DRAMP_ID	Sequence	Sequence_Length	Name	Swiss_Prot_Entry	Family	Gene	Source	Activity	Protein_existence	Structure	Structure_Description	PDB_ID	Comments	Target_Organism	Hemolytic_activity	Linear/Cyclic/Branched	N-terminal_Modification	C-terminal_Modification	Other_Modifications	Stereochemistry	Cytotoxicity	Binding_Traget	Pubmed_ID	Reference	Author	Title
DRAMP00089	TTKNYGNGVCNSVNWCQCGNVWASCNLATGCAAWLCKLA	39	Bacteriocin E50-52 (Preclinical)	P85148	Belongs to the class IIa bacteriocin	Not found	Enterococcus faecium (Streptococcus faecium) (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Bacteriocin active against the Gram-negative bacteria and the Gram-positive bacteria. When added to the drinking water of chickens, causes a decrease in the levels of Campylobacter jejuni and S. enteritidis in the ceca, and in the levels of S.enteritidis in the liver and spleen."	"Gram-negative bacteria: Campylobacter jejuni (MIC=0.025-6.4 ?g/ml), Yersinia enterocolitica, Yersinia pseudotuberculosis, Escherichia coli O157:H7 (MIC<1.6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=0.2-0.8 ?g/ml), Staphylococcus epidermidis (MIC=0.2-0.8 ?g/ml), Listeria monocytogenes (MIC=2-8 ?g/ml), Listeria grayi, Listeria innocua, Listeria ivanovii, Listeria denitrificans (MIC=32 ?g/ml), Morganella morganii, Salmonella spp., Shigella dysenteriae."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	None	L	No cytotoxicity information found	Not found	18293921	J Agric Food Chem. 2008 Mar 26;56(6):1942-1948.	"Svetoch EA, Eruslanov BV, Perelygin VV, Mitsevich EV, Mitsevich IP, Borzenkov VN, Levchuk VP, Svetoch OE, Kovalev YN, Stepanshin YG, Siragusa GR, Seal BS, Stern NJ."	Diverse antimicrobial killing by Enterococcus faecium E 50-52 bacteriocin.
DRAMP00107	TNYGNGVGVPDAIMAGIIKLIFIFNIRQGYNFGKKAT	37	Bacteriocin L-1077	No entry found	Belongs to the class IIa bacteriocin	Not found	Lactobacillus salivarius L-1077 (NRRL B-50053) (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Salmonella Enteritidis 1 (MIC=0.19 ug/ml), S. Enteritidis 4 (MIC=0.38 ug/ml), S. Enteritidis 204 (MIC=0.38 ug/ml), S. Enteritidis 237 (MIC=0.19 ug/ml), Salmonella Choleraesuis 434/4 (MIC=0.38 ug/ml), S. Choleraesuis 370 (MIC=0.19 ug/ml), Salmonella Typhimurium 483/6 (MIC=0.19 ug/ml), S. Typhimurium 44/8 (MIC=0.19 ug/ml), Salmonella Gallinarum-Pullorum (MIC=0.19 ug/ml), Escherichia coli HB 101 (MIC=0.19 ug/ml), E. coli-600 (MIC=0.19 ug/ml), E. coli O157:H7 Y-63 (MIC=0.19 ug/ml), E. coli O157:H7 G-35 (MIC=0.19 ug/ml), E. coli O157:H7 OD 30 (MIC=0.19 ug/ml), E. coli O157:H7 T lab 39 (MIC=0.19 ug/ml), Yersinia enterocolitica 03 (MIC=0.76 ug/ml), Y. enterocolitica 09 (MIC=0.76 ug/ml), Y. enterocolitica 11 (MIC=0.76 ug/ml), Citrobacter freundii (MIC=0.76 ug/ml), Klebsiella pneumoniae (MIC=0.76 ug/ml), Shigella dysenteriae (MIC=0.76 ug/ml), Yersinia pseudotuberculosis 4 (MIC=0.76 ug/ml), Y. pseudotuberculosis 99/14 (MIC=0.76 ?g/ml), Pseudomonas aeruginosa 508 (MIC=0.38 ug/ml), Proteus mirabilis (MIC=0.38 ug/ml), Morganella morganii (MIC=0.38 ?g/ml), Proteus vulgaris 7A (MIC=1.5 ug/ml),Campylobacter jejuni L-4 (MIC=0.09 ug/ml);##Gram-positive bacteria: Clostridium perfringens? 13124 (MIC=0.7 ug/ml), Listeria monocytogenes A 9-72 (MIC=0.19 ug/ml), Staphylococcus aureus (MIC=0.76 ug/ml), Staphylococcus epidermidis (MIC=0.76 ug/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	None	L	No cytotoxicity information found	Not found	21378051	Appl Environ Microbiol. 2011 Apr;77(8):2749-2754. 	"Svetoch EA, Eruslanov BV, Levchuk VP, Perelygin VV, Mitsevich EV, Mitsevich IP, Stepanshin J, Dyatlov I, Seal BS, Stern NJ."	"Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum."
DRAMP00136	NRWYCNSAAGGVGGAAVCGLAGYVGEAKENIAGEVRKGWGMAGGFTHNKACKSFPGSGWASG	62	Enterocin E-760 (Bacteriocin)	P85147	Belongs to the class IIb bacteriocin	Not found	Enterococcus sp. (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: The enterocin demonstrated thermostability by retaining activity after 5 min at 100 degrees C and was stable at pH values between 5.0 and 8.7. However, activity was lost below pH 3.0 and above pH 9.5. No hemolytic activity."	"[Ref.18086839]Gram-positive bacteria: Listeria monocytogenes 9-72 (MIC=0.1 ¦Ìg/ml), Staphylococcus epidermidis (MIC=1.6 ¦Ìg/ml), S. aureus (MIC=1.6 ¦Ìg/ml);##Gram-negative bacteria: S. enterica serovar Enteritidis 1 (MIC=0.2 ¦Ìg/ml), S. enterica serovar Enteritidis 4 (MIC=0.4 ¦Ìg/ml), S. enterica serovar Enteritidis 204 (MIC=0.2 ¦Ìg/ml), S. enterica serovar Enteritidis 237 (MIC=0.2 ¦Ìg/ml), S. enterica serovar Choleraesuis 434/4 (MIC=0.4 ¦Ìg/ml), S. enterica serovar Choleraesuis 370 (MIC=0.4 ¦Ìg/ml), S. enterica serovar Typhimurium 383/60 (MIC=0.4 ¦Ìg/ml), S. enterica serovar Typhimurium 320 (MIC=0.2 ¦Ìg/ml), S. enterica serovar Gallinarum biovar Pullorum (MIC=0.4 ¦Ìg/ml), Escherichia coli HB101 (MIC=0.1 ¦Ìg/ml), E. coli C600 (MIC=0.1 ¦Ìg/ml), E. coli O157:H7 Y-63 (MIC=1.6 ¦Ìg/ml), E. coli O157:H7 G-3 (MIC=1.6 ¦Ìg/ml), E. coli O157:H7 OD-3 (MIC=1.6 ¦Ìg/ml), E. coli O157:H7 T-39 (MIC=1.6 ¦Ìg/ml), Yersinia enterocolitica 03 (MIC=0.1 ¦Ìg/ml), Y. enterocolitica 09 (MIC=0.1 ¦Ìg/ml), Y. enterocolitica 04 (MIC=0.1 ¦Ìg/ml), Y. pseudotuberculosis ser 4 (MIC=3.2 ¦Ìg/ml), Y. pseudotuberculosis 14 (MIC=3.2 ¦Ìg/ml), Citrobacter freundii (MIC=1.6 ¦Ìg/ml), Klebsiella pneumoniae (MIC=3.2 ¦Ìg/ml), Shigella dysenteriae (MIC=0.1 ¦Ìg/ml), Campylobacter jejuni L4 (MIC=0.1 ¦Ìg/ml), Campylobacter P 1-R (MIC=0.2 ¦Ìg/ml), Campylobacter P-45 (MIC=0.4 ¦Ìg/ml), Campylobacter lari R (MIC=0.2 ¦Ìg/ml), Campylobacter LB 6-R (MIC=0.1 ¦Ìg/ml), Campylobacter C/D (MIC=0.2 ¦Ìg/ml),."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	None	L	No cytotoxicity information found	Not found	18086839	Antimicrob Agents Chemother. 2008 Mar;52(3):1094-1100.	"Line JE, Svetoch EA, Eruslanov BV, Perelygin VV, Mitsevich EV, Mitsevich IP, Levchuk VP, Svetoch OE, Seal BS, Siragusa GR, Stern NJ."	Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and Gram-negative bacteria.
DRAMP00171	LIDHLGAPRWAVDTILGAIAVGNLASWVLALVPGPGWAVKAGLATAAAIVKHQGKAAAAAW	61	Lactocyclicin Q (Bacteriocin)	B9ZZY0	Belongs to the class IIc bacteriocin	lycQ	Lactococcus sp. strain QU 12 (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Lactococcus sp.strain QU 12 (MIC=34.3 ?M), Lactococcus lactis subsp.lactis JCM 7638 (MIC=0.141 ?M), L. lactis subsp.lactis ATCC 19435 (MIC=0.141 ?M), L. lactis subsp.lactis IL1403 (MIC=0.141 ?M), L. lactis QU 1 (MIC=0.141 ?M), L. lactis subsp.cremoris ATCC 19275 (MIC=0.283 ?M), Lactococcus raffinolactis JCM 5706 (MIC=0.71 ?M), Lactobacillus sakei subsp.sakei JCM 1157 (MIC=0.015 ?M), Lactobacillus casei subsp.casei JCM 1134 (MIC=2.27 ?M), Leuconostoc brevis JCM 1059 (MIC=1.14 ?M), L. acidophilus JCM 1132 (MIC=2.86 ?M), L. coryniformis subsp.coryniformis JCM 1164 (MIC=2.86 ?M), L. kimchii JCM 10707 (MIC=0.71 ?M), L. mesenteroides subsp.mesenteroides JCM 6124 (MIC=1.03 ?M), Weissella cibaria JCM 12495 (MIC=0.71 ?M), Pediococcus pentosaceus JCM 5885 (MIC=0.55 ?M), P. pentosaceus JCM 5890 (MIC=2.86 ?M), P. acidilactici JCM 8797 (MIC=2.86 ?M), P. dextrinicus JCM 5887 (MIC=0.141 ?M), Enterococcus faecium JCM5804 (MIC=0.71 ?M), E. hirae ATCC 10541 (MIC=0.71 ?M), E. durans NBRC 100479 (MIC=0.71 ?M), E. faecalis JCM 5803 (MIC=0.26 ?M), Streptococcus salivarius JCM 5707 (MIC=22.9 ?M), S. bovis JCM 5802 (MIC=22.9 ?M), Bacillus coagulans JCM 2257 (MIC=0.015 ?M), B. circulans JCM 2504 (MIC=0.031 ?M), B. subtilis JCM 1465 (MIC=0.064 ?M), B. cereus JCM 2152 (MIC=11.4 ?M), Micrococcus luteus IFO 12708 (MIC=5.7 ?M), Listeria innocua ATCC 33090 (MIC=1.03 ?M), L. monocytogenes ATCC BAA-679 (MIC=1.03 ?M), Staphylococcus aureus subsp.aureus ATCC 12600 (MIC=91.6 ?M);
Gram-negative bacteria: Escherichia coli JM109 (MIC=34.3 ?M), E. coli NBRC 3301 (MIC=17.3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Cyclization (N termini to C termini)	Cyclization (C termini to N termini)	The whole peptide has a cyclic structure in which N and C termini are bound to each other.	L	No cytotoxicity information found	Not found	19139222##21948835	Appl Environ Microbiol. 2009 Mar;75(6):1552-1558.##Appl Environ Microbiol. 2011 Nov;77(22):8164-8170. 	"Sawa N, Zendo T, Kiyofuji J, Fujita K, Himeno K, Nakayama J, Sonomoto K.##Masuda Y, Ono H, Kitagawa H, Ito H, Mu F, Sawa N, Zendo T, Sonomoto K."	"Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus sp. strain QU 12.##Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401."
DRAMP00191	GGAGHVPEYFVGIGTPISFYG	21	Microcin J25 (MccJ25; Bacteriocin)	Q9X2V7	Belongs to the class I microcin	mcjA	Escherichia coli AY25 (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Beta strand	"MccJ25 does not have a head-to-tail cyclic structure but rather a side chain to backbone cyclization between Glu8 and the N-terminus. This creates an embedded ring that is threaded by the C-terminal tail of the molecule, forming a noose-like feature. The three-dimensional structure deduced from NMR data suggests that slippage of the noose is prevented by two aromatic residues flanking the embedded ring."	"1Q71, 1PP5 resolved by NMR."	"Function: Microcin J25 is a 21 amino acid bacterial peptide that has potent antibacterial activity against Gram-negative bacteria, resulting from its interaction with RNA polymerase.
Induction: At the onset of stationary growth phase.
PTM: Isoglutamyl glycine isopeptide between G1 and E8."	"Gram-negative bacteria: Escherichia coli BM21 (MIC=0.08 ?g/ml), E. coli AB1133 (MIC=0.02 ?g/ml), E. coli RYC816 (MIC=0.04 ?g/ml), E. coli AY29 (MIC=0.04 ?g/ml), Salmonella species, Shigella flexneri."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Cyclization of a N-terminal between Gly and Glu	Free	None	L	No cytotoxicity information found	Not found	1429464##10092860##14531690##14531661	J Bacteriol. 1992 Nov;174(22):7428-7435.##Eur J Biochem. 1999 Feb;259(3):747-755.##J Am Chem Soc. 2003 Oct 15;125(41):12464-74.##J Am Chem Soc. 2003 Oct 15;125(41):12382-3.	"Salom?n RA, Far?as RN.##Blond A, P?duzzi J, Goulard C, Chiuchiolo MJ, Barth?l?my M, Prigent Y, Salom?n RA, Far?as RN, Moreno F, Rebuffat S.##Rosengren KJ, Clark RJ, Daly NL, G?ransson U, Jones A, Craik DJ.##Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH."	"Microcin 25, a novel antimicrobial peptide produced by Escherichia coli.##The cyclic structure of microcin J25, a 21-residue peptide antibiotic from Escherichia coli.##Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone.##Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot."
DRAMP00222	GETDPNTQLLNDLGNNMAWGAALGAPGGLGSAALGAAGGALQTVGQGLIDHGPVNVFIPVLIGPSWNGSGSGYNSATSSSGSGS	84	Microcin E492 (MccE492; Bacteriocin)	Q9Z4N4	Not found	mceA	Klebsiella pneumoniae RYC492 (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Channel-forming bacteriocin. Forms cation-selective channels. Active on enterobacteria, with highest activity against Escherichia coli. The unmodified protein is active against Escherichia coli and S. enteritidis. When the siderophore ester is present at Ser-99, antibacterial activity against these species is increased and activity is also detected against E. cloacae and K. pneumoniae.
PTM: The C-terminal Ser is modified by attachment to a siderophore similar to enterobactin, which can bind one atom of iron. The modification consists of an ester linkage of the serine carboxyl to O6 of a glucose which is linked by a C-glycosidic bond to the 5'-benzoyl of a linear triester of N-(2,3-dihydroxybenzoyl)serine. Presence of the siderophore ester increases the antibacterial activity of the protein."	"Gram-negative bacteria: Escherichia coli F (MIC=0.14 ?M), Escherichia coli 363 (MIC=0.02 ?M), Escherichia coli ML35p (MIC=0.14 ?M), Escherichia coli GM1 (MIC=0.04 ?M), Escherichia coli GM1 KP1060(MIC=0.65 ?M), Escherichia coli W3110 (MIC=0.02 ?M), Escherichia coli W3110-KP1344 Pms7 (MIC=0.08 ?M), Escherichia coli W3110-6 (MIC=0.32 ?M), Escherichia coli C600 (MIC=0.08 ?M), Escherichia coli C600 pHX405 (MIC=0.16 ?M), Salmonella enteritidis (MIC=0.6 ?M), Salmonella typhimurium (MIC=1.2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Attachment to a siderophore ester	"[Ref.15102848] The post-translational modification consists of a trimer of N-(2,3-dihydroxybnenzoyl)-L-serine linked via a C-glycosidic linkage to a ¦Â-D-glucose moiety, itself linked to the MccE492m Ser-84-carboxyl through an O-glycosidic bond."	L	No cytotoxicity information found	Not found	12890026##15102848##7682973	Mol Microbiol. 2003 Aug;49(4):1031-1041.##J Biol Chem. 2004 Jul 2;279(27):28233-28242.##FEBS Lett. 1993 Apr 26;321(2-3):145-148.	"Destoumieux-Garz?n D, Thomas X, Santamaria M, Goulard C, Barth?l?my M, Boscher B, Bessin Y, Molle G, Pons AM, Letellier L, Peduzzi J, Rebuffat S.##Thomas X, Destoumieux-Garz?n D, Peduzzi J, Afonso C, Blond A, Birlirakis N, Goulard C, Dubost L, Thai R, Tabet JC, Rebuffat S.##Lagos R, Wilkens M, Vergara C, Cecchi X, Monasterio O."	"Microcin E492 antibacterial activity: evidence for a TonB-dependent inner membrane permeabilization on Escherichia coli.##Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity.##Microcin E492 forms ion channels in phospholipid bilayer membrane."
DRAMP00336	IPCGESCVWIPCITAIAGCSCKNKVCYT	28	ChaC7 (Chassatide C7; uncyclotides; Plant defensin)	No entry found	"Belongs to the Bracelet subfamily, Rubiaceae family"	Not found	Chassalia chartacea	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"IC50=1.2 ?M, HD50=11.6 ?M.
Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)."	"Gram-negative bacterium: Escherichia coli (MIC=6.4 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)."	[Ref.22467870] HD50 = 11.6 ¦ÌM against on human red blood cells (Type A). Kalata B1 and melittin were used as the positive control.	Linear	Free	Free	None	L	[Ref.22467870] IC50 = 1.2 ¦ÌM targeting on HeLa cells. Kalata B1 was used as the positive control.	Not found	22467870	J Biol Chem. 2012 May 18;287(21):17598-17607.	"Nguyen GK, Lim WH, Nguyen PQ, Tam JP."	Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.
DRAMP00337	AIPCGESCVWIPCISTVIGCSCSNKVCYR	29	ChaC8 (Chassatide C8; uncyclotides; Plant defensin)	No entry found	"Belongs to the Bracelet subfamily, Rubiaceae family"	Not found	Chassalia chartacea	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"IC50=1.0 ?M, HD50=25.5 ?M.
Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)."	"Gram-negative bacterium: Escherichia coli (MIC=6.6 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)."	[Ref.22467870] HD50 = 25.5 ¦ÌM against human red blood cells (Type A). Kalata B1 and melittin were used as the positive control.	Linear	Free	Free	None	L	[Ref.22467870] IC50 = 1.0 ¦ÌM targeting on HeLa cells. Kalata B1 was used as the positive control.	Not found	22467870	J Biol Chem. 2012 May 18;287(21):17598-17607.	"Nguyen GK, Lim WH, Nguyen PQ, Tam JP."	Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.
DRAMP00338	IPCGESCVWIPCISGMFGCSCKDKVCYS	28	ChaC11 (Chassatide C11; uncyclotides; Plant defensin)	No entry found	"Belongs to the Bracelet subfamily, Rubiaceae family"	Not found	Chassalia chartacea	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"IC50=1.2 ?M, HD50=13.3 ?M.
Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)."	"Gram-negative bacterium: Escherichia coli (MIC=8.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)."	[Ref.22467870] HD50 = 13.3 ¦ÌM against human red blood cells (Type A). Kalata B1 and melittin were used as the positive control.	Linear	Free	Free	None	L	[Ref.22467870] IC50 = 5.0 ¦ÌM targeting on HeLa cells. Kalata B1 was used as the positive control.	Not found	22467870	J Biol Chem. 2012 May 18;287(21):17598-17607.	"Nguyen GK, Lim WH, Nguyen PQ, Tam JP."	Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.
DRAMP00385	QLPICGETCVLGGCYTPNCRCQYPICVR	28	Panitide L2 (plants)	No entry found	Not found	Not found	Panicum laxum	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Bridge	Not found	None	PTM: N-terminus is a pyruglutamyl.	Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Pyroglutamyl modification	Free	There are three disulfide bonds in the peptide structure	L	[Ref.23195955] IC50 = 6.0 ¦ÌM against HeLa cells. 	Not found	23195955	J Biol Chem. 2013 Feb 1;288(5):3370-3380.	"Nguyen GK, Lian Y, Pang EW, Nguyen PQ, Tran TD, Tam JP."	Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants.
DRAMP00431	KTCMTKKEGWGRCLIDTTCAHSCRKYGYMGGKCQGITRRCYCLLNC	46	Defensin-like protein 2 (Cp-thionin II; Cp-thionin-2; Gamma-thionin II; Plant defensin)	P84920	Belongs to the DEFL family	Not found	Vigna unguiculata (Cowpea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli and P. syringae. Does not have antibacterial activity against the phytopathogenic bacteria R. solanacearum, Rhataybacter sp and Erwinia sp. Does not inhibit trypsin, chymotrypsin or alpha-amylases.
Tissue specificity: Present in seeds, cotyledons and leaves. Not found in roots or stems.
Developmental stage: Present in seeds and seedlings, levels decrease with seedling age. Light increases the rate of degradation. Present until 9 days in seedlings kept in the dark, not found after 6 days in seedings kept in the light.
PTM: Contains four disulfide bonds 3-46; 13-33; 19-40; 23-42."	"Gram-positive bacterium: Staphylococcus aureus ATTC 25923 (MIC=128 mg/ml);##Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=64 mg/ml), Pseudomonas syringae (MIC=42 mg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization of a C-terminal Cys residue (forming a disulfide bond)	"There are four disulfide bonds between Cys3 and Cys46, Cys13 and Cys33, Cys19 and Cys40, Cys23 and Cys42"	L	No cytotoxicity information found	Not found	16824043	FEBS J. 2006 Aug;273(15):3489-3497. 	"Franco OL, Murad AM, Leite JR, Mendes PA, Prates MV, Bloch C Jr."	Identification of a cowpea gamma-thionin with bactericidal activity.
DRAMP00764	KSLRPRCWIKIKFRCKSLKF	20	Piceain 1 (Plants)	No entry found	Not found	Not found	Picea sitchensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Beta strand (CD)	Not found	None	"Function: Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells.
PTM: Contains one disulfide bond."	"Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 ?g/ml), S. aureus ATCC 43300 (MIC=9.38 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=18.75 ?g/ml), Escherichia coli ML-35P (MIC=18.75 ?g/ml), Escherichia coli 08040722 (CI) (MIC=75 ?g/ml), Escherichia coli 08A866 (CI) (MIC=37.5 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 ?g/ml).##Yeast: Candida albicans ATCC 20032 (MIC=9.38 ?g/ml)."	"[Ref.21644248] At the concentration of 0.0625 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.7% & 1.5%; At the concentration of 0.125 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 7.2%; At the concentration of 0.25 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.9%&7.8%; At the concentration of 0.5 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.6% & 9.5%; At the concentration of 1 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.8% & 57.1%."	Cyclic	Free	Free	There is one intra-molecular disulfide bridge formed by Cys7 and Cys15.	L	No cytotoxicity information found	Not found	21644248	J Pept Sci. 2011 Sep;17(9):627-631.	"Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R."	Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis.
DRAMP00765	RPRCWIKIKFRCKSLKF	17	Piceain 2 (Plants)	No entry found	Not found	Not found	Picea sitchensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells.
PTM: Contains one disulfide bond."	"Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 ?g/ml), S. aureus ATCC 43300 (MIC=18.75 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=37.5 ?g/ml), Escherichia coli ML-35P (MIC=37.5 ?g/ml), Escherichia coli 08040722 (CI) (MIC=75 ?g/ml), Escherichia coli 08A866 (CI) (MIC=37.5 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=18.75 ?g/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 ?g/ml).##Yeast: Candida albicans ATCC 20032 (MIC=18.75 ?g/ml)."	"[Ref.21644248] At the concentration of 0.0625 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.6% & 2.2%; At the concentration of 0.125 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 4.7%; At the concentration of 0.25 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.2%&5.2%; At the concentration of 0.5 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.3% & 12.4%; At the concentration of 1 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 11.3% & 66.3%."	Cyclic	Free	Free	There is one intra-molecular disulfide bridge formed by Cys4 and Cys12.	L	No cytotoxicity information found	Not found	21644248	J Pept Sci. 2011 Sep;17(9):627-631.	"Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R."	Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis.
DRAMP00766	KVFLGLK	7	JCpep7 (Plants)	No entry found	Not found	Not found	Jatropha curcas	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: JCpep7 killed microbes principally via breaking of their cell walls and membranes, followed by cell lysis."	"Gram-negative bacteria: Salmonella typhimurium ATCC 50013 (MIC=48 ?g/ml), Shigella dysenteriae ATCC 51302 (MIC=48 ?g/ml), Pseudomonas aeruginosa ATCC 27553 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=40 ?g/ml), Bacillus subtilis ATCC 23631 (MIC=24 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC=56 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	None	L	No cytotoxicity information found	Not found	21268582	J Agric Food Chem. 2011 Feb 23;59(4):1145-1151.	"Xiao J, Zhang H, Niu L, Wang X."	Efficient Screening of a Novel Antimicrobial Peptide from Jatropha curcas by Cell Membrane Affinity Chromatography.
DRAMP00774	GTRCGETCFVLPCWSAKFGCYCQKGFCYRN	30	Hedyotide B1 (hB1; Plants)	No entry found	Belongs to the cyclotide family	Not found	Hedyotis biflora (aerial tissues)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=3.4 ?M);##Gram-positive bacteria: Streptococcus salivarius(MIC=5.9 ?M), Staphylococcus epidermidis (MIC>80 ?M), S. aureus (MIC>80 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	There are three disulfide bonds in the peptide structure	L	No cytotoxicity information found	Not found	21979955	J Biol Chem. 2011 Dec 30;286(52):44833-44844.	"Nguyen GK, Zhang S, Wang W, Wong CT, Nguyen NT, Tam JP."	Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry.
DRAMP00795	GIPCGESCVFIPCITAAIGCSCKSKVCYRN	30	Cliotide T1 (cT1; Plant defensin)	No entry found	Belongs to the cyclotide family	Not found	Clitoria ternatea (Butterfly pea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"Function: Cliotide T1 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=7.1 ?M) and cytotoxicity against HeLa Cells (IC50=0.6 ?M).
[Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. "	"[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC=1.1 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC=2.7 ?M), Klebsiella pneumonia ATCC 13883 (MIC=4.7 ?M)."	[Ref.21596752] HD50 = 7.1 ¦ÌM against human red blood cells	Cyclic	Free	Free	"There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27."	L	[Ref.21596752] IC50=0.6 ?M against HeLa cells.	Not found	21596752	J Biol Chem. 2011 Jul 8;286(27):24275-24287.	"Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP."	Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family.
DRAMP00798	GIPCGESCVFIPCITGAIGCSCKSKVCYRN	30	Cliotide T4 (cT4; Plant defensin)	No entry found	Belongs to the cyclotide family	Not found	Clitoria ternatea (Butterfly pea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"Function: Cliotide T4 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=8.4 ?M) and cytotoxicity against HeLa Cells (IC50=0.6 ?M).
[Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. "	"[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC=1.3 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC=1.9 ?M), Klebsiella pneumonia ATCC 13883 (MIC=1.5 ?M)."	[Ref.21596752] HD50 = 8.4 ¦ÌM against human red blood cells	Cyclic	Free	Free	"There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27."	L	[Ref.21596752] IC50=0.6 ?M against HeLa cells.	Not found	21596752	J Biol Chem. 2011 Jul 8;286(27):24275-24287.	"Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP."	Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family.
DRAMP00856	GLPVCGETCVGGTCNTPGCTCSWPVCTRN	29	Kalata-B1 (Plant defensin)	P56254	Belongs to the cyclotide family	OAK1	Oldenlandia affinis 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Protein level	Beta strand (3 strands; 7 residues)	Not found	2KHB resolved by NMR.	"Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans. Active against the Gram-positive S. aureus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. Inhibitory effect on the growth and development of larvae from H. punctigera. The unmodified form has hemolytic activity, the oxidized form lacks hemolytic activity. If the protein is linearized, hemolytic activity is lost.
MOA: a small number of cyclotides bind to the membrane surface and then insert first into the outer membrane leaflet followed by penetration through the membrane and pore formation. At higher concentrations of cyclotides, destabilization of membranes occurs.
Tissue specificity: Leaves and stems. Lower in roots.
Pharmaceutical use: The uteroactive properties of Kalata have been discovered by African traditional medicine. It is used as an ingredient of a herbal tea to accelerate childbirth.
PTM: Kalata-B1 is a cyclic peptide which contains three disulfide bonds 5-19; 11-21; 14-26."	"[Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.26 ?M), Micrococcus luteus (MIC=40.4 ?M);##Gram-negative bacterium: Klebsiella oxytoca (MIC=54.8 ?M);##Fungi: Candida kefyr (MIC=21.4 ?M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=140 nM)."	[Ref.12779323] HD50 = 300 ¦ÌM against Human type A red blood cells.	Cyclic	Cyclization (N termini to C termini)	Cyclization (C termini to N termini)	"[Ref.7703226] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys26."	L	[Ref.18008336]CEM-SS cells:IC50=3500 nM.	Cell membrance	18008336##10430870##7703226##17534989##23129773	Biopolymers. 2008;90(1):51-60.##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biochemistry. 1995 Apr 4;34(13):4147-4158.##Chembiochem. 2007 Jun 18;8(9):1001-1011.##J Biol Chem. 2012 Dec 21;287(52):43884-98. 	"Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, G?ransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ."	"Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions."
DRAMP00877	GIPCGESCVWIPCISAALGCSCKNKVCYRN	30	Circulin-A (CIRA; Plant defensin)	P56871	Belongs to the cyclotide family	Not found	Chassalia parviflora 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal"	Protein level	Alpha helix (1 helices; 4 residues)	"The molecule is stabilised by three disulfide bonds, two of which form an embedded loop completed by the backbone fragments connecting the cysteine residues. A third disulfide bond threads through the centre of this loop to form a ""cystine-knot"" motif. This motif is present in a range of other biologically active proteins, including omega-contoxin GVIA and Cucurbita maxima trypsin inhibitor."	1BH4 resolved by NMR.	"Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa.
PTM: This is a cyclic peptide which contains three disulfide bonds 1-17; 5-19; 10-24."	[Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.19 ?M).##Gram-negative bacterium: Proteus vulgaris (MIC=54.6 ?M).##Fungi: Candida kefyr (MIC=18.6 ?M) and Candida tropicalis (MIC=19.4 ?M).##NOTE: Medium with 10 mM phosphate buffer.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM).	[Ref.10430870] EC50 = 1020 ¦ÌM against blood type A human erythrocytes.	Cyclic	Cyclization (N termini to C termini)	Cyclization (C termini to N termini)	"[Ref.8920961] There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27"	L	[Ref.18008336]CEM-SS cells:IC50=500 nM.	Not found	18008336##10430870##9878410##8920961	Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. ##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J. Mol. Biol. 1999; 285:333-345. ##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8.	"Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##Tam JP, Lu YA, Yang JL, Chiu KW.##Daly NL, Koltay A, Gustafson KR, Boyd MR, Casas-Finet JR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell"	"Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides"
DRAMP00878	GVIPCGESCVFIPCISTLLGCSCKNKVCYRN	31	Circulin-B (CIRB; Plant defensin)	P56879	Belongs to the cyclotide family	Not found	Chassalia parviflora 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal"	Protein level	Beta strand (5 strands; 10 residues)	Cyclotides are mini-proteins derived from plants that have the characteristic features of a head-to-tail cyclised peptide backbone and a knotted arrangement of their three disulfide bonds.	2ERI resolved by NMR.	"Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria.
PTM: This is a cyclic peptide which contains three disulfide bonds 5-21; 9-23; 14-28."	"[Ref.10430870]Gram-positive bacterium: (L-salt): Staphylococcus aureus (MIC=13.5 ?M).##Gram-negative bacteria: (L-salt, H-salt) (MIC ?M): Escherichia coli (0.41, >500), Pseudomonas aeruginosa (25.5, 48), Proteus vulgaris (6.8, >500), Klebsiella oxytoca (8.2, 15.6).##Fungi (H-salt): Candida kefyr (MIC=29 ?M).##NOTE: L-salt = Medium with 10 mM phosphate buffer; H-salt = L-salt supplemented with 100 mM NaCl.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM)."	[Ref.10430870] EC50 = 550 ¦ÌM against blood type A human erythrocytes.	Cyclic	Cyclization (N termini to C termini)	Cyclization (C termini to N termini)	"[Ref.8920961] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys27."	L	[Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 820 ¦ÌM.##[Ref.18008336]CEM-SS cells:IC50=500 nM.	Not found	10430870##18008336##8920961	Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biopolymers. 2008;90(1):51-60.##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. doi: 10.1006/bbrc.1996.1708.	"Tam JP, Lu YA, Yang JL, Chiu KW.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell"	"An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclotides as natural anti-HIV agents.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides"
DRAMP01374	GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC	33	"Odorranain-D1 (OdD1; Frogs, amphibians, animals)"	A6MBK7	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Odorranain-D1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=16.32 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8.16 ¦Ìg/ml), Bacillus subtilis (MIC=8.16 ¦Ìg/ml).##Yeast: Candida albicans (MIC=4.08 ¦Ìg/ml)."	[Ref:17272268]Non-hemolytic activity against rabbit red blood cells	Cyclic	Free	Cyclization(Cys27 and Cys33)	Disulfide bridge between Cys27 and Cys33.	L	[Ref.17272268]No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01373	GVLGAVKDLLIGAGKSAAQSVLKTLSCKLSNDC	33	"Odorranain-C1 (OdC1; Frogs, amphibians, animals)"	A6MBF6	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Odorranain-C1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=8.21 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.11 ¦Ìg/ml), Bacillus subtilis (MIC=16.42 ¦Ìg/ml).##Yeast: Candida albicans (MIC=2.05 ¦Ìg/ml)."	[Ref:17272268] No detectable hemolytic activity against rabbit red blood cells.	Cyclic	Free	Cyclization of a C-terminal Cys residue (forming a disulfide bond)	[Ref:17272268] There are one disulfide bond between Cys27 and Cys33	L	No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01372	AALKGCWTKSIPPKPCFGKR	20	"Odorranain-B1 (OdB1; Frogs, amphibians, animals)"	E7EKD9	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Odorrana hainanensis (Odor frog) (Rana hainanensis)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Homology	Not found	Odorranain-B1 adopts 5.9 % 	None	"Function: Odorranain-B1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. 
Tissue specificity: Expressed by the skin glands."	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.21 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=5.83 ¦Ìg/ml), Bacillus subtilis (MIC=1.85 ¦Ìg/ml).##Yeast: Candida albicans (MIC=2.4 ¦Ìg/ml)."	[Ref:17272268] No detectable hemolytic activity against rabbit red blood cells.	Cyclic	Free	Free	[Ref:17272268] There are one disulfide bond between Cys6 and Cys16	L	No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01012	RESPSSRMECYEQAERYGYGGYGGGRYGGGYGSGRGQPVGQGVERSHDDNRNQPR	55	Pg-AMP (Gly-rich; Plants)	P86030	Not found	Not found	Psidium guajava (Guava)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-negative bacteria. Does not have antifungal activity against the human and plant pathogenic fungi F. oxysporum, A. fumigatus and R. solani. 
Subunit structure: Monomer and homodimer. Might act by homodimer formation."	"Gram-negative bacteria: Klebsiella sp., Proteus sp., Escherichia coli ATCC 8739 (MIC=72 mg/ml), Klebsiella pneumoniae (MIC=32 mg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	None	L	No cytotoxicity information found	Not found	18448201	Peptides. 2008 Aug;29(8):1271-1279.	"Pelegrini PB, Murad AM, Silva LP, Dos Santos RC, Costa FT, Tagliari PD, Bloch C Jr, Noronha EF, Miller RN, Franco OL."	Identification of a novel storage glycine-rich peptide from guava (Psidium guajava) seeds with activity against Gram-negative bacteria.
DRAMP01018	SIPCGESCVFIPCTVTALLGCSCKSKVCYKN	31	Cyclopsychotride-A (CPT; Plant defensin)	P56872	Not found	Not found	Psychotria longipes 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria.
PTM: This is a cyclic peptide which may contain three disulfide bonds 4-21; 8-23; 13-28."	"Gram-negative bacteria: Escherichia coli (MIC=1.55 ?M), Pseudomonas aeruginosa (MIC=13.5 ?M), Proteus vulgaris (MIC=13.2 ?M), Klebsiella oxytoca (MIC=5.80 ?M).##Gram-positive bacteria: Staphylococcus aureus (MIC=39.0 ?M), Micrococcus luteus (MIC=48.0 ?M).##Fungi: Candida albicans (MIC>500 ?M), Candida kefyr (MIC=14.0 ?M), Candida tropicalis (MIC=56.5 ?M).##NOTE: Medium with 10 mM phosphate buffer."	[Ref.10430870] HD50 = 405 ¦ÌM against blood type A human erythrocytes.	Cyclic	Cyclization (N termini to C termini)	Cyclization (C termini to N termini)	"There are three disulfide bonds between Cys4 and Cys21, Cys8 and Cys23, Cys13 and Cys28"	L	[Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 1850 ¦ÌM.	Not found	10430870##7714530	Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J Nat Prod. 1994 Dec;57(12):1619-1625.	"Tam JP, Lu YA, Yang JL, Chiu KW.##Witherup KM, Bogusky MJ, Anderson PS, Ramjit H, Ransom RW, Wood T, Sardana M. "	"An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes."
DRAMP18193	KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF	34	Cathelicidin-related peptide crotalicidin	U5KJM4	Belongs to the cathelicidin family.	Not found	Crotalus durissus terrificus (South American rattlesnake)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	alpha helical	Not found	2MWT resolved by NMR	"Function: Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane (By similarity). Hemolytic activities have been observed on mammalian cells. Expressed by the venom gland."	"[Ref.25100358]Gram-negative: E.coli ATCC 25922 (MIC=0.25 ¦Ìg/mL),P.aeruginosa (MIC=1 ¦Ìg/mL);##Gram-positive: E.faecalis (MIC=32 ¦Ìg/mL), S.aureus (MIC=32 ¦Ìg/mL)."	"[Ref.25100358] Crotalicidin reached 10% hemolysis at 25 ¦ÌM. Even so, extrapolation of existing data indicates that 50% hemolysis would be reached at near-millimolar values, which defines an adequate (~2 log) selectivity window."	Cyclic	Free	Amidation	None	L	No cytotoxicity information found	cell membrane	25100358	Amino Acids 46:2561-2571(2014)	"Falcao C.B., de La Torre B.G., Perez-Peinado C., Barron A.E.,Andreu D., Radis-Baptista G."	Vipericidins: a novel family of cathelicidin-related peptides fromthe venom gland of South American pit vipers.
DRAMP01064	AWKLFDDGV	9	Anticancerous peptide 1 (Cr-ACP1; Plants)	B3EWE7	Not found	Not found	Cycas revoluta (Sago palm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Protein level	Not found	Not found	None	"Function: The synthetic peptide inhibits cell proliferation and induces apoptosis in cancer-derived cell lines Hep2 (IC50=1.5 mM) and HCT15 and, to a lesser extent, in non-cancerous NIH/3T3 cells. The mode of action is presumably an arrest in the G0/G1 phase. Antiproliferative, proapoptotic and DNA-binding activities are increased by acetylation at Ala-1 and Lys-3. Has a weak hemolytic activity against mouse erythrocytes. Has antibacterial activity. Antibacterial activity is decreased by acetylation. "	"[Ref.21882228]Gram-positive bacteria: Staphylococcus epidermidis (MIC=60 ?M), Bacillus subtilis (MIC=30 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=30 ?M), EEscherichia coli strain ATCC 8739 (MIC=30 ?M)."	[Ref.21882228] Hemocompatibility study revealed the effectiveness of both the peptides where it showed no significant lysis of normal RBC cells compare to positive control (Triton X-100). Cr-ACP1 induced hemolysis of 7% at the conentration of 1 mM.	Linear	Free	Free	None	L	[Ref.21882228] IC50 = 1.5 mM in Hep2 (Human epidermoid cancer cells); IC50 = 0.9 mM in HCT15 (human colon carcinoma cells HCT15); Cr-ACP1 induced a cell viability of 66% at the concentration of 4 mM.	DNA	21882228	J Cell Biochem. 2012 Jan;113(1):184-193.	"Mandal SM, Migliolo L, Das S, Mandal M, Franco OL, Hazra TK."	Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties.
DRAMP01066	PVVDTTGNNPLQQQEEYYV	19	Kunitz-type serine protease inhibitor 1 (Xb-KTI; Plants)	P86930	Not found	Not found	Xanthosoma sagittifolium (Elephant's ear) (Arum sagittifolium)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Serine protease inhibitor. Displays antimicrobial activity against the Gram-negative bacterium S. typhimurium ATCC 14028. Displays a weak hemolytic activity.	[Ref.21520894]Gram-negative bacterium: Salmonella typhimurium ATCC 14028 (MIC=10 ?M).	[Ref.21520894] No hemolytic activity was observed for Xb-KTI. The peptide induced a hemolysis of 12% at the highest concentration of 250 ¦Ìg/mL. Values(OD540) were normalized against 100% lysed erythrocytes (0.1% Triton X-100) and PDB (untreated control)	Linear	Free	Free	None	L	No cytotoxicity information found	Not found	21520894	J Nat Prod. 2011 May 27;74(5):969-975.	"Lima TB, Silva ON, Migliolo L, Souza-Filho CR, Gon?alves EG, Vasconcelos IM, Oliveira JT, Amaral AC, Franco OL."	A Kunitz proteinase inhibitor from corms of Xanthosoma blandum with bactericidal activity.
DRAMP01081	GLKDIFKAGLGSLVKGIAAHVAN	23	"Alyteserin-1a (toads, amphibians, animals)"	No entry found	Not found	Not found	Alytes obstetricans (European midwife toad)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	"Function: The alyteserin-1 peptides show selective growth inhibitory activity against the Gram-negative bacterium Escherichia coli. The hemolytic activity against human erythrocytes of all peptides tested is relatively weak.
Structural similarity: The alyteserin-1 peptides show limited structural similarity to the ascaphins from the skins of frogs of the family Leiopelmatidae."	[Ref.19463738]Gram-negative bacterium: Escherichia coli (MIC=25 ?M).	[Ref:19463738] LC50 > 100 ¦ÌM against human erthrocytes. Alyteserin-1a induced a hemolysis of 11% at the concentration of 100 ¦ÌM.	Linear	Free	¦Á-Amidation	None	L (to be determined)	No cytotoxicity information found	Not found	19463738	Peptides. 2009 Jun;30(6):1069-1073.	"Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC."	The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).
DRAMP01083	GLKEIFKAGLGSLVKGIAAHVAN	23	"Alyteserin-1b (toads, amphibians, animals)"	No entry found	Not found	Not found	Alytes obstetricans (European midwife toad)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Amtimicrobial peptide. (By similarity)	Gram-negative bacterium: Escherichia coli (MIC=25 ?M).	[Ref:19463738] LC50 = 210 ¦ÌM against human erthrocytes. 	Linear	Free	¦Á-Amidation	None	L (to be determined)	No cytotoxicity information found	Not found	19463738	Peptides. 2009 Jun;30(6):1069-1073.	"Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC."	The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).
DRAMP01085	GLKEIFKAGLGSLVKGIAAHVAS	23	"Alyteserin-1c (toads, amphibians, animals)"	H0USY4	Not found	Not found	Alytes obstetricans (Common midwife toad) (Bufo obstetricans)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Alpha helix	"Solution structural studies in the membrane mimicking environments, sodium dodecyl sulphate (SDS), dodecylphosphocholine (DPC), and 1,2-dihexanoyl-sn-glycero-3-phosphatidylcholine (DHPC) micelles, indicate that these peptides display an alpha helical structure between residues Lys(3) and Val(21).(Ref.1)"	2L5R resolved by NMR.	Function: Alyteserin-1c shows selective growth-inhibitory activity against Gram-negative bacteria.	Gram-negative bacterium: Escherichia coli (MIC=25 ?M).	[Ref:19463738] LC50 = 145 ¦ÌM against human erthrocytes.	Linear	Free	¦Á-Amidation	None	L (to be determined)	No cytotoxicity information found	Not found	21565166##19463738	Biochim Biophys Acta. 2011 Aug;1808(8):1975-1984.##Peptides. 2009 Jun;30(6):1069-1073.	"Subasinghage AP, O'Flynn D, Conlon JM, Hewage CM.##Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC."	Conformational and membrane interaction studies of the antimicrobial peptide alyteserin-1c and its analogue [E4K]alyteserin-1c.##The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).
DRAMP01088	GFKEVLKADLGSLVKGIAAHVAN	23	"Alyteserin-1Ma (toads, amphibians, animals)"	No entry found	Not found	Not found	Alytes maurus (Midwife toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Alyteserin-1Ma has lower antimicrobial potencies (MIC>200 ?M).	Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=214 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=214 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	¦Á-Amidation	None	L	No cytotoxicity information found	Not found	22800568	Toxicon. 2012 Nov;60(6):967-981.	"K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C."	"Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions."
DRAMP01089	GFKEVLKAGLGSLVKGIPAHVAN	23	"Alyteserin-1Mb (toads, amphibians, animals)"	No entry found	Not found	Not found	Alytes maurus (Midwife toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Alyteserin-2Ma has lower antimicrobial potencies (MIC>200 ?M).	Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=217 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=434 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	¦Á-Amidation	None	L	No cytotoxicity information found	Not found	22800568	Toxicon. 2012 Nov;60(6):967-981.	"K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C."	"Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions."
DRAMP01090	FIGKLISAASGLLSHL	16	"Alyteserin-2Ma (toads, amphibians, animals)"	No entry found	Not found	Not found	Alytes maurus (Midwife toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacteria E. coli and Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 150 microM.	Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=38.4 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=9.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	¦Á-Amidation	None	L	No cytotoxicity information found	Not found	22800568	Toxicon. 2012 Nov;60(6):967-981.	"K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C."	"Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions."
DRAMP01096	GIGSAILSAGKSALKGLAKGLAEHFAN	27	"Bombinin-like peptide 2 (BLP-2; toads, amphibians, animals)"	P29003	Belongs to the bombinin family	Not found	Bombina orientalis (Oriental fire-bellied toad)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.
Tissue specificity: Expressed by the skin glands."	"[Ref.1744108]Gram-negative bacterium: 58% inhibition Neisseria meningitidis 118V C (MIC=20 ?g/ml), 98% inhibition Neisseria meningitidis 15240 IAI (MIC=20 ?g/ml), 98% inhibition Neisseria meningitidis 126E IC1 (MIC=20 ?g/ml), 97% inhibition Neisseria gonorrhoeoe F62 (MIC=20 ?g/ml), 99% inhibition Neisseria Iactamica 15323 (MIC=20 ?g/ml), 100% inhibition Neisseria Iactamica 15215A (MIC=20 ?g/ml), 95% inhibition Neisseria cinerea 15461 (MIC=20 ?g/ml)."	[Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes.	Cyclic	Free	Amidation	None	L	No cytotoxicity information found	Not found	1744108	J. Biol. Chem. 1991; 266: 23103-23111.	"Gibson BW, Tang D, Mandrell R, Kelly M, Spindel ER."	"Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis."
DRAMP03017	FMPIIGRLMSGSL	13	"VESP-VB1 (Insects, animals)"	No entry found	Not found	Not found	vespine wasps Vespa bicolor	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Has antimicrobial activities against standard strains and strong antimicrobial ability against drug-resistant strains. Among the tested drug-resistant strains, Pseudemonas aeruginosa and Staphylococcus aureus were the most sensitive for this kind of antimicrobial peptide. Has a little hemolytic activity."	"[Ref.18723059] Gram-negative bacterium: Escherichia coli ATCC25922(MIC=7.5¦Ìg/ml), Escherichia coli 23A(MIC=7.5¦Ìg/ml), Escherichia coli 27A(MIC=15.0¦Ìg/ml), Pseudemonas aeruginosa 3A(MIC=3.75¦Ìg/ml), Pseudemonas aeruginosa 7A(MIC=3.75¦Ìg/ml), ;## Gram-positive bacterium: Staphylococcus aureus ATCC2592(MIC=1.9¦Ìg/ml), Staphylococcus aureus 6A(MIC=3.75¦Ìg/ml), Staphylococcus aureus 15A(MIC=1.0¦Ìg/ml);## Fungus: Candida albicans ATCC2002(MIC=30.0¦Ìg/ml)"	"[Ref.18723059] VESP-VB1 had a little hemolytic activity of 10.2% against rabbit red blood cells, and of 3.2% against human red blood cells with peptide concentration up to 200 ¦Ìg/ml"	Linear	Free	Free	None	L	No cytotoxicity information found	Not found	18723059	Peptides. 2008 Nov;29(11):1887-1892.	"Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, Yu H."	Antimicrobial peptides from the venoms of Vespa bicolor Fabricius.
DRAMP01098	GIGAAILSAGKSALKGLAKGLAEHF	25	"Bombinin-like peptide 3 (BLP-3; toads, amphibians, animals)"	P29004	Belongs to the bombinin family	Not found	Bombina orientalis (Oriental fire-bellied toad)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Alpha helix	Not found	None	"Function: Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.
Tissue specificity: Expressed by the skin glands."	"[Ref.1744108]Gram-postive bacterium:Bacillus megaterium BmII (MIC=0.3 ?M), Staphylococcus aureus Cowan1 (MIC=1.7 ?M);##Gram-negative bacterium:59% inhibition Neisseria meningitidis 118V C (MIC=20 ?g/ml), 99% inhibition Neisseria meningitidis 15240 IAI (MIC=20 ?g/ml), 99% inhibition Neisseria meningitidis 126E IC1 (MIC=20 ?g/ml), 99% inhibition Neisseria gonorrhoeoe F62 (MIC=20 ?g/ml), 97% inhibitionNeisseria Iactamica 15323 (MIC=20 ?g/ml), 100% inhibition Neisseria Iactamica 15215A (MIC=20 ?g/ml), 97% inhibition Neisseria cinerea 15461 (MIC=20 ?g/ml), Escherichia coli D21 (MIC=1.7 ?M), Escherichia coli D22 (MIC=1.5 ?M), Yersinia pseudotubercolosis (MIC=0.6 ?M), Pseudomonas aeruginosa ATCC 15692 (MIC=9.2 ?M);##Fungus:Candida albicans (MIC=0.4 ?M)."	[Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes.	Cyclic	Free	Amidation	None	L	No cytotoxicity information found	Not found	1744108	J Biol Chem. 1991 Dec 5;266(34):23103-23111.	"Gibson BW, Tang DZ, Mandrell R, Kelly M, Spindel ER."	"Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis."
DRAMP02090	FLPMLAGLAASMVPKFVCLITKKC	24	"Brevinin-1Lb (Frogs, amphibians, animals)"	P82826	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana luteiventris (Spotted frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against  Gram-positive and Gram-negative bacteria.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=8 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=16 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	There is a disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02091	FLPFIAGMAAKFLPKIFCAISKKC	24	"Brevinin-1Ba (Frogs, amphibians, animals)"	P82833	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana berlandieri (Rio Grande leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria. 
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=2 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP01518	GILSLFTGGIKALGKTLFKMAGKAGAEHLACKATNQC	37	"Esculentin-2L (Frogs, amphibians, animals)"	P82827	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana luteiventris (Great Basin spotted frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=3 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=6 ¦ÌM).##Yeast: Candida albicans (MIC=53 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization of a C-terminal Cys residue (forming a disulfide bond)	There is a disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP01517	GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC	37	"Esculentin-2P (Frogs, amphibians, animals)"	P82846	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pipiens (northern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram-, Antiviral"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against  Gram-negative bacteria.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-negative bacterium: Escherichia coli (MIC=10 ¦ÌM).##[Ref.11601906]Virus:##Frog Virus 3: 90% inhibition at 500 ?M;##Channel Catfish Virus: 90% inhibition at 50 ?M.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization of a C-terminal Cys residue (forming a disulfide bond)	There is a disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found in the reference(s) presented	Not found	11601906##10651828	Virology. 2001 Sep 30;288(2):351-7.##Eur J Biochem. 2000 Feb;267(3):894-900.	"Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.##Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.##Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP01516	GLFSILRGAAKFASKGLGKDLTKLGVDLVACKISKQC	37	"Esculentin-2B (Frogs, amphibians, animals)"	P82839	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana berlandieri (Rio Grande leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. 
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=1 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=1 ¦ÌM).##Yeast: Candida albicans (MIC=29 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization of a C-terminal Cys residue (forming a disulfide bond)	There is a disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02077	FLPIIAGIAAKVFPKIFCAISKKC	24	"Brevinin-1Pb (Frogs, amphibians, animals)"	Q8QFQ5	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pipiens (Northern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=5 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=14 ¦ÌM).##Yeast: Candida albicans (MIC=7 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization of a C-terminal Cys residue (forming a disulfide bond)	There is a disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	10651828##12413397	Eur J Biochem. 2000 Feb;267(3):894-900.##Biochem J. 2003 Apr 1;371(Pt 1):125-130.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.##Chen T, Farragher S.M, Bjourson A.J, Orr D.F, Rao P, Shaw C."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.##Granular gland transcriptomes in stimulated amphibian skin secretions."
DRAMP01162	AGRGKQGGKVRAKAKTRSSRAGLQFPVGRVHRLLRKGNY	39	"Buforin-1 (Buforin I; Fragment of Histone H2A; toads, amphibians, animals)"	P55897	Belongs to the histone H2A family	Not found	Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
PTM: Monoubiquitination of C-terminus gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties."	"Gram-positive bacteria: Bacillus subtilis (MIC=4 ?g/ml), Staphylococcus aureus (MIC=4 ?g/ml), Streptococcus mutans (MIC=8 ?g/ml), Streptococcus pneumoniae (MIC=4 ?g/ml), Pseudomonas putida (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=4 ?g/ml), Serratia sp. (MIC=8 ?g/ml).##Fungi: Candida albicans (MIC=4 ?g/ml), Cryptococcus neoformans (MIC=4 ?g/ml), Saccharomyces cerevisiae (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	¢ÙThe residue at position 5 is N6-(2-hydroxyisobutyryl)lysine or N6-acetyllysine. ¢ÚThe residue at position 9 is N6-(2-hydroxyisobutyryl)lysine or N6-lactoyllysine or N6-succinyllysine. ¢ÛThe Lys13 has a interchain with G-Cter in ubiquitin. ¢ÜThe Lys15 has a interchain with G-Cter in ubiquitin. ¢ÝThe residue at position 36 is N6-(2-hydroxyisobutyryl)lysine.	L	No cytotoxicity information found	DNA	8573171##8946958	Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.##FEBS Lett. 1996 Nov 25;398(1):87-90.	"Park C.B, Kim M.S, Kim S.C.##Yi G.-S, Park C.B, Kim S.C, Cheong C."	A novel antimicrobial peptide from Bufo bufo gargarizans.##Solution structure of an antimicrobial peptide buforin II.
DRAMP01163	TRSSRAGLQFPVGRVHRLLRK	21	"Buforin-2 (Buforin II; Fragment of Histone H2A; toads, amphibians, animals)"	P0DQL2	Belongs to the histone H2A family	Not found	Bufo gargarizans (Asian toad) (Bufo bufo gargarizans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed selective anticancer activity against 62 cancer cell lines (Lee 2008 Cancer Lett 271: 47-51). Buforin II is more potent than buforin I.
PTM: Monoubiquitination of C-terminus gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties."	"Gram-positive bacteria: Bacillus subtilis (MIC=2 ?g/ml), Staphylococcus aureus (MIC=4 ?g/ml), Streptococcus mutans (MIC=2 ?g/ml), Streptococcus pneumoniae (MIC=4 ?g/ml), Pseudomonas putida (MIC=2 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=1 ?g/ml), Serratia sp. (MIC=4 ?g/ml).##Fungi: Candida albicans (MIC=1 ?g/ml), Cryptococcus neoformans (MIC=1 ?g/ml), Saccharomyces cerevisiae (MIC=1 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	¢Ù The residue at position 21 is N6-(2-hydroxyisobutyryl)lysine	L	No cytotoxicity information found	DNA	8573171##8946958	Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.##FEBS Lett. 1996 Nov 25;398(1):87-90.	"Park C.B, Kim M.S, Kim S.C.##Yi G.-S, Park C.B, Kim S.C, Cheong C."	A novel antimicrobial peptide from Bufo bufo gargarizans.##Solution structure of an antimicrobial peptide buforin II.
DRAMP01164	GIGALSAKGALKGLAKGLAEHFAN	24	"Bombinin (toads, amphibians, animals)"	P01505	Not found	Not found	Bombina variegata (Yellow-bellied toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antimicrobial and hemolytic activities.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation.
Caution: Residue 20 is assigned as E by similarity to other bombin sequences instead of Z (Glutamic acid or Gutamine) given "	[Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=14 ?M).	"[Ref.8223491] The lethal concentration (LC, the lowest concentration that inhibits growth) was over 50 ¦ÌM"	Linear	Free	Amidation	None	L	No cytotoxicity information found	Not found	PubMed ID is not available##8223491	Monatsh. Chem. 1970;101:182-189.##EMBO J. 1993; 12:4829-4832.	"Csordas A, Michl H.##Mignogna G, Simmaco M, Kreil G, Barra D."	Isolation and structural resolution of a haemolytically active polypeptide from the immune secretion of a European toad.##Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.
DRAMP01167	GILDAIKAIAKAAG	14	Hylaseptin-P1 (HSP1)	P84292	Not found	Not found	Hyla punctata (Polka-dot tree frog) (Spotted tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	Function: Has antibacterial and antifungal activity. A weak hemolytic activity has been detected.	"[Ref.14715660]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.1-8.0 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=48.8-64.0 ?g/ml), Escherichia coli ATCC 25922 (MIC=24.4-32.0 ?g/ml)."	[Ref.14715660] HSP1 MIC concentration (256 ¦Ìg/mL = 195.2 ¦ÌM) produced 4.7% hemolysis against human erythrocytes.	Linear	Free	[Ref.11297740] Free  /  [Ref.32828849] Amidation	None	L	No cytotoxicity information found	Not found	14715660##32828849	"J Biol Chem. 2004 Mar 26;279(13):13018-13026. ##Biochim Biophys Acta Biomembr
. 2021 Jan 1;1863(1):183449. doi: 10.1016/j.bbamem.2020.183449. Epub 2020 Aug 21."	"Prates MV, Sfor¡ìa ML, Regis WC, Leite JR, Silva LP, Pertinhez TA, Ara?jo AL, Azevedo RB, Spisni A, Bloch C Jr.##Isabela P Gomes 1, Talita L Santos 1, Amanda N de Souza 1, L¨²cio O Nunes, Gabriele A Cardoso, Carolina O Matos, L¨ªvia M F Costa, Luciano M Li?o, Jarbas M Resende, Rodrigo M Verly"	The NMR-derived solution structure of a new cationic antimicrobial peptide from the skin secretion of the anuran Hyla punctata.##Membrane interactions of the anuran antimicrobial peptide HSP1-NH 2: Different aspects of the association to anionic and zwitterionic biomimetic systems
DRAMP01170	NLVSGLIEARKYLEQLHRKLKNCKV	25	"Distinctin 2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Phyllomedusa distincta (Tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Alpha helix (1 helices; 17 residues)	Not found	1XKM resolved by NMR	Comment: Distinctin is constituted of two different polypeptide chains connected by an intermolecular disulphide bridge. The entry is the chain 2 of Distinctin	"Note: Distinctin chain 2 links to Distinctin chain 1 to form a heterodimeric peptide to exert antibacterial function. ##Gram-positive bacteria: Enterococcus faecalis (MIC=14.5 ?M), Staphylococcus aureus (MIC=28.0 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=28.0 ?M), Escherichia coli (MIC=14.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	There is an intermolecular disulphide bridge between Distinctin chain 1 (Cys19) and Distinctin chain 2 (Cys22). 	L	No cytotoxicity information found	Not found	11297740	FEBS Lett. 2001 Apr 6;494(1-2):85-89.	"Batista CV, Scaloni A, Rigden DJ, Silva LR, Rodrigues Romero A, Dukor R, Sebben A, Talamo F, Bloch C."	A novel heterodimeric antimicrobial peptide from the tree-frog Phyllomedusa distincta.
DRAMP01174	GLLDFVTGVGKDIFAQLIKQI	21	"Ocellatin-4 (Frogs, amphibians, animals)"	P85090	Not found	Not found	Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has hemolytic activity against human erythrocytes (HC50=14.3 ?M). Has antibacterial activity.
Tissue specificity: Expressed by the skin dorsal glands."	[Ref.17884127]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=64 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=64 ?M).	[Ref.17884127] HC50 = 14.3 ¦ÌM against human O+ red blood cells	Linear	Free	Amidation	None	L	No cytotoxicity information found	Not found	17884127	Toxicon 2007; 50: 1095-1104.	Nascimento A et al Castro MS.	"Purification, characterization and homology analysis of ocellatin 4, a cytolytic peptide from the skin secretion of the frog Leptodactylus ocellatus."
DRAMP01177	GVVDILKGAAKDIAGHLASKVMNKL	25	"Ocellatin-F1 (Fallaxin; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Leptodactylus fallax (Mountain chicken frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has low hemolytic activity of fallaxin (HC50>200 ?M). 	"[Ref.15544856]Gram-negative bacteria: Escherichia coli (MIC=40 ?M), Pseudomonas aeruginosa (MIC=80 ?M), Enterobacter cloacae (MIC=20 ?M), Klebsiella pneumoniae (MIC=80 ?M)."	[Ref:15544856]HC50>200 ¦ÌM hemolytic activity of fallaxin	Linear	Free	Amidation	Free	L	[Ref.15544856]No cytotoxicity information found	Not found	15544856	Regul Pept. 2005 Jan 15;124(1-3):173-178.	"Rollins-Smith LA, King JD, Nielsen PF, Sonnevend A, Conlon JM."	An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae). 
DRAMP01182	GLLDTLKGAAKNVVGSLASKVMEKL	25	"Ocellatin-P1 (Pentadactylin; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Leptodactylus pentadactylus (South American bullfrog) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Klebsiella pneumoniae KK3 9904 (MIC=100 ?M), Enterobacter cloacae HNTCC 53001 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus epidermidis RP62A (MIC=100 ?M), Streptococcus Group B HNTCC 80130 (MIC=50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.16236555]No cytotoxicity information found	Not found	16236555	Comp Biochem Physiol C Toxicol Pharmacol. 2005 Aug;141(4):393-397.	"King JD, Al-Ghaferi N, Abraham B, Sonnevend A, Leprince J, Nielsen PF, Conlon JM."	Pentadactylin: an antimicrobial peptide from the skin secretions of the South American bullfrog Leptodactylus pentadactylus.
DRAMP01184	GVLDILKGAAKDLAGHVATKVI	22	"SPX(1-22)(truncated peptide of Syphaxin; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Leptodactylus syphax (Burgundy thin-toed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus ATCC 29213 (MIC=14.6 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=40.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.17628627]No cytotoxicity information found	Not found	17628627	Toxicon. 2007 Sep 15;50(4):572-580.	"Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F."	Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax.
DRAMP01185	GVLDILKGAAKDLAGH	16	"SPX(1-16)(truncated peptide of Syphaxin; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Leptodactylus syphax (Burgundy thin-toed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus ATCC 29213 (MIC=40.5 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.1 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.17628627]No cytotoxicity information found	Not found	17628627	Toxicon. 2007 Sep 15;50(4):572-580.	"Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F."	Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax.
DRAMP01188	LALKSGGWLRLFGLKDKKH	19	"Chensinin-1ZHa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana zhenhaiensis (Chinese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=9 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=35 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.22943378]No cytotoxicity information found	Not found	22943778	Zoolog Sci. 2012 Sep;29(9):553-558.	"Xu B, Che H, Kang L, Zheng S, Mu S, Wan F."	"Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis."
DRAMP01189	ATNIPFKVHFRCKAAFC	17	"Andersonin-W1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC>47 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>47 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=47 ?g/ml)."	[Ref:22029824] It has no hemolytic activity against human red blood cells	Cyclic	Free	Cyclization (Cys12 and Cys17)	Disulfide bond between Cys12 and Cys17.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01190	AVNIPFKVHFRCKAAFC	17	"Andersonin-W2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=20.2 ?g/ml)."	[Ref:22029824] It has no hemolytic activity against human red blood cells	Cyclic	Free	Cyclization (Cys12 and Cys17)	Disulfide bond between Cys12 and Cys17.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01191	GLFSKFAGKGIVNFLIEGVE	20	"Andersonin-X1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.3 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30.5 ?g/ml)."	[Ref:22029824]Not found	Linear	Free	Free	Free	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01192	FLPKLFAKITKKNMAHIR	18	"Andersonin-Y1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=3.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=1.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=1.6 ?g/ml)."	[Ref:22029824]Not found	Linear	Free	Free	Free	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01194	TSRCIFYRRKKCS	13	"Andersonin-C1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Show hemolytic activity against human red blood cells and obvious insulin-stimulating activity at the concentration of 50 ??g/mL.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>120 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml)."	[Ref:22029824] It has 15.2¡À2.1% hemolytic activity at 50¦Ìg/ml against human red blood cells	Cyclic	Free	Free	Disulfide bond between Cys4 and Cys12.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01195	FIFPKKNIINSLFGR	15	"Andersonin-D1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Weakly active against bacteria and fungi. Andersonin-D1 showes obvious insulin-stimulating activity at the concentration of 50 ??g/mL.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>126 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=16 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=16 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01199	RFIYMKGFGKPRFGKR	16	"Hejiangin-A1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana hejiangensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Hejiangin-A1 showes killing effects against the tested strains.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=25 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=25 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01200	IPWKLPATFRPVERPFSKPFCRKD	24	"Hejiangin-F1 (frog, amphibians, animals)"	No entry found	Not found	Not found	Odorrana hejiangensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=100 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=100 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=100 ?g/ml)."	[Ref:22029824]Non-hemolytic activity against human red blood cells	Linear	Free	Free	Free	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01201	AAPRGGKGFFCKLFKDC	17	"Schmackerin-C1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana schmackeri	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Schmackerin-C1 showes killing effects against the tested strains. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=50 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=50 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=100 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys11 and Cys17)	Disulfide bond between Cys11 and Cys17.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01208	SIITMTKEAKLPQLWKQIACRLYNTC	26	"Pleurain-A1 (Pleurain A1; Frogs, amphibians, animals)"	"A8DY01, A8DY00, A8DY02, A8DY03, A8DY04, A8DY09, A8DY10, A8DY15"	Not found	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has little hemolytic activity on red blood cells.
Tissue specificity: Expressed by the skin dorsal glands."	"[Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=30 ?g/ml);##Gram-positive bacteria: Bacillus dysenteriae (MIC=120 ?g/ml), Staphylococcus aureus ATCC 2592 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml).."	[Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 ¦Ìg/ml	Cyclic	Free	Cyclization (Cys20 and Cys26)	Disulfide bond between Cys20 and Cys26.	L	No cytotoxicity information found	Not found	17764786	Peptides. 2007 Oct;28(10):2069-2074.	"Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K."	A new family of antimicrobial peptides from skin secretions of Rana pleuraden
DRAMP01209	SIITMTKEAKLPQSWKQIACRLYNTC	26	"Pleurain-A2 (Pleurain A2; Frogs, amphibians, animals)"	A8B5P0	Not found	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has little hemolytic activity on red blood cells.
Tissue specificity: Expressed by the skin dorsal glands."	"[Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=30 ?g/ml);##Gram-positive bacteria: Bacillus dysenteriae (MIC=60 ?g/ml), Staphylococcus aureus ATCC 2592 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml)."	[Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 ¦Ìg/ml	Cyclic	Free	Cyclization (Cys20 and Cys26)	Disulfide bond between Cys20 and Cys26.	L	No cytotoxicity information found	Not found	17764786	Peptides. 2007 Oct;28(10):2069-2074.	"Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K."	A new family of antimicrobial peptides from skin secretions of Rana pleuraden.
DRAMP01214	FLGAIAAALPHVINAVTNAL	20	"Kassinatuerin-2Ma (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Kassina maculata (African hyperoliid frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Alpha helix	"Secondary structure prediction analysis revealed that virtually the entire structure of each kassinatuerin-2 related peptide is composed of alpha-helix, the helix was not amphipathic like many other amphibian skin antimicrobial peptides, in which there is a hydrophobic face and a positively charged faces the latter presumably interacting with the negatively charged glycocalyx of cell membranes."	None	"Function: Natural kassinatuerin-2Ma and their synthetic replicates possessed relatively potent growth inhibitory activity against the Gram-positive bacterium, S. aureus, but were ineffective against the Gram-negative bacterium, E. coli at concentrations up to 200 ?M and were relatively ineffective against the pathogenic yeast, C. albicans (120 ?M). Also possessed hemolytic activity as demonstrated using horse erythrocytes."	[Ref.19427345]Gram-positive bacterium: Staphylococcus aureus (NCTC 10788) (MIC=16 ?M);##Gram-negative bacterium: Escherichia coli (NCTC 10418) (MIC>200 ?M) (MIC=120 ?M);##Yeast: Candida albicans (NCPF 1467) (MIC=120 ?M).	"[Ref:19427345]18% hemolytic activity at 16 ¦ÌM, 45¨C50% hemolytic activity at 120 ¦ÌM against horse erythrocytes"	Linear 	Free	Amidation	Free	L	[Ref.19427345]No cytotoxicity information found	Not found	19427345	Peptides. 2009 Aug;30(8):1428-1433.	"Wang L, Zhou M, McGrath S, Chen T, Gorman SP, Walker B, Shaw C."	"A family of kassinatuerin-2 related peptides from the skin secretion of the African hyperoliid frog, Kassina maculata."
DRAMP01218	GFMKYIGPLIPHAVKAISDLI	21	"Kassinatuerin-1 (Frogs, amphibians, animals)"	P0C010	Not found	Not found	Kassina senegalensis (Senegal running frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: Shows broad-spectrum antimicrobial activity.
