (MIC=1-5 ?M), Xanthomonas campestris (MIC=0.5-1 ?M), Pseudomonas solanacearum (MIC>10 ?M), Erwinia carotovora ssp.(MIC=1-5 ?M);##Gram-positive bacteria: Micrococcus lysodeikticus (MIC=1-5 ?M), Bacillus megaterium (MIC=0.5-1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8463238 J Biol Chem. 1993 Apr 5;268(10):7044-7054. "Casteels P, Ampe C, Jacobs F, Tempst P." "Functional and chemical characterization of Hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera)." DRAMP02996 GNNRPIYIPQPRPPHPRL 18 "Apidaecin-2 (Apidaecin II; Insects, animals)" "Q06601, P11525, P11526, P11527" Belongs to the apidaecin family APID14 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 ?g/ml), Erwinia salicis (MIC=0.02 ?g/ml), Escherichia coli (MIC=0.2 ?g/ml), Pseudomonas syringae (MIC=0.1 ?g/ml), Rhizobium meliloti (MIC=0.02 ?g/ml), Salmonella Newport (MIC=0.2 ?g/ml), Salmonella typhimurium (MIC=0.1 ?g/ml);##Gram-positive bacteria: Shigella flexneri (MIC=0.1 ?g/ml), Corynebacterium insidiosum (MIC=100 ?g/ml), Bacillus megaterium (MIC=100 ?g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2676519 EMBO J. 1989 Aug;8(8):2387-2391. "Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P." Apidaecins: antibacterial peptides from honeybees. DRAMP02441 VXLFPVXLFP 10 Gramicidin S No entry found Not found Not found Bacillus brevis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Beta sheet and beta-turn The peptide have the C2-symmetrical sequence [cyclo-(Val-Orn-Leu-D-Phe-Pro)2]. The two sequences Val-Orn-Leu form an antiparallel None Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. "[Ref.29499484] Gram-positive bacterium:Staphylococcus aureus subsp.aureus CIP 4.83 ATCC 6538 (MIC=3.125g/mL),Bacillus subtilis subsp. subtilis CIP 52.65 (MIC=3.125g/ml),Enterococcus faecalis CIP 103015 (MIC=3.125g/ml),Enterococcus faecalis CIP 103214 (MIC=3.125g/ml),Bacillus cereus CIP 66.24 (MIC=6.25g/ml),Streptococcus salivarius CIP 102503 (MIC=3.125g/ml),Enterococcus faecium CIP 103014 (MIC=3.125g/ml);##Gram-negative bacterium:Escherichia coli CIP 53.126 ATCC 8739 (MIC=12.5g/ml),Pseudomonas aeruginosa CIP 82.118 ATCC 9027 (MIC>=100g/ml)" "[Ref.29499484] It has 74% hemolysis at 50g/ml, 83% hemolysis at 100g/ml against human red blood cells." Cyclic No specific N-terminal No specific C-terminal The 'O' in sequence is Ornithine Mixed(D-Phe) No cytotoxicity information found Not found 29499484 Eur J Med Chem. 2018 Apr 10;149:122-128. "Wan Y, Stanovych A, Gori D, Zirah S, Kouklovsky C, Alezra V." ",-diamino acids as building blocks for new analogues of Gramicidin S: Synthesis and biological activity" DRAMP02998 GNNRPVYIPQPRPPHPRI 18 "Apidaecin-1A (Apidaecin IA; Insects, animals)" "Q06602, P11525, P11526" Belongs to the apidaecin family APID73 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 ?g/ml), Erwinia salicis (MIC=0.02 ?g/ml), Escherichia coli (MIC=0.1 ?g/ml), Pseudomonas syringae (MIC=0.2 ?g/ml), Rhizobium meliloti (MIC=0.1 ?g/ml), Salmonella Newport (MIC=0.2 ?g/ml), Salmonella typhimurium (MIC=0.1 ?g/ml), Shigella flexneri (MIC=0.1 ?g/ml);##Gram-positive bacteria: Corynebacterium insidiosum (MIC=50 ?g/ml), Bacillus megaterium (MIC=150 ?g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2676519 EMBO J. 1989 Aug;8(8):2387-2391. "Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P." Apidaecins: antibacterial peptides from honeybees. DRAMP02999 PFKISIHL 8 "Jellein-1 (Jelleine-I; chain of Major royal jelly protein 1; Insects, animals)" "O18330, Q548D6" Belongs to the major royal jelly protein family MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-1 has antibacterial and antifungal activity. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. Developmental stage: Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee. Miscellaneous: Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival. Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days. PTM: Histidine amide at H7." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=10 ?g/ml), S. saprophyticus (MIC=15 ?g/ml), Bacillus subtilis CCT 2471 (MIC=10 ?g/ml).##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=2.5 ?g/ml), Enterobacter cloacae ACCT 23355 (MIC=10 ?g/ml), Klebsiella pneumoniae ACCT 13883 (MIC=10 ?g/ml), Pseudomonas aeruginosa ACCT 27853 (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=2.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237##9395329##21516106 Peptides. 2004 Jun;25(6):919-928.##Eur J Biochem. 1997 Nov 1;249(3):797-802.##Nature. 2011 May 26;473(7348):478-483. "Fontana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS.##Ohashi K, Natori S, Kubo T.##Kamakura M." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).##Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.##Royalactin induces queen differentiation in honeybees. DRAMP03000 TPFKISIHL 9 "Jellein-2 (Jelleine-II; chain of Major royal jelly protein 1; Insects, animals)" "O18330, Q548D6" Belongs to the major royal jelly protein family MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-2 has antibacterial and antifungal activity. Jellein-2 is probably processed to yield jellein-1 and jellein-4. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. Developmental stage: Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee. Miscellaneous: Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival. Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days. PTM: Leucine amide at L9." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=15 ?g/ml), S. saprophyticus (MIC=10 ?g/ml), Bacillus subtilis CCT 2471 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=15 ?g/ml), Enterobacter cloacae ACCT 23355 (MIC=15 ?g/ml), Klebsiella pneumoniae ACCT 13883 (MIC=15 ?g/ml), Pseudomonas aeruginosa ACCT 27853 (MIC=15 ?g/ml).##Yeast: Candida albicans (MIC=2.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237##9395329##21516106 Peptides. 2004 Jun;25(6):919-928.##Eur J Biochem. 1997 Nov 1;249(3):797-802.##Nature. 2011 May 26;473(7348):478-483. "Fontana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS.##Ohashi K, Natori S, Kubo T.##Kamakura M." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).##Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.##Royalactin induces queen differentiation in honeybees. DRAMP03001 EPFKISIHL 9 "Jellein-3 (Jelleine-III; Insects, animals)" P84759 Not found MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-3 has antibacterial and antifungal activity. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. PTM: Leucine amide at L9." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=30 ?g/ml), S. saprophyticus (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT1371 (MIC=15 ?g/ml), Enterobacter cloacae ATCC 23355, Klebsiella pneumoniae ATCC 13883, Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?g/ml).##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237 Peptides. 2004 Jun;25(6):919-928. "ntana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera). DRAMP03057 GSKKPVPIIYCNRRTGKCQRM 21 "Thanatin(insects, arthropods, invertebrates, animals)" P55788 Not found Not found Podisus maculiventris "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand "Contain C-terminally a loop of 6 residues, delineated by an intramolecular disulfide bridge. This loop carries a strong positive charge in both molecules and contains a central threonine residue, which separates two subgroups of electropositivity." 8TFV Function: Insect defense peptide with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and fungi. No activity against S.aureus. Stops respiration in bacteria but does not permeabilize their inner membranes. Has no detectable hemolytic activity. "[Ref.8577744] Gram-positive bacteria: Aerococcus viridans (MIC=0.6-1.2 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Bacillus subtilis (MIC=2.5-5 ?M), Pediococcus acidilactici (MIC=20-40 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.3-0.6 ?M), Escherichia coli D31 (MIC=0.3-0.6 ?M), Escherichia coli 1106 (MIC=0.6-1.2 ?M), Salmonella typhimurium (MIC=0.6-1.2 ?M), Klebsiella pneumoniae (MIC=0.6-1.2 ?M), Enterobacter cloacae (MIC=1.2-2.5 ?M), Erwinia carotovora (MIC=10-20 ?M), Pseudomonas aeruginosa (MIC=20-40 ?M);##Fungi: Neurospora crassa (MIC=0.6-1.2 ?M), Botrytis cinerea (MIC=1.2-2.5 ?M), Nectria haematococca (MIC=1.2-2.5 ?M), Trichoderma viride (MIC=1.2-2.5 ?M), Alternaria brassicicola (MIC=2.5-5 ?M), Fusarium culmorum (MIC=2.5-5 ?M), Ascochyta pisi (MIC=5-10?M), Fusarium oxysporum (MIC=10-20 ?M)." [Ref.8577744] It exhibits no hemolytic activity at 40 ?M against porcine erythrocytes. Cyclic Free Free Disulfide bond between Cys11 and Cys18. L No cytotoxicity information found Not found 8577744##9760181 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.##Eur J Biochem. 1998 Sep 1;256(2):404-410. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA.##Mandard N, Sodano P, Labbe H, Bonmatin JM, Bulet P, Hetru C, Ptak M, Vovelle F." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.##Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data." DRAMP03003 GFLSILKKVLPKVMAHMK 18 "Melectin (MEP; Insects, animals)" P86170 Not found Not found Melecta albifrons (Cuckoo bee) (Melecta punctata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacteria as well as Gram-negative bacteria. Stimulates degranulation from rat peritoneal mast cells with an EC50 of 19.4 ?M. Has weak hemolytic activity towards rat erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." "[Ref.18942691]Gram-positive bacteria: Bacillus subtilis (MIC=0.8 ?M), Staphylococcus aureus (MIC=6.8 ?M);##Gram-negative bacteria: Escherichia coli (MIC=2.0 ?M), Pseudomonas aeruginosa (MIC=18.5 ?M)." [Ref.18942691]LC50>100 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18942691 Chembiochem. 2008 Nov 24;9(17):2815-2821. "Cerovsk? V, Hovorka O, Cvacka J, Voburka Z, Bednrov L, Borovickov L, Slaninov J, Fuck V." Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons. DRAMP03007 GFLSALKKYLPIVLKHV 17 "Osmin (Insects, animals)" P0CD70 Not found Not found Osmia rufa (Red mason bee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (CD) "In absence of TFE, the spectrum shows a random coil type structure. When increasing the concentration of TFE from 0 to 20%, a transition into an -helix structure is observed." None "Function: Synthetic peptide exhibits hemolytic activity to human erythrocytes and inhibits bacterial and fungal growth at micromolar concentrations. A synthetic peptide with a free C-terminus shows weaker hemolytic (5.0 HU/mg), antibacterial and antifungal activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." [Ref.19109988]Gram-positive bacterium: Micrococcus luteus (MIC=1.56-0.78 ?M);##Gram-negative bacterium: Escherichia coli SBS363 (MIC=3.125-1.56 ?M);##fungi: Fusarium oxysporum (MIC=0.78-0.39 ?M). [Ref.19109988]5.0 HU/mg hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19109988 Toxicon. 2010 Jan;55(1):20-27. "?cklin R, Favreau P, Thai R, Pflugfelder J, Bulet P, Mebs D." Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (hymenoptera: megachilidae). DRAMP03019 INWLKLGKKILGAL 14 Mastoparan PDD-B No entry found Belongs to the mastoparan family Not found Polistes dorsalis dorsolis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. PDD-B has hemolytic activity. [Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=70 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15.5 ?M). [Ref.18375018]IC50=45 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18375018 Peptides. 2008 Jun;29(6):992-1003. "Cerovsk? V, Slaninov J, Fuck V, Hulacov H, Borovickov L, Jezek R, Bednrov L." New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs. DRAMP03020 INWKKIFEKVKNLV 14 Mastoparan PDD-A No entry found Belongs to the mastoparan family Not found Polistes dorsalis dorsolis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. PDD-A shows little hemolytic activity. [Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=11.8 ?M);##Gram-negative bacterium: Escherichia coli (MIC=7.5 ?M). [Ref.18375018]IC50>100 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18375018 Peptides. 2008 Jun;29(6):992-1003. "Cerovsk? V, Slaninov J, Fuck V, Hulacov H, Borovickov L, Jezek R, Bednrov L." New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs. DRAMP03021 INWKKIASIGKEVLKAL 17 Mastoparan PMM No entry found Belongs to the mastoparan family Not found Polistes major major "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. Shows hemolytic activity. [Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=7.3 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25.8 ?M). [Ref.18375018]IC50=80 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18375018 Peptides. 2008 Jun;29(6):992-1003. "Cerovsk? V, Slaninov J, Fuck V, Hulacov H, Borovickov L, Jezek R, Bednrov L." New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs. DRAMP03022 INWLKLGKKMMSAL 14 Mastoparan MP No entry found Belongs to the mastoparan family Not found Mischocyttarus phthisicus "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. Has hemolytic activity. [Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli (MIC=65 ?M). [Ref.18375018]IC50=100 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18375018 Peptides. 2008 Jun;29(6):992-1003. "Cerovsk? V, Slaninov J, Fuck V, Hulacov H, Borovickov L, Jezek R, Bednrov L." New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs. DRAMP01739 LLPIVGNLLKSLL 13 "Temporin-B (Frogs, amphibians, animals)" P79874 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found 6GIL resolved by NMR. "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has hemolytic activity. PTM: Leucine amide at position 13. Tissue specificity: Expressed by the skin glands." "[Ref.9022710] Gram-positive bacteria: Bacillus megaterium BM11 (LC=2.8 ?M), Staphylococcus aureus Cowanl (LC=6.0 ?M), Streptococcus pyogenes betahemolytic group A (LC=7.0 ?M);##Gram-negative bacteria: Escherichia coli D21(LC=21.0 ?M), Escherichia coli D21e7 (LC=13.2 ?M), Escherichia coli D21f1 (LC=10.0 ?M), Escherichia coli D21f2 (LC=3.3 ?M), Escherichia coli D22 (LC=11.2 ?M),Yersinia pseudotuberculosis (LC=7.0 ?M), Pseudomonas aeruginosa ATCC15692 (LC>360 ?M);##Yeast: Candida albicans (LC=4.0 ?M).(LC: Lethal concentration).##[Ref.28443279] Gram-positive bacterium: S.aureus ATCC 33591 (MIC=12M), Staphylococcus epidermidis (MIC=6M);##Gram-negative bacterium: Klebsiella pneumoniae ATCC BAA-1706 (MIC=48M), Pseudomonas aeruginosa ATCC 27853 (MIC=48M)" [Ref.9022710] LC>120 ?M against Human red blood cells. (LC: Lethal concentration)##[Ref.28443279] 1% hemolysis at 96M against human red blood cells. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9022710##28443279 Eur J Biochem. 1996 Dec 15;242(3):788-792.##Front Chem. 2017 Apr 11;5:24. "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.##Grassi L, Maisetta G, Maccari G, Esin S, Batoni G." "Temporins, antimicrobial peptides from the European red frog Rana temporaria.##Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide" DRAMP03033 INWKGIAAMAKKLL 14 "Mastoparan-like peptide 12a (Insects, animals)" P0C1M4 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide. Has little hemolytic activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " [Ref.17046111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 ?g/ml);##Fungi: Candida albicans ATCC 2002 (MIC=3.7 ?g/ml). [Ref.16330062]Little hemolytic activity at 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062##17046111 Toxicon. 2006 Feb;47(2):249-253.##Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.##Xu X, Yang H, Yu H, Li J, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom.##The mastoparanogen from wasp. DRAMP03034 INWKGIAAMKKLL 13 "Mastoparan-like peptide 12b (Insects, animals)" P0C1M5 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide. Has little hemolytic activity. Shows antimicrobial activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L13)." [Ref.16330062]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 ?g/ml);##Fungi: Candida albicans ATCC 2002 (MIC=7.5 ?g/ml). [Ref.16330062]Little hemolytic activity at 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. Epub 2005 Dec 5. Peptides. 2006 Dec;27(12):3053-7. Epub 2006 Oct 13. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.Xu X, Yang H, Yu H, Li J, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venomThe mastoparanogen from wasp. DRAMP03035 INLKAIAALAKKLLG 15 "Mastoparan-like peptide 12c (Insects, animals)" A0SPI0 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows mast cell degranulation and antimicrobial activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.0 ?g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=12.0 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17046111 Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Yang H, Yu H, Li J, Lai R." The mastoparanogen from wasp. DRAMP03036 INLKAIAAMAKKLL 14 "Mastoparan-like peptide 12d (Insects, animals)" P0C5G7 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows mast cell degranulation and antimicrobial activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=1.5 ?g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=12.0 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17046111 Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Yang H, Yu H, Li J, Lai R." The mastoparanogen from wasp. DRAMP03037 LNLKGIFKKVASLLT 15 "Eumenitin (Er-12; Insects, animals)" P0C931 Not found Not found Eumenes rubronotatus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Cationic linear alpha-helical antimicrobial peptide that binds preferentially to charged lipid membranes as compared with zwitterionic ones. It exhibits inhibitory activity against both Gram-positive and Gram-negative bacteria, and moderately stimulates degranulation from the rat peritoneal mast cells. Does not show hemolytic activity. May play a role in preventing infection by microorganisms during prey consumption by their larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16762455]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC>60 ?M), Staphylococcus aureus ATCC 25923 (MIC=6 ?M), Staphylococcus saprophytius (CS) (MIC=6 ?M), Staphylococcus epidermius (CS) (MIC>60 ?M), Bacillus subtilis CCT 2471 (MIC=60 ?M), Bacillus thuringiensis (WT) (MIC>60 ?M);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=6 ?M), Escherichia coli ATCC 25922 (MIC=6 ?M), Escherichia cloacae ATCC 23355 (MIC>60 ?M), Proteus mirabilis (CS) (MIC>60 ?M), Pseudomonas aeruginosa ATCC 15442 (MIC=30 ?M)." [Ref.16762455]Non-hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 16762455##18206199 Peptides. 2006 Nov;27(11):2624-2631.##Toxicon. 2008 Apr;51(5):736-745. "Konno K, Hisada M, Naoki H, Itagaki Y, Fontana R, Rangel M, Oliveira JS, Cabrera MP, Neto JR, Hide I, Nakata Y, Yasuhara T, Nakajima T.##Arcisio-Miranda M, dos Santos Cabrera MP, Konno K, Rangel M, Procopio J." "Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus.##Effects of the cationic antimicrobial peptide eumenitin from the venom of solitary wasp Eumenes rubronotatus in planar lipid bilayers: surface charge and pore formation activity." DRAMP03038 LNLKGLIKKVASLLN 15 "Eumenitin-R (Insects, animals)" P0CJ36 Not found Not found Eumenes rubrofemoratus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=60 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=15 ?M), Streptococcus pyogenes (clinical sample) (MIC=15 ?M), Bacillus subtilis ATCC 6633 (MIC=7.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 ?M);##Fungi: Candida albicans ATCC 90112 (MIC<7.5 ?M)." [Ref.21549739]EC50=530.3 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03039 LNLKGLFKKVASLLT 15 "Eumenitin-F (Insects, animals)" P0CJ37 Not found Not found Eumenes fraterculus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>60 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=30 ?M), Streptococcus pyogenes (clinical sample) (MIC=30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC>60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=353.4 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03040 FDVMGIIKKIAGAL 14 "Eumenine mastoparan-EF (EMP-EF; Insects, animals)" P0CJ39 Not found Not found Eumenes fraterculus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=30 ?M), Streptococcus pyogenes (clinical sample) (MIC>30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=181.1 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03041 FDIMGLIKKVAGAL 14 "Eumenine mastoparan-ER (EMP-ER; Insects, animals)" P0CJ38 Not found Not found Eumenes rubrofemoratus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC>30 ?M), Streptococcus pyogenes (clinical sample) (MIC>30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=200 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03042 INLLKIAKGIIKSL 14 "Eumenine mastoparan-AF (EMP-AF; Af-113; Insects, animals)" P0C022 Not found Not found Anterhynchium flavomarginatum micado (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None "Function: Mast cell degranulating peptide. Also permeates anionic liposomes. Has hemolytic activity. Has an amphiphilic alpha-helix conformation. Shows broad-spectrum antimicrobial activity. Blocks the lobster neuromuscular transmission. Induces the depolarization of the muscle membrane. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.15317499]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC=5 ?g/ml), S. saprophyticus CS (MIC=5 ?g/ml), S. epidermidis CS (MIC=5 ?g/ml), Bacillus subtilis CCT 2471 (MIC=40 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=20 ?g/ml), Escherichia coli ATCC 25922 (MIC=50 ?g/ml), Pseudomonas aeruginosa ATCC 15442 (MIC=20 ?g/ml)." [Ref.10775751]100% hemolytic activity against human erythrocytes at 10^-4 M Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 15317499##11006592##10775751 J Pept Res. 2004 Sep;64(3):95-103.##Rapid Commun Mass Spectrom. 2000;14(19):1828-1834.##Toxicon. 2000 Nov;38(11):1505-1015. "dos Santos Cabrera M.P, de Souza B.M, Fontana R, Konno K, Palma M.S, de Azevedo W.F. Jr, Neto J.R.##Hisada M, Konno K, Itagaki Y, Naoki H, Nakajima T.##Konno K, Hisada M, Naoki H, Itagaki Y, Kawai N, Miwa A, Yasuhara T, Morimoto Y, Nakata Y." "Conformation and lytic activity of eumenine mastoparan: a new antimicrobial peptide from wasp venom.##Advantages of using nested collision induced dissociation/post-source decay with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: sequencing of novel peptides from wasp venom.##Structure and biological activities of eumenine mastoparan-AF (EMP-AF), a new mast cell degranulating peptide in the venom of the solitary wasp (Anterhynchium flavomarginatum micado)." DRAMP03043 INWLKLGKAIIDAL 14 "Agelaia-mastoparan (Agelaia-MP; Insects, animals)" P69436 Not found Not found Agelaia pallipes pallipes (Neotropical social wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Hemolytic mast cell degranulator, presenting no antimicrobial action and no chemotaxis for polymorphonucleated leukocytes (PMNL). Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.15225564]Gram-negative bacteria: Escherichia coli (MIC=382 ?g/ml), Pseudomonas aeruginosa (MIC=257 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=237 ?g/ml), Staphylococcus aureus (MIC=191 ?g/ml)." [Ref.15225564]70% hemolytic activity at 156 ng/ml against rat erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15225564##15052574 Toxicon. 2004 Jul;44(1):67-74.##Rapid Commun Mass Spectrom. 2004;18(6):636-642. "Mendes MA, de Souza BM, Marques MR, Palma MS.##Mendes MA, Monson de Souza B, Delazari dos Santos L, Palma MS." Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes.##Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. DRAMP03044 ILGTILGLLKGL 12 "Protonectin (Agelaia-chemotactic peptide, Agelaia-CP; Insects, animals)" P69437 Not found Not found Agelaia pallipes pallipes (Neotropical social wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Mast cell degranulator that induces a potent chemotaxis in polymorphonucleated leukocyte (PMNL) cells. Shows potent antimicrobial action against both Gram-positive and Gram-negative bacteria. Shows no hemolytic activity. "[Ref.15225564]Gram-negative bacteria: Escherichia coli (MIC=25 ?g/ml), Pseudomonas aeruginosa (MIC=1.7 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=3.1 ?g/ml), Staphylococcus aureus (MIC=12.5 ?g/ml)." [Ref.15052574]Non-hemolytic activity against rat red blood cell Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15225564##15052574 Toxicon. 