Tissue specificity: Expressed by the skin dorsal glands."	"Gram-negative bacteria: Escherichia coli (MIC=6.25 ?M), Klebsiella pneumoniae (MIC=25 ?M), Enterobacter cloacae (MIC=6.25 ?M), Pseudomonas aeruginosa (MIC=25 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 ?M), Staphylococcus epidermidis (MIC=6.25 ?M), Enterococcus faecalis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.15885852]Display cytotoxicity against L929 fibroblasts (LD50=12¦ÌM).	Not found	10679222##15885852	Biochem Biophys Res Commun. 2000 Feb 16;268(2):433-436.##Peptides. 2005 Nov;26(11):2104-2110.	"Mattute B, Knoop FC, Conlon JM.##Conlon JM, Abraham B, Galadari S, Knoop FC, Sonnevend A, P?l T."	"Kassinatuerin-1: a peptide with broad-spectrum antimicrobial activity isolated from the skin of the hyperoliid frog, Kassina senegalensis.##Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives."
DRAMP01222	GFMDTAKNVAKNVAVTLIDKLRCKVTGGC	29	"Palustrin-2AJ1 (PL2AJ1; Frogs, amphibians, animals)"	G3ETQ3	Not found	Not found	Amolops jingdongensis (Chinese torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Has hemolytic activity, low cytotoxicity and low antioxidant activity.
Tissue specificity: Expressed by the skin glands.
PTM: One disulfide bond (C23-C29) and Cleavage on pair of basic residues."	"[Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=20 ?M), Enterococcus faecalis ATCC29212 (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=13 ?M), Bacillus pyocyaneus CMCCB1010 (MIC=20 ?M), Pseudomonas aeruginosa ATCC27853 (MIC=33 ?M), Bacillus dysenteriae (MIC=50 ?M)."	[Ref:21816202] IC50=135 ¦ÌM against human and rabbit erythrocytes	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	[Ref.21816202] Cytotoxicity: the K562 (IC50=58¦ÌM) and HT29 mammalian cell lines(IC50=57¦ÌM).	Not found	21816202	Biochimie. 2012 Feb;94(2):328-334.	"Chen Z, Yang X, Liu Z, Zeng L, Lee W, Zhang Y."	"Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis."
DRAMP01227	ALFSILRGLKKLGNMGQAFVNCKIYKKC	28	"Palustrin-1b (Frogs, amphibians, animals)"	P84275	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli (MIC=8 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys22 and Cys28)	Disulfide bond between Cys22 and Cys28.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01228	ALSILRGLEKLAKMGIALTNCKATKKC	27	"Palustrin-1c (Frogs, amphibians, animals)"	"P84276, A7WNV8"	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against Gram-negative bacteria E. coli. Possesses insulin-releasing activity.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli (MIC=28 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys21 and Cys27)	Disulfide bond between Cys21 and Cys27.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01229	ALSILKGLEKLAKMGIALTNCKATKKC	27	"Palustrin-1d (Frogs, amphibians, animals)"	P84277	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli (MIC=28 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys21 and Cys27)	Disulfide bond between Cys21 and Cys27.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01231	GFFSTVKNLATNVAGTVIDTLKCKVTGGCRS	31	"Palustrin-2b (Frogs, amphibians, animals)"	"P84279, D3UA82"	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli (MIC=78 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01232	GFMDTAKNVAKNVAATLLDKLKCKITGGC	29	"Palustrin-2ISc (Frogs, amphibians, animals)"	G3XHN9	Not found	Not found	Odorrana ishikawae (Ishikawa's frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?M), Bacillus subtilis (MIC=12.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	21867685	Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-677. 	"Iwakoshi-Ukena E, Soga M, Okada G, Fujii T, Sumida M, Ukena K."	Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning.
DRAMP01233	GFLSTVKNLATNVAGTVIDTLKCKVTGGCRS	31	"Palustrin-2c (Frogs, amphibians, animals)"	P84280	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli (MIC=120 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01234	GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLNNIGNTGCNEDEC	48	"Palustrin-3a (Frogs, amphibians, animals)"	P84281	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli (MIC=1 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys43 and Cys48)	Disulfide bond between Cys43 and Cys48.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01235	GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLSNIGNTGCNEDEC	48	"Palustrin-3b (Frogs, amphibians, animals)"	P84262	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli (MIC=1 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys43 and Cys48)	Disulfide bond between Cys43 and Cys48.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01237	GFMDTAKNVAKNVAVTLLDKLKCKITGGC	29	"Palustrin-2ISa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana ishikawae	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?M), Staphylococcus aureus (MRSA) (MIC=100 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP01238	GLWNSIKIAGKKLFVNVLDKIRCKVAGGCKTSPDVE	36	"Palustrin-2SIb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana ishikawae	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), S. aureus (MRSA) (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	21911019	Peptides. 2011 Oct;32(10):2052-2057.	"Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K.2011."	Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-2 family isolated from the skin of the endangered frog Odorrana ishikawae.
DRAMP01244	FFPIGVFCKIFKTC	14	"Japonicin-1 (Frogs, amphibians, animals)"	P83305	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana japonica (Japanese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin dorsal glands.	Gram-negative bacterium: Escherichia coli (MIC=30 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys8 and Cys14)	Disulfide bond between Cys8 and Cys14.	L	No cytotoxicity information found	Not found	11835990	Peptides. 2002;23:419-425	"Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM."	Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.
DRAMP01245	FFPLALLCKVFKKC	14	"Japonicin-1CDYa (Frogs, amphibians, animals)"	B3VZU2	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Antimicrobial peptide. Lacks hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the skin glands."	[Ref.19539775]Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25 ?M).	[Ref:19539775] HC50>300 ¦ÌM against human red blood cells	Cyclic	Free	Cyclization (Cys8 and Cys14)	Disulfide bond between Cys8 and Cys14.	L	No cytotoxicity information found	Not found	19539775	Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.	"Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH."	"Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii."
DRAMP01246	FGLPMLSILPKALCILLKRKC	21	"Japonicin-2 (Frogs, amphibians, animals)"	P83306	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana japonica (Japanese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=20 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys14 and Cys21)	Disulfide bond between Cys14 and Cys21.	L	No cytotoxicity information found	Not found	11835990	Peptides. 2002;23:419-425.	"Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM."	Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.
DRAMP01249	FLIGMTQGLICLITRKC	17	"Dybowskin-2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana dybowskii (Korea brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Dybowskin-2 has hemolytic activity against human red blood cells (hRBCs).	"[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=15 ?g/ml), Bacillus subtilis ATCC6633 (MIC=25 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=25 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 ?g/ml), Escherichia coli KCTC2433 (MIC=60 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=60 ?g/ml), Proteus mirabilis ATCC25933 (MIC>100 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=100 ?g/ml)."	[Ref:17698251] It has 10.99% hemolytic activity at 100 ¦Ìg/ml against human red blood cells	Cyclic	Free	Cyclization (Cys11 and Cys17)	Disulfide bond between Cys11 and Cys17.	L	No cytotoxicity information found	Not found	17698251	Peptides 2007; 28: 1532-1539. 	"Kim SS, Shim MS, Chung J, Lim DY, Lee BJ."	Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.
DRAMP01250	GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC	33	"Dybowskin-3 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana dybowskii (Korea brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Dybowskin-3 has hemolytic activity against human red blood cells (hRBCs).	"[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=39 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=50 ?g/ml), Bacillus subtilis ATCC6633 (MIC=60 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=60 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=15 ?g/ml), Escherichia coli KCTC2433 (MIC=15 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC>100 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=100 ?g/ml)."	[Ref:17698251] It has 1.86% hemolytic activity at 100 ¦Ìg/ml against human red blood cells	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	17698251	Peptides 2007; 28: 1532-1539. 	"Kim SS, Shim MS, Chung J, Lim DY, Lee BJ."	Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.
DRAMP01251	VWPLGLVICKALKIC	15	"Dybowskin-4 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana dybowskii (Korea brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Dybowskin-4 has relatively greater hemolytic activity against human red blood cells (hRBCs).	"[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=1.56 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=3.13 ?g/ml), Bacillus subtilis ATCC6633 (MIC=6.25 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=30 ?g/ml), Escherichia coli KCTC2433 (MIC=15 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=25 ?g/ml)."	[Ref:17698251] It has 47.58% hemolytic activity at 100 ¦Ìg/ml against human red blood cells	Cyclic	Free	Cyclization (Cys9 and Cys15)	Disulfide bond between Cys9 and Cys15.	L	No cytotoxicity information found	Not found	17698251	Peptides 2007; 28: 1532-1539. 	"Kim SS, Shim MS, Chung J, Lim DY, Lee BJ."	Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.
DRAMP01252	GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC	38	"Dybowskin-5 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana dybowskii (Korea brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Dybowskin-5 has hemolytic activity against human red blood cells (hRBCs).	"[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=50 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 ?g/ml), Escherichia coli KCTC2433 (MIC=60 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=50 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=50 ?g/ml)."	[Ref:17698251] It has 17.84% hemolytic activity at 100 ¦Ìg/ml against human red blood cells	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	17698251	Peptides 2007; 28: 1532-1539. 	"Kim SS, Shim MS, Chung J, Lim DY, Lee BJ."	Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.
DRAMP01254	IIPLPLGYFAKKT	13	"Dybowskin-1CDYa (Frogs, amphibians, animals)"	B5A9S9	Not found	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M);##Gram-negative bacterium: Escherichia coli (MIC=3 ?M). 	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Free	Free	L	[Ref.19539775]No cytotoxicity information found	Not found	19539775	Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.	"Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH."	"Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii."
DRAMP01255	SAVGRHGRRFGLRKHRKH	18	"Dybowskin-2CDYa (Chensinin-1; Frogs, amphibians, animals)"	B5A9T1	Not found	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Antimicrobial peptide. Has activity against the Gram-positive bacteria: S. aureus and the Gram-negative bacteria E. coli. Lacks hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the skin glands."	"[Ref.19539775] Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-negative bacterium: Staphylococcus aureus (MIC=6 ?M).##[Ref.19341344] Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 ?M), Bacillus cereus (MIC=14.4 ?M), Streptococcus lactis (MIC=14.4 ?M)."	[Ref:19539775]HC50>300 ¦ÌM against human red blood cells	Linear 	Free	Free	Free	L	[Ref.19539775]No cytotoxicity information found##[Ref.19341344]No cytotoxicity information found	Not found	19539775##19341344	Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.##Zoolog Sci. 2009 Mar;26(3):220-226.	"Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.##Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y."	"Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.##Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis."
DRAMP01257	GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV	33	"Dermadistinctin-K (DD K; Frogs, amphibians, animals)"	P83638	Not found	Not found	Phyllomedusa distincta (Monkey frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal"	Protein level	Alpha helix	Not found	"2K9B, 2JX6 resolved by NMR."	"Function: Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes.
Tissue specificity: Expressed by the skin glands."	"Gram-positive bacteria: Staphylococcus aureus (MIC=4.7 ?M), Enterococcus faecalis (MIC>19 ?M);Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2.4 ?M), Escherichia coli (MIC=0.6 ?M).##Fungi: Candida tropicalis (MIC=10.1 ?M), Candida guilliermondii (MIC=20.3 ?M), Candida albicans (MIC=20.3 ?M), Candida albicans ATCC 1023 (MIC=10.1 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.10477123]No cytotoxicity information found	liposomes	10477123	Peptides. 1999;20(6):679-686.	"Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr."	Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
DRAMP01258	ALWKTLLKNVGKAAGKAALNAVTDMVNQ	28	"Dermadistinctin-L (DD L; Frogs, amphibians, animals)"	P83639	Not found	Not found	Phyllomedusa distincta (Monkey frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal"	Protein level	Alpha helix	Not found	None	"Function: Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes. Show little hemolytic activity against human red blood cells.
Tissue specificity: Expressed by the skin glands."	"[Ref.10477123]Gram-positive bacteria: Staphylococcus aureus (MIC=1.3 ?M), Enterococcus faecalis (MIC=10 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=40 ?M), Escherichia coli (MIC=2.5 ?M);##[Ref.17442605]Fungi: Candida tropicalis (MIC=10.9 ?M), Candida guilliermondii (MIC=21.8 ?M), Candida albicans (MIC=21.8 ?M), Candida albicans ATCC 1023 (MIC=10.9 ?M)."	[Ref:10477123]Show some hemolytic starting at 12.5 ¦ÌM against human blood	Linear	Free	Free	Free	L	[Ref.10477123]No cytotoxicity information found	liposomes	10477123##12379643##17409003##17442605	Peptides. 1999;20(6):679-686.##J Biol Chem. 2002 Dec 20;277(51):49332-49340.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):329-335.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):336-343.	"Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr.##Brand GD, Leite JR, Silva LP, Albuquerque S, Prates MV, Azevedo RB, Carregaro V, Silva JS, S?? VC, Brand??o RA, Bloch C Jr.##Silva LP, Leite JR, Brand GD, Regis WB, Tedesco AC, Azevedo RB, Freitas SM, Bloch C Jr.##Leite JR, Brand GD, Silva LP, K??ckelhaus SA, Bento WR, Ara??jo AL, Martins GR, Lazzari AM, Bloch C Jr."	"Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: liposomes fusion and/or lysis investigated by fluorescence and atomic force microscopy.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity."
DRAMP01259	ALWKTMLKKLGTMALHAGKAAFGAAADTISQ	31	"Dermadistinctin-M (DD M; Frogs, amphibians, animals)"	P83640	Not found	Not found	Phyllomedusa distincta (Monkey frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Amphibian defense peptide.
Tissue specificity: Expressed by the skin glands."	"Gram-positive bacteria: Staphylococcus aureus (MIC=38 ?M), Enterococcus faecalis (MIC>38 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=38 ?M), Escherichia coli (MIC=9.7 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.10477123]No cytotoxicity information found	Not found	10477123	Peptides. 1999;20(6):679-686.	"Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr."	Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
DRAMP01260	ALWKNMLKGIGKLAGQAALGAVKTLVGAES	30	"Dermadistinctin-Q1 (DD Q1; Frogs, amphibians, animals)"	P83641	Not found	Not found	Phyllomedusa distincta (Monkey frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Amphibian defense peptide.
Tissue specificity: Expressed by the skin glands."	"Gram-positive bacteria: Staphylococcus aureus (MIC=2.7 ?M), Enterococcus faecalis (MIC=22 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=5.4 ?M), Escherichia coli (MIC=1.3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.10477123]No cytotoxicity information found	Not found	10477123	Peptides. 1999;20(6):679-686.	"Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr."	Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
DRAMP01261	GLWSKIKEAAKTAGLMAMGFVNDMV	25	"Dermadistinctin-Q2 (DD Q2; Frogs, amphibians, animals)"	P83642	Not found	Not found	Phyllomedusa distincta (Monkey frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Amphibian defense peptide.
Tissue specificity: Expressed by the skin glands."	"Gram-positive bacteria: Staphylococcus aureus (MIC=22 ?M), Enterococcus faecalis (MIC=11 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=22 ?M), Escherichia coli (MIC=5.6 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.10477123]To produce hemolysis more than 38 ¦ÌM peptide concentrations was required. 	Not found	10477123	Peptides. 1999;20(6):679-686.	"Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr."	Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
DRAMP01301	FLSLIPHAINAVSAIAKHN	19	"Phylloseptin-1 (PS-1; Frogs, amphibians, animals)"	P84566	Not found	psn1	Phyllomedusa hypochondrialis (Orange-legged leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal"	Protein level	Alpha helix (1 helices; 14 residues)	The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2)	2JQ0 resolved by NMR.	"Function: Atomic force microscopy experiments indicated that the bacteriolytic properties of these peptides might be related to their disruptive action on the cell membrane. PS-1 did not exhibit significant hemolytic activity on human erythrocytes.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"[Ref.15752569]Gram-positive bacteria: Staphylococcus aureus (MIC=7.9 ?M), Enterococcus faecalis (MIC=4.0 ?M);##Gram-negative bacteria: Escherichia coli (MIC=7.9 ?M), Psecdomonas aeruginosa (MIC=4 ?M), Psecdomonas aeruginosa wt (MIC=3 ?M)."	"[Ref:15752569]0.3% hemolytic activity at 4 ¦ÌM, 0.57% hemolytic activity at 8 ¦ÌM, 0.6% hemolytic activity at 16 ¦ÌM, 0.98% hemolytic activity at 32 ¦ÌM, 1.98% hemolytic activity at 64 ¦ÌM against human red blood cells"	Linear 	Free	Amidation	Free	L	[REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found	Cell membrane	15752569##18656510	Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. 	"Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B."	"Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations."
DRAMP01302	FLSLIPHAINAVSTLVHHF	19	"Phylloseptin-2 (PS-2; Frogs, amphibians, animals)"	"P85881, P84567, Q0VZ43"	Not found	psn2	Phyllomedusa hypochondrialis (Orange-legged leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (1 helices; 14 residues)	The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2)	2JPY resolved by NMR.	"Function: Has antimicrobial activity. PS-2 did not exhibit significant hemolytic activity on human erythrocytes.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"[Ref.18656510][ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=15.1 ?M);##Gram-negative bacteria: Escherichia coli (MIC=60.4 ?M), Klebsiella pneumoniae (MIC=60.4 ?M), Pseudomonas aeruginosa (MIC=60.4 ?M);##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=7.6 ?M), S. agalactiae (MIC=1.9 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=60.4 ?M), A. calcoaceticus (MIC=3.7 ?M);##Fungi: Candida albicans (MIC=15.1 ?M)."	"[Ref:15752569]0.1% hemolytic activity at 4 ¦ÌM, 0.28% hemolytic activity at 4 ¦ÌM, 0.7% hemolytic activity at 8 ¦ÌM, 0.8% hemolytic activity at 16 ¦ÌM, 1.05% hemolytic activity at 32 ¦ÌM, 2.05% hemolytic activity at 64 ¦ÌM against human red blood cells"	Linear 	Free	Amidation	Free	L	[REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found	Cell membrane	15752569##18656510	Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. 	"Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B."	"Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations."
DRAMP01303	FLSLIPHAINAVSALANHG	19	"Phylloseptin-3 (PS-3; Frogs, amphibians, animals)"	P84568	Not found	psn3	Phyllomedusa hypochondrialis (Orange-legged leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (1 helices; 11 residues)	The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2)	2JQ1 resolved by NMR.	"Function: Has antimicrobial activity (By similarity).
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"[ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=32.9 ?M);##Gram-negative bacteria: Escherichia coli (MIC=65.6 ?M), Klebsiella pneumoniae (MIC=65.6 ?M), Pseudomonas aeruginosa (MIC=65.6 ?M). NOTE: Initial inoculum of 108 cells/Ml.##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=8.2 ?M), S. agalactiae (MIC=4.1 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=32.8 ?M), A. calcoaceticus (MIC=4.1 ?M).##Fungi: Candida albicans (MIC=8.2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	Free	L	[Ref.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found	Cell membrane	15752569##18656510	Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. 	"Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B."	"Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations."
DRAMP01305	FLSLIPHAINAVSAIAKHFG	20	"Phylloseptin-7 (PS-7; Frogs, amphibians, animals)"	"P84572, Q0VZ42"	Not found	psn7	Phyllomedusa hypochondrialis (Orange-legged leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-negative bacteria E. coli and P. aeruginosa, and the Gram-positive bacteria: S. aureus. No hemolytic activity.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"[Ref.16963159]Gram-negative bacteria: Escherichia coli (MIC=6 ?M), Pseudomonas aeruginosa (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M)"	[Ref:16963159]Non-hemolytic activity at 6 ¦ÌM against human erythrocytes	Linear 	Free	Amidation	Free	L	[Ref.16713656]No cytotoxicity information found	Not found	16963159##16713656	Peptides. 2006 Dec;27(12):3092-3999.##Peptides. 2006 Sep;27(9):2129-2136.	"Concei?¡ì??o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC.##Chen T, Zhou M, Gagliardo R, Walker B, Shaw C."	"Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis.##Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis."
DRAMP01306	FLSLIPHAINAVSAIAKHF	19	"Phylloseptin-7 (PS-7; Frogs, amphibians, animals)"	P85882	Not found	Not found	Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity but does not inhibit the growth of the fungus C. albicans.
Tissue specificity: Expressed by the skin glands.
PTM: Phenylalanine amide at F19."	"Gram-negative bacterium: Escherichia coli ATCC 11775 (MIC=7.2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (MIC=3.6 ?M), Micrococcus luteus ATCC 49732 (MIC=1.8 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	Free	L	[Ref.16963159]No cytotoxicity information found##[Ref.17553595]No cytotoxicity information found	Not found	17553595##16963159	Peptides. 2007 Jul;28(7):1331-1343.##Peptides. 2006 Dec;27(12):3092-3099.	"Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.##Concei??o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC."	A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.##Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis. 
DRAMP01319	RRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA	48	"Cathelicidin-AL (Gly-rich; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=6.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 ?g/ml), Bacillus subtilis (MIC=100 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 ?g/ml), Psecdomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Psecdomonas aeruginosa ATCC27853 (MIC=6.25 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Free	Free	L	[Ref.22009138]No cytotoxic against HUVEC or  RMMCs at the concentration of 0.4 mg/ml.	Not found	22009138	Amino Acids. 2012 Aug;43(2):677-685.	"Hao X, Yang H, Wei L, Yang S, Zhu W, Ma D, Yu H, Lai R."	Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate.
DRAMP01339	FLPIVGKLLSGLSGLL	16	"Amolopin-2a (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Amolops loloensis (Rufous-spotted torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Staphylococcus aureus (MIC=2.00 ?g/ml), Bacillus dysenteriae (MIC=1.50 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=3.00 ?g/ml).##Candida albicans (MIC=6.50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.17000029]Display cytotoxicity against HepG2(IC50=77 mg/ml).	Not found	17000029	Peptides. 2006 Dec;27(12):3085-3091. 	"Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R."	"Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis."
DRAMP01341	FLPLAVSLAANFLPKLFCKITKKC	24	"Amolopin-1b (Frogs, amphibians, animals)"	A0SN42	Not found	Not found	Amolops loloensis (Rufous-spotted torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Staphylococcus aureus (MIC=5.50 ?g/ml), Bacillus dysenteriae (MIC=2.20 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=6.50 ?g/ml).##Yeast: Candida albicans (MIC=7.50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization(Cys18 and Cys24)	Disulfide bridge between Cys18 and Cys24.	L	[Ref.17000029]Display cytotoxicity against HepG2(IC50=58 mg/ml).	Not found	17000029	Peptides. 2006 Dec;27(12):3085-3091. 	"Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R."	"Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis."
DRAMP01346	VIGSILGALASGLPTLISWIKNR	23	"Prepromelittin-related peptide (Frogs, amphibians, animals)"	A7BJK5	Not found	prMRP	Rana sakuraii (Japanese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).##Yeast: Candida albicans (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.17174009]No cytotoxicity information found##[Ref.17826868]No cytotoxicity information found	Not found	17174009##17826868	Peptides. 2007;28(3):505-514.##Peptides. 2007 Oct;28(10):2061-2068.	"Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Suzuki H, Conlon JM, Iwamuro S."	Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.##Evidence that the genes encoding the melittin-related peptides in the skins of the Japanese frogs Rana sakuraii and Rana tagoi are not orthologous to bee venom melittin genes: developmental- and tissue-dependent gene expression.
DRAMP01347	AIGSILGALAKGLPTLISWIKNR	23	"Prepromelittin-related peptide (Frogs, amphibians, animals)"	A7BJK6	Not found	prMRP	Rana tagoi (Tago frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Alpha helix	Not found	6dst resolved by NMR (related PDB_ID)	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Antifungal activity against C. albicans.	"[Ref.12804591]Gram-positive bacterium: Staphylococcus aureus (MIC=3.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=20 ?M).##Yeast: Candida albicans (MIC=19 ?M).##EL4 T-lymphoma cells (MIC=14 ?M).##[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=6.25 ¦ÌM), Staphylococcus epidermidis (MIC=3.13 ¦ÌM), Bacillus subtilis (MIC=3.13 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=25 ¦ÌM), Pseudomonas aeruginosa (MIC=12.5 ¦ÌM), Klebsiella pneumoniae (MIC=12.5 ¦ÌM)"	[Ref.27271216] 100% hemolysis at 20 ¦ÌM against human red blood cells	Linear	Free	Amidation	Free	L	[Ref.12804591]Display cytotoxic against L929 fibroblasts(LC50=20 ¦ÌM);EL4 T-lymphoma cells(LC50=14 ¦ÌM).##[Ref.27271216]L929 cells:Cell viability is approximately 10% at the concentration of 6.25?¦ÌM.	Not found	12804591##17174009##27271216	Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.##Peptides. 2007;28(3):505-514.##Sci Rep. 2016 Jun 8;6:27394.	"Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, P¨¢l T##Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	"A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties##Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii##Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity"
DRAMP01350	FCTMIPIPRCY	11	"Tigerinin-1 (Frogs, amphibians, animals)"	P82651	Not found	Not found	Rana tigerina (Indian bull frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Bacillus subtilis (MIC=30 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=30 ?g/ml), Micrococcus luteus MT 166 (MIC=20 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=40 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=40 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=80 ?g/ml)."	[Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 ¦Ìg/ml against rat erythrocytes.	Cyclic	Free	Amidation	Disulfide bond between Cys2 and Cys10.	L	No cytotoxicity information found	Cell membrane	11031261	J Biol Chem. 2001 Jan 26;276(4):2701-2707. 	"Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N."	Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.
DRAMP01351	RVCFAIPLPICH	12	"Tigerinin-2 (Frogs, amphibians, animals)"	P82652	Not found	Not found	Rana tigerina (Indian bull frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Bacillus subtilis (MIC=20 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=40 ?g/ml), Micrococcus luteus MT 166 (MIC=20 ?g/ml).##Gram-negative bacteria: Pseudomonas putida NCIM 2102 (MIC=50 ?g/ml), Escherichia coli (MIC=50 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 ?g/ml)."	[Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 ¦Ìg/ml against rat erythrocytes.	Cyclic	Free	Amidation	Disulfide bond between Cys3 and Cys11.	L	No cytotoxicity information found	Cell membrane	11031261	J Biol Chem. 2001 Jan 26;276(4):2701-2707. 	"Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N."	Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.
DRAMP01352	RVCYAIPLPICY	12	"Tigerinin-3 (Frogs, amphibians, animals)"	P82653	Not found	Not found	Rana tigerina (Indian bull frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Bacillus subtilis (MIC=30 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=30 ?g/ml), Micrococcus luteus MT 166 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=40 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=40 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=80 ?g/ml)."	[Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 ¦Ìg/ml against rat erythrocytes.	Cyclic	Free	Amidation	Disulfide bond between Cys3 and Cys11.	L	No cytotoxicity information found	Cell membrane	11031261	J Biol Chem. 2001 Jan 26;276(4):2701-2707. 	"Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N."	Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.
DRAMP01353	RVCYAIPLPIC	11	"Tigerinin-4 (Frogs, amphibians, animals)"	P82654	Not found	Not found	Rana tigerina (Indian bull frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand-turn	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacterium: Staphylococcus aureus ATCC 8530 (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=60 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=60 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 ?g/ml)."	[Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 ¦Ìg/ml against rat erythrocytes.	Cyclic	Free	Amidation;Cyclization (Cys3 and Cys11)	Disulfide bond between Cys3 and Cys11.	L	No cytotoxicity information found	Cell membrane	11031261	J Biol Chem. 2001 Jan 26;276(4):2701-2707. 	"Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N."	Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.
DRAMP01355	FLGGLIKIVPAMICAVTKKC	20	"Ranalexin (Frogs, amphibians, animals)"	P39084	Not found	Not found	Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations.
Tissue specificity: Expressed by the skin dorsal glands.
Developmental stage: Expression starts at metamorphosis and continues into adulthood.
PTM: Contains one disulfide bond 14-20."	"Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=32 ?g/ml), Pseudomonas aeruginosa (MIC=128 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys14 and Cys20)	Disulfide bond between Cys14 and Cys20.	L	No cytotoxicity information found	Not found	8144672##9578480	J Biol Chem. 1994 Apr 8;269(14):10849-10855.##Eur J Biochem. 1998 Apr 1;253(1):221-228.	"Clark DP, Durell S, Maloy WL, Zasloff M.##Vignal E, Chavanieu A, Roch P, Chiche L, Grassy G, Calas B, Aumelas A."	"Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.##Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles."
DRAMP03024	LKLKSIVSWAKKVL	14	"Mastoparan B (MP-B; insects, arthropods, invertebrates, animals)"	P21654	Not found	Not found	Vespa basalis (Hornet)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti Mammalian cells, Anti-cancer"	Not found	Alpha helix	Tryptophan residue in MP	None	Function: Mast cell degranulating peptide. Activates G proteins that couple to phospholipase C. Has hemolytic activity.	"[Ref.10667861] Gram-positive bacteria: Staphylococcus epidermidis ATTC 12228 (MIC=25 ?M), Bacillus subtilis PCI 219 (MIC=25 ?M), Enterococcus faecium EFMY-28 (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli NIHJ JC-2 (MIC=50 ?M)"	"[Ref.10667861] 68.2% hemolysis at the peptide concentration of 100 ?M is , 27.9% Hemolysis at 50 ?M against human red blood cells."	Linear	Free	Amidation	Free	L	[Ref.10667861]No cytotoxicity information found##[Ref.8555423]No cytotoxicity information found	Not found	10667861##8555423	J Pept Res. 2000 Jan;55(1):51-62.##Biopolymers. 1995 Dec;36(6):793-801	"Yu K, Kang S, Park N, Shin J, Kim Y.##Park NG, Yamato Y, Lee S, Sugihara G1995"	Relationship between the tertiary structures of mastoparan B and its analogs and their lytic activities studied by NMR spectroscopy.##Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity
DRAMP01358	FLGGLFKLVPSVICAVTKKC	20	"Ranalexin-Vb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana virgatipes (Ranidae) (Aquarana)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys14 and Cys20)	Disulfide bond between Cys14 and Cys20.	L	No cytotoxicity information found	Not found	15996769	Regul Pept 2005; 131: 38-45.	Conlon JM et al Bevier CR.	"Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). "
DRAMP01359	FLGGLMKIIPAAFCAVTKKC	20	"Ranalexin-1G (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana grylio (North American pig frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	"Function: Has growth-inhibitory activity against the gram-positive bacterium Staphylococcus aureus, the gram-negative bacterium Escherichia coli and the yeast, Candida albicans."	Gram-negative bacterium: Escherichia coli (MIC=9 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=18 ?M).##Yeast: Candida albicans (MIC=70 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys14 and Cys20)	Disulfide bond between Cys14 and Cys20.	L	No cytotoxicity information found	Not found	10828493	Regul Pept. 2000 Jun 30;90(1-3):53-60.	"Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM."	Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio.
DRAMP01362	GLMSVLGHAVGNVLGGLFKS	20	"Frenatin-3 (Frogs, amphibians, animals)"	P56249	Not found	Not found	Litoria infrafrenata (Giant tree frog) (White-lipped tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Wide spectrum antimicrobial peptide. Considered to interact with the outer lipid layer of the bacterial cell, penetrate the bacterial membrane, form ion channels, and ultimately kill the cell.
Tissue specificity: Expressed by the skin parotoid and/or rostral glands."	"Gram-negative bacterium: Escherichia coli (MIC=50 ?g/ml);##Gram-positive bacteria: Leuconostoc mesenteroides (MIC=25 ?g/ml), Bacillus cereus (MIC=12.5 ?g/ml), Micrococcus luteus (MIC=1.5 ?g/ml), Pastewella haemolytica (MIC=0.8 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.9225251]No cytotoxicity information found	Not found	9225251	J Pept Sci. 1996 Mar-Apr;2(2):117-124.	"Raftery MJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ."	The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata.
DRAMP01364	GLFGVLAKVAAHVVPAIAEHF	21	"Maculatin-1.1 (Frogs, amphibians, animals)"	P82066	Not found	Not found	Litoria genimaculata (Green-eyed tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Protein level	Alpha helix	Not found	None	"Function: Maculatin-1.1 shows significant antibacterial activity against Gram-positive bacteria, less against Gram-negative bacteria.
Tissue specificity: Expressed by the skin dorsal glands.
PTM: C-terminal amidation."	"[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Bacillus cereus (MIC=3 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=3 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=11.3 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	No cytotoxicity information found in the reference(s) presented	Not found	16140737##9620615##15203252	J Virol. 2005 Sep;79(18):11598-606. ##J Pept Sci. 1998 Apr;4(2):111-115.##Peptides. 2004; 25: 1035-1054.	"VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. ##Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE."	"Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance."
DRAMP01370	MLCKLSMFGAVLGVPACAIDCLPMGKTGGSCEGGVCGCRKLTFKILWDKKFG	52	"Oh-defensin (O. hainana defensin; spiders, animals)"	No entry found	Not found	Not found	Ornithoctonus hainana (Venoms)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial and antifungal activities.	"Gram-positive bacteria: Staphylococcus aureus (MIC=1.25 ?g/ml), Bacillus cereus (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=1.25 ?g/ml), Bacillus dysenteriae (MIC=1.25 ?g/ml), Pseudomonas aeruginosa (MIC=5 ?g/ml).##Yeast: Candida albicans (MIC=1.25 ?g/ml)."	"[Ref.21538709] It has little hemolytic activity, inducing 7% hemolysis at the concentration up to 200 ?g/ml (about 36 ?M)."	Cyclic	Free	Free	Has three disulfide bonds	L	No cytotoxicity information found	Not found	21538709	J Pept Sci. 2011 Jul;17(7):540-544. 	"Zhao H, Kong Y, Wang H, Yan T, Feng F, Bian J, Yang Y, Yu H."	"A defensin-like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana."
DRAMP01371	GLLSGILGAGKHIVCGLTGCAKA	23	"Odorranain-NR (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Combine helix and strand structure	"Odorranain-NR has a large proportion of beta-sheet. In Tris HCl + SDS, odorranain-NR has a major conformation of beta-sheet (79.2%) and a minor conformation of beta-turn (1.3%). In Tris HCl, the beta-sheet has been decreased to 57.1% and the beta-turn has been increased to 10.5%. The beta-sheet has been decreased to 39.8% in water."	None	"Function: Odorranain-NR exhibits antimicrobial activity against the tested strains except E. coli ATCC25922. Odorranain-NR has little hemolytic activity on red blood cells even with peptide concentration up to 100 mg/ml.
PTM: Odorranain-NR has an intramolecular disulfide-bridged hexapeptide segment, which is a new type of disulfide-bridge motif in amphibian antimicrobial peptides."	"[Ref.18282640]Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=9.375 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 ?g/ml), Bacillus dysenteriae (MIC=37.5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=18.75 ?g/ml)."	[Ref:18282640] It has little hemolytic activity at 100 ¦Ìg/ml against rabbit red blood cells	Cyclic	Free	Free	Disulfide bond between Cys15 and Cys20.	L	No cytotoxicity information found	Not found	18282640	Peptides. 2008 Apr;29(4):529-535. 	Che Q et al Lai R.	A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami.
DRAMP00931	TCSYTMEA	8	Antimicrobial peptide 3 (Cn-AMP3; Plant defensin)	P86707	Not found	Not found	Cocos nucifera (Coconut palm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against Gram-negative and Gram-positive bacteria.
Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level).
Subunit structure: Monomer."	[Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=257 ¦Ìg/ml) and Staphylococcus aureus (MIC=274 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli (MIC=302 ¦Ìg/ml) and Pseudomonas aeruginosa (MIC=259 ¦Ìg/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.19111587]No cytotoxicity information found	Not found	19111587	Peptides. 2009 Apr;30(4):633-637.	"Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL."	Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water.
DRAMP00930	TESYFVFSVGM	11	Antimicrobial peptide 2 (Cn-AMP2; Plant defensin)	P86706	Not found	Not found	Cocos nucifera (Coconut palm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against Gram-negative and Gram-positive bacteria.
Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level).
Subunit structure: Monomer."	"[Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=150 ¦Ìg/ml), Staphylococcus aureus (MIC=170 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli (MIC=170 ¦Ìg/ml), Pseudomonas aeruginosa (MIC=169 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.19111587]No cytotoxicity information found	Not found	19111587	Peptides. 2009 Apr;30(4):633-637.	"Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL."	Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water.
DRAMP00929	SVAGRAQGM	9	Antimicrobial peptide 1 (Cn-AMP1; Plant defensin)	P86705	Not found	Not found	Cocos nucifera (Coconut palm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Helix	Not found	2N0V resolved by NMR.	"Function: Antibacterial activity against Gram-negative and Gram-positive bacteria.
Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level).
Subunit structure: Monomer."	"[Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=76 ¦Ìg/ml), Staphylococcus aureus (MIC=80 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli (MIC=82 ¦Ìg/ml), Pseudomonas aeruginosa (MIC=79 ¦Ìg/ml). "	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.19111587]No cytotoxicity information found	Not found	19111587	Peptides. 2009 Apr;30(4):633-637.	"Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL."	Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water.
DRAMP03542	HKTDSFVGLM	10	"Neurokinin A (NKA; chicken, animals)"	P19851	Belongs to the tachykinin family.	Not found	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Neuropeptide, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	1N6T resolved by NMR.	"Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Antibacterial activity is very low.
PTM: Methionine amide at position 10."	"[Ref.18603306] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>500 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>500 ¦Ìg/ml) ;## Gram-positive bacteria: Streptococcus mutans NCTC 10449 (MIC> 500 ¦Ìg/ml), Lactobacillus acidophilus NCTC 1723 (MIC>500 ¦Ìg/ml), Enterococcus faecalis NCTC 12697 (MIC>500 ¦Ìg/ml), Staphylococcus aureus ATCC 25923 (MIC>500 ¦Ìg/ml);## Yeast: Candida albicans NCTC 3179 (MIC>500 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.18603306]No cytotoxicity information found	Not found	18603306	J Neuroimmunol. 2008 Aug 30;200(1-2):11-16.	"El Karim IA, Linden GJ, Orr DF, Lundy FT."	"Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites."
DRAMP02344	KVHGSLARAGK	11	"40S ribosomal protein S30 (Fish, chordates, animals)"	P83328	Belongs to the eukaryotic ribosomal protein eS30 family.	fau	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and low activity against Gram-negative bacteria.	"[Ref.12147245] Gram-negetive bacteria: Escherichia coli (EC50>0.3 ¦ÌM, MBC>0.3 ¦ÌM), Listonella anguillarum (EC50>0.3 ¦ÌM, MBC>0.3 ¦ÌM) ;##Gram-positive bacteria: Bacillus subtilis (EC50=0.15¨C0.3 ¦ÌM, MBC>0.3 ¦ÌM), Planococcus citreus (EC50=0.02¨C0.04 ¦ÌM, MBC=0.08 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.12147245]No cytotoxicity information found	Not found	12147245	Biochem Biophys Res Commun. 2002 Aug 9;296(1):167-171.	"Fernandes JM, Smith VJ."	A novel antimicrobial function for a ribosomal peptide from rainbow trout skin.
DRAMP02993	YVPLPNVPQPGRRPFPTFPGQGPFNPKIKWPQGY	34	"Abaecin (Pro-rich; insects, arthropods, invertebrates, animals)"	P15450?	Not found	Not found	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Rich 	The prolines are in repeated motifs.	None	Function: This peptide has bactericidal activity.	"[Ref.2298215] Gram-negative bacteria: Agrobacterium tumefaciens Gembloux A (MIC=25-50 ?g/ml), Erwinia salicis NCPPB 2530 (MIC=25-50 ?g/ml), Escherichia coli NCTC 9001 (MIC=25-50 ?g/ml), Escherichia coli K514 (MIC=10-25 ?g/ml), Pseudomonas syringae pv.tomato NCPPB 1105 (MIC=25-50 ?g/ml), Xanthomonas campestris pv. vesicatoria LMG 905 (MIC=5-10 ?g/ml);##Gram-positive bacteria: Bacillus megateriurn QMB 1551 (MIC=10-25 ?g/ml), Micrococcus lysodeikticus LMG 4050 (MIC=10-25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.2298215]No cytotoxicity information found##[Ref.7961803]No cytotoxicity information found	Not found	2298215##7961803	Eur J Biochem. 1990 Jan 26;187(2):381-386.##J Biol Chem. 1994 Nov 18;269(46):28569-28575.	"Casteels P, Ampe C, Riviere L, Van Damme J, Elicone C, Fleming M, Jacobs F, Tempst P.##Casteels-Josson K, Zhang W, Capaci T, Casteels P, Tempst P."	"Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera).##Acute Transcriptional  Response of the Honeybee Peptide-Antibiotics Gene  Repertoire and Required Post-translational  Conversion of the Precursor Structures."
DRAMP02997	GNNRPVYIPQPRPPHPRL	18	"Apidaecin-1B (Apidaecin IB; Insects, animals)"	"P35581, Q06602, Q06601, Q8WSY8"	Belongs to the apidaecin family	Not found	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	4E81 resolved by X-ray.	Function: Apidaecins have bactericidal activity; predominantly against Gram-negative bacteria. They seem to interfere with cell propagation.	"[Ref.2676519] Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 ¦Ìg/ml), Erwinia salicis (MIC=0.02 ¦Ìg/ml), Escherichia coli (MIC=0.1 ¦Ìg/ml), Pseudomonas syringae (MIC=0.1 ¦Ìg/ml), Rhizobium meliloti (MIC=0.02 ¦Ìg/ml), Salmonella Newport (MIC=0.2 ¦Ìg/ml), Salmonella typhimurium (MIC=0.1 ¦Ìg/ml), Shigella flexneri (MIC=0.1 ¦Ìg/ml);##Gram-positive bacteria: Corynebacterium insidiosum (MIC=50 ¦Ìg/ml), Bacillus megaterium (MIC=100 ¦Ìg/ml).##[Ref.2298215] Gram-negative bacteria: Agrobacterium tumefaciens Gembloux A (MIC¡Ü1 ?g/ml), Erwinia salicis NCPPB 2530 (MIC¡Ü1 ?g/ml), Escherichia coli NCTC 9001 (MIC¡Ü1 ?g/ml), Escherichia coli K514 (MIC=25-50 ?g/ml), Pseudomonas syringae pv.tomato NCPPB 1105 (MIC¡Ü1 ?g/ml), Xanthomonas campestris pv. vesicatoria LMG 905 (MIC¡Ý100 ?g/ml);##Gram-positive bacteria: Bacillus megateriurn QMB 1551 (MIC=25-50 ?g/ml), Bacillus alvei LMG 6922 (MIC=50-100 ?g/ml),Micrococcus lysodeikticus LMG 4050 (MIC=25-50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.2298215]No cytotoxicity information found##[Ref.2676519]No cytotoxicity information found	Not found	2676519##2298215	EMBO J. 1989 Aug;8(8):2387-2391.##Eur J Biochem. 1990 Jan 26;187(2):381-386.	"Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P.##Casteels P, Ampe C, Riviere L, Van Damme J, Elicone C, Fleming M, Jacobs F, Tempst P."	"Apidaecins: antibacterial peptides from honeybees.##Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera)."
DRAMP02840	FKCRRWQWRMKKLGAPSITCVRRAF	25	"Lactoferricin B (Lfcin B; mammals, animals)"	"P24627, E6YCQ7, B3VTM3, B9VPZ5, C7FE01, Q6LBN7, Q19KS1"	Belongs to the transferrin family	LTF	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Beta strand (4 strands; 8 residues)	"Residues 7-9 form beta1 and residues 17-19 form beta2 (in membrane). This contrasts with X-ray structure where residues 1-13 is helical. Thus, this peptide appears to be able to adopt a different conformation depending on environmental conditions. disulfide bond is not required for the antimicrobial potency."	1LFC resolved by NMR.	"Function: Lactoferricin B  function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.
Activity regulation: Inhibited by PMSF and Pefabloc.
PTM: Contains one disulfide bond 3-20"	"[Ref.8980754] Gram-negative bacteria:  Escherichia coli L361 (MIC=4 ?M or 12.5 ?g/ml), Salmonella Salford (MIC=4 ?M or 12.5 ?g/ml), Escherichia coli O:9 (MIC=6 ?M or 18.8 ?g/ml), Pseudomonas ?uorescens (MIC=10 ?M or 31.3 ?g/ml)  ;##Gram-positive bacteria: Listeria monocytogenes (MIC=2 ?M or 6.3 ?g/ml), Staphylococcus aureus (MIC=6 ?M or 18.8 ?g/ml), Bacillus cereus (MIC=6 ?M or 18.8 ?g/ml)"	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys20.	L	No cytotoxicity information found	Not found	8980754##9521752##1490908 	"Antimicrob Agents Chemother. 1997 Jan;41(1):54-59. ##Biochemistry. 1998 Mar 24;37(12):4288-4298.##
J Appl Bacteriol. 1992 Dec;73(6):472-9."	"Hoek KS, Milne JM, Grieve PA, Dionysius DA, Smith R. ##Hwang PM, Zhou N, Shan X, Arrowsmith CH, Vogel HJ. ##Bellamy W, Takase M, Wakabayashi H, Kawase K, Tomita M.1992"	"Antibacterial activity in bovine lactoferrin-derived peptides. ##Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. ##
Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. "
DRAMP02244	GLFLDTLKGAAKDVAGKLLEGLKCKIAGCKP	31	"Ranatuerin-2Ca (Ranatuerin 2Ca; Frogs, amphibians, animals)"	P82878	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana clamitans (Green frog) (Lithobates clamitans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide has defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, male-specific defense response to bacterium, antibacterial humoral response, antibacterial humoral response,  induced systemic resistance, antifungal innate immune response, antifungal humoral response, defense response to fungus (incompatible interaction) in GO analysis.
Tissue specificity: Expressed by the skin glands.
PTM: Disulfide bond at position 24 and 29."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys24 and Cys29.	L	No cytotoxicity information found	Not found	10822101	Peptides. 2000 Apr;21(4):469-476.	"Halverson T, Basir YJ, Knoop FC, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
DRAMP01357	FLGGLMKAFPAIICAVTKKC	20	"Ranalexin-1Cb (Ranatuerin 1Cb; Frogs, amphibians, animals)"	P82877	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana clamitans (Green frog) (Lithobates clamitans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide has defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, male-specific defense response to bacterium, antibacterial humoral response, antibacterial humoral response,  induced systemic resistance, antifungal innate immune response, antifungal humoral response, defense response to fungus (incompatible interaction) in GO analysis.
Tissue specificity: Expressed by the skin glands."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys14 and Cys20)	Disulfide bond between Cys14 and Cys20.	L	No cytotoxicity information found	Not found	10822101	Peptides. 2000 Apr;21(4):469-476.	"Halverson T, Basir YJ, Knoop FC, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
DRAMP02246	SMLSVLKNLGKVGLGLVACKINKQC	25	"Ranatuerin-1C (Ranatuerin 1C; Frogs, amphibians, animals)"	P82875	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana clamitans (Green frog) (Lithobates clamitans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. 
Tissue specificity: Expressed by the skin glands."	[Ref.10822101] Gram-positive bacterium: Staphylococcus aureus (MIC=55 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=1.5 ¦ÌM).##Yeast: Candida albicans (MIC=58 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys19 and Cys25)	Disulfide bond between Cys19 and Cys25.	L	No cytotoxicity information found	Not found	10822101	Peptides. 2000 Apr;21(4):469-476.	"Halverson T, Basir YJ, Knoop FC, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
DRAMP01394	GLLRASSVWGRKYYVDLAGCAKA	23	"Odorranain-W2 (Frogs, amphibians, animals)"	A7YL71	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Shows antibacterial and antifungal activities.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?g/ml), Bacillus dysenteriae (MIC=30 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=20 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Free	Free	L	[Ref.17698252]No cytotoxicity information found	Not found	17698252	Peptides. 2007 Aug;28(8):1527-1531. 	"Chen L, Li Y, Li J, Xu X, Lai R, Zou Q."	An antimicrobial peptide with antimicrobial activity against Helicobacter pylori.
DRAMP01395	VVKCSYRLGSPDSQCN	16	"Odorranain-A-OA1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Weakly active against bacteria and fungi.	"[Ref.22029824]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=35.2 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=17.6 ?g/ml)."	[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Free	Disulfide bond between Cys4 and Cys15.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01396	GFMDTAKNVAKNMAGNLLDNLKCKITKAC	29	"Odorranain-F-OA1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=2.5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=2.5 ?g/ml)."	[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01397	GFMDTAKNVAKNMAVTLLDNLKCKITKAC	29	"Odorranain-F-OA2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Weakly active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.5 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.8 ?g/ml)."	[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01398	GFMDTAKNVAKNEAGNLLDNLKCKITKAC	29	"Odorranain-F-OA3 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Weakly active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml)£»##Yeast: Candida albicans ATCC 2002 (MIC=6.3 ?g/ml)."	[Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01399	GFMATAKNVAKNMDVTLLDNLKCKITKAC	29	"Odorranain-F-OA4 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Weakly active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/ml)£»##Yeast: Candida albicans ATCC 2002 (MIC=4.1 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01401	GFMNTAKNVAKNVAVTLLDNLKCKITGGC	29	"Odorranain-F-OW1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana wuchuanensis (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=2 ?M), Pseudomonas aeruginosa (MIC=4 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01402	GLFTLIKGAYKLDAPTVACN	20	"Odorranain-J-OA1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Weakly active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ?g/ml)£»##Yeast: Candida albicans ATCC 2002 (MIC=20.1 ?g/ml)."	[Ref:22029824]Not found	Linear	Free	Free	Free	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01403	GLFTLIKGAYKNDAPTVACN	20	"Odorranain-J-OA2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Weakly active against bacteria and fungi.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=20.1 ?g/ml)."	[Ref:22029824]Not found	Linear	Free	Free	Free	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01409	GILSGILGVGKKLVCGLSGLC	21	"Nigrocin-OR1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana rotodora (Chinese odorous frogs)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=4 ?M), Pseudomonas aeruginosa (MIC=7 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M).##Yeast: Candida albicans (MIC=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01410	GILSGILGVGKMLVCGLSGLC	21	"Nigrocin-OR2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana rotodora (Chinese odorous frogs)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Bacillus pyocyaneus CMCCB 10104 (MIC=5 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01411	GILSGLLGVGKMLVCGLSGLC	21	"Nigrocin-OR3 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana rotodora (Chinese odorous frogs)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Bacillus pyocyaneus CMCCB 10104 (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01412	GLLGSLFGAGKKVACALSGLC	21	"Nigrocin-2HSa (Frogs, amphibians, animals)"	P0C8U0	Not found	Not found	Odorrana hosii (Hose's rock frog) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. 
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 15-21."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=56 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=28 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01413	GLLGSIFGAGKKIACALSGLC	21	"Nigrocin-2HSb (Frogs, amphibians, animals)"	P0C8U1	Not found	Not found	Odorrana hosii (Hose's rock frog) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. 
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 15-21."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=28 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=14 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01414	GIFSTVFKAGKGIVCGLTGLC	21	"Nigrocin-2ISa (Frogs, amphibians, animals)"	F1T156	Not found	Not found	Odorrana ishikawae (Ishikawa's frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	[Ref.21193000]No cytotoxicity information found	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP01415	GILGTVFKAGKGIVCGLTGLC	21	"Nigrocin-2ISb (Frogs, amphibians, animals)"	F1T157	Not found	Not found	Odorrana ishikawae (Ishikawa's frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP01416	GILSTVFKAGKGIVCGLSGLC	21	"Nigrocin-2ISc (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana ishikawae (Ishikawa's frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 ?M).##Yeast: Candida albicans (MIC=100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	21867685	Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-677. 	"Iwakoshi-Ukena E, Soga M, Okada G, Fujii T, Sumida M, Ukena K."	Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning.
DRAMP01417	GLLSGILGAGKHIVCGLSGLC	21	"Nigrocin-2GRa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana grahami (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial against Gram-negative bacterium E. coli. Also has a weak hemolytic activity against human erythrocytes.	[Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=25 ?M).	[Ref:16621155] LC50=295 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	16621155	Peptides. 2006 Sep;27(9):2111-2117.	"Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H."	"Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami."
DRAMP01418	GLFGKILGVGKKVLCGLSGMC	21	"Nigrocin-2GRb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana grahami (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial against the Gram-negative bacterium E. coli and the Gram-positive bacterium S. aureus. Also has a weak hemolytic activity against human erythrocytes.	[Ref.16621155]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Yeast: Candida albicans (MIC=50 ?M).	[Ref:16621155] LC50=40 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	16621155	Peptides. 2006 Sep;27(9):2111-2117.	"Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H."	"Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami."
DRAMP01419	GLLSGILGAGKNIVCGLSGLC	21	"Nigrocin-2GRc (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana grahami (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial against Gram-negative bacterium E. coli. Also has a weak hemolytic activity against human erythrocytes.	[Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=50 ?M).	[Ref:16621155] LC50>500 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	16621155	Peptides. 2006 Sep;27(9):2111-2117.	"Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H."	"Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami."
DRAMP01420	GLLSGILGAGKHIICGLSGLC	21	"Nigrocin-OG4 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-negative bacterium: Escherichia coli (MIC>100 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?g/ml), Bacillus subtilis (MIC>100 ?g/ml).##Yeast: Candida albicans (MIC=1.10 ?g/ml)."	"[Ref.17272268] RCH=65.5 ¡À 7.7% against rabbit red blood cells at 50 ¦Ìg/ml. RCH, red cell hemolysis."	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01421	GLLSGILGAGKQKVCGLSGLC	21	"Nigrocin-OG5 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-negative bacterium: Escherichia coli (MIC=9.37 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=18.75 ?g/ml), Bacillus subtilis (MIC=37.50 ?g/ml).##Yeast: Candida albicans (MIC=4.68 ?g/ml)."	"[Ref.17272268] RCH=87.2 ¡À 2.6% against rabbit red blood cells at 50 ¦Ìg/ml. RCH, red cell hemolysis."	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01422	GLLSGVLGVGKKVLCGLSGLC	21	"Nigrosin-OG21 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-negative bacterium: Escherichia coli (MIC=4.68 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml).##Yeast: Candida albicans (MIC=4.68 ?g/ml)."	"[Ref.17272268] RCH=100% against rabbit red blood cells at 50 ¦Ìg/ml. RCH, red cell hemolysis."	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01423	GLLSGILGAGKHIVCGLSGLR	21	"Nigrosin-OG13 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana grahami (Yunnanfu frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-negative bacterium: Escherichia coli (MIC=4.68 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml).##Yeast: Candida albicans (MIC=1.10 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.17272268]No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01426	GLLSGVLGVGKKIVCGLSGLC	21	"Nigrocin-1-OA1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=5.2 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01427	GIFGKILGVGKKTLCELSGMC	21	"Nigrocin-1-OA2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.3 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.2 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01428	GIFLKVLGVGKKVLCGVSGLC	21	"Nigrocin-1-OA3 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=10.8 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01429	GLISGILGVGKKLVCGLSGLC	21	"Nigrocin-1-OR1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=11.5 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01430	GLISGILGVGKMLVCGLSGLC	21	"Nigrocin-1-OR2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=8.6 ?g/ml)"	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01431	GLISGLLGVGKMLVCGLSGLC	21	"Nigrocin-1-OR3 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=10.2 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01432	GILGNIVGMGKKIVCGLSGLC	21	"Nigrocin-1-OW2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.2 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.1 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01433	GILGNIVGMGKKVVCGLSGLC	21	"Nigrocin-1-OW3 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=6.7 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01434	GILSGVLGMGKKIVCGLRGLC	21	"Nigrocin-1-OW4 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=14.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=7.2 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01435	GILGNIVGMGKQVVCGLSGLC	21	"Nigrocin-1-OW5 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=5.1 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01436	GILSGVLGMGKKIVCGLSGLC	21	"Nigrocin-1-OW1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=4.4 ?g/ml)."	[Ref:22029824] Not found in the literature	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
DRAMP01438	GIFGKILGAGKKVLCGLSGLC	21	"Nigrocin-2JDa (Frogs, amphibians, animals)"	B3A0M6	Not found	Not found	Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity against rabbit erythrocytes. 
PTM: contains one disulfide bond 15-21. "	"[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Staphylococcus aureus CIB 85462 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=16 ?M), Escherichia coli CIB 84492 (MIC=16 ?M);##Yeast: Candida albicans (MIC=63 ?M)."	[Ref:22917879] It has 80.3 ¡À 5.5% hemolytic activity at 128 ¦Ìg/ml against rabbit red blood cells	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22917879	J Proteomics. 2012 Oct 22;75(18):5807-5821.	"Liu J, Jiang J, Wu Z, Xie F."	"Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data."
DRAMP01439	GIFGKILGVGKKVLCGLSGMC	21	"Nigrocin-2JDb (Odorranain-H2; Frogs, amphibians, animals)"	B3A0M7	Not found	Not found	Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity against rabbit erythrocytes.
PTM: contains one disulfide bond 15-21. "	"[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15 ?M), Staphylococcus aureus CIB 85462 (MIC=15 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=8 ?M), Escherichia coli CIB 84492 (MIC=8 ?M);##Yeast: Candida albicans (MIC=31 ?M)."	[Ref:22917879] It has 88.4 ¡À 4.2% hemolytic activity at 128 ¦Ìg/ml against rabbit red blood cells	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	22917879	J Proteomics. 2012 Oct 22;75(18):5807-5821.	"Liu J, Jiang J, Wu Z, Xie F."	"Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data."
DRAMP01440	GILSGILGMGKKLVCGLSGLC	21	"Nigrocin-2LVb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana livida (Chinese Odorrana frogs)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. 	Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	20158520	FEBS J. 2010 Mar;277(6):1519-1531.	"Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C."	Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis.
DRAMP01441	SILSGNFGVGKKIVCGLSGLC	21	"Nigrocin-2VB (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana livida (Chinese Odorrana frogs)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacterium E. coli. 	Gram-negative bacterium: Escherichia coli (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	20158520	FEBS J. 2010 Mar;277(6):1519-1531.	"Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C."	Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis.
DRAMP01442	GILSGILGAGKSLVCGLSGLC	21	"Nigrocin-2SCa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana schmackeri (Chinese Odorrana frogs)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacterium E. coli. 	Gram-negative bacterium: Escherichia coli (MIC=50 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	20158520	FEBS J. 2010 Mar;277(6):1519-1531.	"Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C."	Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis.
DRAMP01443	GILSNVLGMGKKIVCGLSGLC	21	"Nigrocin-2SCc (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana schmackeri (Chinese Odorrana frogs)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacterium E. coli. 	Gram-negative bacterium: Escherichia coli (MIC=70 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Not found	20158520	FEBS J. 2010 Mar;277(6):1519-1531.	"Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C."	Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis.
DRAMP01447	GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC	37	"Esculentin-2CHa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Lithobates chiricahuensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: E. coli (MIC=5 ?M), K. pneumoniae (MIC=5 ?M), P. aeruginosa (MIC=5 ?M);##Gram-positive bacterium: S. aureus (MIC=5 ?M).##Yeast: C. albicans (MIC=10 ?M)."	[Ref.21262304] LC50=150 ?M against human erythrocytes	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	21262304	Peptides. 2011 Apr;32(4):664-669.	"Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD."	Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona.
DRAMP01452	RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC	47	"Esculentin-1LTa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylarana latouchii (Broad-folded frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=0.6 ?M), Bacillus licheniformis X39 (MIC=10 ?M), Staphylococcus carnosus KHS (MIC=1.3 ?M), Rhodococcus rhodochrous X15 (MIC=0.3 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?M), Serratia rubidaea X01 (MIC=10 ?M), Psychrobacter faecalis X29 (MIC=0.6 ?M).##Yeast: Candida albicans ATCC2002 (MIC=80 ?M)."	[Ref.22426384] LD50>480 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys41 and Cys47)	Disulfide bond between Cys41 and Cys47.	L	No cytotoxicity information found	Not found	22426384	Biochimie. 2012 Jun;94(6):1317-1326.	"Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J."	"Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii."
DRAMP01453	GIFSLFKAGAKFFGKHLLKQAGKAGAEHLACKATNQC	37	"Esculentin-2LTa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylarana latouchii (Broad-folded frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.6 ?M), Bacillus licheniformis X39 (MIC=3.2 ?M), Staphylococcus carnosus KHS (MIC=3.2 ?M), Rhodococcus rhodochrous X15 (MIC=0.8 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=1.6 ?M). "	[Ref.22426384] LD50>600 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	22426384	Biochimie. 2012 Jun;94(6):1317-1326.	"Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J."	"Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii."
DRAMP01454	GLFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC	37	"Esculentin-2JDa (Frogs, amphibians, animals)"	B3A0M8	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against E. coli and S. aureus strains (Probable).
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 31-37."	"Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=34 ?g/ml), Extended-spectrum ??-lactamases E. coli (ESBL) (MIC=34 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (ATCC 25923) (MIC=8 ?g/ml), Methicillin-resistant S. aureus (MRSA) (MIC=8 ?g/ml). "	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	22917879	J Proteomics. 2012 Oct 22;75(18):5807-5821.	"Liu J, Jiang J, Wu Z, Xie F."	"Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: de novo sequencing and analysis of tandem mass spectrometry data."
DRAMP01456	GLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC	37	"Esculentin-2PLa (Frogs, amphibians, animals)"	"A7WNV5, D3UA57"	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-negative bacterium E. coli, the Gram-positive bacterium: S. aureus and the yeast C. albicans.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 31-37."	Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=10 ?M).##Yeast: Candida albicans (MIC=49 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01457	GIFSKFAGKGIKDLIIKGVKGIAKEAGMDVIRTGIDIAGCKIKGEC	46	"Esculentin-1V (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hainanensis (Chinese frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli.	Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=4.9 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.2 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	16427248	Genomics. 2006 May;87(5):638-644.	"Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C."	Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs.
DRAMP01458	GIFTLFKGAAKLLGKTLAKEAGKTGLELMACKVTNQC	37	"Esculentin-2V (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hainanensis (Chinese frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli.	Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=4.4 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.8 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	16427248	Genomics. 2006 May;87(5):638-644.	"Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C."	Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs.
DRAMP01461	GLFSKFAGKGIKNMIIKGIKGIGKEVGMDVIRTGIDVAGCKIKGEC	46	"Esculentin-1S (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana schmackeri (piebald odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli.	Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.7 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	16427248	Genomics. 2006 May;87(5):638-644.	"Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C."	Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs.
DRAMP01462	GLFTLIKGAVKMIGKTVAKEAGKTGLELMACKVTNQC	37	"Esculentin-2S (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana schmackeri (piebald odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli.	Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=2.6 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.1 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	16427248	Genomics. 2006 May;87(5):638-644.	"Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C."	Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs.
DRAMP01469	GIFALIKTAAKFVGKNLLKQAGKAGLEHLACKANNQC	37	"Esculentin-2-Ala (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Esculentin-2-Ala exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus dysenteriae (MIC=7.5 ?g/mL), Bacillus cereus (MIC=7.5 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=12.5 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Acinetobacter calcoaceticus (MIC=25 ?g/mL), Psecdomonas aeruginosa (MIC=50 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)"	[Ref:19843479] It has 22% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloen."
DRAMP01470	GIFSLIKTAAKFVGKNLLKQAGKAGVEHLACKANNQC	37	"Esculentin-2-ALb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Esculentin-2-Alb exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=7.5 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=12.5 ?g/mL), Bacillus dysenteriae (MIC=7.5 ?g/mL), Acinetobacter calcoaceticus (MIC=12.5 ?g/mL), Psecdomonas aeruginosa (MIC=50 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)."	[Ref:19843479] It has 17% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloen."
DRAMP01471	GLFPKINKKKAKTGVFNIIKTVGKEAGMDLIRTGIDTIGCKIKGEC	46	"Esculentin-1PLa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (North American pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli.	Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01472	GIFTKINKKKAKTGVFNIIKTIGKEAGMDVIRAGIDTISCKIKGEC	46	"Esculentin-1PLb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (North American pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli.	Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01474	GIFSKINKKKAKTGLFNIIKTVGKEAGMDVIRAGIDTISCKIKGEC	46	"Esculentin-1ARa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana areolata (crawfish frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Esculentin-1ARa has antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Also exhibits hemolytic activity against human erythrocytes (HC50=180 ?M).	[Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=13 ?M).	[Ref:12429503] HC50=180 ?M against human erythrocytes	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	12429503	Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63.	"Ali MF, Lips KR, Knoop FC, Fritzsch B, Miller C, Conlon JM."	"Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata."
DRAMP01475	GLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC	46	"Esculentin-1ARb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana areolata (crawfish frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Esculentin-1ARb has antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Also exhibits hemolytic activity against human erythrocytes (HC50=120 ?M).	[Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M).	[Ref:12429503] HC50=120 ?M against human erythrocytes	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	12429503	Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63.	"Ali MF, Lips KR, Knoop FC, Fritzsch B, Miller C, Conlon JM."	"Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata."
DRAMP01476	GIFSLIKGAAQLIGKTVAKEAGKTGLELMACKVTKQC	37	"Esculentin-2HSa (Frogs, amphibians, animals)"	P0C8T9	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hosii (Hose's rock frog) (Rana hosii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 31-37."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=32 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=16 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01477	GIFSKFGGKAIKNLFIKGAKNIGKEVGMDVIRTGIDVAGCKIKGEC	46	"Esculentin-1HSa (Frogs, amphibians, animals)"	P0C8T8	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana hosii (Hose's rock frog) (Odorrana hosii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 40-46."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=12 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01479	GLFSKLNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC	46	"Esculentin-1CPa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates capito (North American New World frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Active against bacteria and fungi.	[Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Yeast: Candida albicans (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	19635516	Peptides. 2009 Oct;30(10):1775-1781.	"Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD."	Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae).
DRAMP01480	GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC	37	"Esculentin-2CPa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates capito (North American New World frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Active against bacteria and fungi.	[Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Yeast: Candida albicans (MIC=25 ?M)	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	19635516	Peptides. 2009 Oct;30(10):1775-1781.	"Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD."	Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae).
DRAMP01482	GIFSKFAGKGIKNLLVKGVKNIGKEVGMDVIRTGIDIAGCKIKGEC	46	"Esculentin-1ISa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana ishikawae (Japanese Endangered frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows antibacterial activity.	"Gram-negative bacterium: Escherichia coli (MC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=25 ?M), Bacillus subtilis (MIC=25 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP01483	RIFSKIGGKAIKNLILKGIKNIGKEVGMDVIRTGIDVAGCKIKGEC	46	"Esculentin-1ISb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana ishikawae (Japanese Endangered frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity.	"Gram-negative bacterium: Escherichia coli (MC=3.1 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP01484	GIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC	37	"Esculentin-2ISa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana ishikawae (Japanese Endangered frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity.	"Gram-negative bacterium: Escherichia coli (MC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=25 ?M), Bacillus subtilis (MIC=6.3 ?M).##Yeast: Candida albicans (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP01486	GLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC	46	"Esculentin-1GRa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana grahami (Odorrana andersonii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Shows antibacterial activity, also activity against fungus C. albicans."	Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M).##Yeast: Candida albicans (MIC>50 ?M).	[Ref.16621155] LC50=210 ¦ÌM against human erythrocytes. 	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	16621155	Peptides 2006; 27: 2111-2117.	"Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H."	"Antimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami."
DRAMP01490	GILSLVKGVAKLAGKGLAKEGGKFGLELIACKIAKQC	37	"Esculentin-2A (Frogs, amphibians, animals)"	P40845	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (European Edible frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species.	"[Ref.8163497]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=0.8 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.4 ?M), Pseudomonas aeruginosa ATCC15692 (MIC=3.5 ?M)."	[Ref:8163497] Not found in the literature	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01491	GIFSKLAGKKLKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC	46	"Esculentin-1B (Frogs, amphibians, animals)"	P40844	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (European Edible frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.2 ?M), Pseudomonas aeruginosa ATCC15692 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.1 ?M), Staphylococcus aureus cowan I (MIC=0.4 ?M).##Fungi: Candida albicans (MIC=0.5 ?M), Saccharomyces cerevisiae (MIC=0.9 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.8163497]No cytotoxicity information found	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01493	GLFSKFVGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC	46	"Esculentin-1-OA1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=1.2 ?g/mL), Staphylococcus aureus ATCC 25923 (MIC=1.2 ?g/mL).##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.4 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01494	GLFSKFSGKGIKNFLIKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC	46	"Esculentin-1-OA2 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 ?g/mL);##Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=2.5 ?g/mL), Staphylococcus aureus ATCC 25923 (MIC=1.3 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.3 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01495	GLFSKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC	46	"Esculentin-1-OA3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.4 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.4 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.7 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01496	GLFTKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC	46	"Esculentin-1-OA4 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2.8 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.8 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=5.6 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01497	GLFSKFAGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC	46	"Esculentin-1-OA5 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.4 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1.7 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.4 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.7 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01499	GIFSKISGKAIKNLFIKGAKNVGKEVGMDVVRTGIDVVGCKIKGEC	46	"Esculentin-1-OR1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.4 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01501	GIFSKISGKAIKNLFIKGAKNVGKRVGMDVVRTGMDVVGCKIKGEC	46	"Esculentin-1-OR3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.5 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=11 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=11 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01502	GIFSKISGKAIKNLFIKGAENVGKHVGIDVVRTGIDVVGCKIKGEC	46	"Esculentin-1-OR4 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.6 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01503	GIFSKISGKAIKNLFIKGAKNVGKEVGIDVVRTGMDVVGCKIKGEC	46	"Esculentin-1-OR5 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=4.1 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.1 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01504	GIFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC	37	"Esculentin-2-OA1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.5 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.3 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=4.3 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.5 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01505	GLFTLIKGAAKLIGKTTAKEAGKTGKLEMACKITNQC	37	"Esculentin-2-OA2 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01507	GVFTLIKGATQLIGKTLGKELGKTGLELMACKITNQC	37	"Esculentin-2-OR1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=10.8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01508	GVFTLIKGATQLIGKTLGKEVGKTGLELMACKITKQC	37	"Esculentin-2-OR2 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.1 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=16.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.1 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01509	GVFTLLKGATQLIGKTLGKELGKTGLELMACKITNQC	37	"Esculentin-2-OR3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=7.9 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.9 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=15.8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01510	GVFTLIKGATQLIGKTLGKELGKTGLELMACKITEQC	37	"Esculentin-2-OR4 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=3.6 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01511	GVFTLIKGATQLIGKTLGKELGKTGLEIMACKITKQC	37	"Esculentin-2-OR5 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=15.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15.8 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=7.9 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	[Ref.22029824]No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01513	GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC	46	"Esculentin-1 (Frogs, amphibians, animals)"	P32414	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans.  Has hemolytic activity.	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.2 ?M), Pseudomonas aeruginosaATCC15692 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.1 ?M), Staphylococcus aureus Cowan1 (MIC=0.4 ?M).##Fungi: Candida albicans (MIC=0.5 ?M), Saccharomyces cerevisiae (MIC=0.9 ?M)."	[Ref. 8163497] LC>100¦ÌM	Cyclic	Free	Cyclization (Cys40 and Cys46)	Disulfide bond between Cys40 and Cys46.	L	[Ref.8508915]No cytotoxicity information found	Not found	8508915	FEBS Lett. 1993 Jun 14;324(2):159-161.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta.