2004 Jul;44(1):67-74.##Rapid Commun Mass Spectrom. 2004;18(6):636-642. "Mendes MA, de Souza BM, Marques MR, Palma MS.##Mendes MA, Monson de Souza B, Delazari dos Santos L, Palma MS." Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes.##Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. DRAMP03045 VTCELLMFGGVVGDSACAANCLSMGKAGGSCNGGLCDCRKTTFKELWDKRFG 52 "Defensin-NV (Insects, animals)" No entry found Not found Not found Nasonia vitripennis (Ectoparasitic wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Bridge Not found None "Function: Defensin-NV had little hemolytic activity to rabbit red blood cells and has antimicrobial activity against Gram-positive, Gram-negative bacteria, and Fungi." "[Ref.20362606]Gram-positive bacteria: Staphylococcus aureus (MIC=0.93 ?M), Bacillus cereus (MIC=0.93 ?M), B. dysenteriae (MIC=0.46 ?M);##Gram-negative bacteria: Escherichia coli (MIC=1.86 ?M), Pseudomonas aeruginosa (MIC=9.3 ?M).##Yeast: Candida albicans (MIC=1.86 ?M)." [Ref.20362606]5% hemolytic activity at 200 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20362606 Toxicon. 2010 Aug 1;56(1):101-106. "Ye J, Zhao H, Wang H, Bian J, Zheng R." A defensin antimicrobial peptide from the venoms of Nasonia vitripennis. DRAMP03047 EPILGIITSLLKSL 14 "Venom peptide 2-long (OdVP2L; analog of OdVP2; Insects, animals)" "P86147, C7DT08" Belongs to the MCD family (Protonectin subfamily) VP2 Orancistrocerus drewseni (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations. Tissue specificity: Expressed by the venom gland." "[Swiss_Prot Entry P86147]Fungi: Botrytis cinerea (MIC=0.5 ?g/ml), Candida albicans (MIC=100 ?g/ml);##Gram-positive bacterium: S. aureus (MIC=25 ?g/ml);##Gram-negative bacterium: Escherichia coli." [Swiss_Prot Entry P86147]has potent hemolytic activity against ovine erythrocytes at micromolar concentrations Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19857508##18695936 Toxicon. 2010 Apr 1;55(4):711-718.##Amino Acids. 2009 Jul;37(2):389-394. "Baek JH, Lee SH.##Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T." "Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).##Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni." DRAMP03050 INWKKIAEVGGKILSSL 17 "Dominulin-A (Insects, animals)" P0C1M6 Belongs to the MCD family (Mastoparan subfamily) Not found Polistes dominulus (European paper wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Shows antimicrobial activity. Gram-positive bacterium: Bacillus subtilis ATCC 6633 (MIC=2 ?g/ml);##Gram-negative bacterium: Escherichia coli JM109 (MIC=8 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16446098 J Am Soc Mass Spectrom. 2006 Mar;17(3):376-383. "Turillazzi S, Mastrobuoni G, Dani FR, Moneti G, Pieraccini G, la Marca G, Bartolucci G, Perito B, Lambardi D, Cavallini V, Dapporto L." "Dominulin A and B: two new antibacterial peptides identified on the cuticle and in the venom of the social paper wasp Polistes dominulus using MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap." DRAMP03051 INWKKIAEIGKQVLSAL 17 "Dominulin-B (Insects, animals)" P0C1M7 Belongs to the MCD family (Mastoparan subfamily) Not found Polistes dominulus (European paper wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Shows antimicrobial activity. Gram-positive bacterium: Bacillus subtilis ATCC 6633 (MIC=2 ?g/ml);##Gram-negative bacterium: Escherichia coli JM109 (MIC=8 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16446098 J Am Soc Mass Spectrom. 2006 Mar;17(3):376-383. "Turillazzi S, Mastrobuoni G, Dani FR, Moneti G, Pieraccini G, la Marca G, Bartolucci G, Perito B, Lambardi D, Cavallini V, Dapporto L." "Dominulin A and B: two new antibacterial peptides identified on the cuticle and in the venom of the social paper wasp Polistes dominulus using MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap." DRAMP03055 YVPPVQKPHPNGPKFPTFP 19 "PP30 (Pro-rich; abaecin-like; Insects, animals)" No entry found Not found Not found Pteromalus puparum (wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=23.32.1 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=16.72.1 ?M), Staphylococcus aureus (MIC=133.311.6 ?M), Sarcina lutea (MIC=13.31.2 ?M), Bacillus pumilu (MIC=13.32.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20466006 J Invertebr Pathol. 2010 Sep;105(1):24-29. "Shen X, Ye G, Cheng X, Yu C, Altosaar I, Hu C." Characterization of an abaecin-like antimicrobial peptide identified from a Pteromaluspuparum cDNA clone. DRAMP03056 SLLSLIRKLIT 11 "Decoralin (Insects, animals)" P85870 Not found Not found Oreumenes decoratus (Potter wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide. At high concentrations exhibits activity in stimulating degranulation from rat peritoneal mast cells. Inhibits the growth of L.major promastigotes in vitro with an IC50 of 72 ?M. Has hemolytic activity towards human and mouse erythrocytes. Tissue specificity: Expressed by the venom gland." "[Ref.17981364]Gram-positive bacteria: Staphylococcus aureus CCT 6538 (MIC=40 ?M), S. saprophyticus (MIC=40 ?M), Bacillus subtilis CCT 2471 (MIC=40 ?M), B. thuringiensis (MIC=40 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=80 ?M), Escherichia coli CCT 1371 (MIC=160 ?M), Klebsiella pneumoniae ATCC 13883 (MIC=80 ?M), A. faecalis ATCC 8750 (MIC=40 ?M);##Fungi: Candida albicans (MIC=40 ?M), L. major promastigotes (IC50=72 ?M)." [Ref.17981364]EC50=1 mM against mouse erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 17981364 Peptides. 2007 Dec;28(12):2320-2327. "Konno K, Rangel M, Oliveira JS, Dos Santos Cabrera MP, Fontana R, Hirata IY, Hide I, Nakata Y, Mori K, Kawano M, Fuchino H, Sekita S, Neto JR." "Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus." DRAMP03819 RRWWRF 6 Cyclic hexapeptide CYC-(RRWWRF) No entry found Not found Not found Synthetic construct "Antimicrobial, Anti-Gram+, Anti-Gram-" Synthetic Non helix or strand structure (Turn) Not found "1QVK,1QVL" Function: Antibacterial activity against Escherichia coli and Bacillus subtilis. Has hemolytic activity. [Ref.16075425] Gram-negative bacterium: Escherichia coli(MIC=6.3 M);##Gram-positive bacterium: Bacillus subtilis(MIC=3.1 M) [Ref.16075425] It has 24% hemolysis at 100 M against erythrocytes. Cyclic No specific N-terminal No specific C-terminal None L No cytotoxicity information found Not found 16075425##7883644 Chembiochem. 2005 Sep;6(9):1654-1662.##J Appl Bacteriol. 1995 Jan;78(1):39-46. "Appelt C, Wessolowski A, S?derh??ll JA, Dathe M, Schmieder P.##Blondelle SE, Takahashi E, Dinh KT, Houghten RA." "Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles.##The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries." DRAMP03820 RRYYRF 6 Cyclic hexapeptide RRYYRF No entry found Not found Not found Synthetic construct "Antimicrobial, Anti-Gram+, Anti-Gram-" Synthetic Non helix or strand structure (Turn) Not found 1SKI Function: Antibacterial activity against Escherichia coli and Bacillus subtilis. Has hemolytic activity. [Ref.16075425] Gram-negative bacterium: Escherichia coli(MIC>100 M);##Gram-positive bacterium: Bacillus subtilis(MIC>100 M) [Ref.16075425] It has 1% hemolysis at 100 M against erythrocytes. Cyclic No specific N-terminal No specific C-terminal None L No cytotoxicity information found Not found 16075425 Chembiochem. 2005 Sep;6(9):1654-1662. "Appelt C, Wessolowski A, S?derh??ll JA, Dathe M, Schmieder P." "Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles." DRAMP03821 KKWWKF 6 Cyclic hexapeptide KKWWKF No entry found Not found Not found Synthetic construct "Antimicrobial, Anti-Gram+, Anti-Gram-" Synthetic Non helix or strand structure (Turn) Not found 1SKK Function: Antibacterial activity against Escherichia coli and Bacillus subtilis. Has hemolytic activity. [Ref.16075425] Gram-negative bacterium: Escherichia coli(MIC=25 M);##Gram-positive bacterium: Bacillus subtilis(MIC=25 M) [Ref.16075425] It has 10% hemolysis at 100 M against erythrocytes. Cyclic No specific N-terminal No specific C-terminal None L No cytotoxicity information found Not found 16075425 Chembiochem. 2005 Sep;6(9):1654-1662. "Appelt C, Wessolowski A, S?derh??ll JA, Dathe M, Schmieder P." "Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles." DRAMP03075 WNPFKELERAGQRVRDAIISAGPAVATVAQATALAK 36 Cecropin-D P01511 Belongs to the cecropin family Not found Antheraea pernyi (Chinese oak silk moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. PTM: C-terminal amidation." "Gram-negative bacteria: Escherichia coli D21 (MIC=0.37 ?M), E. coli D31 (MIC=0.21 ?M), Serratia marsescens (MIC=6.1 ?M), S. marsescens Strain 122 (MIC=75 ?M), Pseudomonas aeruginosa OT97 (MIC>81 ?M), Xenorhabdus nematophilus Xn21 (MIC=16 ?M);##Gram-positive bacteria: Bacillus subtilis Bsll (MIC>81 ?M), Bacillus megaterium Bmll (MIC=24 ?M), Bacillus thuringiensis Btll (MIC>81 ?M), Streptococcus fecalis Ds16 (MIC>81 ?M), S. fecalis AD-4 (MIC>81 ?M), Micrococcus luteus MI11 (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 6754375 Eur J Biochem. 1982 Sep;127(1):219-224. "Qu Z, Steiner H, Engstr?m A, Bennich H, Boman HG." "Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi." DRAMP03089 GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATAR 39 "Drosophila cecropin-A1/A2 (Insects, animals)" "P14954, B3DN02, B3DN08, O16815, O16816, O16817, O16818, O16819, O16820" Belongs to the cecropin family CecA1 AND CecA2 Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. Tissue specificity: Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria. Maximal expression in the adult involves fat body cells of the head, thorax and abdomen. Induction: Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food. PTM: C-terminal amidation (By similarity)." "Gram-negative bacteria: Escherichia coli D21 (MIC=0.3 ?M), Enterobacter cloacae 12 (MIC=0.4 ?M), Pseudomonas aeruginosa OT97 (MIC=2.2 ?M), Serratia marcescens Db11 (MIC=93 ?M);##Gram-positive bacteria: Bacillus megatherium Bm11 (MIC=2.6 ?M), Bacillus subtilis Bsll (MIC=16 ?M), Micrococcus luteus MI11 (MIC=8.5 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2104802##2390977##9725836 EMBO J. 1990 Jan;9(1):217-224.##EMBO J. 1990 Sep;9(9):2969-2976. "Kylsten P, Samakovlis C, Hultmark D.##Samakovlis C, Kimbrell DA, Kylsten P, Engstr?m A, Hultmark D." The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.##The immune response in Drosophila: pattern of cecropin expression and biological activity. DRAMP03090 GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR 39 "Drosophila cecropin B (CecB; Insects, animals)" "P14956, O16826, O16827, O16828, O18647, O61274, Q9V425" Belongs to the cecropin family CecB Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food. [Ref.1]" "Gram-negative bacteria: Escherichia coli D21 (MIC=1.8 ?M), Enterobacter cloacae b12 (MIC=1.0 ?M), Pseudomonas aeruginosa OT97 (MIC=4.2 ?M);##Gram-positive bacteria: Bacillus megatherium Bm11 (MIC=3.7 ?M), Bacillus subtilis Bsll (MIC=3.2 ?M), Micrococcus luteus MI11 (MIC=59 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2390977##2104802 EMBO J. 1990 Sep;9(9):2969-2976.##EMBO J. 1990 Jan;9(1):217-224. "Samakovlis C, Kimbrell DA, Kylsten P, Engstr?m A, Hultmark D.##Kylsten P, Samakovlis C, Hultmark D." The immune response in Drosophila: pattern of cecropin expression and biological activity.##The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection. DRAMP03095 VFIDILDKVENAIHNAAQVGIGFAKPFEKLINPK 34 "Andropin (Insects, animals)" "P21663, A9UNE4, O16822, O16823, O16824, Q6LAI1, Q9VA90" Not found Anp Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Andropin is constitutively expressed in the adult male ejaculatory duct in response to mating not bacterial infection. Andropin is less fungicidal than the cecropins (Insect Biochem Mol Biol. 1999;29:965-72). Along with other antimicrobial proteins, this peptide sterilizes the reproduction system of insects and protects sperms from being infected by bacteria (J Insect Physiol. 2001 Jun;47(6):617-622). Similarly, ceratotoxins are expressed in the female reproductive accesary glands and expressed during mating." "Gram-negative bacteria: Escherichia coli D21 (MIC=140 ?M), Enterobacter cloacae b312 (MIC>300 ?M), Pseudomonas aeruginosa OT97 (MIC>300 ?M), Serratia marcescens Db 11 (MIC>127 ?M), Serratia marcescens Db 1140 (MIC>127 ?M);##Gram-positive bacteria: Bacillus megatherium Bml1 (MIC=11 ?M), Bacillus subtilis Bs11 (MIC=17 ?M), Micrococcus luteus MIll (MIC=20 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1899226 EMBO J. 1991; 10:163-169. "Samakovlis, C, Kylsten, P, Kimbrell, DA, Engstroem, A, Hultmark, D." "The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster." DRAMP18495 QCRRLCYKQRCVTYCRGR 18 "Gomesin (Gm; Spiders, arachnids, Chelicerata, arthropods, invertebrates, animals)" P82358 Belongs to the tachyplesin family Not found Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic, Antimalarial, Antic" Protein level Beta sheet Not found 1KFP resolved by NMR. "Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. It shows hemolytic activity. Tissue specificity: In hemocytes only, but not in all hemocytes observed." "[Ref.10942757] Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 M), Bacillus cereus (MIC=6.25-12.5 M), Bacillus megaterium (MIC=0.2-0.4 M), Bacillus thuringiensis (MIC=1.6-3.15 M), Enterococcus faecalis (MIC=6.2-12.5 M), Listeria monocytogenes (MIC=0.8-1.6 M), Micrococcus luteus (MIC=0.4-0.8 M), Pediococcus acidolacrici (MIC=3.15-6.25 M), Staphylococcus aureus (MIC=1.6-3.15 M), Staphylococcus epidermidis (MIC=0.8-1.6 M), Staphylococcus haemolyticus (MIC=0.8-1.6 M), Staphylococcus saprophyticus (MIC=0.8-1.6 M), Streptococcus pyogenes (MIC=1.6-3.15 M), Nocardia asteroides (MIC=1.6-3.15 M);##Gram-negative bacteria: Escherichia coli 1106 (MIC=0.8-1.6 M), Escherichia coli D22 (MIC=0.4-0.8 M), Escherichia coli D31 (MIC=0.8-1.6 M), Escherichia coli SBS363 (MIC=0.4-0.8 M), Erwinia carolovora (MIC=3.15-6.25 M), Enterobacter cloacae 12 (MIC=3.15-6.25 M), Klebsiella pneumoniae (MIC=3.15-6.25 M), Pseudomonas aeruginosa (MIC=1.6-3.15 M), Salmonella thyphinurium (MIC=0.8-1.6 M), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 M);##Fungi: Alternaria brassicola (MIC=0.4-0.8 M), Aspergillus fumigatus (MIC=1.6-3.15 M), Beauveria bassiana (MIC=12.5-25 M), Fusarium culmorum (MIC=0.4-0.8 M), Fusarium oxysporum (MIC=0.4-0.8 M), Neurospora crassa (MIC=0.4-0.8 M), Nectria haematococca (MIC=0.2-0.4 M), Tricoderma viridae (MIC=0.4-0.8 M), Tricophvton mentagrophytes (MIC=0.8-1.6 M);##Yeasts: Candida albicans (MIC=0.15-0.3 M), Candida glabrata (MIC=12.5-25 M), Candida tropicalis (MIC=3.15-6.25 M), Cryptococcus neoformans (MIC=0.8-1.6 M), Saccharomyces cerevisiae (MIC=1.6-3.15 M)." [Ref.10942757] It exhibits 16% hemolysis at 1 M and 100 M against human erythrocytes Cyclic pyroglutamic acid Amidation "Disulfide bond between Cys2 and Cys15,Cys6 and Cys11." L No cytotoxicity information found Not found 10942757 J Biol Chem. 2000 Oct 27;275(43):33464-70. "Silva PI Jr, Daffre S, Bulet P." "Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family." DRAMP03104 ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN 40 "Sapecin (defensins; Insects, animals)" P18313 Belongs to the invertebrate defensin family (Type 1 subfamily) Not found Sarcophaga peregrina (Flesh fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Combine helix and strand structure Not found 1L4V resolved by NMR. "Function: Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria. Tissue specificity: Hemocytes and fat body. Induction: By injury to the larval cell wall. PTM: Contains three disulfide bonds 3-30; 16-36; 20-38." "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=5.0 ?g/ml), Staphylococcus smith (MIC=5.0 ?g/ml), Micrococcus luteus FDA16 (MIC=1.2 ?g/ml), Micrococcus luteus IF03333 (MIC=1.2 ?g/ml), Micrococcus luteus PC11001 (MIC=10.0 ?g/ml), Bacillus subtilis NRRI B-558 (MIC=39.0 ?g/ml), Bacillus subtilis PC1219 (MIC=20.0 ?g/ml), Mycobacterium smegmatis ATCC607 (MIC=78.0 ?g/ml), Corynebacterium bouis 1810 (MIC=2.5 ?g/ml), Corynebacterium michiganense (MIC=2.5 ?g/ml).##Gram-negative bacteria: Xantbmonas oryzae (MIC=20.0 ?g/ml), Pseudomonas lachrymans (MIC=78.0 ?g/ml), Escherichia coli NIHJ (MIC>78.0 ?g/ml), Shigella sonnei JS11746 (MIC>78.0 ?g/ml), Proteus vulgaris O X19 (MIC>78.0 ?g/ml) " No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys3 and Cys30; Cys16 and Cys36; Cys20 and Cys38. L No cytotoxicity information found Not found 3182836##3182836##2358424 J Biol Chem. 1988 Nov 15;263(32):17117-17121.##J Biol Chem. 1988 Nov 15;263(32):17112-17116.##J Biochem. 1990 Apr;107(4):514-518. "Matsuyama K, Natori S.##Matsuyama K, Natori S.##Kuzuhara T, Nakajima Y, Matsuyama K, Natori S." "Molecular cloning of cDNA for sapecin and unique expression of the sapecin gene during the development of Sarcophaga peregrina.##Purification of three antibacterial proteins from the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina.##Determination of the disulfide array in sapecin, an antibacterial peptide of Sarcophaga peregrina (flesh fly)." DRAMP03116 SLGGVISGAKKVAKVAIPIGKAVLPVVAKLVG 32 "Ceratotoxin-C (Insects, animals)" Q17313 Not found CTXC1 AND CTCX2 Ceratitis capitata (Mediterranean Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Has hemolytic activity.Temperature dependence: Thermostable. Still active at 100 degrees Celsius. "[Ref.9569644]Gram-negative bacteria: Escherichia coli 23739 (MIC=13.6 ?M), Escherichia coli LE 392 (MIC=5 ?M), Pseudomonas aeruginosa 27853 (MIC>50 ?M), P. vulgaris 6380 (MIC>50 ?M), S. typhymurium 23853 (MIC>5 ?M);##Gram-positive bacteria: E. cloacae 13047 (MIC>5 ?M), E. jaecalis 29212 (MIC>50 ?M), Staphylococcus aureus 25923 (MIC>50 ?M), B. cereus 9634 (MIC>5 ?M), Bacillus subtilis 6633 (MIC=5.9 ?M)." [Swiss_Prot Entry Q17313]has hemolytic activity Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9569644 Eur. J. Biochem. 1996; 241:330-337. "Rosetto M, Manetti AGO, Giordano PC, Marri L, Amons R, Baldari CT, Marchini D, Dallai R." "Molecular characterization of ceratotoxin C, a novel antibacterial female-specific peptide of the ceratotoxin family from the medfly Ceratitis capitata." DRAMP03117 QSEAGWLKKIGKKIERVGQHTRDATIQGLGVAQQAPNVAATAR 43 "Drosophila cecropin-A1 (Insects, animals)" O61272 Belongs to the cecropin family CecA1 Drosophila simulans (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None "Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. PTM: C-terminal amidation (By similarity)." "Gram-negative bacteria: Alcaligenes faecalis (MIC=10-25 ?M), Escherichia coli 1106 (MIC=0.25-0.5 ?M), Escherichia coli D22 (MIC=0.1-0.25 ?M), Escherichia coli D31 (MIC=0.1-0.25 ?M), Escherichia coli SBS363 (MIC=0.1-0.25 ?M), Enterobacter cloacae 12 (MIC=0.5-1 ?M), Erwinia carotovora (MIC=0.5-1 ?M), Klebsiella pneumoniae (MIC=1-2.5 ?M), Pseudomonas aeruginosa (MIC=1-2.5 ?M), Salmonella typhimurium (MIC=0.5-1 ?M), Xanthomonas campestris (MIC=0.5-1 ?M); ##Gram-positive bacteria: Aerococcus viridans (MIC=5-10 ?M), Bacillus megaterium (MIC=1-2.5 ?M), Micrococcus luteus (MIC=5-10 ?M).##Fungi: Botrytis cinerea (MIC=5-10 ?M), Fusarium culmorum (MIC=1-2.5 ?M), Fusarium oxysporum (MIC=1-2.5 ?M), Neurospora crassa (MIC=2.5-10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9553148##9725836 Immunogenetics. 1998 May;47(6):417-429.##Genetics. 1998 Sep;150(1):157-171.##Insect Mol Biol. 2000 Feb;9(1):75-84. "Date A, Satta Y, Takahata N, Chigusa S.I.##Ramos-Onsins S, Aguade M.##Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, Mller HM, Dimopoulos G, Hoffmann J, Kafatos FC, Richman A." "Evolutionary history and mechanism of the Drosophila cecropin gene family.##Molecular evolution of the Cecropin multigene family in Drosophila: functional genes vs pseudogenes.##Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae." DRAMP03138 GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL 34 "Cecropin-A (Insects, animals)" "P82592, Q17NR3, Q95PI9" Belongs to the cecropin family CECA Aedes aegypti (Yellowfever mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli D22 (MIC=0.25-0.5 ?g/ml), E. coli D31 (MIC=0.25-0.5 ?g/ml), E. coli SBS363 (MIC=0.1-0.25 ?g/ml), E. coli 1106 (MIC=0.25-0.5 ?g/ml), Enterobacter cloacae b12 (MIC=50-100 ?g/ml), E. carotovora (MIC=0.25-0.5 ?g/ml), Klebsiella pneumoniae (MIC=1-2.5 ?g/ml), Pseudomonas aeruginosa (MIC=10-25 ?g/ml), Salmonella typhimurium (MIC=1-2.5 ?g/ml), X. campestris (MIC=0.5-1 ?g/ml);##Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 ?g/ml), Bacillus megaterium (MIC=1-2.5 ?g/ml), Micrococcus luteus (MIC=10-25 ?g/ml), Streptococcus pyogenes (MIC=10-25 ?g/ml).##Fungi: Fusarium culmorum (MIC=1-2.5 ?g/ml), Fusarium oxysporum (MIC=2.5-5 ?g/ml), Neurospora crassa (MIC=5-10 ?g/ml), Candida albicans (MIC=25-50 ?g/ml), Cryptococcus neoformans (MIC=25-50 ?g/ml), Saccharomyces cerevisiae (MIC=50-100 ?g/ml) " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10400619 J Biol Chem. 1999 Jul 16;274(29):20092-20097. "Lowenberger C, Charlet M, Vizioli J, Kamal S, Richman A, Christensen BM, Bulet P." "Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti." DRAMP03140 GRLKKLGKKIEGAGKRVFKAAEKALPVVAGVKALG 35 "Anopheles cecropin-A amidated isoform (Insects, animals)" "P82290, A7XAX5, A7XAX7, A7XAY1, A7XAY8, A7XAZ7, A7XB12, A7XB23, Q7QEE3" Belongs to the cecropin family CecA Anopheles gambiae (African malaria mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antibacterial activity against several Gram-positive and Gram-negative bacteria. Also has antifungal activity. Tissue specificity: Relatively abundant in head, thorax and to a lesser extent in abdominal carcass and anterior midgut. Developmental stage: In young pupae, expressed within 2 hours of infection and continued to accumulate over 16 hours. Induction: By bacterial infection. PTM: C-terminal amidation." "Gram-negative bacteria: Alcaligenes faecalis (MIC=1-2.5 ?M), Escherichia coli 1106 (MIC=0.5-1 ?M), E. coli D22 (MIC=0.1-0.25 ?M), E. coli D31 (MIC=0.1-0.25 ?M), E. coli SBS363 (MIC=0.05-0.1 ?M), Enterobacter cloacae 12 (MIC=0.5-1 ?M), Erwinia carotovora (MIC=0.5-1 ?M), Klebsiella pneumoniae (MIC=1-2.5 ?M), Pseudomonas aeruginosa (MIC=1-2.5 ?M), Salmonella typhimurium (MIC=0.1-0.25 ?M), Xanthomonas campestris (MIC=0.5-1 ?M); ##Gram-positive bacteria: Aerococcus viridans (MIC=0.5-1 ?M), Bacillus cereus (MIC=50-100 ?M), Bacillus megaterium (MIC=0.5-1 ?M), Listeria monocytogenes (MIC=50-100 ?M), Micrococcus luteus (MIC=0.5-1 ?M), Staphylococcus aureus (MIC=50-100 ?M), Staphylococcus epidermidis (MIC=10-25 ?M), Staphylococcus haemolyticus (MIC=1-2.5 ?M), Staphylococcus saprophyticus (MIC=1-2.5 ?M), Streptococcus pyogenes (MIC=0.1-0.25 ?M).##Fungi: Aspergillus fumigatus (MIC=5-10 ?M), Botrytis cinerea (MIC=1-2.5 ?M), Fusarium culmorum (MIC=0.5-1 ?M), Fusarium oxysporum (MIC=1-2.5 ?M), Neurospora crassa (MIC=1-2.5 ?M), Candida albicans (MIC=1-2.5 ?M), Cryptococcus neoformans (MIC=5-10 ?M), Saccharomyces cerevisiae (MIC=25-50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10672074##12421409 Insect Mol Biol. 2000 Feb;9(1):75-84.##Insect Mol Biol. 2002 Dec;11(6):517-525. "Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, Mller HM, Dimopoulos G, Hoffmann J, Kafatos FC, Richman A.##Zheng XL, Zheng AL." "Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae.##Genomic organization and regulation of three cecropin genes in Anopheles gambiae." DRAMP03150 MVFAYAPTCARCKSIGARYCGYGYLNRKGVSCDGQTTINSCEDCKRKFGRCSDGFITECFL 61 "Gambicin (Insects, animals)" No entry found Not found Not found Anopheles albimanus (mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic" Not found Bridge Not found None "Function: In vitro experiments showed that the 6.8-kDa mature peptide can kill both Gram-positive and Gram-negative bacteria, has a morphogenic effect on a filamentous fungus, and is marginally lethal to Plasmodium berghei ookinetes. Induction: Predominantly expressed in the anterior part. PTM: Contains four disulfide bridges." Gram-negative bacterium: E. coli (MIC=6.25-12.5 ?M);##Gram-positive bacterium: M. luteus (MIC=25-50 ?M).