DRAMP01520	GLLNTFKDWAISIAKGAGKGVLTTLSCKLDKSC	33	"Rugosin-A (Frogs, amphibians, animals)"	P80954	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Glandirana rugosa (Japanese wrinkled frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against Gram-positive bacteria.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 27-33."	"Gram-positive bacteria: Staphylococcus aureus 209P (MIC=6.25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=12.5 ?g/ml), Micrococcus luteus ATCC9341 (MIC=25 ?g/ml), Streptococcus pyogenes COOK (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli NIHJ (MIC=100 ?g/ml), Pseudomonas aeruginosa PAO-1 (MIC>100 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	[Ref.7612013]No cytotoxicity information found	Not found	7612013	Biochem Biophys Res Commun. 1995 Jul 6;212(1):249-254.	"Suzuki S, Ohe Y, Kagegawa T, Tatemoto K."	"Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa."
DRAMP01521	SLFSLIKAGAKFLGKNLLKQGAQYAACKVSKEC	33	"Rugosin-B (Frogs, amphibians, animals)"	P80955	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against both Gram-negative and Gram-positive bacteria.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 27-33."	"Gram-positive bacteria: Staphylococcus aureus 209P (MIC=6.25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=6.25 ?g/ml), Micrococcus luteus ATCC9341 (MIC=1.56 ?g/ml), Streptococcus pyogenes COOK (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli NIHJ (MIC=12.5 ?g/ml), Pseudomonas aeruginosa PAO-1 (MIC=100 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	[Ref.7612013]No cytotoxicity information found	Not found	7612013	Biochem Biophys Res Commun. 1995 Jul 6;212(1):249-254.	"Suzuki S, Ohe Y, Kagegawa T, Tatemoto K."	"Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa."
DRAMP01524	SIRDKIKTIAIDLAKSAGTGVLKTLICKLDKSC	33	"Rugosin-RN1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana nigrovittata	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has weak hemolytic activity gainst rabbit red cells.	"[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.69 ?g/ml), Bacillus subtilis (MIC=9.38 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=5.63 ?g/ml)"	[Ref:19778602]Show weak hemolytic activity against rabbit red cells	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bridge between Cys27 and Cys33.	L	[Ref.19778602]No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71.	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP01525	SIRDKIKTIAIDLAKSAGMGILKTLICKLDKSC	33	"Rugosin-RN3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana nigrovittata	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=16.51 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=15.00 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bridge between Cys27 and Cys33.	L	[Ref.19778602]No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71.	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP01526	SIRDKIKTIAIDLAKSAGTGVLKTLICKLNKSC	33	"Rugosin-RN5 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana nigrovittata	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=15.00 ?g/ml), Staphylococcus aureus ATCC43300 (MRSA) (MIC=12.50 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=18.75 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bridge between Cys27 and Cys33.	L	[Ref.19778602]No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71.	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP01533	CVISAGWNHKIRCKLTGNC	19	"Nigroain-B1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana nigrovittata (Black-striped frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Bridge	Not found	None	PTM: Contains one disulfide bridge.	"Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.69 ?g/ml), S. aureus ATCC43300 (MIC=50.00 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa PA01 (MIC=25.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25.00 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys13 and Cys19)	Disulfide bridge between Cys13 and Cys19.	L	[Ref.19778602]No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71. 	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP01539	FKTWKRPPFQTSCWGIIKE	19	"Nigroain-C2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana nigrovittata (Black-striped frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=27.50 ?g/ml), S. aureus ATCC43300 (MIC=55.00 ?g/ml), Bacillus subtilis (MIC=110.00 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=110.00 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=55.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=55.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=13.75 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.19778602]No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71. 	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP01546	SLWETIKNAGKGFIQNLDKIR	21	"Nigroain-K1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana nigrovittata (Black-striped frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. Also has hemolytic activity against rabbit red cells.	"[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=21.88 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=32.74 ?g/ml)."	[Ref:19778602]22.49 ¡À 4.8% hemolytic activity at 100 ?g/ml against rabbit red cells	Linear	Free	Free	Free	L	[Ref.19778602]No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71. 	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP01549	GLLSVLGSVAKHVLPHVVPVIAEHL	25	"Caerin-1.1 (Frogs, amphibians, animals)"	"P62568, P62569, Q800R2, P56226"	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria splendida (Magnificent tree frog) (Litoria gilleni) (Litoria caerulea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Protein level	Alpha helix 	The peptide adopts two well-defined helices from Leu2 to Lys11 and from Val17 to His24 separated by a region of less-defined helicity and greater flexibility.	None	"Function: Antibacterial and antiviral peptides that adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Secreted by the skin parotoid and/or rostral glands.
Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility.
Miscellaneous: Caerin 1.1 completely inhibits HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606).
PTM: C-terminal amidation."	"[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=1.5 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12.5 ?g/ml), Staphylococcus aureus (MIC=3-12 ?g/ml), Staphylococcus epidermis (MIC=12.5 ?g/ml), Streptococcus uberis (MIC=12.5 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml).##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=7.8 ¦ÌM);inhibition of HIV transfer by dendritic cells to T cells(IC50=12.6 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	No cytotoxicity information found in the reference(s) presented	Cell membrane	16140737##9266696##12709067##15203252	J Virol. 2005 Sep;79(18):11598-606. ##Eur J Biochem. 1997 Jul 15;247(2):545-557.##Eur J Biochem. 2003 May;270(9):2068-2081.##Peptides. 2004 Jun;25(6):1035-1054.	"VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Wong H, Bowie JH, Carver JA.##Vanhoye D, Bruston F, Nicolas P, Amiche M.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE."	"Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.##Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance."
DRAMP01550	GLLGAMFKVASKVLPHVVPAITEHF	25	"Caerin-1.11 (Frogs, amphibians, animals)"	Q800R9	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria caerulea (Green tree frog) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	"Function: Antibacterial and antiviral peptides that adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity (By similarity).
PTM: C-terminal amidation."	"Gram-negative bacteria: Escherichia coli B (MIC=25 ?M), Enterobacter cloacae (MIC=50 ?M), Klebsiella pneumoniae (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus haemolyticus (MIC=50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.12709067]No cytotoxicity information found##[Ref.22771617]No cytotoxicity information found	Not found	12709067##22771617	Eur J Biochem. 2003 May;270(9):2068-2081.##Peptides. 2012 Sep;37(1):174-188.	"Vanhoye D, Bruston F, Nicolas P, Amiche M.##Bowie JH, Separovic F, Tyler MJ."	"Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Host-defense peptides of Australian anurans. Part 2. Structure, activity, mechanism of action, and evolutionary significance."
DRAMP01552	GLLSVLGSVAQHVLPHVVPVIAEHL	25	"Caerin-1.3 (Frogs, amphibians, animals)"	P56228	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria caerulea (Australian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Expressed by the skin parotoid and/or rostral glands.
Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity).
PTM: C-terminal amidation."	"Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Staphylococcus aureus (MIC=6-12 ?g/ml), Staphylococcus epidermis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). (Ref.2)"	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.15203252]No cytotoxicity information found	Not found	15203252##PubMed ID is not available	Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936.	"Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ."	"Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula."
DRAMP01553	GLLSSLSSVAKHVLPHVVPVIAEHL	25	"Caerin-1.4 (Frogs, amphibians, animals)"	"P62544, P56229, P62545, P56229"	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria caerulea (Green tree frog) (also Litoria gilleni) (Centralian tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Expressed by the skin parotoid and/or rostral glands.
Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity).
PTM: C-terminal amidation."	"Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=0.4 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=100 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=50 ?g/ml), Pasteurella multocida (MIC=25 ?g/ml). (Ref.2)"	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.15203252]No cytotoxicity information found	Not found	15203252##PubMed ID is not available	Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936.	"Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ."	"Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula."
DRAMP01555	GLLSVLGSVVKHVIPHVVPVIAEHL	25	"Caerin-1.5 (Frogs, amphibians, animals)"	P56230	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria caerulea (Green tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Expressed by the skin parotoid and/or rostral glands.
Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity).
PTM: C-terminal amidation."	"[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). ##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 12.5 ?M.	Not found	26026377##15203252##PubMed ID is not available	Peptides. 2015 Sep;71:296-303. ##Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936.	"VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ."	"Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula."
DRAMP01560	GLFGVLGSIAKHVLPHVVPVIAEKL	25	"Caerin-1.9 (Frogs, amphibians, animals)"	P81252	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria chloris (Blue-thighed frog) (frog skin active peptide family)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Expressed by the skin dorsal glands.
Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity).
PTM: C-terminal amidation.
Miscellaneous: Caerin 1.9 completely inhibited HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606)."	"[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=50 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=1.2 ¦ÌM);inhibition of HIV transfer by dendritic cells to T cells(IC50=1.6 ¦ÌM).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	"[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 20	?M."	Not found	26026377##16140737##15203252##9516047	Peptides. 2015 Sep;71:296-303. ##J Virol. 2005 Sep;79(18):11598-606. ##Peptides. 2004 Jun;25(6):1035-1054.##J Pept Res. 1998 Feb;51(2):121-126.	"VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ."	"Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria."
DRAMP01562	GLVSSIGRALGGLLADVVKSKGQPA	25	"Caerin-2.1 (Frogs, amphibians, animals)"	"P56233, P86485"	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria splendida (Magnificent tree frog) (Emerald spotted tree frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Expressed by the skin parotoid and/or rostral glands."	Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). (Ref.2)	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.15203252]No  cytotoxicity information found##[Ref.19642086]No  cytotoxicity information found	Not found	15203252##19642086	Peptides. 2004 Jun;25(6):1035-1054.##Rapid Commun Mass Spectrom. 2009 Sep;23(17):2628-2636.	"Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Bilusich D, Jackway RJ, Musgrave IF, Tyler MJ, Bowie JH."	"Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##The host-defence skin peptide profiles of Peron's Tree Frog Litoria peronii in winter and summer. Sequence determination by electrospray mass spectrometry and activities of the peptides."
DRAMP01563	GLVSSIGRALGGLLADVVKSKEQPA	25	"Caerin-2.2 (Frogs, amphibians, animals)"	"P62570, P62571, P56234"	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria gilleni (Centralian tree frog) (also Litoria caerulea) (Green tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Expressed by the skin parotoid and/or rostral glands."	Gram-positive bacterium: Micrococcus luteus (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.15203252]No cytotoxicity information found	Not found	15203252##PubMed ID is not available	Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936.	"Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ."	"Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula."
DRAMP01574	GLWQKIKSAAGDLASGIVEGIKS	23	"Caerin-4.1 (Frogs, amphibians, animals)"	P56242	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria caerulea (Green tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral"	Protein level	Alpha helix 	Not found	None	"PTM: adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Expressed by the skin parotoid and/or rostral glands."	[Ref.15203252]Gram-positive bacterium: Micrococcus luteus (MIC=12 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=25 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.15203252]No cytotoxicity information found	Not found	15203252##PubMed ID is not available	Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936.	"Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ."	"Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula."
DRAMP01576	GLWQKIKNAAGDLASGIVEGIKS	23	"Caerin-4.3 (Frogs, amphibians, animals)"	P56244	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria caerulea (Green tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity: Expressed by the skin parotoid and/or rostral glands.
PTM: C-terminal amidation."	Gram-positive bacterium: Micrococcus luteus (MIC=25 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=50 ?g/ml).(Ref.2)	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.15203252]No cytotoxicity information found	Not found	15203252##PubMed ID is not available	Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936.	"Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ."	"Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula."
DRAMP01577	GLLSVLGSVAKHVLPHVVPVIAEKL	25	"Caerin-1.10 (Frogs, amphibians, animals)"	"P86502, P82104"	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria rothii (Roth's tree frog); also Litoria splendida (Magnificent tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide with wide spectrum of activity.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"[Ref.10601876]Gram-positive bacteria: Leuconostoc lactis (MIC=6 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml), Staphylococcus epidermidis (MIC=100 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=100 ?g/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	"[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 22	?M."	Not found	26026377##16124032##10601876	Peptides. 2015 Sep;71:296-303. ##Rapid Commun Mass Spectrom. 2005;19(18):2716-2724.##Eur J Biochem. 2000 Jan;267(1):269-275.	"VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Brinkworth CS, Bowie JH, Bilusich D, Tyler MJ.##Wabnitz PA, Bowie JH, Tyler MJ, Wallace JC, Smith BP."	"Inhibition of HIV infection by caerin 1 antimicrobial peptides.##The rothein peptides from the skin secretion of Roth's tree frog Litoria rothii. Sequence determination using positive and negative ion electrospray mass spectrometry.##Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10."
DRAMP01585	GLFSVLGSVAKHLLPHVVPVIAEKL	25	"Caerin-1.18 (Frogs, amphibians, animals)"	P0C2A7	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria gracilenta (Dainty green tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms.
Tissue specificity: Expressed by the skin dorsal glands.
PTM: C-terminal amidation."	"Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=25 ?g/ml), Listeria innocua (MIC=12 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus ATCC 25923 (MIC=12 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=25 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacteria: Pasteurella multocida (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.16554081]No cytotoxicity information found	Not found	16554081	Toxicon. 2006 May;47(6):664-675.	"Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ."	New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry.
DRAMP01586	GLFKVLGSVAKHLLPHVAPIIAEKL	25	"Caerin-1.19 (Frogs, amphibians, animals)"	P0C2A8	Belongs to the frog skin active peptide family (Caerin subfamily)	Not found	Litoria gracilenta (Dainty green tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral"	Protein level	Not found	Not found	None	"Function: Caerin-1.19 shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms.
Tissue specificity: Expressed by the skin dorsal glands.
PTM: C-terminal amidation."	"[Ref.16554081]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=12 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Staphylococcus aureus Strain ATCC 25923 (MIC=12 ?g/ml), Staphylococcus aureus Strain ATCC 29213 (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacteria: Pasteurella multocida (MIC=50 ?g/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	No cytotoxicity information found in the reference(s) presented	Not found	26026377##16554081	Peptides. 2015 Sep;71:296-303. ##Toxicon. 2006 May;47(6):664-675.	"VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ."	Inhibition of HIV infection by caerin 1 antimicrobial peptides.##New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry.
DRAMP01590	GLFDVIAKVASVIKKL	16	"Citropin 1.1 M14 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: E. coli (MIC=53 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.20564028]No cytotoxicity information found	Not found	20564028	Biopolymers. 2011;96(2):147-157.	"Chia CS, Gong Y, Bowie JH, Zuegg J, Cooper MA. "	"Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin."
DRAMP01591	GLFAVIKKVASVIKKL	16	"Citropin 1.1 M15 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: E. coli (MIC=53 ?M);##Gram-positive bacteria: S. aureus (MIC=3 ?M), B. subtilis (MIC=3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.20564028]No cytotoxicity information found	Not found	20564028	Biopolymers. 2011;96(2):147-157.	"Chia CS, Gong Y, Bowie JH, Zuegg J, Cooper MA. "	"Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin."
DRAMP01607	GLFDIIKKIAESF	13	"Aurein-1.2 (Frogs, amphibians, animals)"	P82387	Not found	Not found	Litoria raniformis (Southern bell frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Protein level	Alpha helix (1 helices; 10 residues)	Not found	1VM5 resolved by NMR.	Function: Probably acts by disturbing membrane functions with its amphipathic structure. Aurein 1.2 is HIV active (Wang G et al. 2010 Antimicrob. Agents Chemother. (54) 1343-1346). Aurein 1.2 is also the smallest amphibian peptide to show both antibiotic and Anti-cancer activity. The aurein antibiotics show more activity towards Gram-positive than Gram-negative pathogens. Expressed by the skin dorsal glands.	"Gram-positive bacteria: Bacillus cereus (MIC=100 ¦Ìg/ml), Leuconostoc lactis (MIC=12 ¦Ìg/ml), Listeria innocua (MIC=100 ¦Ìg/ml), Micrococcus luteus (MIC=100 ¦Ìg/ml), Staphylococcus epidermidis (MIC=50 ¦Ìg/ml), Streptococcus uberis (MIC=50 ¦Ìg/ml), Staphylococcus aureus (MIC=8 ¦Ìmol/L);##Gram-negative bacteria: Pasteurella multocida (MIC=100 ¦Ìg/ml), Escherichia coli (MIC=8 ¦Ìmol/L);##Fungi: Candida albicans (MIC=32 ¦Ìmol/L)"	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.10951191]No cytotoxicity information found##[Ref.15572363]No cytotoxicity information found	Cell membrane	10951191##15572363##15203252	Eur J Biochem. 2000 Sep;267(17):5330-5341.##J Biol Chem. 2005 Feb 18;280(7):5803-5811.##Peptides. 2004 Jun;25(6):1035-1054.	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Wang G, Li Y, Li X.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE."	"The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance."
DRAMP01618	GLFDIVKKIAGHIVSSI	17	"Aurein-3.3 (Frogs, amphibians, animals)"	P82396	Not found	Not found	Litoria raniformis (blue-thighed treefrog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Protein level	Not found	Not found	None	"Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.
Tissue specificity: Expressed by the skin dorsal glands."	"Gram-positive bacteria: Leuconostoc lactis (MIC=12 ¦Ìg/ml), Micrococcus luteus (MIC=100 ¦Ìg/ml), Staphylococcus epidermidis (MIC=50 ¦Ìg/ml), Streptococcus uberis (MIC=25 ¦Ìg/ml), Staphylococcus aureus (MIC=100 ¦Ìg/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=100 ¦Ìg/ml)"	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.10951191]No cytotoxicity information found	Cell membrane	10951191##15203252	Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054.	"Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE."	"The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance."
DRAMP01621	IIGPVLGMVGSALGGLLKKI	20	"Bombinin-H1 (Frogs, amphibians, animals)"	"P82282, P82283"	Belongs to the bombinin family	Not found	Bombina variegata (European frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antimicrobial.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation and D-amino acid."	[Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=3.8 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=2.1 ?M).	[Ref:8223491]Not determined hemolytic activity against human red blood cells.	Linear	Free	Amidation	Free	L	[Ref.8223491]No cytotoxicity information found	Not found	8223491	EMBO J. 1993 Dec;12(12):4829-4832.	"Mignogna G, Simmaco M, Kreil G, Barra D."	Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.
DRAMP03722	IFGAIWNGIKSLF	13	Cytotoxic linear peptide IsCT2	Q8MTX2	Belongs to the scorpion NDBP 5 family	Not found	Opisthacanthus madagascariensis (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: IsCT2 showed broad activity spectra against microbes (Gram positive and negative bacteria as well as fungi). Has hemolytic activity.	"[Ref.12054688] Gram-negetive bacteria: P.aeroginosa ATCC 15442 (MIC>150 ¦ÌM), P.aeroginosa ATCC 27853 (MIC=68.3 ¦ÌM), E.coli CCT 1371 (MIC=3.4 ¦ÌM), Escherichia coli ATCC 25922 (MIC=6.8 ¦ÌM), P. mirabilis (MIC>150 ¦ÌM);## Gram-positive bacteria: S.aureus ATCC 25293 (MIC=0.7 ¦ÌM), S.aureus ATCC 6538 (MIC=3.4 ¦ÌM), S.saprophyticus (MIC=0.7 ¦ÌM), B.thuringensis (MIC=17.1 ¦ÌM),  B.subtilis CCT 2471 (MIC=6.8¦ÌM).##[Ref.28657596] Gram-positive bacterium:Staphylococcus aureus (MIC=50¦Ìg/mL), B. cereus (MIC=100¦Ìg/mL);##Gram-negative bacterium: S. typhimurium (MIC=100¦Ìg/mL), Escherichia coli (MIC=50¦Ìg/mL)"	"[Ref.12054688] Showed relatively weak hemolytic activity against sheep red blood cells.##[Ref.28657596] 18% hemolysis at 10 ¦Ìg/ml, 96% hemolysis at 50 ¦Ìg/ml against human red blood cells."	Linear	Free	Amidation	Free	L	[Ref.12054688]No cytotoxicity information found##[Ref.28657596]No cytotoxicity information found	Not found	12054688##28657596	Biochem Biophys Res Commun. 2002 May 24;293(5):1514-1522.##Antibiotics (Basel). 2017 Jun 28;6(3). pii: E13.	"Dai L, Corzo G, Naoki H, Andriantsiferana M, Nakajima T.##de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM."	"Purification, structure-Function: analysis, and molecular characterization of novel linear peptides from scorpion Opisthacanthus madagascariensis.##Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides"
DRAMP01626	IIGPVLGLVGSALGGLLKKI	20	"Bombinin-H5 (Frogs, amphibians, animals)"	P82285	Belongs to the bombinin family	Not found	Bombina variegata (European frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix (1 helices; 16 residues)	Not found	"2AP7, 2AP8 resolved by NMR."	"Function: Has antimicrobial activity.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation and D-amino acid."	[Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=5.0 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.0 ?M).	[Ref:8223491]Not found	Linear	Free	Amidation	Free	Mixed (2D-aIle(alloisoleucine))	[Ref.8223491]No cytotoxicity information found	Not found	8223491##PubMed ID is not available	EMBO J. 1993 Dec;12(12):4829-4832##TO BE PUBLISHED	"Mignogna G, Simmaco M, Kreil G, Barra D.##Zangger K, Jilek A, Khatai L."	Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.##Solution structure and orientation of bombinin H2 and H4 in a membrane-mimetic environment.
DRAMP01627	YPPKPESPGEDASPEEMNKYLTALRHYINLVTRQRY	36	"Skin peptide tyrosine-tyrosine (Skin-PYY; SPYY; Frogs, amphibians, animals)"	P80952	Belongs to the NPY family	Not found	Phyllomedusa bicolor (Two-colored leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Shows a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria, yeast and fungi.
Tissue specificity: Skin.
PTM: C-terminal amidation (By similarity)."	"Gram-negative bacteria: Aeromonas caviae (MIC=40 ?g/ml), Escherichia coli (MIC=10 ?g/ml);##Gram-positive bacteria: Enterococcus faecalis (MIC=10 ?g/ml), Nocardia brasiliensis (MIC=20 ?g/ml).##Fungi: Cryptococcus neoformans (MIC=20 ?g/ml), Candida albicans (MIC=15 ?g/ml), Microsporum canis (MIC=10 ?g/ml), Tricophyton rubrum (MIC=15 ?g/ml), Arthroderma simii (MIC=10 ?g/ml), Aspergillus fumigatus (MIC=80 ?g/ml), Aspergillus niger (MIC>100 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.8601432]<20% cytotoxic against murine macrophages at the concentration up to 100¦Ìg/ml##[Ref.7937944]No cytotoxicity information found	Cell membrane	7937944##8601432	Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10295-10299.##FEBS Lett. 1996 Feb 19;380(3):237-240.	"Mor A, Chartrel N, Vaudry H, Nicolas P.##Vouldoukis I, Shai Y, Nicolas P, Mor A."	"Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.##Broad spectrum antibiotic activity of the skin-PYY."
DRAMP01628	GWMSKIASGIGTFLSGMQQ	19	"Phylloxin (Frogs, amphibians, animals)"	"P81565, Q9PT74"	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	PLX	Phyllomedusa bicolor (Two-colored leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix	Not found	None	"Function: Antimicrobial peptide against the Gram-positive bacteria and the Gram-negative-bacteria.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"Gram-negative bacteria: Acholeplasma laidlawii A-PG8 (MIC=12.5 ?M), Spiroplasma melliferum BC3 (MIC=50 ?M), Rhizobium meliloti 102F34 (MIC=12.5 ?M), Escherichia coli K12 (MIC=10 ?M);##Gram-positive bacteria: Bacillus megaterium KM (MIC=3.12 ?M), Corynebacterium glutamicum ATCC 27853 (MIC=1.56 ?M), Micrococcus luteus ATCC 27853 (MIC=3.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.10632707]No cytotoxicity information found	Not found	10632707	Eur J Biochem. 2000 Jan;267(2):370-378.	"Pierre TN, Seon AA, Amiche M, Nicolas P."	"Phylloxin, a novel peptide antibiotic of the dermaseptin family of antimicrobial/opioid peptide precursors."
DRAMP01638	GLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS	32	"Dermaseptin-L1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylomantis lemur (Lemur leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=8 ?M).##Fungi: Batrachochytrium dendrobatidis (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Free	Free	L	[Ref.17561225]Displayed cytotoxic against HepG2 cells(LC50=45¦ÌM)	Not found	17561225	Toxicon. 2007 Sep 15;50(4):498-506.	"Conlon JM, Woodhams DC, Raza H, Coquet L, Leprince J, Jouenne T, Vaudry H, Rollins-Smith LA."	Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae).
DRAMP01639	GLWSTIKNVGKEAAIAAGKAALGAL	25	"Dermaseptin-1 (DShypo01, DPh-1; Frogs, amphibians, animals)"	P84596	Not found	Not found	Phyllomedusa hypochondrialis (Orange-legged leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also has antiprotozoal activity against L. amazonensis. No hemolytic activity.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"[Ref.16963159]Gram-positive bacteria: Micrococcus luteus A270 (MIC=6 ?M), Staphylococcus aureus ATCC 6538 (MIC=6 ?M);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=6 ?M), Pseudomonas aeruginosa ATCC 14502 (MIC=6.6 ?M)."	[Ref:16844081]Non-hemolytic activity upto 53 ¦ÌM against human red blood cells;##[Ref.16963159]Non-hemolytic activity at 6 ¦ÌM against erythrocytes	Linear 	Free	Amidation	Free	L	[Ref.16844081]No cytotoxicity information found##[Ref.16963159]No cytotoxicity information found	Not found	16844081##16963159	Biochem Biophys Res Commun. 2006 Sep 1;347(3):739-746.##Peptides. 2006 Dec;27(12):3092-3099.	"Brand GD, Leite JR, de S?? Mandel SM, Mesquita DA, Silva LP, Prates MV, Barbosa EA, Vinecky F, Martins GR, Galasso JH, Kuckelhaus SA, Sampaio RN, Furtado JR Jr, Andrade AC, Bloch C Jr.##Concei?¡ì??o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC."	Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).##Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis.
DRAMP01643	GLWSTIKQKGKEAAIAAAKAAGQAALGAL	29	"Dermaseptin-5 (DShypo05, DS 01; Frogs, amphibians, animals)"	P84600	Not found	Not found	Phyllomedusa hypochondrialis (Orange-legged leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also has antiprotozoal activity against L. amazonensis. No hemolytic activity.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	[Ref.8306981]Gram-negative bacterium: Escherichia coli (MIC=6.4 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3.2 ?M).	[Ref:8306981]Non-hemolytic activity against rabbit red blood cells.	Linear	Free	Amidation	Free	L	[Ref.12379643]No cytotoxicity information found##[Ref.17442605]No cytotoxicity information found	Not found	12379643##17442605	J Biol Chem. 2002 Dec 20;277(51):49332-49340. ##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):336-343.	"Brand GD, Leite JR, Silva LP, Albuquerque S, Prates MV, Azevedo RB, Carregaro V, Silva JS, S¨¢ VC, Brand?o RA, Bloch C Jr. ##Leite JRSA, Brand GD, Silva LP, K¨¹ckelhaus SAS, Bento WRC, Ara¨²jo ALT, Martins GR, Lazzari AM, Bloch C Jr."	"Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells. ##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity. "
DRAMP01646	GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV	33	"Adenoregulin (Dermaseptin BII; Dermaseptin B2; Frogs, amphibians, animals)"	"P31107, P80283"	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	ADR	Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Fountion: Enhances binding of agonists to adenosine A1 receptors, adenosine A2a receptors, alpha-2 adrenergic receptors and 5-hydroxytryptamine 1A receptors. Enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. Affects human behavior eliciting profound malaise, followed by listlessness and then euphoria. Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Lack hemolytic activity. Probably acts by disturbing membrane functions with its amphipathic structure.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation at V33 (Amidation in vitro increases antimicrobial activity against some microorganisms such as T. album and S. cerevisia)."	"[Ref.8306981]Fungi: Microsporum canis (IP 1194) (MIC=10 ?g/ml), Tricophyton rubrum (IP 1400-82) (MIC=15 ?g/ml), Arthroderma simii (IP 1063-74) (MIC=30 ?g/ml), Aspergillus fumigatus IP (1025-70) (MIC=125 ?g/ml), Aerornonas caviae (IP 67-16 T) (MIC=60 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 ?g/ml), Candida albicans (IP 884-65) (MIC=15 ?g/ml);##Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=15 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=30 ?g/ml)."	[Ref:8306981]Lack hemolytic activity against rabbit red blood cells	Linear	Free	Free	Free	L	[Ref.8306981]No cytotoxicity information found##[Ref.1438301]No cytotoxicity information found##[Ref.7842473]No cytotoxicity information found##[Ref.8565049]No cytotoxicity information found	Not found	8306981##1438301##7842473##8565049	"Eur J Biochem 1994, 219 (1-2):145-154.##Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-10963.##Cell Mol Neurobiol. 1994 Apr;14(2):133-157.##Cell Mol Neurobiol. 1995 Aug;15(4):465-493."	"Mor, A, Nicolas, P.##Daly JW, Caceres J, Moni RW, Gusovsky F, Moos M Jr, Seamon KB, Milton K, Myers CW.##Shin Y, Moni RW, Lueders JE, Daly JW.##Moni RW, Romero FS, Daly JW."	"Isolation and structure of novel defensive peptides from frog skin.##Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor.##Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx.##The amphiphilic peptide adenoregulin enhances agonist binding to A1-adenosine receptors and [35S]GTP gamma S to brain membranes."
DRAMP01648	GLVTSLIKGAGKLLGGLFGSVTGGQS	26	"Dermaseptin-like PBN2 (DRP-PBN2; Plasticin-B1a; Frogs, amphibians, animals)"	Q800R4	Not found	Not found	Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Possesses a potent antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and fungi. Probably acts by disturbing membrane functions with its amphipathic structure."	"Gram-negative bacteria: Escherichia coli B (MIC=1.5 ?M), Salmonella typhimurium (MIC=3.1 ?M), Salmonella enteritidis (MIC=1.5 ?M), Enterobacter cloacae (MIC=12.5 ?M), Klebsiella pneumoniae (MIC=0.8 ?M);##Gram-positive bacteria: Aerococcus viridans (MIC=3.1 ?M), Bacillus megaterium (MIC=0.8 ?M), Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus haemolyticus (MIC=0.8 ?M).##Fungi: Saccaromyces cerevisiae (MIC=3.1 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.12709067]No cytotoxicity information found##[Ref.15222751]No cytotoxicity information found	Not found	12709067##15222751	Eur J Biochem. 2003 May;270(9):2068-2081.##Biochemistry. 2004 Jul 6;43(26):8391-8409.	"Vanhoye D, Bruston F, Nicolas P, Amiche M.##Vanhoye D, Bruston F, El Amri S, Ladram A, Amiche M, Nicolas P."	"Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Membrane association, electrostatic sequestration, and cytotoxicity of Gly-Leu-rich peptide orthologs with differing functions."
DRAMP01649	AMWKDVLKKIGTVALHAGKAALGAVADTISQ	31	"Dermaseptin-BI (Dermaseptin B1; Frogs, amphibians, animals)"	P80282	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	Not found	Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation (Potential)."	"Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=15 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=30 ?g/ml).##Fungi: Tricophyton rubrum (IP 1400-82) (MIC=15 ?g/ml), Microsporum canis (IP 1194) (MIC=10?g/ml), Arthroderma simii (IP 1063-74) (MIC=30 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neofonnans (IP 962-67) (MIC=15 ?g/ml), Aspergillus fumigatus (IP 1025-70)(MIC=125 ?g/ml), Aerornonas caviae (IP 67-16 T) (MIC=60 ?g/ml), Candida albicans (IP 884-65) (MIC=15 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.8306981]No cytotoxicity information found##[Ref.8074751]No cytotoxicity information found	Not found	8306981##8074751	Eur J Biochem. 1994 Jan 15;219(1-2):145-154.##J Biol Chem. 1994 Jul 8;269(27):17847-17852.	"Mor A, Nicolas P.##Amiche M, Ducancel F, Mor A, Boulain JC, Menez A, Nicolas P."	"Isolation and structure of novel defensive peptides from frog skin.##Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins."
DRAMP01650	ALWKNMLKGIGKLAGQAALGAVKTLVGAE	29	"Dermaseptin-B3 (Dermaseptin BIII; Frogs, amphibians, animals)"	P81485	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	Not found	Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.
Tissue specificity: Expressed by the skin glands."	"Gram-negative bacteria: Pseudomonas aeruginosa CIP A22 (MIC=2.3 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=5 ?M), Escherichia coli ATCC 25922 (MIC=2.6 ?M), E. coli 54127 (MIC=2.3 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25293 (MIC=1.3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.9614066]No cytotoxicity information found	Not found	9614066	J Biol Chem. 1998 Jun 12;273(24):14690-14697.	"Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A."	"Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics."
DRAMP01651	ALWKDILKNVGKAAGKAVLNTVTDMVNQ	28	"Dermaseptin-B4 (Dermaseptin BIV; Frogs, amphibians, animals)"	P81486	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	Not found	Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix	Not found	None	"Function: Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"Gram-positive bacteria: Staphylococcus aureus ATCC 25293 (MIC=1.3 ?M), S. aureus ATCC 25923 (MIC=3.0 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa CIP A22 (MIC=4.6 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=11.6 ?M), Escherichia coli ATCC 25922 (MIC=5.0 ?M), E. coli 54127 (MIC=2.3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.9614066]No cytotoxicity information found	Not found	9614066	J Biol Chem. 1998 Jun 12;273(24):14690-14697.	"Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A."	"Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics."
DRAMP01668	ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ	34	"Dermaseptin-1 (DS I; Dermaseptin-S1, DS1; Frogs, amphibians, animals)"	"P24302, P80277"	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	Not found	Phyllomedusa sauvagei (Sauvage's leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal"	Protein level	Alpha helix (CD)	Not found	None	"Function: Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. This peptide could also inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606).
Tissue specificity: Expressed by the skin glands."	"Fungi: Microsporum canis (IP 1194) (MIC=50 ?g/ml), Tricophyton rubrum (IP 1400-82) (MIC=100 ?g/ml), Arthroderma simii (IP 1063-74) (MIC=100 ?g/ml), Aspergillus fumigatus (IP 1025-70) (MIC=100 ?g/ml), Aerornonas caviae IP (67-16) T (MIC=50 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 ?g/ml), Candida albicans (IP 884-65) (MIC=60 ?g/ml); ##Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=5 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=200 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	Free	L	[Ref.1909573]No cytotoxicity information found##[Ref.8306981]No cytotoxicity information found	Cell membrane	1909573##8306981	Biochemistry. 1991 Sep 10;30(36):8824-8830.##Eur J Biochem. 1994 Jan 15;219(1-2):145-154. 	"Mor A, Nguyen VH, Delfour A, Migliore-Samour D, Nicolas P.##Mor A, Nicolas P."	"Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin.##Isolation and structure of novel defensive peptides from frog skin."
DRAMP01702	GLWSTIKNVGKEAAIAAGKAVLGSL	25	"Dermaseptin-H5 (Dermaseptin-like peptide 5, DMS5; Frogs, amphibians, animals)"	Q1EJP4	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	Not found	Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	MOA: Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).	"Gram-negative bacterium: Escherichia coliEscherichia coli ATCC 11775 (MIC=0.5 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (MIC=0.5 ?M), Micrococcus luteus ATCC 49732 (MIC=2.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	Free	L	[Ref.17553595]No cytotoxicity information found	Not found	17553595	Peptides. 2007 Jul;28(7):1331-1343.	"Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S."	A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.
DRAMP01731	FLPIAGKLLSGLSGLL	16	"Temporin-ALd (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Temporin-ALd exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1.25 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=15 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)."	[Ref:19843479]12% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells	Linear	Free	Amidation	Free	L	[Ref.19843479]No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis."
DRAMP01732	FFPIVGKLLFGLSGLL	16	"Temporin-ALe (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Temporin-ALe exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=5 ?g/mL), Bacillus cereus (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1.25 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=15 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)."	[Ref:19843479]10% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells	Linear	Free	Amidation	Free	L	[Ref.19843479]No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis."
DRAMP01733	FFPIVGKLLSGLSGLL	16	"Temporin-ALf (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Temporin-ALf exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=5 ?g/mL), Bacillus cereus (MIC=30 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=2.5 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=30 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)."	[Ref:19843479]7% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells.	Linear	Free	Amidation	Free	L	[Ref.19843479]No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis."
DRAMP01734	FFPIVGKLLFGLFGLL	16	"Temporin-ALg (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Temporin-ALg exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=30 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?g/mL), Bacillus dysenteriae (MIC=10 ?g/mL), Acinetobacter calcoaceticus (MIC=30 ?g/mL), Psecdomonas aeruginosa (MIC=7.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)."	[Ref:19843479]16% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells.	Linear	Free	Amidation	Free	L	[Ref.19843479]No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis."
DRAMP01735	FLPIVGKLLSGLSGLS	16	"Temporin-ALh (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Temporin-ALh exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=7.5 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?g/mL), Bacillus dysenteriae (MIC=20 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=2.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)."	[Ref:19843479]13% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells.	Linear	Free	Amidation	Free	L	[Ref.19843479]No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis."
DRAMP01736	FFPIVGKLLSGLL	13	"Temporin-ALi (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Temporin-ALi exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=7.5 ?g/mL), Bacillus pumilus (MIC=7.5 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=7.5 ?g/mL), Bacillus dysenteriae (MIC=20 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=5 ?g/mL)."	[Ref:19843479]21% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells	Linear	Free	Amidation	Free	L	[Ref.19843479]No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis."
DRAMP01737	FFPIVGKLLFGLL	13	"Temporin-ALj (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Temporin-ALg exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=7.5 ?g/mL), Bacillus pumilus (MIC=15 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=15 ?g/mL), Bacillus dysenteriae (MIC=30 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=7.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=5 ?g/mL)."	[Ref:19843479]19% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells.	Linear	Free	Amidation	Free	L	[Ref.19843479]No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis."
DRAMP01738	FFPIVGKLLS	10	"Temporin-ALk (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops loloensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Temporin-ALk exhibits hemolytic activity against rabbit red blood cells.	"[Ref.19843479]Gram-positive bacterium: Staphylococcus aureus ATCC2592 (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 ?g/mL), Bacillus dysenteriae (MIC=60 ?g/mL), Acinetobacter calcoaceticus (MIC=75 ?g/mL), Psecdomonas aeruginosa (MIC=25 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=15 ?g/mL)."	[Ref:19843479]25% hemolytic activity at 100 ¦Ìg/mL against rabbit red blood cells.	Linear	Free	Amidation	Free	L	[Ref.19843479]No cytotoxicity information found	Not found	19843479	Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.	"Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R."	"Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis."
DRAMP01753	FVDLKKIANIINSIFGK	17	"Temporin-1CEa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana chensinensis (Chinese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Alpha helix 	Not found	None	Function: Temporin-1CEa exhibits the greatest ability to inhibit the growth of MCF-7 cells. Also temporin-1CEa shows hemolytic effect to human erythrocytes and has no significant cytotoxicity to normal HUVSMCs at concentrations showed potent antitumor activity. 	"[Ref.21871946]Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 ?M), Bacillus cereus (MIC=14.4 ?M), Streptococcus lactis (MIC=14.4 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M)."	[Ref:21871946]LD50=99.08 ¦ÌM against human erythrocytes	Linear	Free	Amidation	Free	L	[Ref.19341344]No cytotoxicity information found##[Ref.21871946]No determined cytotoxic against SMCs at the concentration between 20-60 ¦ÌM.	Not found	21871946##19341344	Biochimie. 2012 Feb;94(2):434-441.##Zoolog Sci. 2009 Mar;26(3):220-226.	"Wang C, Li HB, Li S, Tian LL, Shang DJ.##Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y."	"Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis).##Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis."
DRAMP01754	ILPILSLIGGLLGK	14	"Temporin-1CEb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana chensinensis (Chinese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus (MIC=41 ?M), Bacillus cereus (MIC=41 ?M), Streptococcus lactis (MIC=41 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.19341344]No cytotoxicity information found	Not found	19341344	Zoolog Sci. 2009 Mar;26(3):220-226.	"Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y."	"Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis."
DRAMP01755	FLGALAKIISGIF	13	"Temporin-1TSa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana tsushimensis (Tsushima brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.16413829]No cytotoxicity information found	Not found	16413829	Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. 	"Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S."	Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis.
DRAMP01764	FLPILGKLLSGIL	13	"Temporin-1TGa (Frogs, amphibians, animals)"	Q2PGA8	Belongs to the frog skin active peptide family (Brevinin subfamily)	tmpTGa	Rana tagoi (Tago frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M).##Yeast: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.12804591]No cytotoxicity information found##[Ref.16675060]No cytotoxicity information found	Not found	12804591##16675060	Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.##Peptides. 2006 Sep;27(9):2124-2128.	"Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, P??l T.##Iwamuro S, Nakamura M, Ohnuma A, Conlon JM."	"A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties.##Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi."
DRAMP01765	AVDLAKIANKVLSSLF	16	"Temporin-1TGb (Frogs, amphibians, animals)"	Q2PGA7	Belongs to the frog skin active peptide family (Brevinin subfamily)	tmpTGb	Rana tagoi (Tago frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC>150 ?M);##Gram-negative bacterium: Escherichia coli (MIC=37.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.16675060]No cytotoxicity information found	Not found	16675060	Peptides. 2006 Sep;27(9):2124-2128.	"Iwamuro S, Nakamura M, Ohnuma A, Conlon JM."	Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi.
DRAMP01766	FLPVILPVIGKLLSGIL	17	"Temporin-1TGc (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana tagoi (Tago's brown frog); also Rana sakuraii	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC=37.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC>150 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.16675060]No cytotoxicity information found	Not found	16675060	Peptides. 2006 Sep;27(9):2124-2128.	"Iwamuro S, Nakamura M, Ohnuma A, Conlon JM."	Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi.
DRAMP01771	FLPLLASLFSRLL	13	"Temporin-1Oa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana ornativentris (Japanese mountain brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=70 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	Free	L	[Ref.17147973]No cytotoxicity information found	Not found	17147973	Peptides. 2007 Mar;28(3):524-532.	"Ohnuma A, Conlon JM, Yamaguchi K, Kawasaki H, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S."	Antimicrobial peptides from the skin of the Japanese mountain brown frog Rana ornativentris: evidence for polymorphism among preprotemporin mRNAs.
DRAMP01775	FLSGIVGMLGKLFGK	15	"Temporin-1Sa (Frogs, amphibians, animals)"	B3KYH4	Belongs to the frog skin active peptide family (Brevinin subfamily)	preproTemp-1Sa	Pelophylax saharicus (Sahara frog) (Rana saharica)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Activity against Gram-positive and Gram-negative bacteria, and has hemolytic activity against human erythrocytes."	"[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3 ?M), Enterococcus faecalis ATCC 29212 (MIC=10 ?M), Bacillus megaterium (MIC=2 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10 ?M), Escherichia coli ATCC 35218 (MIC=10 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=31 ?M);##Fungi: Candida albicans ATCC 90028 (MIC=16 ?M), Candida parapsilosis ATCC 22019 (MIC=31 ?M), Saccharomyces cerevisiae (MIC=8 ?M)."	[Ref:18584916]LC50=25 ¦ÌM against human erythrocytes	Linear	Free	Amidation	Free	L	[Ref.18584916]No cytotoxicity information found	Not found	18584916	Peptides. 2008 Sep;29(9):1526-1523.	"Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A"	"Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica."
DRAMP01776	FLPIVTNLLSGLLGK	15	"Temporin-1Sb (Temporin-SHb; Frogs, amphibians, animals)"	B3KYH5	Belongs to the frog skin active peptide family (Brevinin subfamily)	preproTemp-1Sb	Pelophylax saharicus (Sahara frog) (Rana saharica)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Activity against Gram-positive and Gram-negative bacteria, and has strong hemolytic activity against human erythrocytes."	"[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=58 ?M), Enterococcus faecalis ATCC 29212 (MIC>116 ?M), Bacillus megaterium (MIC=46 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=231 ?M), Escherichia coli ATCC 35218 (MIC>116 ?M);##Fungi: Aspergillus flavus (MIC=58 ?M)."	[Ref:18584916]LC50>116 ¦ÌM against human erythrocytes	Linear	Free	Amidation	Free	L	[Ref.18584916]No cytotoxicity information found	Not found	18584916	Peptides. 2008 Sep;29(9):1526-1523.	"Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A"	"Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica."
DRAMP01777	FLSHIAGFLSNLFGK	15	"Temporin-1Sc (Temporin-SHc; Frogs, amphibians, animals)"	B3KYH6	Belongs to the frog skin active peptide family (Brevinin subfamily)	preproTemp-1Sc	Pelophylax saharicus (Sahara frog) (Rana saharica)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Alpha helix	Not found	None	"Function: Activity against a range of Gram-positive and Gram-negative bacteria, and has hemolytic activity against human erythrocytes."	"[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC>80 ?g/ml), Bacillus megaterium (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=161 ?g/ml), Escherichia coli ATCC 35218 (MIC>80 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>161 ?g/ml);##Fungi: Aspergillus flavus (MIC=10 ?g/ml), Candida albicans ATCC 90028 (MIC=20 ?g/ml), Candida parapsilosis ATCC 22019 (MIC=20 ?g/ml), Saccharomyces cerevisiae (MIC=10 ?g/ml)."	[Ref:18584916]LC50>80 ¦ÌM against human erythrocytes	Linear	Free	Amidation	Free	L	[Ref.18584916]No cytotoxicity information found	Not found	18584916	Peptides. 2008 Sep;29(9):1526-1523.	"Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A"	"Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica."
DRAMP01779	FFFLSRIFGK	10	"Temporin-SHf (Frogs, amphibians, animals)"	D4YWD1	Belongs to the frog skin active peptide family (Brevinin subfamily)	preproTemp-SHf	Pelophylax saharicus (Sahara frog) (Rana saharica)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25-200 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.20308076]No cytotoxicity information found	Not found	20308076	J Biol Chem. 2010 May 28;285(22):16880-16892.	"Abbassi F, Lequin O, Piesse C, Goasdoue N, Foulon T, Nicolas P, Ladram A."	"Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide."
DRAMP01780	FLSGIVGMLGKLF	13	"Temporin-SHa (Temporin-1Sa; Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Pelophylax saharica (North Africa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Bacillus megaterium (MIC=2 ?M);##Gram-negative bacterium: Escherichia coli (MIC=10 ?M).##Yeast: Candida albicans (MIC=16 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.31614561]Display cytotoxic against human gastric cells(N87 cell:IC50=1558 ¡À 324¦ÌM)	Not found	31614561	Biomolecules. 2019 Oct 11;9(10):598.	"Olleik H, Baydoun E, Perrier J, Hijazi A, Raymond J, Manzoni M, Dupuis L, Pauleau G, Goudard Y, Vill¨¦on B, Goin G, Sockeel P, Choudhary MI, Pasquale ED, Nadeem-Ul-Haque M, Ali H, Khan AI, Shaheen F, Maresca M. "	Temporin-SHa and Its Analogs as Potential Candidates for the Treatment of Helicobacter pylori. 
DRAMP01784	SLSRFLSFLKIVYPPAF	17	"Temporin-LTc (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Hylarana latouchii (broad-folded frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Not found	Not found	Not found	None	Comment: A mutant of the peptide is also HIV inhibitory (Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346).	"Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?g/ml), Bacillus subtilis (MIC=50 ?g/ml);##Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.19022312]No cytotoxicity information found	Not found	19022312	Peptides. 2009 Feb;30(2):273-282.	"Wang H, Lu Y, Zhang X, Hu Y, Yu H, Liu J, Sun J."	"The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae)."
DRAMP01785	IPPFIKKVLTTVF	13	"Temporin-CPa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates capito (New World frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: For this series of peptides, there were not enough material for antimicrobial assays. It displayed hemolytic activity (human red blood cells) at LC50=220 uM. "	[Ref.19635516]Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=50 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=25 ?M).	[Ref:19635516]LC50=220 ¦ÌM against human erythrocytes	Linear	Free	Amidation	Free	L	[Ref.19635516]No cytotoxicity information found	Not found	19635516	Peptides. 2009 Oct;30(10):1775-1781.	"Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD."	Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae).
DRAMP01787	AILTTLANWARKFL	14	"Temporin-HN1 (Frogs, amphibians, animals)"	E7EKD0	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hainanensis (Hainan odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has hemolytic activity against washed human erythrocytes (IC50=75 ?M).	"[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=37.5 ?M), Staphylococcus carnosus KHS (MIC=37.5 ?M), Bacillus licheniformis X39 (MIC=19 ?M), Rhodococcus rhodochrous X15 (MIC=4.8 ?M);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=75 ?M);##Fungi: Slime mould 090223 (MIC=19 ?M), Candida albicans ATCC2002 (MIC=75 ?M)."	[Ref:22450466]IC50=75 ?M against washed human erythrocytes	Linear	Free	Amidation	Free	L	[Ref.22450466]No cytotoxicity information found	Not found	22450466	Peptides. 2012 Jun;35(2):285-290. 	"Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J."	"Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis."
DRAMP01788	NILNTIINLAKKIL	14	"Temporin-HN2 (Frogs, amphibians, animals)"	E7EKD4	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hainanensis (Hainan odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=4.8 ?M), Staphylococcus carnosus KHS (MIC=19 ?M), Bacillus licheniformis X39 (MIC=19 ?M),Rhodococcus rhodochrous X15 (MIC=2.4 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=37.5 ?M).##Fungi: Slime mould 090223 (MIC=9.5 ?M) and Candida albicans ATCC2002 (MIC=9.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.22450466]No cytotoxicity information found	Not found	22450466	Peptides. 2012 Jun;35(2):285-290. 	"Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J."	"Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis."
DRAMP01789	FLSSIGKILGNLL	13	"Temporin-1Va (Temporin 1Va; Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana virgatipes (Ranidae) (Aquarana)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: It also has weak hemolytic activty.	"[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=10 ?M), S. aureus (MRSA) T7/20 (MIC=20 ?M), S. epidermidis RP62A (MIC=20 ?M), Enterococcus faecalis ATCC 29212 (MIC=40 ?M), Streptococcus group B HNTCC 80130 (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=40 ?M), Klebsiella pneumoniae KK3 9904 (MIC=80 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=160 ?M), Enterobacter cloacae HNTCC 53001 (MIC=40 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=160 ?M)."	[Ref:15996769]LD50=120 ¦ÌM against washed human erythrocytes	Linear	Free	Amidation	Free	L	[Ref.15996769]No cytotoxicity information found	Not found	15996769	Regul Pept. 2005 Nov;131(1-3):38-45.	"Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR."	"Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). "
DRAMP01791	FLPLVTMLLGKLF	13	"Temporin-1Vc (Temporin 1Vc; Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana virgatipes (Ranidae) (Aquarana)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: It also has weak hemolytic activty.	"[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=5 ?M), S. aureus (MRSA) T7/20 (MIC=10 ?M), S. epidermidis RP62A (MIC=10 ?M), Enterococcus faecalis ATCC 29212 (MIC=40 ?M), Streptococcus group B HNTCC 80130 (MIC=40 ?M);##Gram-negative bacteria: Klebsiella pneumoniae KK3 9904 (MIC=80 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=160 ?M), Enterobacter cloacae HNTCC 53001 (MIC=40 ?M)."	[Ref:15996769]LD50=30 ¦ÌM against washed human erythrocytes	Linear	Free	Amidation	Free	L	[Ref.15996769]No cytotoxicity information found	Not found	15996769	Regul Pept. 2005 Nov;131(1-3):38-45.	"Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR."	"Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). "
DRAMP01807	FLPLVLGALSGILPKIL	17	"Temporin-RN1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana nigrovittata	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC=4.69 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa PAO1 (MIC=4.7 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.19778602]No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71. 	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP01808	FFPLLFGALSSHLPKLF	17	"Temporin-RN3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana nigrovittata	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC=3.75 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa PAO1 (MIC=3.75 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.19778602]No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71. 	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP01811	FLKPLFNAALKLLP	14	"Temporin-Ra (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana ridibunda (marsh frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"At 60 ug/ml, the peptide showed about 1.3% hemolysis."	"Gram-negative bacteria: Escherichia coli (MIC=24.2 ?g/ml), Klebsiella pneumoniae PTCC 1388 (MIC=31.2 ?g/ml);##Gram-positive bacteria: Streptococcus dysgalactiae PTCC 1074 (MIC=33.2 ?g/ml), Streptococcus agalactiae PTCC 1365 (MIC=24.7 ?g/ml) and Staphylococcus aureus PTCC 1431 (MIC=35.2 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.21956830]No cytotoxicity information found	Not found	21956830	J Pept Sci. 2012 Jan;18(1):10-16.	"Asoodeh A, Zardini HZ, Chamani J."	"Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda)."
DRAMP01812	FLPVLAGVLSRA	12	"Temporin-Rb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana ridibunda (marsh frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"At 60 ug/ml, the peptide showed about 1.1% hemolysis. "	"Gram-positive bacteria: Streptococcus dysgalactiae PTCC 1074 (MIC=21.8 ?g/ml), Streptococcus agalactiae PTCC 1365 (MIC=30.5 ?g/ml), Staphylococcus aureus PTCC 1431 (MIC=42.1 ?g/ml), Staphylococcus typhimurium (MIC=31.8 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=34.5 ?g/ml), Klebsiella pneumoniae PTCC 1388 (MIC=35.1 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.21956830]No cytotoxicity information found	Not found	21956830	J Pept Sci. 2012 Jan;18(1):10-16.	"Asoodeh A, Zardini HZ, Chamani J."	"Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda)."
DRAMP01816	FLPIIGKLLSGLL	13	"Temporin-1CSb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana cascadae (Cascades frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=128 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.17451843]No cytotoxicity information found	Not found	17451843	Peptides 2007; 28: 1268-1274.	"Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C."	Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.
DRAMP01817	FLPLVTGLLSGLL	13	"Temporin-1CSc (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana cascadae (Cascades frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC>128 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=64 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.17451843]No cytotoxicity information found	Not found	17451843	Peptides 2007; 28: 1268-1274.	"Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C."	Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.
DRAMP01818	NFLGTLVNLAKKIL	14	"Temporin-1CSd (Temporin-1DRb; Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana cascadae (Cascades frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=64 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=16 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	Free	L	[Ref.17451843]No cytotoxicity information found	Not found	17451843	Peptides 2007; 28: 1268-1274.	"Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C."	Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.
DRAMP03510	KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK	37	Cecropin A	P01507	cecropin	Not found	Hyalophora cecropia	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha-helix 	Not found	1D9J	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.	"[Ref.7140755] Gram-negative bacterium: Escherichia coli D21 (LC=0.19 ?M), Escherichia coli D31 (LC=0.21 ?M), Serratia marcescens Db11 (LC=4.2 ?M), Serratia marcescens Db1108 (LC=2.5 ?M), Serratia marcescens Db1121 (LC=4.4 ?M), Serratia marcescens Strain 122 (LC=3.2 ?M), Pseudomonas aeruginosa OT97 (LC=4.8 ?M), Xenorhabdus nematophilus Xn21 (LC=1.4 ?M).##[Ref.29925795]Gram-negative bacterium:Escherichia coli CVCC 245 (MIC=4.2 ¡À 0.35¦Ìg/mL);##Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC=198 ¡À 10.1¦Ìg/mL),L. mono. CVCC 1599 (MIC=64.5 ¡À 3.20¦Ìg/mL)"	[Ref.29925795] 50% hemolysis at 169 ¡À 8.20 ¦Ìg/ml  against sheep red blood cells.	Linear	Free	Amidation	Free	L	[Ref.29925795]No cytotoxicity information found##[Ref.7140755]No cytotoxicity information found	Not found	7140755##29925795	Eur J Biochem. 1982 Sep;127(1):207-217.##Molecules. 2018 Jun 20;23(6):1491.	"Hultmark D, Engstr?m A, Bennich H, Kapur R, Boman HG.##Wei X, Wu R, Zhang L, Ahmad B, Si D, Zhang R."	"Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae.##Expression, Purification, and Characterization of a Novel Hybrid Peptide with Potent Antibacterial Activity"
DRAMP01391	GCSRWIIGIHGQICRD	16	"Odorranain-U1 (OdU1; Frogs, amphibians, animals)"	A6MBS4	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Odorranain-U1 adopts 60.2% 	None	Function: Odorranain-U1 exhibites moderate antimicrobial activities against all of the tested microbes.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC>100 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=75.00 ¦Ìg/ml), Bacillus subtilis (MIC=9.37 ¦Ìg/ml).##Yeast: Candida albicans (MIC=9.37 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01832	FLPGLLAGLL	10	"Temporin-Eca (Frogs, amphibians, animals)"	C0HJB9	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Euphlyctis cyanophlyctis (Skittering frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml, respectively.
Tissue specificity: Expressed by the skin glands."	"[Swiss_Prot Entry C0HJB9]Gram-negative bacteria: Escherichia coli HP101BA (MIC=12.3 ?M), Klebsiella pneumoniae PTCC1388 (MIC=9.8 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=8.3 ?M), Staphylococcus aureus PTCC1431 (MIC=10.6 ?M)."	[Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Int. J. Pept. Res. Ther. 2012;18:107-115.	"Asoodeh A, Ghorani-Azam A, Chamani JK."	Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis.
DRAMP01833	RAGLKFPVGRVHRLLR	16	"Buforin-EC (Frogs, amphibians, animals)"	C0HJB7	Belongs to the histone H2A family	Not found	Euphlyctis cyanophlyctis (Skittering frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml, respectively.
Tissue specificity: Expressed by the skin glands."	"[Swiss_Prot Entry C0HJB7]Gram-negative bacteria: Escherichia coli HP101BA (MIC=9.6 ?M), Klebsiella pneumoniae PTCC1388 (MIC=10.6 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=6.0 ?M), Staphylococcus aureus PTCC1431 (MIC=8.1 ?M)."	[Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Int. J. Pept. Res. Ther. 2012;18:107-115.	"Asoodeh A, Ghorani-Azam A, Chamani JK."	Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis.
DRAMP01834	FLNALKNFAKTAGKRLKSLLN	21	"Cyanophlyctin (Frogs, amphibians, animals)"	C0HJB8	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Euphlyctis cyanophlyctis (Skittering frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml.
Tissue specificity: Expressed by the skin glands."	"[Swiss_Prot Entry C0HJB8]Gram-negative bacteria: Escherichia coli HP101BA (MIC=6.4 ?M), Klebsiella pneumoniae PTCC1388 (MIC=7.3 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=4.7 ?M), Staphylococcus aureus PTCC1431 (MIC=5.3 ?M)."	[Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Int. J. Pept. Res. Ther. 2012;18:107-115.	"oodeh A, Ghorani-Azam A, Chamani JK."	Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis.
DRAMP01840	GFRDVLKGAAKAFVKTVAGHIAN	23	"Ascaphin-1 (Frogs, amphibians, animals)"	P0CJ25	Belongs to the ascaphin family	Not found	Ascaphus truei (Coastal tailed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: Asparagine amide at position 23.	[Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M).	[Ref.15207717]HC50>200 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15207717	Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.	"Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF."	"The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei."
DRAMP01842	GFRDVLKGAAKAFVKTVAGHIANI	24	"Ascaphin-3 (Frogs, amphibians, animals)"	P0CJ27	Belongs to the ascaphin family	Not found	Ascaphus truei (Coastal tailed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands.	[Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M).	[Ref.15207717]HC50>200 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15207717	Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.	"Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF."	"The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei."
DRAMP01844	GIKDWIKGAAKKLIKTVASNIANQ	24	"Ascaphin-5 (Frogs, amphibians, animals)"	P0CJ29	Belongs to the ascaphin family	Not found	Ascaphus truei (Coastal tailed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands.	"[Ref.15207717]Gram-negative bacteria: Escherichia coli (MIC=6 ?M), Pseudomonas aeruginosa (MIC=13 ?M), Enterobacter cloacae (MIC=6 ?M), Klebsiella pneumoniae (MIC=13 ?M), Proteus mirabilis (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?M), Staphylococcus epidermidis (MIC=13 ?M), Enterococcus faecalis (MIC>100 ?M), Streptococcus Group B (MIC=6 ?M);##Yeast: Candida albicans (MIC=100 ?M)."	[Ref.15207717]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15207717	Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.	"Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF."	"The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei."
DRAMP01846	GFKDWIKGAAKKLIKTVASSIANQ	24	"Ascaphin-7 (Frogs, amphibians, animals)"	P0CJ31	Belongs to the ascaphin family	Not found	Ascaphus truei (Coastal tailed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands.	[Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M).	[Ref.15207717]HC50>200 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15207717	Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.	"Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF."	"The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei."
DRAMP01847	GFKDLLKGAAKALVKTVLF	19	"Ascaphin-8 (Frogs, amphibians, animals)"	P0CJ32	Belongs to the ascaphin family	Not found	Ascaphus truei (Coastal tailed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide that shows similar potency against Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: Phenylalanine amide at position 19.	[Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).	[Ref.15207717]HC50=50 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15207717	Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.	"Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF."	"The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei."
DRAMP01849	DSMGAVKLAKLLIDKMKCEVTKAC	24	"Jindongenin-1a (JD1a; Frogs, amphibians, animals)"	G3ETQ2	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops jingdongensis (Chinese torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Also displays antifungal activity against C. albicans ATCC 2002. Has hemolytic activity, low cytotoxicity and low antioxidant activity."	"[Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=17 ?M), Enterococcus faecalis ATCC29212 (MIC=60 ?M), Staphylococcus aureus (IS 10#)(MIC=40 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=10 ?M), Enterobacter cloacae ATCC13047 (MIC=40 ?M), Klebsiella pneumoniae ATCC700603 (MIC=15 ?M), Bacillus pyocyaneus CMCCB1010 (MIC=17 ?M), Pseudomonas aeruginosa ATCC27853 (MIC=23 ?M), Bacillus dysenteriae (MIC=40 ?M);##Yeast: Candida albicans ATCC2002 (MIC=60 ?M)."	[Ref.21816202] IC50=150 ¦ÌM against washed human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	[Ref.21816202] Cytotoxicity: the K562 (IC50=46¦ÌM)and HT29 mammalian cell lines(IC50=40¦ÌM).	Not found	21816202	Biochimie. 2012 Feb;94(2):328-334.	"Chen Z, Yang X, Liu Z, Zeng L, Lee W, Zhang Y."	"Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis."
DRAMP01869	FFPIIAGMAAKLIPSLFCKITKKC	24	"Brevinin-1SPa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana septentrionalis (mink frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes.	[Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M);##Yeast: Candida albicans (MIC=7 ?M).	[Ref.15556063]HC50=7 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15556063	Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.	"Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).
DRAMP01870	FLPIIAGMAAKVICAITKKC	20	"Brevinin-1SPb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana septentrionalis (mink frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes (HC50=6 ?M).	[Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=13 ?M);##Yeast: Candida albicans (MIC=25 ?M).	[Ref.15556063]HC50=25 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15556063	Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.	"Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).
DRAMP01872	FFPIIAGMAAKVICAITKKC	20	"Brevinin-1SPd (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana septentrionalis (mink frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes.	[Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 ?M);##Yeast: Candida albicans (MIC=8 ?M).	[Ref.15556063]HC50=8 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15556063	Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.	"Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).
DRAMP01873	GIWDTIKSMGKVFAGKILQNL	21	"Brevinin-2-related peptide (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana septentrionalis (mink frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes.
Sequence similarity: This peptide shows limited structural similarity with the N-terminal region of brevinin-2 peptides previously isolated from R. temporaria skin but lacks the C-terminal cyclic heptapeptide domain associated with this family.
PTM: C-terminal amidation."	[Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M);##Yeast: Candida albicans (MIC=70 ?M).	[Ref.15556063]HC50=70 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15556063	Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.	"Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).
DRAMP04213	KKLFKKILKYL	11	BP100	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	The peptide adopted with positively charged residues on one face and the hydrophobic residues on the opposite face of the helix	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria.  Has hemolytic activity.	[Ref.29750913] Gram-negative bacteria:Escherichia coli(ATCC 25922)(MIC=2 ¦ÌM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=2¦ÌM);Bacillus subtilis(PY79)(MIC=2¦ÌM)	[Ref.29750913] 10% hemolysis at 64¦ÌM against human red blood cell	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29750913	Biochim Biophys Acta. 2018 Aug;1860(8):1502-1516. 	"Carretero GPB, Saraiva GKV, Cauz ACG, Rodrigues MA, Kiyota S, Riske KA, Dos Santos AA, Pinatto-Botelho MF, Bemquerer MP, Gueiros-Filho FJ, Chaimovich H, Schreier S, Cuccovia IM."	"Synthesis, biophysical and functional studies of two BP100 analogues modified by a hydrophobic chain and a cyclic peptide."
DRAMP03571	LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	37	LL-37	"P49913,Q71SN9"	Belongs to the cathelicidin family	CAMP	Human lysosomes of polymorphonuclear leukocytes	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Protein level	Alpha helix	The peptide adopted 1 helices and 30 residues and a curved amphipathic helix-bend-helix motif spanning residues 2-31 followed by a disordered C-terminal tail. The helical bend is located between residues Gly-14 and Glu-16.	2K6O resolved by NMR	Function:Antibacterial activity against the Gram-positive and Gram-negative bacteria. Has hemolytic activity.	[Ref.29859288] Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=25?¡À?0 ¦Ìg/ml);ESBL-producing Escherichia coli(MIC=33.3?¡À?14.4¦Ìg/ml);NDM-1 producing Acinetobacter baumannii(MIC=20.8?¡À?7.2 ¦Ìg/ml);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=133.3?¡À?57.7¦Ìg/ml);##Fungi:Candida albicans (ATCC 90028)(MIC>400¦Ìg/ml)	[Ref.29859288] 2.9?¡À?0.7% Hemolysis  at 500¦Ìg/ml against human red blood cell	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29859288	Gene. 2018 May 30. pii: S0378-1119(18)30617-6.	"Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S."	Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro.
DRAMP01748	FFPIVGKRLYGLL	13	"Temporin-AJ8 (Frogs, amphibians, animals)"	K7Z903 	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops jingdongensis (torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Shows antimicrobial abilities against microorganisms including Gram-negative and Gram-positive bacteria, and fungi. Has hemolytic activity."	"[Ref.22828809] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=70 ¦Ìg/ml), B. dysenteriae(MIC=18.75 ¦Ìg/ml) ;## Gram-positive bacteria: Staphylococcus aureus ATCC 2592(MIC=4.7 ¦Ìg/ml), Bacillus subtilis ATCC 6633(MIC=9.38 ¦Ìg/ml);## Yeast: Candida albicans ATCC 2002(MIC=37.5 ¦Ìg/ml)."	"[Ref.22828809] 1.79% hemolysis at 25¦Ìg/ml, 5.22% hemolysis at 50¦Ìg/ml, 7.92% hemolysis at 100¦Ìg/ml, 10.85% hemolysis at 200¦Ìg/ml against rabbit red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22828809	Amino Acids. 2012 Jul 25.	"He X, Yang S, Wei L, Liu R, Lai R, Rong M."	"Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis."
DRAMP01879	GAFGDLLKGVAKEAGMKLLNMAQCKLSGKC	30	"Brevinin-2LTa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylarana latouchii (Broad-folded frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2 ?M), Bacillus licheniformis X39 (MIC=8 ?M), Staphylococcus carnosus KHS (MIC=2 ?M), Rhodococcus rhodochrous X15 (MIC=0.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=32.5 ?M), Serratia rubidaea X01 (MIC=130 ?M), Pseudomonas aeruginosa 1.50 (MIC=65 ?M), Psychrobacter faecalis X29 (MIC=0.5 ?M)."	[Ref.22426384] LD50=520 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys24 and Cys30)	Disulfide bond between Cys24 and Cys30.	L	No cytotoxicity information found	Not found	22426384	Biochimie. 2012 Jun;94(6):1317-1326.	"Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J."	"Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii."
DRAMP01880	SILDKIKNVALGVARGAGTGILKALLCKLDKSC	33	"Brevinin-2LTb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylarana latouchii (Broad-folded frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.8 ?M), Bacillus licheniformis X39 (MIC=3.8 ?M), Staphylococcus carnosus KHS (MIC=1.9 ?M), Rhodococcus rhodochrous X15 (MIC=1.9 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 ?M), Serratia rubidaea X01 (MIC=60 ?M), Pseudomonas aeruginosa 1.50 (MIC=30 ?M), Psychrobacter faecalis X29 (MIC=1.9 ?M)."	[Ref.22426384] LD50=480 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22426384	Biochimie. 2012 Jun;94(6):1317-1326.	"Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J."	"Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii."
DRAMP01881	GVLDTFKDVAIGVAKGAGTGVLKALLCKLDKSC	33	"Brevinin-2LTc (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylarana latouchii (Broad-folded frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=60 ?M), Rhodococcus rhodochrous X15 (MIC=30 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=15 ?M)."	[Ref.22426384] LD50>480 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22426384	Biochimie. 2012 Jun;94(6):1317-1326.	"Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J."	"Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii."
DRAMP01885	FFGPLIKIATGVLPNLICKALGKC	24	"Brevinin-1TEa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylarana temporalis (Indian bronzed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria.	"Gram-negative bacteria: E. coli (NCLM 2064) (MIC=30 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=150 ?g/ml), V. cholerae (PL 91) (MIC=150 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC=100 ?g/ml), S. aureus (ATCC25923) (MIC>150 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21412958	J Pept Sci. 2011 May;17(5):342-347.	"Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S."	Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae).
DRAMP01886	GIGSMLLGLAKNVGMSLLNKAQCKISGKC	29	"Brevinin-2TEa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylarana temporalis (Indian bronzed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria.	"Gram-negative bacteria: E. coli (NCLM 2064) (MIC=40 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=100 ?g/ml), V. cholerae (PL 91) (MIC=150 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC>150 ?g/ml), S. aureus (ATCC25923) (MIC>150 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21412958	J Pept Sci. 2011 May;17(5):342-347.	"Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S."	Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae).
DRAMP01887	GFMGDTLKGIARNAALALMNAAQCKLSGKC	30	"Brevinin-2TEb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Hylarana temporalis (Indian bronzed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria.	"Gram-negative bacteria: E. coli (NCLM 2064) (MIC=20 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=40 ?g/ml), V. cholerae (PL 91) (MIC=60 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC=150 ?g/ml), S. aureus (ATCC25923) (MIC=40 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21412958	J Pept Sci. 2011 May;17(5):342-347.	"Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S."	Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae).
DRAMP01888	FFPTIAGLTKLFCAITKKC	19	"Brevinin-1CHc (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana chiricahuensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: E. coli (MIC=80 ?M);##Gram-positive bacterium: S. aureus (MIC=20 ?M).##Yeast: C. albicans (MIC=20 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys13 and Cys19)	Disulfide bond between Cys13 and Cys19.	L	No cytotoxicity information found	Not found	21262304	Peptides. 2011 Apr;32(4):664-669.	"Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD."	Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona.
DRAMP01889	GIGSILGVIAKGLPTLISWIKNR	23	"Brevinin-1TOa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana tagoi okiensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: E. coli (MIC=20 ?M);##Gram-positive bacterium: S. aureus (MIC=5 ?M).##Yeast: C. albicans (MIC=20 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19799928	Toxicon. 2010 Feb-Mar;55(2-3):430-435.	"Conlon JM, Coquet L, Jouenne T, Leprince J, Vaudry H, Iwamuro S."	Evidence from the primary structures of dermal antimicrobial peptides that Rana tagoi okiensis and Rana tagoi tagoi (Ranidae) are not conspecific subspecies.
DRAMP01890	FLGAIAGVAAKFLPKVFCFITKKC	24	"Brevinin-1VLa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana vaillanti (Central American frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Brevinin-1VLa showes particularly high growth-inhibitory potency (MIC < or =3 microM) against a Gram-positive microorganism Staphylococcus aureus and the opportunistic yeast pathogen Candida albicans and potent cytolytic activity (LC(50)< or =8 microM) against both human erythrocytes and HepG2 hepatoma-derived cells. The peptide ia also active against a Gram-negative microorganism Escherichia coli (MIC< or =50 microM).	Gram-negative bacterium: E. coli (MIC=25 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M).	[Ref.19379837] LC50=8 mM against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	[Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells	Not found	19379837	Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154.	"Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)."
DRAMP01891	FLPVIASVAAKVLPKVFCFITKKC	24	"Brevinin-1VLc (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana vaillanti (Central American frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Brevinin-1VLc showes particularly high growth-inhibitory potency (MIC < or =3 microM) against a Gram-positive microorganism Staphylococcus aureus and the opportunistic yeast pathogen Candida albicans and potent cytolytic activity (LC(50)< or =8 microM) against both human erythrocytes and HepG2 hepatoma-derived cells. The peptide ia also active against a Gram-negative microorganism Escherichia coli (MIC< or =50 microM).	Gram-negative bacterium: E. coli (MIC=50 ?M);##Gram-positive bacterium: S. aureus (MIC=1.5 ?M).##Yeast: C. albicans (MIC=3 ?M).	[Ref.19379837] LC50=7 mM against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	[Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells	Not found	19379837	Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154.	"Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)."
DRAMP01892	FLPLIAGVAANFLPKIFCLISKKC	24	"Brevinin-1VLd (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana vaillanti (Central American frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells"	Gram-negative bacterium: E. coli (MIC>100 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M).	[Ref.19379837] LC50=5 mM against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	[Ref.19379837] LC50=6mM against HepG2 hepatoma-derived cells	Not found	19379837	Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154.	"Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)."
DRAMP01893	FLPLIAGVAASILPKIFCFITKKC	24	"Brevinin-1VLe (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana vaillanti (Central American frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells"	Gram-negative bacterium: E. coli (MIC>100 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M).	[Ref.19379837] LC50=5 mM against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	[Ref.19379837] LC50=7mM against HepG2 hepatoma-derived cells	Not found	19379837	Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154.	"Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)."
DRAMP01896	FLSTALKVAANVVPTLFCKITKKC	24	"Brevinin-1CG1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Amolops chunganensis (Chungan torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=9 ?M), Bacillus licheniformis X39 (IS) (MIC=75 ?M);##Gram-negative bacterium: Escherichia coli (ATCC 25922) (MIC=150 ?M).##Fungi: Slime mold 090223 (IS) (MIC=75 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22951323	Peptides. 2012 Nov;38(1):41-53.	"Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H."	Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis.
DRAMP01897	FLPIVAGLAANFLPKIVCKITKKC	24	"Brevinin-1CG2 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Amolops chunganensis (Chungan torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=9 ?M), Bacillus licheniformis X39 (IS) (MIC=75 ?M), Enterococcus faecalis 981 (MIC=19 ?M), Staphylococcus carnosus KHS (IS) (MIC=9 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=19 ?M), Serratia rubidaea X01 (IS) (MIC=19 ?M).##Fungi: Slime mold 090223 (IS) (MIC=4.5 ?M), Candida albicans (ATCC 10231) (MIC=150 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22951323	Peptides. 2012 Nov;38(1):41-53.	"Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H."	Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis.
DRAMP01898	FLSTLLNVASNVVPTLICKITKKC	24	"Brevinin-1CG3 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Amolops chunganensis (Chungan torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Primarily active against Gram-positive bacteria. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea.	"Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=2.3 ?M), Bacillus licheniformis X39 (IS) (MIC=9 ?M), Enterococcus faecalis 981 (MIC=75 ?M), Staphylococcus carnosus KHS (IS) (MIC=19 ?M), Staphylococcus aureus (ATCC 25923) (MIC=19 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=4.5 ?M), Serratia rubidaea X01 (IS) (MIC=9 ?M).##Fungi: Slime mold 090223 (IS) (MIC=9 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22951323	Peptides. 2012 Nov;38(1):41-53.	"Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H."	Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis.
DRAMP01899	FLSTLLNVASKVVPTLFCKITKKC	24	"Brevinin-1CG4 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Amolops chunganensis (Chungan torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=2.3 ?M), Bacillus licheniformis X39 (IS) (MIC=9 ?M), Enterococcus faecalis 981 (MIC=9 ?M), Staphylococcus carnosus KHS (IS) (MIC=9 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli (ATCC 25922) (MIC=150 ?M), Pseudomonas aeruginosa 11053 (IS) (MIC=75 ?M), Psychrobacter faecalis X29 (IS) (MIC=9 ?M), Serratia rubidaea X01 (IS) (MIC=9 ?M).##Fungi: Slime mold 090223 (IS) (MIC=9 ?M), Candida albicans (ATCC 10231) (MIC=150 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22951323	Peptides. 2012 Nov;38(1):41-53.	"Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H."	Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis.
DRAMP01900	FLPMLAGLAANFLPKIVCKITKKC	24	"Brevinin-1CG5 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Amolops chunganensis (Chungan torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Primarily active against Gram-positive bacteria, escecially R. rhodochrous. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea."	"Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=0.6 ?M), Bacillus licheniformis X39 (IS) (MIC=2.3 ?M), Enterococcus faecalis 981 (MIC=9 ?M), Staphylococcus carnosus KHS (IS) (MIC=1.2 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=75 ?M), Pseudomonas aeruginosa (CGMCC 1.50) (MIC=75 ?M), Pseudomonas aeruginosa 11053 (IS) (MIC=75 ?M), Klebsiella pneumoniae 08040724 (IS) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=9 ?M), Serratia rubidaea X01 (IS) (MIC=4.6 ?M).##Fungi: Slime mold 090223 (IS) (MIC=4.5 ?M), Candida albicans (ATCC 10231) (MIC=437.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22951323	Peptides. 2012 Nov;38(1):41-53.	"Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H."	Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis.
DRAMP01910	GVITDALKGAAKTVAAELLRKAHCKLTNSC	30	"Brevinin-2GHb (AMP-2; Frogs, amphibians, animals)"	A0AEI5	Belongs to the frog skin active peptide family (Brevinin subfamily)	br2GHb	Rana guentheri (Gunther's frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide.
Tissue specificity: Expressed by the skin glands.
PTM: Problely contains one disulfide bond 24-30. "	"Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=16.5 ?g/ml), Bacillus subtilis ATCC 6633 (MIC>64 ?g/ml);##Gram-negative bacteria: Escherichia coli O111 (MIC=8.2 ?g/ml), Escherichia coli ATCC 25922 (MIC=8.2 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys24 and Cys30)	Disulfide bond between Cys24 and Cys30.	L	No cytotoxicity information found	Not found	16979798	Peptides. 2006 Dec;27(12):3077-3084.	"Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ."	Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri.
DRAMP01911	SIWEGIKNAGKGFLVSILDKVRCKVAGGCNP	31	"Brevinin-2GHc (AMP-4; Frogs, amphibians, animals)"	A0AEI6	Belongs to the frog skin active peptide family (Brevinin subfamily)	br2GHc	Rana guentheri (Gunther's frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide.
Tissue specificity: Expressed by the skin glands.
PTM: Problely contains one disulfide bond 24-30. "	"Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=9.8 ?g/ml), Bacillus subtilis ATCC 6633 (MIC>64 ?g/ml);##Gram-negative bacteria: Escherichia coli O111 (MIC=19.6 ?g/ml), Escherichia coli ATCC 25922 (MIC=9.8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys24 and Cys30.	L	No cytotoxicity information found	Not found	16979798	Peptides. 2006 Dec;27(12):3077-3084.	"Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ."	Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri.
DRAMP01913	FLPLLAGLAANFLPKIFCKITKKC	24	"Brevinin-1GRa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana grahami (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	16621155	Peptides. 2006 Sep;27(9):2111-2117.	" Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H. "	"Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami. "
DRAMP01914	GLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC	33	"Brevinin-2GRa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana grahami (Asian frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M).##Yeast: Candida albicans (MIC>100 ?M).	[Ref.16621155] LC50=140 ¦ÌM against human erythrocytes. 	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	16621155##17272268	Peptides. 2006 Sep;27(9):2111-2117.##Mol Cell Proteomics. 2007 May;6(5):882-894. 	"Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H.##Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	"Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami.##Anti-infection peptidomics of amphibian skin."
DRAMP01918	FLPLIAGLAANFLPKIFCAITKKC	24	"Brevinin-1PLb (Frogs, amphibians, animals)"	A7WNV3	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity.
Tissue specificity: Expressed by the skin glands."	Gram-positive bacterium: Staphylococcus aureus (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli(MIC=26 ?M).##Yeast: Candida albicans (MIC=6 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17698247##11087945	Peptides. 2007 Aug;28(8):1605-1610.##Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Zhou M, Wang L, Owens DE, Chen T, Walker B, Shaw C.##Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step shotgun cloning.##Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01919	FLPVIAGVAAKFLPKIFCAITKKC	24	"Brevinin-1PLc (Frogs, amphibians, animals)"	A7WNV4	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli(MIC=7 ?M).##Yeast: Candida albicans (MIC=8 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17698247##11087945	Peptides. 2007 Aug;28(8):1605-1610.##Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Zhou M, Wang L, Owens DE, Chen T, Walker B, Shaw C.##Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step shotgun cloning.##Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01920	FLPILAGLAAKIVPKLFCLATKKC	24	"Brevinin-1CSa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana cascadae (Cascades frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Brevinin-1CSa was strongly hemolytic against human erythrocytes. 	[Ref.17451843]Gram-negative bacterium: Escherichia coli (MIC=32 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M).	[Ref.17451843] LD50=5 ?M against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	17451843	Peptides. 2007 Jun;28(6):1268-1274.	"Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C."	Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.
DRAMP01922	GLFNVFKKVGKNVLKNVAGSLMDNLKCKVSGEC	33	"Brevinin-2SKb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sakuraii (Japanese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17174009	Peptides. 2007 Mar;28(3):505-514.	"Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM."	Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.
DRAMP01933	GIMDTLKNLAKTAGKGALQSLVKMASCKLSGQC	33	"Brevinin-2Ef (Frogs, amphibians, animals)"	P40842	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity "	[Swiss_Prot Entry P40842]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.8163497]LC50>100 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01934	GILSTIKDFAIKAGKGAAKGLLEMASCKLSGQC	33	"Brevinin-2Ei (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta complex	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans.
Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide."	Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14499272	Peptides. 2003 Jul;24(7):955-961.	"Ali MF, Knoop FC, Vaudry H, Conlon JM."	Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex.
DRAMP01935	GIFLDKLKNFAKGVAQSLLNKASCKLSGQC	30	"Brevinin-2Ej (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta complex	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans.
Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide."	Gram-negative bacterium: Escherichia coli (MIC=2 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14499272	Peptides. 2003 Jul;24(7):955-961.	"Ali MF, Knoop FC, Vaudry H, Conlon JM."	Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex.
DRAMP01937	GLGSILGKILNVAGKVGKTIGKVADAVGNKE	31	"CPRF-Ea (caerulein precursor-related fragment; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana esculenta complex	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans.
Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide."	Gram-negative bacterium: Escherichia coli (MIC=4 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14499272	Peptides. 2003 Jul;24(7):955-961.	"Ali MF, Knoop FC, Vaudry H, Conlon JM."	Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex.
DRAMP01938	GLGSFLKNAIKIAGKVGSTIGKVADAIGNKE	31	"CPRF-Eb (caerulein precursor-related fragment; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana esculenta complex	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans.
Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide."	Gram-negative bacterium: Escherichia coli (MIC=5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14499272	Peptides. 2003 Jul;24(7):955-961.	"Ali MF, Knoop FC, Vaudry H, Conlon JM."	Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex.
DRAMP01939	GLGSFFKNAIKIAGKVGSTIGKVADAIGNKE	31	"CPRF-Ec (caerulein precursor-related fragment; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana esculenta complex	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans.
Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide."	Gram-negative bacterium: Escherichia coli (MIC=4 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14499272	Peptides. 2003 Jul;24(7):955-961.	"Ali MF, Knoop FC, Vaudry H, Conlon JM."	Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex.
DRAMP01940	FLPIIAGVAAKVLPKLFCAITKKC	24	"Brevinin-1CHa (Frogs, amphibians, animals)"	A7YJE2	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana chiricahuensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	PTM: Contains disulfide bond.	"Gram-negative bacteria: E. coli (MIC=10 ?M), K. pneumoniae (MIC=40 ?M), P. aeruginosa (MIC=20 ?M);##Gram-positive bacterium: S. aureus (MIC=2.5 ?M).##Yeast: C. albicans (MIC=2.5 ?M).(Ref.2)"	[Ref.21262304] LC50=5 ?M against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	17938991##21262304	J Mol Evol. 2007 Nov;65(5):605-615.##Peptides. 2011 Apr;32(4):664-669.	"Tennessen JA, Blouin MS.##Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD."	Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.##Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona.
DRAMP01941	FLPVIAGLAAKVLPKLFCAITKKC	24	"Brevinin-1CHb (Frogs, amphibians, animals)"	A7YJE4	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana chiricahuensis 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	PTM: Contains disulfide bond.	"Gram-negative bacteria: E. coli (MIC=10 ?M), K. pneumoniae (MIC=40 ?M), P. aeruginosa (MIC=10 ?M);##Gram-positive bacterium: S. aureus (MIC=2.5 ?M).##Yeast: C. albicans (MIC=2.5 ?M).(Ref.2)"	[Ref.21262304] LC50=5 ?M against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	17938991##21262304	J Mol Evol. 2007 Nov;65(5):605-615.##Peptides. 2011 Apr;32(4):664-669.	"Tennessen JA, Blouin MS.##Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD."	Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.##Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona.
DRAMP01942	FLPAIVGAAGQFLPKIFCAISKKC	24	"Brevinin-1Sa (Frogs, amphibians, animals)"	P82904	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sphenocephala (Southern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=55 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10604597	J Pept Res. 1999 Dec;54(6):522-527.	"Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC."	"Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala."
DRAMP01943	FLPAIVGAAGKFLPKIFCAISKKC	24	"Brevinin-1Sb (Frogs, amphibians, animals)"	P82905	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sphenocephala (Southern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=17 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10604597	J Pept Res. 1999 Dec;54(6):522-527.	"Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC."	"Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala."
DRAMP01944	FFPIVAGVAGQVLKKIYCTISKKC	24	"Brevinin-1Sc (Frogs, amphibians, animals)"	P82906	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sphenocephala (Southern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=14 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10604597	J Pept Res. 1999 Dec;54(6):522-527.	"Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC."	"Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala."
DRAMP01949	FLPAVLRVAAKIVPTVFCAISKKC	24	"Brevinin-1HSa (Frogs, amphibians, animals)"	P0C8S7	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana hosii (Hose's rock frog) (Odorrana hosii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 18-24."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=24 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01950	FLPAVLRVAAQVVPTVFCAISKKC	24	"Brevinin-1HSb (Brevinin-1JDb; Frogs, amphibians, animals)"	P0C8S8	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana hosii (Hose's rock frog) (Odorrana hosii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 18-24."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC>48 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01951	FMGGLIKAATKIVPAAYCAITKKC	24	"Brevinin-1PTa (Frogs, amphibians, animals)"	P0C8T1	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana picturata (Malaysian fire frog) (Hylarana picturata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 18-24."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=24 ?M).	 	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01953	GLLDSLKNLAINAAKGAGQSVLNTLSCKLSKTC	33	"Brevinin-2HSa (Frogs, amphibians, animals)"	P0C8S9	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hosii (Hose's rock frog) (Rana hosii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 27-33."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=36 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01955	GAIKDALKGAAKTVAVELLKKAQCKLEKTC	30	"Brevinin-2PTa (Frogs, amphibians, animals)"	P0C8T3	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana picturata (Malaysian fire frog) (Hylarana picturata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 24-30."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys24 and Cys30)	Disulfide bond between Cys24 and Cys30.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01956	GFKGAFKNVMFGIAKSAGKSALNALACKIDKSC	33	"Brevinin-2PTb (Frogs, amphibians, animals)"	P0C8T4	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana picturata (Malaysian fire frog) (Hylarana picturata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 27-33."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=9 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01957	GLLDSFKNAMIGIAKSAGKTALNKIACKIDKTC	33	"Brevinin-2PTc (Frogs, amphibians, animals)"	P0C8T5	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana picturata (Malaysian fire frog) (Hylarana picturata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 27-33."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>72 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01959	GFLDSFKNAMIGVAKSVGKTALSTLACKIDKSC	33	"Brevinin-2PTe (Frogs, amphibians, animals)"	P0C8T7	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana picturata (Malaysian fire frog) (Hylarana picturata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 27-33."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=36 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01963	FLPAIVGAAAKFLPKIFCAISKKC	24	"Brevinin-1BLa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates blairi (plains leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus"	[Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=1.5 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=25 ¦ÌM);##Fungi : Candida albicans(MIC=6 ¦ÌM)	[Ref.19254736] LC50=14 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19254736	Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.	"Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis."
DRAMP01965	FLPIIAGIAAKFLPKIFCTISKKC	24	"Brevinin-1BLc (Frogs, amphibians, animals)"	B6CPR0	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates blairi (leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	[Ref.19254736]Gram-negative bacterium:?Escherichia coli (MIC=25 ?M);##Gram-positive bacterium:?Staphylococcus aureus (MIC=1.5 ?M);##Yeast:?Candida albicans (MIC=3 ?M);##Cancer cells HepG2:?(LC50=6 ?M)..	[Ref.19254736] LC50=9 ¦ÌM against human red blood cells.##[Ref.14531844]Non-hemolytic activity against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19254736	Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.	"Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis."
DRAMP01968	FLPIIAGAAAKVVEKIFCAISKKC	24	"Brevinin-1Yc (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates yavapaiensis (North American leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	[Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=6 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=100 ¦ÌM);##Fungi : Candida albicans(MIC=6 ¦ÌM)Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).##Yeast: Candida albicans (MIC=6 ?M).##cancer cells HepG2 (LC50=14 ?M). 	[Ref.19254736] LC50=13 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19254736	Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.	"Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis."
DRAMP01969	FLGSLIGAAIPAIKQLLGLKK	21	"Brevinin-1Ja (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana japonica (Japanese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	It can produced cell death of mammalian COS7 cells (LD50=28 ?M).	Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=119 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18558801	Zoolog Sci 2008; 25: 487-491.	"Koyama T, Iwamuro S."	"Molecular cloning of a cDNA encoding atypical antimicrobial and cytotoxic brevinin-1Ja from the skin of the Japanese brown frog, Rana japonica."
DRAMP01970	FLPFLLSALPKVFCFFSKKC	20	"Brevinin-1ZHa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana zhenhaiensis (Chinese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=32 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>43 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22943778	Zoolog Sci. 2012 Sep;29(9):553-558.	"Xu B, Che H, Kang L, Zheng S, Mu S, Wan F."	"Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis."
DRAMP01971	FLPLLLSALPSFLCLVFKKC	20	"Brevinin-1ZHb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana zhenhaiensis (Chinese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=33 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC>44 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>44 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22943778	Zoolog Sci. 2012 Sep;29(9):553-558.	"Xu B, Che H, Kang L, Zheng S, Mu S, Wan F."	"Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis."
DRAMP01974	GIMRVFKGVLKTAGKSVAKNVAGSFLDRLKCKISGGC	37	"Brevinin-2ZHa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana zhenhaiensis (Chinese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=5 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22943778	Zoolog Sci. 2012 Sep;29(9):553-558.	"Xu B, Che H, Kang L, Zheng S, Mu S, Wan F."	"Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis."
DRAMP01986	SLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC	33	"Brevinin-2HS2 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Huia schmackeri (Chinese piebald odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: It shows poor hemolycity activity (LC50=300 uM). 	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 ?M), Bacillus licheniformis X39 (MIC=39 ?M), Rhodococcus rhodochrous X15 (MIC=9.5 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 ?M).##Fungi: Slime mould 090223 (MIC=37.5 ?M), Candida albicans ATCC2002 (MIC=19 ?M)."	LC50=300?M against human erythrocytes	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	18423796	Peptides. 2008 Aug;29(8):1456-1460.	"Quan Z, Zhou M, Chen W, Chen T, Walker B, Shaw C."	Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors.
DRAMP01990	FMGSALRIAAKVLPAALCQIFKKC	24	"Brevinin-1LT1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Hylarana latouchii (Chinese broad-folded frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity against rabbit red blood cells."	"[Ref.19340924]Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 ?M), Bacillus subtilis (MIC=6.25 ?M);##Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 ?M);##Yeast: Candida albicans (MIC=50 ?M)."	[Ref.19340924]LC50>200 ?g/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19340924	Biochimie. 2009 Apr;91(4):540-547.	"Wang H, Yan X, Yu H, Hu Y, Yu Z, Zheng H, Chen Z, Zhang Z, Liu J."	"Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae)."
DRAMP01994	SLLDTFKNLAVNAAKSAGVSVLNALSCKISRTC	33	"Brevinin-2ISa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana ishikawae (Endangered frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity.	"Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ?M), S. aureus (MRSA) (MIC=100 ?M), Bacillus subtilis (MIC=12.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP01995	SFLTTFKDLAIKAAKSAGQSVLSTLSCKLSNTC	33	"Brevinin-2ISb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana ishikawae (Endangered frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial activity.	"Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), Bacillus subtilis (MIC=25 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP01996	SVLGTVKDLLIGAGKSAAQSVLTTLSCKLSNSC	33	"Brevinin-2ISc (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana ishikawae (Endangered frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21193000	Peptides. 2011 Apr;32(4):670-676. 	"Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M."	Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.
DRAMP02001	FLPLIASLAANFVPKIFCKITKKC	24	"Brevinin-1HN1 (Frogs, amphibians, animals)"	E7EKC4	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hainanensis (Hainan odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P. faecalis. Has hemolytic activity against human erythrocytes (LC50=75 ?M).

Tissue specificity: Expressed by the skin glands.

PTM: Contains one disulfide bond."	"[Ref.22450466]Gram-positive bacteria: Enterococcus faecium 091299 (MIC=19 ?M), Enterococcus faecalis 981 (MIC=19 ?M), Staphylococcus aureus ATCC2592 (MIC=1.2 ?M), Staphylococcus carnosus KHS (MIC=4.8 ?M), Bacillus licheniformis X39 (MIC=2.4 ?M), Rhodococcus rhodochrous X15 (MIC=1.2 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=150 ?M), Psychrobacter faecalis X29 (MIC=4.8 ?M);##Fungi: Slime mould 090223 (MIC=1.2 ?M), Candida albicans ATCC2002 (MIC=2.4 ?M)."	[Ref.22450466] LC50=75 ?M against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22450466	Peptides. 2012 Jun;35(2):285-290.	"Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J."	"Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis."
DRAMP02004	FLPLIASVAANLVPKIFCKITKKC	24	"Brevinin-1V (Frogs, amphibians, animals)"	"Q2UXV8, E7EKC5"	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana versabilis (Chinese bamboo leaf odorous frog) (Rana versabilis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P. faecalis. Has hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond."	"[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 ?M), Bacillus licheniformis X39 (MIC=37.5 ?M), Rhodococcus rhodochrous X15 (MIC=9.5 ?M), Enterococcus faecium 091299 (MIC=19 ?M), E. faecalis 981 (MIC=19 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 ?M);##Fungi: Slime mould 090223 (MIC=1.2 ?M), Candida albicans ATCC2002 (MIC=19-37.5 ?M)."	[Ref.22450466] LC50=75 ?M against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	16139929##22450466	Peptides. 2006 Jan;27(1):42-48.##Peptides. 2012 Jun;35(2):285-290.	"Chen T, Li L, Zhou M, Rao P, Walker B, Shaw C.##Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J."	"Amphibian skin peptides and their corresponding cDNAs from single lyophilized secretion samples: identification of novel brevinins from three species of Chinese frogs.##Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis."
DRAMP02006	GIWDTLKNVGKAVLGKVLENV	21	"Brevinin-2Va (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana virgatipes (Ranidae) (Aquarana)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=12 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15996769	Regul Pept. 2005 Nov;131(1-3):38-45.	"Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR."	"Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). "
DRAMP02009	FLPVLAGIAAKVVPALFCKITKKC	24	"Brevinin-1 (Frogs, amphibians, animals)"	P32423	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana brevipoda porsa (Japanese frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity."	[Ref.1449472]Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=34 ?g/ml).	[Ref.1449472] high hemolytic activity	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	1449472	Biochem Biophys Res Commun. 1992 Nov 30;189(1):184-190.	"Morikawa N, Hagiwara K, Nakajima T."	"Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa."
DRAMP02010	GLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC	33	"Brevinin-2 (Frogs, amphibians, animals)"	P32424	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana brevipoda porsa (Japanese frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity."	[Ref.1449472]Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=4 ?g/ml).	[Ref.1449472] high hemolytic activity	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	1449472	Biochem Biophys Res Commun. 1992 Nov 30;189(1):184-190.	"Morikawa N, Hagiwara K, Nakajima T."	"Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa."
DRAMP02019	GLFDVVKGVLKGAGKNVAGSLLEQLKCKLSGGC	33	"Brevinin-2DYb (Frogs, amphibians, animals)"	P0C5X2	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 27-33."	Gram-positive bacterium: Staphylococcus aureus (MIC=30 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	17688900	Toxicon. 2007 Nov;50(6):746-756.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S."	"Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii."
DRAMP02023	GIFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC	33	"Brevinin-2DYd (Frogs, amphibians, animals)"	P0C5X4	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 27-33."	Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15 ?M).##NOTE: mixture of Brevinin-2DYc/2DYd	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	17688900	Toxicon. 2007 Nov;50(6):746-756.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S."	"Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii."
DRAMP02025	GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKISGGC	37	"Brevinin-2DYe (Brevinin-2CDYa; Frogs, amphibians, animals)"	P0C5X5	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Active against the Gram-positive bacteria: S. aureus and Gram-negative bacteria E. coli. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 31-37.	Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	17688900##17698251	Toxicon. 2007 Nov;50(6):746-756.##Peptides. 2007 Aug;28(8):1532-1539.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S.##Kim SS, Shim MS, Chung J, Lim DY, Lee BJ."	"Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii.##Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii."
DRAMP02026	LLSLALAALPKLFCLIFKKC	20	"Brevinin-1CDYa (Frogs, amphibians, animals)"	B3VZU0	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has low activity against the Gram-positive bacteria: S. aureus and Gram-negative bacteria E. coli. Has hemolytic activity against human erythrocytes (HC50=125 ?M).
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 14-20."	[Swiss_Prot Entry B3VZU0]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25 ?M)	[Ref.19539775]HC50=125 ¦ÌM against human red blood cells	Cyclic	Free	Cyclization (Cys14 and Cys20)	Disulfide bond between Cys14 and Cys20.	L	No cytotoxicity information found	Not found	19539775	Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.	"Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH."	"Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii."
DRAMP02031	ILPLLLGKVVCAITKKC	17	"Brevinin-1Da (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dalmatina (European frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Sequence alignment suggests that the peptide is derived from brevinin-1 by multiple residue deletions (D for ""dalmatina"" and 'a' to denote the first isoform identified). "	Gram-positive bacterium: Staphylococcus aureus (MIC=7 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys11 and Cys17)	Disulfide bond between Cys11 and Cys17.	L	No cytotoxicity information found	Not found	15050930	Comp Biochem Physiol C Toxicol Pharmacol. 2004 Feb;137(2):191-196.	"Conlon JM, Seidel B, Nielsen PF."	An atypical member of the brevinin-1 family of antimicrobial peptides isolated from the skin of the European frog Rana dalmatina.
DRAMP02032	FLGSIVGALASALPSLISKIRN	22	"Brevinin-1TSa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana tsushimensis (Tsushima brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Activity against a range of Gram-positive and Gram-negative bacteria, but hemolytic activity against human erythrocytes."	"[Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Klebsiella pneumoniae KK3 9904 (MIC>100 ?M), Enterobacter cloacae HNTCC 53001 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=50 ?M), Proteus mirabilis ATCC 25933 (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=25 ?M), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 ?M), Staphylococcus epidermidis RP62A (MIC=12.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=50 ?M), Streptococcus group B HNTCC 80130 (MIC=50 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=50 ?M)"	[Ref.16413829]LD50=12 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16413829	Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. 	"Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S."	Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis.
DRAMP02033	GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC	33	"Brevinin-2TSa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana tsushimensis (Tsushima brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Activity against a range of Gram-positive and Gram-negative bacteria, but relatively low hemolytic activity against human erythrocytes."	"[Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Klebsiella pneumoniae KK3 9904 (MIC=6 ?M), Enterobacter cloacae HNTCC 53001 (MIC=6 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=6 ?M), Proteus mirabilis ATCC 25933 (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=12.5 ?M), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 ?M), Staphylococcus epidermidis RP62A (MIC=12.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=25 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=100 ?M)."	[Ref.16413829] LD50=100 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	16413829	Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. 	"Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S."	Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis.
DRAMP02034	FLPILAGLAAKLVPKVFCSITKKC	24	"Brevinin-1AUa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana aurora aurora (Northern red-legged frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Activity against a range of Gram-positive and Gram-negative bacteria, and also shows hemolytic. "	"[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=13 ?M), Pseudomonas aeruginosa (MIC=25 ?M), Enterobacter cloacae (MIC=13 ?M), Klebsiella pneumoniae (MIC=50 ?M), Proteus mirabilis (MIC>50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Staphylococcus epidermidis (MIC=6 ?M), Enterococcus faecalis (MIC=13 ?M), Streptococcus Group B (MIC=13 ?M);##Yeast: Candida albicans (MIC>40 ?M)."	[Ref.15325526] HC50=5 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	15325526	Dev Comp Immunol. 2005;29(1):83-90.	"Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T."	Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora.
DRAMP02035	FLPILAGLAANILPKVFCSITKKC	24	"Brevinin-1AUb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana aurora aurora (Northern red-legged frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Activity against a range of Gram-positive and Gram-negative bacteria, and also shows hemolytic activity. "	"[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=25 ?M), Pseudomonas aeruginosa (MIC=25 ?M), Enterobacter cloacae (MIC=25 ?M), Klebsiella pneumoniae (MIC>50 ?M), Proteus mirabilis (MIC>50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Staphylococcus epidermidis (MIC=6 ?M), Enterococcus faecalis (MIC=6 ?M), Streptococcus Group B (MIC=13 ?M);##Yeast: Candida albicans (MIC=3 ?M)."	[Ref.15325526] HC50=7 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	15325526	Dev Comp Immunol. 2005;29(1):83-90.	"Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T."	Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora.
DRAMP02036	GAFGNFLKGVAKKAGLKILSIAQCKLSGTC	30	"Brevinin-2-RN1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana nigrovittata	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Brevinin-2-RN1 and -RN2 could induce 17 and 21% Rabbit red blood cell hemolysis, respectively."	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.10 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=3.10 ?g/ml), Bacillus subtilis (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=6.25 ?g/ml)."	[Ref.21171145] It has 17% hemolysis at 100 ?g/ml against rabbit red blood cell	Cyclic	Free	Cyclization (Cys24 and Cys30)	Disulfide bond between Cys24 and Cys30.	L	No cytotoxicity information found	Not found	21171145	J Pept Sci. 2011 Jan;17(1):68-72.	"Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R."	"Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata."
DRAMP02037	GAFGNFLKGVAKKAGLKILSIAQCKLFGTC	30	"Brevinin-2-RN2 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana nigrovittata	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Brevinin-2-RN1 and -RN2 could induce 17 and 21% Rabbit red blood cell hemolysis, respectively."	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=6.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 ?g/ml), Bacillus subtilis (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=50 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=12.5 ?g/ml). Yeast: Candida albicans ATCC2002 (MIC=3.1 ?g/m)."	[Ref.21171145] It has 21% hemolysis at 100 ?g/ml against rabbit red blood cell	Cyclic	Free	Cyclization (Cys24 and Cys30)	Disulfide bond between Cys24 and Cys30.	L	No cytotoxicity information found	Not found	21171145	J Pept Sci. 2011 Jan;17(1):68-72.	"Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R."	"Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata."
DRAMP02038	VIVFVASVAAEMMQHVYCAASKKC	24	"Brevinin-1-OA1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 ?g/ml);##Gram-negative bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml), Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml).##Yeast: Candida albicans (MIC=24.8 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02040	FLPAVIRVAANVLPTAFCAISKKC	24	"Brevinin-1-OA12 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.2 ?g/ml).##Yeast: Candida albicans (MIC=3.3 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02041	LPFVAGVAAEMMQHVYCAASKKC	23	"Brevinin-1-OR1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=42.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.6 ?g/ml).##Yeast: Candida albicans (MIC=10.6 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys17 and Cys23)	Disulfide bond between Cys17 and Cys23.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02042	IDPFVAGVAAEMMQHVYCAASKKC	24	"Brevinin-1-OR3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=9.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=18.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18.2 ?g/ml).##Yeast: Candida albicans (MIC=18.2 ?g/ml). "	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02043	INPFVAGVAAEMMQHVYCAASKKC	24	"Brevinin-1-OR4 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml).##Yeast: Candida albicans (MIC=8.6 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02044	ILPFVAGVAAEMMKHVYCAASKKC	24	"Brevinin-1-OR5 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	It differs from AP1824 only at position 14: Q vs. K.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.2 ?g/ml).##Yeast: Candida albicans (MIC=7.6 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02045	IIPFVAGVAAEMMEHVYCAASKKC	24	"Brevinin-1-OR6 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	It differs from AP1827 at two positions: 2: I vs. L and 14: K vs. E.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.2 ?g/ml).##Yeast: Candida albicans (MIC=11.1 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02046	QLPFVAGVACEMCQCVYCAASKKC	24	"Brevinin-1-OR7 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=5.7 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.4 ?g/ml).##Yeast: Candida albicans (MIC=11.4 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02047	ILPFVAGVAAEMMEHVYCAASKKC	24	"Brevinin-1-OR8 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=52.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=26.2 ?g/ml).##Yeast: Candida albicans (MIC=13.1 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02048	ILPFVAGVAAMEMEHVYCAASKKC	24	"Brevinin-1-OR9 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=9.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=9.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.9 ?g/ml).##Yeast: Candida albicans (MIC=9.8 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02049	FLPAVLLVATHVLPTVFCAITRKC	24	"Brevinin-1-OR10 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=27.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.8 ?g/ml).##Yeast: Candida albicans (MIC=6.8 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02050	LAFVAGVAAEMMQHVYCAASKKC	23	"Brevinin-1-OR11 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 ?g/ml).##Yeast: Candida albicans (MIC=12.4 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys17 and Cys23)	Disulfide bond between Cys17 and Cys23.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02051	ILPFVAGVAAEMMQHVYCAASKKC	24	"Lividin-1 (Brevinin-1-OR2; Frogs, amphibians, animals)"	Q2UXR4	Belongs to the frog skin active peptide family (Brevinin subfamily)	lividin-1	Odorrana rotodora (Chinese odorous frog) (Odorrana livida)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Amphibian defensive peptide.
Tissue specificity: Expressed by the skin glands.
PTM: Contains disulfide bond."	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 ?g/ml).##Yeast: Candida albicans (MIC=5.8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	16713657##22029824	Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319.	"Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y."	"Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs."
DRAMP02052	SFLDTLKNLAISAAKGAGQSVLSTLSCKLSKTC	33	"Lividin-2 (Brevinin-2-OR8; Frogs, amphibians, animals)"	Q2UXR3	Belongs to the frog skin active peptide family (Brevinin subfamily)	lividin-2	Odorrana rotodora (Chinese odorous frog) (Odorrana livida)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Amphibian defensive peptide.
Tissue specificity: Expressed by the skin glands.
PTM: Contains disulfide bond."	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=13.1 ?g/ml).##Yeast: Candida albicans (MIC=13.1 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	16713657##22029824	Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319.	"Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y."	"Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs."
DRAMP02053	SVLGTVKDLLIGAGKSAAQSVLTALSCKLSNSC	33	"Lividin-3 (Brevinin-2-OR1; Frogs, amphibians, animals)"	Q2UXR2	Belongs to the frog skin active peptide family (Brevinin subfamily)	lividin-3	Odorrana rotodora (Chinese odorous frog) (Odorrana livida)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Amphibian defensive peptide.
Tissue specificity: Expressed by the skin glands.
PTM: Contains disulfide bond."	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11 ?g/ml).##Yeast: Candida albicans (MIC=11 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	16713657##22029824	Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319.	"Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y."	"Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs."
DRAMP02054	GILDTFKNMALNAAKSAGVSVLNALSCKLSKTC	33	"Brevinin-2-OA1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.1 ?g/ml).##Yeast: Candida albicans (MIC=6.0 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02055	GLLDTFKNMALNAAKSAGVSVLNALSCKLSKTC	33	"Brevinin-2-OA2 (Brevinin-2E-OG1; Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Found in multiple species.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml).##Yeast: Candida albicans (MIC=6.6 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02056	GLLDTFKNMAINAAHGAGVSVLNALSCKLKKTC	33	"Brevinin-2-OA3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml).##Yeast: Candida albicans (MIC=3.2 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02057	GLLDTFKNLAINAAESAGVSVLNSLSCKLSKTC	33	"Brevinin-2-OA4 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=10 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02058	GLLDGILNANFNAAKSAGTSVLNALSCKLSKTC	33	"Brevinin-2-OA5 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=30.6 ?g/ml).##Yeast: Candida albicans (MIC=30.6 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02059	GVLATVKNLLIGTGDGAAQSVLKTLSCKLSNDC	33	"Brevinin-2-OA6 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=44.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.4 ?g/ml).##Yeast: Candida albicans (MIC=11.2 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02060	GVLGTVKDLLIGAGKSAAQSTLKTLSCKISNDC	33	"Brevinin-2-OA7 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 ?g/ml).##Yeast: Candida albicans (MIC=5.8 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02061	GVLATVKNLLNGTGDGAAQSVLKTLSCKLSNDC	33	"Brevinin-2-OA8 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana andersonii (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.9 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.0 ?g/ml).##Yeast: Candida albicans (MIC=4.0 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02062	GLLDTIKNMALNAAKSAGVSVLNSLSCKLSKTC	33	"Brevinin-2-OR2 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.0 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.1 ?g/ml).##Yeast: Candida albicans (MIC=12.1 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02063	GLIDTIKNMALNAAKSAGVSVLNTLSCKLSKTC	33	"Brevinin-2-OR3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=41.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.6 ?g/ml).##Yeast: Candida albicans (MIC=10.3 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02064	SVLGTVKDLLIGAGKSAAQSVLTANSCKLSNSC	33	"Brevinin-2-OR4 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.9 ?g/ml).##Yeast: Candida albicans (MIC=11.8 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02065	SFLDTLKNLAISAAKGAGQSVLSTLSCKLSETC	33	"Brevinin-2-OR5 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml).##Fungi: Candida albicans (MIC=6.6 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02066	GLLDTIKNMALNAAKSAGVSVLNSLSCKDSKTC	33	"Brevinin-2-OR6 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.8 ?g/ml).##Fungi: Candida albicans (MIC=11.6 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02067	GLLDTIKNMALNAAKSAGVSVLNTLSCKLSKTC	33	"Brevinin-2-OR7 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml).##Fungi: Candida albicans (MIC=17.2 ?g/ml)"	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02068	SFLSTFKELAINAAKNAGQSILHTLSCKLDKTC	33	"Brevinin-2-OR9 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10.2 ?g/ml).##Fungi: Candida albicans (MIC=5.1 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02069	SFLSTFKELAINAAKNAGQSLLHTLSCKLDKTC	33	"Brevinin-2-OR10 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana rotodora (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: It differs from AP1850 only at position 21: L vs. I, so they are predicted to have essentially identical structure and activity."	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=7.9 ?g/ml).##Fungi: Candida albicans (MIC=15.8 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02070	SVMGTVKDLLIGAGKSAAQSVLKSLSCKISNDC	33	"Brevinin-2-OW1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana wuchuanensis (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.7 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=9.4 ?g/ml).##Fungi: Candida albicans (MIC=4.7 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02071	SVMGTVKDLLIGAGKSAAQSVLKSLSCKLSNDC	33	"Brevinin-2-OW2 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana wuchuanensis (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.3 ?g/ml).##Fungi: Candida albicans (MIC=3.3 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02072	SVMGTVKDLLIGAGKSAAQSVLKALSCKLSKDC	33	"Brevinin-2-OW3 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana wuchuanensis (Chinese odorous frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has antibacterial and antifungal activity. 	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.0 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.5 ?g/ml).##Fungi: Candida albicans (MIC=10.5 ?g/ml)."	[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 ¦Ìg/mL.	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319. 	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP02073	FLPAVIRVAANVLPTVFCAISKKC	24	"Brevinin-1JDa (Frogs, amphibians, animals)"	B3A0M4	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bonds."	"[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), S. aureus (MRSA) (MIC=32 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=128 ?g/ml);##Fungi: Candida albicans (MIC=128 ?g/ml)."	[Ref.22917879] It has 79.2 ¡À 6.8% hemolytic activity at 128 ¦Ìg/mL against rabbit red blood cells	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22917879	J Proteomics. 2012 Oct 22;75(18):5807-5821.	"Liu J, Jiang J, Wu Z, Xie F."	"Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data."
DRAMP02075	FLPAVLRVAAKVVPTVFCLISKKC	24	"Brevinin-1JDc (Frogs, amphibians, animals)"	B3A0N0	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bonds."	"[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), S. aureus (MRSA) (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=128 ?g/ml)."	[Ref.22917879] It has 11.7 ¡À 3.2% hemolytic activity at 64 ¦Ìg/mL and 88.4 ¡À 4.2% hemolytic activity at 128 ¦Ìg/mL against rabbit red blood cells	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	22917879	J Proteomics. 2012 Oct 22;75(18):5807-5821.	"Liu J, Jiang J, Wu Z, Xie F."	"Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data."
DRAMP01746	FVQWFSKFLGRIL	13	"Temporin-L (Temporin-1Tl; temporin-Tl; TL; Frogs, amphibians, animals)"	P57104	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic, Anti-cancer"	Protein level	Alpha helix	Not found	6GS5 resolved by NMR.	"Function: Antibacterial activity against Gram-negative and Gram-positive bacteria.
PTM: Leucine amide at position 13.
Tissue specificity: Expressed by the skin glands."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9022710	Eur J Biochem. 1996 Dec 15;242(3):788-792.	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D."	"Temporins, antimicrobial peptides from the European red frog Rana temporaria."
DRAMP02078	FLPVVAGLAAKVLPSIICAVTKKC	24	"Brevinin-1SY (Frogs, amphibians, animals)"	P82871	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sylvatica (Wood frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MIC=7 ?M);##Gram-negative bacterium: Escherichia coli (MIC=45 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11042268	FEBS Lett. 2000 Oct 20;483(2-3):135-138.	"Matutte B, Storey KB, Knoop FC, Conlon JM."	"Induction: of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli."
DRAMP04238	FFHLHFHY	8	PL-101	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria.	"[Ref.12569105] Gram-negative bacterium: Escherichia coli (MEC=7 ¦Ìg/ml), Pseudomonas aeruginosa (MEC=10 ¦Ìg/ml).;##Gram-positive bacteria: Staphylococcus aureus (MEC=3 ¦Ìg/ml), MRSA (MEC=4 ¦Ìg/ml) at PH 6.5."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12569105	J Biol Chem. 2003 Apr 11;278(15):13546-53.	"Tincu JA, Menzel LP, Azimov R, Sands J, Hong T, Waring AJ, Taylor SW, Lehrer RI."	"Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes."
DRAMP02778	AHCLAIGRK	9	"Defensin (Insects, animals)"	O96049	Belongs to the invertebrate defensin family (Type 1 subfamil	Not found	Oryctes rhinoceros (Coconut rhinoceros beetle)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	Function: Shows very strong activity against Staphylococcus aureus. Has no hemolytic activity.	"[Ref.10561605] Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus aureus (MRSA) (MIC>50 ?g/ml);## Gram-negative bacteria: Escherichia coli (MIC=25 ?g/ml), Pseudomonas aeruginosa (MIC>50 ?g/ml)."	[Ref.10561605] Had no hemolytic activity against rabbit erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10561605	Eur. J. Biochem. 1999;266:616-623.	"Ishibashi J, Yang J, Saido-Sakanaka H, Nakazawa H, Yamamoto M, Yamakawa M."	"Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros."
DRAMP02084	GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC	33	"Brevinin-2E (Frogs, amphibians, animals)"	P32413	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity."	"[Ref.8508915]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=2.0 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa ATCC 15692 (MIC>30 ?M)."	[Ref.8163497]LC50>100 ¦ÌM against human red blood cells	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	8508915	FEBS Lett. 1993 Jun 14;324(2):159-161.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta.
DRAMP02101	FLPLLAGVVANFLPQIICKIARKC	24	"Brevinin-1RTa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops ricketti (Chinese sucker frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells (LD50=100.0 ?g/ml) in vitro.
PTM: Contains one disulfide bond 27-33."	"[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=6.3 ?g/ml), Bacillus licheniformis X39 (MIC=25.0 ?g/ml), Rhodococcus rhodochrous X15 (MIC=3.1 ?g/ml);##Gram-negative bacteria: Serratia rubidaea X01 (MIC=NA ?g/ml), Pseudomonas aeruginosa 1.50 (MIC=NA ?g/ml), Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)."	[Ref.22100518]LD50=100 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22100518	Peptides. 2012 Jan;33(1):27-34.	"Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J."	Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae).
DRAMP02102	FLGSLLGLVGKVVPTLFCKISKKC	24	"Brevinin-1RTb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops ricketti (Chinese sucker frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells (LD50=200.0 ?g/ml) in vitro.
PTM: Contains one disulfide bond 27-33."	"[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.1 ?g/ml), Bacillus licheniformis X39 (MIC=25.0 ?g/ml), Staphylococcus carnosus KHS (MIC=12.5 ?g/ml), Rhodococcus rhodochrous X15 (MIC=3.1 ?g/ml);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)"	[Ref.22100518]LD50=200 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22100518	Peptides. 2012 Jan;33(1):27-34.	"Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J."	Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae).
DRAMP02104	GLMSTLKDFGKTAAKEIAQSLLSTASCKLAKTC	33	"Brevinin-2RTa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops ricketti (Chinese sucker frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells in vitro.
PTM: Contains one disulfide bond 27-33."	"[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=12.5 ?g/ml), Bacillus licheniformis X39 (MIC=50.0 ?g/ml), Staphylococcus carnosus KHS (MIC=6.3 ?g/ml), Rhodococcus rhodochrous X15 (MIC=1.6 ?g/ml);##Gram-negative bacteria: Serratia rubidaea X01 (MIC=100.0 ?g/ml), Psychrobacter faecalis X29 (MIC=6.3 ?g/ml)."	[Ref.22100518]LD50>400 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22100518	Peptides. 2012 Jan;33(1):27-34.	"Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J."	Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae).
DRAMP02105	GILDTLKEFGKTAAKGIAQSLLSTASCKLAKTC	33	"Brevinin-2RTb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Amolops ricketti (Chinese sucker frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Brevinin-2RTb has antibacterial activity and relatively low hemolytic activity (>400 ?g/ml) against rabbit red blood cells in vitro.
PTM: Contains one disulfide bond 27-33."	"[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=50.0 ?g/ml), Bacillus licheniformis X39 (MIC=200.0 ?g/ml), Staphylococcus carnosus KHS (MIC=100.0 ?g/ml), Rhodococcus rhodochrous X15 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)."	[Ref.22100518]LD50>400 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22100518	Peptides. 2012 Jan;33(1):27-34.	"Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J."	Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae).
DRAMP02114	AWLDKLKSLGKVVGKVALGVAQNYLNPQQ	29	"Raniseptin-1 (Rsp-1; Frogs, amphibians, animals)"	P86037	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	Not found	Hypsiboas raniceps (Chaco tree frog) (Hyla roeschmanni)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against Gram-negative as well as Gram-positive bacteria. And has hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the skin glands."	"[Ref.18976634]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=10 ?M), Xanthomonas citri (MIC<2 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 29313 (MIC=20 ?M)."	[Ref.18976634]20% hemolytic activity at 80 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18976634	Biochem Biophys Res Commun. 2008 Dec 26;377(4):1057-1061.	"Magalh?es BS, Melo JA, Leite JR, Silva LP, Prates MV, Vinecky F, Barbosa EA, Verly RM, Mehta A, Nicoli JR, Bemquerer MP, Andrade AC, Bloch C Jr."	Post-secretory events alter the peptide content of the skin secretion of Hypsiboas raniceps.
DRAMP02125	IFGAILPLALGALKNLIK	18	"Hylin-a1 (Hy-a1; Frogs, amphibians, animals)"	P85982	Not found	Not found	Hypsiboas albopunctatus (Spotted tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	2N0O resolved by NMR.	"Function: Has antibacterial activity against the Gram-positive bacteria and the Gram-negative bacteria. Has hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the skin glands."	"[Ref.19056441]Gram-positive bacteria: Staphylococcus aureus ATCC 25926 (MIC=8 ?M), Enterococcus faecalis ATCC 29212 (MIC=16 ?M), Bacillus subtilis ATCC 19659 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=32 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=64 ?M);##Fungi: Candida albicans ATCC 90028 (MIC=16.7 ?M), C. krusei ATCC 6258 (MIC=16.7 ?M), C. parapsilosis ATCC 22019 (MIC=67 ?M), Cryptococcus neoformans ATCC 90012 (MIC=33.5 ?M)"	[Ref.19056441]HC50=18 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19056441	Peptides. 2009 Feb;30(2):291-296.	"Castro MS, Ferreira TC, Cilli EM, Crusca E Jr, Mendes-Giannini MJ, Sebben A, Ricart CA, Sousa MV, Fontes W."	"Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus (spotted treefrog)."
DRAMP02127	GLLGGLLGPLLGGGGGGGGGLL	22	"Leptoglycin (Gly-rich; Frogs, amphibians, animals)"	P86267	Not found	Not found	Leptodactylus pentadactylus (Smokey jungle frog) (Rana pentadactyla)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial protein. Has antibacterial activity but not against Gram-positive bacteria Staphylococcus aureus, Micrococcus luteus and Enterococcus faecalis, yeasts Candida albicans and Candida tropicalis and dermatophytes fungi Microsporum canis and Trichophyton rubrum. No hemolytic activity was observed at the 2-200 microM range concentration.
Tissue specificity: Expressed by the skin glands."	"[Ref.19298834]Gram-negative bacteria: Escherichia coli ATCC 28922 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=8 ?M);##Fungi: Citrobacter freundii ATCC 8090 (MIC=75 ?M)"	[Ref.19298834]Non-hemolytic activity was observed at 2-200 ¦ÌM concentration	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19298834	Toxicon. 2009 Jul;54(1):23-32.	"Sousa JC, Berto RF, Gois EA, Fontenele-Cardi NC, Hon¨®rio JE Jr, Konno K, Richardson M, Rocha MF, Camargo AA, Pimenta DC, Cardi BA, Carvalho KM."	Leptoglycin: a new glycine/leucine-rich antimicrobial peptide isolated from the skin secretion of the South American frog Leptodactylus pentadactylus (Leptodactylidae).
DRAMP02129	FIKELLPHLSGIIDSVANAIK	21	"Kasstasin (Frogs, amphibians, animals)"	G0LWV9	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Kassina maculata (African rhacophorid frog) (Hylambates maculatus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Peptide with potent vasoconstrictor properties. Has moderate antimicrobial activity. Not active against fungus C. albicans. Has hemolytic activity against horse erythrocytes.
Tissue specificity: Expressed by the skin dorsal glands.
Miscellaneous: Kasstasin is a derivation of Kassina, the taxon of origin, and the Ancient Greek word 'stasis' meaning 'stoppage of flow'."	[Ref.21624426]Gram-positive bacterium: Staphylococcus aureus (MIC=55 ?M);##Gram-negative bacterium: Escherichia coli (MIC=110 ?M).	[Ref.21624426]12.8% hemolytic activity at 125 ¦ÌM against defibrinated horse blood	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21624426	Biochimie. 2011 Sep;93(9):1537-1542.	"Li X, Feng W, Zhou M, Ma C, Chen T, Zeller M, Hornshaw M, Wang L, Shaw C."	"Kasstasin: A novel potent vasoconstrictor peptide from the skin secretion of the African red-legged running frog, Kassina maculata."
DRAMP02130	GFLGPLLKLAAKGVAKVIPHLIPSRQQ	27	"Antimicrobial peptide 1 (XT-1; Frogs, amphibians, animals)"	P84387	Not found	Not found	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E.coli and stronger activity against yeast C. albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells .
Tissue specificity: Expressed by the skin glands."	[Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacteria: Escherichia coli (MIC=6 ?M);##Fungi: Candida albicans (MIC=50 ?M)	[Ref.11738090]HC50=90 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11738090	Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.	"Ali MF, Soto A, Knoop FC, Conlon JM."	"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)."
DRAMP02131	GVWSTVLGGLKKFAKGGLEAIVNPK	25	"Antimicrobial peptide 2 (XT-2; Frogs, amphibians, animals)"	P84382	Not found	Not found	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has very strong antibacterial activity against Gram-positive bacterium S. aureus and very weak activity against Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin glands."	Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria: Escherichia coli (MIC=8 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11738090	Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.	"Ali MF, Soto A, Knoop FC, Conlon JM."	"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)."
DRAMP02133	GVFLDALKKFAKGGMNAVLNPK	22	"Antimicrobial peptide 4 (XT-4; Frogs, amphibians, animals)"	P84384	Not found	Not found	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and yeast C. albicans, and very weak activity against Gram-negative bacterium E.coli. Has strong hemolytic activity against human red blood cells.
Tissue specificity: Expressed by the skin glands."	[Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria: Escherichia coli (MIC=18 ?M);##Fungi: Candida albicans (MIC>100 ?M).	[Ref.11738090]HC50>150 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11738090	Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.	"Ali MF, Soto A, Knoop FC, Conlon JM."	"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)."
DRAMP02135	GFLGSLLKTGLKVGSNLL	18	"Antimicrobial peptide 6 (XT-6; Frogs, amphibians, animals)"	P84386	Not found	Not found	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E.coli and strong activity against yeast C. albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells.
Tissue specificity: Expressed by the skin glands."	"[Ref.11738090]Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=5 ?M);##Yeast: Candida albicans (MIC=40 ?M);##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 ?M), Staphylococcus aureus (MRSA) (MIC=7 ?M), Staphylococcus epidermidis 1420129 (MIC=3 ?M), S. saprophyticus 1950556 (MIC=13 ?M), Escherichia coli 25922 (MIC=6 ?M), Streptococcus group C 1541035 (MIC=3 ?M), Shigella sonnei 1840187 (MIC=35 ?M), Pseudomonas aeruginosa 0380972 (MIC=60 ?M), Enterobacter cloacae 1441323 (MIC=35 ?M)"	[Ref.11738090]HC50=70 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11738090	Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.	"Ali MF, Soto A, Knoop FC, Conlon JM."	"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)."
DRAMP02136	GLLGPLLKIAAKVGSNLL	18	"Antimicrobial peptide 7 (XT-7; Frogs, amphibians, animals)"	P84381	Not found	Not found	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Has very strong antibacterial activity against many Gram-negative bacteria and the Gram-positive bacteria S.pneumoniae and Enterococcus sp. There is moderate antimicrobial activity against the Gram-negative bacterium P.aeruginosa and yeast C. albicans and weaker activity against the Streptococcal strains and E.coli. Has hemolytic activity against human red blood cells (HC50=70 ?M). Seems to disrupt the membranes by adopting an alpha-helical conformation.
Tissue specificity: Expressed by the skin glands.
PTM: Amidation on Leu-18 is required to adopt an alpha-helical conformation in a hydrophobic solvent. The absence of amidation leads to a decrease in cationicity leading to a more than a 10-fold decrease in antimicrobial activities."	"Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=5 ?M);##yeast Candida albicans (MIC=40 ?M).##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 ?M), Staphylococcus aureus (MRSA) (MIC=7 ?M), Staphylococcus epidermidis 1420129 (MIC=3 ?M), S. saprophyticus 1950556 (MIC=13 ?M), Escherichia coli 25922 (MIC=6 ?M), Streptococcus group C 1541035 (MIC=3 ?M), Shigella sonnei 1840187 (MIC=35 ?M), Pseudomonas aeruginosa 0380972 (MIC=60 ?M), Enterobacter cloacae 1441323 (MIC=35 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11738090	Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.	"Ali MF, Soto A, Knoop FC, Conlon JM."	"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)."
DRAMP02219	GILSSFKGVAKGVAKNLAGKLLDELKCKITGC	32	"Ranatuerin-2AUa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana aurora aurora (Northern red-legged frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Activity against a range of Gram-positive and Gram-negative bacteria (minimum inhibitory concentrations<20 ?M) but low hemolytic activity against human erythrocytes. 	"[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=5 ?M), Pseudomonas aeruginosa (MIC=5 ?M), Enterobacter cloacae (MIC=5 ?M), Klebsiella pneumoniae (MIC=10 ?M), P. mirabilis (MIC>40 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=20 ?M), Staphylococcus epidermidis (MIC=20 ?M), Enterococcus faecalis (MIC>40 ?M), Streptococcus Group B (MIC=20 ?M);##Yeast: Candida albicans (MIC>40 ?M)"	[Ref.15325526]HC50=290 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15325526	Dev Comp Immunol. 2005;29(1):83-90.	"Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T."	Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora.
DRAMP02220	GIMDTVKNVAKNLAGQLLDKLKCKITAC	28	"Ranatuerin-2PLa (Frogs, amphibians, animals)"	A7WNV6	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (North America pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: May have antimicrobial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 23-28."	Gram-negative bacterium: Escherichia coli (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP02221	GIMDTVKNAAKDLAGQLLDKLKCRITGC	28	"Ranatuerin-2PLb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (North America pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: May have antimicrobial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli (MIC=3 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP02222	GLLDTIKNTAKNLAVGLLDKIKCKMTGC	28	"Ranatuerin-2PLc (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (North America pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: May have antimicrobial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli (MIC=3 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP02223	GIMDSVKNVAKNIAGQLLDKLKCKITGC	28	"Ranatuerin-2PLd (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (North America pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: May have antimicrobial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli (MIC=16 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP02224	GIMDSVKNAAKNLAGQLLDTIKCKITAC	28	"Ranatuerin-2PLe (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (North America pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: May have antimicrobial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP02225	GIMDTVKNAAKDLAGQLDKLKCRITGC	27	"Ranatuerin-2PLf (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana palustris (North America pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: May have antimicrobial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli (MIC=23 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP18494	FIHHIIGGLFSAGKAIHRLIRRRRR	25	TP4	L0CKG3	Piscidin	TP4	Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)	"Antibacterial, Antifungal, anticancer, wound healing, Anti-Gram+, Anti-Gram-, Antimicrobial"	Protein level	Alpha helix	"1.0x sarkosyl can drive TP4 into a conformational change from a non-structure to an alpha-helical structure, and that LPS can also drive TP4 to an alpha-helical structure but with high hydrophobicity and low solubility."	5H2S	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. Has hemolytic activity.	"[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=8 ¦Ìg/ml; MBC=16 ¦Ìg/ml), Methicillin-resistant Staphylococcus aureus (MIC=16 ¦Ìg/ml; MBC=32 ¦Ìg/ml);##Gram-negative bacterium: Pseudomonas aeruginosa (MIC=64 ¦Ìg/ml; MBC=128 ¦Ìg/ml);##Fungi: Candida albicans (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml)"	"[Ref.29040295] 2% hemolysis at 0.78 ¦Ìg/ml, 5% hemolysis at 1.56 ¦Ìg/ml, 45% hemolysis at 3.13 ¦Ìg/ml, 85% hemolysis at 6.25 ¦Ìg/ml, 98% hemolysis at 12.50 ¦Ìg/ml, 100% hemolysis at 25.00 ¦Ìg/ml against mouse red blood cell"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	"bacterial outer membrane target protein, OprI-binding"	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP03002	GIGAVLKVLTTGLPALISWIKRKRQQ	26	"Melittin (Allergen Api m 3; Allergen Api m III; Insects, animals)"	"P01501,P01503"	Belongs to the melittin family	MELT	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	"2MLT, 3QRX, 1BH1"	"Function: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. It increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. It acts synergistically with phospholipase A2. "	"[Ref.29783753] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=2 ¦ÌM), Listeria monocytogenes CMCC 54004 (MIC=1 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ¦ÌM), Escherichia coli UB 1005 (MIC=2 ¦ÌM), Salmonella pullorum C7913 (MIC=8 ¦ÌM), Salmonella enterica subsp enterica CMCC 50071 (MIC=2 ¦ÌM)"	[Ref.29859288] MHC=1 ¦ÌM against human red blood cell.##[Ref.2978375] 46.80% hemolysis at 2¦ÌM against human red blood cell##[Ref.20472009] Wild-type melittin:AVG ¡À S.D.(%)=0.077¡À0.002 (35) against human red blood cell.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (forms a transmembrane alpha-helix in the cell membrane.)	29859288##29783753##6309516##20472009##20403370##5300771	Gene. 2018 May 30. pii: S0378-1119(18)30617-6.##Molecules. 2018 May 19;23(5). pii: E1220. ##Eur J Biochem. 1983 Sep 1;135(1):123-126.##Peptides. 2010 Aug;31(8):1473-1479.##Toxicon. 2010 Sep 1;56(3):355-362.##Res Dev Tech Rep. 1967 Dec 5:1-13.	"Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S.##Hou J, Liu Z, Cao S, Wang H, Jiang C, Hussain MA, Pang S.##Vlasak R, Unger-Ullmann C, Kreil G, Frischauf AM.##Sciani JM, Marques-Porto R, Louren?o Junior A, Orsi Rde O, Ferreira Junior RS, Barraviera B, Pimenta DC.##Ferreira Junior RS, Sciani JM, Marques-Porto R, Junior AL, Orsi Rde O, Barraviera B, Pimenta DC.##Fennell JF, Shipman WH, Cole LJ."	Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro.##Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine AlphaS1-Casein.##Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin.##Identification of a novel melittin isoform from Africanized Apis mellifera venom.##Africanized honey bee (Apis mellifera) venom profiling: Seasonal variation of
DRAMP02237	GLMDTIKGVAKTVAASWLDKLKCKITGC	28	"Ranatuerin-2Ya (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Not found	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Ranatuerin-2Ya showed appreciably greater cytolytic activity against HepG2 cells (LC(50)=20microM) than against erythrocytes (LC(50)>100microM).	[Ref.19254736] Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M).	[Ref.19254736] LC50>100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19254736	Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.	"Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis."
DRAMP02238	GLADYWRTAFRANFANLGPGIRCKSARC	28	"Ranatuerin-2ZHa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana zhenhaiensis (Chinese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=6 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>32 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22943778	Zoolog Sci. 2012 Sep;29(9):553-558.	"Xu B, Che H, Kang L, Zheng S, Mu S, Wan F."	"Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis."
DRAMP02239	SMISVLKNLGKVGLGFVACKVNKQC	25	"Ranatuerin-1Ga (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana grylio (North American pig frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=3.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M).##Yeast: Candida albicans (MIC=110 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10828493	Regul Pept. 2000 Jun 30;90(1-3):53-60.	"Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM."	Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio.
DRAMP02241	GLLLDTLKGAAKDIAGIALEKLKCKITGCKP	31	"Ranatuerin-2G (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana grylio (North American pig frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=19 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=150 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10828493	Regul Pept. 2000 Jun 30;90(1-3):53-60.	"Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM."	Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio.
DRAMP01390	TSRCYIGYRRKVVCS	15	"Odorranain-T1 (OdT1; Frogs, amphibians, animals)"	A6MBS1	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Odorranain-T1 adopts 28.2% turn structure in water solution.	None	Function: Odorranain-T1 exhibites moderate antimicrobial activities against all of the tested microbes.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=17.50 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=35.00 ¦Ìg/ml), Bacillus subtilis (MIC=17.50 ¦Ìg/ml).##Yeast: Candida albicans (MIC=8.75 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01389	FLPPSPWKETFRTS	14	"Odorranain-S1 (OdS1; Frogs, amphibians, animals)"	"A6MBS0, A6MBR9"	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Odorranain-S1 exhibites moderate antimicrobial activities against all of the tested microbes.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=42.50 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=21.25 ¦Ìg/ml), Bacillus subtilis (MIC=85.00 ¦Ìg/ml).##Yeast: Candida albicans (MIC=21.25 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP02251	GILSSFKGVAKGVAKDLAGKLLETLKCKITGC	32	"Ranatuerin-2CSa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana cascadae (Cascades frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Alpha helix (4 helices; 25 residues)	"In a 2,2,2-trifluoroethanol (TFE-d(3))-H(2)O solvent mixture, the structure is characterised by a full length helix-turn-helix conformation between residues I(2)-L(21), L(22)-L(25) and K(26)-T(30), respectively."	2K10 resolved by NMR.	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has Hemolytic activity against human erythrocytes. 	[Ref.17451843]Gram-negative bacterium:Escherichia coli ATCC 25726 (MIC=5 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10 ?M)	[Ref.17451843] LD50=150 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys27 and Cys32)	Disulfide bond between Cys27 and Cys32.	L	No cytotoxicity information found	Not found	17451843##18387372	Peptides. 2007 Jun;28(6):1268-1274.##Biochim Biophys Acta. 2008 Jun;1784(6):924-929.	"Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C.##Subasinghage AP, Conlon JM, Hewage CM."	"Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.##Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: identification of a full length helix-turn-helix motif."
DRAMP02252	GLLDAIKDTAQNLFANVLDKIKCKFTKC	28	"Ranatuerin 2SKa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sakuraii (Japanese brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M).##Yeast: Candida albicans (MIC>50 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys23 and Cys28)	Disulfide bond between Cys23 and Cys28.	L	No cytotoxicity information found	Not found	17174009	Peptides. 2007 Mar;28(3):505-514.	"Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM."	Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.
DRAMP01108	GIGTKILGGVKTALKGALKELASTYVN	27	"Maximin-2 (Toads, amphibians, animals)"	"P83081, P83086, Q58T49"	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins.	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. 
Tissue specificity: Expressed by the skin glands."	"[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml)."	[Ref:11835991]Little hemolytic activity at 50 ¦Ìg/ml against red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP03998	RKKWFW	6	PAF26 (Trp-rich; combinatorial library)	No entry found 	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Synthetic	Rich	"In general, positively charged residues (arginine or lysine) and residues with aromatic rings (tryptophan or phenylalanine) rendered antifungal activity."	None	"Function: Antibacterial against Gram-negative bacterium. The antifungal mixture is also antibacterial, with a predominance of basic and aromatic residues."	"[Ref.11976121] Gram-negative bacterium: Escherichia coli DH5¦Á (MIC=160 ?M, IC50>80 ?M);##Fungi: Penicillium digitatum PHI-26 (MIC=20 ?M, IC50=11 ¡À 1 ?M), Penicillium italicum PHI-1 (MIC=40 ?M,  IC50=22 ¡À 3 ?M), Botrytis cinerea CECT2100 (MIC=60 ?M, IC50=38 ¡À 24 ?M), Fusarium oxysporum CECT2866 (MIC=80 ?M, IC50=45 ¡À 4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11976121	Appl Environ Microbiol. 2002 May;68(5):2453-60.	"L¨®pez-Garc¨ªa B, P¨¦rez-Pay¨¢ E, Marcos JF."	Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.
DRAMP01107	GIGTKILGGVKTALKGALKELASTYAN	27	"Maximin-1 (Toads, amphibians, animals)"	"P83080, Q58T87"	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer"	Protein level	Not found	Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins.	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity.
Toxic dose: LD50 is 8.2 mg/kg by intraperitoneal injection into mice.
Tissue specificity: Expressed by the skin glands."	"[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml);##Virus: HIV-1 (IC50=15.5 ?g/ml, EC50=21.4 ?g/ml);##Cancer cell lines: C8166 (IC50=15.3 ?g/ml), Molt-4 (IC50=24.3 ?g/ml), BIU-87 (IC50=20.5 ?g/ml), T24 (IC50=35.4 ?g/ml)."	[Ref:11835991]Little hemolytic activity at 50 ¦Ìg/ml against red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP02268	GWASKIGQTLGKIAKVGLKELIQPK	25	"Xenopsin precursor fragment (XPF; Frogs, amphibians, animals)"	P07198	Belongs to the magainin family	Not found	Xenopus laevis (African clawed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: XPF has antimicrobial activity.
Tissue specificity: XPF is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa, it is stored as active, processed peptides in large granules within the granular gland secretions of the skin."	"Gram-negative bacteria: Escherichia coli (MIC=16-31 ?g/ml), K. Pneumonae (MIC=62-125 ?g/ml), Pseudomonas aeruginosa (MIC=125-250 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 ?g/ml), Streptococcus faecalis (MIC=250-500 ?g/ml).##Yeast: Candida albicans (MIC=250-500 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1717472	J Biol Chem. 1991 Oct 15;266(29):19851-19857.	"Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M."	Antimicrobial peptides in the stomach of Xenopus laevis.