##Fungus: N. crassa. No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys9 and Cys20; Cys12 and Cys32; Cys41 and Cys51,Cys44 and Cys59." L No cytotoxicity information found Not found 11606751 Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12630-5. "Vizioli J, Bulet P, Hoffmann JA, Kafatos FC, Mller HM, Dimopoulos G." Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae. DRAMP03153 GIGGKPVQTAFVDNDGIYD 19 27 kDa antibacterial protein P81925 Not found Not found Cyprinus carpio (common carp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Has antibacterial activity. Forms large ion channels responsible for disrupting the cellular envelope of bacteria leading to cell lysis. "Gram-positive bacteria: Staphylococcus aureus (MIC=5 ?g/ml), Micrococcus luteus (MIC=0. 5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=5 ?g/ml), Pseudomonas fluorescens (MIC=10 ?g/ml), Aeromonas hydrophila (MIC=5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 8797847 Eur J Biochem. 1996 Aug 15;240(1):143-149. "Lema??tre C, Orange N, Saglio P, Saint N, Gagnon J, Molle G." Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio). DRAMP03166 IRNSLTCRFNFGICLPKRCPGRMRQIGTCF 30 "P15 (deer beta-defensin; ruminant, animals)" No entry found Not found Not found Cervus elaphus (New Zealand deer) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: It shows strong activity against Gram-negative bacteria, but lesser activity against Gram-positive bacteria and yeast. Caution: the sequence displayed is N-terminal sequence of P15. " Gram-negative bacterium: Escherichia coli O111 (MIC=0.3 ?g/mL);##Gram-positive bacterium: Staphylococcus aureus NCTC 4163 (MIC=1 ?g/mL).##Fungi: Candida albicans 3135A (MIC=3 ?g/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16011891 Int J Antimicrob Agents. 2005 Aug;26(2):165-169. "Treffers C, Chen L, Anderson RC, Yu PL." Isolation and characterisation of antimicrobial peptides from deer neutrophils. DRAMP03173 RWCVYAYVRVRGVLVRYRRCW 21 "Arenicin-1 (Ar-1; marine polychaeta, animals)" "Q5SC60, P84105" Not found Not found Arenicola marina (Lugworm) (Lumbricus marinus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Cytotoxic" Protein level Beta strand (2 strands; 16 residues) "Arenicin-1 is a two-stranded antiparallel -sheet (Cys3-Val10 and Val13-Cys20) stabilized by nine intra-backbone hydrogen bonds and a disulfide bond between Cys3 and Cys20. The strands of the -sheet are connected by a type I? -turn. The surface of arenicin is amphiphilic, with distinct hydrophobic and hydrophilic areas (ref.2)." 2JSB resolved by NMR. "Function: Has antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteriua as well as yeast C. albicans. Bacterial killing occurs within minutes and is accompanied by membrane permeabilization, membrane detachment and release of cytoplasm. Interaction of arenicin with reconstituted membranes that mimic the lipopolysaccharide-containing outer membrane or the phospholipid-containing plasma membrane of Gram-negative bacteria exhibited no pronounced lipid specificity. PTM: Contains one disulfide bond 3-20. Domian: Contains 1 BRICHOS domain." "Gram-positive bacterium: Listeria monocytogenes EGD (MIC=0.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35p (MIC=4 ?g/ml), E. coli WBB01 (MIC=0.3 mM), E. coli ATCC 23716 (MIC=0.6 mM), Salmonella enterica R595 (MIC=0.3 mM), S. enterica R60 (MIC=1.25 mM), Proteus mirabilis R45 (MIC=0.6 mM).##Yeast: Candida albicans 820 (MIC=20 ?g/ml).##Human Jurkat T-cells: LD50>40 mM (35.5% lysis at 30 mM)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys3 and Cys20. L "[Ref.27940358] Cytotoxicity: human embryonic fibroblasts (HEF) and human red blood cells (hRBC)(IC50 for arenicin-1 in the presence or absence of 10% FBS were of 35 and 8 M,HC50 indicating 50% hemolysis after 24 h incubation, equaled to 16M)." Anionic lipid vesicles 15527787##17935487 FEBS Lett. 2004 Nov 5;577(1-2):209-214.##Biochem J. 2008 Feb 15;410(1):113-122. "Ovchinnikova TV, Aleshina GM, Balandin SV, Krasnosdembskaya AD, Markelov ML, Frolova EI, Leonova YF, Tagaev AA, Krasnodembsky EG, Kokryakov VN.##Andr? J, Jakovkin I, Gr?tzinger J, Hecht O, Krasnosdembskaya AD, Goldmann T, Gutsmann T, Leippe M." "Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina.##Structure and mode of action of the antimicrobial peptide arenicin." DRAMP03181 HVDKKVADKVLLLKQLRIMRLLTRL 25 "Spinigerin (Insects, animals)" P82357 Not found Not found Pseudacanthotermes spiniger (Termite) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "1ZRW, 1ZRV resolved by NMR." Function: Active against Gram-positive bacteria and Gram-negative bacteria and fungi. "Gram-positive bacteria: Bacillus megaterium (MIC=0.8-1.5 ?M), Micrococcus luteus (MIC=0.8-1.5 ?M);##Gram-negative bacteria: Escherichia coli SBS363 (MIC=3-6 ?M), E. coli D22 (MIC=3-6 ?M), Klebsiella pneumoniae (MIC=50-100 ?M), Salmonella typhimurium (MIC=3-6 ?M), Pseudomonas aeruginosa (MIC=50-100 ?M).##Fungi: Trichoderma viride (MIC=1.5-3 ?M), Neurospora crassa (MIC=3-6 ?M), Fusarium culmorum (MIC=1.5-3 ?M), Nectria haematococca (MIC=0.4-0.8 ?M), Candida albicans (MIC=3-6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11053427##16170803 J Biol Chem. 2001 Feb 9;276(6):4085-4092.##Biopolymers. 2006 Feb 5;81(2):92-103. "Lamberty M, Zachary D, Lanot R, Bordereau C, Robert A, Hoffmann JA, Bulet P.##Landon C, Meudal H, Boulanger N, Bulet P, Vovelle F." "Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect.##Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation." DRAMP03186 SFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW 38 "Spheniscin-2 (Sphe-2; penguin avian beta-defensin 103b; birds ,animals)" P83430 Belongs to the beta-defensin family Not found Aptenodytes patagonicus (King penguin) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand (3 strands; 14 residues) "The overall fold of Sphe-2 includes a three-stranded antiparallel beta-sheet stabilized by three disulfide bridges with a pairing typical of beta-defensins. In addition, the N-terminal segment shows helical features on most structures.(Ref.2)" 1UT3 resolved by NMR. "Function: Has antimicrobial activity. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane Function: with its amphipathic structure. PTM: Contains three disulfide bond: 5-33; 12-27; 17-34. Preserving food in the bird somach for several weeks during egg incubation. The disulfide bond pattern is identical to canonical beta-defensins from mammals. The high potency is related to its high cationicity as well as a hydrophobic patch, which is not observed in mammalian defensins. " "[Ref.14525994]Gram-positive bacteria: Micrococcus luteus (MIC=1.5-3.0 ?M), Bacillus subtilis (MIC=0.8-1.5 ?M), Bacillus cereus ATCC 11778 (MIC=3-6 ?M), Bacillus megaterium (MIC=0.4-0.8 ?M), Staphylococcus aureus (MIC=1.5-3.0 ?M), Staphylococcus saprophyticus (MIC=1.5-3.0 ?M), Staphylococcus haemolyticus (MIC=1.5-3.0 ?M), Nocardia asteroides (MIC=0.8-1.5 ?M), Aerococcus viridans (MIC=0.4-0.8 ?M), Listeria monocytogenes (MIC=6-12 ?M);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=0.8-1.5 ?M), Escherichia coli 1106 (MIC=1.5-3.0 ?M), Salmonella typhimurium (MIC=6-12 ?M), Klebsiella pneumoniae (MIC=50-100 ?M), Pseudomonas aeruginosa ATCC 82118 (MIC=6-12 ?M), Vibrio metschnikovii NCTC 8483 (MIC=25-50 ?M), Vibrio anguillarum ATCC 19264 (MIC=25-50 ?M);##Fungi: Candida glabrata (MIC>100 ?M), Candida albicans IHEM 8060 (MIC=50-100 ?M), Candida tropicalis (MIC=1.5-3.0 ?M), Neurospora crassa (MIC=3-6 ?M),Aspergillus fumigatus (MIC=3-6 ?M)." It has hemolytic activity Cyclic Free Free Disulfide bonds between Cys5 and Cys33; Cys12 and Cys27; Cys17 and Cys34. L No cytotoxicity information found Not found 14525994##15123713 J Biol Chem. 2003 Dec 19;278(51):51053-51058.##J Biol Chem. 2004 Jul 16;279(29):30433-30439. "Thouzeau C, Le Maho Y, Froget G, Sabatier L, Le Bohec C, Hoffmann JA, Bulet P.##Landon C, Thouzeau C, Labb H, Bulet P, Vovelle F." "Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus.##Solution structure of spheniscin, a beta-defensin from the penguin stomach." DRAMP03187 QRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCR 36 "Beta defensin 1(BD-1; mammals, animals)" P83943 Belongs to the beta-defensin family DEFB1 Chinchilla lanigera (Long-tailed chinchilla) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial and antifungal activity. May have a role in maintaining sterility in the middle ear. Gram-negative bacterium: Moraxella catarrhalis (MIC=5 ?g/ml);##Gram-positive bacterium: Streptococcus pneumoniae (MIC=5 ?g/ml).##Fungi: Candida albicans (MIC=12.5-20 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14996845 J Biol Chem. 2004 May 7;279(19):20250-20256. "Harris RH, Wilk D, Bevins CL, Munson RS Jr, Bakaletz LO." Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway. DRAMP03198 ACYCRIPACFAGERRYGTCFYLGRVWAFCC 30 "Alpha-defensin PhD-4 (primates, mammals, animals)" P86724 Belongs to the alpha-defensin family Not found Papio hamadryas (Hamadryas baboon) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity in low salt conditions, and the antimicrobial activity decreases significantly at high physiological salt concentrations. PTM: Contains three disulfide bonds (By similarity)." "In low salt conditions: Gram-negative bacterium: E. coli ML35p (MIC=2.4 ?M),;##Gram-positive bacteria: Listeria monocytogenes EGD (MIC=2.2 ?M), methicillin-resistant S. aureus ATCC 33591 (MIC=3.5 ?M).##Fungi: Candida albicans 820 (MIC=3.9 ?M).##At high physiological salt concentrations: E. coli ML35p (MIC=7.1 ?M), L. monocytogenes EGD (MIC=1.8 ?M), S. aureus ATCC 33591 (MIC>50 ?M), Candida albicans 820 (MIC>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20155756 Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604. "Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R." De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. DRAMP03215 ZCRRLCYKQRCVTYCRGR 18 "Gomesin (Gm; spiders, Arthropods, animals)" "P82358, Q86RA2" Not found Not found Acanthoscurria gomesiana (Tarantula spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Protein level Beta strand "Gm adopts a well-defined -hairpin-like struc ture, and the disulfide bonds have been reported to be important for the maintenance of this structure." 1KFP resolved by NMR. "[Ref.10942757]Function: Gomesin bound to the cell surface of cryptococci neoformans, which resulted in cell death associated with membrane permeabilization (FEMS Microbiol Lett. 2007 Sep;274(2):279-86). Also, this peptide triggers SH-SY5Y cell death through L-type channel calcium influx, MAPK/ERK, PKC and PI3K signaling and generation of reactive oxygen species (Soletti RC et al 2010 Chem Biol Interact 186: 135-43). Although represented by E, the N-terminal residue is a pyroglutamate. In hemocytes only, but not in all hemocytes observed.##[Ref.28741926]Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.10942757]Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 ?M), Bacillus cereus (MIC=6.25-12.5 ?M), Bacillus megaterium (MIC=0.2-0.4 ?M), Bacillus thuringiensis (MIC=1.6-3.15 ?M), Enterococcus faecalis (MIC=6.2-12.5 ?M), Listeria monocytogenes (MIC=0.8-1.6 ?M), Micrococcus luteus (MIC=0.4-0.8 ?M), Pediococcus acidolacrici (MIC=3.15-6.25 ?M), Staphylococcus aureus (MIC=1.6-3.15 ?M), S. epidermidis (MIC=0.8-1.6 ?M), S. haemolyticus (MIC=0.8-1.6 ?M), S. saprophyticus (MIC=0.8-1.6 ?M), Streptococcus pyogenes (MIC=1.6-3.15 ?M), Nocardia asteroides (MIC=1.6-3.15 ?M);##Gram-negative bacteria: Alcaligenes faecalis (MIC>100 ?M), Escherichia coli 1106 (MIC=0.8-1.6 ?M), E. coli D22 (MIC=0.4-0.8 ?M), E. coli D31 (MIC=0.8-1.6 ?M), E. coli SBS363 (MIC=0.4-0.8 ?M), Erwinia carolovora carolovora (MIC=3.15-6.25 ?M), Enterobacter cloacae beta 12 (MIC=3.15-6.25 ?M), Klebsiella pneumoniae (MIC=3.15-6.25 ?M), Pseudomonas aeruginosa (MIC=1.6-3.15 ?M), Salmonella typhimurium (MIC=0.8-1.6 ?M), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 ?M).##Fungi: Alternaria brassicola (MIC=0.4-0.8 ?M), Aspergillus fumigatus (MIC=1.6-3.15 ?M), Beauveria bassiana (MIC=12.5-25 ?M), Fusarium culmorum (MIC=0.4-0.8 ?M), F. oxysporum (MIC=0.4-0.8 ?M), Neurospora crassa (MIC=0.4-0.8 ?M), Nectria haematococca (MIC=0.2-0.4 ?M), Tricoderma viridae (MIC=0.4-0.8 ?M), Tricophvton mentagrophytes (MIC=0.8-1.6 ?M), C. albicans (MIC=0.15-0.3 ?M), C. glabrata (MIC=12.5-25 ?M), C. tropicalis (MIC=3.15-6.25 ?M), C. neoformans (MIC=0.8-1.6 ?M), Saccharomyces cerevisiae (MIC=1.6-3.15 ?M).##[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 M), Klebsiella pneumoniae ATCC 700603 (MIC=32 M), Acinetobacter baumannii ATCC 19606 (MIC=4-8 M), Pseudomonas aeruginosa ATCC 27853 (MIC=8 M), Helicobacter pylori ATCC 43504 (MIC>80 M);##Fungi : Candida albicans ATCC 90028 (MIC=8-16 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 M)" "[Ref.28741926] It has 0% hemolysis at 6 M , 3% hemolysis at 10 M , 10% hemolysis at 5 M , 41.2-53.2% hemolysis at 64 M , 50% hemolysis at 100 M against human red blood cells" Cyclic pyroglutamic acid Amidation "Disulfide bond between Cys2 and Cys15,Cys6 and Cys11." L "[Ref.28741926] CC50 = 67.0 5.0 M against CRL-1739, CC50 = 3.7 0.2 M against MM96L, CC50 = 49.9 16.6M against HFF-1, CC50 =54.15.0 M against HeLa, CC50 = 3.8 0.3 M against K-562." Not found 10942757##28741926 J Biol Chem. 2000 Oct 27;275(43):33464-33470.##ACS Chem Biol.?2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Silva PI Jr, Daffre S, Bulet P.##Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" "Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.##Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties" DRAMP03216 GIRCPKSWKCKAFKQRVLKRLLAMLRQHAF 30 "Oxyopinin-4a (Oxt-4a; spiders, Arthropods, animals)" "F8J4S0, P86350" Not found Not found Oxyopes takobius (Lynx spider) (Oxyopes foliiformis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found 2L3I resolved by NMR. "Function: Disrupts cell membranes through the formation of pores Probable. Has antibacterial activity. Has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: Contains one disulfide bond 4-10." [Ref.21933345]Gram-positive bacteria: S. aureus (MIC=10 ?M) and Bacillus subtilis (MIC=0.5 ?M);##Gram-negative bacteria: P. fluorescens (MIC=1 ?M) and E. coli (MIC=0.5 ?M). [Ref.21933345] EC50=7 M against human erythrocytes Cyclic Free Free Disulfide bond between Cys4 and Cys10. L No cytotoxicity information found Cell membrane (Probable) 21933345 FEBS J. 2011 Nov;278(22):4382-4393. "Dubovskii PV, Vassilevski AA, Samsonova OV, Egorova NS, Kozlov SA, Feofanov AV, Arseniev AS, Grishin EV." Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin. DRAMP03217 FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ 48 "M-oxotoxin-Ot1a (Oxyopinin-1, Oxki1; spiders, Arthropods, animals)" P83247 Not found Not found Oxyopes takobius (Lynx spider) (Oxyopes foliiformis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal" Protein level Alpha helix Not found None "Function: Disrupts cell membranes, particularly those rich in phosphocholine, through formation of pores. Has antimicrobial activity against Gram-negative bacterium E. coli, Gram-positive bacteria B. subtilis and S. aureus, and hemolytic activity against sheep erythrocytes. Has insecticidal activity against S. frugiperda ovarian cells by opening non-selective ion channels. Enhances the insecticidal activity of spider venom neurotoxic peptides." "[Ref.11976325]Gram-negative bacterium: Escherichia coli (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis, Staphylococcus aureus (MIC=6.2 ?M)." [Ref.11976325]100% hemolytic activity at 50 ?M against sheep red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11976325##15328050 J Biol Chem. 2002 Jun 28;277(26):23627-23637.##Biochim Biophys Acta. 2004 Aug 30;1664(2):182-188. "Corzo G, Villegas E, Gmez-Lagunas F, Possani LD, Belokoneva OS, Nakajima T.##Belokoneva OS, Satake H, Mal'tseva EL, Pal'mina NP, Villegas E, Nakajima T, Corzo G." "Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.##Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size." DRAMP03222 GFGALFKFLAKKVAKTVAKQAAKQGAKYVVNKQME 35 "M-ctenitoxin-Cs1a (M-CNTX-Cs1a; Cupiennin-1a; spiders, Arthropods, animals)" P83619 Belongs to the cupiennin family Not found Cupiennius salei (Wandering spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal" Protein level Alpha helix (3 helices; 11 residues) "The peptide adopts a helix-hinge-helix structure in a membrane mimicking solvent. The hinge may play a role in allowing the amphipathic N-terminal helix and polar C-terminal helix to orient independently upon membrane binding, in order to achieve maximal antibacterial efficacy.(Ref.2)" 2K38 resolved by NMR. "Function: Has antimicrobial activity. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane Function: with its amphipathic structure. Synergistically increases the insecticidal activity of CSTX-1, CSTX-9, and CSTX-13 by up to 65%. Also inhibits the formation of nitric oxide by neuronal nitric oxide synthase. LD50 is 5.9 pmol/mg on Drosophila. " "[Ref.11792701]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.31-0.63 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.31-0.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=0.31-0.63 ?M), Enterococcus faecalis ATCC 29212 (MIC=2.50-5.00 ?M)." [Ref.11792701]EC50=24.4 M against human red blood cells. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet calcium calmodulin 11792701##17319697 J Biol Chem. 2002 Mar 29;277(13):11208-11216.##Biochemistry. 2007 Mar 20;46(11):3576-3585. "Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W.##Pukala TL, Boland MP, Gehman JD, Kuhn-Nentwig L, Separovic F, Bowie JH." "Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).##Solution structure and interaction of cupiennin 1a, a spider venom peptide, with phospholipid bilayers." DRAMP03225 GFGSLFKFLAKKVAKTVAKQAAKQGAKYVANKHME 35 "M-ctenitoxin-Cs1d (M-CNTX-Cs1d; Cupiennin-1d; spiders, Arthropods, animals)" P83622 Belongs to the cupiennin family Not found Cupiennius salei (Wandering spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial activity. Has insecticidal activity. Probably acts by disturbing membrane Function: with its amphipathic structure. Tissue specificity: Expressed by the venom gland. Toxic dose: LD50 is 6.4 pmol/mg on Drosophila." "[Ref.11792701]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.08-0.16 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.16-0.31 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=0.63-1.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=1.25-2.50 ?M)." [Ref.11792701]Not determined Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11792701##10669026 J Biol Chem. 2002 Mar 29;277(13):11208-11216.##Toxicon. 2000 Mar;38(3):373-380. "Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W.##Haeberli S, Kuhn-Nentwig L, Schaller J, Nentwig W." "Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).##Characterisation of antibacterial activity of peptides isolated from the venom of the spider Cupiennius salei (Araneae: Ctenidae)." DRAMP03226 SMWSGMWRRKLKKLRNALKKKLKGE 25 "M-zodatoxin-Lt1a (M-ZDTX-Lt1a; Latarcin-1, Ltc-1, Ltc1; spiders, Arthropods, animals)" Q1ELT9 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 16 residues) The Ltc1 molecule is found to form a straight uninterrupted amphiphilic helix comprising 8-23 residues. The hydrophobic surface of the Ltc1 helix is narrow-shaped and extends with no gradient along the axis. (Ref.2) 2PCO resolved by NMR. "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.5 ?M), Bacillus subtilis VKM B-501 (MIC=1.0 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 ?M), Escherichia coli MH1 (MIC=0.7?M), Pseudomonas aeruginosa PAO1 (MIC=4.1 ?M);##Fungi: Pichia pastoris GS115 (MIC=17 ?M), Saccharomyces cerevisiae Y190 (MIC>33 ?M)." [Ref.16735513]20% hemolytic activity at 80 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513##18293934 J Biol Chem. 2006 Jul 28;281(30):20983-20992.##Biochemistry. 2008 Mar 18;47(11):3525-3533. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.##Dubovskii PV, Volynsky PE, Polyansky AA, Karpunin DV, Chupin VV, Efremov RG, Arseniev AS." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.##Three-dimensional structure/hydrophobicity of latarcins specifies their mode of membrane activity." DRAMP03227 GLFGKLIKKFGRKAISYAVKKARGKH 26 "M-zodatoxin-Lt2a (M-ZDTX-Lt2a; Latarcin-2a, Ltc-2a, Ltc2a; spiders, Arthropods, animals)" Q1ELU1 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (2 helices; 18 residues) The molecule of Ltc2a is found to consist of two helical regions (residues 3-9 and 13-21) connected via a poorly ordered fragment. 2G9P resolved by NMR. "Function: Has hemolytic activity against Rabbit erythrocytes and has toxicity to ovarian insect Sf9 cells (EC50=20 ?M). Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. " "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 ?M), Bacillus subtilis VKM B-501 (MIC=0.4 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 ?M), Escherichia coli MH1 (MIC=0.7 ?M), Pseudomonas aeruginosa PAO1 (MIC=6.7 ?M);##Fungi: Pichia pastoris GS115 (MIC=6.7 ?M), Saccharomyces cerevisiae Y190 (MIC=54 ?M)." [Ref.16735513]20% hemolytic activity at 6 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513##16939228 J Biol Chem. 2006 Jul 28;281(30):20983-20992.##Biochemistry. 2006 Sep 5;45(35):10759-10767. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.##Dubovskii PV, Volynsky PE, Polyansky AA, Chupin VV, Efremov RG, Arseniev AS." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.##Spatial structure and activity mechanism of a novel spider antimicrobial peptide." DRAMP03229 SWKSMAKKLKEYMEKLKQRA 20 "M-zodatoxin-Lt3a (M-ZDTX-Lt3a; Latarcin-3a, Ltc-3a; spiders, Arthropods, animals)" Q1ELU3 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 MIC=1.2 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=2.5 ?M), Escherichia coli MH1 (MIC=6.0 ?M), Pseudomonas aeruginosa PAO1 (MIC>40 ?M);##Fungi: Pichia pastoris GS115 (MIC=20 ?M), Saccharomyces cerevisiae Y190 (MIC=20 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03230 SWASMAKKLKEYMEKLKQRA 20 "M-zodatoxin-Lt3b (M-ZDTX-Lt3b; Latarcin-3b, Ltc-3b; spiders, Arthropods, animals)" Q1ELU2 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 ?M), Bacillus subtilis VKM B-501 (MIC=2.9 ?M);Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=23 ?M), Escherichia coli MH1 (MIC=28 ?M), Pseudomonas aeruginosa PAO1 (MIC>45 ?M);##Fungi: Pichia pastoris GS115 (MIC=23 ?M), Saccharomyces cerevisiae Y190 (MIC=23 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03231 GLKDKFKSMGEKLKQYIQTWKAKF 24 "M-zodatoxin-Lt4a (M-ZDTX-Lt4a; Latarcin-4a, Ltc-4a; spiders, Arthropods, animals)" Q1ELU5 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 (MIC=1.1 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=4.5 ?M), Escherichia coli MH1 (MIC=3.2 ?M), Pseudomonas aeruginosa PAO1 (MIC>35 ?M);##Fungi: Pichia pastoris GS115 (MIC=36 ?M), Saccharomyces cerevisiae Y190 (MIC=18 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03232 SLKDKVKSMGEKLKQYIQTWKAKF 24 "M-zodatoxin-Lt4b (M-ZDTX-Lt4b; Latarcin-4b, Ltc-4b; spiders, Arthropods, animals)" Q1ELU4 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 (MIC=1.1 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=4.4 ?M), Escherichia coli MH1 (MIC=4.4 ?M), Pseudomonas aeruginosa PAO1 (MIC>35 ?M);##Fungi: Pichia pastoris GS115 (MIC>35 ?M), Saccharomyces cerevisiae Y190 (MIC=35 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03233 GFFGKMKEYFKKFGASFKRRFANLKKRL 28 "M-zodatoxin-Lt5a (M-ZDTX-Lt5a; Latarcin-5, Ltc-5; spiders, Arthropods, animals)" Q1ELU9 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria and and yeasts. Also has hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland. PTM: Leucine amide at L28." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=1.1 ?M), Bacillus subtilis VKM B-501 (MIC=0.6 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=0.6 ?M), Escherichia coli MH1 (MIC=0.6 ?M), Pseudomonas aeruginosa PAO1 (MIC=18 ?M);##Fungi: Pichia pastoris GS115 (MIC>37 ?M), Saccharomyces cerevisiae Y190 (MIC>37 ?M)." [Ref.16735513]20% hemolytic activity at 40 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-20992. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV. " "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03236 GFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKYYGKKALQKASEKL 69 "M-zodatoxin-Lt8a (M-ZDTX-Lt8a; Cytoinsectotoxin-1a, CIT-1a; spiders, Arthropods, animals)" "P85253, B3W6H9" Belongs to the cytoinsectotoxin family cit 1-1 Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal" Protein level Not found Not found None "Function: Insecticidal, cytolytic and antimicrobial peptide. Has insecticidal activity against the flesh fly S. carnaria, and against the cockroach N. cinerea. CIT 1a Has hemolytic activity against human erythrocytes, and cytolytic activity against insect Sf9 cells in the same concentration range. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis. Tissue specificity: Expressed by the venom gland. Toxic dose: LD50 is 5 ?g/g for adult and 20 ?g/g for larvae of flesh fly S. carnaria. LD50 is 500 ?g/g for cockroach N. cinerea." "[Ref.18215128]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.5 ?M), Bacillus subtilis VKM B-501 (MIC=0.9 ?M), Micrococcus luteus (MIC>30 ?M), Staphylococcus aureus (MIC>30 ?M);##Gram-negative bacteria: Escherichia coli C600 (MIC=0.5 ?M), E. coli DH5alpha (MIC=0.9 ?M), E. coli MH1 (MIC=0.5 ?M), Pseudomonas aeruginosa PAO1 (MIC=1.9 ?M), Pseudomonas fluorescens VKM B-894 (MIC=3.8 ?M)." [Ref.18215128]EC50=6 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18215128 Biochem J. 2008 May 1;411(3):687-696. "Vassilevski A.A, Kozlov S.A, Samsonova O.V, Egorova N.S, Karpunin D.V, Pluzhnikov K.A, Feofanov A.V, Grishin E.V." "Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom." DRAMP03253 GKLQAFLAKMKEIAAQTL 18 "M-lycotoxin-Ls3a (M-LCTX-Ls3a; Lycocitin-1; spiders, Arthropods, animals)" P0C2U6 Not found Not found Lycosa singoriensis (Wolf spider) (Aranea singoriensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits growth of Gram-positive and Gram-negative bacteria and fungi. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis ATCC6633 (MIC=1.6-3.2 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=3.2-6.4 ?M), Pseudomonas aeruginosa.##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14991689 J Mass Spectrom. 2004 Feb;39(2):193-201. "Budnik BA, Olsen JV, Egorov TA, Anisimova VE, Galkina TG, Musolyamov AK, Grishin EV, Zubarev RA." De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis. DRAMP03254 GRLQAFLAKMKEIAAQTL 18 "M-lycotoxin-Ls3b (M-LCTX-Ls3b; Lycocitin-2; spiders, Arthropods, animals)" P0C2U7 Not found Not found Lycosa singoriensis (Wolf spider) (Aranea singoriensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits growth of Gram-positive and Gram-negative bacteria and fungi. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus 209P, Bacillus subtilis ATCC 6633 (MIC=1.57-3.14 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=3.14-6.29 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=5.02-10.05 ?M).##Fungi: Candida albicans. " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14991689 J Mass Spectrom. 2004 Feb;39(2):193-201. "Budnik BA, Olsen JV, Egorov TA, Anisimova VE, Galkina TG, Musolyamov AK, Grishin EV, Zubarev RA." De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis. DRAMP03278 IWLTALKFLGKHAAKHLAKQQLSKL 25 "M-lycotoxin-Hc1a (M-LCTX-Hc1a; Lycotoxin I; spiders, Arthropods, animals)" P61507 Not found Not found Hogna carolinensis (Carolina wolf spider) (Lycosa carolinensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. Is lethal to lepidopteran larvae. May Function: both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion." "Gram-positive bacteria: Bacillus thuringiensis subsp. Israelensis (MIC<5.0 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC=10-20 ?M), Escherichia coli DH5 (MIC=80-150 ?M).##Fungi: Candida glabrata ATCC 2001 (MIC=100-150 ?M), Candida albicans clinical isolate (MIC=100-200 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 9442044##18098329 J Biol Chem. 1998 Jan 23;273(4):2059-2066.##J Pept Sci. 2008 Apr;14(4):528-534. "Yan L, Adams ME.##Ad?o R, Seixas R, Gomes P, Pessoa JC, Bastos M." "Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.##Membrane structure and interactions of a short Lycotoxin I analogue." DRAMP03279 KIKWFKTMKSIAKFIAKEQMKKHLGGE 27 "M-lycotoxin-Hc2a (M-LCTX-Hc2a; Lycotoxin-2; Lycotoxin II; spiders, Arthropods, animals)" P61508 Not found Not found Hogna carolinensis (Carolina wolf spider) (Lycosa carolinensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. May Function: both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion." "Gram-positive bacteria: Bacillus thuringiensis subsp. Israelensis (MIC=10-60 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC<10 ?M), Escherichia coli DH5 (MIC<40 ?M).##Fungi: Candida glabrata ATCC 2001 (MIC=100-150 ?M)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 9442044##18098329 J Biol Chem. 1998 Jan 23;273(4):2059-2066.##J Pept Sci. 2008 Apr;14(4):528-534. "Yan L, Adams ME.##Ad?o R, Seixas R, Gomes P, Pessoa JC, Bastos M." "Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.##Membrane structure and interactions of a short Lycotoxin I analogue." DRAMP03280 ATYDGKCYKKDNICKYKAQSGKTAICKCYVKVCPRDGAKCEFDSYKGKCYC 51 AcAMP (A. clavatus antimicrobial peptide) No entry found Not found Not found Aspergillus clavatus ES1 "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Not found Not found Not found None "This basic, Cys-rich antifungal peptide is also active against bacteria. AcAMP was sensitive to proteolytic enzymes, stable between pH 5.0 and 10.0, and heat resistant (15 min at 100 degrees C). " "Gram-positive bacteria: Staphylococcus aureus (MIC=20 ?g/ml), Bacillus cereus (MIC=10 ?g/ml), Micrococcus luteus (MIC=10 ?g/ml), Enterococcus faecalis (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=30 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml).##Fungi: Aspergillus niger, Fusarium solani, Fusarium oxysporum." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20440534 J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-813. "Hajji M, Jellouli K, Hmidet N, Balti R, Sellami-Kamoun A, Nasri M." A highly thermostable antimicrobial peptide from Aspergillus clavatus ES1: biochemical and molecular characterization. DRAMP03285 LFCRKGTCHFGGCPAHLVKVGSCFGFRACCKWPWDV 36 "Ostricacin-1 (Beta-defensin 2; Birds, animals)" P85113 Belongs to the beta-defensin family Not found Struthio camelus (Ostrich) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None PTM: Contains three disulfide bonds 3-29; 8-23; 13-30. "Gram-positive bacteria: Staphylococcus aureus 1056-MRSA (MIC=1.25 ?g/ml), S. aureus NCTC 4163 (MIC=6.7 ?g/ml);##Gram-negative bacteria: Escherichia coli O157:H7 (MIC=0.96 ?g/ml), E. coli 0111 (MIC=6.7 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys3 and Cys29,Cys8 and Cys23,Cys13 and Cys30." L No cytotoxicity information found Not found 16459058 Biotechnol Lett 2001; 23: 207-210.##Int J Antimicrob Agents. 2006 Mar;27(3):229-235. "Yu, PL, Choudhury SD, Ahrens K.##Sugiarto H, Yu PL." "Purification and characterization of the antimicrobial peptide, ostricacin.##Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins." DRAMP03286 APGNKAECEREKGYCGFLKCSFPFVVSGKCSRFFFCCKNIW 41 "Ostricacin-2 (Beta-defensin 1; Birds, animals)" P85114 Belongs to the beta-defensin family Not found Struthio camelus (Ostrich) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None PTM: Contains three disulfide bonds 8-36; 15-30; 20-37. Gram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=1.25 ?g/ml);##Gram-negative bacterium: Escherichia coli O157:H7 (MIC=0.96 ?g/ml);##Yeast: Candida albicans 3153A (MIC=6.2 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys8 and Cys36,Cys15 and Cys30,Cys20 and Cys37." L No cytotoxicity information found Not found 16459058 Int J Antimicrob Agents. 2006 Mar;27(3):229-235. "Sugiarto H, Yu PL." Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins. DRAMP03287 IPRPLDPCIAQNGRCFTGICRYPYFWIGTCRNGKSCCRRR 40 "Ostricacin-3 (Beta-defensin 7; Birds, animals)" P85115 Belongs to the beta-defensin family Not found Struthio camelus (Ostrich) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None PTM: Contains three disulfide bonds 8-36; 15-30; 20-37. Gram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=2.78 ?g/ml);##Gram-negative bacterium: Escherichia coli O157:H7 (MIC=2.41 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys8 and Cys36,Cys15 and Cys30,Cys20 and Cys37." L No cytotoxicity information found Not found 16459058 Int J Antimicrob Agents. 2006 Mar;27(3):229-235. "Sugiarto H, Yu PL." Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins. DRAMP03288 LPVNEAQCRQVGGYCGLRICNFPSRFLGLCTRNHPCCSRVWV 42 "Ostricacin-4 (Beta-defensin 8; Birds, animals)" P85116 Belongs to the beta-defensin family Not found Struthio camelus (Ostrich) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None PTM: Contains three disulfide bonds 8-36; 15-30; 20-37. Gram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=11.48 ?g/ml);##Gram-negative bacterium: Escherichia coli O157:H7 (MIC=12.03 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys8 and Cys36,Cys15 and Cys30,Cys20 and Cys37." L No cytotoxicity information found Not found 16459058 Int J Antimicrob Agents. 2006 Mar;27(3):229-235. "Sugiarto H, Yu PL." Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins. DRAMP03311 RGFRKHFNKLVKKVKHTISETAHVAKDTAVIAGSGAAVVAAT 42 "Stomoxyn (Insects, animals)" Q8T9R8 Not found Not found Stomoxys calcitrans (Stable fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix (4 helices; 32 residues) "Stomoxyn adoptS a flexible random coil structure in water while both assume a stable helical structure in the presence of TFE. In 50% TFE, the structure of stomoxyn is typical of cecropins, including an amphipathic helix at the N-terminus and a hydrophobic C-terminus with helical features that probably fold in a helical conformation at higher TFE concentration. (Ref.2)" 1ZRX resolved by NMR. "Function: Has antimicrobial activity against most Gram-positive and Gram-negative bacteria, filamentous fungi and yeasts tested. Has trypanolytic effect on T.b.rhodesiense and hemolytic activity against bovine red blood cells. May play an important role in protecting the stored blood in the anterior midgut from microorganisms prior to digestion. Adopts an amphipathic alpha-helical structure only in the presence of an organic solvent that mimics a phospholipid membrane. Tissue specificity: Constitutively expressed in the adult anterior midgut; proventriculus, thoracic and reservoir regions." "[Ref.12372834]Gram-negative bacteria: Escherichia coli K12 RM148 (MIC=0.19-0.39 ?M), E. coli D22 (MIC=0.19-0.39 ?M), E. coli D31(MIC=0.19-0.39 ?M), E. coli SBS363 (MIC<0.19 ?M), E. coli 1106 (MIC=0.19-0.39 ?M), Enterobacter cloacae b12 (MIC=3.12-6.25 ?M), Erwinia carotovora (MIC=0.78-1.56 ?M), Klebsiella pneumoniae (MIC=0.78-1.56 ?M), Pseudomonas aeruginosa (MIC=0.39-0.78 ?M), Salmonella typhimurium (MIC=0.39-0.78 ?M), Xanthomonas campestris ( MIC=0.39-0.78 ?M);##Gram-positive bacteria: Aerococcus viridans (MIC=0.78-1.56 ?M), Bacillus megaterium (MIC=0.78-1.56 ?M), Bacillus subtilis (MIC=6.25-12.5 ?M), Enterococcus faecalis (MIC=0.78-1.56 ?M), Micrococcus luteus (MIC=0.78-1.56 ?M), Streptococcus pyogenes (MIC=1.56-3.12 ?M);##Fungi: Aspergillus fumigatus (MIC=50-100 ?M), Fusarium culmorum (MIC=0.39-0.78 ?M), Fusarium oxysporum (MIC=0.78-1.56 ?M), Nectria haematococca (MIC=0.39-0.78 ?M), N. crassa (MIC=3.12-6.25 ?M), Trichoderma viride (MIC=1.56-3.12 ?M), Trichophyton mentagrophytes (MIC=3.12-6.25 ?M), Candida albicans (MIC=25-50 ?M), C. glabrata (MIC=25-50 ?M), C. neoformans (MIC=0.78-1.56 ?M)." "[Ref.12372834]2% hemolytic activity at 10 M, 9% hemolytic activity at 100 M against bovine red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12372834##16170803 J. Biol. Chem. 2002; 277: 49921-49926.##Biopolymers. 2006 Feb 5;81(2):92-103. "Nathalie Boulanger, Rebecca J. L. Munks, Joanne V. Hamilton, Fran?oise Vovelle, Reto Brun, Mike J. Lehane, and Philippe Bulet.##Landon C, Meudal H, Boulanger N, Bulet P, Vovelle F." "Epithelial innate immunity. A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans.##Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation." DRAMP03312 VDKPDYRPRPRPPNM 15 "Metalnikowin-1 (Metalnikowin I; Insects, animals)" P80408 Not found Not found Palomena prasina (Green shield bug) (Cimex prasinus) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Rich Not found None "Function: Antibacterial peptide active against Gram-negative bacteria. Induction: By bacterial infection." "Gram-negative bacteria: Escherichia coli D22 (MIC=50-100 ?M), Salmonella typhimurium (MIC=50-100 ?M), Alcaligenes faecalis (MIC=50-100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available J. Insect Physiol. 1996; 42: 81-89. "Chernysh S, Cociancich S, Briand JP, Hetru C, Bulet P." The inducible antibacterial peptides of the hemipteran insect Palomena prasina: identification of a unique family of proline-rich peptides and of a novel insect defensin. DRAMP03370 QLINSPVTCMSYGGSCQRSCNGGFRLGGHCGHPKIRCCRRK 41 "Beta-defensin 6 (BD-6, mBD-6; Defensin, beta 6; Rodents, mammals, animals)" Q91VD6 Belongs to the beta-defensin family Defb6 Mus musculus (Mouse) "Antimicrobial, Antibacterial, Anti-Gram-" Transcript level Bridge Not found None "PTM: Contains three disulfide bonds 9-37; 16-30; 20-38. Predominantly expressed in skeletal muscle, also expressed in esophagus, tongue, and trachea. Also expressed in lung when induced by lipopolysaccharide. Expressed constitutively and induced by lipopolysaccharide (LPS)." Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=20 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys9 and Cys37,Cys16 and Cys30,Cys20 and Cys38." L No cytotoxicity information found Not found 11408484 J Biol Chem. 2001 Aug 24;276(34):31510-31514. "Yamaguchi Y, Fukuhara S, Nagase T, Tomita T, Hitomi S, Kimura S, Kurihara H, Ouchi Y." "A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle." DRAMP03405 GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE 33 "mCRAMP-1 (mouse cathelin-related antimicrobial peptide 1; cathelicidin; Rodents, mammals, animals" "P51437, Q0VB78" Not found Camp Mus musculus (Mouse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix (CD) The spectra of 10-25 ?m synthetic CRAMP-1 in buffer suggest that the peptide is in a random coil configuration and that it will assume a helical structure in the presence of 15C45% (v/v) trifluoroethanol. None "Function: Acts as a potent antimicrobial peptide. Tissue specificity: Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=2 ?M), Escherichia coli D21 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan I (MIC=32 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus aureus (MRSA) (MIC=64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=16 ?M), Streptococcus faecalis ATCC 29212 (MIC=16 ?M), Bacillus megaterium Bm11 (MIC=4 ?M).##Fungi: Candida albicans (MIC>64 ?M), Cryptococcus neoformans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9148921##8706928 J Biol Chem. 1997 May 16;272(20):13088-13093.##FEBS Lett. 1996 Aug 5;391(1-2):5-8. "Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R.##Popsueva AE, Zinovjeva MV, Visser JW, Zijlmans JM, Fibbe WE, Belyavsky AV." "Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse.##A novel murine cathelin-like protein expressed in bone marrow." DRAMP03406 ISRLAGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE 38 "mCRAMP-2 (mouse cathelin-related antimicrobial peptide 2; cathelicidin; Rodents, mammals, animals" "P51437, Q0VB78" Not found Camp Mus musculus (Mouse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix (CD) The CD spectra of CRAMP-2 (not shown) were similar to CRAMP-1. None "Function: Acts as a potent antimicrobial peptide. Tissue specificity: Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=2 ?M), Escherichia coli D21 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan I (MIC=32 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus aureus (MRSA) (MIC=64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=16 ?M), Streptococcus faecalis ATCC 29212 (MIC=32 ?M), Bacillus megaterium Bm11 (MIC=4 ?M).##Fungi: Candida albicans (MIC>64 ?M), Cryptococcus neoformans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9148921##8706928 J Biol Chem. 1997 May 16;272(20):13088-13093.##FEBS Lett. 1996 Aug 5;391(1-2):5-8. "Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R.##Popsueva AE, Zinovjeva MV, Visser JW, Zijlmans JM, Fibbe WE, Belyavsky AV." "Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse.##A novel murine cathelin-like protein expressed in bone marrow." DRAMP03419 VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR 32 "Neutrophil antibiotic peptide NP-1 (RatNP-1; Rodents, mammals, animals)" Q62716 Belongs to the alpha-defensin family Not found Rattus norvegicus (Rat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Comment: Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus." "Gram-positive bacterium: Staphylococcus aureus 502A [18 h] (MIC<100 cfu/ml);##Gram-negative bacterium: Escherichia coli ML-35 [18 h] (MIC<100 cfu/ml).##Fungi: Candida albicans 820 [18 h] (MIC<100 cfu/ml), Cryptococcus neoformans A-383 [18 h] (MIC=1.7 x 102 cfu/ml). " No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30." L No cytotoxicity information found Not found 2543629##7594610 Infect. Immun. 1989;57:2021-2027.##J. Immunol. 1995;155:4476-4484. "Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Selsted M.E, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E." Purification and antimicrobial properties of three defensins from rat neutrophils.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. DRAMP03422 ACYCRIGACVSGERLTGACGLNGRIYRLCCR 31 "Neutrophil antibiotic peptide NP-4 (RatNP-4; Rodents, mammals, animals)" Q62714 Belongs to the alpha-defensin family Np4 Rattus norvegicus (Rat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Bridge Not found None "Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus." "Gram-positive bacterium: Staphylococcus aureus 502A (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35, Acinetobacter calcoaceticus (MIC=50 ?g/ml).Fungi: Cryptococcus neoformans (MIC=10 ?g/ml), Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29." L No cytotoxicity information found Not found 2543629##7594610 Infect. Immun. 1989;57:2021-2027.##J. Immunol. 1995;155:4476-4484. "Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Selsted M.E, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E." Purification and antimicrobial properties of three defensins from rat neutrophils.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. DRAMP03464 GLLNGLALRLGKRALKKIIKRLCR 24 "Cryptonin (Insects, animals)" P85028 Not found Not found Cryptotympana dubia (Korean horse cicada) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None Function: Has very low hemolytic activity on rat erythrocytes. "[Ref.18000874]Gram-positive bacteria: Bacillus subtilis KCTC 3086 (MIC=3.12 ?g/ml), Staphylococcus aureus KCTC 1928 (MIC=25 ?g/ml), Micrococcus luteus KCTC 3063 (MIC=1.56 ?g/ml), Staphylococcus aureus (MRSA) (MIC=25 ?g/ml), VRE (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli K12-594 (MIC=3.12 ?g/ml);##Fungi: Candida albicans KCTC 7965 (MIC=50 ?g/ml), Candida tropicalis KCTC 1925 (MIC=3.12 ?g/ml)." [Ref.18000874]<5% hemolytic activity at 25-200 ?g/ml against rat erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18000874 Arch Insect Biochem Physiol. 2007 Dec;66(4):204-213. "Leem JY, Park DS, Suh EY, Hur JH, Oh HW, Park HY." "Isolation and functional analysis of a 24-residue linear alpha-helical antimicrobial peptide from Korean blackish cicada, Cryptotympana dubia (Homoptera)." DRAMP03467 PAQPFRFPKHPQGPQTRPPI 20 Antibacterial napin (Plants) P84529 Belongs to the 2S seed storage albumins family Not found Brassica rapa subsp. chinensis (Pak-choi) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: The small, basic, water-soluble napins are one of the two major kinds of storage proteins synthesized in the seed during its maturation. Inhibits cell-free protein synthesis. Has antibacterial activity against Gram-negative bacterium P. fluorescens, and the Gram-positive bacteria B. subtilis, B. cereus, B. megaterium and M. phei. No antibacterial activity against the Gram-positive bacterium S. aureus or the Gram-negative bacteria E. coli, E. aerogenes and P. aeruginosa. Subunit structure: The mature protein consists of a small and a large chain linked by disulfide bonds." "Gram-negative bacterium: Pseudomonas fluorescens (MIC=663.7 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=23610.2 ?M), Bacillus cereus (MIC=2229.1 ?M), Bacillus megaterium (MIC=2156.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15062997 Peptides. 2004 Feb;25(2):171-176. "Ngai PH, Ng TB." "A napin-like polypeptide from dwarf Chinese white cabbage seeds with translation-inhibitory, trypsin-inhibitory, and antibacterial activities." DRAMP03471 GFGCPGNQLKCNNHCKSISCRAGYCDAATLWLRCTCTDCNGKK 43 "Recombinant Crassostrea Gigas Defensin (Cg-Def; molluscs, animals)" Q4GWV4 Not found def Crassostrea gigas (Pacific oyster) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Combine helix and strand structure Not found 2B68 resolved by NMR. Function: Has antibacterial activity (By similarity). "Gram-positive bacteria: Micrococcus lysodeikticus (MIC=0.005-0.01 ?M), Staphylococcus aureus (MIC=1.25-2.5 ?M), Microbacterium maritypicum (MIC=0.5-1 ?M), Bacillus megaterium (MIC>20 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC=35-20 ?M), Vibrio alginolyticus (MIC>20 ?M), Salmonella typhimurium (MIC>20 ?M).##Fungi: Fusarium oxysporum (MIC=9-4.5 ?M), Botrytis cinerea (MIC>20 ?M), Penicillium crustosum (MIC>20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid II 16246846 J Biol Chem. 2006 Jan 6;281(1):313-323. "Gueguen Y, Herpin A, Aumelas A, Garnier J, Fievet J, Escoubas JM, Bulet P, Gonzalez M, Lelong C, Favrel P, Bachre E." "Characterization of a defensin from the oyster Crassostrea gigas. Recombinant production, folding, solution structure, antimicrobial activities, and gene expression." DRAMP03472 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 74 cgUbiquitin No entry found Not found Not found Crassostrea gigas (Pacific oyster) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Combine helix and strand structure "According to the homology modeling, this peptide is composed of three secondary structural motifs including three -helices and four -strands separated by 7 loops regions." None "Function: cgUbiquitin shows broad potent antimicrobial activity against Gram-positive and -negative bacteria, without hemolytic activity." "[Ref.22858580]Gram-positive bacteria: B. subtilis KCTC1021 (MIC=0.4 ?M), S. aureus RM4220 (MIC=4.7 ?M), S. iniae FP5229 (MIC=0.9 ?M);##Gram-negative bacteria: E. coli D31 (MIC=0.2 ?M), E. coli ML35p (MIC=1.4 ?M), P. aeruginosa KCTC2004 (MIC=0.6 ?M), S. flexneri KCTC2517 (MIC=0.7 ?M), S. sonnei KCTC2009 (MIC=1.2 ?M), A. hydrophila KCTC2358 (MIC=0.7 ?M), V. parahemolyticus KCCM41664 (MIC=1.1 ?M);##Yeast: C. albicans KCTC7965 (MIC=9.4 ?M)." [Ref.22858580]Non-hemolytic against human red blood cells up to 100 g/mL Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22858580 Mol Immunol. 