DRAMP02269	GVLSNVIGYLKKLGTGALNAVLKQ	24	"Antimicrobial peptide PGQ (PGQ; Frogs, amphibians, animals)"	P39080	Belongs to the magainin family	pgq	Xenopus laevis (African clawed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix(potential)	Not found	None	"Function: Antimicrobial peptide.
Tissue specificity: Is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin."	"Gram-negative bacteria: Escherichia coli (MIC=62-250 ?g/ml), K. Pneumonae (MIC=125-250 ?g/ml), Pseudomonas aeruginosa (MIC=250-500 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 ?g/ml), Streptococcus faecalis (MIC=250-500 ?g/ml).##Yeast: Candida albicans (MIC=250-500 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1717472	J Biol Chem. 1991 Oct 15;266(29):19851-19857.	"Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M."	Antimicrobial peptides in the stomach of Xenopus laevis.
DRAMP02271	GIGKFLHSAKKFGKAFVGEIMNS	23	"Magainin-2 (Magainin II; chain of Magainins; Frogs, amphibians, animals)"	C0HKN6	Belongs to the gastrin/cholecystokinin family. Magainin subfamily.	N/A	Xenopus ruwenzoriensis (Uganda clawed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal"	Protein level	Alpha helix	"The secondary structure is shown to be helical in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution."	"2MAG, 2LSA resolved by NMR."	"Function: Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents.
Tissue specificity: Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin."	"Gram-negative bacteria: Escherichia coli D31 (MIC=5 ?g/ml), Klebsiella pneumoniae (MIC=10 ?g/ml), Escherichia coli (MIC=50 ?g/ml), Pseudomonas putida (MIC=10 ?g/ml), Citrobacter freundii (MIC=30 ?g/ml), Enterobacter cloacae (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Serratia marcescens (MIC=100 ?g/ml), Proteus mirabilis (MIC>100 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis (MIC=10 ?g/ml), Staphylococcus aureus (MIC=50 ?g/ml), Streptococcus fecalis (MIC>100 ?g/ml).##Protozoa: Paramecium caudatum (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	3299384##9090128##PubMed ID is not available	Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-5453.##J Biomol NMR. 1997 Feb;9(2):127-135.##To be Published.	"Zasloff M.##Gesell J, Zasloff M, Opella SJ.##Vermeer LS, Kozlowska J, Lorenz CD, Mason JA."	"Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.##Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution.##All Atom Simulations of the Initial Binding of Magainin and Pleurocidin to Membranes Comprising a Mixture of Anionic and Zwitterionic"
DRAMP02272	GMASKAGAIAGKIAKVALKAL	21	"PGLa (chain of PYLa/PGLa A; Frogs, amphibians, animals)"	"Q99134, B7ZSG6, Q91826"	Belongs to the gastrin/cholecystokinin family (Magainin subfamily)	pgla-a AND pgla-b	Xenopus laevis (African clawed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: PGLa display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa also displays antifungal activity against C. albicans ATCC 14053.
Tissue specificity: Expressed by the skin glands. Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. Stored as active, processed peptides in large granules within the granular gland secretions of the skin.
PTM: Leucine amide at position 21."	"Gram-negative bacteria: Escherichia coli 25922 (MIC=62-125 ?g/ml), Klebsiella pneumoniae 13883 (MIC=250-500 ?g/ml), Pseudomonas aeruginosa 27853 (MIC=250-500 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=125-500 ?g/ml), Strepococcus faecalis (MIC>500 ?g/ml).##Yeast: Candida albicans 14053 (MIC=250-500 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	3606567##1717472	Biochem J. 1987 Apr 1;243(1):113-120.##J Biol Chem. 1991 Oct 15;266(29):19851-19857.	"Giovannini MG, Poulter L, Gibson BW, Williams DH.##Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M."	Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones.##Antimicrobial peptides in the stomach of Xenopus laevis.
DRAMP02273	KIAKVALKAL	10	"PGLa-H (chain of PYLa/PGLa A; Frogs, amphibians, animals)"	"Q99134, B7ZSG6, Q91826"	Belongs to the gastrin/cholecystokinin family (Magainin subfamily)	pgla-a AND pgla-b	Xenopus laevis (African clawed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: PGLa-H display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa-H shows moderate antibacterial activity against the multidrug-resistant methicillin-resistant S. aureus (MRSA) but exhibits hemolytic activity.
Tissue specificity: Expressed by the skin glands. Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. Stored as active, processed peptides in large granules within the granular gland secretions of the skin.
PTM: Leucine amide at position 10."	"[Ref.22014884]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.7 ?g/ml), Bacillus subtilis (MIC=14.4 ?g/ml), Staphylococcus aureus (MRSA) (MIC=67.8 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.6 ?g/ml)"	"[Ref.22014884]3.15% hemolytic activity at 100 ¦Ìg/mL, 7.95% hemolytic activity at 200 ¦Ìg/mL against rabbit red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22014884##1717472	Int J Antimicrob Agents. 2011 Dec;38(6):510-515.##J Biol Chem. 1991 Oct 15;266(29):19851-19857.	"Hou F, Li J, Pan P, Xu J, Liu L, Liu W, Song B, Li N, Wan J, Gao H.##Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M."	Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis.##Antimicrobial peptides in the stomach of Xenopus laevis.
DRAMP02274	SAPRGCWTKSYPPKPCK	17	"Ranacyclin-E (Frogs, amphibians, animals)"	P83663	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Has hemolytic activity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores.
Tissue specificity: Expressed by the skin granular glands."	"[Ref.14636071]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3 ?M), Staphylococcus lentus (MIC=7 ?M), Micrococcus luteus (MIC=5 ?M);##Gram-negative bacteria: Yersinia pseudotuberculosis YP III (MIC=9 ?M), Pseudomonas syringae pv tabaci (MIC=80 ?M);##Fungi: Candida tropicalis (MIC=7.4 ?M), C. guillermondii (MIC=3.4 ?M), Phytophthora nicotianae spores (MIC=32 ?M)."	[Ref.14636071] It has 55% hemolytic activity at 100 ¦ÌM against human erythrocytes	Cyclic	Free	Amidation	Disulfide bond between Cys6 and Cys16.	L	No cytotoxicity information found	Cell membrane	14636071	Biochemistry. 2003 Dec 2;42(47):14023-14035.	"Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M."	"Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity."
DRAMP02275	GALRGCWTKSYPPKPCK	17	"Ranacyclin-T (Frogs, amphibians, animals)"	P83719	Belongs to the frog skin active peptide family (Brevinin subfamily)	RNCT	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	MOA: The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Has hemolytic activity.	"[Ref.14636071]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3 ?M), Staphylococcus lentus (MIC=10 ?M), Micrococcus luteus (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=30 ?M), Yersinia pseudotuberculosis YP III (MIC=5 ?M), Pseudomonas syringae pv tabaci (MIC=16 ?M);##Fungi: Candida albicans ATCC 10231 (MIC=22 ?M), Candida tropicalis (MIC=14 ?M), C. guillermondii (MIC=1 ?M), Phytophthora nicotianae spores (MIC=16 ?M)."	[Ref.14636071] It has 20% hemolytic activity at 100 ¦ÌM against human erythrocytes	Cyclic	Free	Amidation	Disulfide bond between Cys6 and Cys16.	L	No cytotoxicity information found	Cell membrane	14636071	Biochemistry. 2003 Dec 2;42(47):14023-14035.	"Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M."	"Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity."
DRAMP02278	AALRGCWTKSIPPKPCPGKR	20	"Ranacyclin-B-RL1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana livida (Ranidae frogs)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus (MIC=5.8 ?M), Bacillus subtilis (MIC=46.2 ?M);##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys6 and Cys16.	L	No cytotoxicity information found	Not found	21927839	Amino Acids. 2012 Jul;43(1):309-316.	"Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R."	Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins.
DRAMP02288	FIGPVLKIAAGILPTAICKIFKKC	24	"Gaegurin-RN1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana nigrovittata 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has hemolytic activity against rabbit red cells..	"[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=2.34 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=4.69 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=18.75 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 ?g/ml)"	[Ref.19778602] It has 46.13 ¡À 1.49% hemolytic activity at 100 ¦Ìg/ml against rabbit red blood cells	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71.	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP02290	FLGPIIKIATGILPTAICKFLKKC	24	"Gaegurin-RN5 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana nigrovittata 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Has hemolytic activity against rabbit red cells.	"[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=3.75 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=62.50 ?g/ml), Bacillus subtilis (MIC=4.69 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 ?g/ml)."	[Ref.19778602] It has no detectable hemolysis at the concentration up to 100 ¦Ìg/ml	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	19778602	Genomics. 2010 Jan;95(1):66-71.	"Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R."	"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata."
DRAMP02291	SLFSLIKAGAKFLGKNLLKQGACYAACKASKQC	33	"Gaegurin-1 (Gaegurin 1; GGN1; Frogs, amphibians, animals)"	P80395	Belongs to the frog skin active peptide family (Brevinin subfamily)	GGN1	Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has hemolytic activity against rabbit red cells.	"[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=5 ?g/ml), Staphylococcus epidermidis (MIC=50 ?g/ml), Bacillus subtilis (MIC=50 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=100 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=25 ?g/ml)."	"[Ref.7999137] It has 0.04% hemolytic activity at 0.1 ¦Ìg/ml, 0.14% hemolytic activity at 1 ¦Ìg/ml, 0.51% hemolytic activity at 10 ¦Ìg/ml, 0.59% hemolytic activity at 100 ¦Ìg/ml against human red blood cells."	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	7999137	Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.	"Park JM, Jung J-E, Lee BJ.1994"	"Antimicrobial peptides from the skin of a Korean frog, Rana rugosa."
DRAMP02292	GIMSIVKDVAKNAAKEAAKGALSTLSCKLAKTC	33	"Gaegurin-2 (Gaegurin 2; GGN2; Frogs, amphibians, animals)"	P80396	Belongs to the frog skin active peptide family (Brevinin subfamily)	GGN2	Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=75 ?g/ml).##Fungi: Saccharomyces cerevisiae (MIC=150 ?g/ml), Candida albicans (MIC=150 ?g/ml), Salmonella typhimurium (MIC=150 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)."	"[Ref.7999137] It has 0.19% hemolytic activity at 0.1 ¦Ìg/ml, 0.16% hemolytic activity at 1 ¦Ìg/ml, 0.31% hemolytic activity at 10 ¦Ìg/ml, 0.82% hemolytic activity at 100 ¦Ìg/ml against human red blood cells."	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	7999137	Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.	"Park JM, Jung JE, Lee BJ."	"Antimicrobial peptides from the skin of a Korean frog, Rana rugosa."
DRAMP02293	GIMSIVKDVAKTAAKEAAKGALSTLSCKLAKTC	33	"Gaegurin-3 (Gaegurin 3; GGN3; Frogs, amphibians, animals)"	P80397	Belongs to the frog skin active peptide family (Brevinin subfamily)	GGN3	Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=75 ?g/ml).##Fungi: Saccharomyces cerevisiae (MIC>200 ?g/ml), Candida albicans (MIC>200 ?g/ml), Salmonella typhimurium (MIC=150 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)."	"[Ref.7999137] It has 0.11% hemolytic activity at 0.1 ¦Ìg/ml, 0.12% hemolytic activity at 1 ¦Ìg/ml, 0.35% hemolytic activity at 10 ¦Ìg/ml, 1.20% hemolytic activity at 100 ¦Ìg/ml against human red blood cells."	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	7999137	Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.	"Park JM, Jung JE, Lee BJ."	"Antimicrobial peptides from the skin of a Korean frog, Rana rugosa."
DRAMP02294	GILDTLKQFAKGVGKDLVKGAAQGVLSTVSCKLAKTC	37	"Gaegurin-4 (Gaegurin 4; GGN4; Frogs, amphibians, animals)"	"P80398, Q91328, Q98TA6"	Belongs to the frog skin active peptide family (Brevinin subfamily)	GGN4	Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal"	Protein level	Alpha helix (3 helices; 22 residues)	"In 100% H2O, Gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34 (Ref.2)."	2G9L resolved by NMR.	"Function: Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. Has hemolytic activity against rabbit red cells.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 31-37."	"[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=100 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=75 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=200 ?g/ml), Candida albicans (MIC=200 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)."	"[Ref.7999137] It has 0.50% hemolytic activity at 0.1 ¦Ìg/ml, 0.74% hemolytic activity at 1 ¦Ìg/ml, 0.78% hemolytic activity at 10 ¦Ìg/ml, 1.67% hemolytic activity at 100 ¦Ìg/ml against human red blood cells"	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	7999137##17141187##11004488	Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.##Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-597.##Biochim Biophys Acta. 2000 Jun 21;1492(1):185-190.	"Park JM, Jung JE, Lee BJ.##Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH.##Kwon SY, Carlson BA, Park JM, Lee BJ."	"Antimicrobial peptides from the skin of a Korean frog, Rana rugosa.##Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.##Structural organization and expression of the gaegurin 4 gene of Rana rugosa."
DRAMP02295	FLGALFKVASKVLPSVFCAITKKC	24	"Gaegurin-5 (Gaegurin 5; GGN5; Brevinin-1EMa; Frogs, amphibians, animals)"	"P80399, Q91329"	Belongs to the frog skin active peptide family (Brevinin subfamily)	GGN5	Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal"	Protein level	Not found	Not found	None	"Function: Has low hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. PTM: Problely contains one disulfide bond 18-24."	"[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=50 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=50 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=50 ?g/ml), Candida albicans (MIC=50 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml)."	"[Ref.7999137] It has 0.19% hemolytic activity at 0.1 ¦Ìg/ml, 0.31% hemolytic activity at 1 ¦Ìg/ml, 0.78% hemolytic activity at 10 ¦Ìg/ml, 1.01% hemolytic activity at 100 ¦Ìg/ml against human red blood cells"	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	7999137	Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.	"Park JM, Jung JE, Lee BJ."	"Antimicrobial peptides from the skin of a Korean frog, Rana rugosa."
DRAMP02296	FLPLLAGLAANFLPTIICKISYKC	24	"Gaegurin-6 (Gaegurin 6; GGN6; Frogs, amphibians, animals)"	P80400	Belongs to the frog skin active peptide family (Brevinin subfamily)	GGN6	Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has low hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. PTM: Problely contains one disulfide bond 18-24."	"[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=50 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=50 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=50 ?g/ml), Candida albicans (MIC=50 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)."	"[Ref.7999137] It has 0.39% hemolytic activity at 0.1 ¦Ìg/ml, 0.62% hemolytic activity at 1 ¦Ìg/ml, 0.78% hemolytic activity at 10 ¦Ìg/ml, 0.86% hemolytic activity at 100 ¦Ìg/ml against human red blood cells"	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	7999137	Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.	"Park JM, Jung JE, Lee BJ."	"Antimicrobial peptides from the skin of a Korean frog, Rana rugosa."
DRAMP02314	RCRFCCRCCPRMRGCGICCRF	21	"Hepcidin (fish, chordates, animals)"	A1Z0M0	Belongs to the hepcidin family	hamp	Larimichthys crocea (Croceine croaker) (Pseudosciaena crocea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages.
Tissue specificity: Expressed in all tissues tested, with highest levels of expression in kidney and lowest levels in liver. Intra-peritoneal injection of lipopolysaccharide results in increased expression in heart, spleen and stomach, but not in kidney or liver.
PTM: Contains four disulfide bonds 2-19; 5-8; 6-15; 9-18."	"Gram-negative bacteria: Vibrio alginolyticus(MIC=24 ?M), V. fluvialis, V. harveyis (MIC=12 ?M) and Vibrio parahaemolyticus (MIC=6 ?M), Aeromonas hydrophila (MIC=6 ?M), Escherichia coli (MIC=24 ?M), Escherichia coli BL21(DE3)plysS (MIC=6 ?M);##Gram-positive bacteria: Bacillus cereus (MIC=24 ?M), Bacillus subtilis (MIC=6 ?M), C. glutamicum (MIC=3 ?M), Micrococcus luteus (MIC=3 ?M), M. lysodeikticus, Staphylococcus aureus (MIC=6 ?M) and S.epidermis (MIC=12 ?M).##Fungi: Aspergillus niger (MIC=24 ?M), F;##Graminearum (MIC=24 ?M) and Fusarium solani (MIC=24 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys2 and Cys19; Cys5 and Cys8; Cys6 and Cys15,Cys9 and Cys18."	L	No cytotoxicity information found	Not found	19150638##19344770	Peptides. 2009 Apr;30(4):638-646.##Fish Shellfish Immunol. 2009 Jun;26(6):864-870.	"Wang KJ, Cai JJ, Cai L, Qu HD, Yang M, Zhang M.##Zhang J, Yan Q, Ji R, Zou W, Guo G."	"Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide.##Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea."
DRAMP02315	FFGWLIKGAIHAGKAIHGLIHRRRH	25	"Chrysophsin-1 (fish, chordates, animals)"	P83545	Belongs to the pleurocidin family	Not found	Chrysophrys major (Red sea bream) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	Function: Shows hemolytic activity human red blood cells.	"[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=10 ?M), S.iniae F-8502 (MIC=2.5 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=2.5 ?M), Vibriopenaeicida KHA (MIC=10 ?M), V. harveyi ATCC 14126 (MIC=2.5 ?M), V. vulnificus ATCC 33148 (MIC=5 ?M), Aeromonas salmonicida NCMB 1102 (MIC=10 ?M), Pseudomonas putida ATCC 12633 (MIC=40 ?M)."	"[Ref.12581207]10% hemolytic activity at 0.25 ¦ÌM, 80% hemolytic activity at 1 ¦ÌM against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	12581207	Eur J Biochem. 2003 Feb;270(4):675-686.	"Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T."	"Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major."
DRAMP02316	FFGWLIRGAIHAGKAIHGLIHRRRH	25	"Chrysophsin-2 (fish, chordates, animals)"	P83546	Belongs to the pleurocidin family	Not found	Chrysophrys major (Red sea bream) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	Function: Shows hemolytic activity human red blood cells.	"[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=5 ?M), S.iniae F-8502 (MIC=1.5 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=1.25 ?M), Vibriopenaeicida KHA (MIC=5 ?M), V. harveyi ATCC 14126 (MIC=5 ?M), V. vulnificus ATCC 33148 (MIC=2.5 ?M)."	"[Ref.12581207]10% hemolytic activity at 0.25 ¦ÌM, 70% hemolytic activity at 1 ¦ÌM against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	12581207	Eur J Biochem. 2003 Feb;270(4):675-686.	"Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T."	"Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major."
DRAMP02317	FIGLLISAGKAIHDLIRRRH	20	"Chrysophsin-3 (fish, chordates, animals)"	P83547	Belongs to the pleurocidin family	Not found	Chrysophrys major (Red sea bream) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	Function: Shows hemolytic activity human red blood cells.	"[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=10 ?M), S.iniae F-8502 (MIC=10 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=10 ?M), Vibriopenaeicida KHA (MIC=10 ?M), V. harveyi ATCC 14126 (MIC=5 ?M), V. vulnificus ATCC 33148 (MIC=10 ?M), Aeromonas salmonicida NCMB 1102 (MIC=10 ?M), Pseudomonas putida ATCC 12633 (MIC=40 ?M)."	"[Ref.12581207]0% hemolytic activity at 0.25 ¦ÌM, 10% hemolytic activity at 1 ¦ÌM against human erythrocytes."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	12581207	Eur J Biochem. 2003 Feb;270(4):675-686.	"Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T."	"Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major."
DRAMP02318	FIGGIISFFKRLF	13	"Grammistin Pp1 (Group II grammistin; fish, chordates, animals)"	P69842	Belongs to the grammistin family (Group 2 subfamily)	Not found	Pogonoperca punctata (Clown grouper) (Bearded grouper)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=3.13 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=3.13 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC>50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Fish. Sci. 2001 Oct;67:928-933.	"Yokota H, Nagashima Y, Shiomi K."	Interaction of grammistins with lipids and their antibacterial activity.
DRAMP02320	FIGGIISFIKKLF	13	"Grammistin PpIIb (Group II grammistin; fish, chordates, animals)"	P69844	Belongs to the grammistin family (Group 2 subfamily)	Not found	Pogonoperca punctata (Clown grouper) (Bearded grouper)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has antibacterial activities.	"[Ref.Fish. Sci. 2001 Feb;67:163-169.]Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=3.13 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC>50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=12.5 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Phospholipids	PubMed ID is not available	Fish. Sci. 2001 Feb;67:163-169.	"Shiomi K, Yokota H, Nagashima Y, Ishida M."	"Primary and secondary structures of grammistins, peptide toxins isolated from the skin secretion of the soapfish Pogonoperca punctata."
DRAMP02321	NWRKILGQIASVGAGLLGSLLAGYE	25	"Grammistin Pp3 (Group III grammistin; fish, chordates, animals)"	P69847	Belongs to the grammistin family (Group 3 subfamily)	Not found	Pogonoperca punctata (Clown grouper) (Bearded grouper)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function:  Has hemolytic activity. Thanks to its abundant amphiphilic alpha-helices, it may integrate into membrane phospholipids, leading to lysis of the membrane."	"[Ref.Fish. Sci. 2001 Oct;67:928-933.]Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=50 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=50 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC>50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=12.5 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=50 ?g/ml)."	[Ref.Fish. Sci. 2001 Oct;67:928-933.]75 HU/mg hemolytic activity against horse erythrocytes(1 HU was defined as the amount of peptide causing 50% hemolysis)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Fish. Sci. 2001 Oct;67:928-933.	"Yokota H, Nagashima Y, Shiomi K."	Interaction of grammistins with lipids and their antibacterial activity.
DRAMP02324	AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS	30	"SAMP H1 (fish, chordates, animals)"	"P84408, Q5GMQ6"	Belongs to the histone H1/H5 family	Not found	Salmo salar (Atlantic salmon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=2 ?M), Aeromonas salmonicida subsp salmonicida (MIC=4 ?M), Vibrio anguillarum (MIC=1 ?M) Salmonella typhimurium (MIC=4 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=2 ?M), Listeria ivanovii (MIC=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15917539	Antimicrob Agents Chemother. 2005 Jun;49(6):2399-2406.	"Luders T, Birkemo G.A, Nissen-Meyer J, Andersen O, Nes I.F."	Proline conformation-dependent antimicrobial activity of a proline-rich histone H1 N-terminal peptide fragment isolated from the skin mucus of Atlantic salmon.
DRAMP02330	FFHHIFRGIVHVGKTIHRLVTG	22	"Piscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)"	Q8UUG0	Belongs to the pleurocidin family	Not found	Morone saxatilis (Striped bass)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	"2JOS, 2OJM resolved by NMR."	Function: Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria. Also has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores.	"[Ref.11713517]Gram-positive bacteria: Enterococcus faecalis VRE (MIC=5-10 ?M), E. faecalis (MIC=2.5-5 ?M), Listeria monocytogenes (MIC=2.5-5 ?M), Micrococcus luteus (MIC=10-20 ?M), Staphylococcus aureus MRSA (MIC=1.25-2.5 ?M), S. epidermitis (MIC=5-10 ?M), S. saprophiticus (MIC=5-10 ?M), Staphylococcus xylosus (MIC>20 ?M), S. agalactiae (MIC=1.25-2.5 ?M), S. bovis (MIC=1.25-2.5 ?M), S. equisimilis (MIC=2.5-5 ?M), S. mitis (MIC=1.25-2.5 ?M), S. Pneumonae (MIC=1.25-2.5 ?M), S. pyrogenes (MIC=1.25-2.5 ?M), Streptococcus iniae KST740 ak (MIC=1.25-2.5 ?M), S. iniae KSTSi 6P (MIC=1.25-2.5 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 ?M), Burkholderia cepacia (MIC>20 ?M), Vibrio Cholera (MIC=2.5-5 ?M), Escherichia coli (MIC=5-10 ?M), Enterobacter cloacae (MIC=10-20 ?M), E. Aerogenes (MIC=10-20 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), K. oxytoca (MIC=5-10 ?M), Salmonella choleraesuis (MIC=10-20 ?M), S. typhimurium (MIC=10-20 ?M), S. arizonae (MIC=10-20 ?M), Serratia marcescens (MIC>20 ?M), Shigella flexneri (MIC=2.5-5 ?M), S. sonnei (MIC=5-10 ?M), Yersinia enterocolitica (MIC=2.5-5 ?M); Fungi: Neurospora crassa (MIC=1.56-3.12 ?M), A. fumigatus (MIC=50-100 ?M), F. axysporum (MIC=0.78-1.56 ?M), F. culmorum (MIC=0.39-0.78 ?M), C. ablicans (MIC=10-20 ?M), C. glabrata (MIC=10-20 ?M), C. lusitania (MIC=10-20 ?M), C. tropacalis (MIC=10-20 ?M)."	"[Ref.11713517]10% hemolytic activity at 5 ¦Ìg/mL, 60% hemolytic activity at 10 ¦Ìg/mL, 100% hemolytic activity at 50 ¦Ìg/mL against human erythrocytes "	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11713517	Nature. 2001 Nov 15;414(6861):268-269.	"Silphaduang U, Noga EJ."	Peptide antibiotics in mast cells of fish.
DRAMP02331	FFHHIFRGIVHVGKTIHKLVTG	22	"Piscidin-2 (Pis-2; fish, chordates, animals)"	Q8UUG2	Belongs to the pleurocidin family	Not found	Morone chrysops (White bass)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Seems to disrupt the membranes by adopting an alpha helical conformation.
Tissue specificity: Expressed in gill, skin, intestine, spleen, anterior kidney, and blood cells."	"Gram-positive bacteria: Enterococcus faecalis (MIC=5-10 ?M), E. faecalis (MIC=2.5-5 ?M), Listeria monocytogenes (MIC=2.5-5 ?M), Micrococcus luteus (MIC=10-20 ?M), Staphylococcus aureus (MIC=1.25-2.5 ?M), S. epidermidis (MIC=5-10 ?M), S. saprophiticus (MIC=5-10 ?M), S. xylosus (MIC>20 ?M), Streptococcus agalactiae (MIC=1.25-2.5 ?M), S. bovis (MIC=1.25-2.5 ?M), S. equisimilis (MIC=2.5-5 ?M), S. mitis (MIC=1.25-2.5 ?M), Streptococcus pneumoniae (MIC=1.25-2.5 ?M), Streptococcus pyogenes (MIC=1.25-2.5 ?M), S. iniae KST740ak (MIC=1.25-2.5 ?M), S. iniae KSTSi 6P (MIC=1.25-2.5 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 ?M), Burkholderia cepacia (MIC>20 ?M), Vibrio cholera (MIC=2.5-5 ?M), Escherichia coli (MIC=5-10 ?M), Moraxella catarrhalis (MIC=2.5-5 ?M), Neisseria gonorrhoeae (MIC>20 ?M), Pseudomonas aeruginosa (MIC=5-10 ?M), Enterobacter cloacae (MIC=10-20 ?M), E. aerogenes (MIC=10-20 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), K. oxytoca (MIC=5-10 ?M), Salmonella choleraesuis (MIC=10-20 ?M), Salmonella typhimurium (MIC=10-20 ?M), S. arizonae (MIC=10-20 ?M), Serratia marcescens (MIC>20 ?M), Shigella flexneri (MIC=2.5-5 ?M), S. sonnei (MIC=5-10 ?M), Yersinia enterocolitica (MIC=2.5-5 ?M).##Fungi: Neurospora crassa (MIC=1.56-3.12 ?M), Aspergillus fumigatus (MIC=50-100 ?M), Fusarium oxysporum (MIC=0.78-1.56 ?M), F. culmorum (MIC=0.39-0.78 ?M), Candida albicans (MIC=10-20 ?M), C. glabrata (MIC=10-20 ?M), C. lusitania (MIC=10-20 ?M), C. tropicalis (MIC=10-20 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11739390	J Biol Chem. 2002 Feb 15;277(7):5030-5039.	"Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Shimizu C, Bulet P."	"Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass."
DRAMP02336	KAVAAKKSPKKAKKPATPKKAAKSPKKVKKPAAAAKKAAKSPKKATKAAKPKAAKPKAAKAKKAAPKKK	69	"Oncorhyncin II (Oncorhyncin 2; fish, chordates, animals)"	"P06350, P83374"	Belongs to the histone H1/H5 family	Not found	Oncorhynchus mykiss (Rainbow trout)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Potentially important role in mucosal defense. 	"Gram-positive bacteria: Planococcus citreus (MIC=0.2-0.4 ?M), Micrococcus luteus (MIC=0.2-0.4 ?M);##Gram-negative bacteria: Escherichia coli (MIC=0.4-0.8 ?M), Listonella anguillarum (MIC=0.4-0.8 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12969798	Dev Comp Immunol. 2004 Feb;28(2):127-138. 	"Fernandes JM, Molle G, Kemp GD, Smith VJ."	"Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss."
DRAMP02337	PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAG	66	"Oncorhyncin III (Oncorhyncin 3; fish, chordates, animals)"	"P02315, P83338"	Belongs to the HMGN family	Not found	Oncorhynchus mykiss (Rainbow trout)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Plays a role in mucosal innate host defence.	"Gram-positive bacteria: Aerococcus viridans (MIC=0.06-0.12 ?M), Bacillus subtilis (MIC=0.25-0.5 ?M), Micrococcus luteus (MIC=0.12-0.25 ?M), Planococcus citreus (MIC=0.06-0.12 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>0.5 ?M), Aeromonas salmonicida 004 (MIC>0.5 ?M), Escherichia coli (MIC=0.25-0.5 ?M), Listonella anguillarum (MIC=0.25-0.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	DNA	12713443	Biochem J. 2003 Jul 15;373(Pt 2):621-628.	"Fernandes J.M.O, Saint N, Kemp G.D, Smith V.J."	"Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss."
DRAMP02347	GKGRWLERIGKAGGIIIGGALDHL	24	"NRC-1 (fish, chordates, animals)"	No entry found	Not found	Not found	Pseudopleuronectes americanus (Winter flounder 1)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"C-terminal NH2, this NRC seris of peptides was identified by gene analysis and biological activity verified using synthetic peptides. "	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 ?g/ml), Aeromonas salmonicida 97-4 (MIC=64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), Escherichia coli UB1005 (MIC=32 ?g/ml), Escherichia coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC=64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02348	WLRRIGKGVKIIGGAALDHL	20	"NRC-2 (fish, chordates, animals)"	No entry found	Not found	Not found	Pseudopleuronectes americanus (Winter flounder 1a)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>128 ?g/ml), Aeromonas salmonicida 97-4 (MIC=128 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), E. coli UB1005 (MIC=64 ?g/ml), E. coli DC2 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02349	GRRKRKWLRRIGKGVKIIGGAALDHL	26	"NRC-3 (fish, chordates, animals)"	No entry found	Not found	Not found	Pseudopleuronectes americanus (Winter flounder 1a-1)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), Aeromonas salmonicida 97-4 (MIC=4 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), Escherichia coli UB1005 (MIC=8 ?g/ml), Escherichia coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=8 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02350	GWGSFFKKAAHVGKHVGKAALTHYL	25	"Pleurocidin (NRC-4; fish, chordates, animals)"	"P81941, P81619, Q9PRJ9, Q90ZY0, Q90VW6"	Belongs to the pleurocidin family	ple1 AND ple2	Pseudopleuronectes americanus (Winter flounder 2-2.1)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (1 helices; 19 residues)	"From NMR structural studies with the uniformly (15)N-labeled peptide, a structure of pleurocidin is determined to be in a random coil conformation in aqueous solution whereas it assumes an alpha-helical structure in TFE and in dodecylphosphocholine (DPC) micelles.(Ref.2)"	1Z64?resolved by NMR.	May play a role in innate host defense.	"Gram-negative bacteria: Escherichia coli (MIC=2.2-3.3 ?M), Leucothrix mucor (MIC>35.0 ?M), Serratia marcescens (MIC>35.0 ?M), Pseudomonas aeruginosa (MIC>35.0 ?M), Aeromonas salmonicida (MIC=17.7-35.0 ?M), Cytophaga aquatilis (MIC=2.2-4.4 ?M), Pasteurella haemolytica (MIC=4.4-8.8 ?M), Salmonella typhimurium I (MIC=8.8-17.7 ?M), Salmonella typhimurium II (MIC=8.8-17.7 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=1.1-2.2 ?M), Staphylococcus aureus (MIC=17.7-35.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9115266	J Biol Chem. 1997 May 2;272(18):12008-12013.	"Cole A.M, Weis P, Diamond G."	"Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder."
DRAMP02351	FFRLLFHGVHHVGKIKPRA	19	"NRC-10 (fish, chordates, animals)"	No entry found	Not found	Not found	Pseudopleuronectes americanus (Winter flounder Z)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), Aeromonas salmonicida 97-4 (MIC=32 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), Escherichia coli UB1005 (MIC=32 ?g/ml), Escherichia coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus C623 (MRSA) (MIC=64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02352	GWKKWLRKGAKHLGQAAIK	19	"NRC-16 (fish, chordates, animals)"	No entry found	Not found	Not found	Glyptocephalus cynoglossus (Witch flounder GC3.8-t)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=1 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=0.5 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=16 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=1 ?g/ml), E. coli UB1005 (MIC=2 ?g/ml), E. coli DC2 (MIC=0.5 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02354	FFRLLFHGVHHGGGYLNAA	19	"Pleurocidin-like peptide WFY (fish, chordates, animals)"	No entry found	Not found	Not found	Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida A449 field isolate (MIC>64 ?g/ml), A. salmonicida 97-4 field isolate (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC4908 triple (MIC=64 ?g/ml), Salmonella typhimurium 14028s (MIC>64 ?g/ml), Salmonella typhimurium MS7953s (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis (human clinical isolates) (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) (MIC>64 ?g/ml).##Fungi: Candida albica (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12950255	Eur J Biochem. 2003 Sep;270(18):3720-3730.	"Douglas SE, Patrzykat A, Pytyck J, Gallant JW."	"Identification, structure and differential expression of novel pleurocidins clustered on the genome of the winter flounder, Pseudopleuronectes americanus (Walbaum)."
DRAMP02357	FLGALIKGAIHGGRFIHGMIQNHH	24	"Pleurocidin-like peptide WF3 (NRC-5; fish, chordates, animals)"	Q90VW7	Belongs to the pleurocidin family	ple3	Pseudopleuronectes americanus (Winter flounder 3)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), Escherichia coli UB1005 (MIC=64 ?g/ml), Escherichia coli DC2 (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506##11113283	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.##Dev Comp Immunol. 2001 Mar;25(2):137-147.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.##Douglas SE, Gallant JW, Gong Z, Hew C."	"Novel antimicrobial peptides derived from flatfish genes.##Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum)."
DRAMP02358	GWGSIFKHGRHAAKHIGHAAVNHYL	25	"Pleurocidin-like peptide WF4 (NRC-6; fish, chordates, animals)"	"Q90ZX8, Q90ZX9"	Belongs to the pleurocidin family	ple4	Pseudopleuronectes americanus (Winter flounder 4-1.1)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=4 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=16 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC=32 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506##11113283	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.##Dev Comp Immunol. 2001 Mar;25(2):137-147.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.##Douglas SE, Gallant JW, Gong Z, Hew C."	"Novel antimicrobial peptides derived from flatfish genes.##Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum)."
DRAMP02359	RWGKWFKKATHVGKHVGKAALTAYL	25	"Pleurocidin-like peptide YT2 (NRC-7; fish, chordates, animals; Predicted)"	Q7SZH1	Not found	ple	Limanda ferruginea (Yellowtail flounder YT2)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=2 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=64 ?g/ml).##Yeast: Candida albicans C627 (MIC=16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02360	GWKSVFRKAKKVGKTVGGLALDHYLG	26	"Pleurocidin-like peptide AP1 (NRC-11; fish, chordates, animals; Predicted)"	Q7SZH4	Not found	ple	Hippoglossoides platessoides (American plaice AP1)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 ?g/ml), A. salmonicida 97-4 (MIC=8 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=32 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=16?g/ml), E. coli DC2 (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC=32 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02361	GWKKWFNRAKKVGKTVGGLAVDHYLG	26	"Pleurocidin-like peptide AP2 (NRC-12; fish, chordates, animals; Predicted)"	Q7SZH3	Not found	ple	Hippoglossoides platessoides (American plaice AP2)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), E. coli UB1005 (MIC=8 ?g/ml), E. coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: S. epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02362	GWRTLLKKAEVKTVGKLALKHYL	23	"Pleurocidin-like peptide AP3 (NRC-13; fish, chordates, animals; Predicted)"	Q7SZH2	Not found	ple	Hippoglossoides platessoides (American plaice AP3)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=2 ?g/ml).##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02363	AGWGSIFKHIFKAGKFIHGAIQAHND	26	"Pleurocidin-like peptide GcSc4C5 (NRC-14; fish, chordates, animals)"	Q7SZH0 	Not found	ple	Glyptocephalus cynoglossus (Witch flounder GcSc4C5)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=32 ?g/ml), A. salmonicida 97-4 (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=16 ?g/ml), E. coli UB1005 (MIC=16 ?g/ml), E. coli DC2 (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02364	GFWGKLFKLGLHGIGLLHLHL	21	"Pleurocidin-like peptide GcSc4B7 (NRC-15; fish, chordates, animals; Predicted)"	Q7SZG9	Not found	ple	Glyptocephalus cynoglossus (Witch flounder GcSc4B7)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 ?g/ml), A. salmonicida 97-4 (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=16 ?g/ml), Pseudomonas aeruginosa K799 (MIC=8 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=8 ?g/ml), E. coli UB1005 (MIC=8 ?g/ml), E. coli DC2 (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 ?g/ml).##Yeast: Candida albicans C627 (MIC=16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02365	GWKKWLRKGAKHLGQAAIKGLAS	23	"Pleurocidin-like peptide GC3.8 (NRC-17; fish, chordates, animals; Predicted)"	Q7SZG8	Not found	ple	Glyptocephalus cynoglossus (Witch flounder GC3.8)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=1 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=1 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=2 ?g/ml), Escherichia coli CGSC 4908 (MIC=1 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02366	GWKKWFTKGERLSQRHFA	18	"Pleurocidin-like peptide GC3.2 (NRC-18; fish, chordates, animals; Predicted)"	Q7SZG7	Not found	ple	Glyptocephalus cynoglossus (Witch flounder GC3.2)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC=128 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=32 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), E. coli UB1005 (MIC=64 ?g/ml), E. coli DC2 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02367	FLGLLFHGVHHVGKWIHGLIHGHH	24	"Pleurocidin-like peptide Hb26 (NRC-19; fish, chordates, animals; Predicted)"	Q7SZG6	Not found	ple	Hippoglossus hippoglossus (Halibut Hb26)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), E. coli UB1005 (MIC=16 ?g/ml), E. coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=8 ?g/ml).##Yeast: Candida albicans C627 (MIC=64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02368	GFLGILFHGVHHGRKKALHMNSERRS	26	"Pleurocidin-like peptide Hb18 (NRC-20; fish, chordates, animals; Predicted)"	Q7SZG5	Not found	ple	Hippoglossus hippoglossus (Halibut Hb18)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC>64 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC 4908 (MIC>64 ?g/ml), E. coli UB1005 (MIC>64 ?g/ml), E. coli DC2 (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12878506	Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.	"Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE."	Novel antimicrobial peptides derived from flatfish genes.
DRAMP02374	GCRFCCNCCPNMSGCGVCCRF	21	"Bass hepcidin (fish, chordates, animals)"	P82951	Belongs to the hepcidin family	hamp	Morone chrysops x Morone saxatilis (white bass x striped sea-bass)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Protein level	Beta strand (2 strands; 6 residues)	"Solution structure by NMR indicates that bass hepcidin is very similar to that of human hepcidin, including the presence of an antiparallel beta-sheet, a conserved disulfide-bonding pattern, and a rare vicinal disulfide bond."	1S6W resolved by NMR.	"Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity). Synthetic bass hepcidin is active in vitro against Gram-negative pathogens and fungi but showes no activity against key Gram-positive pathogens and a single yeast strain tested.
Tissue specificity: Predominantly expressed in liver.
Induction: By bacterial challenge.
PTM: Contains four disulfide bonds 2-19; 5-8; 6-15; 9-18."	"Gram-negative bacteria: Escherichia coli ATCC 25,922,351,50 (MIC=22 ?M), Escherichia coli ATCC D31K (MIC=11 ?M), Klebsiella pneumoniae ATCC 10,031 (MIC=22 ?M), P. shigelloides ATCC KST (MIC=11 ?M), S. flexneri ATCC 12,022 (MIC=22 ?M), Shigella sonnei ATCC 9290 (MIC=44 ?M), Y. enterocolitica ATCC 23,715 (MIC=22 ?M).##Fungi: Aspergillus niger (MIC=44 ?M)."	[Ref.15546886] It displays essentially no hemolytic activity toward HSB erythrocytes	Cyclic	Free	Free	"Disulfide bonds between Cys2 and Cys19; Cys5 and Cys8; Cys6 and Cys15,Cys9 and Cys18."	L	No cytotoxicity information found	Not found	11985602##15546886	Eur J Biochem. 2002 Apr;269(8):2232-2237.##J Biol Chem. 2005 Mar 11;280(10):9272-9282.	"Shike H, Lauth X, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Shimizu C, Bulet P, Burns JC.##Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME."	"Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge.##Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections."
DRAMP02376	LFGFLIKLIPSLFGALSNIGRNRNQ	25	"Grammistin Gs 1 (Grammistin Gs F; Group I grammistin; soapfish, chordates, animals)"	P69835	Belongs to the grammistin family (Group 1 subfamily)	Not found	Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=12.5 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=12.5 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Fish. Sci. 2001 Oct;67:928-933.	"Yokota H, Nagashima Y, Shiomi K."	Interaction of grammistins with lipids and their antibacterial activity.
DRAMP02377	LFGFLIPLLPHIIGAIPQVIGAIR	24	"Grammistin Gs 2 (Grammistin Gs G; Group I grammistin; soapfish, chordates, animals)"	P69836	Belongs to the grammistin family (Group 1 subfamily)	Not found	Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=12.5 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), Photobacterium damselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=25 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Fish. Sci. 2001 Oct;67:928-933.	"Yokota H, Nagashima Y, Shiomi K."	Interaction of grammistins with lipids and their antibacterial activity.
DRAMP02378	WWRELLKKLAFTAAGHLGSVLAAKQSGW	28	"Grammistin Gs A (Group III grammistin; soapfish, chordates, animals)"	P69845	Belongs to the grammistin family (Group 3 subfamily)	Not found	Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15777955	Toxicon. 2005 Apr;45(5):595-601.	"Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K."	Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus.
DRAMP02379	IGGIISFFKRLF	12	"Grammistin Gs B (Group II grammistin; soapfish, chordates, animals)"	P69839	Belongs to the grammistin family (Group 2 subfamily)	Not found	Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=12.5 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC=12.5 ?g/ml), S. putrefaciens IAM 1509 (MIC=3.13 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=6.25 ?g/ml), Vibrio parahaemolyticus (MIC=12.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15777955	Toxicon. 2005 Apr;45(5):595-601.	"Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K."	Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus.
DRAMP02380	NWRKILGKIAKVAAGLLGSMLAGYQV	26	"Grammistin Gs C (Group III grammistin; soapfish, chordates, animals)"	P69846	Belongs to the grammistin family (Group 3 subfamily)	Not found	Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"MOA: Thanks to its amphiphilic alpha-helice(s), it may integrate into membrane phospholipids, leading to lysis of the membrane."	"Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=12.5 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC=12.5 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15777955	Toxicon. 2005 Apr;45(5):595-601.	"Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K."	Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus.
DRAMP18373	CMSYGGSCQRSCNGGFRLGGHCGHPKIRCCRRK	33	mBD-6 (Murine beta-defensin 6)	No entry found	Belongs to the beta-defensin family.	Not found	Mus musculus	"Antimicrobial, Antibacterial, Anti-Gram-"		bridge	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacteria: E. coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11408484	J Biol Chem. 2001 Aug 24;276(34):31510-4	"Yamaguchi Y, Fukuhara S, Nagase T, Tomita T, Hitomi S, Kimura S, Kurihara H, Ouchi Y."	"A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle."
DRAMP18374	FFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCCRTIQPSGSIID	45	hBD-6 (human beta-defensin 6)	No entry found	Belongs to the beta-defensin family.	Not found	Homo sapiens	"Antimicrobial, Antibacterial, Anti-Gram-, Chemotactic"		beta 	Not found	2LWL 	Comment: No comments found on DRAMP database	Gram-negative bacteria: E. coli K12.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12193721	J Immunol. 2002 Sep 1;169(5):2516-23	"Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y."	Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.
DRAMP02390	RPRPNYRPRPIYRP	14	"Astacidin 2 (crayfish, Arthropods, animals)"	Q0PJU7	Not found	Not found	Pacifastacus leniusculus (signal crayfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Rich	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Shigella flexneri ATCC 203 (MIC=0.98 ?g/ml), Proteus vulgaris OX19 ATCC 6380 (MIC=7.8 ?g/ml), Escherichia coli D21 (MIC=3.9 ?g/ml), Psedomonas aeruginosa OT 97 (MIC=7.8 ?g/ml).##Gram-positive bacteria: Bacillus megateriun B11 (MIC=1.9 ?g/ml), Bacillus subtilis ATCC 6633 (MIC=1.95 ?g/ml), Staphylococcus aureus JC-1 (MIC=7.8 ?g/ml), Micrococcus luteus Ml 11 (MIC=10 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17049601	Dev Comp Immunol. 2007;31(5):441-455. 	"Jiravanichpaisal P, Lee SY, Kim YA, Andr¨¦n T, S?derh?ll I."	Antibacterial peptides in hemocytes and hematopoietic tissue from freshwater crayfish Pacifastacus leniusculus: characterization and expression pattern.
DRAMP02391	GWFKKAWRKVKHAGRRVLDTAKGVGRHYLNNWLNRYRG	38	"Hematopoietic antimicrobial peptide-37 (MgCath37; hagfishes, chordates, animals)"	Q71MD7	Not found	CATH37	Myxine glutinosa (Atlantic hagfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Propionibacterium acnes ATCC 11827 and 33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081 and 13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771, 43935, 12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15019197	Peptides. 2003 Nov;24(11):1655-1667.	"Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M."	Hagfish intestinal antimicrobial peptides are ancient cathelicidins.
DRAMP02393	GFFKKAWRKVKHAGRRVLDTAKGVGRHYVNNWLNRYRZ	38	"HFIAP-1 (HFIAP-2; hagfishes, chordates, animals)"	No entry found	Not found	Not found	Myxine glutinosa (Atlantic hagfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species.
Sequence similarity: Sequences for HFIAP-1 and -2 are identical, but HFIAP-2 is brominated only at residue 7; they differ from MgCath37 by conservative replacements."	"Gram-positive bacteria: Propionibacterium acnes ATCC 11827/33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081/13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771/43935/12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15019197	Peptides. 2003 Nov;24(11):1655-1667.	"Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M."	Hagfish intestinal antimicrobial peptides are ancient cathelicidins.
DRAMP02394	GWFKKAWRKVKNAGRRVLKGVGIHYGVGLIZ	31	"HFIAP-3 (hagfishes, chordates, animals)"	No entry found	Not found	Not found	Myxine glutinosa (Atlantic hagfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species. HFIAP-1 and HFIAP-3 exhibit similar inhibitory activity.	"Gram-positive bacteria: Propionibacterium acnes ATCC 11827/33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081/13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771/43935/12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15019197	Peptides. 2003 Nov;24(11):1655-1667.	"Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M."	Hagfish intestinal antimicrobial peptides are ancient cathelicidins.
DRAMP02395	AACSDRAHGHICESFKSFCKDSGRNGVKLRANCKKTCGLC	40	"Aurelin (jellyfish, chordates, animals)"	"Q0MWV8, P84891"	Belongs to ShKT domain family	Not found	Aurelia aurita (Moon jellyfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	Not found	2LG4 resolved by NMR.	"Function: Antimicrobial peptide exhibits activity against Gram-positive and Gram-negative bacteria.
Domian: Contains 1 ShKT domain.
PTM: Contains three disulfide bonds (By similarity)."	Gram-positive bacterium: Listeria monocytogenes EGD (MIC=22.64 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35p (MIC=7.66 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys19 and Cys40)	Disulfide bonds between Cys3 and Cys33; Cys12 and Cys37; Cys19 and Cys40.	L	No cytotoxicity information found	Not found	16890198##PubMed ID is not available 	Biochem Biophys Res Commun. 2006 Sep 22;348(2):514-523.##To be Published.	"Ovchinnikova TV, Balandin SV, Aleshina GM, Tagaev AA, Leonova YF, Krasnodembsky ED, Men'shenin AV, Kokryakov VN.##Shenkarev Z, Altukhov D, Gizatullina A, Arseniev A, Ovchinnikova T."	"Aurelin, a novel antimicrobial peptide from jellyfish Aurelia aurita with structural features of defensins and channel-blocking toxins.##Solution structure of aurelin, a novel antimicrobial peptide."
DRAMP02397	AVPDVAFNAYG	11	Big defensin (RPD-1)	P86316	Belongs to the big defensin family	Not found	Venerupis philippinarum (Japanese carpet shell) (Tapes japonica)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Protein level	Not found	Not found	None	Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro. Has antibacterial activity.	"Gram-positive bacteria: Staphylococcus aureus (MIC=9.6 mg/L), Bacillus subtilis (MIC=76.8 mg/L), Micrococcus tetragenus (MIC=38.4 mg/L);##Gram-negative bacteria: Escherichia coli (MIC=76.8 mg/L), Vibrio parahaemolyticus (MIC=19.2 mg/L), Vibrio anguillarum (MIC=19.2 mg/L)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14673509	Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Dec;35(12):1145-8.	"Wei YX, Guo DS, Li RG, Chen HW, Chen PX."	Purification of a big defensin from Ruditapes philippinesis and its antibacterial activity.
DRAMP02402	FLPKMSTKLRVPYRRGTKDYH	21	Antimicrobial peptide scolopin-1	P0CH48	Not found	Not found	Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide against both Gram-positive, Gram-positive and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells.
Tissue specificity: Expressed by the venom gland."	"[Ref.19716842]Gram-negative bacteria: Escherichia coli standard strain (MIC=12.5 ?g/ml), E. coli drug-resistant strain (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=1.2 ?g/ml), S. aureus drug-resistant strain (MIC=5.0 ?g/ml), Bacillus dysenteriae standard and drug-resistant strains (MIC=7.5 ?g/ml);##Yeast: Candida albicans (MIC=15 ?g/ml)."	[Ref.19716842]25 ¡À 2% hemolytic activity at 50 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19716842	Toxicon. 2010 Feb-Mar;55(2-3):274-279.	"Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H."	Two novel antimicrobial peptides from centipede venoms.
DRAMP02403	GILKKFMLHRGTKVYKMRTLSKRSH	25	Antimicrobial peptide scolopin-2	P0CH49	Not found	Not found	Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide against both Gram-positive, -negative and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells.
Tissue specificity: Expressed by the venom gland."	"[Ref.19716842]Gram-negative bacteria: Escherichia coli standard and drug-resistant strains (MIC=5.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=0.5 ?g/ml), S. aureus drug-resistant strain (MIC=1.0 ?g/ml), Bacillus dysenteriae standard strain (MIC=2.5 ?g/ml), B. dysenteriae drug-resistant strain (MIC=5.0 ?g/ml);##Yeast: Candida albicans (MIC=7.5 ?g/ml)."	[Ref.19716842]32 ¡À 7% hemolytic activity at 50 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19716842	Toxicon. 2010 Feb-Mar;55(2-3):274-279.	"Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H."	Two novel antimicrobial peptides from centipede venoms.
DRAMP02409	GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF	34	M-theraphotoxin-Gr1a (M-TRTX-Gr1a; GsMTx-4)	"Q7YT39, Q7M3T1"	Belongs to the huwentoxin-1 family	Not found	Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Beta strand (5 strands; 9 residues)	Not found	"1LU8, 1TYK resolved by NMR."	"Function: This cationic hydrophobic peptide inhibits a lot of different channels and has an antimicrobial activity. It blocks mechanosensitive ion channels (also named stretch-activated channels or SACs), without having effect on whole-cell voltage-sensitive currents. Acts by partitioning into the membrane and perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. Inhibits atrial fibrillation as well as the membrane motor of outer hair cells at low doses. GsMTx-4 exhibites antimicrobial properties and was more active against Gram-positive than Gram-negative bacteria.
Tissue specificity: Expressed by the venom gland.
Miscellaneous: This toxin does not inhibit potassium channels Kv1.1/KCNA1 (IC50>85 ?M), Kv1.4/KCNA4 (IC50>85 ?M) and Kv11.3/KCNH7 (IC50=53 ?M).
PTM: Contains three disulfide bonds."	"Gram-positive bacteria: Bacillus subtilis (MIC=0.5 ?M), Staphylococcus aureus (MIC=2-4 ?M), Staphylococcus epidermidis (MIC=4-8 ?M);##Gram-negative bacteria: Salmonella typhimurium (MIC=32.64 ?M), Pseudomonas aeruginosa (MIC=8-16 ?M), Escherichia coli (MIC=8-16 ?M). "	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys2 and Cys17,Cys9 and Cys23,Cys16 and Cys30."	L	No cytotoxicity information found	Not found	PubMed ID is not available##12082099##10779316##163768	Submitted (MAY-2002) to the PDB data bank##J Biol Chem. 2002 Sep 13;277(37):34443-50.##J Gen Physiol. 2000 May;115(5):583-598.##Biochem Biophys Res Commun. 2006 Feb 10;340(2):633-638.	"Jung HJ, Lee CW, Earm YE, Kim JI.##Oswald RE, Suchyna TM, McFeeters R, Gottlieb P, Sachs F.##Suchyna TM, Johnson JH, Hamer K, Leykam JF, Gage DA, Clemo HF, Baumgarten CM, Sachs F.##Jung HJ, Kim PI, Lee SK, Lee CW, Eu YJ, Lee DG, Earm YE, Kim JI."	"Solution structure of GsMTx-4, a peptide blocker of cation-selective stretch-activated channels.##Solution structure of peptide toxins that block mechanosensitive ion channels.##Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.##Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel."
DRAMP02410	FSKYERQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIKWNEEGLPIYEIPGEGGHAEPAAA	62	Antimicrobial peptide lumbricin-1 	O96447	Not found	Not found	Lumbricus rubellus (Humus earthworm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Displays antimicrobial activity and weak hemolytic activity.
Developmental stage: Adult-specific. Not detected in eggs or 1-week-old worms but abundant in 6-month-old worms.
Induction: Constitutively expressed. Not induced by bacterial infection."	"[Ref.9784609]Gram-positive bacteria: Bacillus subtilis ATCC 62037 (MIC=12 ?g/ml), Staphylococcus aureus ATCC 15752 (MIC=16 ?g/ml), Streptococcus mutans ATCC 25175 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 27325 (MIC=12 ?g/ml), Pseudomonas putidaATCC 17426 (MIC=16 ?g/ml), Serratia sp. ATCC 21074 (MIC=16 ?g/ml);##Fungi: Candida albicans ATCC 10231 (MIC=16 ?g/ml), Cryptococcus neoformance ATCC 34881 (MIC=25 ?g/ml), Saccharomyces cerevisiae ATCC 44774 (MIC=12 ?g/ml).##NOTE: Minimal inhibitory concentrations were determined by incubating approximately 104¨C105 CFU/ml of cells with serial dilutions of each peptide in a 96-well microtiter plate."	"[Ref.9784609]0.02% hemolytic activity at 5 ¦Ìg/ml, 0.06% hemolytic activity at 10 ¦Ìg/ml, 0.14% hemolytic activity at 25 ¦Ìg/ml, 0.19% hemolytic activity at 50 ¦Ìg/ml, 0.23% hemolytic activity at 100 ¦Ìg/ml against human erythrocytes "	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9784609	Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76.	"Cho JH, Park CB, Yoon YG, Kim SC."	"Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization."
DRAMP02411	GHLGRPYIGGGGGFNRGGGFHRGGGFHRGGGFHSGGGFHRGGGFHSGGSFGYR	53	Armadillidin (Glyc-rich)	Q64HC7	Not found	Not found	Armadillidium vulgare (Pillbug) (Pill woodlouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive bacterium B. megaterium LM101.
Tissue specificity: Expressed in hemocytes and at very low levels in ovary. Not expressed in adipose tissue, brain, caecum, gut, heart and nervous chain.
PTM C-terminal amidation."	"Gram-positive bacteria: Bacillus megaterium LM101 (MIC=0.5-1.25 ?M), Enterococcus faecalis LM002, Micrococcus luteus LM610, Listeria ivanovii BUG496;##Gram-negative bacteria: Escherichia coli JM83, Salmonella thyphimurium LM122, Enterobacter cloacae LM111, Citrobacter freundii LM457.##NOTE: Because of the low amount of the purified peptide, this minimal concentration activity is only tested on B. megaterium."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15752546	Dev Comp Immunol. 2005;29(6):489-499.	"Herbini¨¨re J, Braquart-Varnier C, Gr¨¨ve P, Strub JM, Fr¨¨re J, Van Dorsselaer A, Martin G."	"Armadillidin: a novel glycine-rich antibacterial peptide directed against Gram-positive bacteria in the woodlouse Armadillidium vulgare (terrestrial isopod, crustacean)."
DRAMP02412	SYVGDCGSNGGSCVSSYCPYGNRLNYFCPLGRTCCRHAYV	40	"Panusin (Defensin-like peptide 7, PaD7) "	F6KSI8	Belongs to the beta-defensin family	Not found	Panulirus argus (Caribbean spiny lobster) (Palinurus argus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide. Has antibacterial activity.
PTM: Contains two disulfide bonds (By similarity)."	Gram-positive bacterium: Staphylococcus aureus ATCC 29737 (MIC=3.46 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=4.8 ?M).	[Ref.27616720] It shows no hemolytic effect on human red blood cells	Cyclic	Free	Free	"Disulfide bonds between Cys6 and Cys28,Cys13 and Cys34,Cys18 and Cys35."	L	No cytotoxicity information found	Not found	22885029##PubMed ID is not available	Fish Shellfish Immunol. 2012 Oct;33(4):872-879.##Submitted (FEB-2012) to UniProtKB	"Montero-Alejo V, Acosta-Alba J, Perdomo-Morales R, Perera E, Hern¨¢ndez-Rodr¨ªguez EW, Estrada MP, Porto-Verdecia M.##Montero-Alejo V, Pacios-Michelena A, Perdomo-Morales R, Crozo G, Vega-Hurtado Y."	"Defensin like peptide from Panulirus argus relates structurally with beta defensin from vertebrates.##Panusin, a new defensin-like antimicrobial peptide from the hemocytes of spiny lobster Panulirus argus."
DRAMP02421	ACHAHCQSVGRRGGYCGNFRMTCYCY	26	"Hlgut-defensin (H. longicornis midgut defensin; Ticks, Arthropods, animals)"	A4GUC3	Not found	Not found	Haemaphysalis longicornis (Bush tick)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	"Function: Both Hlgut-defensin and Hlsal-defensin sequences have antibactrrial activity against a variety of Gram-positive and Gram-negative bacteria.
Induction: By a lipopolysaccharide (LPS) injection."	Gram-positive bacterium: Staphylococcus aureus (MIC=5-25 mg/mL);##Gram-negative bacterium: Escherichia coli (MIC=10-25 mg/mL).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17521774	Peptides. 2007 Jun;28(6):1304-1310.	"Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K."	Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis.
DRAMP02422	NCIQQCVSKGAQGGYCTNEKCTCY	24	"Hlsal-defensin (H. longicornis salivary gland defensin; Ticks, Arthropods, animals)"	A4GUC4	Not found	Not found	Haemaphysalis longicornis (Bush tick)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	"Function: Both Hlgut-defensin and Hlsal-defensin sequences have antibactrrial activity against a variety of Gram-positive and Gram-negative bacteria.
Induction: By a lipopolysaccharide (LPS) injection."	Gram-positive bacterium: Staphylococcus aureus (MIC=5-25 mg/mL);##Gram-negative bacterium: Escherichia coli (MIC=10-25 mg/mL).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17521774	Peptides. 2007 Jun;28(6):1304-1310.	"Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K."	Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis.
DRAMP02423	DFGCARGMIFVCMRRCARMYPGSTGYCQGFRCMCDTMIPIRRPPFIMG	48	"HlMS-defensin (Ticks, Arthropods, animals)"	No entry found	Not found	Not found	Haemaphysalis longicornis (Tick)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=18.8 ?g/ml), Bacillus licheniformis (MIC=9.4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=28.1 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=37.5 ?g/ml), Serratia rubidaea (MIC=28.1 ?g/ml), Psychrobacter faecalis (MIC=2.3 ?g/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22033149	Dev Comp Immunol. 2012 May;37(1):207-211.	"Zheng H, Zhou L, Yang X, Wang D, Liu J."	Cloning and characterization of a male-specific defensin-like antimicrobial peptide from the tick Haemaphysalis longicornis.
DRAMP02425	QLKVDLWGTRSGIQPEQHSSGKSDVRRWRSRY	32	"Ixosin-B (Ticks, Arthropods, animals)"	A7UDM9	Not found	Not found	Ixodes sinensis (Hard tick)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antifungal and antibacterial activity. Ixosin-B has little hemolytic activity on red blood cells even with peptide
concentrations up to 200 ?g/mL."	[Ref.18295522]Gram-positive bacterium: Staphylococcus aureus (MIC=2.5 ?g/mL);##Gram-negative bacterium: Escherichia coli (MIC=15 ?g/mL);##Yeast: Candida albicans (MIC=7.5 ?g/mL).	[Ref.18295522]Little hemolytic activity on rabbit red blood cells up to 200 ¦Ìg/mL	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18295522	Comp Biochem Physiol B Biochem Mol Biol. 2008 Apr;149(4):557-561.	"Liu Z, Liu H, Liu X, Wu X."	"Purification and cloning of a novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis."
DRAMP02430	GLHKVMREVLGYERNSYKKFFLR	23	"Ixosin (Ticks, Arthropods, animals)"	Q2LKX9	Not found	Not found	Ixodes sinensis (Hard tick)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has antifungal activity against C. albicans. Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Little hemolytic activity against rabbit erythrocytes.	[Ref.16087274]Gram-postive bacteria: Staphylococcus aureus (MIC=3.7 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=30 ?g/ml);##Fungi: Candida albicans (MIC=7.5 ?g/ml).	[Ref.16087274]Little hemolytic activity on rabbit red blood cells up to 50 ¦Ìg/mL	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16087274	Peptides. 2006 Jan;27(1):31-5.	"Yu D, Sheng Z, Xu X, Li J, Yang H, Liu Z, Rees HH, Lai R."	"A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis."
DRAMP02432	PDPGQPWQVKAGRPPCYSIPCRKHDECRVGSCSRCNNGLWGDRTCR	46	"Antimicrobial peptide ISAMP (Ticks, Arthropods, animals)"	Q8MVA6	Not found	Not found	Ixodes scapularis (Black-legged tick) (Deer tick)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity and weak hemolytic.
Tissue specificity: Expressed in the fat body, hemocytes and salivary glands of partially-fed female ticks. Not expressed in the midgut."	"[Ref.19852941]Gram-positive bacteria: Bacillus cereus (MIC=5.8 ?g/ml), Bacillus subtilis (MIC=12.3 ?g/ml), Staphylococcus aureus (MIC=10.4 ?g/ml);##Gram-negative bacteria: Escherichia coli Edl 933 (MIC=3.2 ?g/ml), E. coli MG/655 (MIC=4.2 ?g/ml)."	[Ref.19852941]Insignificant hemolytic activity even up to 150 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12177149##19852941	J Exp Biol. 2002 Sep;205(Pt 18):2843-2864.##Biochem Biophys Res Commun. 2009 Dec 18;390(3):511-515.	"Valenzuela JG, Francischetti IM, Pham VM, Garfield MK, Mather TN, Ribeiro JM.##Pichu S, Ribeiro JM, Mather TN."	"Exploring the sialome of the tick Ixodes scapularis.##Purification and characterization of a novel salivary antimicrobial peptide from the tick, Ixodes scapularis."
DRAMP02434	FSRYARMRDSRPWSDRKNNYSGPQFTYPPEKAPPEKLIKWNNEGSPIFEMPAEGGHIEP	59	Antimicrobial peptide lumbricin-PG (Lumbricin-PG)	P86929	Not found	Not found	Pheretima guillelmi (Earthworm) (Metaphire guillelmi)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Displays stronger activity against P. aeruginosa and S. aureus than E. coli. At the concentration of 200 g/ml, it induces 1.5 and 2.1% hemolysis of human and rabbit red blood cells, respectively."	"Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=2.5 ?g/m).##Fungi: Candida albicans ATCC 2002."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21539875	Peptides. 2011 Jun;32(6):1146-1150.	"Li W, Li S, Zhong J, Zhu Z, Liu J, Wang W."	"A novel antimicrobial peptide from skin secretions of the earthworm, Pheretima guillelmi (Michaelsen)."
DRAMP02445	LYKLVKVVLNM	11	Antimicrobial protein BL-A60	B3EWC5	Not found	Not found	Brevibacillus laterosporus (Bacillus laterosporus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial and antifungal activity. In P.capsici, inhibits mycelial growth (EC50=7.89 ?g/ml), formation of sporangia (EC50=0.6 ?g/ml) and cytospore germination (EC50=21.96 ?g/ml).
PTM: Contains a choline moiety at the N-terminus and a tenuazonic acid moiety at the C-terminus.
Biophysicochemical properties: pH dependence (Active between pH 3 and 11); Temperature dependence (Retains >80% activity after 15 min at 100 degrees Celsius)."	"Gram-negative bacterium: Pseudomonas solanacearum (MIC=10 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=5 ?M).##Fungi: Phytophthora capsici (MIC=15 ?M), Botrytis cinerea (MIC=25 ?M), Verticillium dahliae (MIC=200 ?M), Fusarium oxysporum (MIC=50 ?M), Xerocomus vesicolor (MIC=100 ?M). "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22244810	Peptides. 2012 Feb;33(2):206-211.	"Zhao J, Guo L, Zeng H, Yang X, Yuan J, Shi H, Xiong Y, Chen M, Han L, Qiu D."	Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60.
DRAMP02446	YSKSLPLSVLNP	12	Antimicrobial protein 1 (Antimicrobial protein AN5-1)	B3EWQ6	Not found	Not found	Paenibacillus alvei (Bacillus alvei)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has a broad inhibitory spectrum against both Gram-positive and -negative bacterial strains.
Miscellaneous: A synthetic peptide has no antibacterial activity against S. agalactiae ATCC 12386, S. epidermidis, P. aeruginosa and methicillin-resistant S. aureus (MRSA).
Biophysicochemical properties: pH dependence (Active between pH 2 and 12); Temperature dependence (Active between 37 and 90 degrees Celsius. Activity is reduced at 100 degrees Celsius and absent at 110 degrees Celsius. Activity is unaffected by storage at -20 degrees Celsius)."	"Gram-positive bacteria: Lactobacillus plantarum strain ATCC 8014 (MIC=32 ?g/ml), Lactococcus lactis ATCC 11454 (MIC>128 ?g/ml), Bacillus cereus strain ATCC 14579 (MIC=64 ?g/ml), Staphylococcus aureus (MIC=64 ?g/ml), Bacillus subtilis (MIC=32 ?g/ml), Bacillus anthracis (MIC=128 ?g/ml) and Bacillus licheniformis (MIC>128 ?g/ml), Bacillus ?exus (MIC=32 ?g/ml);##Gram-negative bacteria: Escherichia coli strain ATCC 13076 (MIC=8 ?g/ml), Salmonella enteritidis ATCC 13076 (MIC=4 ?g/ml), Enterobacter spp. (MIC=16 ?g/ml), Serratia marcescens (MIC=32 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23508455	J Ind Microbiol Biotechnol. 2013 Jun;40(6):571-579.	"Alkotaini B, Anuar N, Kadhum AA, Sani AA."	Detection of secreted antimicrobial peptides isolated from cell-free culture supernatant of Paenibacillus alvei AN5.
DRAMP02470	SCTTCECCCSCS	12	Nosiheptide (NOS; Antibiotic 9671-RP)	C6FX52	Belongs to the thiocillin family	nosM	Streptomyces actuosus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Inhibits bacterial protein biosynthesis by binding to ribosomes. Specifically, binds to the complex of 23S rRNA and ribosomal protein L11 (RPLK) in the 50S ribosomal subunit. While allowing a weak binding of elongation factor G (EF-G) to the ribosome and subsequent GTP-hydrolysis, probably impairs conformational changes in both the ribosome and EF-G which are necessary for translocation. In vitro, inhibits a variety of Gram-positive bacteria and inhibits Gram-negative bacterium P. multocida strain A125 (MIC=0.0024 ?g/ml). Does not inhibit Gram-negative bacterium E. coli strain ATCC 9637 but does inhibit purified ribosomes from E. coli. In vivo, has no systemic effect in mice infected with staphylococci or streptococci when applied orally or subcutaneously. Has a local effect in mice infected subcutaneously or intraperitoneally with staphylococci when applied immediately afterwards. Is not toxic to mice.
Miscellaneous: The mature peptide is identical to multhiomycin from S. antibioticus strain 8446CC1 (PMID 681244). Used as an antibiotic growth promotant in poultry and pig farming in parts of Asia."	"Gram-positive bacteria: Staphylococcus aureus strain 209P (MIC=0.0009 ?g/ml), S. aureus strain 133 (MIC=0.0019 ?g/ml), S. aureus strain B3 (MIC=0.003 ?g/ml), S. aureus strain Hb (MIC=0.003 ?g/ml), Micrococcus citreus strain ATCC 8411 (MIC=0.0038 ?g/ml), M. lysodeikticus strain ATCC 4698 (MIC=0.003 ?g/ml), Sarcina Lutea strain ATCC 9341 (MIC=0.0011 ?g/ml), Streptococcus faecalis strain ATCC 9790 (MIC=0.0007 ?g/ml), S. viridans (MIC=0.0065 ?g/ml), Streptococcus pyogenes hemolyticus strain Dig7 (MIC=0.00028 ?g/ml), Diplococcus pneumoniae strain Til (MIC=0.00015 ?g/ml), N. catrrhalis (MIC=0.0017 ?g/ml), Lactobacillus casei strain ATCC 6633 (MIC=0.003 ?g/ml), Bacillus cereus ATCC 6630 (MIC=0.0071 ?g/ml) and various isolates of Listeria monocytogenes.##Gram-negative bacterium: P. multocida strain A125 (MIC=0.0024 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19678698##18406324	ACS Chem Biol. 2009 Oct 16;4(10):855-864.##Mol Cell. 2008 Apr 11;30(1):26-38.	"Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W.##Harms JM, Wilson DN, Schluenzen F, Connell SR, Stachelhaus T, Zaborowska Z, Spahn CM, Fucini P."	Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.##Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.
DRAMP02473	KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF	30	"Cathelicidin-BF (Cathelicidin-related protein; Snakes, reptiles, animals)"	B6D434	Not found	Not found	Bungarus fasciatus (Banded krait)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane. No hemolytic and cytotoxic activities have been observed on mammalian cells.
Tissue specificity: Expressed by the venom gland, stomach, trachea, skin, muscle, heart, kidney, lung, brain, intestine, spleen, liver, and ovary.
Miscellaneous: A predicted cleavage site is located at position Val-157-158-Lys, giving a peptide of 34 residues instead of the 30 residues found for the purified protein. The 30 residues cathelicidin-BF could result from a further processing."	"[Ref.18795096]Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=1.2 ?g/ml), P. aeruginosa IS/DR (MIC=2.3 ?g/ml), P. aeruginosa 08031205 IS/DR (MIC=9.4 ?g/ml), P. aeruginosa 08031014 IS/DR (MIC=18.7 ?g/ml), Escherichia coli ATCC25922 (MIC=2.3 ?g/ml), E. coli 08A852 IS/DR (MIC=1.2 ?g/ml), E. coli 08A866 IS/DR (MIC=0.6 ?g/ml), E. coli 08031017 IS/DR (MIC=2.3 ?g/ml), E. coli 08032813 IS/DR (MIC=2.3 ?g/ml), E. coli 08040726 IS/DR (MIC=0.6 ?g/ml), E. coli 08040722 IS/DR (MIC=0.6 ?g/ml), Klebsiella pneumoniae IS/DR (MIC=4.7 ?g/ml), K. pneumoniae 08031012 IS/DR (MIC=9.4 ?g/ml), K. pneumoniae 08040202 IS/DR (MIC=0.6 ?g/ml), K. pneumoniae 08040724 IS/DR (MIC=0.3 ?g/ml), Pseudomonas luteola (MIC=1.2 ?g/ml), Salmonella Typhi IS/DR (MIC=1.2 ?g/ml), Acinetobacter calcoaceticus (MIC=2.3 ?g/ml), Sphingobacterium siyangense (MIC=9.4 ?g/ml), Saccharibacillus kuerlensis (MIC=4.7 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=9.4 ?g/ml), B. pumilus (MIC=9.4 ?g/ml), B. cereus (MIC=1.2 ?g/ml), Staphylococcus aureus ATCC2592 (MIC=4.7 ?g/ml), S. aureus 08A875 IS/DR (MIC=75 ?g/ml), S. aureus 08031002 IS/DR (MIC>100 ?g/ml), S. aureus 08031013 IS/DR (MIC>100 ?g/ml), S. aureus 08032706 IS/DR (MIC>100 ?g/ml), S. aureus 08032712 IS/DR (MIC>100 ?g/ml), S. aureus 08032810 IS/DR (MIC>100 ?g/ml), Enterococcus faecium IS/DR (MIC=150 ?g/ml);##Fungi: Aspergillus terreus GIM3.34 (MIC=18.7 ?g/ml), Aspergillus nidulans (MIC=18.7 ?g/ml), Candida albicans ATCC2002 (MIC=4.7 ?g/ml), Pichia pastoris (MIC=0.3 ?g/ml)."	[Ref.18795096]Non-hemolytic activity at 400 ?g/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	18795096##18620012	PLoS One. 2008 Sep 16;3(9):e3217.##Peptides. 2008 Oct;29(10):1685-1691.	"Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R.##Zhao H, Gan TX, Liu XD, Jin Y, Lee WH, Shen JH, Zhang Y."	Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics.##Identification and characterization of novel reptile cathelicidins from elapid snakes.
DRAMP02474	KFFRKLKKSVKKRAK	15	"cathelicidin-BF15 (Snakes, reptiles, animals)"	B6D434	Not found	Not found	Bungarus fasciatus (Banded krait)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=4.7 ?g/ml), P. aeruginosa IS/DR (MIC=37.5 ?g/ml), P. aeruginosa 08031205 IS/DR (MIC=18.7 ?g/ml), P. aeruginosa 08031014 IS/DR (MIC=75 ?g/ml), Escherichia coli ATCC25922 (MIC=18.7 ?g/ml), E. coli 08A852 IS/DR (MIC=18.7 ?g/ml), E. coli 08A866 IS/DR (MIC=18.7 ?g/ml), E. coli 08031017 IS/DR (MIC=37.5 ?g/ml), E. coli 08040722 IS/DR (MIC=9.4 ?g/ml), K. pneumoniae 08040202 IS/DR (MIC=75 ?g/ml), Salmonella Typhi IS/DR (MIC=1.2 ?g/ml), Saccharibacillus kuerlensis (MIC=4.7 ?g/ml).##Gram-positive bacteria: Bacillus subtilis (MIC=75 ?g/ml), Staphylococcus aureus ATCC2592 (MIC=75 ?g/ml), S. aureus 08A875 IS/DR (MIC=75 ?g/ml), S. aureus 08031002 IS/DR (MIC>100 ?g/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.7 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18795096	PLoS One. 2008 Sep 16;3(9):e3217.	"Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R."	Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics.
DRAMP02478	IKFEPPLPPKKAHKKFWEDDGIYYPPNHNFP	31	"L-amino-acid oxidase (Bm-LAO; LAAO; LAO; Snakes, reptiles, animals)"	B3EWI9	Belongs to the flavin monoamine oxidase family (FIG1 subfamily)	Not found	Bothropoides matogrossensis (Pitviper) (Bothrops neuwiedimatogrossensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic"	Protein level	Not found	Not found	None	"Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity).
Tissue specificity: Expressed by the venom gland."	"Gram-positive bacteria: Bacillus subtilis strain ATCC 6633 (MIC=32 ?M), Enterococcus faecalis strain ATCC 12953 (MIC=32 ?M), Staphylococcus aureus strain ATCC 29213 (MIC=32 ?M), Streptococcus pyogenes strain ATCC 19615 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli strain ATCC 8739 (MIC=4 ?M), Klebsiella pneumoniaee strain ATCC 13885 (MIC=2 ?M), Proteus mirabilis strain ATCC 25933 (MIC=2 ?M), Pseudomonas aeruginosa strain ATCC 15442 (MIC=8 ?M), Salmonella typhimurium strain ATCC 14028 (MIC=8 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22438972	PLoS One. 2012;7(3):e33639.	"Okubo BM, Silva ON, Migliolo L, Gomes DG, Porto WF, Batista CL, Ramos CS, Holanda HH, Dias SC, Franco OL, Moreno SE."	Evaluation of an antimicrobial L-amino acid oxidase and peptide derivatives from Bothropoides mattogrosensis pitviper venom.
DRAMP02520	KRFKKFFKKLKNSVKKRAKKFFKKPRVIGVSIPF	34	"OH-CATH (Snakes, reptiles, animals)"	No entry found	Not found	Not found	Ophiophagus hannah (King cobra) (Naja hannah)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 ?g/ml), E. coli ML-35P (MIC=6 ?g/ml), E. coli clinic strain (MIC=20 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?g/ml), Pseudomonas aeruginosa PA 01 (MIC=2 ?g/ml), Pseudomonas aeruginosa clinic strain (MIC=2 ?g/ml), Enterobacter aerogenes clinic strain (MIC=2 ?g/ml), E. cloacae clinic strain (MIC=1 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18620012	Peptides. 2008 Oct;29(10):1685-1691.	"Zhao H, Gan TX, Liu XD, Jin Y, Lee WH, Shen JH, Zhang Y."	Identification and characterization of novel reptile cathelicidins from elapid snakes.
DRAMP02522	HVINLEESFQEPEYENHLA	19	"L-amino-acid oxidase (LAAO, LAO, Oh-LAAO; Snakes, reptiles, animals)"	"P81383, A8QL50"	Not found	Not found	Ophiophagus hannah (King cobra) (Naja hannah)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: It binds to bacteria and shows antibacterial activities by generating hydrogen peroxide. Binding and antibacterial activities are higher against Gram-positive than against Gram-negative bacteria. May also have an ability to induce hemorrhage, hemolysis, edema, apoptosis.
Tissue specificity: Expressed by the venom gland.
Toxic dose: LD50 is 5 mg/kg by intravenous injection into mice.
Temperature dependence: Exhibits unusual thermal stability. At pH 7.4, the enzyme retains full activity after incubation at 25 degrees Celsius for 30 days. Is stable at alkaline condition and is not inactivated by freezing."	"Gram-negative bacteria: Klebsiella pneumonia (MIC=0.4 ?M), Pseudomonas aeruginosa (MIC=0.2 ?M), Escherichia coli (MIC=0.4 ?M), Escherichia coli ATCC 25922 (MIC=0.8 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=0.006 ?M), S. epidermidis (MIC=0.012 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Bacterial cell	9304806##2619759##2044840##7886693##21059402	Int J Biochem Cell Biol. 1997 Jun;29(6):911-919.##Biochem Int. 1989 Oct;19(4):937-944.##Int J Biochem. 1991;23(3):323-327.##Toxicon. 1994 Nov;32(11):1349-1358.##Comp Biochem Physiol C Toxicol Pharmacol. 2011 M	"Ahn MY, Lee BM, Kim YS.##Tan NH, Saifuddin MN.##Tan NH, Saifuddin MN.##Li ZY, Yu TF, Lian EC.##Lee ML, Tan NH, Fung SY, Sekaran SD."	Characterization and cytotoxicity of L-amino acid oxidase from the venom of king cobra (Ophiophagus hannah).##Isolation and characterization of an unusual form of L-amino acid oxidase from King cobra (Ophiophagus hannah) venom.##Substrate specificity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase.##Purification and characterization of L-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation.##Antibacterial action of a heat-stabl
DRAMP02573	QVYKGGYTRPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS	62	"Penaeidin-3a (Pen-3a; shrimps, Arthropods, animals)"	P81058	Belongs to the penaeidin family	Not found	Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity.
Tissue specificity: Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain.
Developmental stage: Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours.
PTM: C-terminal amidation and contains three disulfide bonds 32-47; 36-54; 48-55."	"Gram-positive bacteria: Aerococcus viridans (MIC=0.3-0.6 ?M), Micrococcus luteus (MIC=1.25-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Enterococcus fecalis (MIC>20 ?M), Saphylococcus aureus (MIC>40 ?M);##Gram-negative bacteria: Escherichia coli 363 (MI=10-20 ?M), Vibrio vulnificus (MIC>20 ?M), Salmonella thyphimurium (MIC>40 ?M), Klebsiella pneumoniae (MIC>40 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Neurospora crassa (MIC=1.25-2.5 ?M), Aspergillus fumigatus (MIC>20 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	pyroglutamic acid	Amidation	"Disulfide bonds between Cys32 and Cys47,Cys36 and Cys54,Cys48 and Cys55. O-glycosylated on Thr8"	L	No cytotoxicity information found	Chitin-binding	9353298##10561573##12842879	J Biol Chem. 1997 Nov 7;272(45):28398-28406.##Eur J Biochem. 1999 Dec;266(2):335-346.##J Biol Chem. 2003 Sep 19;278(38):36859-36867.	"Destoumieux D, Bulet P, Loew D, Van Dorsselaer A, Rodriguez J, Bach¨¨re E.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bach¨¨re E.##Yang Y, Poncet J, Garnier J, Zatylny C, Bach¨¨re E, Aumelas A."	"Penaeidins, a new family of antimicrobial peptides isolated from the shrimp Penaeus vannamei (Decapoda).##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp.##Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide."
DRAMP02574	QVYKGGYARPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYSG	63	"[T8A]-Penaeidin-3a ([T8A]-Pen-3a; shrimps, Arthropods, animals)"	P81058	Belongs to the penaeidin family	Not found	Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (1 helices; 11 residues)	"[T8A]-Pen-3a structure consists of an unconstrained and a constrained part, which roughly match with the proline-rich (1-28 residues) and the cysteine-rich (29-58 residues) domains, respectively. The proline-rich domain does not adopt a constrained structure, whereas the cysteine-rich domain adopts a well-defined structure that consists of a helix (41-50 residues) tightly bound to the upstream (27-40 residues) and the downstream (51-63 "	1UEO resolved by NMR.	"Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity.
PTM: Contains three disulfide bonds."	"Gram-positive bacteria: Aerococcus viridans (MIC=0.4-0.8 ?M), Micrococcus luteus (MIC=0.8-1.6 ?M), Bacillus megaterium (MIC=3.12-6.25 ?M);##Gram-negative bacteria: Escherichia coli 363 (MI=3.12-6.25 ?M), Vibrio vulnificus (MIC>50 ?M), Salmonella thyphimurium (MIC>50 ?M), Klebsiella pneumoniae (MIC>50 ?M).##Fungi: Fusarium oxysporum (MIC=3.12-6.25 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	pyroglutamic acid	Amidation	"Disulfide bonds between Cys32 and Cys47,Cys36 and Cys54,Cys48 and Cys55. O-glycosylated on Thr8"	L	No cytotoxicity information found	Not found	12842879	J Biol Chem. 2003 Sep 19;278(38):36859-36867.	"Yang Y, Poncet J, Garnier J, Zatylny C, Bach¨¨re E, Aumelas A."	"Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide."
DRAMP02584	HSSGYTRPLPKPSRPIFIRPIGCDVCYGIPSSTARLCCFRYGDCCHR	47	"Penaeidin-4a (Pen-4a; shrimps, Arthropods, animals)"	Q95NT0	Belongs to the penaeidin family	Not found	Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity (By similarity).
PTM: Contains three disulfide bonds 23-37; 26-44; 38-45 and C-terminal amidation."	"Gram-positive bacteria: Aerococcus viridans (MIC=1.9-2.92 ?M), Micrococcus luteus (MIC=1.9-2.92 ?M), Bacillus megaterium (MIC>50 ?M), Saphylococcus aureus (MIC>50 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC=22-33 ?M), Vibrio vulnificus (MIC>50 ?M), Salmonella thyphimurium (MIC>50 ?M), Klebsiella pneumoniae (MIC>50 ?M).##Fungi: Fusarium oxysporum (MIC=0.84-1.26 ?M), Botrytis cinerea (MIC=4.38-6.57 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Amidation	"Disulfide bonds between Cys23 and Cys37,Cys26 and Cys44,Cys38 and Cys45."	L	No cytotoxicity information found	Chitin-binding	12242595##15084144	Immunogenetics. 2002 Sep;54(6):442-445.##Biochem J. 2004 Jul 1;381(Pt 1):79-86.	"Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Cuthbertson BJ, Bullesbach EE, Fievet J, Bach¨¨re E, Gross PS."	Diversity of the penaeidin antimicrobial peptides in two shrimp species.##A new class (penaeidin class 4) of antimicrobial peptides from the Atlantic white shrimp (Litopenaeus setiferus) exhibits target specificity and an independent proline-rich-domain function.
DRAMP02586	QRGGFTGPIPRPPPHGRPPLGPICNACYRLSFSDVRICCNFLGKCCHLVK	50	"Penaeidin-2d (Pen-2d; shrimps, Arthropods, animals)"	Q962A9	Belongs to the penaeidin family	Not found	Litopenaeus setiferus (Atlantic white shrimp) (Penaeus setiferus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity).
Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of hemocytes and to a lesser."	"Gram-positive bacteria: Aerococcus viridans (MIC=1.25-2.5 ?M), Micrococcus luteus (MIC=2.5-5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Enterococcus fecalis (MIC>20 ?M), Saphylococcus aureus (MIC>20 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC>40 ?M), Vibrio vulnificus (MIC>20 ?M), Salmonella thyphimurium (MIC>20 ?M), Klebsiella pneumoniae (MIC>20 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Neurospora crassa (MIC=2.5-5 ?M), Aspergillus fumigatus (MIC>20 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	12242595##10561573	Immunogenetics. 2002 Sep;54(6):442-445.##Eur J Biochem. 1999 Dec;266(2):335-346.	"Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bach¨¨re E."	"Diversity of the penaeidin antimicrobial peptides in two shrimp species.##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp."
DRAMP02603	AALRGALRAVARVGKAILPHVAIANPYVRTPYVHNNP	37	"Putative antimicrobial peptide A Northern Europe Heligoland (chordates, animals)"	No entry found	Not found	Not found	Ciona intestinalis 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus megaterium (MIC=0.1 ?M), Bacillus subtilis (MIC=3.1 ?M), Staphylococcus aureus (MIC>25 ?M), Staphylococcus epidermidis (MIC=25 ?M).##Gram-negative bacteria: Escherichia coli K12 D31 (MIC=0.8 ?M), Y. enterocolitica (MIC=3.1 ?M), Klebsiella pneumoniae (MIC>25?M), Pseudomonas aeruginosa (MIC=12.5 ?M), Serratia marcescens(MIC>25 ?M).##Fungi: Candida albicans ATCC 10261 (MIC=6.3 ?M), Candida albicans SC 5314 (MIC=6.3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17658598	Dev Comp Immunol. 2008;32(3):286-298. 	"Fedders H, Leippe M."	A reverse search for antimicrobial peptides in Ciona intestinalis: identification of a gene family expressed in hemocytes and evaluation of activity.
DRAMP02650	APIIRRIPYYPEVESDLRIVDCKRSEGFCQEYCNYLETQVGYCSKKKDACCLH	53	"Sperm associated antigen 11 isoform C (primates, mammals, animals)"	No entry found	Not found	Not found	Macaca mulatta (Rhesus monkey)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=50-100 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15229135	Biol Reprod. 2004 Nov;71(5):1453-1460. 	"Avellar MC, Honda L, Hamil KG, Yenugu S, Grossman G, Petrusz P, French FS, Hall SH."	Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta).
DRAMP02740	YDLSKNCRLRGGICYIGKCPRRFFRSGSCSRGNVCCLRFG	40	"TBD-1 (Turtle beta-defensin 1; Reptiles, animals)"	P86253	Belongs to the beta-defensin family	Not found	Emys orbicularis (European pond turtle)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacteria methicillin-resistant S. aureus ATCC 33591 and L. monocytogenes EGD, the Gram-negative bacterium E. coli ML53p and the yeast C. albicans 820. Has no hemolytic activity towards human erythrocytes.
PTM: Contains three disulfide bonds 7-35; 14-29; 19-36."	"[Ref.19253295]Gram-negative bacterium (LS, HS): Escherichia coli ML35p (MIC=0.65, >20 ?mol/L);##Gram-positive bacteria: (LS, HS): Listeria monocytogenes EGD (MIC=0.65, >20 ?mol/L), Methicillin-resistant Staphylococcus aureus ATCC 33591 (MIC=5.6, >20 ?mol/L).##Yeast: Candida albicans (MIC=5.2, >20 ?mol/L).##NOTE: LS (low salt): 10 mmol/L sodium phosphate buffer (pH 7.4) and HS (high salt): 10 mmol/L sodium-phosphate buffer (pH 7.4), 0.1 mol/L sodium chloride."	[Ref.19253295] It has no hemolytic activity against human erythrocytes up to 25 mmol/L	Cyclic	Free	Free	Disulfide bonds between Cys7 and Cys35; Cys14 and Cys29; Cys19 and Cys36.	L	No cytotoxicity information found	Not found	19253295	Proteomics. 2009 Mar;9(5):1364-1373.	"Stegemann C, Kolobov A Jr, Leonova YF, Knappe D, Shamova O, Ovchinnikova TV, Kokryakov VN, Hoffmann R."	"Isolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles."
DRAMP02768	GLGSVFGRLARILGRVIPKVAKKLGPKVAKVLPKVMKEAIPMAVEMAKSQEEQQPQ	56	"Pilosulin-1 (Myr b I; ants, insects, animals)"	"Q07932, Q9TWC1"	Belongs to the pilosulin family	Not found	Myrmecia banksi (Jack jumper ant) (Australian jumper ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. The synthesized peptide 57-76 shows a potent and broad spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, and also against the fungus C. albicans. Adopts an alpha-helical structure.
Tissue specificity: Expressed by the venom gland.
Allergenic properties: Causes an allergic reaction in human."	"[Ref.9813247]Gram-positive bacteria: Micrococcus luteus (MIC=0.5 ?M), Enterococcus spp.I-11305b (MIC=2 ?M), Enterococcus spp. I-11054 (MIC=2 ?M), Staphylococcus simulans 22 (MIC=2 ?M), S. haemolyticus I-10925 (MIC=2 ?M), S. epidermidis LT1324 (MIC=2 ?M), S. aureuss 5185 (MI=2 ?M), S. aureuss methicillin-sensitive I-11574 (MIC=2 ?M), S. aureuss (MRSA) LT1338 (MIC=3 ?M), S. aureuss (MRSA) LT1334 (MIC=1.5 ?M);##Gram-negative bacteria: Citrobacter freundii I-11090 (MIC=2 ?M), Klebsiella pneumoniae I-10910 (MIC=2 ?M), Escherichia coli I-11276b (MIC=4 ?M), E. coli O-19592 (MIC=2 ?M), Stenotrophomonas maltophilia O-16451 (MIC=2 ?M), S. maltophila I-10717 (MIC=2 ?M), Pseudomonas aeruginosa 4991 (MIC=4 ?M), Pseudomonas aeruginosa I-10968 (MIC=4 ?M);##Fungi: Candida albicans I-11301 (MIC=4 ?M), Candida albicans I-11134 (MIC>4 ?M)."	[Ref.9813247]Complete lysis in the presence of pilosulin 1 was obtained at a concentration of 40 ¦ÌM with evidence of partial lysis visible down to 1.25 ¦ÌM	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	IgE	9813247##9701394##15639237##8866004	Arch Biochem Biophys. 2005 Feb 15;434(2):358-364.##Cytometry. 1998 Aug 1;32(4):268-273.##Arch Biochem Biophys. 2005 Feb 15;434(2):358-364.##Biochem Mol Biol Int. 1996 Aug;39(5):877-885.	"Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.##King MA, Wu QX, Donovan GR, Baldo BA.##Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.##Donovan GR, Street MD, Tetaz T, Smith AI, Alewood D, Alewood P, Sutherland SK, Baldo BA."	Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.##Flow cytometric analysis of cell killing by the jumper ant venom peptide pilosulin 1.##Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.##Expression of jumper ant (Myrmecia pilosula) venom allergens: post-translational processing of allergen gene products.
DRAMP02777	SLQPGAPNFPMPGSQLPTSITSNIEKQGPNTAATINAQHKTDRYDVGATWSKVIRGPGRSKPNWSIGGTYRW	72	"Rhinocerosin (Insects, animals)"	O76145	Belongs to the coleoptericin family	Not found	Oryctes rhinoceros (Coconut rhinoceros beetle)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has strong antibacterial activity against Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus but not against Pseudomonas aeruginosa."	"Gram-positive bacteria: Staphylococcus aureus (MIC=1 ?g/ml), Streptococcus pyogenes (MIC=1 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=1 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9738915	Eur J Biochem. 1998 Aug 1;255(3):734-738.	"Yang J, Yamamoto M, Ishibashi J, Taniai K, Yamakawa M."	"Isolation, cDNA cloning and gene expression of an antibacterial protein from larvae of the coconut rhinoceros beetle, Oryctes rhinoceros."
DRAMP01623	LIGPVLGLVGSALGGLLKKI	20	"Bombinin-H4 (bombinin H isomers; Frogs, amphibians, animals)"	P82284	Belongs to the bombinin family	Not found	Bombina variegata (European frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, hemolytic against mammalian cells, Antifungal"	Protein level	Alpha helix	"The epimerization reaction is incomplete, or, after racemization, the peptides still containing the L-amino acid in position 2 are partly degraded."	None	Function: Have antimicrobial activity. Have some hemolytic activity.	[Ref.8223491] Gram-negative bacterium: Escherichia coli D21 (MIC=4.8 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.3 ?M).	[Ref.8223491] Lethal concentration is 14.6 ?M against human red blood cell.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8223491	EMBO J. 1993; 12:4829-4832.	"Mignogna G, Simmaco M, Kreil G, Barra D.1993"	Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.
DRAMP02779	VTCDLLSFEAKGFAANHSICAAHCLAIGRKGGSCQNGVCVCRN	43	"Defensin-A (Defensin A; Insects, animals)"	P83669	Belongs to the invertebrate defensin family (Type 1 subfamily)	Not found	Anomala cuprea (Cupreous chafer beetle)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Strong activity against the Gram-positive bacteria M.luteus, B.megaterium and S. aureus. Reduced activity against Gram-positive bacterium B.subtilis and weak activity against Gram-negative bacterium X.japonicus.
PTM: Problely contains three disulfide bonds 3-34; 20-39; 24-41."	"Gram-positive bacteria: Bacillus megaterium (MIC=1.2-2.5 ?M), Bacillus subtilis (MIC>40 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Staphylococcus aureus (MIC=2.5-5 ?M).##Gram-negative bacteria: Enterobacter asbriae (MIC>40 ?M), Escherichia coli (MIC>40 ?M), Pseudomonas aeruginosa (MIC>40 ?M), Serratia marcescens (MIC>40 ?M), Xenorhabdus japonicus (MIC>40 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bonds between Cys3 and Cys34; Cys20 and Cys39; Cys24 and Cys41.	L	No cytotoxicity information found	Not found	11719071	Insect Biochem Mol Biol. 2001 Dec;32(1):75-84.	Yamauchi H.	"Two novel insect defensins from larvae of the cupreous chafer, Anomala cuprea: purification, amino acid sequences and antibacterial activity."
DRAMP02780	VTCDLLSFEAKGFAANHSICAAHCLVIGRKGGACQNGVCVCRN	43	"Defensin-B (Defensin B; Insects, animals)"	P83668	Belongs to the invertebrate defensin family (Type 1 subfamily)	Not found	Anomala cuprea (Cupreous chafer beetle)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has antibacterial activity against Gram-positive bacteria and the Gram-negative bacterium X. japonicus.
PTM: Problely contains three disulfide bonds 3-34; 20-39; 24-41."	"Gram-positive bacteria: Bacillus megaterium (MIC=1.2-2.5 ?M), Bacillus subtilis (MIC=20-40 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Staphylococcus aureus (MIC=2.5-5 ?M);##Gram-negative bacterium: X. japonicus (MIC=20-40 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bonds between Cys3 and Cys34; Cys20 and Cys39; Cys24 and Cys41.	L	No cytotoxicity information found	Not found	11719071	Insect Biochem Mol Biol. 2001 Dec;32(1):75-84.	Yamauchi H.	"Two novel insect defensins from larvae of the cupreous chafer, Anomala cuprea: purification, amino acid sequences and antibacterial activity."
DRAMP02802	AREASKSLIGTASCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR	46	"Paneth cell-specific alpha-defensin 1 (DEFA1; horse defensin; houses, mammals, animals"	A6YB85	Not found	DEFA1	Equus caballus (Horse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	2MXQ resolved by NMR.	Function: Membrane permeabilization is at least an essential part of the peptide's mode of action.	"Gram-negative bacteria: Escherichia coli [ATCC 11775 (MBC=0.4 ?M); ATCC 25922 (MBC=0.4 ?M); ATCC 35218 (MBC=0.4 ?M)], E. coli D31 (MBC=0.8 ?M), Pseudomonas aeruginosa ATCC 11440 (MBC=3 ?M);##Gram-positive bacteria: Staphylococcus aureus [ATCC 6538 (MBC=0.8 ?M); ATCC 12600 (MBC=1.5 ?M)], Staphylococcus epidermidis ATCC 14990 (MBC=1.5 ?M), Enterococcus faecalis ATCC 29212 (MBC=6.1 ?M), E. faecalis PEG 205 (wild-type) (MBC=3 ?M), Streptococcus pyogenes ATCC 12344 (MBC=0.8 ?M), Bacillus megaterium ATCC 14581 (MBC=0.2 ?M).##Yeast: Candida albicans ATCC 24433 (MIC=0.8 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bonds between Cys14 and Cys44; Cys16 and Cys32; Cys22 and Cys43.	L	No cytotoxicity information found	Not found	17620056	Biochem J. 2007 Oct 15;407(2):267-276.	"Bruhn O, Regenhard P, Michalek M, Paul S, Gelhaus C, Jung S, Thaller G, Podschun R, Leippe M, Gr?tzinger J, Kalm E."	"A novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function."
DRAMP02809	HPHVCTSYYCSKFCGTAGCTRYGCRNLHRGKLCFCLHCSR	40	"Myticin-B (Myt B; Cys-rich; molluscas, animals)"	P82102	Not found	Not found	Mytilus galloprovincialis (Mediterranean mussel)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Rich	Not found	None	"Function: Bacteriolytic activity against Gram-positive bacteria and Gram-negative bacteria. Also possesses antifungal activity against F. oxysporum.
PTM: contains four disulfide bonds."	"Gram-positive bacteria: Micrococcus luteus (MBC=1-2 ?M), Bacillus megaterium (MBC=1-2 ?M), Aerococcus viridans (MBC=2-4 ?M).##Gram-negative bacteria: Escherichia coli D31 (MBC=20-10 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	contains four disulfide bonds.	L	No cytotoxicity information found	Not found	10491159	Eur J Biochem. 1999 Oct 1;265(1):71-78.	"Mitta G, Hubert F, No?l T, Roch P."	"Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis."
DRAMP02811	GFGCPNNYQCHRHCKSIPGRCGGYCGGWHRLRCTCYRC	38	"Defensin MGD-1 (molluscas, animals)"	"P80571, Q9Y0B0"	Not found	FH3	Mytilus galloprovincialis (Mediterranean mussel)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	"The three-dimensional solution structure of MGD-1 has been established using (1)H NMR and mainly consists of a helical part (Asn7-Ser16) and two antiparallel beta-strands (Arg20-Cys25 and Cys33-Arg37), together giving rise to the common cystine-stabilized alpha-beta motif frequently observed in scorpion toxins. In MGD-1, the cystine-stabilized alpha-beta motif is stabilized by four disulfide bonds (Cys4-Cys25, Cys10-Cys33, Cys14-Cys35, "	1FJN resolved by NMR.	"Function: Active against both Gram-positive and Gram-negative bacteria but is not cytotoxic towards human erythrocytes or protozoa.
Transgenic plants: expression of this peptide in tobacco improves resistance to pathogens.
PTM: Contains four disulfide bonds 4-25; 10-33; 14-35; 21-38."	"Gram-positive bacteria: Micrococcus luteus (MIC=0.4 ?M)&(MBC=1.5 ?M), Bacillus megaterium (MIC=0.8 ?M)&(MBC=1.5 ?M), Staphylococcus aureus (MIC=0.6 ?M)&(MBC=1.2 ?M), Staphylococcus epidermidis (MIC=3.1 ?M)&(MBC=6.2 ?M), Enterococcus fecalis (MIC=0.6 ?M)&(MBC=1.2 ?M), Aerococcus viridans (MIC=0.4 ?M)&(MBC=1.5 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC=1.2 ?M)&(MBC=1.2 ?M), E. coli 363 (MIC=1.2 ?M)&(MBC=1.2 ?M), Salmonella newport (MIC>100 ?M)&(MBC>100 ?M), Vibrio alginolyticus (MIC=50 ?M)&(MBC>100 ?M), Vibrio harveyi (MIC=50 ?M)&(MBC=100 ?M), Vibrio metshnikovii (MIC>100 ?M)&(MBC>100 ?M).##NOTE: MIC=minimal inhibitory concentration; MBC = minimal bactericidal concentration."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bond between Cys4 and Cys25, Cys10 and Cys33, Cys14 and Cys35,Cys21 and Cys38."	L	No cytotoxicity information found	Not found	10564642##8925841##11087396	J. Cell Sci. 1999;112:4233-4242.##Eur. J. Biochem. 1996;240:302-306.##Biochemistry 2000 Nov 28;39(47):14436-47.	"Mitta G, Vandenbulcke F, Hubert F, Roch P.##Hubert F, Noeel T, Roch P.##Yang YS, Mitta G, Chavanieu A, Calas B, Sanchez JF, Roch P, Aumelas A."	Mussel defensins are synthesised and processed in granulocytes then released into the plasma after bacterial challenge.##A member of the arthropod defensin family from edible Mediterranean mussels (Mytilus galloprovincialis).##Solution structure and activity of the synthetic four-disulfide bond Mediterranean mussel defensin (MGD-1).
DRAMP02817	VDKGSYLPRPTPPRPIYNRN	20	Pyrrhocoricin	"P37362, P80307"	Belongs to the drosocin family	Not found	Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	Not found	4EZN resolved by X-ray.	"Function: Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis."	"Gram-positive bacteria: Micrococcus luteus (MIC>80 ?M in L.B, P.B), Bacillus megaterium (MIC>80 ?M in L.B, P.B);##Gram-negative bacteria: Escherichia coliD22 (MIC=0.3 ?M in L.B, P.B), A.tumefaciens (MIC=1.25 ?M in LB and 3 ?M in PB), Salmonella typhimurium (MIC=5 ?M in L.B and 10 ?M in P.B)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10076062##8002963##23562829	Biochim Biophys Acta. 1999 Feb 2;1426(3):459-467.##Biochem J. 1994 Jun 1;300 (Pt 2):567-575.##J Mol Biol. 2013 Jul 24;425(14):2463-2479.	"Hoffmann R, Bulet P, Urge L, Otv?s L Jr.##Cociancich S, Dupont A, Hegy G, Lanot R, Holder F, Hetru C, Hoffmann JA, Bulet P.##Zahn M, Berthold N, Kieslich B, Knappe D, Hoffmann R, Str?ter N."	"Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects.##Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.##Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK."
DRAMP01381	GLFTLIKGAAKLIGKTVPKKQARLGMNLWLVKLPTNVKT	39	"Odorranain-K1 (OdK1; Frogs, amphibians, animals)"	A6MBN8	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Odorranain-K1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 ¦Ìg/ml), Bacillus subtilis (MIC=1.10 ¦Ìg/ml).##Yeast: Candida albicans (MIC=1.10 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01383	ATAWDFGPHGLLPIRPIRIRPLCGKDKS	28	"Odorranain-M1 (OdM1; Frogs, amphibians, animals)"	A6MBP6	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Odorranain-M1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=9.37 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 ¦Ìg/ml), Bacillus subtilis (MIC=75 ¦Ìg/ml).##Yeast: Candida albicans (MIC=18.75 ¦Ìg/ml). "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP02841	RQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIK	34	Lumbricin I(6¨C34)	O96447	Not found	Not found	Synthetic construct (derived from residues 6¨C34 of lumbricin I)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Lumbricin I(6-34) has marginally stronger antimicrobial activities than lumbricin I. Has weak hemolytic activity  when tested against human erythrocytes.	"[Ref.9784609]Gram-positive bacteria: Bacillus subtilis ATCC 62037 (MIC=8 ?g/ml), Staphylococcus aureus ATCC 15752 (MIC=12 ?g/ml), Streptococcus mutans ATCC 25175 (MIC=20 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 27325 (MIC=8 ?g/ml), Pseudomonas putidaATCC 17426 (MIC=12 ?g/ml), Serratia sp. ATCC 21074 (MIC=12 ?g/ml).##Fungi: Candida albicans ATCC 10231 (MIC=12 ?g/ml), Cryptococcus neoformance ATCC 34881 (MIC=16 ?g/ml), Saccharomyces cerevisiae ATCC 44774 (MIC=8 ?g/ml).##NOTE: Minimal inhibitory concentrations were determined by incubating approximately 104¨C105 CFU/ml of cells with serial dilutions of each peptide in a 96-well microtiter plate.."	"[Ref.9784609]0.03% hemolytic activity at 5 ¦Ìg/ml, 0.07% hemolytic activity at 10 ¦Ìg/ml, 0.13% hemolytic activity at 25 ¦Ìg/ml, 0.17% hemolytic activity at 50 ¦Ìg/ml, 0.21% hemolytic activity at 100 ¦Ìg/ml against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9784609	Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76.	"Cho JH, Park CB, Yoon YG, Kim SC."	"Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization."
DRAMP02843	ILKKWPWWPWRRKX	14	"chain a, Structure Of An Indolicidin Peptide Derivative With"	No entry found	Not found	Not found	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Non helix or strand structure	Not found	1QXQ resolved by NMR.	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=8 ?g/ml), Pseudomonas aeruginosa (MIC=16 ?g/ml), Salmonella typhimurium (MIC=64 ?g/ml), S. typhimurium defensin sensitive (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) (MIC=16 ?g/ml), S. epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11123901	Biochemistry. 2000 Dec 26;39(51):15765-15774.	"Rozek A, Friedrich CL, Hancock RE."	Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.
DRAMP02845	ICLKKWPWWPWRRCKX	16	"CP-11 (cathelicidin; mammals, animals)"	No entry found	Not found	Not found	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Non helix or strand structure	Not found	1QX9 resolved by NMR.	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=16 ?g/ml), Pseudomonas aeruginosa (MIC=64 ?g/ml), Salmonella typhimurium(MIC=64 ?g/ml), S. typhimurium defensin sensitive (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) (MIC=16 ?g/ml), S. epidermidis(MIC=8 ?g/ml), Enterococcus faecalis (MIC=64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11123901##14640680 	Biochemistry. 2000 Dec 26;39(51):15765-15774.##Biochemistry. 2003 Dec 9;42(48):14130-14138.	"Rozek A, Friedrich CL, Hancock RE.##Rozek, A.; Powers, JP.; Friedrich, CL.; Hancock, RE. "	Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.##Structure-based design of an indolicidin peptide analogue with increased protease stability. 
DRAMP02849	RFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLRFP	42	"Bactenecin 5 (mammals, animals)"	No entry found	Not found	Not found	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Salmonella typhimurium (MIC=2-10 ?M), Klebsiella pneumoniae, Escherichia coli."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2229048	J Biol Chem. 1990 Nov 5;265(31):18871-18874.	"Frank RW, Gennaro R, Schneider K, Przybylski M, Romeo D."	Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils.
DRAMP02851	RLCRIVVIRVCR	12	"Cathelicidin-1 (Bactenecin-1, Bac1; Cyclic dodecapeptide; mammals, animals)"	"P22226, A5PJA3, Q24JY5"	Belongs to the cathelicidin family	CATHL1	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Three disulfide bonds.	None	"Function: Potent microbicidal activity; active against S.aureus and E.coli.
Tissue specificity: Large granules of neutrophils.
PTM: Contains three disulfide bonds."	Gram-positive bacterium: Staphylococcus aureus (MIC=1-8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=8-25 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys11.	L	No cytotoxicity information found	Not found	3290210	J Biol Chem. 1988 Jul 15;263(20):9573-9575.	"Romeo D, Skerlavaj B, Bolognesi M, Gennaro R."	Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils.
DRAMP02854	GGLRSLGRKILRAWKKYGPIIVPIIRIG	28	Cathelicidin-5 (Antibacterial peptide BMAP-28; Myeloid antib	"P54229, A5PJ96, B9UKL6"	Belongs to the cathelicidin family	CATHL5	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi.
PTM: Contains two disulfide bonds. (By similarity)"	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), E. coli ML35 (MIC=2 ?M), E. coli D21 (MIC=0.5 ?M), Salmonella typhimurium ATCC 14028 (MIC=1 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Staphylococcus aureus (MRSA) (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=8 ?M), Cryptococcus neoformans (MIC=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8910461##8706679	J Biol Chem. 1996 Nov 8;271(45):28375-28381.##Eur J Biochem. 1996 Jun 15;238(3):769-776.	"Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.##Storici P, Tossi A, Lenarcic B, Romeo D."	"Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.##Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides."
DRAMP02855	GRFKRFRKKFKKLFKKLSPVIPLLHLG	27	"Cathelicidin-6 (Antibacterial peptide BMAP-27, Myeloid antib"	"P54228, B9UKM5"	Belongs to the cathelicidin family	CATHL6	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (2 helices; 19 residues)	Not found	2KET resolved by NMR.	"Function: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi.
PTM: Contains two disulfide bonds. (By similarity)"	"Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1 ?g/ml), E. coli ML35 (MIC=1 ?g/ml), E. coli D21 (MIC=0.25 ?g/ml), Salmonella typhimurium ATCC 14028 (MIC=1 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?g/ml), Serratia marcescens ATCC 8100 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?g/ml), Staphylococcus aureus Cowan 1 (MIC=2 ?g/ml), Staphylococcus aureus (MRSA) (MIC=4 ?g/ml), S. epidermidis ATCC 12228 (MIC=1 ?g/ml), Bacillus megaterium Bm11 (MIC=2 ?g/ml).##Fungi: Candida albicans (MIC=8 ?g/ml), Cryptococcus neoformans (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8910461##19136450##PubMed ID is not available	J. Biol. Chem. 1996;271:28375-28381.##J. Hered. 2009;100:241-245.##To be Published	"Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.##Gillenwaters EN, Seabury CM, Elliott JS, Womack JE.##Yang S, Jung H, Kim J."	Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.##Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.##solution structure of BMAP-27.
DRAMP02858	DFASCHTNGGICLPNRCPGHMIQIGICFRPRVKCCRSW	38	"Bovine Beta-defensin 1 (bBD-1; BNBD-1; BNDB-1; mammals, animals)"	P46159 	Belongs to the beta-defensin family	DEFB1	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Bridge 	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 but not against S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)"	Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16777238	Vet Immunol Immunopathol. 2006 Sep 15;113(1-2):181-190. 	"Aono S, Li C, Zhang G, Kemppainen RJ, Gard J, Lu W, Hu X, Schwartz DD, Morrison EE, Dykstra C, Shi J."	Molecular and functional characterization of bovine beta-defensin-1.
DRAMP02859	VRNHVTCRINRGFCVPIRCPGRTRQIGTCFGPRIKCCRSW	40	"Bovine Beta-defensin 2 (bBD-2; BNBD-2; BNDB-2; mammals, animals)"	P46160	Belongs to the beta-defensin family	DEFB2	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge 	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 7-36; 14-29; 19-37. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635	J Biol Chem. 1993 Mar 25;268(9):6641-6648.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS."	"Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."
DRAMP02860	EGVRNHVTCRINRGFCVPIRCPGRTRQIGTCFGPRIKCCRSW	42	"Bovine Beta-defensin 3 (bBD-3; BNBD-3; BNDB-3; mammals, animals)"	P46161	Belongs to the beta-defensin family	DEFB3	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge 	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635##9488394	J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Infect Immun. 1998 Mar;66(3):1045-1056.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL."	"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection."
DRAMP02861	QRVRNPQSCRWNMGVCIPFLCRVGMRQIGTCFGPRVPCCRR	41	"Bovine Beta-defensin 4 (bBD-4; BNBD-4; BNDB-4; mammals, animals)"	P46162	Belongs to the beta-defensin family	DEFB4	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 520A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available##8454635	Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.##J Biol Chem. 1993 Mar 25;268(9):6641-6648.	"Yount N.Y, Yuan J, Diamond G, Tarver A, McGuire P.A, McCullough C, Cullor J.S, Bevins C.L, Selsted M.E.##Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS."	"Molecular cloning and expression of an antimicrobial beta-defensin from bovine neutrophils. Characterization of BNBD-4 cDNA and genomic sequences and localization of the peptide to large granules of mature neutrophils.##Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."
DRAMP02862	QVVRNPQSCRWNMGVCIPISCPGNMRQIGTCFGPRVPCCRRW	42	"Bovine Beta-defensin 5 (bBD-5; BNBD-5; BNDB-5; mammals, animals)"	"P46163, O97533"	Belongs to the beta-defensin family	DEFB5	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 but not against S. aureus 502A.
Tissue specificity: Neutrophilic granules. Alveolar macrophages.
PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)"	Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635	J Biol Chem. 1993 Mar 25;268(9):6641-6648.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS."	"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."
DRAMP02863	QGVRNHVTCRIYGGFCVPIRCPGRTRQIGTCFGRPVKCCRRW	42	"Bovine Beta-defensin 6 (bBD-6; BNBD-6; BNDB-6; mammals, animals)"	P46164	Belongs to the beta-defensin family	DEFB6	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635	J Biol Chem. 1993 Mar 25;268(9):6641-6648.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS."	"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."
DRAMP02865	VRNFVTCRINRGFCVPIRCPGHRRQIGTCLGPQIKCCR	38	"Bovine Beta-defensin 8 (bBD-8; BNBD-8; BNDB-8; mammals, animals)"	P46166	Belongs to the beta-defensin family	DEFB8	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 7-36; 14-29; 19-37. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635	J Biol Chem. 1993 Mar 25;268(9):6641-6648.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS."	"Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."
DRAMP02866	QGVRNFVTCRINRGFCVPIRCPGHRRQIGTCLAPQIKCCR	40	"Bovine Beta-defensin 9 (bBD-9; BNBD-9; BNDB-9; mammals, animals)"	"P46167, O18814"	Belongs to the beta-defensin family	DEFB9	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-301 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635##9488394	J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Infect Immun. 1998 Mar;66(3):1045-1056.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL."	"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection."
DRAMP02867	QGVRSYLSCWGNRGICLLNRCPGRMRQIGTCLAPRVKCCR	40	"Bovine Beta-defensin 10 (bBD-10; BNBD-10; BNDB-10; mammals, animals)"	"P46168, Q5W5G8"	Belongs to the beta-defensin family	DEFB10	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635##15520886	J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Mamm Genome. 2004 Oct;15(10):834-842.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Roosen S, Exner K, Paul S, Schr?der JM, Kalm E, Looft C."	"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue."
DRAMP02868	GPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW	38	"Bovine Beta-defensin 11 (bBD-11; BNBD-11; BNDB-11; mammals, animals)"	"P46169, Q5W5G7"	Belongs to the beta-defensin family	DEFB11	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635##15520886	J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Mamm Genome. 2004 Oct;15(10):834-842.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Roosen S, Exner K, Paul S, Schr?der JM, Kalm E, Looft C."	"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue."
DRAMP02869	GPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW	38	"Bovine Beta-defensin 12 (bBD-12; BNBD-12; BNDB-12; mammals, animals)"	P46170	Belongs to the beta-defensin family	DEFB12	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Beta strand	Not found	1BNB resolved by NMR.	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635##8454636	J Biol Chem. 1993 Mar 25;268(9):6641-6648.##J Biol Chem. 1993 Mar 25;268(9):6649-6653.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tang YQ, Selsted ME."	"Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils."
DRAMP02870	SGISGPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW	42	"Bovine Beta-defensin 13 (bBD-13; BNBD-13; BNDB-13; mammals, animals)"	P46171	Belongs to the beta-defensin family	DEFB13	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=10-300 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635	J Biol Chem. 1993 Mar 25;268(9):6641-6648.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS."	"Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."
DRAMP02872	GRFKRFRKKFKKLFKKLS	18	"Myeloid antimicrobial peptide BMAP-27 (1-18) (mammals, animals)"	No entry found	Not found	Not found	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), Escherichia coli ML35 (MIC=4 ?M), Escherichia coli D21 (MIC=4 ?M), Salmonella typhimurium ATCC 14028 (MIC=4 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Staphylococcus aureus (MRSA) (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=16 ?M), Cryptococcus neoformans (MIC=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8910461	J Biol Chem. 1996 Nov 8;271(45):28375-28381.	"Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M."	Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.
DRAMP02873	GGLRSLGRKILRAWKKYG	18	"Myeloid antimicrobial peptide BMAP-28 (1-18) (mammals, animals)"	No entry found	Not found	Not found	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=0.5 ?M), Escherichia coli D21 (MIC=0.5 ?M), Salmonella typhimurium ATCC14028 (MIC=2 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Staphylococcus aureus (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=16 ?M), Cryptococcus neoformans (MIC=2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8910461	J Biol Chem. 1996 Nov 8;271(45):28375-28381.	"Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M."	Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.
DRAMP02877	GGLRSLGRKILRAWKKYGPQATPATRQ	27	"mBMAP28 (mammals, animals)"	No entry found	Not found	Not found	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=0.5 ?M), Salmonella typhimurium ATCC 14028 (MIC=1 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.5 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=2 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=8 ?M), Cryptococcus neoformans (MIC=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8910461	J. Biol. Chem. 1996; 271:28375-28381	"Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.1996"	Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.
DRAMP02878	NPVSCVRNKGICVPIRCPGSMKQIGTCVGRAVKCCRKK	38	"Tracheal antimicrobial peptide (TAP; mammals, animals)"	"P25068, O97532"	Belongs to the beta-defensin family (LAP/TAP subfamily)	Not found	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity in vitro. In addition, the peptide is active against Candida albicans, indicating a broad spectrum of activity.
Tissue specificity: Tracheal epithelium.
PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)"	"Gram-negative bacteria: Escherichia coli D31 (MIC=12-25 ?g/ml), Klebsiella pneumoniae 13883 (MIC=12-25 ?g/ml), Pseudomonas aeruginosa 27853 (MIC=25-50 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=25-50 ?g/ml).##Fungi: Candida ablicans (MIC=6-12 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2023943##8506305	Proc Natl Acad Sci U S A. 1991 May 1;88(9):3952-3956.##Proc Natl Acad Sci U S A. 1993 May 15;90(10):4596-4600. 	"Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL.##Diamond G, Jones DE, Bevins CL."	"Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.##Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene."
DRAMP02903	ILGPILGLVSNALGGLL	17	Bombin H7	No entry found	Not found	Not found	Bombina orientalis 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Bacillus megaterium Bm11 (MIC=3.3 ?M);##Gram-negative bacterium: Escherichia coli D22 (MIC=3.7 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10333736	Biopolymers. 1998;47(6):435-450.	"Simmaco M, Mignogna G, Barra D."	Antimicrobial peptides from amphibian skin: what do they tell us?
DRAMP02910	LRRIIRKIIHIIKK	14	"Ovispirin-2 (OV-2; mammals, animals)"	No entry found	Not found	Not found	Ovis aries (Sheep)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=0.03-16 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11557478	Antimicrob Agents Chemother. 2001 Oct;45(10):2838-2844.	"Saiman L, Tabibi S, Starner TD, San Gabriel P, Winokur PL, Jia HP, McCray PB Jr, Tack BF."	Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis.
DRAMP02911	IRRIIRKIIHIIKK	14	"Ovispirin-3 (OV-3; mammals, animals)"	No entry found	Not found	Not found	Ovis aries (Sheep)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=1-8 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11557478	Antimicrob Agents Chemother. 2001 Oct;45(10):2838-2844.	"Saiman L, Tabibi S, Starner TD, San Gabriel P, Winokur PL, Jia HP, McCray PB Jr, Tack BF."	Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis.
DRAMP02922	KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPK	34	"Canine beta-defensin (dogs, mammals, animals)"	No entry found	Not found	Not found	Canis lupus familiaris (Dog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli 25922 (MIC=20 ?g/ml), Escherichia coli 700336 (MIC=50 ?g/ml);##Gram-positive bacteria: Klebsiella pneumoniae 10031 (MIC=20 ?g/ml), Listeria monocytogenes 19115 (MIC=10 ?g/ml), Staphylococcus aureus 10832 (MIC=100 ?g/ml), N. gonorrhoeae 10150 (MIC=50 ?g/ml).##Fungi: Candida albicans 14053 (MIC=50 ?g/ml), Candida albicans 11006 (MIC=5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15845463	Infect Immun. 2005 May;73(5):2611-2620.	"Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T."	Molecular cloning and characterization of three beta-defensins from canine testes.
DRAMP02923	KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPKFQPNMLQR	42	"cBD-1 (Canine beta-defensin 1; dogs, mammals, animals)"	No entry found	Not found	Not found	Canis Lupis (Dog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Listeria monocytogenes(MIC=6 m?g/ml), Staphylococcus aureus (MIC=100 m?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=20-25 m?g/ml), Klebsiella pneumoniae (MIC=20 m?g/ml), Neisseria gonorrhoeae (MIC=50 m?g/ml).##Yeast: Candida albicans (MIC=5-50 m?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15845463	Infect Immun. 2005 May;73(5):2611-2620.	"Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T."	Molecular cloning and characterization of three beta-defensins from canine testes.
DRAMP02925	RLKELITTGGQKIGEKIRRIGQRIKDFFKNLQPREEKS	38	"Cathelicidin (dogs, mammals, animals)"	No entry found	Not found	Not found	Canis lupus familiaris (Dog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=1.25 ?M), Klebsiella pneumoniae (MIC=1.25 ?M), Salmonella serotype Typhimurium (MIC=1.25 ?M), Pseudomonas aeruginosa (MIC=1.25 ?M), Proteus mirabilis (MIC=1.25 ?M), Salmonella serotype Enteritidis (MIC=0.5 ?M), Neisseria gonorrhoeae (MIC=0.06 ?M).##Gram-positive bacteria: Listeria monocytogenes (MIC=0.5 ?M), Staphylococcus aureus (MIC=50 ?M).##Fungi: Candida albicans (MIC=12.5-50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17462733	Dev Comp Immunol. 2007;31(12):1278-1296.	"Sang Y, Teresa Ortega M, Rune K, Xiau W, Zhang G, Soulages JL, Lushington GH, Fang J, Williams TD, Blecha F, Melgarejo T."	"Canine cathelicidin (K9CATH): gene cloning, expression, and biochemical activity of a novel pro-myeloid antimicrobial peptide."
DRAMP02931	SPRVSRRYGRPFGGRPFVGGQFGGRPGCVCIRSPCPCANYG	41	"Arasin-likeSp (crabs, Arthropods, animals)"	No entry found	Not found	Not found	Scylla paramamosain (Mud crab)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus haemolyticus (MIC=6.25-12.5 ?M), Aerococcus viridans (MIC=0.19-0.39 ?M), Micrococcus luteus (MIC=0.39-0.78 ?M), Bacillus subtilis (MIC=6.25-12.5 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC>50 ?M), Aeromonas hydrophila (MIC>50 ?M), V. harveyi (MIC=0.78-1.56 ?M), Vibrio anguillarum (MIC=3.125-6.25 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21220028	Fish Shellfish Immunol. 2011 Feb;30(2):706-712.	"Imjongjirak C, Amparyup P, Tassanakajon A."	"Two novel antimicrobial peptides, arasin-likeSp and GRPSp, from the mud crab Scylla paramamosain, exhibit the activity against some crustacean pathogenic bacteria."
DRAMP02933	RRWCFRVCYRGFCYRKCR	18	"Polyphemusin-1 (PM1; crabs, Arthropods, animals)"	P14215	Belongs to the tachyplesin/polyphemusin family	Not found	Limulus polyphemus (Atlantic horseshoe crab)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand (2 strands; 4 residues)	"The solution structure of polyphemusin I is determined using (1)H-NMR spectroscopy. Polyphemusin I is found to be an amphipathic, beta-hairpin connected by a type I' beta-turn."	1RKK resolved by NMR.	"Function: PM1 showes high antimicrobial activity against the Gram-negative, Gram-positive and fungal specimens tested.
Tissue specificity: Hemocytes.
PTM: Contains two disulfide bonds 4-17; 8-13 and C-terminal amidation."	"Gram-negative bacteria: Escherichia coli UB1005 (MIC=0.5 ?g/ml), E. coli DC2 (MIC=1 ?g/ml), Salmonella typhimurium (defensin-sensitive) (MIC=0.25 ?g/ml), S. typhimurium (MIC=1 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), P. aeruginosa Z61 (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=1 ?g/ml), Enterococcus faecalis (MIC=1 ?g/ml).##Yeasy: Candida albicans (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Amidation	"Disulfide bond between Cys4 and Cys17,Cys8 and Cys13."	L	No cytotoxicity information found	Not found	2514185##15134657	J Biochem. 1989 Oct;106(4):663-668.##Biochim Biophys Acta. 2004 May 6;1698(2):239-250.	"Miyata T, Tokunaga F, Yonega T, Yoshikawa K, Iwanaga S, Niwa M, Takao T, Shimonishi Y.##Powers JP, Rozek A, Hancock RE."	"Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity.##Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I."
DRAMP02934	RRWSFRVSYRGFSYRKSR	18	PM1-S (linear derivative of PM1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	No secondary structure (CD)	"The CD spectra of PM1-S indicates that, in all environments (phosphate buffer, TFE, and liposomes), the peptide displays no observable patterns that could be related to structural features. This indicates that PM1-S is a flexible molecule with no favoured conformation."	None	Function: PM1-S remaines active against Gram-negative bacteria but displayed poor activity to both Gram-positive and fungal microorganisms.	"Gram-negative bacteria: Escherichia coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=4 ?g/ml), Salmonella typhimurium (defensin-sensitive) (MIC=2 ?g/ml), S. typhimurium (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), P. aeruginosa Z61 (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=32 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeasy: Candida albicans (MIC=64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15134657	Biochim Biophys Acta. 2004 May 6;1698(2):239-250.	"Powers JP, Rozek A, Hancock RE."	Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I.
DRAMP02950	YVDREINLFDHYCIISRSPHISRWELKWQATVTCPGWTPVKGKVRGYSNPLSAEREATRDFVQRIVQRGLVTRDEASEWL	80	"PtALF5 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 5; crabs, Arthropods, ani"	No entry found	Not found	Not found	Portunus trituberculatus (Swimming Crab)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Contains a signal peptide and an LPS-binding Domain: (CIISRSPHISRWELKWQATVTC) and two conserved cysteine residues which can form a disulfide bridge. PtALF5 transcript in hemocytes showes a clear time-dependent response expression pattern with obvious decrease at 6 h and significant increase at 24 h. The recombinant PtALF5 has antimicrobial activity against Gram-negative bacteria Vibrio alginolyticus and Pseudomonas aeruginosa.	"Gram-negative bacteria: Vibrio alginolyticus (MIC=3.89-7.78 ?M), Edwardsiella tarda (MIC=7.78-15.54 ?M), Pseudomonas aeruginosa (MIC=15.54-31.08 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	21362485##22516300	Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2012 Jul;33(1):85-91.	"Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Li Q, Wang S."	"Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##Molecular cloning, expression pattern and antimicrobial activity of a new isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus."
DRAMP02951	MARVSLLLIVLSIALVAPSQGFLKDLLFGEAKTALLEDGTTEILDHVCNFRVMPRLRSWELYFRGDVWCPGWTVIKGESL	80	"PtALF6 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 6; crabs, Arthropods, ani"	No entry found	Not found	Not found	Portunus trituberculatus (Swimming Crab)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Contains a signal peptide and an LPS-binding Domain: (CNFPVMPRLRSWELYFRGDVWC) and two conserved cysteine residues which can form a disulfide bridge.	"Gram-negative bacteria: Vibrio alginolyticus L59 (MIC=1.17-2.33 ?M), Pseudomonas aeruginosa P25 (MIC=9.32-18.64 ?M);##Gram-positive bacteria: Micrococcus luteus M2 (MIC=9.32-18.64 ?M), Staphylococcus aureus S7 (MIC=9.32-18.64 ?M).##Fungi: Pichia pastoris GS115 (MIC>74.57 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	21362485##23257203	Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2013 Feb;34(2):463-470.	"Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Shi G."	Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##A newly identified anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus with broad spectrum antimicrobial activity.
DRAMP02952	MRKGVVTGLFVALVVMCLYLPQPCEAQYEALTAAILTKLSKMWHSDTLNFLGHTCHVSRTPTVKRFKLYWKGKFWCPGWA	80	"PtALF7 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 7; crabs, Arthropods, ani"	No entry found	Not found	Not found	Portunus trituberculatus (Swimming Crab)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Contains a signal peptide and an LPS-binding Domain: (CHVSRTPTVKRFKLYWKGKFWC) and two conserved cysteine residues which can form a disulfide bridge.	"Gram-negative bacteria: Vibrio alginolyticus (MIC=0.51-1.02 ?M), Edwardsiella tarda (MIC=2.04-4.07 ?M), Pseudomonas aeruginosa (MIC=1.02-2.04 ?M);##Gram-positive bacteria: Micrococcus luteus (MIC=32.59-65.19 ?M), Staphylococcus aureus (MIC=8.15-16.30 ?M).##Fungi: Pichia pastoris (MIC>130.37 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	21362485##23261507	Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2013 Feb;34(2):652-659.	"Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Shi G, Wang C."	"Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##Molecular cloning, genomic structure and antimicrobial activity of PtALF7, a unique isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus."
DRAMP02953	SRWPSPGRPRPFPGRPKPIFRPRPCNCYAPPCPCDRW	37	"Arasin-1 (Pro-rich, Arg-rich; crabs, Arthropods, animals)"	A6XMY0	Not found	Not found	Hyas araneus (Great spider crab) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Corynebacterium glutamicum (MIC=0.8 ?M), Listonella anguillarum (MIC=6.3 ?M);##Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bond between Cys25 and Cys34,Cys27 and Cys32."	L	No cytotoxicity information found	Not found	17658600	Dev Comp Immunol. 2008;32(3):275-285.	"Stensvag K, Haug T, Sperstad S.V, Rekdal O, Indrevoll B, Styrvold O.B."	"Arasin 1, a proline-arginine-rich antimicrobial peptide isolated from the spider crab, Hyas araneus."
DRAMP02956	SHQDCYEALHKCMASHSKPFSCSMKFHMCLQQQ	33	Dolabellanin B2	P83376	Not found	Not found	Dolabella auricularia (Sea hare)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also possesses antifungal activity.
PTM: Contains two disulfide bonds. Up to two of the methionines may be oxidized to methionine sulfoxides."	"Gram-positive bacteria: Bacillus subtilis RIMD0225014 (MIC=2.5 ?g/ml), Staphylococcus aureus IID1677 (MRSA) (MIC=20.0 ?g/ml), Listeria monocytogenes VIU206 (MIC=40.0 ?g/ml).##Gram-negative bacteria: Haemophilus influenzae IID983 (MIC=5.0 ?g/ml), V. vulnificus RIMD2219009 (MIC=5.0 ?g/ml), Escherichia coli JM109 (MIC=20.0 ?g/ml), E. coli DH5?¡À (MIC=40.0 ?g/ml).##Fungi: Candida albicans ATCC36232, Candida tropicalis TIMM0313, S. pombe IFO1628, Saccharomyces cerevisiae A581A."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Contains two disulfide bonds. Up to two of the methionines may be oxidized to methionine sulfoxides.	L	No cytotoxicity information found	Not found	12590964	Dev. Comp. Immunol. 2003;27:305-311.	"Iijima R, Kisugi J, Yamazaki M."	A novel antimicrobial peptide from the sea hare Dolabella auricularia.
DRAMP02959	RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP	39	"Antibacterial protein PR-39 (pigs, mammals, animals)"	"P80054, Q9TR84"	Belongs to the cathelicidin family	PR39	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Rich	Not found	None	"Tissue specificity: Small intestine and bone marrow.
PTM: Proline amide at P39."	"Gram-negative bacteria: Escherichia coli K12 D21 (MIC=0.3 ?M), Escherichia coli Bd2221175 (MIC=0.3 ?M), Salmonella typhimurium LT2 (MIC=1?M), Proteus vulgaris Pvll (MIC=300 ?M), Pseudomonas aeruginosa OT97 (MIC=200 ?M), Acinetobacter calcoaceticus Acl 1 (MIC=3 ?M).##Gram-positive bacteria: Bacillus megaterium (MIC=0.3 ?M), Bacillus subtilis (MIC=15 ?M), Staphylococcus aureus (MIC=200 ?M), Streptococcus pyogenes (MIC=2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1765098##7624374	Eur J Biochem. 1991 Dec 18;202(3):849-854.##Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7085-7089.	"Agerberth B, Lee JY, Bergman T, Carlquist M, Boman HG, Mutt V, J?rnvall H.##Gudmundsson GH, Magnusson KP, Chowdhary BP, Johansson M, Andersson L, Boman HG."	"Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides.##Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39."
DRAMP02960	RIIDLLWRVRRPQKPKFVTVWVR	23	"Antibacterial peptide PMAP-23 (Myeloid antibacterial peptide 23; pigs, mammals, animals)"	P49930	Belongs to the cathelicidin family	PMAP23	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Alpha helix 	Not found	None	"Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes.
PTM: Contains two disulfide bonds (By similarity)."	"Gram-negative bacteria: Escherichia coli ML35 (MIC=2 ?M), Escherichia coli ATCC 25922 (MIC=4 ?M), Salmonella typhimurium ATCC 14028 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ?M).##Gram-positive bacteria: Bacillus megaterium (MIC=2 ?M), Staphylococcus aureus ATCC 25923 (MIC=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	8132502	J Biol Chem. 1994 Mar 18;269(11):7855-7858.	"Zanetti M, Storici P, Tossi A, Scocchi M, Gennaro R."	Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells.
DRAMP02961	GLLSRLRDFLSDRGRRLGEKIERIGQKIKDLSEFFQS	37	"Antibacterial peptide PMAP-37 (Myeloid antibacterial peptide 37; pigs, mammals, animals)"	P49932	Belongs to the cathelicidin family	PMAP37	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Alpha helix 	Not found	None	"Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria with minimal inhibitory concentrations ranging over 1-4 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes.
PTM: Contains two disulfide bonds (By similarity)."	"Gram-negative bacteria: Escherichia coli ML35 (MIC=2 ?M), Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli D21 (MIC=2 ?M), Salmonella typhimurium ATCC 14028 (MIC=4 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=2 ?M).##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=4 ?M), Bacillus megaterium local isolate (IC=4 ?M), Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan 1 (MIC=64 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	7737198	Eur J Biochem. 1995 Mar 15;228(3):941-946.	"Tossi A, Scocchi M, Zanetti M, Storici P, Gennaro R."	"PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity."
DRAMP02228	SMLSVLKNLGKVGLGFVACKINKQC	25	"RANATUERIN 1 (Frogs, amphibians, animals)"	P82741 	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. Has activity against C.albicans. Has no detectable hemolytic activity.	[Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Yeast: Candida albicans (MIC=70 ?M).	[Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20?g/ml against human red blood cell.	Cyclic	Free	Cyclization (Cys19 and Cys25)	Disulfide bond between Cys19 and Cys25.	L	No cytotoxicity information found	Not found	9784389	Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592.	"Goraya J, Knoop FC, Conlon JM."	"Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana."
DRAMP02963	GRFRRLRKKTRKRLKKIGKV	20	PMAP-36(1-20)	No entry found	Not found	Not found	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. 	"Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6 ?M), Bacillus megaterium Bm11 (MIC=3 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12 ?M), E. coli ML35 (MIC=12 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=48 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=3 ?M).##Fungi: Candida albicans c.i. (MIC>64 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16128809	FEBS J. 2005 Sep;272(17):4398-4406.	"Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A."	Structural aspects and biological properties of the cathelicidin PMAP-36.
DRAMP02964	GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLG	34	PMAP-36(1-34)	No entry found	Not found	Not found	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. 	"Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1 ?M), S. aureus 710A (MIC=2 ?M), S. aureus SA-62 (MRSA) (MIC=4 ?M), Bacillus megaterium Bm11 (MIC=1 ?M), S. epidermidis ATCC 12228 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), E. coli ML35 (MIC=1 ?M), E. coli D21 (MIC=1 ?M), E. coli D22 (MIC=0.5 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 ?M), S. enterica ser. Enteritidis H2 (MIC=1 ?M), P. aeruginosa ATCC 27853 (MIC=1 ?M), S. marcescens ATCC 8100 (MIC=2 ?M).##Fungi: Candida albicans c.i. (MIC=8 ?M), Cryptococcus neoformans c.i.(MIC=2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16128809	FEBS J. 2005 Sep;272(17):4398-4406.	"Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A."	Structural aspects and biological properties of the cathelicidin PMAP-36.
DRAMP02965	GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLGC	35	PMAP-36(1-35)2	No entry found	Not found	Not found	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. 	"Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), S. aureus 710A (MIC=2 ?M), S. aureus SA-62 (MRSA) (MIC=4 ?M), Bacillus megaterium Bm11 (MIC=1 ?M), S. epidermidis ATCC 12228 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), E. coli ML35 (MIC=0.5 ?M), E. coli D21 (MIC=0.5 ?M), E. coli D22 (MIC=0.5 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 ?M), S. enterica ser. Enteritidis H2 (MIC=0.5 ?M), P. aeruginosa ATCC 27853 (MIC=1 ?M), S. marcescens ATCC 8100 (MIC=2 ?M).##Fungi: Candida albicans c.i. (MIC=16 ?M), Cryptococcus neoformans c.i.(MIC=2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16128809	FEBS J. 2005 Sep;272(17):4398-4406.	"Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A."	Structural aspects and biological properties of the cathelicidin PMAP-36.
DRAMP02966	KQATVGDINTERPGILDLKGKAKWDAWNGLKGTSKEDAMKAYINKVEELKKKYGI	55	"DBI(32-86) (pigs, mammals, animals)"	"P12026, A7YB23, Q9TSG2"	Belongs to the ACBP family	DBI	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: DBI(32-86) has antibacterial properties.	Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.69 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=30 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8375398##3289918	Eur J Biochem. 1993 Sep 1;216(2):623-629.##Eur J Biochem. 1988 Jun 1;174(2):239-245.	"Agerberth B, Boman A, Andersson M, J?rnvall H, Mutt V, Boman HG.##Chen ZW, Agerberth B, Gell K, Andersson M, Mutt V, Ostenson CG, Efendi? S, Barros-S?derling J, Persson B, J?rnvall H."	"Isolation of three antibacterial peptides from pig intestine: gastric inhibitory polypeptide (7-42), diazepam-binding inhibitor (32-86) and a novel factor, peptide 3910.##Isolation and characterization of porcine diazepam-binding inhibitor, a polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release."
DRAMP02970	RGGRLCYCRRRFCVCVGR	18	"Protegrin-1 (Protegrin 1; PG-1; pigs, mammals, animals)"	P32194	Belongs to the cathelicidin family	NPG1	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Beta strand	Not found	1PG1 resolved by NMR.	The sequence of IB-367 is RGGLCYCRGRFCVCVGR and the peptide is active against bacteria and fungi. This peptide showed synergistic effect with LL-37 against P. aeruginosa and E. coli (Yan H & Hancock REW 2001 Antimicrob Agents Chemother 45: 1558-60). PG-1 derivatives were subjected to clinical trials. 	"Gram-negative bacteria: Escherichia coli (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=64 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bond between Cys6 and Cys15,Cys8 and Cys13."	L	"[Ref.31399625] Cytotoxicity: 661W cells(IC50=353.4¡À70.5¦ÌM), HEK293T cells(IC50=2760¡À54.1¦ÌM), NIH-3T3 cells(IC50=719.2¡À59.5¦ÌM), SH-SY5Y cells(IC50=590.4¡À58.2¦ÌM), PMN cells(IC50=948.9¡À64.1¦ÌM), and 3D4/2 cells(IC50=391.1¡À71.3¦ÌM)"	Cell membrane	8647100	Chem Pharm Bull (Tokyo). 1995 May;43(5):853-858.	"Tamamura H, Murakami T, Horiuchi S, Sugihara K, Otaka A, Takada W, Ibuka T, Waki M, Yamamoto N, Fujii N."	Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity.