2013 Jan;53(1-2):88-98. "Seo JK, Lee MJ, Go HJ, Kim GD, Jeong HD, Nam BH, Park NG." "Purification and antimicrobial function of ubiquitin isolated from the gill of Pacific oyster, Crassostrea gigas." DRAMP03486 GKIPVKAIKQAGKVIGKGLRAINIAGTTHDVVSFFRPKKKKH 42 "Manduca Sexta Moricin (MS moricin; Insects, animals)" Q86MA1 Not found Not found Manduca sexta (Tobacco hornworm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix (1 helices; 31 residues) The tertiary structure is composed of an eight-turn alpha-helix spanning almost the entire peptide. Insights of relationships between the structure and function are also presented. (Ref.1) 2JR8 resolved by NMR. "Function: Exhibits potent antimicrobial activities against a broad spectrum of Gram-positive and Gram-negative bacteria with a minimum inhibitory concentration of 1.4 microM. Tissue specificity: expressed in Manduca sexta fat body." "Gram-negative bacteria: Klebsiella pneumoniae (MIC=6.25 ?g/ml), Salmonella typhimurium (MIC=6.25 ?g/ml), S. typhimurium DT104 (MIC=6.25 ?g/ml), Escherichia coli O157:H7 (MIC=6.25 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25 923 (MIC=6.25 ?g/ml), Methicillin-resistant S. aureus ATCC 43 300 (MIC=6.25 ?g/ml), Methicillin-resistant S. aureus ATCC BAA-39 (MIC=12.5 ?g/ml), Listeria monocytogenes (MIC=6.25 ?g/ml).##NOTE: MIC is de??ned as the lowest peptide concentration that gives no visible growth after overnight incubation in 100% Muller-Hinton broth." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18265434##12706633 J Pept Sci. 2008 Jul;14(7):855-863.##Insect Biochem Mol Biol. 2003 May;33(5):541-59. "Dai H, Rayaprolu S, Gong Y, Huang R, Prakash O, Jiang H.##Zhu Y, Johnson TJ, Myers AA, Kanost MR." "Solution structure, antibacterial activity, and expression profile of Manduca sexta moricin.##Identification by subtractive suppression hybridization of bacteria-induced genes expressed in Manduca sexta fat body." DRAMP03507 KWKIFKKIEKVGRNIRNGIIKAGPAVAVLGEAKAL 35 "Cecropin-B (Insects, animals)" P01509 Belongs to the cecropin family Not found Antheraea pernyi (Chinese oak silkmoth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.36 ?M), Escherichia coli D31 (MIC=0.30 ?M), Serratia marsescens (MIC=2.6 ?M), Serratia marsescens Strain 122 (MIC=12 ?M), Pseudomonas aeruginosa OT97 (MIC=2.9 ?M), Xenorhabdus nematophilus Xn21 (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis Bsll (MIC=17 ?M), Bacillus megaterium Bmll (MIC=0.64 ?M), Bacillus thuringiensis Btll (MIC>88 ?M), Streptococcus fecalis Ds16 (MIC>88 ?M), Streptococcus fecalis AD-4 (MIC>88 ?M), Micrococcus luteus MI11 (MIC=0.29 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 6754375##2962676 Eur J Biochem. 1982 Sep;127(1):219-224.##Biomed Environ Mass Spectrom. 1987 Nov;14(11):669-673. "Qu Z, Steiner H, Engstr?m A, Bennich H, Boman HG.##Craig AG, Engstr?m A, Bennich H, Kamensky I." "Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi.##Plasma desorption mass spectrometry coupled with conventional peptide sequencing techniques." DRAMP03513 KVNVNAIKKGGKAIGKGFKVISAASTAHDVYEHIKNRRH 39 "G. mellonella moricin-like peptide A (Gm-mlpA; Insects, animals; Predicted)" A5JSU5 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=10 ?M).##Fungi: Fusarium graminearum mycelia (MIC=70 ?M), F;##Graminearum spores (MIC=0.7 ?M), Fusarium oxysporum mycelia (MIC=7 ?M), F. oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=7 ?M), Leptosphaeria maculans spores (MIC=7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03514 GKIPVKAIKKGGQIIGKALRGINIASTAHDIISQFKPKKKKNH 43 "G. mellonella moricin-like peptide B (Gm-mlpB; Insects, animals; Predicted)" A5JSU6 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), F;##Graminearum mycelia (MIC=280 ?M), Fusarium oxysporum spores (MIC=100 ?M), F. oxysporum mycelia (MIC=280 ?M), Leptosphaeria maculans spores (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03515 KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRH 38 "Moricin-like peptide C1 (Gm-mlpC1; Insects, animals; Predicted)" A5JSU7 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=1 ?M), Fusarium oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=100 ?M), Leptosphaeria maculans spores (MIC=6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03516 KVPIGAIKKGGKIIKKGLGVLGAAGTAHEVYNHVRNRQ 38 "Moricin-like peptide C2 (Gm-mlpC2; Insects, animals; Predicted)" A5JSU8 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=1 ?M), Fusarium oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=100 ?M), Leptosphaeria maculans spores (MIC=8 ?M), Fusarium graminearum mycelia (MIC=8 ?M), Fusarium oxysporum mycelia (MIC=8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03517 KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRQ 38 "Moricin-like peptide C3 (Gm-mlpC3; Insects, animals; Predicted)" A5JSU9 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), Fusarium oxysporum spores (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03518 KVPVGAIKKGGKAIKTGLGVVGAAGTAHEVYSHIRNRH 38 "Moricin-like peptide C4/C5 (Gm-mlpC4/C5; Insects, animals; Predicted)" A5JSV1 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03519 KGIGSALKKGGKIIKGGLGALGAIGTGQQVYEHVQNRQ 38 "Moricin-like peptide D (Gm-mlpD; Insects, animals; Predicted)" A5JSV2 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=10 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), Fusarium oxysporum spores (MIC=100 ?M), Ascochyta rabiei spores(MIC=100 ?M), Leptosphaeria maculans spores (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03532 AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH 42 "Moricin-1 (Insects, animals)" P82818 Belongs to the moricin family MOR1 Bombyx mori (Silk moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix (1 helices; 30 residues) "The solution structure reveals an unique structure comprising of a long alpha-helix containing eight turns along nearly the full length of the peptide except for four N-terminal residues and six C-terminal residues. The electrostatic surface map shows that the N-terminal segment of the alpha-helix, residues 5-22, is an amphipathic alpha-helix with a clear separation of hydrophobic and hydrophilic faces, and that the C-terminal segment o" 1KV4 resolved by NMR. Function: Has antibacterial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure. "Gram-negative bacteria: Escherichia coli JM109 (MIC=0.31 ?M), Acinetobacter sp. NISL B-4653 (MIC=0.27 ?M), Pseudomonas fluorescens IAM1179 (MIC=0.53 ?M), Pseudomonas aeruginosa IAM15140 (MIC=0.81 ?M);##Gram-positive bacteria: Bacillus subtilis IAM1107 (MIC=0.19 ?M), Bacillus megaterium IAM1030 (MI=0.09 ?M), Bacillus cereus IFO3457 (MIC=0.38 ?M), Staphylococcus aureus ATCC6538P (MIC=0.21 ?M), Staphylococcus aureus ATCC6538P (MIC=0.22 ?M), Staphylococcus aureus IFO3083 (MIC=0.46 ?M), Staphylococcus xylosus IAM1312 (MIC=0.27 ?M), Staphylococcus epidermidis IFO12993 (MIC=0.18 ?M), Streptococcus pyogenes ATCC21547 (MIC=0.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8530391##11997013 J Biol Chem. 1995 Dec 15;270(50):29923-29927.##FEBS Lett. 2002 May 8;518(1-3):33-38. "Hara S, Yamakawa M.##Hemmi H, Ishibashi J, Hara S, Yamakawa M." "Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori.##Solution structure of moricin, an antibacterial peptide, isolated from the silkworm Bombyx mori." DRAMP03567 KRIVQRIKDFLRNLVPRTES 20 KR-20 (Derived from LL-37) No entry found Not found Not found Homo sapiens (Human sweat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus mprF (MIC=16 ?M), Staphylococcus aureus ATCC 25923 (MIC>64 ?M), Staphylococcus aureus (GAS) (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC>64 ?M).##Yeast: Candida albicans ATCC 14053 (MIC=10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 14978112 J Immunol 2004; 172: 3070-3077. "Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL." Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. DRAMP03568 RKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 31 RK-31 (Derived from LL-37) No entry found Not found Not found Homo sapiens (Human sweat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Function: Has hemolytic activity against human erythrocytes . "[Ref.14978112]Gram-positive bacteria: Staphylococcus aureus mprF (MIC=8 ?M), Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Group A Staphylococcus aureus (GAS) (MIC=8 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC=8 ?M);##Yeast: Candida albicans ATCC 14053 (MIC=4 ?M)." [Ref.14978112]6% hemolytic activity at 44 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 14978112 J Immunol 2004; 172: 3070-3077. "Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL." Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. DRAMP03569 KSKEKIGKEFKRIVQRIKDFLRNLVPRTES 30 KS-30 (Derived from LL-37) No entry found Not found Not found Homo sapiens (Human sweat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Function:Has hemolytic activity against human erythrocytes. "[Ref.14978112]Gram-positive bacteria: Staphylococcus aureus mprF (MIC=8 ?M), Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Group A Staphylococcus aureus (GAS) (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC=8 ?M);##Yeast: Candida albicans ATCC 14053 (MIC=2 ?M)" [Ref.14978112]23% hemolytic activity at 88 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 14978112 J Immunol 2004; 172: 3070-3077. "Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL." Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. DRAMP03570 LLGDFFRKSKEKIGKEFKRIVQR 23 LL-23 (Derived from LL-37) "P49913, Q71SN9" Not found Not found Homo sapiens (Human sweat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 19 residues) "The Ser9 site splits the hydrophobic surface of the amphipathic helix into two domains, which explains its poor antimicrobial activity (active against only susceptible bacterial strains). " 2LMF resolved by NMR. "Its structure, dynamics, and antimicrobial and immune modulating activities have been characterized (Biochemistry 2012)." "Gram-negative bacterium: Escherichia coli DC2 (MIC=9 ?M);##Gram-positive bacteria: Staphylococcus aureus mprF (presence of carbonate) (MIC=3 ?M), S. aureu mprF (absence of carbonate) (MIC=24 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17012259##22185690 "FASEB J 2006; 20, 2068-2080.##Biochemistry. 2012 Jan 17;51(2):653-664. " "Yamasaki K et al. Gallo RL.##Wang G, Elliott M, Cogen AL, Ezell EL, Gallo RL, Hancock RE." "Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin.##Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins." DRAMP01877 GLMSVLKGVLKTAGKHIFKNVGGSLLDQAKCKITGQC 37 "Brevinin-2PRd (Frogs, amphibians, animals)" No entry found Not found Not found Rana pirica (Hokkaido frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: activity against reference strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae) and Gram-positive (Staphlococcus aureus) bacteria but displayed relatively low hemolytic activity. " "[Ref.15003829] Gram-negative bacterium: Escherichia coli(MIC=3M), Pseudemonas aeruginosa(MIC=3M), Enterobacter cloacae(MIC=6M), Klebsiella pneumoniae(MIC=6M);## Gram-positive bacterium: Staphylococcus aureus(MIC=25M);## Yeast: Candida albicans(MIC=100M)" [Ref.15003829] HC50=100 M against human erythrocytes Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 15003829 Regul Pept. 2004 May 15;118(3):135-141. "Conlon JM, Sonnevend A, Patel M, Al-Dhaheri K, Nielsen PF, Kolodziejek J, Nowotny N, Iwamuro S, P" "A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica." DRAMP01878 GLLSVLKGVLKTAGKHIFKNVGGSLLDQAKCKISGQC 37 "Brevinin-2PRe (Frogs, amphibians, animals)" No entry found Not found Not found Rana pirica (Hokkaido frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: activity against reference strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae) and Gram-positive (Staphlococcus aureus) bacteria but displayed relatively low hemolytic activity. " "[Ref.15003829] Gram-negative bacterium: Escherichia coli(MIC=3M), Pseudemonas aeruginosa(MIC=3M), Enterobacter cloacae(MIC=3M), Klebsiella pneumoniae(MIC=6M);## Gram-positive bacterium: Staphylococcus aureus(MIC=25M);## Yeast: Candida albicans(MIC>100M)" [Ref.15003829] HC50=80 M against human erythrocytes Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 15003829 Regul Pept. 2004 May 15;118(3):135-141. "Conlon JM, Sonnevend A, Patel M, Al-Dhaheri K, Nielsen PF, Kolodziejek J, Nowotny N, Iwamuro S, P" "A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica." DRAMP03573 IGKEFKRIVQRIKDFLRNLVPRTES 25 "LL-37(13-37)(C-terminal fragment of LL-37; Human, mammals, animals)" "P49913, Q71SN9" Not found Not found Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram-, Anticancer" Protein level Alpha helix (1 helices; 14 residues) Residues 17-29 of LL-37(13-37) are helical. 2FCG resolved by NMR. The slightly lower activity of LL-37(13-37) may result from the interference of the disordered regions with membrane binding of the peptide. "Gram-negative bacterium: Escherichia coli K12 (MIC=80 ?M).##Drug-resistant KBv cancer cells (LC50=39 ?M), Drug-sensitive KB cancer cells (LC50=40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16637646 J Am Chem Soc. 2006 May 3;128(17):5776-5785. "Li X, Li Y, Han H, Miller DW, Wang G. " Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. DRAMP03574 FKRIVQRIKDFLRNLV 16 "LL-37(17-32)(C-terminal fragment of LL-37; Human, mammals, animals)" "P49913, Q71SN9" Not found Not found Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram-, Anticancer" Protein level Not found "To achieve selective membrane targeting, D-amino acids were incorporated into LL-37(17-32). The D-peptide showed similar antibacterial activity to the L-diastereomer, it lost toxicity to human cells. " None Antibacterial and anticancer assays found that LL-37(17-32) was more active than LL-37(13-37). "Gram-negative bacteria: Escherichia coli K12(MIC=20 ?M).##Drug-resistant KBv cancer cells (LC50=30 ?M), Drug-sensitive KB cancer cells (LC50=30 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16637646 J Am Chem Soc. 2006 May 3;128(17):5776-5785. "Li X, Li Y, Han H, Miller DW, Wang G. " Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. DRAMP03598 GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP 41 "Human beta-defensin 2 (hBD-2; Defensin, beta 2; Beta-defensin 4A; Human, mammals, animals)" "O15263, Q52LC0" Belongs to the beta-defensin family DEFB4A AND DEFB4B Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Combine helix and strand structure The structure (one N-terminal helix and 3 beta strands) was found to be monomer in solution (PDB ID: 1E4Q) but a dimer in the crystal (PDB ID: 1FD3). "1FD4, 1FD3 resolved by X-ray.##1FQQ resolved by NMR." "Function: Has anti-HIV and antibacterial activity. Tissue specificity: Expressed in the skin and respiratory tract. Induction: By inflammation. PTM: Contains three disulfide bonds 8-37, 15-30, 20-38. Transgenic plants: expression of this peptide in Arabidopsis thaliana reduced fungal infection." "Gram-negative bacteria: Escherichia coli D31(MIC=62 ?g/ml), Escherichia coli ATCC (MIC=62 ?g/ml), Pseudomonas aeruginosa ATCC (MIC=62 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC (MIC=62 ?g/ml), Enterococcus faecalis ATCC (MIC=15 ?g/ml)." [Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 g/ml. Cyclic Free Free "Disulfide bonds between Cys8 and Cys37,Cys15 and Cys30,Cys20 and Cys38." L No cytotoxicity information found Not found 9202117##10906336##17340092 Nature. 1997 Jun 26;387(6636):861.##J Biol Chem. 2000 Oct 20;275(42):32911-32918.##Plant Cell Rep. 2007 Aug;26(8):1391-1398. "Harder J, Bartels J, Christophers E, Schr?der JM.##Hoover DM, Rajashankar KR, Blumenthal R, Puri A, Oppenheim JJ, Chertov O, Lubkowski J.##Aerts AM, Thevissen K, Bresseleers SM, Sels J, Wouters P, Cammue BP, Fran?ois IE." A peptide antibiotic from human skin.##The structure of human beta-defensin-2 shows evidence of higher order oligomerization.##Arabidopsis thaliana plants expressing human beta-defensin-2 are more resistant to fungal attack: functional homology between plant and human defensins. DRAMP03599 GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK 45 "Human beta-defensin 3 (BD-3, hBD-3; Hbd3; Beta-defensin 103; Human, mammals, animals)" "P81534, Q8NFG6, Q9NPF6" Belongs to the beta-defensin family DEFB103A AND DEFB103 Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Combine helix and strand structure Contains three disulfide bonds and a short helical segment preceding a three-stranded antiparallel beta-sheet. 1KJ6?resolved by NMR. "Function: Exhibits antimicrobial activity against Gram-positive bacteria and the Gram-negative bacteria and the yeast C.albicans. Kills multiresistant S. aureus and vancomycin-resistant E. faecium. Has hemolytic activity. Tissue specificity: Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. Induction: By bacterial infection and by IFNG/IFN-gamma. PTM: Contains three disulfide bonds 11-40; 18-33; 23-41." "[Ref.11085990]Gram-negative bacteria: Escherichia coli DSM1103 (MIC=9.4 ?g/ml), Klebsiella pneumoniae DSM681 (MIC=25 ?g/ml), Pseudomonas aeruginosa DSM1128 (MIC=18.75 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.7 ?g/ml), Streptococcus pneumoniae DSM11865 (MIC=4.7 ?g/ml)." "[Ref.11085990] It has 9% hemolysis at 250 ?g/ml, 15% hemolysis at 500 ?g/ml against human erythrocytes." Cyclic Free Free "Disulfide bonds between Cys11 and Cys40,Cys18 and Cys33,Cys23 and Cys41." L No cytotoxicity information found Not found 15625724##11085990 Biopolymers. 2005;80(1):34-49.##J Biol Chem. 2001 Feb 23;276(8):5707-5713. "Schulz A, Klver E, Schulz-Maronde S, Adermann K.##Harder J, Bartels J, Christophers E, Schroder JM." "Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins.##Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic." DRAMP03600 EFELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP 50 "Human beta-defensin 4 (hBD-4, BD-4; Beta-defensin 104; Human, mammals, animals)" "Q8WTQ1, Q496I2, Q496I3, Q496I4" Belongs to the beta-defensin family DEFB104A Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Bridge Not found None "Function: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. Tissue specificity: High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested. Induction: Antimicrobial activity is decreased when the sodium chloride concentration is increased. PTM: Contains three disulfide bonds (By similarity)." "Gram-positive bacterium: Staphylococcus carnosus TM300 (MIC=4.5 ?g/ml);##Gram-negative bacteria: Escherichia coli BL21 (MIC>100 ?g/ml), Pseudomonas aeruginosa (MIC=4.1 ?g/ml).##Yeast: Saccharomyces cerevisiae ATCC9763 (MIC>100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys8 and Cys36,Cys15 and Cys29,Cys19 and Cys37." L No cytotoxicity information found Not found 11481241 FASEB J. 2001 Aug;15(10):1819-1821. "Garca JR, Krause A, Schulz S, Rodrguez-Jimnez FJ, Klver E, Adermann K, Forssmann U, Frimpong-Boateng A, Bals R, Forssmann WG." Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. DRAMP03603 ARLKKCFNKVTGYCRKKCKVGERYEIGCLSGKLCCAN 37 "Human beta-defensin 28 (hBD-28; hBD28; Human, mammals, animals)" No entry found Belongs to the beta-defensin family Not found Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Bridge Not found None Function: Has antibacterial activity gaginst Gram-positive and the Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli DSM1103 (MIC=37.5 ?g/ml), Klebsiella pneumoniae DSM681 (MIC=50 ?g/ml), Pseudomonas aeruginosa DSM1128 (MIC=37.5 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=25 ?g/ml), Streptococcus pneumoniae DSM11865 (MIC=37.5 ?g/ml)." [Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 g/ml. Cyclic Free Free "Disulfide bonds between Cys6 and Cys34,Cys14 and Cys28,Cys18 and Cys35" L No cytotoxicity information found Not found 15625724 Biopolymers. 2005;80(1):34-49. "Schulz A, Klver E, Schulz-Maronde S, Adermann K." Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. DRAMP03638 LCLDQKPEMEPFRKDAQQALEPSRQRRWLHRRCLSGRGFCRAICSIFEEPVRGNIDCYFGYNCCRRMFSHYRTS 74 VpBD (V.philippinarum beta defensin; big defensin) No entry found Not found Not found Venerupis philippinarum (The manila clam) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: The rVpBD displays broad-spectrum inhibitory activity towards all tested bacteria with the highest activity against Staphyloccocus aureus and Pseudomonas putida. "Gram-positive bacteria: Staphyloccocus aureus (MIC=1.64-3.28 ?M), Micrococcus luteus (MIC>26.26 ?M), Bacillus sp. (MIC=13.13-26.26 ?M);##Gram-negative bacteria: Vibrio anguillarum (MIC=13.13-26.26 ?M), Entherobacter cloacae (MIC>26.26 ?M), Vibrio ichthyoenteri (MIC=3.28-6.56 ?M), Pseudomonas putida (MIC=1.64-3.28 ?M), Proteus mirabilis (MIC>26.26 ?M), Enterobacter sp. (MIC=13.13-26.26 ?M)" No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys33 and Cys63,Cys40 and Cys57,Cys44 and Cys64." L No cytotoxicity information found Not found 20975988 PLoS One. 2010 Oct 20;5(10):e13480. "Zhao J, Li C, Chen A, Li L, Su X, Li T." Molecular characterization of a novel big defensin from clam Venerupis philippinarum. DRAMP03642 GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIR 39 "Chicken heterophil peptides 1 (Antimicrobial peptide CHP1; Birds, animals)" P80389 Belongs to the beta-defensin family Not found Gallus gallus (Chicken) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Function: Bactericidal activity; inhibits S. aureus and E. coli. PTM: Contains three disulfide bonds 6-28; 13-34; 18-35." Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.7 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus (MIC=0.7 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys6 and Cys28,Cys13 and Cys34,Cys18 and Cys35." L No cytotoxicity information found Not found 7964174 J Leukoc Biol. 1994 Nov;56(5):661-665. "Evans EW, Beach GG, Wunderlich J, Harmon BG." Isolation of antimicrobial peptides from avian heterophils. DRAMP01376 GFMDTAKNAAKNVAVTLLDNLKCKITKAC 29 "Odorranain-F1 (OdF1; Frogs, amphibians, animals)" A6MBL3 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Odorranain-F1 adopts 55% None Function: Odorranain-F1 exhibites antimicrobial activities against the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbiit red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.20 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2.10 g/ml), Bacillus subtilis (MIC=8.40 g/ml).##Yeast: Candida albicans (MIC=1.05 g/ml)." "[Ref.17272268] RCH=15.4 3.5% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01378 GIFGKILGVGKKVLCGLSGVC 21 "Odorranain-H1 (OdH1; Frogs, amphibians, animals)" A6MBN4 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Odorranain-H1 adopts 50.3 -sheet structure in water solution. None Function: Odorranain-H1 exhibites antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbit red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=23.60 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=5.90 g/ml), Bacillus subtilis (MIC=5.90 g/ml).##Yeast: Candida albicans (MIC=11.80 g/ml)." "[Ref.17272268] RCH=21.6 7.3% against rabbit red blood cells. RCH, red cell hemolysis." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01386 VIPFVASVAAEMMQHVYCAASKKC 24 "Odorranain-P1a (OdP1a; Brevinin-1HS1; Brevinin-1-OA2; Frogs, amphibians, animals)" "A6MBQ8, A6MBQ6" Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Function: Odorranain-P1a exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbit red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.50 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.50 g/ml), Bacillus subtilis (MIC=1.75 g/ml).##Yeast: Candida albicans (MIC=1.75 g/ml)." "[Ref.17272268] RCH=11.2 2.9% against rabbit red blood cells. RCH, red cell hemolysis." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP03646 RVKRFWPLVPVAINTVAAGINLYKAIRRK 29 "Cathelicidin-3 (CATH-3; Fowlicidin-3; Birds, animals)" Q2IAL6 Not found CATHL3 Gallus gallus (Chicken) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix (1 helices; 9 residues) NMR spectroscopy reveales that fowlicidin-3 comprises 27 amino-acid residues and adopts a predominantly alpha-helical structure extending from residue 9 to 25 with a slight kink induced by a glycine at position 17.. 2HFR resolved by NMR. "Function: May have antimicrobial activity and play a role in the innate immune response. Tissue specificity: Detected in bone marrow, liver and lung." "Gram-negative bacteria: Escherichia coli 25922 (MIC=2 ?M), Salmonella typhimurium 14028 (MIC=2 ?M), S. typhimurium DT104 700408 (MIC=2 ?M), Salmonella enteritidis 13076 (MIC=2 ?M), Klebsiella pneumoniae 13883 (MIC=1 ?M);##Gram-positive bacteria: Listeria monocytogenes 19115 (MIC=2 ?M), Staphylococcus aureus 25923 (MIC=1 ?M), S. aureus (MRSA) 43300 (MIC=1 ?M), S. aureus (MRSA) BAA-39 (MIC=1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 17827276##16326712##17229147 Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15063-15068.