DRAMP02975	VRRFPWWWPFLRR	13	"Tritrpticin (Trp-rich; pigs, mammals, animals)"	No entry found	Belongs to the cathelicidin family	Not found	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix (1 helices; 3 residues)	Not found	1D6X resolved by NMR.	Function: Tritrpticin has strong antimicrobial activity with a wide spectrum.	"Gram-negative bacteria: Escherichia coli (5 mm), Pseudomonas aeruginosa (3 mm), Klebsiella pneumonia (7 mm), Proteus mirabilis (1 mm);##Gram-positive bacteria: Staphylococcus epidermidis (5 mm), Streptococcus group D (4 mm). [inhibit zones in mm]##Fungi: Aspergillus fumigatus (MIC=250 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8706838##10606506	FEBS Lett. 1996 Jul 15;390(1):95-98.##Biochemistry. 1999 Dec 21;38(51):16749-55.	"Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K.Schibli DJ, Hwang PM, Vogel HJ.##Schibli DJ, Hwang PM, Vogel HJ."	Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides.##Structure of the antimicrobial peptide tritrpticin bound to micelles: a distinct membrane-bound peptide fold.
DRAMP03028	IDWKKLLDAAKQIL	14	Polybia-MP1	No entry found	Not found	Not found	Polybia paulista	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.	"[Ref.29075946] Gram-positive bacterium: Bacillus subtilis (MIC=12.5¦ÌM), Staphylococcus aureus (MIC=18.8¦ÌM);##Gram-negative bacterium:Escherichia coli (MIC=75¦ÌM), Shigella dysenteriae (MIC=75¦ÌM), Klebsiella pneumoniae (MIC=37.5¦ÌM)"	"[Ref.29075946] <1% hemolysis at 12.5¦ÌM, 3.2% hemolysis at 25¦ÌM against human red blood cells."	stapled peptide	Free	Amidation	tethers Lys6 and Arg10	L	No cytotoxicity information found	Not found	29075946	Arch Pharm Res. 2017 Dec;40(12):1414-1419.	"Luong HX, Kim DH, Lee BJ, Kim YW"	Antimicrobial activity and stability of stapled helices of polybia-MP1
DRAMP03721	ILGKIWEGIKSLF	13	IsCT1	Q8MMJ7 	Belongs to the scorpion NDBP 5 family	Not found	Opisthacanthus madagascariensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	"Residue 6 is important for antibacterial activity, and hemolysis activity"	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.	"[Ref.28657596] Gram-positive bacterium:Staphylococcus aureus (MIC=50¦Ìg/mL);##Gram-negative bacterium: S. typhimurium (MIC=100¦Ìg/mL), Escherichia coli (MIC=50¦Ìg/mL)"	"[Ref.28657596] 2% hemolysis at 10 ¦Ìg/ml, 96% hemolysis at 50 ¦Ìg/ml against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28657596	Antibiotics (Basel). 2017 Jun 28;6(3). pii: E13.	"de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM."	Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides
DRAMP01377	FMPILSCSRFKRC	13	"Odorranain-G1 (OdG1; Frogs, amphibians, animals)"	"A6MBL7, A6MBL8"	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Odorranain-G1 adopts 44.1% ¦Â-sheet structure in water solution.	None	Function: Odorranain-G1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ¦Ìg/ml), Bacillus subtilis (MIC=37.5 ¦Ìg/ml).##Yeast: Candida albicans (MIC=1.10 ¦Ìg/ml)."	[Ref:17272268] It has no hemolytic activity against rabbit red blood cells	Cyclic	Free	Cyclization (Cys7 and Cys13)	Disulfide bond between Cys7 and Cys13.	L	No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP02995	QERGSIVIQGTKEGKSRPSLDIDYKQRVYDKNGMTGDAYGGLNIRPGQPSRQHAGFEFGKEYKNGFIKGQSEVQRGPGGRLSPYFGINGGFRF	93	"Hymenoptaecin (Insects, animals)"	Q10416	Not found	Not found	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli K514 (MIC=0.5-1 ?M), E. coli K514 anaerobic, E. coli NCTC9001 (MIC=1-5 ?M), Xanthomonas campestris (MIC=0.5-1 ?M), Pseudomonas solanacearum (MIC>10 ?M), Erwinia carotovora ssp.(MIC=1-5 ?M);##Gram-positive bacteria: Micrococcus lysodeikticus (MIC=1-5 ?M), Bacillus megaterium (MIC=0.5-1 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8463238	J Biol Chem. 1993 Apr 5;268(10):7044-7054.	"Casteels P, Ampe C, Jacobs F, Tempst P."	"Functional and chemical characterization of Hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera)."
DRAMP02996	GNNRPIYIPQPRPPHPRL	18	"Apidaecin-2 (Apidaecin II; Insects, animals)"	"Q06601, P11525, P11526, P11527"	Belongs to the apidaecin family	APID14	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 ?g/ml), Erwinia salicis (MIC=0.02 ?g/ml), Escherichia coli (MIC=0.2 ?g/ml), Pseudomonas syringae (MIC=0.1 ?g/ml), Rhizobium meliloti (MIC=0.02 ?g/ml), Salmonella Newport (MIC=0.2 ?g/ml), Salmonella typhimurium (MIC=0.1 ?g/ml);##Gram-positive bacteria: Shigella flexneri (MIC=0.1 ?g/ml), Corynebacterium insidiosum (MIC=100 ?g/ml), Bacillus megaterium (MIC=100 ?g/ml)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2676519	EMBO J. 1989 Aug;8(8):2387-2391.	"Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P."	Apidaecins: antibacterial peptides from honeybees.
DRAMP02441	VXLFPVXLFP	10	Gramicidin S	No entry found	Not found	Not found	Bacillus brevis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Beta sheet and beta-turn	The peptide have the C2-symmetrical sequence [cyclo-(Val-Orn-Leu-D-Phe-Pro)2]. The two sequences Val-Orn-Leu form an antiparallel 	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.	"[Ref.29499484] Gram-positive bacterium:Staphylococcus aureus subsp.aureus CIP 4.83 ATCC 6538 (MIC=3.125¦Ìg/mL),Bacillus subtilis subsp. subtilis CIP 52.65 (MIC=3.125¦Ìg/ml),Enterococcus faecalis CIP 103015 (MIC=3.125¦Ìg/ml),Enterococcus faecalis CIP 103214 (MIC=3.125¦Ìg/ml),Bacillus cereus CIP 66.24 (MIC=6.25¦Ìg/ml),Streptococcus salivarius CIP 102503 (MIC=3.125¦Ìg/ml),Enterococcus faecium CIP 103014 (MIC=3.125¦Ìg/ml);##Gram-negative bacterium:Escherichia coli CIP 53.126 ATCC 8739 (MIC=12.5¦Ìg/ml),Pseudomonas aeruginosa CIP 82.118 ATCC 9027 (MIC>=100¦Ìg/ml)"	"[Ref.29499484] It has 74% hemolysis at 50¦Ìg/ml, 83% hemolysis at 100¦Ìg/ml against human red blood cells."	Cyclic	No specific N-terminal	No specific C-terminal	The 'O' in sequence is Ornithine	Mixed(D-Phe)	No cytotoxicity information found	Not found	29499484	Eur J Med Chem. 2018 Apr 10;149:122-128.	"Wan Y, Stanovych A, Gori D, Zirah S, Kouklovsky C, Alezra V."	"¦Â,¦Ã-diamino acids as building blocks for new analogues of Gramicidin S: Synthesis and biological activity"
DRAMP02998	GNNRPVYIPQPRPPHPRI	18	"Apidaecin-1A (Apidaecin IA; Insects, animals)"	"Q06602, P11525, P11526"	Belongs to the apidaecin family	APID73	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 ?g/ml), Erwinia salicis (MIC=0.02 ?g/ml), Escherichia coli (MIC=0.1 ?g/ml), Pseudomonas syringae (MIC=0.2 ?g/ml), Rhizobium meliloti (MIC=0.1 ?g/ml), Salmonella Newport (MIC=0.2 ?g/ml), Salmonella typhimurium (MIC=0.1 ?g/ml), Shigella flexneri (MIC=0.1 ?g/ml);##Gram-positive bacteria: Corynebacterium insidiosum (MIC=50 ?g/ml), Bacillus megaterium (MIC=150 ?g/ml)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2676519	EMBO J. 1989 Aug;8(8):2387-2391.	"Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P."	Apidaecins: antibacterial peptides from honeybees.
DRAMP02999	PFKISIHL	8	"Jellein-1 (Jelleine-I; chain of Major royal jelly protein 1; Insects, animals)"	"O18330, Q548D6"	Belongs to the major royal jelly protein family	MRJP1	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Jellein-1 has antibacterial and antifungal activity.
Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee.
Developmental stage: Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee.
Miscellaneous: Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival. Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days. PTM: Histidine amide at H7."	"Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=10 ?g/ml), S. saprophyticus (MIC=15 ?g/ml), Bacillus subtilis CCT 2471 (MIC=10 ?g/ml).##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=2.5 ?g/ml), Enterobacter cloacae ACCT 23355 (MIC=10 ?g/ml), Klebsiella pneumoniae ACCT 13883 (MIC=10 ?g/ml), Pseudomonas aeruginosa ACCT 27853 (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=2.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15203237##9395329##21516106	Peptides. 2004 Jun;25(6):919-928.##Eur J Biochem. 1997 Nov 1;249(3):797-802.##Nature. 2011 May 26;473(7348):478-483.	"Fontana R, Mendes MA, de Souza BM, Konno K, C¨¦sar LM, Malaspina O, Palma MS.##Ohashi K, Natori S, Kubo T.##Kamakura M."	Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).##Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.##Royalactin induces queen differentiation in honeybees.
DRAMP03000	TPFKISIHL	9	"Jellein-2 (Jelleine-II; chain of Major royal jelly protein 1; Insects, animals)"	"O18330, Q548D6"	Belongs to the major royal jelly protein family	MRJP1	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Jellein-2 has antibacterial and antifungal activity. Jellein-2 is probably processed to yield jellein-1 and jellein-4.
Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee.
Developmental stage: Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee.
Miscellaneous: Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival. Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days. PTM: Leucine amide at L9."	"Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=15 ?g/ml), S. saprophyticus (MIC=10 ?g/ml), Bacillus subtilis CCT 2471 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=15 ?g/ml), Enterobacter cloacae ACCT 23355 (MIC=15 ?g/ml), Klebsiella pneumoniae ACCT 13883 (MIC=15 ?g/ml), Pseudomonas aeruginosa ACCT 27853 (MIC=15 ?g/ml).##Yeast: Candida albicans (MIC=2.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15203237##9395329##21516106	Peptides. 2004 Jun;25(6):919-928.##Eur J Biochem. 1997 Nov 1;249(3):797-802.##Nature. 2011 May 26;473(7348):478-483.	"Fontana R, Mendes MA, de Souza BM, Konno K, C¨¦sar LM, Malaspina O, Palma MS.##Ohashi K, Natori S, Kubo T.##Kamakura M."	Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).##Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.##Royalactin induces queen differentiation in honeybees.
DRAMP03001	EPFKISIHL	9	"Jellein-3 (Jelleine-III; Insects, animals)"	P84759	Not found	MRJP1	Apis mellifera (Honeybee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Jellein-3 has antibacterial and antifungal activity.
Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee.
PTM: Leucine amide at L9."	"Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=30 ?g/ml), S. saprophyticus (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT1371 (MIC=15 ?g/ml), Enterobacter cloacae ATCC 23355, Klebsiella pneumoniae ATCC 13883, Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?g/ml).##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15203237	Peptides. 2004 Jun;25(6):919-928.	"ntana R, Mendes MA, de Souza BM, Konno K, C¨¦sar LM, Malaspina O, Palma MS."	Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).
DRAMP03057	GSKKPVPIIYCNRRTGKCQRM	21	"Thanatin(insects, arthropods, invertebrates, animals)"	P55788 	Not found	Not found	Podisus maculiventris	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand	"Contain C-terminally a loop of 6 residues, delineated by an intramolecular disulfide bridge. This loop carries a strong positive charge in both molecules and contains a central threonine residue, which separates two subgroups of electropositivity."	8TFV	Function: Insect defense peptide with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and fungi. No activity against S.aureus. Stops respiration in bacteria but does not permeabilize their inner membranes. Has no detectable hemolytic activity. 	"[Ref.8577744] Gram-positive bacteria: Aerococcus viridans (MIC=0.6-1.2 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Bacillus subtilis (MIC=2.5-5 ?M), Pediococcus acidilactici (MIC=20-40 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.3-0.6 ?M), Escherichia coli D31 (MIC=0.3-0.6 ?M), Escherichia coli 1106 (MIC=0.6-1.2 ?M), Salmonella typhimurium (MIC=0.6-1.2 ?M), Klebsiella pneumoniae (MIC=0.6-1.2 ?M), Enterobacter cloacae (MIC=1.2-2.5 ?M), Erwinia carotovora (MIC=10-20 ?M), Pseudomonas aeruginosa (MIC=20-40 ?M);##Fungi: Neurospora crassa (MIC=0.6-1.2 ?M), Botrytis cinerea (MIC=1.2-2.5 ?M), Nectria haematococca (MIC=1.2-2.5 ?M), Trichoderma viride (MIC=1.2-2.5 ?M), Alternaria brassicicola (MIC=2.5-5 ?M), Fusarium culmorum (MIC=2.5-5 ?M), Ascochyta pisi (MIC=5-10?M), Fusarium oxysporum (MIC=10-20 ?M)."	[Ref.8577744] It exhibits no hemolytic activity at 40 ?M against porcine erythrocytes.	Cyclic	Free	Free	Disulfide bond between Cys11 and Cys18.	L	No cytotoxicity information found	Not found	8577744##9760181	Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.##Eur J Biochem. 1998 Sep 1;256(2):404-410.	"Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA.##Mandard N, Sodano P, Labbe H, Bonmatin JM, Bulet P, Hetru C, Ptak M, Vovelle F."	"Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.##Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data."
DRAMP03003	GFLSILKKVLPKVMAHMK	18	"Melectin (MEP; Insects, animals)"	P86170	Not found	Not found	Melecta albifrons (Cuckoo bee) (Melecta punctata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity against Gram-positive bacteria as well as Gram-negative bacteria. Stimulates degranulation from rat peritoneal mast cells with an EC50 of 19.4 ?M. Has weak hemolytic activity towards rat erythrocytes.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation."	"[Ref.18942691]Gram-positive bacteria: Bacillus subtilis (MIC=0.8 ?M), Staphylococcus aureus (MIC=6.8 ?M);##Gram-negative bacteria: Escherichia coli (MIC=2.0 ?M), Pseudomonas aeruginosa (MIC=18.5 ?M)."	[Ref.18942691]LC50>100 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18942691	Chembiochem. 2008 Nov 24;9(17):2815-2821.	"Cerovsk? V, Hovorka O, Cvacka J, Voburka Z, Bedn¨¢rov¨¢ L, Borovickov¨¢ L, Slaninov¨¢ J, Fuc¨ªk V."	Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons.
DRAMP03007	GFLSALKKYLPIVLKHV	17	"Osmin (Insects, animals)"	P0CD70	Not found	Not found	Osmia rufa (Red mason bee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (CD)	"In absence of TFE, the spectrum shows a random coil type structure. When increasing the concentration of TFE from 0 to 20%, a transition into an ¦Á-helix structure is observed."	None	"Function: Synthetic peptide exhibits hemolytic activity to human erythrocytes and inhibits bacterial and fungal growth at micromolar concentrations. A synthetic peptide with a free C-terminus shows weaker hemolytic (5.0 HU/mg), antibacterial and antifungal activities.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation."	[Ref.19109988]Gram-positive bacterium: Micrococcus luteus (MIC=1.56-0.78 ?M);##Gram-negative bacterium: Escherichia coli SBS363 (MIC=3.125-1.56 ?M);##fungi: Fusarium oxysporum (MIC=0.78-0.39 ?M).	[Ref.19109988]5.0 HU/mg hemolytic activity against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19109988	Toxicon. 2010 Jan;55(1):20-27.	"?cklin R, Favreau P, Thai R, Pflugfelder J, Bulet P, Mebs D."	Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (hymenoptera: megachilidae).
DRAMP03019	INWLKLGKKILGAL	14	Mastoparan PDD-B	No entry found	Belongs to the mastoparan family	Not found	Polistes dorsalis dorsolis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity. PDD-B has hemolytic activity.	[Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=70 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15.5 ?M).	[Ref.18375018]IC50=45 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP03020	INWKKIFEKVKNLV	14	Mastoparan PDD-A	No entry found	Belongs to the mastoparan family	Not found	Polistes dorsalis dorsolis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity. PDD-A shows little hemolytic activity.	[Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=11.8 ?M);##Gram-negative bacterium: Escherichia coli (MIC=7.5 ?M).	[Ref.18375018]IC50>100 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP03021	INWKKIASIGKEVLKAL	17	Mastoparan PMM	No entry found	Belongs to the mastoparan family	Not found	Polistes major major	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity. Shows hemolytic activity.	[Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=7.3 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25.8 ?M).	[Ref.18375018]IC50=80 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP03022	INWLKLGKKMMSAL	14	Mastoparan MP	No entry found	Belongs to the mastoparan family	Not found	Mischocyttarus phthisicus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Has antibacterial activity. Has hemolytic activity.	[Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli (MIC=65 ?M).	[Ref.18375018]IC50=100 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP01739	LLPIVGNLLKSLL	13	"Temporin-B (Frogs, amphibians, animals)"	P79874 	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	6GIL resolved by NMR.	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has hemolytic activity.
PTM: Leucine amide at position 13.
Tissue specificity: Expressed by the skin glands."	"[Ref.9022710] Gram-positive bacteria: Bacillus megaterium BM11 (LC=2.8 ?M), Staphylococcus aureus Cowanl (LC=6.0 ?M), Streptococcus pyogenes betahemolytic group A (LC=7.0 ?M);##Gram-negative bacteria: Escherichia coli D21(LC=21.0 ?M), Escherichia coli D21e7 (LC=13.2 ?M), Escherichia coli D21f1 (LC=10.0 ?M), Escherichia coli D21f2 (LC=3.3 ?M), Escherichia coli D22 (LC=11.2 ?M),Yersinia pseudotuberculosis (LC=7.0 ?M), Pseudomonas aeruginosa ATCC15692 (LC>360 ?M);##Yeast: Candida albicans (LC=4.0 ?M).(LC: Lethal concentration).##[Ref.28443279] Gram-positive bacterium: S.aureus ATCC 33591 (MIC=12¦ÌM), Staphylococcus epidermidis (MIC=6¦ÌM);##Gram-negative bacterium: Klebsiella pneumoniae ATCC BAA-1706 (MIC=48¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=48¦ÌM)"	[Ref.9022710] LC>120 ?M against Human red blood cells. (LC: Lethal concentration)##[Ref.28443279] 1% hemolysis at 96¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9022710##28443279	Eur J Biochem. 1996 Dec 15;242(3):788-792.##Front Chem. 2017 Apr 11;5:24.	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.##Grassi L, Maisetta G, Maccari G, Esin S, Batoni G."	"Temporins, antimicrobial peptides from the European red frog Rana temporaria.##Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide"
DRAMP03033	INWKGIAAMAKKLL	14	"Mastoparan-like peptide 12a (Insects, animals)"	P0C1M4	Not found	Not found	Vespa magnifica (Hornet)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Mast cell degranulating peptide. Has little hemolytic activity.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (Leucine amide: L14). "	[Ref.17046111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 ?g/ml);##Fungi: Candida albicans ATCC 2002 (MIC=3.7 ?g/ml).	[Ref.16330062]Little hemolytic activity at 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16330062##17046111	Toxicon. 2006 Feb;47(2):249-253.##Peptides. 2006 Dec;27(12):3053-3057.	"Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.##Xu X, Yang H, Yu H, Li J, Lai R."	Two families of antimicrobial peptides from wasp (Vespa magnifica) venom.##The mastoparanogen from wasp.
DRAMP03034	INWKGIAAMKKLL	13	"Mastoparan-like peptide 12b (Insects, animals)"	P0C1M5	Not found	Not found	Vespa magnifica (Hornet)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Mast cell degranulating peptide. Has little hemolytic activity. Shows antimicrobial activity.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (Leucine amide: L13)."	[Ref.16330062]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 ?g/ml);##Fungi: Candida albicans ATCC 2002 (MIC=7.5 ?g/ml).	[Ref.16330062]Little hemolytic activity at 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16330062	Toxicon. 2006 Feb;47(2):249-53. Epub 2005 Dec 5. Peptides. 2006 Dec;27(12):3053-7. Epub 2006 Oct 13.	"Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.Xu X, Yang H, Yu H, Li J, Lai R."	Two families of antimicrobial peptides from wasp (Vespa magnifica) venomThe mastoparanogen from wasp.
DRAMP03035	INLKAIAALAKKLLG	15	"Mastoparan-like peptide 12c (Insects, animals)"	A0SPI0	Not found	Not found	Vespa magnifica (Hornet)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Shows mast cell degranulation and antimicrobial activities.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (Leucine amide: L14). "	Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.0 ?g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=12.0 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17046111	Peptides. 2006 Dec;27(12):3053-3057.	"Xu X, Yang H, Yu H, Li J, Lai R."	The mastoparanogen from wasp.
DRAMP03036	INLKAIAAMAKKLL	14	"Mastoparan-like peptide 12d (Insects, animals)"	P0C5G7	Not found	Not found	Vespa magnifica (Hornet)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Shows mast cell degranulation and antimicrobial activities.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (Leucine amide: L14). "	Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=1.5 ?g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=12.0 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17046111	Peptides. 2006 Dec;27(12):3053-3057.	"Xu X, Yang H, Yu H, Li J, Lai R."	The mastoparanogen from wasp.
DRAMP03037	LNLKGIFKKVASLLT	15	"Eumenitin (Er-12; Insects, animals)"	P0C931	Not found	Not found	Eumenes rubronotatus (Solitary wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Cationic linear alpha-helical antimicrobial peptide that binds preferentially to charged lipid membranes as compared with zwitterionic ones. It exhibits inhibitory activity against both Gram-positive and Gram-negative bacteria, and moderately stimulates degranulation from the rat peritoneal mast cells. Does not show hemolytic activity. May play a role in preventing infection by microorganisms during prey consumption by their larvae.
Tissue specificity: Expressed by the venom gland."	"[Ref.16762455]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC>60 ?M), Staphylococcus aureus ATCC 25923 (MIC=6 ?M), Staphylococcus saprophytius (CS) (MIC=6 ?M), Staphylococcus epidermius (CS) (MIC>60 ?M), Bacillus subtilis CCT 2471 (MIC=60 ?M), Bacillus thuringiensis (WT) (MIC>60 ?M);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=6 ?M), Escherichia coli ATCC 25922 (MIC=6 ?M), Escherichia cloacae ATCC 23355 (MIC>60 ?M), Proteus mirabilis (CS) (MIC>60 ?M), Pseudomonas aeruginosa ATCC 15442 (MIC=30 ?M)."	[Ref.16762455]Non-hemolytic activity against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen	16762455##18206199	Peptides. 2006 Nov;27(11):2624-2631.##Toxicon. 2008 Apr;51(5):736-745.	"Konno K, Hisada M, Naoki H, Itagaki Y, Fontana R, Rangel M, Oliveira JS, Cabrera MP, Neto JR, Hide I, Nakata Y, Yasuhara T, Nakajima T.##Arcisio-Miranda M, dos Santos Cabrera MP, Konno K, Rangel M, Procopio J."	"Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus.##Effects of the cationic antimicrobial peptide eumenitin from the venom of solitary wasp Eumenes rubronotatus in planar lipid bilayers: surface charge and pore formation activity."
DRAMP03038	LNLKGLIKKVASLLN	15	"Eumenitin-R (Insects, animals)"	P0CJ36	Not found	Not found	Eumenes rubrofemoratus (Solitary wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes.
Tissue specificity: Expressed by the venom sac."	"[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=60 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=15 ?M), Streptococcus pyogenes (clinical sample) (MIC=15 ?M), Bacillus subtilis ATCC 6633 (MIC=7.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 ?M);##Fungi: Candida albicans ATCC 90112 (MIC<7.5 ?M)."	[Ref.21549739]EC50=530.3 ¦ÌM against mice erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen	21549739	Toxicon. 2011 Jun;57(7-8):1081-1092.	"Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K."	Chemical and biological characterization of four new linear cationic ?¡À-helical peptides from the venoms of two solitary eumenine wasps.
DRAMP03039	LNLKGLFKKVASLLT	15	"Eumenitin-F (Insects, animals)"	P0CJ37	Not found	Not found	Eumenes fraterculus (Solitary wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes.
Tissue specificity: Expressed by the venom sac."	"[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>60 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=30 ?M), Streptococcus pyogenes (clinical sample) (MIC=30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC>60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)."	[Ref.21549739]EC50=353.4 ¦ÌM against mice erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen	21549739	Toxicon. 2011 Jun;57(7-8):1081-1092.	"Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K."	Chemical and biological characterization of four new linear cationic ?¡À-helical peptides from the venoms of two solitary eumenine wasps.
DRAMP03040	FDVMGIIKKIAGAL	14	"Eumenine mastoparan-EF (EMP-EF; Insects, animals)"	P0CJ39	Not found	Not found	Eumenes fraterculus (Solitary wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes.
Tissue specificity: Expressed by the venom sac.
PTM: C-terminal amidation (Leucine amide: L14)."	"[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=30 ?M), Streptococcus pyogenes (clinical sample) (MIC>30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)."	[Ref.21549739]EC50=181.1 ¦ÌM against mice erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen	21549739	Toxicon. 2011 Jun;57(7-8):1081-1092.	"Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K."	Chemical and biological characterization of four new linear cationic ?¡À-helical peptides from the venoms of two solitary eumenine wasps.
DRAMP03041	FDIMGLIKKVAGAL	14	"Eumenine mastoparan-ER (EMP-ER; Insects, animals)"	P0CJ38	Not found	Not found	Eumenes rubrofemoratus (Solitary wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes.
Tissue specificity: Expressed by the venom sac.
PTM: C-terminal amidation (Leucine amide: L14)."	"[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC>30 ?M), Streptococcus pyogenes (clinical sample) (MIC>30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)."	[Ref.21549739]EC50=200 ¦ÌM against mice erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen	21549739	Toxicon. 2011 Jun;57(7-8):1081-1092.	"Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K."	Chemical and biological characterization of four new linear cationic ?¡À-helical peptides from the venoms of two solitary eumenine wasps.
DRAMP03042	INLLKIAKGIIKSL	14	"Eumenine mastoparan-AF (EMP-AF; Af-113; Insects, animals)"	P0C022	Not found	Not found	Anterhynchium flavomarginatum micado (Solitary wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	"Function: Mast cell degranulating peptide. Also permeates anionic liposomes. Has hemolytic activity. Has an amphiphilic alpha-helix conformation. Shows broad-spectrum antimicrobial activity. Blocks the lobster neuromuscular transmission. Induces the depolarization of the muscle membrane.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (Leucine amide: L14)."	"[Ref.15317499]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC=5 ?g/ml), S. saprophyticus CS (MIC=5 ?g/ml), S. epidermidis CS (MIC=5 ?g/ml), Bacillus subtilis CCT 2471 (MIC=40 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=20 ?g/ml), Escherichia coli ATCC 25922 (MIC=50 ?g/ml), Pseudomonas aeruginosa ATCC 15442 (MIC=20 ?g/ml)."	[Ref.10775751]100% hemolytic activity against human erythrocytes at 10^-4 M	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen	15317499##11006592##10775751	J Pept Res. 2004 Sep;64(3):95-103.##Rapid Commun Mass Spectrom. 2000;14(19):1828-1834.##Toxicon. 2000 Nov;38(11):1505-1015.	"dos Santos Cabrera M.P, de Souza B.M, Fontana R, Konno K, Palma M.S, de Azevedo W.F. Jr, Neto J.R.##Hisada M, Konno K, Itagaki Y, Naoki H, Nakajima T.##Konno K, Hisada M, Naoki H, Itagaki Y, Kawai N, Miwa A, Yasuhara T, Morimoto Y, Nakata Y."	"Conformation and lytic activity of eumenine mastoparan: a new antimicrobial peptide from wasp venom.##Advantages of using nested collision induced dissociation/post-source decay with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: sequencing of novel peptides from wasp venom.##Structure and biological activities of eumenine mastoparan-AF (EMP-AF), a new mast cell degranulating peptide in the venom of the solitary wasp (Anterhynchium flavomarginatum micado)."
DRAMP03043	INWLKLGKAIIDAL	14	"Agelaia-mastoparan (Agelaia-MP; Insects, animals)"	P69436	Not found	Not found	Agelaia pallipes pallipes (Neotropical social wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Hemolytic mast cell degranulator, presenting no antimicrobial action and no chemotaxis for polymorphonucleated leukocytes (PMNL).
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (Leucine amide: L14)."	"[Ref.15225564]Gram-negative bacteria: Escherichia coli (MIC=382 ?g/ml), Pseudomonas aeruginosa (MIC=257 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=237 ?g/ml), Staphylococcus aureus (MIC=191 ?g/ml)."	[Ref.15225564]70% hemolytic activity at 156 ng/ml against rat erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15225564##15052574	Toxicon. 2004 Jul;44(1):67-74.##Rapid Commun Mass Spectrom. 2004;18(6):636-642.	"Mendes MA, de Souza BM, Marques MR, Palma MS.##Mendes MA, Monson de Souza B, Delazari dos Santos L, Palma MS."	Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes.##Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
DRAMP03044	ILGTILGLLKGL	12	"Protonectin (Agelaia-chemotactic peptide, Agelaia-CP; Insects, animals)"	P69437	Not found	Not found	Agelaia pallipes pallipes (Neotropical social wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Mast cell degranulator that induces a potent chemotaxis in polymorphonucleated leukocyte (PMNL) cells. Shows potent antimicrobial action against both Gram-positive and Gram-negative bacteria. Shows no hemolytic activity.	"[Ref.15225564]Gram-negative bacteria: Escherichia coli (MIC=25 ?g/ml), Pseudomonas aeruginosa (MIC=1.7 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=3.1 ?g/ml), Staphylococcus aureus (MIC=12.5 ?g/ml)."	[Ref.15052574]Non-hemolytic activity against rat red blood cell	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15225564##15052574	Toxicon. 2004 Jul;44(1):67-74.##Rapid Commun Mass Spectrom. 2004;18(6):636-642.	"Mendes MA, de Souza BM, Marques MR, Palma MS.##Mendes MA, Monson de Souza B, Delazari dos Santos L, Palma MS."	Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes.##Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
DRAMP03045	VTCELLMFGGVVGDSACAANCLSMGKAGGSCNGGLCDCRKTTFKELWDKRFG	52	"Defensin-NV (Insects, animals)"	No entry found	Not found	Not found	Nasonia vitripennis (Ectoparasitic wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Bridge	Not found	None	"Function: Defensin-NV had little hemolytic activity to rabbit red blood cells and has antimicrobial activity against Gram-positive, Gram-negative bacteria, and Fungi."	"[Ref.20362606]Gram-positive bacteria: Staphylococcus aureus (MIC=0.93 ?M), Bacillus cereus (MIC=0.93 ?M), B. dysenteriae (MIC=0.46 ?M);##Gram-negative bacteria: Escherichia coli (MIC=1.86 ?M), Pseudomonas aeruginosa (MIC=9.3 ?M).##Yeast: Candida albicans (MIC=1.86 ?M)."	[Ref.20362606]5% hemolytic activity at 200 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20362606	Toxicon. 2010 Aug 1;56(1):101-106.	"Ye J, Zhao H, Wang H, Bian J, Zheng R."	A defensin antimicrobial peptide from the venoms of Nasonia vitripennis.
DRAMP03047	EPILGIITSLLKSL	14	"Venom peptide 2-long (OdVP2L; analog of OdVP2; Insects, animals)"	"P86147, C7DT08"	Belongs to the MCD family (Protonectin subfamily)	VP2	Orancistrocerus drewseni (Solitary wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations.
Tissue specificity: Expressed by the venom gland."	"[Swiss_Prot Entry P86147]Fungi: Botrytis cinerea (MIC=0.5 ?g/ml), Candida albicans (MIC=100 ?g/ml);##Gram-positive bacterium: S. aureus (MIC=25 ?g/ml);##Gram-negative bacterium: Escherichia coli."	[Swiss_Prot Entry P86147]has potent hemolytic activity against ovine erythrocytes at micromolar concentrations	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19857508##18695936	Toxicon. 2010 Apr 1;55(4):711-718.##Amino Acids. 2009 Jul;37(2):389-394.	"Baek JH, Lee SH.##Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T."	"Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).##Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni."
DRAMP03050	INWKKIAEVGGKILSSL	17	"Dominulin-A (Insects, animals)"	P0C1M6	Belongs to the MCD family (Mastoparan subfamily)	Not found	Polistes dominulus (European paper wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Shows antimicrobial activity.	Gram-positive bacterium: Bacillus subtilis ATCC 6633 (MIC=2 ?g/ml);##Gram-negative bacterium: Escherichia coli JM109 (MIC=8 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16446098	J Am Soc Mass Spectrom. 2006 Mar;17(3):376-383.	"Turillazzi S, Mastrobuoni G, Dani FR, Moneti G, Pieraccini G, la Marca G, Bartolucci G, Perito B, Lambardi D, Cavallini V, Dapporto L."	"Dominulin A and B: two new antibacterial peptides identified on the cuticle and in the venom of the social paper wasp Polistes dominulus using MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap."
DRAMP03051	INWKKIAEIGKQVLSAL	17	"Dominulin-B (Insects, animals)"	P0C1M7	Belongs to the MCD family (Mastoparan subfamily)	Not found	Polistes dominulus (European paper wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Shows antimicrobial activity.	Gram-positive bacterium: Bacillus subtilis ATCC 6633 (MIC=2 ?g/ml);##Gram-negative bacterium: Escherichia coli JM109 (MIC=8 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16446098	J Am Soc Mass Spectrom. 2006 Mar;17(3):376-383.	"Turillazzi S, Mastrobuoni G, Dani FR, Moneti G, Pieraccini G, la Marca G, Bartolucci G, Perito B, Lambardi D, Cavallini V, Dapporto L."	"Dominulin A and B: two new antibacterial peptides identified on the cuticle and in the venom of the social paper wasp Polistes dominulus using MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap."
DRAMP03055	YVPPVQKPHPNGPKFPTFP	19	"PP30 (Pro-rich; abaecin-like; Insects, animals)"	No entry found	Not found	Not found	Pteromalus puparum (wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=23.3¡À2.1 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=16.7¡À2.1 ?M), Staphylococcus aureus (MIC=133.3¡À11.6 ?M), Sarcina lutea (MIC=13.3¡À1.2 ?M), Bacillus pumilu (MIC=13.3¡À2.1 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20466006	J Invertebr Pathol. 2010 Sep;105(1):24-29.	"Shen X, Ye G, Cheng X, Yu C, Altosaar I, Hu C."	Characterization of an abaecin-like antimicrobial peptide identified from a Pteromaluspuparum cDNA clone.
DRAMP03056	SLLSLIRKLIT	11	"Decoralin (Insects, animals)"	P85870	Not found	Not found	Oreumenes decoratus (Potter wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide. At high concentrations exhibits activity in stimulating degranulation from rat peritoneal mast cells. Inhibits the growth of L.major promastigotes in vitro with an IC50 of 72 ?M. Has hemolytic activity towards human and mouse erythrocytes.
Tissue specificity: Expressed by the venom gland."	"[Ref.17981364]Gram-positive bacteria: Staphylococcus aureus CCT 6538 (MIC=40 ?M), S. saprophyticus (MIC=40 ?M), Bacillus subtilis CCT 2471 (MIC=40 ?M), B. thuringiensis (MIC=40 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=80 ?M), Escherichia coli CCT 1371 (MIC=160 ?M), Klebsiella pneumoniae ATCC 13883 (MIC=80 ?M), A. faecalis ATCC 8750 (MIC=40 ?M);##Fungi: Candida albicans (MIC=40 ?M), L. major promastigotes (IC50=72 ?M)."	[Ref.17981364]EC50=1 mM against mouse erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	17981364	Peptides. 2007 Dec;28(12):2320-2327.	"Konno K, Rangel M, Oliveira JS, Dos Santos Cabrera MP, Fontana R, Hirata IY, Hide I, Nakata Y, Mori K, Kawano M, Fuchino H, Sekita S, Neto JR."	"Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus."
DRAMP03819	RRWWRF	6	Cyclic hexapeptide CYC-(RRWWRF)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Anti-Gram+, Anti-Gram-"	Synthetic	Non helix or strand structure (Turn)	Not found	"1QVK,1QVL"	Function: Antibacterial activity against Escherichia coli and Bacillus subtilis.  Has hemolytic activity.	[Ref.16075425] Gram-negative bacterium: Escherichia coli(MIC=6.3 ¦ÌM);##Gram-positive bacterium: Bacillus subtilis(MIC=3.1 ¦ÌM)	[Ref.16075425] It has 24% hemolysis at 100 ¦ÌM against erythrocytes.	Cyclic	No specific N-terminal	No specific C-terminal	None	L	No cytotoxicity information found	Not found	16075425##7883644	Chembiochem. 2005 Sep;6(9):1654-1662.##J Appl Bacteriol. 1995 Jan;78(1):39-46.	"Appelt C, Wessolowski A, S?derh??ll JA, Dathe M, Schmieder P.##Blondelle SE, Takahashi E, Dinh KT, Houghten RA."	"Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles.##The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries."
DRAMP03820	RRYYRF	6	Cyclic hexapeptide RRYYRF	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Anti-Gram+, Anti-Gram-"	Synthetic	Non helix or strand structure (Turn)	Not found	1SKI	Function: Antibacterial activity against Escherichia coli and Bacillus subtilis. Has hemolytic activity.	[Ref.16075425] Gram-negative bacterium: Escherichia coli(MIC>100 ¦ÌM);##Gram-positive bacterium: Bacillus subtilis(MIC>100 ¦ÌM)	[Ref.16075425] It has 1% hemolysis at 100 ¦ÌM against erythrocytes.	Cyclic	No specific N-terminal	No specific C-terminal	None	L	No cytotoxicity information found	Not found	16075425	Chembiochem. 2005 Sep;6(9):1654-1662.	"Appelt C, Wessolowski A, S?derh??ll JA, Dathe M, Schmieder P."	"Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles."
DRAMP03821	KKWWKF	6	Cyclic hexapeptide KKWWKF	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Anti-Gram+, Anti-Gram-"	Synthetic	Non helix or strand structure (Turn)	Not found	1SKK	Function: Antibacterial activity against Escherichia coli and Bacillus subtilis. Has hemolytic activity.	[Ref.16075425] Gram-negative bacterium: Escherichia coli(MIC=25 ¦ÌM);##Gram-positive bacterium: Bacillus subtilis(MIC=25 ¦ÌM)	[Ref.16075425] It has 10% hemolysis at 100 ¦ÌM against erythrocytes.	Cyclic	No specific N-terminal	No specific C-terminal	None	L	No cytotoxicity information found	Not found	16075425	Chembiochem. 2005 Sep;6(9):1654-1662.	"Appelt C, Wessolowski A, S?derh??ll JA, Dathe M, Schmieder P."	"Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles."
DRAMP03075	WNPFKELERAGQRVRDAIISAGPAVATVAQATALAK	36	Cecropin-D	P01511	Belongs to the cecropin family	Not found	Antheraea pernyi (Chinese oak silk moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
PTM: C-terminal amidation."	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.37 ?M), E. coli D31 (MIC=0.21 ?M), Serratia marsescens (MIC=6.1 ?M), S. marsescens Strain 122 (MIC=75 ?M), Pseudomonas aeruginosa OT97 (MIC>81 ?M), Xenorhabdus nematophilus Xn21 (MIC=16 ?M);##Gram-positive bacteria: Bacillus subtilis Bsll (MIC>81 ?M), Bacillus megaterium Bmll (MIC=24 ?M), Bacillus thuringiensis Btll (MIC>81 ?M), Streptococcus fecalis Ds16 (MIC>81 ?M), S. fecalis AD-4 (MIC>81 ?M), Micrococcus luteus MI11 (MIC=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	6754375	Eur J Biochem. 1982 Sep;127(1):219-224.	"Qu Z, Steiner H, Engstr?m A, Bennich H, Boman HG."	"Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi."
DRAMP03089	GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATAR	39	"Drosophila cecropin-A1/A2 (Insects, animals)"	"P14954, B3DN02, B3DN08, O16815, O16816, O16817, O16818, O16819, O16820"	Belongs to the cecropin family	CecA1 AND CecA2	Drosophila melanogaster (Fruit fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Tissue specificity: Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria. Maximal expression in the adult involves fat body cells of the head, thorax and abdomen.
Induction: Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food.
PTM: C-terminal amidation (By similarity)."	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.3 ?M), Enterobacter cloacae ¦Â12 (MIC=0.4 ?M), Pseudomonas aeruginosa OT97 (MIC=2.2 ?M), Serratia marcescens Db11 (MIC=93 ?M);##Gram-positive bacteria: Bacillus megatherium Bm11 (MIC=2.6 ?M), Bacillus subtilis Bsll (MIC=16 ?M), Micrococcus luteus MI11 (MIC=8.5 ?M). "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2104802##2390977##9725836	EMBO J. 1990 Jan;9(1):217-224.##EMBO J. 1990 Sep;9(9):2969-2976.	"Kylsten P, Samakovlis C, Hultmark D.##Samakovlis C, Kimbrell DA, Kylsten P, Engstr?m A, Hultmark D."	The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.##The immune response in Drosophila: pattern of cecropin expression and biological activity.
DRAMP03090	GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR	39	"Drosophila cecropin B (CecB; Insects, animals)"	"P14956, O16826, O16827, O16828, O18647, O61274, Q9V425"	Belongs to the cecropin family	CecB	Drosophila melanogaster (Fruit fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food. [Ref.1]"	"Gram-negative bacteria: Escherichia coli D21 (MIC=1.8 ?M), Enterobacter cloacae b12 (MIC=1.0 ?M), Pseudomonas aeruginosa OT97 (MIC=4.2 ?M);##Gram-positive bacteria: Bacillus megatherium Bm11 (MIC=3.7 ?M), Bacillus subtilis Bsll (MIC=3.2 ?M), Micrococcus luteus MI11 (MIC=59 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2390977##2104802	EMBO J. 1990 Sep;9(9):2969-2976.##EMBO J. 1990 Jan;9(1):217-224.	"Samakovlis C, Kimbrell DA, Kylsten P, Engstr?m A, Hultmark D.##Kylsten P, Samakovlis C, Hultmark D."	The immune response in Drosophila: pattern of cecropin expression and biological activity.##The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.
DRAMP03095	VFIDILDKVENAIHNAAQVGIGFAKPFEKLINPK	34	"Andropin (Insects, animals)"	"P21663, A9UNE4, O16822, O16823, O16824, Q6LAI1, Q9VA90"	Not found	Anp	Drosophila melanogaster (Fruit fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Andropin is constitutively expressed in the adult male ejaculatory duct in response to mating not bacterial infection. Andropin is less fungicidal than the cecropins (Insect Biochem Mol Biol. 1999;29:965-72). Along with other antimicrobial proteins, this peptide sterilizes the reproduction system of insects and protects sperms from being infected by bacteria (J Insect Physiol. 2001 Jun;47(6):617-622). Similarly, ceratotoxins are expressed in the female reproductive accesary glands and expressed during mating."	"Gram-negative bacteria: Escherichia coli D21 (MIC=140 ?M), Enterobacter cloacae b312 (MIC>300 ?M), Pseudomonas aeruginosa OT97 (MIC>300 ?M), Serratia marcescens Db 11 (MIC>127 ?M), Serratia marcescens Db 1140 (MIC>127 ?M);##Gram-positive bacteria: Bacillus megatherium Bml1 (MIC=11 ?M), Bacillus subtilis Bs11 (MIC=17 ?M), Micrococcus luteus MIll (MIC=20 ?M). "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1899226	EMBO J. 1991; 10:163-169.	"Samakovlis, C, Kylsten, P, Kimbrell, DA, Engstroem, A, Hultmark, D."	"The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster."
DRAMP18495	QCRRLCYKQRCVTYCRGR	18	"Gomesin (Gm; Spiders, arachnids, Chelicerata, arthropods, invertebrates, animals)"	P82358 	Belongs to the tachyplesin family	Not found	Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic, Antimalarial, Antic"	Protein level	Beta sheet	Not found	1KFP resolved by NMR.	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi. It shows hemolytic activity.
Tissue specificity: In hemocytes only, but not in all hemocytes observed."	"[Ref.10942757] Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 ¦ÌM), Bacillus cereus (MIC=6.25-12.5 ¦ÌM), Bacillus megaterium (MIC=0.2-0.4 ¦ÌM), Bacillus thuringiensis (MIC=1.6-3.15 ¦ÌM), Enterococcus faecalis (MIC=6.2-12.5 ¦ÌM), Listeria monocytogenes (MIC=0.8-1.6 ¦ÌM), Micrococcus luteus (MIC=0.4-0.8 ¦ÌM), Pediococcus acidolacrici (MIC=3.15-6.25 ¦ÌM), Staphylococcus aureus (MIC=1.6-3.15 ¦ÌM), Staphylococcus epidermidis (MIC=0.8-1.6 ¦ÌM), Staphylococcus haemolyticus (MIC=0.8-1.6 ¦ÌM), Staphylococcus saprophyticus (MIC=0.8-1.6 ¦ÌM), Streptococcus pyogenes (MIC=1.6-3.15 ¦ÌM), Nocardia asteroides (MIC=1.6-3.15 ¦ÌM);##Gram-negative bacteria: Escherichia coli 1106 (MIC=0.8-1.6 ¦ÌM), Escherichia coli D22 (MIC=0.4-0.8 ¦ÌM), Escherichia coli D31 (MIC=0.8-1.6 ¦ÌM), Escherichia coli SBS363 (MIC=0.4-0.8 ¦ÌM), Erwinia carolovora (MIC=3.15-6.25 ¦ÌM), Enterobacter cloacae ¦Â12 (MIC=3.15-6.25 ¦ÌM), Klebsiella pneumoniae (MIC=3.15-6.25 ¦ÌM), Pseudomonas aeruginosa (MIC=1.6-3.15 ¦ÌM), Salmonella thyphinurium (MIC=0.8-1.6 ¦ÌM), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 ¦ÌM);##Fungi: Alternaria brassicola (MIC=0.4-0.8 ¦ÌM), Aspergillus fumigatus (MIC=1.6-3.15 ¦ÌM), Beauveria bassiana (MIC=12.5-25 ¦ÌM), Fusarium culmorum (MIC=0.4-0.8 ¦ÌM), Fusarium oxysporum (MIC=0.4-0.8 ¦ÌM), Neurospora crassa (MIC=0.4-0.8 ¦ÌM), Nectria haematococca (MIC=0.2-0.4 ¦ÌM), Tricoderma viridae (MIC=0.4-0.8 ¦ÌM), Tricophvton mentagrophytes (MIC=0.8-1.6 ¦ÌM);##Yeasts: Candida albicans (MIC=0.15-0.3 ¦ÌM), Candida glabrata (MIC=12.5-25 ¦ÌM), Candida tropicalis (MIC=3.15-6.25 ¦ÌM), Cryptococcus neoformans (MIC=0.8-1.6 ¦ÌM), Saccharomyces cerevisiae (MIC=1.6-3.15 ¦ÌM)."	[Ref.10942757] It exhibits 16% hemolysis at 1 ¦ÌM and 100 ¦ÌM against human erythrocytes	Cyclic	pyroglutamic acid	Amidation	"Disulfide bond between Cys2 and Cys15,Cys6 and Cys11."	L	No cytotoxicity information found	Not found	10942757	J Biol Chem. 2000 Oct 27;275(43):33464-70.	"Silva PI Jr, Daffre S, Bulet P."	"Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family."
DRAMP03104	ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN	40	"Sapecin (defensins; Insects, animals)"	P18313	Belongs to the invertebrate defensin family (Type 1 subfamily)	Not found	Sarcophaga peregrina (Flesh fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	Not found	1L4V resolved by NMR.	"Function: Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria.
Tissue specificity: Hemocytes and fat body. Induction: By injury to the larval cell wall.
PTM: Contains three disulfide bonds 3-30; 16-36; 20-38."	"Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=5.0 ?g/ml), Staphylococcus smith (MIC=5.0 ?g/ml), Micrococcus luteus FDA16 (MIC=1.2 ?g/ml), Micrococcus luteus IF03333 (MIC=1.2 ?g/ml), Micrococcus luteus PC11001 (MIC=10.0 ?g/ml), Bacillus subtilis NRRI B-558 (MIC=39.0 ?g/ml), Bacillus subtilis PC1219 (MIC=20.0 ?g/ml), Mycobacterium smegmatis ATCC607 (MIC=78.0 ?g/ml), Corynebacterium bouis 1810 (MIC=2.5 ?g/ml), Corynebacterium michiganense (MIC=2.5 ?g/ml).##Gram-negative bacteria: Xantbmonas oryzae (MIC=20.0 ?g/ml), Pseudomonas lachrymans (MIC=78.0 ?g/ml), Escherichia coli NIHJ (MIC>78.0 ?g/ml), Shigella sonnei JS11746 (MIC>78.0 ?g/ml), Proteus vulgaris O X19 (MIC>78.0 ?g/ml) "	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bonds between Cys3 and Cys30; Cys16 and Cys36; Cys20 and Cys38.	L	No cytotoxicity information found	Not found	3182836##3182836##2358424	J Biol Chem. 1988 Nov 15;263(32):17117-17121.##J Biol Chem. 1988 Nov 15;263(32):17112-17116.##J Biochem. 1990 Apr;107(4):514-518.	"Matsuyama K, Natori S.##Matsuyama K, Natori S.##Kuzuhara T, Nakajima Y, Matsuyama K, Natori S."	"Molecular cloning of cDNA for sapecin and unique expression of the sapecin gene during the development of Sarcophaga peregrina.##Purification of three antibacterial proteins from the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina.##Determination of the disulfide array in sapecin, an antibacterial peptide of Sarcophaga peregrina (flesh fly)."
DRAMP03116	SLGGVISGAKKVAKVAIPIGKAVLPVVAKLVG	32	"Ceratotoxin-C (Insects, animals)"	Q17313	Not found	CTXC1 AND CTCX2	Ceratitis capitata (Mediterranean Fruit fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Has hemolytic activity.Temperature dependence: Thermostable. Still active at 100 degrees Celsius.	"[Ref.9569644]Gram-negative bacteria: Escherichia coli 23739 (MIC=13.6 ?M), Escherichia coli LE 392 (MIC=5 ?M), Pseudomonas aeruginosa 27853 (MIC>50 ?M), P. vulgaris 6380 (MIC>50 ?M), S. typhymurium 23853 (MIC>5 ?M);##Gram-positive bacteria: E. cloacae 13047 (MIC>5 ?M), E. jaecalis 29212 (MIC>50 ?M), Staphylococcus aureus 25923 (MIC>50 ?M), B. cereus 9634 (MIC>5 ?M), Bacillus subtilis 6633 (MIC=5.9 ?M)."	[Swiss_Prot Entry Q17313]has hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9569644	Eur. J. Biochem. 1996; 241:330-337.	"Rosetto M, Manetti AGO, Giordano PC, Marri L, Amons R, Baldari CT, Marchini D, Dallai R."	"Molecular characterization of ceratotoxin C, a novel antibacterial female-specific peptide of the ceratotoxin family from the medfly Ceratitis capitata."
DRAMP03117	QSEAGWLKKIGKKIERVGQHTRDATIQGLGVAQQAPNVAATAR	43	"Drosophila cecropin-A1 (Insects, animals)"	O61272	Belongs to the cecropin family	CecA1	Drosophila simulans (Fruit fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	"Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
PTM: C-terminal amidation (By similarity)."	"Gram-negative bacteria: Alcaligenes faecalis (MIC=10-25 ?M), Escherichia coli 1106 (MIC=0.25-0.5 ?M), Escherichia coli D22 (MIC=0.1-0.25 ?M), Escherichia coli D31 (MIC=0.1-0.25 ?M), Escherichia coli SBS363 (MIC=0.1-0.25 ?M), Enterobacter cloacae ¦Â12 (MIC=0.5-1 ?M), Erwinia carotovora (MIC=0.5-1 ?M), Klebsiella pneumoniae (MIC=1-2.5 ?M), Pseudomonas aeruginosa (MIC=1-2.5 ?M), Salmonella typhimurium (MIC=0.5-1 ?M), Xanthomonas campestris (MIC=0.5-1 ?M); ##Gram-positive bacteria: Aerococcus viridans (MIC=5-10 ?M), Bacillus megaterium (MIC=1-2.5 ?M), Micrococcus luteus (MIC=5-10 ?M).##Fungi: Botrytis cinerea (MIC=5-10 ?M), Fusarium culmorum (MIC=1-2.5 ?M), Fusarium oxysporum (MIC=1-2.5 ?M), Neurospora crassa (MIC=2.5-10 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9553148##9725836	Immunogenetics. 1998 May;47(6):417-429.##Genetics. 1998 Sep;150(1):157-171.##Insect Mol Biol. 2000 Feb;9(1):75-84.	"Date A, Satta Y, Takahata N, Chigusa S.I.##Ramos-Onsins S, Aguade M.##Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, M¨¹ller HM, Dimopoulos G, Hoffmann J, Kafatos FC, Richman A."	"Evolutionary history and mechanism of the Drosophila cecropin gene family.##Molecular evolution of the Cecropin multigene family in Drosophila: functional genes vs pseudogenes.##Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae."
DRAMP03138	GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL	34	"Cecropin-A (Insects, animals)"	"P82592, Q17NR3, Q95PI9"	Belongs to the cecropin family	CECA	Aedes aegypti (Yellowfever mosquito)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli D22 (MIC=0.25-0.5 ?g/ml), E. coli D31 (MIC=0.25-0.5 ?g/ml), E. coli SBS363 (MIC=0.1-0.25 ?g/ml), E. coli 1106 (MIC=0.25-0.5 ?g/ml), Enterobacter cloacae b12 (MIC=50-100 ?g/ml), E. carotovora (MIC=0.25-0.5 ?g/ml), Klebsiella pneumoniae (MIC=1-2.5 ?g/ml), Pseudomonas aeruginosa (MIC=10-25 ?g/ml), Salmonella typhimurium (MIC=1-2.5 ?g/ml), X. campestris (MIC=0.5-1 ?g/ml);##Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 ?g/ml), Bacillus megaterium (MIC=1-2.5 ?g/ml), Micrococcus luteus (MIC=10-25 ?g/ml), Streptococcus pyogenes (MIC=10-25 ?g/ml).##Fungi: Fusarium culmorum (MIC=1-2.5 ?g/ml), Fusarium oxysporum (MIC=2.5-5 ?g/ml), Neurospora crassa (MIC=5-10 ?g/ml), Candida albicans (MIC=25-50 ?g/ml), Cryptococcus neoformans (MIC=25-50 ?g/ml), Saccharomyces cerevisiae (MIC=50-100 ?g/ml) "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10400619	J Biol Chem. 1999 Jul 16;274(29):20092-20097.	"Lowenberger C, Charlet M, Vizioli J, Kamal S, Richman A, Christensen BM, Bulet P."	"Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti."
DRAMP03140	GRLKKLGKKIEGAGKRVFKAAEKALPVVAGVKALG	35	"Anopheles cecropin-A amidated isoform (Insects, animals)"	"P82290, A7XAX5, A7XAX7, A7XAY1, A7XAY8, A7XAZ7, A7XB12, A7XB23, Q7QEE3"	Belongs to the cecropin family	CecA	Anopheles gambiae (African malaria mosquito)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against several Gram-positive and Gram-negative bacteria. Also has antifungal activity.
Tissue specificity: Relatively abundant in head, thorax and to a lesser extent in abdominal carcass and anterior midgut.
Developmental stage: In young pupae, expressed within 2 hours of infection and continued to accumulate over 16 hours.
Induction: By bacterial infection.
PTM: C-terminal amidation."	"Gram-negative bacteria: Alcaligenes faecalis (MIC=1-2.5 ?M), Escherichia coli 1106 (MIC=0.5-1 ?M), E. coli D22 (MIC=0.1-0.25 ?M), E. coli D31 (MIC=0.1-0.25 ?M), E. coli SBS363 (MIC=0.05-0.1 ?M), Enterobacter cloacae ¦Â12 (MIC=0.5-1 ?M), Erwinia carotovora (MIC=0.5-1 ?M), Klebsiella pneumoniae (MIC=1-2.5 ?M), Pseudomonas aeruginosa (MIC=1-2.5 ?M), Salmonella typhimurium (MIC=0.1-0.25 ?M), Xanthomonas campestris (MIC=0.5-1 ?M); ##Gram-positive bacteria: Aerococcus viridans (MIC=0.5-1 ?M), Bacillus cereus (MIC=50-100 ?M), Bacillus megaterium (MIC=0.5-1 ?M), Listeria monocytogenes (MIC=50-100 ?M), Micrococcus luteus (MIC=0.5-1 ?M), Staphylococcus aureus (MIC=50-100 ?M), Staphylococcus epidermidis (MIC=10-25 ?M), Staphylococcus haemolyticus (MIC=1-2.5 ?M), Staphylococcus saprophyticus (MIC=1-2.5 ?M), Streptococcus pyogenes (MIC=0.1-0.25 ?M).##Fungi: Aspergillus fumigatus (MIC=5-10 ?M), Botrytis cinerea (MIC=1-2.5 ?M), Fusarium culmorum (MIC=0.5-1 ?M), Fusarium oxysporum (MIC=1-2.5 ?M), Neurospora crassa (MIC=1-2.5 ?M), Candida albicans (MIC=1-2.5 ?M), Cryptococcus neoformans (MIC=5-10 ?M), Saccharomyces cerevisiae (MIC=25-50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10672074##12421409	Insect Mol Biol. 2000 Feb;9(1):75-84.##Insect Mol Biol. 2002 Dec;11(6):517-525.	"Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, M¨¹ller HM, Dimopoulos G, Hoffmann J, Kafatos FC, Richman A.##Zheng XL, Zheng AL."	"Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae.##Genomic organization and regulation of three cecropin genes in Anopheles gambiae."
DRAMP03150	MVFAYAPTCARCKSIGARYCGYGYLNRKGVSCDGQTTINSCEDCKRKFGRCSDGFITECFL	61	"Gambicin (Insects, animals)"	No entry found	Not found	Not found	Anopheles albimanus (mosquito)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic"	Not found	Bridge	Not found	None	"Function: In vitro experiments showed that the 6.8-kDa mature peptide can kill both Gram-positive and Gram-negative bacteria, has a morphogenic effect on a filamentous fungus, and is marginally lethal to Plasmodium berghei ookinetes.
Induction: Predominantly expressed in the anterior part.
PTM: Contains four disulfide bridges."	Gram-negative bacterium: E. coli (MIC=6.25-12.5 ?M);##Gram-positive bacterium: M. luteus (MIC=25-50 ?M).##Fungus: N. crassa.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys9 and Cys20; Cys12 and Cys32; Cys41 and Cys51,Cys44 and Cys59."	L	No cytotoxicity information found	Not found	11606751	Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12630-5.	"Vizioli J, Bulet P, Hoffmann JA, Kafatos FC, M¨¹ller HM, Dimopoulos G."	Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae.
DRAMP03153	GIGGKPVQTAFVDNDGIYD	19	27 kDa antibacterial protein	P81925	Not found	Not found	Cyprinus carpio (common carp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has antibacterial activity. Forms large ion channels responsible for disrupting the cellular envelope of bacteria leading to cell lysis.	"Gram-positive bacteria: Staphylococcus aureus (MIC=5 ?g/ml), Micrococcus luteus (MIC=0. 5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=5 ?g/ml), Pseudomonas fluorescens (MIC=10 ?g/ml), Aeromonas hydrophila (MIC=5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	8797847	Eur J Biochem. 1996 Aug 15;240(1):143-149.	"Lema??tre C, Orange N, Saglio P, Saint N, Gagnon J, Molle G."	Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio).
DRAMP03166	IRNSLTCRFNFGICLPKRCPGRMRQIGTCF	30	"P15 (deer beta-defensin; ruminant, animals)"	No entry found	Not found	Not found	Cervus elaphus (New Zealand deer)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: It shows strong activity against Gram-negative bacteria, but lesser activity against Gram-positive bacteria and yeast.
Caution: the sequence displayed is N-terminal sequence of P15. "	Gram-negative bacterium: Escherichia coli O111 (MIC=0.3 ?g/mL);##Gram-positive bacterium: Staphylococcus aureus NCTC 4163 (MIC=1 ?g/mL).##Fungi: Candida albicans 3135A (MIC=3 ?g/mL).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16011891	Int J Antimicrob Agents. 2005 Aug;26(2):165-169.	"Treffers C, Chen L, Anderson RC, Yu PL."	Isolation and characterisation of antimicrobial peptides from deer neutrophils.
DRAMP03173	RWCVYAYVRVRGVLVRYRRCW	21	"Arenicin-1 (Ar-1; marine polychaeta, animals)"	"Q5SC60, P84105"	Not found	Not found	Arenicola marina (Lugworm) (Lumbricus marinus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Cytotoxic"	Protein level	Beta strand (2 strands; 16 residues)	"Arenicin-1 is a two-stranded antiparallel ¦Â-sheet (Cys3-Val10 and Val13-Cys20) stabilized by nine intra-backbone hydrogen bonds and a disulfide bond between Cys3 and Cys20. The strands of the ¦Â-sheet are connected by a type I? ¦Â-turn. The surface of arenicin is amphiphilic, with distinct hydrophobic and hydrophilic areas (ref.2)."	2JSB resolved by NMR.	"Function: Has antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteriua as well as yeast C. albicans. Bacterial killing occurs within minutes and is accompanied by membrane permeabilization, membrane detachment and release of cytoplasm. Interaction of arenicin with reconstituted membranes that mimic the lipopolysaccharide-containing outer membrane or the phospholipid-containing plasma membrane of Gram-negative bacteria exhibited no pronounced lipid specificity.
PTM: Contains one disulfide bond 3-20.
Domian: Contains 1 BRICHOS domain."	"Gram-positive bacterium: Listeria monocytogenes EGD (MIC=0.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35p (MIC=4 ?g/ml), E. coli WBB01 (MIC=0.3 mM), E. coli ATCC 23716 (MIC=0.6 mM), Salmonella enterica R595 (MIC=0.3 mM), S. enterica R60 (MIC=1.25 mM), Proteus mirabilis R45 (MIC=0.6 mM).##Yeast: Candida albicans 820 (MIC=20 ?g/ml).##Human Jurkat T-cells: LD50>40 mM (35.5% lysis at 30 mM)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys20.	L	"[Ref.27940358] Cytotoxicity: human embryonic fibroblasts (HEF) and human red blood cells (hRBC)(IC50 for arenicin-1 in the presence or absence of 10% FBS were of 35 and 8 ¦ÌM,HC50 indicating 50% hemolysis after 24 h incubation, equaled to 16¦ÌM)."	Anionic lipid vesicles	15527787##17935487	FEBS Lett. 2004 Nov 5;577(1-2):209-214.##Biochem J. 2008 Feb 15;410(1):113-122.	"Ovchinnikova TV, Aleshina GM, Balandin SV, Krasnosdembskaya AD, Markelov ML, Frolova EI, Leonova YF, Tagaev AA, Krasnodembsky EG, Kokryakov VN.##Andr? J, Jakovkin I, Gr?tzinger J, Hecht O, Krasnosdembskaya AD, Goldmann T, Gutsmann T, Leippe M."	"Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina.##Structure and mode of action of the antimicrobial peptide arenicin."
DRAMP03181	HVDKKVADKVLLLKQLRIMRLLTRL	25	"Spinigerin (Insects, animals)"	P82357	Not found	Not found	Pseudacanthotermes spiniger (Termite)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	"1ZRW, 1ZRV resolved by NMR."	Function: Active against Gram-positive bacteria and Gram-negative bacteria and fungi.	"Gram-positive bacteria: Bacillus megaterium (MIC=0.8-1.5 ?M), Micrococcus luteus (MIC=0.8-1.5 ?M);##Gram-negative bacteria: Escherichia coli SBS363 (MIC=3-6 ?M), E. coli D22 (MIC=3-6 ?M), Klebsiella pneumoniae (MIC=50-100 ?M), Salmonella typhimurium (MIC=3-6 ?M), Pseudomonas aeruginosa (MIC=50-100 ?M).##Fungi: Trichoderma viride (MIC=1.5-3 ?M), Neurospora crassa (MIC=3-6 ?M), Fusarium culmorum (MIC=1.5-3 ?M), Nectria haematococca (MIC=0.4-0.8 ?M), Candida albicans (MIC=3-6 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11053427##16170803	J Biol Chem. 2001 Feb 9;276(6):4085-4092.##Biopolymers. 2006 Feb 5;81(2):92-103. 	"Lamberty M, Zachary D, Lanot R, Bordereau C, Robert A, Hoffmann JA, Bulet P.##Landon C, Meudal H, Boulanger N, Bulet P, Vovelle F."	"Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect.##Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation."
DRAMP03186	SFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW	38	"Spheniscin-2 (Sphe-2; penguin avian beta-defensin 103b; birds ,animals)"	P83430	Belongs to the beta-defensin family	Not found	Aptenodytes patagonicus (King penguin)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand (3 strands; 14 residues)	"The overall fold of Sphe-2 includes a three-stranded antiparallel beta-sheet stabilized by three disulfide bridges with a pairing typical of beta-defensins. In addition, the N-terminal segment shows helical features on most structures.(Ref.2)"	1UT3 resolved by NMR.	"Function: Has antimicrobial activity. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane Function: with its amphipathic structure.
PTM: Contains three disulfide bond: 5-33; 12-27; 17-34.
Preserving food in the bird somach for several weeks during egg incubation. The disulfide bond pattern is identical to canonical beta-defensins from mammals. The high potency is related to its high cationicity as well as a hydrophobic patch, which is not observed in mammalian defensins. "	"[Ref.14525994]Gram-positive bacteria: Micrococcus luteus (MIC=1.5-3.0 ?M), Bacillus subtilis (MIC=0.8-1.5 ?M), Bacillus cereus ATCC 11778 (MIC=3-6 ?M), Bacillus megaterium (MIC=0.4-0.8 ?M), Staphylococcus aureus (MIC=1.5-3.0 ?M), Staphylococcus saprophyticus (MIC=1.5-3.0 ?M), Staphylococcus haemolyticus (MIC=1.5-3.0 ?M), Nocardia asteroides (MIC=0.8-1.5 ?M), Aerococcus viridans (MIC=0.4-0.8 ?M), Listeria monocytogenes (MIC=6-12 ?M);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=0.8-1.5 ?M), Escherichia coli 1106 (MIC=1.5-3.0 ?M), Salmonella typhimurium (MIC=6-12 ?M), Klebsiella pneumoniae (MIC=50-100 ?M), Pseudomonas aeruginosa ATCC 82118 (MIC=6-12 ?M), Vibrio metschnikovii NCTC 8483 (MIC=25-50 ?M), Vibrio anguillarum ATCC 19264 (MIC=25-50 ?M);##Fungi: Candida glabrata (MIC>100 ?M), Candida albicans IHEM 8060 (MIC=50-100 ?M), Candida tropicalis (MIC=1.5-3.0 ?M), Neurospora crassa (MIC=3-6 ?M),Aspergillus fumigatus (MIC=3-6 ?M)."	It has hemolytic activity	Cyclic	Free	Free	Disulfide bonds between Cys5 and Cys33; Cys12 and Cys27; Cys17 and Cys34.	L	No cytotoxicity information found	Not found	14525994##15123713	J Biol Chem. 2003 Dec 19;278(51):51053-51058.##J Biol Chem. 2004 Jul 16;279(29):30433-30439.	"Thouzeau C, Le Maho Y, Froget G, Sabatier L, Le Bohec C, Hoffmann JA, Bulet P.##Landon C, Thouzeau C, Labb¨¦ H, Bulet P, Vovelle F."	"Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus.##Solution structure of spheniscin, a beta-defensin from the penguin stomach."
DRAMP03187	QRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCR	36	"Beta defensin 1(BD-1; mammals, animals)"	P83943	Belongs to the beta-defensin family	DEFB1	Chinchilla lanigera (Long-tailed chinchilla) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has antibacterial and antifungal activity. May have a role in maintaining sterility in the middle ear.	Gram-negative bacterium: Moraxella catarrhalis (MIC=5 ?g/ml);##Gram-positive bacterium: Streptococcus pneumoniae (MIC=5 ?g/ml).##Fungi: Candida albicans (MIC=12.5-20 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14996845	J Biol Chem. 2004 May 7;279(19):20250-20256.	"Harris RH, Wilk D, Bevins CL, Munson RS Jr, Bakaletz LO."	Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway.
DRAMP03198	ACYCRIPACFAGERRYGTCFYLGRVWAFCC	30	"Alpha-defensin PhD-4 (primates, mammals, animals)"	P86724	Belongs to the alpha-defensin family	Not found	Papio hamadryas (Hamadryas baboon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity in low salt conditions, and the antimicrobial activity decreases significantly at high physiological salt concentrations.
PTM: Contains three disulfide bonds (By similarity)."	"In low salt conditions: Gram-negative bacterium: E. coli ML35p (MIC=2.4 ?M),;##Gram-positive bacteria: Listeria monocytogenes EGD (MIC=2.2 ?M), methicillin-resistant S. aureus ATCC 33591 (MIC=3.5 ?M).##Fungi: Candida albicans 820 (MIC=3.9 ?M).##At high physiological salt concentrations: E. coli ML35p (MIC=7.1 ?M), L. monocytogenes EGD (MIC=1.8 ?M), S. aureus ATCC 33591 (MIC>50 ?M), Candida albicans 820 (MIC>50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20155756	Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604.	"Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R."	De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.