##J Biol Chem. 2006 Feb 3;281(5):2858-2867.##FEBS J. 2007 Jan;274(2):418-428. "Goitsuka R, Chen CL, Benyon L, Asano Y, Kitamura D, Cooper MD.##Xiao Y, Cai Y, Bommineni YR, Fernando SC, Prakash O, Gilliland SE, Zhang G.##Bommineni YR, Dai H, Gong YX, Soulages JL, Fernando SC, Desilva U, Prakash O, Zhang G." "Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway.##Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity.##Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities." DRAMP03647 PIRNWWIRIWEWLNGIRKRLRQRSPFYVRGHLNVTSTPQP 40 "Cathelicidin-B1 (CATH-B1; cathelicidin; Birds, animals)" "Q5F378, A7M6V2" Not found CATHB1 Gallus gallus (Chicken) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=2.5 ?M), Pseudomonas aeruginosa (MIC=0.63 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=1.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17827276##15642098 Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15063-15068.##Genome Biol. 2005;6(1):R6. "Goitsuka R, Chen CL, Benyon L, Asano Y, Kitamura D, Cooper MD.##Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM." "Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway.##Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." DRAMP03659 LPRDTSRCVGYHGYCIRSKVCPKPFAAFGTCSWRQKTCCVDTTSDFHTCQDKGGHCVSPKIRCLEEQLGLCPLKRWTCCKEI 82 "Gallinacin-11 (Gal-11; Beta-defensin 11; Birds, animals)" "Q6IV20, A0A1W6, Q09MT4, Q9PS49" Belongs to the beta-defensin family GAL11 Gallus gallus (Chicken) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Bridge Not found None "Tissue specificity: Detected in outer membrane of the vitelline layer of the egg (at protein level). Expressed in the liver, gall bladder, kidney, testis, ovary and male and female reproductive tracts. Expressed in the ovarian stroma, but not in the ovarian follicles. No expression is detected in bone marrow. PTM: Contains three disulfide bonds 8-38; 15-31; 21-39." Gram-negative bacterium: Escherichia coli (MIC=50 nM). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17244739##1520265 Reproduction. 2007 Jan;133(1):127-133.##Biochem J. 1992 Aug 15;286 (Pt 1):17-22. "Subedi K, Isobe N, Nishibori M, Yoshimura Y.##Kido S, Morimoto A, Kim F, Doi Y." "Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus).##Isolation of a novel protein from the outer layer of the vitelline membrane." DRAMP03676 APRKNVRWCAISLPEWSKCYQWQRRMRKLGAPSITCIRRTS 41 GLFcin (Lactoferrin fragment) "Q29477, Q29479" Belongs to the transferrin family LTF Capra hircus (Goat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: GLFcin is thermal-stable and with high antibacterial activity. "Gram-negative bacteria: Escherichia coli (MIC=4.07 ?g/ml), Propioni bacterium acnes (MIC=12.32 ?g/ml), Pseudemonas aeruginosa (MIC=4.07 ?g/ml);##Gram-positive bacteria: Bacillus cereus (MIC=12.32 ?g/ml), Staphylococcus aureus (MIC=4.07 ?g/ml), Listeria monocytogene (MIC=4.07 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19780544 J Agric Food Chem. 2009 Oct 28;57(20):9509-9515. "Chen GH, Chen WM, Huang GT, Chen YW, Jiang ST." Expression of recombinant antibacterial lactoferricin-related peptides from Pichia pastoris expression system. DRAMP03677 SKCYQWQRRMRKLGAPSITCIRRTS 25 GLFcin II (Lactoferrin fragment) "Q29477, Q29479" Belongs to the transferrin family LTF Capra hircus (Goat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: GLFcin is thermal-stable and with high antibacterial activity. "Gram-negative bacteria: Escherichia coli (MIC=6.80 ?g/ml), Propioni bacterium acnes (MIC=10.50 ?g/ml), Pseudemonas aeruginosa (MIC=14.50 ?g/ml);##Gram-positive bacteria: Bacillus cereus (MIC=16.00 ?g/ml), Staphylococcus aureus (MIC=6.80 ?g/ml), Listeria monocytogene (MIC=9.92 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19780544 J Agric Food Chem. 2009 Oct 28;57(20):9509-9515. "Chen GH, Chen WM, Huang GT, Chen YW, Jiang ST." Expression of recombinant antibacterial lactoferricin-related peptides from Pichia pastoris expression system. DRAMP03679 RFRPPIRRPPIRPPFNPPFRPPVRPPFRPPFRPPFRPPIGPFP 43 "Cathelicidin-2 (Bactenecin-5, Bac5; ChBac5; ruminant, animals)" "P82018, Q4JFB9" Not found CATHL2 Capra hircus (Goat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=1 ?g/ml), Salmonella typhimurium (MIC=1 ?g/ml), Pseudomonas aeruginosa (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC<2 ?g/ml), Listeria monocytogenes (MIC<2 ?g/ml) and Bacillus subtilis (MIC<2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 10417180 nfect Immun. 1999 Aug;67(8):4106-4111. "Shamova O, Brogden KA, Zhao C, Nguyen T, Kokryakov VN, Lehrer RI." Purification and properties of proline-rich antimicrobial peptides from sheep and goat leukocytes. DRAMP03682 FLPIIAKLLGGLL 13 "Vespid chemotactic peptide 5e (VCP 5e; Insects, animals)" P0C1M1 Belongs to the MCD family (Crabrolin subfamily) Not found Vespa magnifica "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (By similarity)." [Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml). [Ref.16330062]Little hemolytic activity up to 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom. DRAMP03683 FLIIRRPIVLGLL 13 "Vespid chemotactic peptide 5g (VCP 5g; Insects, animals)" P0C1M3 Belongs to the MCD family (Crabrolin subfamily) Not found Vespa magnifica "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (By similarity)." [Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=10 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=12.5 ?g/ml). [Ref.16330062]Little hemolytic activity up to 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom. DRAMP03684 FLPIPRPILLGLL 13 "Vespid chemotactic peptide 5f (VCP 5f; Insects, animals)" P0C1M2 Belongs to the MCD family (Crabrolin subfamily) Not found Vespa magnifica "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (By similarity)." [Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml). [Ref.16330062]Little hemolytic activity up to 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom. DRAMP03687 FLSLIPSLVGGSISAFK 17 "TsAP-1 (T. serrulatus antimicrobial peptide 1; scorpions, arachnids, invertebrates, animals)" S6CWV8 Belongs to the?non-disulfide-bridged peptide (NDBP) superfamily.?Short antimicrobial peptide (group 4) family. Not found Tityus serrulatus (Brazilian yellow scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Anticancer activity against HI57 and H838." "[Ref.23770440] Gram-positive bacteria : Staphylococcus aureus(MIC=120 M, MBC>160 M);##Gram-negative bacteria : Escherichia coli(MIC=160 M, MBC>160 M);##Fungi : Candida albicans(MIC=160 M, MBC>160 M)" "[Ref.23770440] 0% hemolysis at 40 M , 2% hemolysis at 80 M , 5% hemolysis at 120 M , 7% hemolysis at 160 M against horse red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23770440 Biochimie. 2013 Jun 14. doi: 10.1016/j.biochi.2013.06.003. "Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C." "Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities." DRAMP03691 FSFKRLKGFAKKLWNSKLARKIRTKGLKYVKNFAKDMLSEGEEAPPAAEPPVEAPQ 56 "Im-1 (Arthropods, animals)" P0CF38 Belongs to the scorpion BPP family Not found Isometrus maculatus (Lesser brown scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Causes cytolysis by the formation of pores in the membrane. Causes rapid and reversible paralysis in crickets. Has antibacterial activity. Tissue specificity: Expressed by the venom gland. Toxic dose: PD50 is 38 mg/kg into the insect A. domestica." "Gram-negative bacterium: Escherichia coli NBRC 3972 (MIC=0.4-0.8 ?M);##Gram-positive bacteria: Staphylococcus aureus NBRC 13276 (MIC=13-25 ?M), Bacillus subtilis NBRC 3009 (MIC=0.8-1.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 20139620 Biosci Biotechnol Biochem. 2010;74(2):364-369. "Miyashita M, Sakai A, Matsushita N, Hanai Y, Nakagawa Y, Miyagawa H." A novel amphipathic linear peptide with both insect toxicity and antimicrobial activity from the venom of the scorpion Isometrus maculatus. DRAMP03693 KDGYIIEHRGCKYSCFFGTNSWCNTECTLKKGSSGYCAWPACWCYGLPDNVKIFDSNNLKC 61 "Bactridin-1 (Bact1; Bactridine 1; Arthropods, animals)" P0CF39 Belongs to the long (4 C-C) scorpion toxin superfamily Sodiu Not found Tityus discrepans (Venezuelan scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows antibacterial activity. Modifies membrane sodium permeability on Y.enterocolitica. Is toxic to cockroaches and crabs, but is not to mice. Does not induce haemolysis in human erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: Contains four disulfide bonds (By similarity) and C- terminal amidation." "Gram-positive bacteria: Bacillus subtillis ICTA-07 (MIC=22 ?M), Microccocus luteus ATCC 4698 (MIC=43 ?M), Enterococcus faecalis WHO14 (MIC=34 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=77 ?M), Yersinia enterocolitica ATCC 9610 (MIC=49 ?M), Acinetobacter calcoaceticus ATCC 2305-5 (MIC=43 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19540868##22355312 Toxicon. 2009 Nov;54(6):802-817.##PLoS One. 2012;7(2):e30478. "Daz P, D'Suze G, Salazar V, Sevcik C, Shannon JD, Sherman NE, Fox JW.##Guerrero-Vargas JA, Mour?o CB, Quintero-Hernndez V, Possani LD, Schwartz EF." Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes.##Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins. DRAMP03694 KDGYLVGNDGCKYSCFTRPGTYCANECSRVKGKDGYCYAWMACYCYSMPNWVKTWNRATNRCGR 64 "Bactridin-2 (Bact2, Bactridine 2; P-Mice-Antm-beta* NaTx14.8; Arthropods, animals)" P0CF37 Belongs to the long (4 C-C) scorpion toxin superfamily Sodiu Not found Tityus discrepans (Venezuelan scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-positive bacteria (B.subtilis, M.luteus, E.faecalis) and Gram-negative bacteria (P.aeruginosa, Y.enterocolitica, A.calcoaceticus). Modifies membrane sodium permeability on Y.enterocolitica. Is toxic to mice, but is not to crabs. Induces concentration dependent haemolysis in human erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: Contains four disulfide bonds (By similarity) and C-terminal amidation." "Gram-positive bacteria: Bacillus subtillis ICTA-07 (MIC=30 ?M), Microccocus luteus ATCC 4698 (MIC=27 ?M), Enterococcus faecalis WHO14 (MIC=65 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=54 ?M), Yersinia enterocolitica ATCC 9610 (MIC=46 ?M), Acinetobacter calcoaceticus ATCC 2305-5 (MIC=27 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19540868##22355312 Toxicon. 2009 Nov;54(6):802-817.##PLoS One. 2012;7(2):e30478. "Daz P, D'Suze G, Salazar V, Sevcik C, Shannon JD, Sherman NE, Fox JW.##Guerrero-Vargas JA, Mour?o CB, Quintero-Hernndez V, Possani LD, Schwartz EF." Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes.##Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins. DRAMP03702 LFGLIPSLIGGLVSAFK 17 "Mucroporin (Antimicrobial peptide 36.21; Arthropods, animals)" B9UIY3 Belongs to the short cationic antimicrobial peptide family Not found Lychas mucronatus (Chinese swimming scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Function: Cationic host defense peptide that have antibacterial activity by breaking membranes. Is more effective on Gram-positive than on Gram-negative bacteria. Its synthetic analog mucroporin-M1 is more effective. Tissue specificity: Expressed by the venom gland. Miscellaneous: Minimum inhibitory concentrations (MIC) for Mucroporin-1 analog are the following: MIC=12.5 ?g/ml against E.coli AB94012, MIC=100 ?g/ml against P.aeruginosa AB93066, MIC=25 ?g/ml against B.thuringiensis AB92037, MIC=25 ?g/ml against B.subtilis AB91021, MIC=5 ?g/ml against S.aureus AB94004, and MIC=5 ?g/ml against the methicillin-resistant coagulase-negative Staphylococcus. Furthermore, this analog is as effective against antibiotic-resistant pathogens as it is against antibiotic-sensitive pathogens." "Gram-negative bacteria: Escherichia coli AB94012 (MIC>100 ?g/ml), Pseudomonas aeruginosa AB93066 (MIC>100 ?g/ml);##Gram-positive bacteria: Bacillus thuringiensis AB92037 (MIC=25 ?g/ml), Bacillus subtilis AB91021 (MIC=50 ?g/ml), Staphylococcus aureus AB94004 (MIC=25 ?g/ml), Methicillin-resistant coagulase-negative S. aureus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 20663230##18779362 BMC Genomics. 2010 Jul 28;11:452.##Antimicrob Agents Chemother. 2008 Nov;52(11):3967-3972. "Ruiming Z, Yibao M, Yawen H, Zhiyong D, Yingliang W, Zhijian C, Wenxin L.##Dai C, Ma Y, Zhao Z, Zhao R, Wang Q, Wu Y, Cao Z, Li W." "Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components.##Mucroporin, the first cationic host defense peptide from the venom of Lychas mucronatus." DRAMP03706 FLFSLIPHAIGGLISAFK 18 "Antimicrobial peptide 1 (AamAP1; Arthropods, animals)" G8YYA5 Not found ap1 Androctonus amoreuxi (African fattail scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Causes hemolysis on horse erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: C-termianal amidation." Gram-positive bacterium: Staphylococcus aureus (MIC=20 ?M);##Gram-negative bacterium: Escherichia coli (MIC=150 ?M).##Yeast: Candida albicans (MIC=64 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 22484288 Peptides. 2012 Jun;35(2):291-299. "Almaaytah A, Zhou M, Wang L, Chen T, Walker B, Shaw C." "Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog." DRAMP03707 FPFSLIPHAIGGLISAIK 18 "Antimicrobial peptide 2 (AamAP2; Arthropods, animals)" G8YYA6 Not found ap2 Androctonus amoreuxi (African fattail scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Causes hemolysis on horse erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: C-termianal amidation." Gram-positive bacterium: Staphylococcus aureus (MIC=48 ?M);##Gram-negative bacterium: Escherichia coli (MIC=120 ?M).##Yeast: Candida albicans (MIC=64 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 22484288 Peptides. 2012 Jun;35(2):291-299. "Almaaytah A, Zhou M, Wang L, Chen T, Walker B, Shaw C." "Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog." DRAMP01392 GLLSGTSVRGSI 12 "Odorranain-V1 (OdV1; Frogs, amphibians, animals)" A6MBS7 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Function: Odorranain-V1 exhibites moderate antimicrobial activities against all of the tested microbes. Also has hemolytic activity against rabbit red cells "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=36.00 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=18.00 g/ml), Bacillus subtilis (MIC=18.00 g/ml).##Yeast: Candida albicans (MIC=9.00 g/ml)." "[Ref.17272268] RCH=23.9 4.7% against rabbit red blood cells. RCH, red cell hemolysis." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01393 GLFGKSSVWGRKYYVDLAGCAKA 23 "Odorranain-W1 (OdW1; Frogs, amphibians, animals)" A6MBS8 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Function: Odorranain-W1 has hemolytic activity against rabbit red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=12.60 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.30 g/ml), Bacillus subtilis (MIC=6.30 g/ml).##Yeast: Candida albicans (MIC=3.15 g/ml)." "[Ref.17272268] RCH=17.6 2.2% against rabbit red blood cells. RCH, red cell hemolysis." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP03715 FLSTLWNAAKSIF 13 "Amphiphatic peptide CT2 (VmCT2; Non-disulfide-bridged peptide 5.14, NDBP-5.14; Arthropods, animal" I0DEB4 Belongs to the scorpion NDBP 5 family Not found Vaejovis mexicanus smithi (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Amphipatic peptide that shows antibacterial activities against both Gram-positive and Gram-negative bacteria. Has hemolytic at its MIC range, but shows a strong cytotoxic activity at higher concentrations, reaching 84% lysis at 50 ?M. Tissue specificity: Expressed by the venom gland." "[Ref.22342498]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10 uM), Bacillus subtilis ATCC 6633 (MIC=20 ?M), Streptococcus agalactiae (clinical isolate) (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?M), Salmonella typhi ATCC 6399 (MIC=10 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=10 ?M)." "[Ref.22342498]25% hemolytic activity at 25 M, 84% hemolytic activity at 50 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 22342498 Peptides. 2012 Apr;34(2):290-295. "Ram??rez-Carreto S, Quintero-Hern??ndez V, Jim??nez-Vargas JM, Corzo G, Possani LD, Becerril B, Ortiz E." Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae. DRAMP01730 FLPLIGRVLSGIL 13 "Temporin-A (Frogs, amphibians, animals)" P56917 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found 2MAA resolved by NMR. "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has hemolytic activity. PTM: Leucine amide at position 13. Tissue specificity: Expressed by the skin glands." "[Ref.9022710] Gram-positive bacteria: Bacillus megaterium BM11 (LC=1.2 ?M), Staphylococcus aureus Cowan 1 (LC=2.3 ?M), Streptococcus pyogenes betahemolytic group A (LC=2.0 ?M);##Gram-negative bacteria: Escherichia coli D21 (LC=11.9 ?M), Escherichia coli D21e7 (LC=1.4 ?M), Escherichia coli D21f1 (LC=0.9 ?M), Escherichia coli D21f2 (LC=4.8 ?M), Escherichia coli D22 (LC=3.4 ?M), Yersinia pseudotuberculosis (LC=2.0 ?M), Pseudomonas aeruginosa ATCC 15692 (LC>360 ?M);##Yeast: Candida albicans ATCC 10261 (LC=3.4 ?M).(LC: Lethal concentration)" [Ref.9022710] LC>120 ?M against Human red blood cells. (LC: Lethal concentration) Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9022710 Eur J Biochem. 1996 Dec 15;242(3):788-792. "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D." "Temporins, antimicrobial peptides from the European red frog Rana temporaria." DRAMP03723 GKVWDWIKSAAKKIWSSEPVSQLKGQVLNAAKNYVAEKIGATPT 44 "Pandinin-1 (Pin1; Arthropods, animals)" P83239 Belongs to the Scorpion family Not found Pandinus imperator (Emperor scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None MOA: Disrupts cell membranes through formation of pores. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC>20.8 ?M), Escherichia coli (MIC=20.8 ?M);##Gram-positive bacteria: Enterococcus faecalis (MIC=1.3 ?M), Bacillus subtilis (MIC=5.2 ?M), Staphylococcus epidermidis (MIC=5.2 ?M), Staphylococcus aureus (MIC=2.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11563967##16199510 Biochem J. 2001 Oct 1;359(Pt 1):35-45.##Biophys J. 2005 Dec;89(6):4067-4080. "Corzo G, Escoubas P, Villegas E, Barnham KJ, He W, Norton RS, Nakajima T.##Nomura K, Ferrat G, Nakajima T, Darbon H, Iwashita T, Corzo G." Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.##Induction of morphological changes in model lipid membranes and the mechanism of membrane disruption by a large scorpion-derived pore-forming peptide. DRAMP03724 FWGALAKGALKLIPSLFSSFSKKD 24 "Pandinin-2 (Pin2; Arthropods, animals)" P83240 Belongs to the scorpion NDBP 4 family Not found Pandinus imperator (Emperor scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Hemolytic" Protein level Alpha helix Not found None "Function: Disrupts cell membranes through formation of pores. Has strong antimicrobial activity against Gram-positive bacteria and less active against Gram-negative bacteria. Possesses antifungal activity against C. albicans and hemolytic activity against sheep and pig erythrocytes. Tissue specificity: Expressed by the venom gland." "[Ref.11563967]Gram-negative bacteria: Pseudomonas aeruginosa (MIC=38.2 ?M), Escherichia coli (MIC=19.1 ?M);#Gram-positive bacteria: Enterococcus faecalis (MIC=2.4 ?M), Bacillus subtilis (MIC=4.8 ?M), Staphylococcus epidermidis (MIC=4.8 ?M), Staphylococcus aureus (MIC=2.4 ?M);##Yeast: Candida albicans (MIC=19.1 ?M)." [Ref.11563967]Strong hemolytic activity (11.1-44.5 microM) against sheep erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11563967##15328050##15298871 Biochem J. 2001 Oct 1;359(Pt 1):35-45.##Biochim Biophys Acta. 2004 Aug 30;1664(2):182-188.##Biophys J. 2004 Oct;87(4):2497-507. "Corzo G, Escoubas P, Villegas E, Barnham KJ, He W, Norton RS, Nakajima T.##Belokoneva OS, Satake H, Mal'tseva EL, Pal'mina NP, Villegas E, Nakajima T, Corzo G.##Nomura K, Corzo G, Nakajima T, Iwashita T." Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.##Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size.##Orientation and pore-forming mechanism of a scorpion pore-forming peptide bound to magnetically oriented lipid bilayers. DRAMP03729 KWFNEKSIQNKIDEKIGKNFLGGMAKAVVHKLAKNEFMCVANVDMTKSCDTHCQKASGEKGYCHGTKCKCGVPLSY 76 "Opiscorpine-1 (Arthropods, animals)" "Q5WR03, Q5WQZ8" Belongs to the long chain scorpion toxin family (Class 3 subfamily) Not found Opistophthalmus carinatus (African yellow leg scorpion) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: The short amino-terminal segment of opiscorpine 1 (residues 1C35), named Jan-f3, has antimicrobial activity against fungi and the Gram-negative bacteria. Tissue specificity: Expressed by the venom gland. PTM: Contains three disulfide bonds (By similarity)." "Fungi: Fusarium culmorum IMI180420 (IC50=8.8 ?M), Fusarium oxysporum MUCL39789 (IC50=10.04 ?M).##Gram-negative bacterium: Escherichia coli JM109 (MIC=12 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15241551 Cell Mol Life Sci. 2004 Jul;61(14):1751-1763. "Zhu S, Tytgat J." "The scorpine family of defensins: gene structure, alternative polyadenylation and fold recognition." DRAMP03734 FKLGSFLKKAWKSKLAKKLRAKGKEMLKDYAKGLLEGGSEEVPGQ 45 "Parabutoporin (PP; Non-disulfide-bridged peptide 3.2, NDBP-3.2; Arthropods, animals)" P83312 Belongs to the scorpion BPP family Not found Parabuthus schlechteri (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity. Induces reversible G-protein dependent Ca2+ release from intracellular stores and increase Ca2+ influx in HL-60 cells. Induces the activation of the Rac pathway in granulocytes. Synergistically enhances the excitatory effects of short and long chain ion-channel-specific neurotoxins by interaction with the neuronal membranes. Tissue specificity: Expressed by the venom gland. NOTE: residue 11, 44, 55 are uncertainty." "[Ref.12354111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.1 ?M), Escherichia coli DH5a (MIC=3.1 ?M), Pseudomonas aeruginosa ATCC 257853 (MIC=6.3 ?M), Klebsiella pneumoniae ATCC 13833 (MIC=1.6 ?M), Salmonella choleraesuis ATCC 13311 (MIC=3.1 ?M), Haemophilus influenzae ATCC 19418 (MIC=3.1 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=6.3 ?M), Listeria monocytogenes NCTC 11994 (MIC=6.3 ?M), Micrococcus luteus ATCC 9341 (MIC=25 ?M);##Fungi: Neurospora crassa (MIC=2.5 ?M), Botrytis cinerea (MIC=3.5 ?M), Fusarium culmorum (MIC=0.3 ?M), Saccharomyces cerevisiae (MIC=2 ?M)." [Ref.12354111]50% hemolysis is induced by about 38 ?M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12354111##12457879##14575699##15245865 Eur J Biochem. 2002 Oct;269(19):4799-4810.##Toxicon. 2002 Dec;40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7;311(1):90-97.##Peptides. 2004 Jul;25(7):1079-1084. "Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, Thevissen K, Tytgat J, Van Eldere J, Van Der Walt J, Verdonck F.Willems J, Noppe W, Moerman L, van der Walt J, Verdonck F.##Moerman L, Verdonck F, Willems J, Tytgat J, Bosteels S.##Willems J, Moerman L, Bosteels S, Bruyneel E, Ryniers F, Verdonck F." "Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.##Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes.##Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells.##Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions." DRAMP03735 GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS 44 "Opistoporin-1 (OP1; Non-disulfide-bridged peptide 3.5; Opistoporin-3, OP3; Arthropods, animals)" "P83313, Q5VJS8, Q5VJT0" Belongs to the antimicrobial peptide scorpion family Not found Opistophthalmus carinatus (African yellow leg scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity. Tissue specificity: Expressed by the venom gland." "[Ref.12354111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 ?M), Escherichia coli DH5a (MIC=6.3 ?M), Serratia marcescens ATCC 133880 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 257853 (MIC=12.5 ?M), Klebsiella pneumoniae ATCC 13833 (MIC=6.3 ?M), Salmonella choleraesuis ATCC 13311 (MIC=25 ?M), Haemophilus influenzae ATCC 19418 (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=12.5 ?M), Bacillus subtilis IP 5832 (MIC=12.5 ?M), Listeria monocytogenes NCTC 11994 (MIC=12.5 ?M), Micrococcus luteus ATCC 9341 (MIC>50 ?M), Enterococcus faecalis ATCC 19433 (MIC=12.5 ?M), Staphylococcus aureus ATCC 292136.3 (MIC>50 ?M), Streptococcus pneumoniae ATCC 33400 (MIC=12.5 ?M), Nocardia asteroides ATCC 3308 (MIC>50 ?M);##Fungi: Neurospora crassa (IC50=0.8 ?M), Botrytis cinerea (IC50=3.1 ?M), Fusarium culmorum (IC50=0.8 ?M), Saccharomyces cerevisiae (IC50=2 ?M)." "[Ref.12354111]10% hemolytic activity at 10 ?M, 30% hemolytic activity at 100 ?M against human red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12354111##12457879##14575699 Eur J Biochem. 2002 Oct;269(19):4799-4810.##Toxicon. 2002 Dec;40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7;311(1):90-97. "Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, Thevissen K, Tytgat J, Van Eldere J, Van Der Walt J, Verdonck F.Willems J, Noppe W, Moerman L, van der Walt J, Verdonck F.##Moerman L, Verdonck F, Willems J, Tytgat J, Bosteels S." "Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.##Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes.##Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells." DRAMP03738 GWINEEKIQKKIDERMGNTVLGGMAKAIVHKMAKNEFQCMANMDMLGNCEKHCQTSGEKGYCHGTKCKCGTPLSY 75 "Scorpine (defensins; Arthropods, animals)" P56972 Belongs to the long chain scorpion toxin family (Class 3 subfamily) Not found Pandinus imperator (Emperor scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Has antibacterial activity and a potent inhibitory effect on the ookinete (ED(50) 0.7 uM) and gamete (ED(50) 10 uM) stages of Plasmodium berghei development. Gram-positive bacterium: Bacillus subtilis (MIC=1.0 ?M);##Gram-negative bacterium: Klebsiella pneumoniae (MIC=10 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10767415 FEBS Lett. 2000 Apr 14;471(2-3):165-168. "Conde R, Zamudio FZ, Rodr??guez MH, Possani LD." "Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom." DRAMP02828 GLFRRLRDSIRRGQQKILEKARRIGERIKDIFRG 34 "BMAP-34 (BMAP 34, bovine cathelicidin, cattle, ruminant, mammals, animals)" P56425 Belongs to the cathelicidin family. CATHL7 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Tissue specificity: Expressed in bone marrow myeloid cells, spleen and testis." "[Ref.9795251] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3 M), Staphylococcus aureus Cowan 1 (MIC=3 M), Staphylococcus aureus (MRSA, clinical isolate) (MIC=6 M), Staphylococcus epidermidis ATCC 12228 (MIC=1.5 M), Bacillus megaterium Bm 11 (MIC=3 M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1.5 M), Escherichia coli ML-35 (MIC=1.5 M), Escherichia coli D21 (MIC=1.5 M), Escherichia coli D22 (MIC=1.5 M), Salmonella typhimurium ATCC 14028 (MIC=3 M), Salmonella enteritidis (clinical isolate) (MIC=3 M), Serratia marcescens ATCC 8100 (MIC=1.5 M), Pseudomonas aeruginosa ATCC 27853 (MIC48 M);##Fungus: Candida albicans (clinical isolate) (MIC>96 M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9409740##9795251 FEBS Lett. 1997 Nov 17;417(3):311-5.##Biochim Biophys Acta. 1998 Oct 23;1425(2):361-368. "Scocchi M, Wang S, Zanetti M.##Gennaro R, Scocchi M, Merluzzi L, Zanetti M." Structural organization of the bovine cathelicidin gene family and identification of a novel member.##Biological characterization of a novel mammalian antimicrobial peptide. DRAMP02926 KWCFRVCYRGICYRRCR 17 "Tachyplesin I (Tac; TP1; Horseshoe Crab, arachnids, Chelicerata, arthropods, invertebrates, animals)" P14213 Belongs to the tachyplesin/polyphemusin family. Not found Tachypleus tridentatus (Japanese horseshoe crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Anti-HIV, Anti-cancer" Protein level Beta strand This stability is due to the rigid structure imposed by the two disulfide linkages. Its amphipathic nature is closely associated with biological activity. A "1MA2, 1MA5, 6PIN, 1WO0, 1WO1, 2MDB, 2RTV resolved by NMR." "Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria, also anti-HIV activity may be due to the inhibition of virual adsorption to cells. PTM: Contains two disulfide bonds 3-16; 7-12 and Arginine amide at R17." No MICs found in DRAMP database [Ref.29870123] 9.6% hemolytic activity at 8 g/mL and 72.8% hemolytic activity at 512 g/mL against human red blood cells. Cyclic Free Amidation (Arg17) "Disulfide bond between Cys3 and Cys16,Cys7 and Cys12." L "[Ref.28429216]It possessed a cytotoxic effect on HL-60 cells (acutehuman promyelocytic leukemia cells) , K562 cells(myelogenous leukemia cells) , TSU cells (prostatecancer cells) ." Cell membrane 12369825##2229025 Biochemistry 2002; 41: 12359.##J Biochem. 1990 Aug;108(2):261-266. "Laederach A, Andreotti AH, Fulton, DB.##Muta T, Fujimoto T, Nakajima H, Iwanaga S." "Solution and Micelle-Bound Structures of Tachyplesin I and its Active Aromatic Linear Derivatives.##Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor." DRAMP03746 FIGAIARLLSKIF 13 "Peptide BmKn2 (Biologically active peptide 4; NDBP-5.1; Arthropods, animals)" Q6JQN2 Not found Kn2 Mesobuthus martensii (Buthus martensii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus (MIC=0.6 ?g/ml), Micrococcus luteus(MIC=8 ?g/ml), Bacillus subtilis (MIC=5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=1.5 ?g/ml), Pseudomonas aeruginosa (MIC=21.3 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15062994 Peptides. 2004 Feb;25(2):143-150. "Zeng XC, Wang SX, Zhu Y, Zhu SY, Li WX." Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch. DRAMP03748 FRFGSFLKKVWKSKLAKKLRSKGKQLLKDYANKVLNGPEEEAAAPAE 47 "Bradykinin-potentiating peptide BmK3 (Bpp BmK3; NDBP-3.3; Arthropods, animals)" Q9Y0X4 Belongs to the scorpion BPP family Not found Mesobuthus martensii (Manchurian scorpion) (Buthus martensii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix (predict) "The secondary structure prediction for BmKbpp reveals that BmKbpp is composed of an -helical structure from amino residues 3-35, followed by a coil-coiled region of three residues (NGP), and ended with an -helical region of 9 residues (ref.2)." None "Function: Amphipathic peptide that shows bradykinin potentiating activity and antimicrobial activities against bacteria and fungi. Has higher antibacterial activities against Gram-negative than against Gram-positive bacteria. Also inhibits NADPH oxidase-dependent superoxide production (IC50 is 0.4 ?M on granulocytes stimulated with PMA, IC50 is 0.51 ?M on HL-60 cells undifferentiated and IC50 is 0.53 ?M on HL-60 cells treated with DMSO). The C-terminal peptide shows a higher bradykinin potentiating activity than the complete peptide. Tissue specificity: Expressed by the venom gland. Miscellaneous: Shows hemolytic activity. Shows a alpha-helical structure. The genomic DNA coding for this protein is not a continuous sequence in the genome. The transcript of this protein may be generated by trans-splicing, by which exons from two independently transcribed pre-mRNAs are joined to form a single mature transcript." "[Ref.22115565]Gram-negative bacteria: Escherichia coli DH 5- (MIC=2.3 ?M), Haemophilus in?uenzae ATCC 31517 (MIC=3.2 ?M), Klebsiella pneumoniae ATCC 13882 (MIC=2.8 ?M), Salmonella enterica ATCC 8090 (MIC=2.3 ?M), Pseudomonas aeruginosa ATCC 9229 (MIC=4.7 ?M), Serratia marcescens ATCC 13880 (MIC=68.2 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=24.4 ?M), Listeria monocytogenes ATCC 35152 (MIC=5.7 ?M), Micrococcus luteus ATCC 9341 (MIC=20.3 ?M), Enterococcus faecalis ATCC 14508 (MIC=57.1 ?M), Nocardia asteroides ATCC 3308 (MIC>70 ?M), Staphylococcus aureus ATCC 14458 (MIC>70 ?M);##Fungi: Neurospora crassa FGSC 2489 (IC50=2 ?M), Botrytis cinerea ATCC 28387 (IC50=3.1 ?M), Fusarium culmorum ATCC 32973 (IC50=0.2 ?M)." "[Ref.22115565]3.5% hemolytic activity at 6 M, 11.2% hemolytic activity at 10 M, 22.5% hemolytic activity at 30 M, 33.9% hemolytic activity at 50 M against human red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10868911##22115565 IUBMB Life. 2000 Mar;49(3):207-210.##Peptides. 2012 Jan;33(1):44-51. "Zeng XC, Li WX, Peng F, Zhu ZH.##Zeng XC, Wang S, Nie Y, Zhang L, Luo X." "Cloning and characterization of a novel cDNA sequence encoding the precursor of a novel venom peptide (BmKbpp) related to a bradykinin-potentiating peptide from Chinese scorpion Buthus martensii Karsch.##Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides." DRAMP03750 IFGAIAGLLKNIF 13 "Venom antimicrobial peptide-6 (Meucin-13; NDBP-5; Arthropods, animals)" "E4VP07, E4VP35" Belongs to the scorpion NDBP 5 family Not found Mesobuthus eupeus (Lesser Asian scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Amphipathic peptide that exhibits extensive cytolytic activities against both prokaryotic and eukaryotic cells. Is more potent against Gram-positive bacteria (lethal concentration (LC=0.25-2.9 ?M) than against Gram-negative bacteria (LC=6.2->50 ?M), and fungi (LC=14.1->50 ?M). Shows hemolytic activity against rabbit erythrocytes and cytolysis against rat dorsal root ganglions. In vivo, intravenous injection into mice tail provokes uncomfortable symptoms with a death rate of 12.5%. Tissue specificity: Expressed by the venom gland." "[Ref.19088182]Gram-positive bacteria: Bacillus sp. DM-1 (MIC=2 ?M), Micrococcus luteus (MIC=2.9 ?M), Bacillus megaterium (MIC=0.25 ?M);##Gram-negative bacteria: Agrobacterium tumefaciens (MIC=11.8 ?M), Escherichia coli (MIC=7.90 ?M), Shewanella oneidensis (MIC=6.20 ?M), Stenotrophomonus sp. YC-1 (MIC=6.20 ?M);##Fungi: Beauveria spp. (MIC=14.1 ?M), Neurospora crassa (MIC=18.3 ?M), Candida albicans (MIC=42.8 ?M), Saccharomyces cerevisiae (MIC=18.3 ?M)." "[Ref.19088182]37.7% hemolytic activity at 6.25 M, 59.2% hemolytic activity at 12.5 M against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 19088182 FASEB J. 2009 Apr;23(4):1230-1245. "Gao B, Sherman P, Luo L, Bowie J, Zhu S." Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. DRAMP03751 FFGHLFKLATKIIPSLFQ 18 "Venom antimicrobial peptide-9 (Meucin-18; NDBP-5; Arthropods, animals)" E4VP50 Belongs to the ponericin-W family Not found Mesobuthus eupeus (Lesser Asian scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Amphipathic peptide that exhibits extensive cytolytic activities against both prokaryotic and eukaryotic cells. Is more potent against Gram-positive bacteria (lethal concentration (LC=1.5-10.9 ?M) than against Gram-negative bacteria (LC=6.2-50 ?M), and fungi (LC=25.1-8.3 ?M). Is lethal to the fungus Beauveria sp (LC=1.9 ?M), a highly lethal pathogenic fungus to insects and resistant to many AMPs. Shows hemolytic activity against rabbit erythrocytes and cytolysis against rat dorsal root ganglions. In vivo, intravenous injection into mice tail provokes uncomfortable symptoms with a death rate of 12.5%. Tissue specificity: Expressed by the venom gland." "[Ref.19088182]Gram-positive bacteria: Bacillus sp. DM-1 (MIC=0.60 ?M), Micrococcus luteus (MIC=0.60 ?M), Bacillus megaterium (MIC=0.25 ?M);##Gram-negative bacteria: Agrobacterium tumefaciens (MIC=6.00 ?M), Escherichia coli (MIC=2.40 ?M), Shewanella oneidensis (MIC=1.50 ?M), Stenotrophomonus sp. YC-1(MIC=2.60 ?M), Salmonella typhimurium (MIC=10.9 ?M);##Fungi: Beauveria spp.(MIC=1.9 ?M), Neurospora crassa (MIC=5.2 ?M), Candida albicans (MIC=25.1 ?M), Saccharomyces cerevisiae (MIC=25.1 ?M), Aspergillus fumigatus (MIC=8.3 ?M), Geotrichum candidum (MIC=3.5 ?M)." "[Ref.19088182]74% hemolytic activity at 6.25 M, 100% hemolytic activity at 12.5 M against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 19088182 FASEB J. 2009 Apr;23(4):1230-1245. "Gao B, Sherman P, Luo L, Bowie J, Zhu S." Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. DRAMP03752 FLFSLIPSAISGLISAFK 18 "Peptide BmKb1 (Non-disulfide-bridged peptide 4.2, NDBP-4.2; Arthropods, animals)" "Q718F4, Q2M5D6 Q95P85" Not found Kb1 Mesobuthus martensii (Manchurian scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Micrococcus luteus(MIC=81.5 ?g/ml), Bacillus subtilis (MIC=48.8 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=18.1 ?g/ml), Pseudomonas aeruginosa (MIC=90.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Forms a helical membrane channel in the prey) 15062994##16040157 Peptides. 2004 Feb;25(2):143-150.##Peptides. 2005 Dec;26(12):2427-2433. "Zeng XC, Wang SX, Zhu Y, Zhu SY, Li WX.##Luo F, Zeng XC, Hahin R, Cao ZJ, Liu H, Li WX." Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch.##Genomic organization of four novel nondisulfide-bridged peptides from scorpion Mesobuthus martensii Karsch: gaining insight into evolutionary mechanism. DRAMP03753 GFWGSLWEGVKSVV 14 "Amphipathic peptide CT1 (StCT1; Non-disulfide-bridged peptide 5, NDBP-5; Arthropods, animals)" P0DJO3 Not found Not found Scorpiops tibetanus (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide that is rapidly bactericidal against Gram-positive bacteria (MIC=12.5 ?g/ml against S.aureus, and MIC=100 ?g/ml against M. luteus). Is also active against clinical antibiotics-resistant bacterial strains. PTM: C-terminal amidation and Cleavage on pair of basic residues. Miscellaneous: Is highly capable of inhibiting antibiotic-resistant pathogen growth, including methicillin-resistant S.aureus. In vivo, shows high antimicrobial activity on a S.aureus-infected mouse model." "Gram-positive bacteria: Staphylococcus aureus AB94004 (MIC=12.5 ?g/ml), Bacillus thuringensis AB92037 (MIC>100 ?g/ml), Bacillus subtilis AB91021 (MIC>100 ?g/ml), Micrococcus luteus AB93113 (MIC=100 ?g/ml), MRSA P1374 (MIC=200 ?g/ml), MRSA P1386 (MIC=250 ?g/ml);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=100 ?g/ml), Pseudomonas aeruginosa AB93066 (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 19854232 Peptides. 2010 Jan;31(1):22-26. "Yuan W, Cao L, Ma Y, Mao P, Wang W, Zhao R, Wu Y, Cao Z, Li W." Cloning and functional characterization of a new antimicrobial peptide gene StCT1 from the venom of the scorpion Scorpiops tibetanus. DRAMP03754 GFWGKLWEGVKSAI 14 "Amphipathic peptide CT2 (StCT2; Non-disulfide-bridged peptide 5, NDBP-5; Arthropods, animals)" P0DJO4 Not found Not found Scorpiops tibetanus (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "PTM: C-terminal amidation and Cleavage on pair of basic residues. Miscellaneous: Is highly capable of inhibiting antibiotic-resistant pathogen growth, including methicillin-resistant S.aureus. In vivo, shows high antimicrobial activity on a S.aureus-infected mouse model." "Gram-positive bacteria: Staphylococcus aureus AB94004 (MIC=6.25 ?g/ml), Bacillus thuringensis AB92037 (MIC=50 ?g/ml), Bacillus subtilis AB91021 (MIC=25 ?g/ml), Micrococcus luteus AB93113 (MIC=25 ?g/ml), PRSA P1383 (MIC=12.5 ?g/ml), PRSE P1389 (MIC=12.5 ?g/ml), MRCNS P1369 (MIC=6.25 ?g/ml), MRSA P1374 (MIC=6.25 ?g/ml), MRSA P1386 (MIC=12.5 ?g/ml), MRSA P1381 (MIC=25 ?g/ml), MSSE P1111 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=50 ?g/ml), Pseudomonas aeruginosa AB93066 (MIC>100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 22542475 Peptides. 2012 Aug;36(2):213-220. "Cao L, Li Z, Zhang R, Wu Y, Li W, Cao Z." "StCT2, a new antibacterial peptide characterized from the venom of the scorpion Scorpiops tibetanus." DRAMP03774 GFWGKLWEGVKNAI 14 "UyCT1 (Arthropods, animals)" No entry found Not found Not found Urodacus yaschenkoi (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity. "[Ref.23182832]Gram-positive bacterium: Staphylococcus aureus ATCC 25953 (MIC=15 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=10 ?M)." "[Ref.23182832]20% hemolytic activity at 12.5 M, 45% hemolytic activity at 25 M, 80% hemolytic activity at 50 M, 90% hemolytic activity at 100 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23182832 Toxicon. 2013 Mar 1;63:44-54. "Luna-Ramrez K, Quintero-Hernndez V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD." "Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity." DRAMP03775 FWGKLWEGVKNAI 13 "UyCT2 (Arthropods, animals)" No entry found Not found Not found Urodacus yaschenkoi (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity. "[Ref.23182832]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=40 ?M)." "[Ref.23182832]3% hemolytic activity at 12.5 M, 6% hemolytic activity at 25 M, 5% hemolytic activity at 50 M, 35% hemolytic activity at 100 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23182832 Toxicon. 2013 Mar 1;63:44-54. "Luna-Ramrez K, Quintero-Hernndez V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD." "Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity." DRAMP03776 ILSAIWSGIKSLF 13 "UyCT3 (Arthropods, animals)" No entry found Not found Not found Urodacus yaschenkoi (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity. "[Ref.23182832]Gram-positive bacterium: Staphylococcus aureus ATCC 25953 (MIC=10 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=6 ?M)." "[Ref.23182832]30% hemolytic activity at 12.5 M, 90% hemolytic activity at 25 M, 92% hemolytic activity at 50 M, 90% hemolytic activity at 100 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23182832 Toxicon. 2013 Mar 1;63:44-54. "Luna-Ramrez K, Quintero-Hernndez V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD." "Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity." DRAMP03777 IWSAIWSGIKGLL 13 "UyCT5 (Arthropods, animals)" No entry found Not found Not found Urodacus yaschenkoi (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity. "[Ref.23182832]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=2 ?M).##Gram-positive bacterium: Staphylococcus aureus ATCC 25953 (MIC=1 ?M)." "[Ref.23182832]27% hemolytic activity at 12.5 M, 65% hemolytic activity at 25 M, 95% hemolytic activity at 50 M, 90% hemolytic activity at 100 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23182832 Toxicon. 2013 Mar 1;63:44-54. "Luna-Ramrez K, Quintero-Hernndez V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD." "Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity." DRAMP03814 GILDTLKQFAKGVGKWLVKGAAQGVLSTVSCKLAKTC 37 D16W (GGN4 analogue peptide with single substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Alpha helix Not found None Function: Single substitution of aspartic acid 16 by tryptophan (D16W) in the native GGN4. Has hemolytic activity as well as the antimicrobial activity. "[Ref.12199716]Gram-positive bacteria: Micrococcus luteus (MIC=25 ?g/ml), Bacillus subtilis (MIC=2.5 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=10 ?g/ml), Shigella dysentariae (MIC=10 ?g/ml), Pseudomonas putida (MIC=100 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=10 ?g/ml), Salmonella typhimurium (MIC=50 ?g/ml)." "[Ref.12199716] 1.97% hemolytic activity at 10 ?g/mL, 52.9% hemolytic activity at 100 ?g/mL against human red blood cells." Cyclic Free Cyclization(Cys31 and Cys37). Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 12199716 Eur J Biochem. 2002 Sep;269(17):4367-4374. "Won HS, Park SH, Kim HE, Hyun B, Kim M, Lee BJ, Lee BJ." Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4. DRAMP03815 GILDTLKQFAKGVGKWLVKGAAQ 23 D16W-N23 (single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None "Comment: Single substitution of aspartic acid 16 by tryptophan (D16W) in the Delta24-37 GGN4, which is a peptide analogue with 14 residues truncated from the C-terminus of GGN4." "Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Bacillus subtilis (MIC=25 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=125 ?g/ml), Eshchericia coli (MIC=25 ?g/ml), Salmonella typhimurium (MIC=125 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12199716 Eur J Biochem. 2002 Sep;269(17):4367-4374. "Won HS, Park SH, Kim HE, Hyun B, Kim M, Lee BJ, Lee BJ." Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4. DRAMP03816 GILDTLKQFAKGVGKFLVKGAAQ 23 D16F-N23 (single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None "Comment: Single substitution of aspartic acid 16 by phenylalanine (D16F) in the Delta24-37 GGN4, which is a peptide analogue with 14 residues truncated from the C-terminus of GGN4." "Gram-positive bacterium: Bacillus subtilis (MIC=25 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=100 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=200 ?g/ml), Eshchericia coli (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12199716 Eur J Biochem. 2002 Sep;269(17):4367-4374. "Won HS, Park SH, Kim HE, Hyun B, Kim M, Lee BJ, Lee BJ." Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4. DRAMP03823 ALWKTLLKKVLKA 13 Dermaseptin derivative K4-S4-(1-13) P80280 Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Alpha helix (1 helices; 5 residues) "The Ramachandran plot of P showes that residues 2 and 4-13 are all in -helix regions of the plot; the residues in all of the structures are in the core -helix region for residues 2, 3, and 6-11, and both residue 5 and 12 had over 60% in the core and the rest in allowed -helix regions." 2DD6 resolved by NMR. Function: Has antibacterial activity. Also has hemolytic activity against red blood cells (RBCs). [Ref.15917541]Gram-negative bacterium: Escherichia coli U16318 (MIC=9-3 ?M);##Gram-positive bacterium: Staphylococcus aureus B38302 (MIC=4.5-1.5 ?M). [Ref.15917541]LC50=50 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 16407175##15917541 J Biol Chem. 2006 Apr 7;281(14):9432-9438.##Antimicrob Agents Chemother. 2005 Jun;49(6):2412-2420. "Shalev DE, Rotem S, Fish A, Mor A.##Radzishevsky IS, Rotem S, Zaknoon F, Gaidukov L, Dagan A, Mor A." Consequences of N-acylation on structure and membrane binding properties of dermaseptin derivative K4-S4-(1-13).##Effects of acyl versus aminoacyl conjugation on the properties of antimicrobial peptides. DRAMP03824 FKCRRWQWR 9 CNBr-cleaved lactoferricin Subfragment 1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None "Function: The antibacterial activity of this subfragment 1 is not as potent as that of intact lactoferricin, having an MIC of 10 to 50 ?M for most of the bacteria tested." "Gram-negative bacteria: Escherichia coli L361 (MIC=10 ?M), Pseudomonas fluorescens (MIC=50 ?M), Salmonella Salford (MIC>50 ?M), Escherichia coli O:9 (MIC=15 ?M);##Gram-positive bacteria: Bacillus cereus (MIC=20 ?M), Listeria monocytogenes (MIC=10 ?M), Staphylococcus aureus (MIC>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8980754 Antimicrob Agents Chemother. 1997 Jan;41(1):54-59. "Hoek KS, Milne JM, Grieve PA, Dionysius DA, Smith R." Antibacterial activity in bovine lactoferrin-derived peptides. DRAMP03825 KKLGAPSITCVRRAFA 16 CNBr-cleaved lactoferricin Subfragment 2 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None "Function: Subfragment 2 had weak antibacterial activity against L. monocytogenes and both E. coli isolates, being effective in the range of 40 to 60 ?M." "Gram-negative bacteria: Escherichia coli L361 (MIC=50 ?M), Pseudomonas fluorescens (MIC>100 ?M), Salmonella Salford (MIC>100 ?M), Escherichia coli O:9 (MIC=60 ?M);##Gram-positive bacteria: Bacillus cereus (MIC>100 ?M), Listeria monocytogenes (MIC=40 ?M), Staphylococcus aureus (MIC>100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8980754 Antimicrob Agents Chemother. 1997 Jan;41(1):54-59. "Hoek KS, Milne JM, Grieve PA, Dionysius DA, Smith R." Antibacterial activity in bovine lactoferrin-derived peptides. DRAMP03826 KNLRRIIRKIIHIIKKYG 18 Ovispirin-1 (OV-1; N-terminal 18 amino acids of SMAP-29) No entry found Not found Not found Synthetic construct "Antibacterial, Cytotoxic, Anti-Gram+, Anti-Gram-, Antimicrobial" Synthetic Alpha helix (1 helices; 13 residues) Ovispirin-1 is a uniform -helix over residues 4-16. 1HU5 resolved by NMR. "Function: Possess potently antimicrobial activity. It is also highly cytotoxic to human epithelial cells (ME-180 cervical cells: 100% at 200 ?g/ml, 93.6% at 50 ?g/ml, 55.3% at 25 ?g/ml) and A-549 pulmonary cells: 99.7% at 200 ?g/ml, 99.4% at 50 ?g/ml, 90.9% at 25 ?g/ml) and hemolytic for human Human red blood cells." "[Ref.11932493]Gram-negative bacteria: Pseudomonas aeruginosa 9 strains (MIC=0.7-5.6 ?g/ml), Stenotrophomonas maltophilia 5 strains (MIC=0.5-2.2 ?g/ml);##Gram-positive bacteria: Listeria monocytogenes EGD [n=3] (MIC=1.50.3 ?g/ml), Staphylococcus aureus 930918 [n=3] (MIC=1.00.13 ?g/ml)." "[Ref.11932493]55% hemolytic at 40 ?g/mL, 70.2% hemolytic activity at 80 ?g/mL against human red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11932493 Protein Eng. 2002 Mar;15(3):225-232. "Sawai MV, Waring AJ, Kearney WR, McCray PB Jr, Forsyth WR, Lehrer RI, Tack BF." Impact of single-residue mutations on the structure and Function: of ovispirin/novispirin antimicrobial peptides. DRAMP03827 KNLRRIIRKGIHIIKKYG 18 Novispirin G-10 (mutation of Ovispirin-1) No entry found Not found Not found Synthetic construct "Antibacterial, Cytotoxic, Anti-Gram+, Anti-Gram-, Antimicrobial" Synthetic Alpha helix (2 helices; 11 residues) "Novispirin G-10 shows an -helix-hinge-310 helix structural motif with residues 4-11 forming the -helix, residues 12 and 13 forming the hinge and residues 14-16 forming the 310 helix." 1HU6 resolved by NMR. "Function: Possess potently antimicrobial activity. Also has hemolytic activity against Human red blood cells, and has cytotoxicity activity against ME-180 cervical cells (33.2% at 200 ?g/ml, 5.0% at 50 ?g/ml, 7.1% at 25 ?g/ml) and A-549 pulmonary cells (33.2% at 200 ?g/ml, 14.6% at 50 ?g/ml, 10.0% at 25 ?g/ml)." "[Ref.11932493]Gram-negative bacteria: Pseudomonas aeruginosa 9 strains (MIC=0.11-12.7 ?g/ml), Stenotrophomonas maltophilia 5 strains (MIC=0.29-3.6 ?g/ml);##Gram-positive bacteria: Listeria monocytogenes EGD [n=3] (MIC=1.40.4 ?g/ml), Staphylococcus aureus 930918 [n=3] (MIC=4.61.7 ?g/ml)." "[Ref.11932493]1.8% hemolytic at 40 ?g/mL, 2.5% hemolytic activity at 80 ?g/mL against human red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11932493 Protein Eng. 2002 Mar;15(3):225-232. "Sawai MV, Waring AJ, Kearney WR, McCray PB Jr, Forsyth WR, Lehrer RI, Tack BF." Impact of single-residue mutations on the structure and Function: of ovispirin/novispirin antimicrobial peptides. DRAMP03828 KNLRRITRKIIHIIKKYG 18 Novispirin T-7 (mutation of Ovispirin-1) No entry found Not found Not found Synthetic construct "Antibacterial, Cytotoxic, Anti-Gram+, Anti-Gram-, Antimicrobial" Synthetic Alpha helix (1 helices; 11 residues) Novispirin T-7 is a well-defined -helix over residues 7-17 with residues 3-6 forming a type IV turn. 1HU7 resolved by NMR. "Function: Possess potently antimicrobial activity. Also has hemolytic activity against Human red blood cells, and has cytotoxicity activity against ME-180 cervical cells (81.5% at 200 ?g/ml, 28.4% at 50 ?g/ml, 15.6% at 25 ?g/ml) and A-549 pulmonary cells (81.5% at 200 ?g/ml, 22.9% at 50 ?g/ml, 15.4% at 25 ?g/ml)." "[Ref.11932493]Gram-negative bacteria: Pseudomonas aeruginosa 9 strains (MIC=0.26-27.8 ?g/ml), Stenotrophomonas maltophilia 5 strains (MIC=0.32-1.75 ?g/ml);##Gram-positive bacteria: Listeria monocytogenes EGD (MIC=2.41.5 [n=3] ?g/ml), Staphylococcus aureus 930918 (MIC=3.31.5 [n=3] ?g/ml)." "[Ref.11932493]3% hemolytic at 40 ?g/mL, 10% hemolytic activity at 80 ?g/mL against human red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11932493 Protein Eng. 2002 Mar;15(3):225-232. "Sawai MV, Waring AJ, Kearney WR, McCray PB Jr, Forsyth WR, Lehrer RI, Tack BF." Impact of single-residue mutations on the structure and Function: of ovispirin/novispirin antimicrobial peptides. DRAMP03829 GLKKLLGKLLKKLGKLLLK 19 GLK-19 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-, Anticancer" Synthetic Not found Not found None Function: GLK-19 showed a higher activity against Escherichia coli than human LL-37. Gram-negative bacterium: Escherichia coli K12 (MIC=10 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18957441 Nucleic Acids Res. 2009 Jan;37(Database issue):D933-937. "Wang G, Li X, Wang Z." APD2: the updated antimicrobial peptide database and its application in peptide design. DRAMP03830 GLWNSIKIAGKKLFVNVLDKIRCKVAGGCKTSPDVEYHK 39 Palustrin-2ISb + 3aa No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), S. aureus (MRSA) (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-3 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03831 GLWNSIKIAGKKLFVNVLDKIRCKVAGGC 29 Palustrin-2ISb-des-C7 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=1.6 ?M), S. aureus (MRSA) (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys23 and Cys29). Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-4 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03832 GLWDSIKIAGKKLFVNVLDKIRCKVAGGC 29 Palustrin-2ISb-des-C7-4D No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), S. aureus (MRSA) (MIC=12.5 ?M);##yeast Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys23 and Cys29). Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-5 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03833 GLWNSIKIAGKNLFVNVLDKIRCKVAGGC 29 Palustrin-2ISb-des-C7-12N No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), S. aureus (MRSA) (MIC=12.5 ?M);##yeast Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys23 and Cys29). Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-6 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03834 GLWNSIKIAGKKLFVNVLDKIRSKVAGGS 29 "Palustrin-2ISb-des-C7-23,29S" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=3.1 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), S. aureus (MRSA) (MIC=25 ?M);##yeast Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-7 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03852 GLARIVVIRVAR 12 G1 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=125 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=125 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03853 RGARIVVIRVAR 12 G2 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=31 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03854 RRARIVVIRVAR 12 R2 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=16 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03855 RLRRIVVIRVAR 12 R3 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03856 RLWRIVVIRVAR 12 W3 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.5 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03857 RLARRVVIRVAR 12 R5 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=63 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=125 ?g/ml).##Yeast: Candida albicans (MIC=125 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03858 RLARIVKIRVAR 12 K7 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=125 ?g/ml), Staphylococcus epidermidis (MIC=31 ?g/ml), Enterococcus faecalis (MIC=125 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03859 RLARIVVIRWAR 12 W10 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03860 RLARIVVIRVRR 12 R11 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03861 RLARIVVIRVAG 12 G12 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=63 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=31 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=63 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03862 RLRRIVVIRVRR 12 Sub2 (Bac2A variant through two amino acids substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03863 RRWRIVVIRVRR 12 Sub3 (Bac2A variant through three amino acids substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2 ?g/ml), Escherichia coli (MIC=2.5 ?g/ml), Salmonella typhimurium (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03864 RRWKIVVIRWRR 12 Sub5 (Bac2A variant through five amino acids substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.5 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03865 RWWKIWVIRWWR 12 Sub6 (Bac2A variant through six amino acids substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=1 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml).." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03866 KIWVIRWR 8 Bac8a (Bac2A variant) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=16 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03867 RIWVIRWR 8 Bac8b (Bac2A variant) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03868 RIWVIWRR 8 Bac8c (Bac2A variant) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03869 RRWVIWRR 8 Bac8d (Bac2A variant) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=250 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=8 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml).##Yeast: Candida albicans (MIC=63 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03870 RLARIVVIRVAR 12 Bac2A (a linear variant of bovine dodecapeptide) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=50 ?g/ml), Escherichia coli (MIC=17 ?g/ml), Salmonella (MIC=34 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=17 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=17 ?g/ml).##Yeast: Candida albicans (MIC=9 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366##17052614 Nat Biotechnol. 2005 Aug;23(8):1008-1012.Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE. Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity.Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP03871 YQWQRRMRKL 10 "cLf 20-29 (fragment of caprine lalctoferricin, residues 20-29)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=308 ?M), Escherichia coli (wild strain) (MIC>300 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=308 ?M), Enterococcus faecalis ATCC 29212 (MIC>300 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 13677384 Am J Vet Res. 2003 Sep;64(9):1088-1092. "Chen PW, Shyu CL, Mao FC." Antibacterial activity of short hydrophobic and basic-rich peptides. DRAMP03875 RRWQWRMKKL 10 "bLf 20-29 (fragment of bovine lactoferricin, residues 20-29)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.25 ?M), Escherichia coli (wild strain) (MIC=5.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=15 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 13677384 Am J Vet Res. 2003 Sep;64(9):1088-1092. "Chen PW, Shyu CL, Mao FC." Antibacterial activity of short hydrophobic and basic-rich peptides. DRAMP03876 RRWWWRWRRW 10 LFB-RW (derivative of bovine lactoferrin with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?M), Escherichia coli (wild strain) (MIC=5.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=11.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 13677384 Am J Vet Res. 2003 Sep;64(9):1088-1092. "Chen PW, Shyu CL, Mao FC." Antibacterial activity of short hydrophobic and basic-rich peptides. DRAMP03877 KKWWWKWKKW 10 LFB-KW (derivative of bovine lactoferrin with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.25 ?M), Escherichia coli (wild strain) (MIC=7.50 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=22.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 13677384 Am J Vet Res. 2003 Sep;64(9):1088-1092. "Chen PW, Shyu CL, Mao FC." Antibacterial activity of short hydrophobic and basic-rich peptides. DRAMP03878 RRWWRRWRRW 10 LFB-Rwa (derivative of bovine lactoferrin with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?M), Escherichia coli (wild strain) (MIC=5.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=22.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 13677384 Am J Vet Res. 2003 Sep;64(9):1088-1092. "Chen PW, Shyu CL, Mao FC." Antibacterial activity of short hydrophobic and basic-rich peptides. DRAMP03879 RRFFFRFRRF 10 LFB-RF (derivative of bovine lactoferrin with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=22.5 ?M), Escherichia coli (wild strain) (MIC=15 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15 ?M), Enterococcus faecalis ATCC 29212 (MIC=22.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 13677384 Am J Vet Res. 2003 Sep;64(9):1088-1092. "Chen PW, Shyu CL, Mao FC." Antibacterial activity of short hydrophobic and basic-rich peptides. DRAMP03880 RRIIIRWRRI 10 LFB-RI (derivative of bovine lactoferrin with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.63 ?M), Escherichia coli (wild strain) (MIC=3.75 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=15 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 13677384 Am J Vet Res. 2003 Sep;64(9):1088-1092. "Chen PW, Shyu CL, Mao FC." Antibacterial activity of short hydrophobic and basic-rich peptides. DRAMP03881 RRWWWR 6 LFB-6RW (derivative of bovine lactoferrin with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=22.5 ?M), Escherichia coli (wild strain) (MIC=22.5 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=30 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 13677384 Am J Vet Res. 2003 Sep;64(9):1088-1092. "Chen PW, Shyu CL, Mao FC." Antibacterial activity of short hydrophobic and basic-rich peptides. DRAMP03882 SKCYQWQRRMRKLGA 15 "LFC (fragment of mature caprine lactoferrin, residues 17 to 31)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=252 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>500 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03883 TKCFQWQWNMRKVRG 15 LFH W8 (tryptophan-modified human lactoferricin derivative) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=74 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>500 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03884 SKCYQWQWRMRKLGA 15 LFC W8 (tryptophan-modified caprine lactoferricin derivative) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=174 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>500 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03885 SKCRQWQWKIRRTNP 15 LFP W8 (tryptophan-modified porcine lactoferricin derivative) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=219 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>500 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03886 FKCRRWQWRMKKLGA 15 "LFB (fragment of bovine lalctoferricin, residues 17 to 31)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=24 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=48 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives. DRAMP03887 AKCRRWQWRMKKLGA 15 "LFB A1 (derivative of LFB, residue substitution with alanine at position 1)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=35 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03888 FACRRWQWRMKKLGA 15 "LFB A2 (derivative of LFB, residue substitution with alanine at position 2)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=40 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03889 FKARRWQWRMKKLGA 15 "LFB A3 (derivative of LFB, residue substitution with alanine at position 3)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=51 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03890 FKCARWQWRMKKLGA 15 "LFB A4 (derivative of LFB, residue substitution with alanine at position 4)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=35 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03891 FKCRAWQWRMKKLGA 15 "LFB A5 (derivative of LFB, residue substitution with alanine at position 5)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=61 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03892 FKCRRWAWRMKKLGA 15 "LFB A7 (derivative of LFB, residue substitution with alanine at position 7)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=15 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=75 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03893 FKCRRWQWAMKKLGA 15 "LFB A9 (derivative of LFB, residue substitution with alanine at position 9)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=28 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03894 FKCRRWQWRAKKLGA 15 "LFB A10 (derivative of LFB, residue substitution with alanine at position 10)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=70 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03895 FKCRRWQWRMAKLGA 15 "LFB A11 (derivative of LFB, residue substitution with alanine at position 11)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=35 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03896 FKCRRWQWRMKALGA 15 "LFB A12 (derivative of LFB, residue substitution with alanine at position 12)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03897 FKCRRWQWRMKKAGA 15 "LFB A13 (derivative of LFB, residue substitution with alanine at position 13)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03898 FKCRRWQWRMKKLAA 15 "LFB A14 (derivative of LFB, residue substitution with alanine at position 14)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=77 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11095180 J Pept Res. 2000 Nov;56(5):265-274. "Str??m MB, Rekdal O, Svendsen JS." Antibacterial activity of 15-residue lactoferricin derivatives DRAMP03899 AKCLRWQWEMRKVGG 15 LFM A1 W8 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=391 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03900 AKCLRWQWAMRKVGG 15 "LFM A1,9 W8 (LFM W8 derivative with residues substitution)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=134 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03901 RKCLRWQWEMRKVGG 15 LFM R1 W8 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=37 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=374 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03902 EKCLRWQWRMRKVGG 15 LFM R9 W8 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03903 AKCLRWQWRMRKVGG 15 LFM A1 R9 W8 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=31 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=257 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03904 RKCLRWQWAMRKVGG 15 LFM A9 R1 W8 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=31 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=257 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03905 RKCLRWQWRMRKVGG 15 "LFM R1,9 W8 (LFM W8 derivative with residues substitution)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=37 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03906 AKCLRWQWEMRKYGG 15 LFM A1 W8 Y13 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=151 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03907 AKCLRWQWAMRKYGG 15 "LFM A1,9 W8 Y13 (LFM W8 derivative with residues substitution)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=88 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03908 RKCLRWQWEMRKYGG 15 LFM R1 W8 Y13 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=19 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=73 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03909 EKCLRWQWRMRKYGG 15 LFM R9 W8 Y13 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=63 ?M) No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03910 AKCLRWQWRMRKYGG 15 LFM A1 R9 W8 Y13 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=40 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03911 RKCLRWQWAMRKYGG 15 LFM A9 R1 W8 Y13 (LFM W8 derivative with residues substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03912 RKCLRWQWRMRKYGG 15 "LFM R1,9 W8 Y13 (LFM W8 derivative with residues substitution)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli. Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11168896 J Pept Res. 2001 Feb;57(2):127-139. "Str??m MB, Rekdal O, Stensen W, Svendsen JS." Increased antibacterial activity of 15-residue murine lactoferricin derivatives. DRAMP03920 KWKLFKKIEKVGQGIGAVLKVLTTGL 26 Cecropin A (1-8)-melittin (1-13)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.7 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Streptococcus pyogenes (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa OT97 (MIC=1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03921 KWKLFKKIGIGAVLKVLTTGLPALIS 26 Cecropin A (1-8)-melittin (1-18)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.3 ?M), Pseudomonas aeruginosa OT97 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.4 ?M), Bacillus megaterium Bm11 (MIC=0.4 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Streptococcus pyogenes (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03922 KWKLFKKIGIGAVLKVLTTG 20 Cecropin A (1-8)-melittin (1-12)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.4 ?M), Pseudomonas aeruginosa OT97 (MIC=0.9 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.3 ?M), Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Streptococcus pyogenes (MIC=0.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03923 KWKLFKKIGIGAVLKVLT 18 Cecropin A (1-8)-melittin (1-10)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa OT97 (MIC=3 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.3 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=7 ?M), Streptococcus pyogenes (MIC=0.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03924 KWKLFKKGIGAVLKV 15 Cecropin A (1-7)-melittin (1-8)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=4 ?M), Pseudomonas aeruginosa OT97 (MIC=15 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=1.4 ?M), Bacillus megaterium Bm11 (MIC=0.8 ?M), Staphylococcus aureus Cowan 1 (MIC=29 ?M), Streptococcus pyogenes (MIC=0.7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03925 KWKLFKKGAVLKVLT 15 Cecropin A (1-7)-melittin (3-10)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=3 ?M), Pseudomonas aeruginosa OT97 (MIC=15 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=3 ?M), Bacillus megaterium Bm11 (MIC=0.9 ?M), Staphylococcus aureus Cowan 1 (MIC>200 ?M), Streptococcus pyogenes (MIC=1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03927 KWKLFKKIGAVLKVL 15 Cecropin A (1-7)-melittin (2-9)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Alpha helix (1 helices; 10 residues) Adopts an amphipathic helix almost parallel to the surface of the micelle. 2JMY resolved by NMR. CAMEL is also a hybrid peptide obtained by combining residues 1-7 of cecropin (CA) and residues 2-9 of melittin (M). "Gram-negative bacteria: Escherichia coli D21 (MIC=1 ?M), Pseudomonas aeruginosa OT97 (MIC=4 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.5 ?M), Bacillus megaterium Bm11 (MIC=0.7 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Streptococcus pyogenes (MIC=0.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777##17397158 FEBS Lett. 1992 Jan 20;296(2):190-194.##J Am Chem Soc. 2007 Apr 25;129(16):5228-5234. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG.##Respondek M, Madl T, G?bl C, Golser R, Zangger K." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.##Mapping the orientation of helices in micelle-bound peptides by paramagnetic relaxation waves. DRAMP03928 KWKLFKKAVLKVLTT 15 Cecropin A (1-7)-melittin (4-11)hybrid peptide (CAM) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.6 ?M), Pseudomonas aeruginosa OT97 (MIC=4 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.6 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=8 ?M), Streptococcus pyogenes (MIC=0.7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777##20111863 FEBS Lett. 1992 Jan 20;296(2):190-194.##Curr Microbiol. 2010 Sep;61(3):169-175. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG.##Cao Y, Yu RQ, Liu Y, Zhou HX, Song LL, Cao Y, Qiao DR." "Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.##Design, recombinant expression, and antibacterial activity of the cecropins-melittin hybrid antimicrobial peptides." DRAMP03929 KWKLFKKVLKVLTTG 15 Cecropin A (1-7)-melittin (5-12)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa OT97 (MIC=2 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.3 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=8 ?M), Streptococcus pyogenes (MIC=0.4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03930 KWKLFKKLKVLTTGL 15 Cecropin A (1-7)-melittin (6-13)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=2 ?M), Pseudomonas aeruginosa OT97 (MIC=8 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=51 ?M), Streptococcus pyogenes (MIC=0.4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03933 IIYCNRRTGKCQRM 14 "I14M (truncated isoform of thanatin, residue 8-21)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-positive bacteria: Aerococcus viridans (MIC=1.2-2.5 ?M), Micrococcus luteus (MIC=5-10 ?M), Bacillus megaterium (MIC=10-20 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=20-40 ?M), Escherichia coli D31 (MIC=20-40 ?M), Klebsiella pneumoniae (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=20-40 ?M), Botrytis cinerea (MIC=10-20 ?M), Alternaria brassicicola (MIC=5-10 ?M), Fusarium culmorum (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8577744 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA." "Structure-activity analysis