DRAMP03215	ZCRRLCYKQRCVTYCRGR	18	"Gomesin (Gm; spiders, Arthropods, animals)"	"P82358, Q86RA2"	Not found	Not found	Acanthoscurria gomesiana (Tarantula spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Protein level	Beta strand	"Gm adopts a well-defined ¦Â-hairpin-like struc ture, and the disulfide bonds have been reported to be important for the maintenance of this structure."	1KFP resolved by NMR.	"[Ref.10942757]Function: Gomesin bound to the cell surface of cryptococci neoformans, which resulted in cell death associated with membrane permeabilization (FEMS Microbiol Lett. 2007 Sep;274(2):279-86). Also, this peptide triggers SH-SY5Y cell death through L-type channel calcium influx, MAPK/ERK, PKC and PI3K signaling and generation of reactive oxygen species (Soletti RC et al 2010 Chem Biol Interact 186: 135-43). Although represented by E, the N-terminal residue is a pyroglutamate. In hemocytes only, but not in all hemocytes observed.##[Ref.28741926]Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.10942757]Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 ?M), Bacillus cereus (MIC=6.25-12.5 ?M), Bacillus megaterium (MIC=0.2-0.4 ?M), Bacillus thuringiensis (MIC=1.6-3.15 ?M), Enterococcus faecalis (MIC=6.2-12.5 ?M), Listeria monocytogenes (MIC=0.8-1.6 ?M), Micrococcus luteus (MIC=0.4-0.8 ?M), Pediococcus acidolacrici (MIC=3.15-6.25 ?M), Staphylococcus aureus (MIC=1.6-3.15 ?M), S. epidermidis (MIC=0.8-1.6 ?M), S. haemolyticus (MIC=0.8-1.6 ?M), S. saprophyticus (MIC=0.8-1.6 ?M), Streptococcus pyogenes (MIC=1.6-3.15 ?M), Nocardia asteroides (MIC=1.6-3.15 ?M);##Gram-negative bacteria: Alcaligenes faecalis (MIC>100 ?M), Escherichia coli 1106 (MIC=0.8-1.6 ?M), E. coli D22 (MIC=0.4-0.8 ?M), E. coli D31 (MIC=0.8-1.6 ?M), E. coli SBS363 (MIC=0.4-0.8 ?M), Erwinia carolovora carolovora (MIC=3.15-6.25 ?M), Enterobacter cloacae beta 12 (MIC=3.15-6.25 ?M), Klebsiella pneumoniae (MIC=3.15-6.25 ?M), Pseudomonas aeruginosa (MIC=1.6-3.15 ?M), Salmonella typhimurium (MIC=0.8-1.6 ?M), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 ?M).##Fungi: Alternaria brassicola (MIC=0.4-0.8 ?M), Aspergillus fumigatus (MIC=1.6-3.15 ?M), Beauveria bassiana (MIC=12.5-25 ?M), Fusarium culmorum (MIC=0.4-0.8 ?M), F. oxysporum (MIC=0.4-0.8 ?M), Neurospora crassa (MIC=0.4-0.8 ?M), Nectria haematococca (MIC=0.2-0.4 ?M), Tricoderma viridae (MIC=0.4-0.8 ?M), Tricophvton mentagrophytes (MIC=0.8-1.6 ?M), C. albicans (MIC=0.15-0.3 ?M), C. glabrata (MIC=12.5-25 ?M), C. tropicalis (MIC=3.15-6.25 ?M), C. neoformans (MIC=0.8-1.6 ?M), Saccharomyces cerevisiae (MIC=1.6-3.15 ?M).##[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MIC=32 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=4-8 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦ÌM), Helicobacter pylori ATCC 43504 (MIC>80 ¦ÌM);##Fungi : Candida albicans ATCC 90028 (MIC=8-16 ¦ÌM), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 ¦ÌM)"	"[Ref.28741926] It has 0% hemolysis at 6 ¦ÌM , 3% hemolysis at 10 ¦ÌM , 10% hemolysis at 5 ¦ÌM , 41.2-53.2% hemolysis at 64 ¦ÌM , 50% hemolysis at 100 ¦ÌM against human red blood cells"	Cyclic	pyroglutamic acid	Amidation 	"Disulfide bond between Cys2 and Cys15,Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 67.0 ¡À 5.0 ¦ÌM against CRL-1739, CC50 = 3.7 ¡À 0.2 ¦ÌM against MM96L, CC50 = 49.9 ¡À16.6¦ÌM against HFF-1, CC50 =54.1¡À5.0 ¦ÌM against HeLa, CC50 = 3.8 ¡À 0.3 ¦ÌM against K-562."	Not found	10942757##28741926	J Biol Chem. 2000 Oct 27;275(43):33464-33470.##ACS Chem Biol.?2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Silva PI Jr, Daffre S, Bulet P.##Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	"Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.##Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties"
DRAMP03216	GIRCPKSWKCKAFKQRVLKRLLAMLRQHAF	30	"Oxyopinin-4a (Oxt-4a; spiders, Arthropods, animals)"	"F8J4S0, P86350"	Not found	Not found	Oxyopes takobius (Lynx spider) (Oxyopes foliiformis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	2L3I resolved by NMR.	"Function: Disrupts cell membranes through the formation of pores Probable. Has antibacterial activity. Has hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the venom gland.
PTM: Contains one disulfide bond 4-10."	[Ref.21933345]Gram-positive bacteria: S. aureus (MIC=10 ?M) and Bacillus subtilis (MIC=0.5 ?M);##Gram-negative bacteria: P. fluorescens (MIC=1 ?M) and E. coli (MIC=0.5 ?M).	[Ref.21933345] EC50=7 ¦ÌM against human erythrocytes	Cyclic	Free	Free	Disulfide bond between Cys4 and Cys10.	L	No cytotoxicity information found	Cell membrane (Probable)	21933345	FEBS J. 2011 Nov;278(22):4382-4393.	"Dubovskii PV, Vassilevski AA, Samsonova OV, Egorova NS, Kozlov SA, Feofanov AV, Arseniev AS, Grishin EV."	Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin.
DRAMP03217	FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ	48	"M-oxotoxin-Ot1a (Oxyopinin-1, Oxki1; spiders, Arthropods, animals)"	P83247	Not found	Not found	Oxyopes takobius (Lynx spider) (Oxyopes foliiformis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal"	Protein level	Alpha helix 	Not found	None	"Function: Disrupts cell membranes, particularly those rich in phosphocholine, through formation of pores. Has antimicrobial activity against Gram-negative bacterium E. coli, Gram-positive bacteria B. subtilis and S. aureus, and hemolytic activity against sheep erythrocytes. Has insecticidal activity against S. frugiperda ovarian cells by opening non-selective ion channels. Enhances the insecticidal activity of spider venom neurotoxic peptides."	"[Ref.11976325]Gram-negative bacterium: Escherichia coli (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis, Staphylococcus aureus (MIC=6.2 ?M)."	[Ref.11976325]100% hemolytic activity at 50 ?M against sheep red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11976325##15328050	J Biol Chem. 2002 Jun 28;277(26):23627-23637.##Biochim Biophys Acta. 2004 Aug 30;1664(2):182-188.	"Corzo G, Villegas E, G¨®mez-Lagunas F, Possani LD, Belokoneva OS, Nakajima T.##Belokoneva OS, Satake H, Mal'tseva EL, Pal'mina NP, Villegas E, Nakajima T, Corzo G."	"Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.##Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size."
DRAMP03222	GFGALFKFLAKKVAKTVAKQAAKQGAKYVVNKQME	35	"M-ctenitoxin-Cs1a (M-CNTX-Cs1a; Cupiennin-1a; spiders, Arthropods, animals)"	P83619	Belongs to the cupiennin family	Not found	Cupiennius salei (Wandering spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal"	Protein level	Alpha helix (3 helices; 11 residues)	"The peptide adopts a helix-hinge-helix structure in a membrane mimicking solvent. The hinge may play a role in allowing the amphipathic N-terminal helix and polar C-terminal helix to orient independently upon membrane binding, in order to achieve maximal antibacterial efficacy.(Ref.2)"	2K38 resolved by NMR.	"Function: Has antimicrobial activity. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane Function: with its amphipathic structure. Synergistically increases the insecticidal activity of CSTX-1, CSTX-9, and CSTX-13 by up to 65%. Also inhibits the formation of nitric oxide by neuronal nitric oxide synthase. LD50 is 5.9 pmol/mg on Drosophila. "	"[Ref.11792701]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.31-0.63 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.31-0.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=0.31-0.63 ?M), Enterococcus faecalis ATCC 29212 (MIC=2.50-5.00 ?M)."	[Ref.11792701]EC50=24.4 ¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	calcium calmodulin	11792701##17319697	J Biol Chem. 2002 Mar 29;277(13):11208-11216.##Biochemistry. 2007 Mar 20;46(11):3576-3585.	"Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W.##Pukala TL, Boland MP, Gehman JD, Kuhn-Nentwig L, Separovic F, Bowie JH."	"Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).##Solution structure and interaction of cupiennin 1a, a spider venom peptide, with phospholipid bilayers."
DRAMP03225	GFGSLFKFLAKKVAKTVAKQAAKQGAKYVANKHME	35	"M-ctenitoxin-Cs1d (M-CNTX-Cs1d; Cupiennin-1d; spiders, Arthropods, animals)"	P83622	Belongs to the cupiennin family	Not found	Cupiennius salei (Wandering spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity. Has insecticidal activity. Probably acts by disturbing membrane Function: with its amphipathic structure.
Tissue specificity: Expressed by the venom gland.
Toxic dose: LD50 is 6.4 pmol/mg on Drosophila."	"[Ref.11792701]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.08-0.16 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.16-0.31 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=0.63-1.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=1.25-2.50 ?M)."	[Ref.11792701]Not determined	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11792701##10669026	J Biol Chem. 2002 Mar 29;277(13):11208-11216.##Toxicon. 2000 Mar;38(3):373-380.	"Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W.##Haeberli S, Kuhn-Nentwig L, Schaller J, Nentwig W."	"Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).##Characterisation of antibacterial activity of peptides isolated from the venom of the spider Cupiennius salei (Araneae: Ctenidae)."
DRAMP03226	SMWSGMWRRKLKKLRNALKKKLKGE	25	"M-zodatoxin-Lt1a (M-ZDTX-Lt1a; Latarcin-1, Ltc-1, Ltc1; spiders, Arthropods, animals)"	Q1ELT9	Belongs to the latarcin family	Not found	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (1 helices; 16 residues)	The Ltc1 molecule is found to form a straight uninterrupted amphiphilic helix comprising 8-23 residues. The hydrophobic surface of the Ltc1 helix is narrow-shaped and extends with no gradient along the axis. (Ref.2)	2PCO resolved by NMR.	"Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae."	"[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.5 ?M), Bacillus subtilis VKM B-501 (MIC=1.0 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 ?M), Escherichia coli MH1 (MIC=0.7?M), Pseudomonas aeruginosa PAO1 (MIC=4.1 ?M);##Fungi: Pichia pastoris GS115 (MIC=17 ?M), Saccharomyces cerevisiae Y190 (MIC>33 ?M)."	[Ref.16735513]20% hemolytic activity at 80 ¦ÌM against rabbit erythrocytes 	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16735513##18293934	J Biol Chem. 2006 Jul 28;281(30):20983-20992.##Biochemistry. 2008 Mar 18;47(11):3525-3533.	"Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.##Dubovskii PV, Volynsky PE, Polyansky AA, Karpunin DV, Chupin VV, Efremov RG, Arseniev AS."	"Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.##Three-dimensional structure/hydrophobicity of latarcins specifies their mode of membrane activity."
DRAMP03227	GLFGKLIKKFGRKAISYAVKKARGKH	26	"M-zodatoxin-Lt2a (M-ZDTX-Lt2a; Latarcin-2a, Ltc-2a, Ltc2a; spiders, Arthropods, animals)"	Q1ELU1	Belongs to the latarcin family	Not found	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (2 helices; 18 residues)	The molecule of Ltc2a is found to consist of two helical regions (residues 3-9 and 13-21) connected via a poorly ordered fragment.	2G9P resolved by NMR.	"Function: Has hemolytic activity against Rabbit erythrocytes and has toxicity to ovarian insect Sf9 cells (EC50=20 ?M). Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. "	"[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 ?M), Bacillus subtilis VKM B-501 (MIC=0.4 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 ?M), Escherichia coli MH1 (MIC=0.7 ?M), Pseudomonas aeruginosa PAO1 (MIC=6.7 ?M);##Fungi: Pichia pastoris GS115 (MIC=6.7 ?M), Saccharomyces cerevisiae Y190 (MIC=54 ?M)."	[Ref.16735513]20% hemolytic activity at 6 ¦ÌM against rabbit erythrocytes 	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16735513##16939228	J Biol Chem. 2006 Jul 28;281(30):20983-20992.##Biochemistry. 2006 Sep 5;45(35):10759-10767.	"Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.##Dubovskii PV, Volynsky PE, Polyansky AA, Chupin VV, Efremov RG, Arseniev AS."	"Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.##Spatial structure and activity mechanism of a novel spider antimicrobial peptide."
DRAMP03229	SWKSMAKKLKEYMEKLKQRA	20	"M-zodatoxin-Lt3a (M-ZDTX-Lt3a; Latarcin-3a, Ltc-3a; spiders, Arthropods, animals)"	Q1ELU3	Belongs to the latarcin family	Not found	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.
Tissue specificity: Expressed by the venom gland."	"[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 MIC=1.2 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=2.5 ?M), Escherichia coli MH1 (MIC=6.0 ?M), Pseudomonas aeruginosa PAO1 (MIC>40 ?M);##Fungi: Pichia pastoris GS115 (MIC=20 ?M), Saccharomyces cerevisiae Y190 (MIC=20 ?M)."	[Ref.16735513]20% hemolytic activity at >120 ¦ÌM against rabbit erythrocytes 	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16735513	J Biol Chem. 2006 Jul 28;281(30):20983-209892.	"Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV."	"Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity."
DRAMP03230	SWASMAKKLKEYMEKLKQRA	20	"M-zodatoxin-Lt3b (M-ZDTX-Lt3b; Latarcin-3b, Ltc-3b; spiders, Arthropods, animals)"	Q1ELU2	Belongs to the latarcin family	Not found	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Has hemolytic against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.
Tissue specificity: Expressed by the venom gland."	"[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 ?M), Bacillus subtilis VKM B-501 (MIC=2.9 ?M);Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=23 ?M), Escherichia coli MH1 (MIC=28 ?M), Pseudomonas aeruginosa PAO1 (MIC>45 ?M);##Fungi: Pichia pastoris GS115 (MIC=23 ?M), Saccharomyces cerevisiae Y190 (MIC=23 ?M)."	[Ref.16735513]20% hemolytic activity at >120 ¦ÌM against rabbit erythrocytes 	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16735513	J Biol Chem. 2006 Jul 28;281(30):20983-209892.	"Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV."	"Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity."
DRAMP03231	GLKDKFKSMGEKLKQYIQTWKAKF	24	"M-zodatoxin-Lt4a (M-ZDTX-Lt4a; Latarcin-4a, Ltc-4a; spiders, Arthropods, animals)"	Q1ELU5	Belongs to the latarcin family	Not found	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.
Tissue specificity: Expressed by the venom gland."	"[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 (MIC=1.1 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=4.5 ?M), Escherichia coli MH1 (MIC=3.2 ?M), Pseudomonas aeruginosa PAO1 (MIC>35 ?M);##Fungi: Pichia pastoris GS115 (MIC=36 ?M), Saccharomyces cerevisiae Y190 (MIC=18 ?M)."	[Ref.16735513]20% hemolytic activity at >120 ¦ÌM against rabbit erythrocytes 	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16735513	J Biol Chem. 2006 Jul 28;281(30):20983-209892.	"Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV."	"Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity."
DRAMP03232	SLKDKVKSMGEKLKQYIQTWKAKF	24	"M-zodatoxin-Lt4b (M-ZDTX-Lt4b; Latarcin-4b, Ltc-4b; spiders, Arthropods, animals)"	Q1ELU4	Belongs to the latarcin family	Not found	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.
Tissue specificity: Expressed by the venom gland."	"[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 (MIC=1.1 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=4.4 ?M), Escherichia coli MH1 (MIC=4.4 ?M), Pseudomonas aeruginosa PAO1 (MIC>35 ?M);##Fungi: Pichia pastoris GS115 (MIC>35 ?M), Saccharomyces cerevisiae Y190 (MIC=35 ?M)."	[Ref.16735513]20% hemolytic activity at >120 ¦ÌM against rabbit erythrocytes 	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16735513	J Biol Chem. 2006 Jul 28;281(30):20983-209892.	"Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV."	"Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity."
DRAMP03233	GFFGKMKEYFKKFGASFKRRFANLKKRL	28	"M-zodatoxin-Lt5a (M-ZDTX-Lt5a; Latarcin-5, Ltc-5; spiders, Arthropods, animals)"	Q1ELU9	Belongs to the latarcin family	Not found	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Has antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria and and yeasts. Also has hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.
Tissue specificity: Expressed by the venom gland. PTM: Leucine amide at L28."	"[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=1.1 ?M), Bacillus subtilis VKM B-501 (MIC=0.6 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=0.6 ?M), Escherichia coli MH1 (MIC=0.6 ?M), Pseudomonas aeruginosa PAO1 (MIC=18 ?M);##Fungi: Pichia pastoris GS115 (MIC>37 ?M), Saccharomyces cerevisiae Y190 (MIC>37 ?M)."	[Ref.16735513]20% hemolytic activity at 40 ¦ÌM against rabbit erythrocytes 	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16735513	J Biol Chem. 2006 Jul 28;281(30):20983-20992. 	"Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV. "	"Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity."
DRAMP03236	GFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKYYGKKALQKASEKL	69	"M-zodatoxin-Lt8a (M-ZDTX-Lt8a; Cytoinsectotoxin-1a, CIT-1a; spiders, Arthropods, animals)"	"P85253, B3W6H9"	Belongs to the cytoinsectotoxin family	cit 1-1	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal"	Protein level	Not found	Not found	None	"Function: Insecticidal, cytolytic and antimicrobial peptide. Has insecticidal activity against the flesh fly S. carnaria, and against the cockroach N. cinerea. CIT 1a Has hemolytic activity against human erythrocytes, and cytolytic activity against insect Sf9 cells in the same concentration range. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Tissue specificity: Expressed by the venom gland.
Toxic dose: LD50 is 5 ?g/g for adult and 20 ?g/g for larvae of flesh fly S. carnaria. LD50 is 500 ?g/g for cockroach N. cinerea."	"[Ref.18215128]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.5 ?M), Bacillus subtilis VKM B-501 (MIC=0.9 ?M), Micrococcus luteus (MIC>30 ?M), Staphylococcus aureus (MIC>30 ?M);##Gram-negative bacteria: Escherichia coli C600 (MIC=0.5 ?M), E. coli DH5alpha (MIC=0.9 ?M), E. coli MH1 (MIC=0.5 ?M), Pseudomonas aeruginosa PAO1 (MIC=1.9 ?M), Pseudomonas fluorescens VKM B-894 (MIC=3.8 ?M)."	[Ref.18215128]EC50=6 ¦ÌM against human erythrocytes 	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18215128	Biochem J. 2008 May 1;411(3):687-696.	"Vassilevski A.A, Kozlov S.A, Samsonova O.V, Egorova N.S, Karpunin D.V, Pluzhnikov K.A, Feofanov A.V, Grishin E.V."	"Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom."
DRAMP03253	GKLQAFLAKMKEIAAQTL	18	"M-lycotoxin-Ls3a (M-LCTX-Ls3a; Lycocitin-1; spiders, Arthropods, animals)"	P0C2U6	Not found	Not found	Lycosa singoriensis (Wolf spider) (Aranea singoriensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Inhibits growth of Gram-positive and Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation."	"Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis ATCC6633 (MIC=1.6-3.2 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=3.2-6.4 ?M), Pseudomonas aeruginosa.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14991689	J Mass Spectrom. 2004 Feb;39(2):193-201.	"Budnik BA, Olsen JV, Egorov TA, Anisimova VE, Galkina TG, Musolyamov AK, Grishin EV, Zubarev RA."	De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis.
DRAMP03254	GRLQAFLAKMKEIAAQTL	18	"M-lycotoxin-Ls3b (M-LCTX-Ls3b; Lycocitin-2; spiders, Arthropods, animals)"	P0C2U7	Not found	Not found	Lycosa singoriensis (Wolf spider) (Aranea singoriensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Inhibits growth of Gram-positive and Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation."	"Gram-positive bacteria: Staphylococcus aureus 209P, Bacillus subtilis ATCC 6633 (MIC=1.57-3.14 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=3.14-6.29 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=5.02-10.05 ?M).##Fungi: Candida albicans. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14991689	J Mass Spectrom. 2004 Feb;39(2):193-201.	"Budnik BA, Olsen JV, Egorov TA, Anisimova VE, Galkina TG, Musolyamov AK, Grishin EV, Zubarev RA."	De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis.
DRAMP03278	IWLTALKFLGKHAAKHLAKQQLSKL	25	"M-lycotoxin-Hc1a (M-LCTX-Hc1a; Lycotoxin I; spiders, Arthropods, animals)"	P61507	Not found	Not found	Hogna carolinensis (Carolina wolf spider) (Lycosa carolinensis) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. Is lethal to lepidopteran larvae. May Function: both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion."	"Gram-positive bacteria: Bacillus thuringiensis subsp. Israelensis (MIC<5.0 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC=10-20 ?M), Escherichia coli DH5 (MIC=80-150 ?M).##Fungi: Candida glabrata ATCC 2001 (MIC=100-150 ?M), Candida albicans clinical isolate (MIC=100-200 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	9442044##18098329 	J Biol Chem. 1998 Jan 23;273(4):2059-2066.##J Pept Sci. 2008 Apr;14(4):528-534.	"Yan L, Adams ME.##Ad?o R, Seixas R, Gomes P, Pessoa JC, Bastos M."	"Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.##Membrane structure and interactions of a short Lycotoxin I analogue."
DRAMP03279	KIKWFKTMKSIAKFIAKEQMKKHLGGE	27	"M-lycotoxin-Hc2a (M-LCTX-Hc2a; Lycotoxin-2; Lycotoxin II; spiders, Arthropods, animals)"	P61508	Not found	Not found	Hogna carolinensis (Carolina wolf spider) (Lycosa carolinensis) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. May Function: both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion."	"Gram-positive bacteria: Bacillus thuringiensis subsp. Israelensis (MIC=10-60 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC<10 ?M), Escherichia coli DH5 (MIC<40 ?M).##Fungi: Candida glabrata ATCC 2001 (MIC=100-150 ?M)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	9442044##18098329	J Biol Chem. 1998 Jan 23;273(4):2059-2066.##J Pept Sci. 2008 Apr;14(4):528-534.	"Yan L, Adams ME.##Ad?o R, Seixas R, Gomes P, Pessoa JC, Bastos M."	"Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.##Membrane structure and interactions of a short Lycotoxin I analogue."
DRAMP03280	ATYDGKCYKKDNICKYKAQSGKTAICKCYVKVCPRDGAKCEFDSYKGKCYC	51	AcAMP (A. clavatus antimicrobial peptide)	No entry found	Not found	Not found	Aspergillus clavatus ES1	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal"	Not found	Not found	Not found	None	"This basic, Cys-rich antifungal peptide is also active against bacteria. AcAMP was sensitive to proteolytic enzymes, stable between pH 5.0 and 10.0, and heat resistant (15 min at 100 degrees C). "	"Gram-positive bacteria: Staphylococcus aureus (MIC=20 ?g/ml), Bacillus cereus (MIC=10 ?g/ml), Micrococcus luteus (MIC=10 ?g/ml), Enterococcus faecalis (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=30 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml).##Fungi: Aspergillus niger, Fusarium solani, Fusarium oxysporum."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20440534	J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-813.	"Hajji M, Jellouli K, Hmidet N, Balti R, Sellami-Kamoun A, Nasri M."	A highly thermostable antimicrobial peptide from Aspergillus clavatus ES1: biochemical and molecular characterization.
DRAMP03285	LFCRKGTCHFGGCPAHLVKVGSCFGFRACCKWPWDV	36	"Ostricacin-1 (Beta-defensin 2; Birds, animals)"	P85113	Belongs to the beta-defensin family	Not found	Struthio camelus (Ostrich)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	PTM: Contains three disulfide bonds 3-29; 8-23; 13-30.	"Gram-positive bacteria: Staphylococcus aureus 1056-MRSA (MIC=1.25 ?g/ml), S. aureus NCTC 4163 (MIC=6.7 ?g/ml);##Gram-negative bacteria: Escherichia coli O157:H7 (MIC=0.96 ?g/ml), E. coli 0111 (MIC=6.7 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys3 and Cys29,Cys8 and Cys23,Cys13 and Cys30."	L	No cytotoxicity information found	Not found	16459058	Biotechnol Lett 2001; 23: 207-210.##Int J Antimicrob Agents. 2006 Mar;27(3):229-235.	"Yu, PL, Choudhury SD, Ahrens K.##Sugiarto H, Yu PL."	"Purification and characterization of the antimicrobial peptide, ostricacin.##Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins."
DRAMP03286	APGNKAECEREKGYCGFLKCSFPFVVSGKCSRFFFCCKNIW	41	"Ostricacin-2 (Beta-defensin 1; Birds, animals)"	P85114	Belongs to the beta-defensin family	Not found	Struthio camelus (Ostrich)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	PTM: Contains three disulfide bonds 8-36; 15-30; 20-37.	Gram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=1.25 ?g/ml);##Gram-negative bacterium: Escherichia coli O157:H7 (MIC=0.96 ?g/ml);##Yeast: Candida albicans 3153A (MIC=6.2 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys8 and Cys36,Cys15 and Cys30,Cys20 and Cys37."	L	No cytotoxicity information found	Not found	16459058	Int J Antimicrob Agents. 2006 Mar;27(3):229-235.	"Sugiarto H, Yu PL."	Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins.
DRAMP03287	IPRPLDPCIAQNGRCFTGICRYPYFWIGTCRNGKSCCRRR	40	"Ostricacin-3 (Beta-defensin 7; Birds, animals)"	P85115	Belongs to the beta-defensin family	Not found	Struthio camelus (Ostrich)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	PTM: Contains three disulfide bonds 8-36; 15-30; 20-37.	Gram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=2.78 ?g/ml);##Gram-negative bacterium: Escherichia coli O157:H7 (MIC=2.41 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys8 and Cys36,Cys15 and Cys30,Cys20 and Cys37."	L	No cytotoxicity information found	Not found	16459058	Int J Antimicrob Agents. 2006 Mar;27(3):229-235.	"Sugiarto H, Yu PL."	Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins.
DRAMP03288	LPVNEAQCRQVGGYCGLRICNFPSRFLGLCTRNHPCCSRVWV	42	"Ostricacin-4 (Beta-defensin 8; Birds, animals)"	P85116	Belongs to the beta-defensin family	Not found	Struthio camelus (Ostrich)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	PTM: Contains three disulfide bonds 8-36; 15-30; 20-37.	Gram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=11.48 ?g/ml);##Gram-negative bacterium: Escherichia coli O157:H7 (MIC=12.03 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys8 and Cys36,Cys15 and Cys30,Cys20 and Cys37."	L	No cytotoxicity information found	Not found	16459058	Int J Antimicrob Agents. 2006 Mar;27(3):229-235.	"Sugiarto H, Yu PL."	Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins.
DRAMP03311	RGFRKHFNKLVKKVKHTISETAHVAKDTAVIAGSGAAVVAAT	42	"Stomoxyn (Insects, animals)"	Q8T9R8	Not found	Not found	Stomoxys calcitrans (Stable fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix (4 helices; 32 residues)	"Stomoxyn adoptS a flexible random coil structure in water while both assume a stable helical structure in the presence of TFE. In 50% TFE, the structure of stomoxyn is typical of cecropins, including an amphipathic helix at the N-terminus and a hydrophobic C-terminus with helical features that probably fold in a helical conformation at higher TFE concentration. (Ref.2)"	1ZRX resolved by NMR.	"Function: Has antimicrobial activity against most Gram-positive and Gram-negative bacteria, filamentous fungi and yeasts tested. Has trypanolytic effect on T.b.rhodesiense and hemolytic activity against bovine red blood cells. May play an important role in protecting the stored blood in the anterior midgut from microorganisms prior to digestion. Adopts an amphipathic alpha-helical structure only in the presence of an organic solvent that mimics a phospholipid membrane.
Tissue specificity: Constitutively expressed in the adult anterior midgut; proventriculus, thoracic and reservoir regions."	"[Ref.12372834]Gram-negative bacteria: Escherichia coli K12 RM148 (MIC=0.19-0.39 ?M), E. coli D22 (MIC=0.19-0.39 ?M), E. coli D31(MIC=0.19-0.39 ?M), E. coli SBS363 (MIC<0.19 ?M), E. coli 1106 (MIC=0.19-0.39 ?M), Enterobacter cloacae b12 (MIC=3.12-6.25 ?M), Erwinia carotovora (MIC=0.78-1.56 ?M), Klebsiella pneumoniae (MIC=0.78-1.56 ?M), Pseudomonas aeruginosa (MIC=0.39-0.78 ?M), Salmonella typhimurium (MIC=0.39-0.78 ?M), Xanthomonas campestris ( MIC=0.39-0.78 ?M);##Gram-positive bacteria: Aerococcus viridans (MIC=0.78-1.56 ?M), Bacillus megaterium (MIC=0.78-1.56 ?M), Bacillus subtilis (MIC=6.25-12.5 ?M), Enterococcus faecalis (MIC=0.78-1.56 ?M), Micrococcus luteus (MIC=0.78-1.56 ?M), Streptococcus pyogenes (MIC=1.56-3.12 ?M);##Fungi: Aspergillus fumigatus (MIC=50-100 ?M), Fusarium culmorum (MIC=0.39-0.78 ?M), Fusarium oxysporum (MIC=0.78-1.56 ?M), Nectria haematococca (MIC=0.39-0.78 ?M), N. crassa (MIC=3.12-6.25 ?M), Trichoderma viride (MIC=1.56-3.12 ?M), Trichophyton mentagrophytes (MIC=3.12-6.25 ?M), Candida albicans (MIC=25-50 ?M), C. glabrata (MIC=25-50 ?M), C. neoformans (MIC=0.78-1.56 ?M)."	"[Ref.12372834]2% hemolytic activity at 10 ¦ÌM, 9% hemolytic activity at 100 ¦ÌM against bovine red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12372834##16170803	J. Biol. Chem. 2002; 277: 49921-49926.##Biopolymers. 2006 Feb 5;81(2):92-103.	"Nathalie Boulanger, Rebecca J. L. Munks, Joanne V. Hamilton, Fran?oise Vovelle, Reto Brun, Mike J. Lehane, and Philippe Bulet.##Landon C, Meudal H, Boulanger N, Bulet P, Vovelle F."	"Epithelial innate immunity. A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans.##Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation."
DRAMP03312	VDKPDYRPRPRPPNM	15	"Metalnikowin-1 (Metalnikowin I; Insects, animals)"	P80408	Not found	Not found	Palomena prasina (Green shield bug) (Cimex prasinus)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Rich	Not found	None	"Function: Antibacterial peptide active against Gram-negative bacteria.
Induction: By bacterial infection."	"Gram-negative bacteria: Escherichia coli D22 (MIC=50-100 ?M), Salmonella typhimurium (MIC=50-100 ?M), Alcaligenes faecalis (MIC=50-100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	J. Insect Physiol. 1996; 42: 81-89.	"Chernysh S, Cociancich S, Briand JP, Hetru C, Bulet P."	The inducible antibacterial peptides of the hemipteran insect Palomena prasina: identification of a unique family of proline-rich peptides and of a novel insect defensin.
DRAMP03370	QLINSPVTCMSYGGSCQRSCNGGFRLGGHCGHPKIRCCRRK	41	"Beta-defensin 6 (BD-6, mBD-6; Defensin, beta 6; Rodents, mammals, animals)"	Q91VD6	Belongs to the beta-defensin family	Defb6	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Bridge	Not found	None	"PTM: Contains three disulfide bonds 9-37; 16-30; 20-38.
Predominantly expressed in skeletal muscle, also expressed in esophagus, tongue, and trachea. Also expressed in lung when induced by lipopolysaccharide. Expressed constitutively and induced by lipopolysaccharide (LPS)."	Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=20 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys9 and Cys37,Cys16 and Cys30,Cys20 and Cys38."	L	No cytotoxicity information found	Not found	11408484	J Biol Chem. 2001 Aug 24;276(34):31510-31514.	"Yamaguchi Y, Fukuhara S, Nagase T, Tomita T, Hitomi S, Kimura S, Kurihara H, Ouchi Y."	"A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle."
DRAMP03405	GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE	33	"mCRAMP-1 (mouse cathelin-related antimicrobial peptide 1; cathelicidin; Rodents, mammals, animals"	"P51437, Q0VB78"	Not found	Camp	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Alpha helix (CD)	The spectra of 10-25 ?m synthetic CRAMP-1 in buffer suggest that the peptide is in a random coil configuration and that it will assume a helical structure in the presence of 15¨C45% (v/v) trifluoroethanol.	None	"Function: Acts as a potent antimicrobial peptide.
Tissue specificity: Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver."	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=2 ?M), Escherichia coli D21 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan I (MIC=32 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus aureus (MRSA) (MIC=64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=16 ?M), Streptococcus faecalis ATCC 29212 (MIC=16 ?M), Bacillus megaterium Bm11 (MIC=4 ?M).##Fungi: Candida albicans (MIC>64 ?M), Cryptococcus neoformans (MIC=16 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9148921##8706928	J Biol Chem. 1997 May 16;272(20):13088-13093.##FEBS Lett. 1996 Aug 5;391(1-2):5-8.	"Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R.##Popsueva AE, Zinovjeva MV, Visser JW, Zijlmans JM, Fibbe WE, Belyavsky AV."	"Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse.##A novel murine cathelin-like protein expressed in bone marrow."
DRAMP03406	ISRLAGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE	38	"mCRAMP-2 (mouse cathelin-related antimicrobial peptide 2; cathelicidin; Rodents, mammals, animals"	"P51437, Q0VB78"	Not found	Camp	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Alpha helix (CD)	The CD spectra of CRAMP-2 (not shown) were similar to CRAMP-1.	None	"Function: Acts as a potent antimicrobial peptide.
Tissue specificity: Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver."	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=2 ?M), Escherichia coli D21 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan I (MIC=32 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus aureus (MRSA) (MIC=64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=16 ?M), Streptococcus faecalis ATCC 29212 (MIC=32 ?M), Bacillus megaterium Bm11 (MIC=4 ?M).##Fungi: Candida albicans (MIC>64 ?M), Cryptococcus neoformans (MIC=16 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9148921##8706928	J Biol Chem. 1997 May 16;272(20):13088-13093.##FEBS Lett. 1996 Aug 5;391(1-2):5-8.	"Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R.##Popsueva AE, Zinovjeva MV, Visser JW, Zijlmans JM, Fibbe WE, Belyavsky AV."	"Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse.##A novel murine cathelin-like protein expressed in bone marrow."
DRAMP03419	VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR	32	"Neutrophil antibiotic peptide NP-1 (RatNP-1; Rodents, mammals, animals)"	Q62716	Belongs to the alpha-defensin family	Not found	Rattus norvegicus (Rat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Comment: Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus."	"Gram-positive bacterium: Staphylococcus aureus 502A [18 h] (MIC<100 cfu/ml);##Gram-negative bacterium: Escherichia coli ML-35 [18 h] (MIC<100 cfu/ml).##Fungi: Candida albicans 820 [18 h] (MIC<100 cfu/ml), Cryptococcus neoformans A-383 [18 h] (MIC=1.7 x 102 cfu/ml). "	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30."	L	No cytotoxicity information found	Not found	2543629##7594610	Infect. Immun. 1989;57:2021-2027.##J. Immunol. 1995;155:4476-4484.	"Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Selsted M.E, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E."	Purification and antimicrobial properties of three defensins from rat neutrophils.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis.
DRAMP03422	ACYCRIGACVSGERLTGACGLNGRIYRLCCR	31	"Neutrophil antibiotic peptide NP-4 (RatNP-4; Rodents, mammals, animals)"	Q62714	Belongs to the alpha-defensin family	Np4	Rattus norvegicus (Rat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal"	Protein level	Bridge	Not found	None	"Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus."	"Gram-positive bacterium: Staphylococcus aureus 502A (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35, Acinetobacter calcoaceticus (MIC=50 ?g/ml).Fungi: Cryptococcus neoformans (MIC=10 ?g/ml), Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29."	L	No cytotoxicity information found	Not found	2543629##7594610	Infect. Immun. 1989;57:2021-2027.##J. Immunol. 1995;155:4476-4484.	"Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Selsted M.E, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E."	Purification and antimicrobial properties of three defensins from rat neutrophils.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis.
DRAMP03464	GLLNGLALRLGKRALKKIIKRLCR	24	"Cryptonin (Insects, animals)"	P85028	Not found	Not found	Cryptotympana dubia (Korean horse cicada)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	Function: Has very low hemolytic activity on rat erythrocytes. 	"[Ref.18000874]Gram-positive bacteria: Bacillus subtilis KCTC 3086 (MIC=3.12 ?g/ml), Staphylococcus aureus KCTC 1928 (MIC=25 ?g/ml), Micrococcus luteus KCTC 3063 (MIC=1.56 ?g/ml), Staphylococcus aureus (MRSA) (MIC=25 ?g/ml), VRE (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli K12-594 (MIC=3.12 ?g/ml);##Fungi: Candida albicans KCTC 7965 (MIC=50 ?g/ml), Candida tropicalis KCTC 1925 (MIC=3.12 ?g/ml)."	[Ref.18000874]<5% hemolytic activity at 25-200 ?g/ml against rat erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18000874	Arch Insect Biochem Physiol. 2007 Dec;66(4):204-213.	"Leem JY, Park DS, Suh EY, Hur JH, Oh HW, Park HY."	"Isolation and functional analysis of a 24-residue linear alpha-helical antimicrobial peptide from Korean blackish cicada, Cryptotympana dubia (Homoptera)."
DRAMP03467	PAQPFRFPKHPQGPQTRPPI	20	Antibacterial napin (Plants)	P84529	Belongs to the 2S seed storage albumins family	Not found	Brassica rapa subsp. chinensis (Pak-choi)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: The small, basic, water-soluble napins are one of the two major kinds of storage proteins synthesized in the seed during its maturation. Inhibits cell-free protein synthesis. Has antibacterial activity against Gram-negative bacterium P. fluorescens, and the Gram-positive bacteria B. subtilis, B. cereus, B. megaterium and M. phei. No antibacterial activity against the Gram-positive bacterium S. aureus or the Gram-negative bacteria E. coli, E. aerogenes and P. aeruginosa.
Subunit structure: The mature protein consists of a small and a large chain linked by disulfide bonds."	"Gram-negative bacterium: Pseudomonas fluorescens (MIC=66¡À3.7 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=236¡À10.2 ?M), Bacillus cereus (MIC=222¡À9.1 ?M), Bacillus megaterium (MIC=215¡À6.8 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15062997	Peptides. 2004 Feb;25(2):171-176.	"Ngai PH, Ng TB."	"A napin-like polypeptide from dwarf Chinese white cabbage seeds with translation-inhibitory, trypsin-inhibitory, and antibacterial activities."
DRAMP03471	GFGCPGNQLKCNNHCKSISCRAGYCDAATLWLRCTCTDCNGKK	43	"Recombinant Crassostrea Gigas Defensin (Cg-Def; molluscs, animals)"	Q4GWV4	Not found	def	Crassostrea gigas (Pacific oyster)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Combine helix and strand structure	Not found	2B68 resolved by NMR.	Function: Has antibacterial activity (By similarity).	"Gram-positive bacteria: Micrococcus lysodeikticus (MIC=0.005-0.01 ?M), Staphylococcus aureus (MIC=1.25-2.5 ?M), Microbacterium maritypicum (MIC=0.5-1 ?M), Bacillus megaterium (MIC>20 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC=35-20 ?M), Vibrio alginolyticus (MIC>20 ?M), Salmonella typhimurium (MIC>20 ?M).##Fungi: Fusarium oxysporum (MIC=9-4.5 ?M), Botrytis cinerea (MIC>20 ?M), Penicillium crustosum (MIC>20 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipid II	16246846	J Biol Chem. 2006 Jan 6;281(1):313-323.	"Gueguen Y, Herpin A, Aumelas A, Garnier J, Fievet J, Escoubas JM, Bulet P, Gonzalez M, Lelong C, Favrel P, Bach¨¨re E."	"Characterization of a defensin from the oyster Crassostrea gigas. Recombinant production, folding, solution structure, antimicrobial activities, and gene expression."
DRAMP03472	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR	74	cgUbiquitin	No entry found	Not found	Not found	Crassostrea gigas (Pacific oyster)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Combine helix and strand structure	"According to the homology modeling, this peptide is composed of three secondary structural motifs including three ¦Á-helices and four ¦Â-strands separated by 7 loops regions."	None	"Function: cgUbiquitin shows broad potent antimicrobial activity against Gram-positive and -negative bacteria, without hemolytic activity."	"[Ref.22858580]Gram-positive bacteria: B. subtilis KCTC1021 (MIC=0.4 ?M), S. aureus RM4220 (MIC=4.7 ?M), S. iniae FP5229 (MIC=0.9 ?M);##Gram-negative bacteria: E. coli D31 (MIC=0.2 ?M), E. coli ML35p (MIC=1.4 ?M), P. aeruginosa KCTC2004 (MIC=0.6 ?M), S. flexneri KCTC2517 (MIC=0.7 ?M), S. sonnei KCTC2009 (MIC=1.2 ?M), A. hydrophila KCTC2358 (MIC=0.7 ?M), V. parahemolyticus KCCM41664 (MIC=1.1 ?M);##Yeast: C. albicans KCTC7965 (MIC=9.4 ?M)."	[Ref.22858580]Non-hemolytic against human red blood cells up to 100 ¦Ìg/mL	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22858580	Mol Immunol. 2013 Jan;53(1-2):88-98.	"Seo JK, Lee MJ, Go HJ, Kim GD, Jeong HD, Nam BH, Park NG."	"Purification and antimicrobial function of ubiquitin isolated from the gill of Pacific oyster, Crassostrea gigas."
DRAMP03486	GKIPVKAIKQAGKVIGKGLRAINIAGTTHDVVSFFRPKKKKH	42	"Manduca Sexta Moricin (MS moricin; Insects, animals)"	Q86MA1	Not found	Not found	Manduca sexta (Tobacco hornworm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix (1 helices; 31 residues)	The tertiary structure is composed of an eight-turn alpha-helix spanning almost the entire peptide. Insights of relationships between the structure and function are also presented. (Ref.1)	2JR8 resolved by NMR.	"Function: Exhibits potent antimicrobial activities against a broad spectrum of Gram-positive and Gram-negative bacteria with a minimum inhibitory concentration of 1.4 microM.
Tissue specificity: expressed in Manduca sexta fat body."	"Gram-negative bacteria: Klebsiella pneumoniae (MIC=6.25 ?g/ml), Salmonella typhimurium (MIC=6.25 ?g/ml), S. typhimurium DT104 (MIC=6.25 ?g/ml), Escherichia coli O157:H7 (MIC=6.25 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25 923 (MIC=6.25 ?g/ml), Methicillin-resistant S. aureus ATCC 43 300 (MIC=6.25 ?g/ml), Methicillin-resistant S. aureus ATCC BAA-39 (MIC=12.5 ?g/ml), Listeria monocytogenes (MIC=6.25 ?g/ml).##NOTE: MIC is de??�ned as the lowest peptide concentration that gives no visible growth after overnight incubation in 100% Muller-Hinton broth."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18265434##12706633	J Pept Sci. 2008 Jul;14(7):855-863.##Insect Biochem Mol Biol. 2003 May;33(5):541-59.	"Dai H, Rayaprolu S, Gong Y, Huang R, Prakash O, Jiang H.##Zhu Y, Johnson TJ, Myers AA, Kanost MR."	"Solution structure, antibacterial activity, and expression profile of Manduca sexta moricin.##Identification by subtractive suppression hybridization of bacteria-induced genes expressed in Manduca sexta fat body."
DRAMP03507	KWKIFKKIEKVGRNIRNGIIKAGPAVAVLGEAKAL	35	"Cecropin-B (Insects, animals)"	P01509	Belongs to the cecropin family	Not found	Antheraea pernyi (Chinese oak silkmoth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.36 ?M), Escherichia coli D31 (MIC=0.30 ?M), Serratia marsescens (MIC=2.6 ?M), Serratia marsescens Strain 122 (MIC=12 ?M), Pseudomonas aeruginosa OT97 (MIC=2.9 ?M), Xenorhabdus nematophilus Xn21 (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis Bsll (MIC=17 ?M), Bacillus megaterium Bmll (MIC=0.64 ?M), Bacillus thuringiensis Btll (MIC>88 ?M), Streptococcus fecalis Ds16 (MIC>88 ?M), Streptococcus fecalis AD-4 (MIC>88 ?M), Micrococcus luteus MI11 (MIC=0.29 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	6754375##2962676	Eur J Biochem. 1982 Sep;127(1):219-224.##Biomed Environ Mass Spectrom. 1987 Nov;14(11):669-673.	"Qu Z, Steiner H, Engstr?m A, Bennich H, Boman HG.##Craig AG, Engstr?m A, Bennich H, Kamensky I."	"Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi.##Plasma desorption mass spectrometry coupled with conventional peptide sequencing techniques."
DRAMP03513	KVNVNAIKKGGKAIGKGFKVISAASTAHDVYEHIKNRRH	39	"G. mellonella moricin-like peptide A (Gm-mlpA; Insects, animals; Predicted)"	A5JSU5	Not found	mor	Galleria mellonella (Greater wax moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=10 ?M).##Fungi: Fusarium graminearum mycelia (MIC=70 ?M), F;##Graminearum spores (MIC=0.7 ?M), Fusarium oxysporum mycelia (MIC=7 ?M), F. oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=7 ?M), Leptosphaeria maculans spores (MIC=7 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18207081	Insect Biochem Mol Biol. 2008;38:201-212.	"Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD."	The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.
DRAMP03514	GKIPVKAIKKGGQIIGKALRGINIASTAHDIISQFKPKKKKNH	43	"G. mellonella moricin-like peptide B (Gm-mlpB; Insects, animals; Predicted)"	A5JSU6	Not found	mor	Galleria mellonella (Greater wax moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), F;##Graminearum mycelia (MIC=280 ?M), Fusarium oxysporum spores (MIC=100 ?M), F. oxysporum mycelia (MIC=280 ?M), Leptosphaeria maculans spores (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18207081	Insect Biochem Mol Biol. 2008;38:201-212.	"Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD."	The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.
DRAMP03515	KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRH	38	"Moricin-like peptide C1 (Gm-mlpC1; Insects, animals; Predicted)"	A5JSU7	Not found	mor	Galleria mellonella (Greater wax moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=1 ?M), Fusarium oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=100 ?M), Leptosphaeria maculans spores (MIC=6 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18207081	Insect Biochem Mol Biol. 2008;38:201-212.	"Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD."	The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.
DRAMP03516	KVPIGAIKKGGKIIKKGLGVLGAAGTAHEVYNHVRNRQ	38	"Moricin-like peptide C2 (Gm-mlpC2; Insects, animals; Predicted)"	A5JSU8	Not found	mor	Galleria mellonella (Greater wax moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=1 ?M), Fusarium oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=100 ?M), Leptosphaeria maculans spores (MIC=8 ?M), Fusarium graminearum mycelia (MIC=8 ?M), Fusarium oxysporum mycelia (MIC=8 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18207081	Insect Biochem Mol Biol. 2008;38:201-212.	"Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD."	The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.
DRAMP03517	KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRQ	38	"Moricin-like peptide C3 (Gm-mlpC3; Insects, animals; Predicted)"	A5JSU9	Not found	mor	Galleria mellonella (Greater wax moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), Fusarium oxysporum spores (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18207081	Insect Biochem Mol Biol. 2008;38:201-212.	"Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD."	The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.
DRAMP03518	KVPVGAIKKGGKAIKTGLGVVGAAGTAHEVYSHIRNRH	38	"Moricin-like peptide C4/C5 (Gm-mlpC4/C5; Insects, animals; Predicted)"	A5JSV1	Not found	mor	Galleria mellonella (Greater wax moth)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18207081	Insect Biochem Mol Biol. 2008;38:201-212.	"Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD."	The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.
DRAMP03519	KGIGSALKKGGKIIKGGLGALGAIGTGQQVYEHVQNRQ	38	"Moricin-like peptide D (Gm-mlpD; Insects, animals; Predicted)"	A5JSV2	Not found	mor	Galleria mellonella (Greater wax moth)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=10 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), Fusarium oxysporum spores (MIC=100 ?M), Ascochyta rabiei spores(MIC=100 ?M), Leptosphaeria maculans spores (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18207081	Insect Biochem Mol Biol. 2008;38:201-212.	"Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD."	The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.
DRAMP03532	AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH	42	"Moricin-1 (Insects, animals)"	P82818	Belongs to the moricin family	MOR1	Bombyx mori (Silk moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix (1 helices; 30 residues)	"The solution structure reveals an unique structure comprising of a long alpha-helix containing eight turns along nearly the full length of the peptide except for four N-terminal residues and six C-terminal residues. The electrostatic surface map shows that the N-terminal segment of the alpha-helix, residues 5-22, is an amphipathic alpha-helix with a clear separation of hydrophobic and hydrophilic faces, and that the C-terminal segment o"	1KV4 resolved by NMR.	Function: Has antibacterial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.	"Gram-negative bacteria: Escherichia coli JM109 (MIC=0.31 ?M), Acinetobacter sp. NISL B-4653 (MIC=0.27 ?M), Pseudomonas fluorescens IAM1179 (MIC=0.53 ?M), Pseudomonas aeruginosa IAM15140 (MIC=0.81 ?M);##Gram-positive bacteria: Bacillus subtilis IAM1107 (MIC=0.19 ?M), Bacillus megaterium IAM1030 (MI=0.09 ?M), Bacillus cereus IFO3457 (MIC=0.38 ?M), Staphylococcus aureus ATCC6538P (MIC=0.21 ?M), Staphylococcus aureus ATCC6538P (MIC=0.22 ?M), Staphylococcus aureus IFO3083 (MIC=0.46 ?M), Staphylococcus xylosus IAM1312 (MIC=0.27 ?M), Staphylococcus epidermidis IFO12993 (MIC=0.18 ?M), Streptococcus pyogenes ATCC21547 (MIC=0.25 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8530391##11997013	J Biol Chem. 1995 Dec 15;270(50):29923-29927.##FEBS Lett. 2002 May 8;518(1-3):33-38.	"Hara S, Yamakawa M.##Hemmi H, Ishibashi J, Hara S, Yamakawa M."	"Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori.##Solution structure of moricin, an antibacterial peptide, isolated from the silkworm Bombyx mori."
DRAMP03567	KRIVQRIKDFLRNLVPRTES	20	KR-20 (Derived from LL-37)	No entry found	Not found	Not found	Homo sapiens (Human sweat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix 	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus mprF (MIC=16 ?M), Staphylococcus aureus ATCC 25923 (MIC>64 ?M), Staphylococcus aureus (GAS) (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC>64 ?M).##Yeast: Candida albicans ATCC 14053 (MIC=10 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	14978112	J Immunol 2004; 172: 3070-3077.	"Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL."	Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense.
DRAMP03568	RKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	31	RK-31 (Derived from LL-37)	No entry found	Not found	Not found	Homo sapiens (Human sweat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix 	Not found	None	Function: Has hemolytic activity against human erythrocytes .	"[Ref.14978112]Gram-positive bacteria: Staphylococcus aureus mprF (MIC=8 ?M), Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Group A Staphylococcus aureus (GAS) (MIC=8 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC=8 ?M);##Yeast: Candida albicans ATCC 14053 (MIC=4 ?M)."	[Ref.14978112]6% hemolytic activity at 44 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	14978112	J Immunol 2004; 172: 3070-3077.	"Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL."	Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense.
DRAMP03569	KSKEKIGKEFKRIVQRIKDFLRNLVPRTES	30	KS-30 (Derived from LL-37)	No entry found	Not found	Not found	Homo sapiens (Human sweat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix 	Not found	None	Function:Has hemolytic activity against human erythrocytes.	"[Ref.14978112]Gram-positive bacteria: Staphylococcus aureus mprF (MIC=8 ?M), Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Group A Staphylococcus aureus (GAS) (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC=8 ?M);##Yeast: Candida albicans ATCC 14053 (MIC=2 ?M)"	[Ref.14978112]23% hemolytic activity at 88 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	14978112	J Immunol 2004; 172: 3070-3077.	"Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL."	Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense.
DRAMP03570	LLGDFFRKSKEKIGKEFKRIVQR	23	LL-23 (Derived from LL-37)	"P49913, Q71SN9"	Not found	Not found	Homo sapiens (Human sweat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix (1 helices; 19 residues)	"The Ser9 site splits the hydrophobic surface of the amphipathic helix into two domains, which explains its poor antimicrobial activity (active against only susceptible bacterial strains). "	2LMF resolved by NMR.	"Its structure, dynamics, and antimicrobial and immune modulating activities have been characterized (Biochemistry 2012)."	"Gram-negative bacterium: Escherichia coli DC2 (MIC=9 ?M);##Gram-positive bacteria: Staphylococcus aureus mprF (presence of carbonate) (MIC=3 ?M), S. aureu mprF (absence of carbonate) (MIC=24 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17012259##22185690	"FASEB J 2006; 20, 2068-2080.##Biochemistry. 2012 Jan 17;51(2):653-664. "	"Yamasaki K et al. Gallo RL.##Wang G, Elliott M, Cogen AL, Ezell EL, Gallo RL, Hancock RE."	"Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin.##Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins."
DRAMP01877	GLMSVLKGVLKTAGKHIFKNVGGSLLDQAKCKITGQC	37	"Brevinin-2PRd (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana pirica (Hokkaido frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: activity against reference strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae) and Gram-positive (Staphlococcus aureus) bacteria but displayed relatively low hemolytic activity. "	"[Ref.15003829] Gram-negative bacterium: Escherichia coli(MIC=3¦ÌM), Pseudemonas aeruginosa(MIC=3¦ÌM), Enterobacter cloacae(MIC=6¦ÌM), Klebsiella pneumoniae(MIC=6¦ÌM);## Gram-positive bacterium: Staphylococcus aureus(MIC=25¦ÌM);## Yeast: Candida albicans(MIC=100¦ÌM)"	[Ref.15003829] HC50=100 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	15003829	Regul Pept. 2004 May 15;118(3):135-141.	"Conlon JM, Sonnevend A, Patel M, Al-Dhaheri K, Nielsen PF, Kolodziejek J, Nowotny N, Iwamuro S, P"	"A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica."
DRAMP01878	GLLSVLKGVLKTAGKHIFKNVGGSLLDQAKCKISGQC	37	"Brevinin-2PRe (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana pirica (Hokkaido frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: activity against reference strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae) and Gram-positive (Staphlococcus aureus) bacteria but displayed relatively low hemolytic activity. "	"[Ref.15003829] Gram-negative bacterium: Escherichia coli(MIC=3¦ÌM), Pseudemonas aeruginosa(MIC=3¦ÌM), Enterobacter cloacae(MIC=3¦ÌM), Klebsiella pneumoniae(MIC=6¦ÌM);## Gram-positive bacterium: Staphylococcus aureus(MIC=25¦ÌM);## Yeast: Candida albicans(MIC>100¦ÌM)"	[Ref.15003829] HC50=80 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	15003829	Regul Pept. 2004 May 15;118(3):135-141.	"Conlon JM, Sonnevend A, Patel M, Al-Dhaheri K, Nielsen PF, Kolodziejek J, Nowotny N, Iwamuro S, P"	"A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica."
DRAMP03573	IGKEFKRIVQRIKDFLRNLVPRTES	25	"LL-37(13-37)(C-terminal fragment of LL-37; Human, mammals, animals)"	"P49913, Q71SN9"	Not found	Not found	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram-, Anticancer"	Protein level	Alpha helix (1 helices; 14 residues)	Residues 17-29 of LL-37(13-37) are helical.	2FCG resolved by NMR.	The slightly lower activity of LL-37(13-37) may result from the interference of the disordered regions with membrane binding of the peptide.	"Gram-negative bacterium: Escherichia coli K12 (MIC=80 ?M).##Drug-resistant KBv cancer cells (LC50=39 ?M), Drug-sensitive KB cancer cells (LC50=40 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16637646	J Am Chem Soc. 2006 May 3;128(17):5776-5785.	"Li X, Li Y, Han H, Miller DW, Wang G. "	Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. 
DRAMP03574	FKRIVQRIKDFLRNLV	16	"LL-37(17-32)(C-terminal fragment of LL-37; Human, mammals, animals)"	"P49913, Q71SN9"	Not found	Not found	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram-, Anticancer"	Protein level	Not found	"To achieve selective membrane targeting, D-amino acids were incorporated into LL-37(17-32). The D-peptide showed similar antibacterial activity to the L-diastereomer, it lost toxicity to human cells. "	None	Antibacterial and anticancer assays found that LL-37(17-32) was more active than LL-37(13-37). 	"Gram-negative bacteria: Escherichia coli K12(MIC=20 ?M).##Drug-resistant KBv cancer cells (LC50=30 ?M), Drug-sensitive KB cancer cells (LC50=30 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16637646	J Am Chem Soc. 2006 May 3;128(17):5776-5785.	"Li X, Li Y, Han H, Miller DW, Wang G. "	Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. 
DRAMP03598	GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP	41	"Human beta-defensin 2 (hBD-2; Defensin, beta 2; Beta-defensin 4A; Human, mammals, animals)"	"O15263, Q52LC0"	Belongs to the beta-defensin family	DEFB4A AND DEFB4B	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Protein level	Combine helix and strand structure	The structure (one N-terminal helix and 3 beta strands) was found to be monomer in solution (PDB ID: 1E4Q) but a dimer in the crystal (PDB ID: 1FD3). 	"1FD4, 1FD3 resolved by X-ray.##1FQQ resolved by NMR."	"Function: Has anti-HIV and antibacterial activity.
Tissue specificity: Expressed in the skin and respiratory tract.
Induction: By inflammation.
PTM: Contains three disulfide bonds 8-37, 15-30, 20-38.
Transgenic plants: expression of this peptide in Arabidopsis thaliana reduced fungal infection."	"Gram-negative bacteria: Escherichia coli D31(MIC=62 ?g/ml), Escherichia coli ATCC (MIC=62 ?g/ml), Pseudomonas aeruginosa ATCC (MIC=62 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC (MIC=62 ?g/ml), Enterococcus faecalis ATCC (MIC=15 ?g/ml)."	[Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 ¦Ìg/ml.	Cyclic	Free	Free	"Disulfide bonds between Cys8 and Cys37,Cys15 and Cys30,Cys20 and Cys38."	L	No cytotoxicity information found	Not found	9202117##10906336##17340092	Nature. 1997 Jun 26;387(6636):861.##J Biol Chem. 2000 Oct 20;275(42):32911-32918.##Plant Cell Rep. 2007 Aug;26(8):1391-1398.	"Harder J, Bartels J, Christophers E, Schr?der JM.##Hoover DM, Rajashankar KR, Blumenthal R, Puri A, Oppenheim JJ, Chertov O, Lubkowski J.##Aerts AM, Thevissen K, Bresseleers SM, Sels J, Wouters P, Cammue BP, Fran?ois IE."	A peptide antibiotic from human skin.##The structure of human beta-defensin-2 shows evidence of higher order oligomerization.##Arabidopsis thaliana plants expressing human beta-defensin-2 are more resistant to fungal attack: functional homology between plant and human defensins.
DRAMP03599	GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK	45	"Human beta-defensin 3 (BD-3, hBD-3; Hbd3; Beta-defensin 103; Human, mammals, animals)"	"P81534, Q8NFG6, Q9NPF6"	Belongs to the beta-defensin family	DEFB103A AND DEFB103	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Combine helix and strand structure	Contains three disulfide bonds and a short helical segment preceding a three-stranded antiparallel beta-sheet. 	1KJ6?resolved by NMR.	"Function: Exhibits antimicrobial activity against Gram-positive bacteria and the Gram-negative bacteria and the yeast C.albicans. Kills multiresistant S. aureus and vancomycin-resistant E. faecium. Has hemolytic activity.
Tissue specificity: Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.
Induction: By bacterial infection and by IFNG/IFN-gamma.
PTM: Contains three disulfide bonds 11-40; 18-33; 23-41."	"[Ref.11085990]Gram-negative bacteria: Escherichia coli DSM1103 (MIC=9.4 ?g/ml), Klebsiella pneumoniae DSM681 (MIC=25 ?g/ml), Pseudomonas aeruginosa DSM1128 (MIC=18.75 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.7 ?g/ml), Streptococcus pneumoniae DSM11865 (MIC=4.7 ?g/ml)."	"[Ref.11085990] It has 9% hemolysis at 250 ?g/ml, 15% hemolysis at 500 ?g/ml against human erythrocytes."	Cyclic	Free	Free	"Disulfide bonds between Cys11 and Cys40,Cys18 and Cys33,Cys23 and Cys41."	L	No cytotoxicity information found	Not found	15625724##11085990	Biopolymers. 2005;80(1):34-49.##J Biol Chem. 2001 Feb 23;276(8):5707-5713.	"Schulz A, Kl¨¹ver E, Schulz-Maronde S, Adermann K.##Harder J, Bartels J, Christophers E, Schroder JM."	"Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins.##Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic."
DRAMP03600	EFELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP	50	"Human beta-defensin 4 (hBD-4, BD-4; Beta-defensin 104; Human, mammals, animals)"	"Q8WTQ1, Q496I2, Q496I3, Q496I4"	Belongs to the beta-defensin family	DEFB104A	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Bridge 	Not found	None	"Function: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
Tissue specificity: High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested.
Induction: Antimicrobial activity is decreased when the sodium chloride concentration is increased.
PTM: Contains three disulfide bonds (By similarity)."	"Gram-positive bacterium: Staphylococcus carnosus TM300 (MIC=4.5 ?g/ml);##Gram-negative bacteria: Escherichia coli BL21 (MIC>100 ?g/ml), Pseudomonas aeruginosa (MIC=4.1 ?g/ml).##Yeast: Saccharomyces cerevisiae ATCC9763 (MIC>100 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys8 and Cys36,Cys15 and Cys29,Cys19 and Cys37."	L	No cytotoxicity information found	Not found	11481241	FASEB J. 2001 Aug;15(10):1819-1821.	"Garc¨ªa JR, Krause A, Schulz S, Rodr¨ªguez-Jim¨¦nez FJ, Kl¨¹ver E, Adermann K, Forssmann U, Frimpong-Boateng A, Bals R, Forssmann WG."	Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity.
DRAMP03603	ARLKKCFNKVTGYCRKKCKVGERYEIGCLSGKLCCAN	37	"Human beta-defensin 28 (hBD-28; hBD28; Human, mammals, animals)"	No entry found	Belongs to the beta-defensin family	Not found	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Bridge 	Not found	None	Function: Has antibacterial activity gaginst Gram-positive and the Gram-negative bacteria. 	"Gram-negative bacteria: Escherichia coli DSM1103 (MIC=37.5 ?g/ml), Klebsiella pneumoniae DSM681 (MIC=50 ?g/ml), Pseudomonas aeruginosa DSM1128 (MIC=37.5 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=25 ?g/ml), Streptococcus pneumoniae DSM11865 (MIC=37.5 ?g/ml)."	[Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 ¦Ìg/ml.	Cyclic	Free	Free	"Disulfide bonds between Cys6 and Cys34,Cys14 and Cys28,Cys18 and Cys35"	L	No cytotoxicity information found	Not found	15625724	Biopolymers. 2005;80(1):34-49.	"Schulz A, Kl¨¹ver E, Schulz-Maronde S, Adermann K."	Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins.
DRAMP03638	LCLDQKPEMEPFRKDAQQALEPSRQRRWLHRRCLSGRGFCRAICSIFEEPVRGNIDCYFGYNCCRRMFSHYRTS	74	VpBD (V.philippinarum beta defensin; big defensin)	No entry found	Not found	Not found	Venerupis philippinarum (The manila clam)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: The rVpBD displays broad-spectrum inhibitory activity towards all tested bacteria with the highest activity against Staphyloccocus aureus and Pseudomonas putida.	"Gram-positive bacteria: Staphyloccocus aureus (MIC=1.64-3.28 ?M), Micrococcus luteus (MIC>26.26 ?M), Bacillus sp. (MIC=13.13-26.26 ?M);##Gram-negative bacteria: Vibrio anguillarum (MIC=13.13-26.26 ?M), Entherobacter cloacae (MIC>26.26 ?M), Vibrio ichthyoenteri (MIC=3.28-6.56 ?M), Pseudomonas putida (MIC=1.64-3.28 ?M), Proteus mirabilis (MIC>26.26 ?M), Enterobacter sp. (MIC=13.13-26.26 ?M)"	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys33 and Cys63,Cys40 and Cys57,Cys44 and Cys64."	L	No cytotoxicity information found	Not found	20975988	PLoS One. 2010 Oct 20;5(10):e13480.	"Zhao J, Li C, Chen A, Li L, Su X, Li T."	Molecular characterization of a novel big defensin from clam Venerupis philippinarum.
DRAMP03642	GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIR	39	"Chicken heterophil peptides 1 (Antimicrobial peptide CHP1; Birds, animals)"	P80389	Belongs to the beta-defensin family	Not found	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge 	Not found	None	"Function: Bactericidal activity; inhibits S. aureus and E. coli.
PTM: Contains three disulfide bonds 6-28; 13-34; 18-35."	Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.7 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus (MIC=0.7 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys6 and Cys28,Cys13 and Cys34,Cys18 and Cys35."	L	No cytotoxicity information found	Not found	7964174	J Leukoc Biol. 1994 Nov;56(5):661-665.	"Evans EW, Beach GG, Wunderlich J, Harmon BG."	Isolation of antimicrobial peptides from avian heterophils.
DRAMP01376	GFMDTAKNAAKNVAVTLLDNLKCKITKAC	29	"Odorranain-F1 (OdF1; Frogs, amphibians, animals)"	A6MBL3	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Odorranain-F1 adopts 55% 	None	Function: Odorranain-F1 exhibites antimicrobial activities against the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbiit red cell.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.20 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2.10 ¦Ìg/ml), Bacillus subtilis (MIC=8.40 ¦Ìg/ml).##Yeast: Candida albicans (MIC=1.05 ¦Ìg/ml)."	"[Ref.17272268] RCH=15.4 ¡À 3.5% against rabbit red blood cells at 50 ¦Ìg/ml. RCH, red cell hemolysis."	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01378	GIFGKILGVGKKVLCGLSGVC	21	"Odorranain-H1 (OdH1; Frogs, amphibians, animals)"	A6MBN4	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Odorranain-H1 adopts 50.3 ¦Â-sheet structure in water solution.	None	Function: Odorranain-H1 exhibites antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbit red cell.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=23.60 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=5.90 ¦Ìg/ml), Bacillus subtilis (MIC=5.90 ¦Ìg/ml).##Yeast: Candida albicans (MIC=11.80 ¦Ìg/ml)."	"[Ref.17272268] RCH=21.6 ¡À 7.3% against rabbit red blood cells. RCH, red cell hemolysis."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01386	VIPFVASVAAEMMQHVYCAASKKC	24	"Odorranain-P1a (OdP1a; Brevinin-1HS1; Brevinin-1-OA2; Frogs, amphibians, animals)"	"A6MBQ8, A6MBQ6"	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	Function: Odorranain-P1a exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbit red cell. 	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.50 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.50 ¦Ìg/ml), Bacillus subtilis (MIC=1.75 ¦Ìg/ml).##Yeast: Candida albicans (MIC=1.75 ¦Ìg/ml)."	"[Ref.17272268] RCH=11.2 ¡À 2.9% against rabbit red blood cells. RCH, red cell hemolysis."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP03646	RVKRFWPLVPVAINTVAAGINLYKAIRRK	29	"Cathelicidin-3 (CATH-3; Fowlicidin-3; Birds, animals)"	Q2IAL6	Not found	CATHL3	Gallus gallus (Chicken) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix (1 helices; 9 residues)	NMR spectroscopy reveales that fowlicidin-3 comprises 27 amino-acid residues and adopts a predominantly alpha-helical structure extending from residue 9 to 25 with a slight kink induced by a glycine at position 17..	2HFR resolved by NMR.	"Function: May have antimicrobial activity and play a role in the innate immune response.
Tissue specificity: Detected in bone marrow, liver and lung."	"Gram-negative bacteria: Escherichia coli 25922 (MIC=2 ?M), Salmonella typhimurium 14028 (MIC=2 ?M), S. typhimurium DT104 700408 (MIC=2 ?M), Salmonella enteritidis 13076 (MIC=2 ?M), Klebsiella pneumoniae 13883 (MIC=1 ?M);##Gram-positive bacteria: Listeria monocytogenes 19115 (MIC=2 ?M), Staphylococcus aureus 25923 (MIC=1 ?M), S. aureus (MRSA) 43300 (MIC=1 ?M), S. aureus (MRSA) BAA-39 (MIC=1 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	17827276##16326712##17229147	Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15063-15068.##J Biol Chem. 2006 Feb 3;281(5):2858-2867.##FEBS J. 2007 Jan;274(2):418-428.	"Goitsuka R, Chen CL, Benyon L, Asano Y, Kitamura D, Cooper MD.##Xiao Y, Cai Y, Bommineni YR, Fernando SC, Prakash O, Gilliland SE, Zhang G.##Bommineni YR, Dai H, Gong YX, Soulages JL, Fernando SC, Desilva U, Prakash O, Zhang G."	"Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway.##Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity.##Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities."
DRAMP03647	PIRNWWIRIWEWLNGIRKRLRQRSPFYVRGHLNVTSTPQP	40	"Cathelicidin-B1 (CATH-B1; cathelicidin; Birds, animals)"	"Q5F378, A7M6V2"	Not found	CATHB1	Gallus gallus (Chicken) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=2.5 ?M), Pseudomonas aeruginosa (MIC=0.63 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=1.25 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17827276##15642098	Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15063-15068.##Genome Biol. 2005;6(1):R6.	"Goitsuka R, Chen CL, Benyon L, Asano Y, Kitamura D, Cooper MD.##Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM."	"Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway.##Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
DRAMP03659	LPRDTSRCVGYHGYCIRSKVCPKPFAAFGTCSWRQKTCCVDTTSDFHTCQDKGGHCVSPKIRCLEEQLGLCPLKRWTCCKEI	82	"Gallinacin-11 (Gal-11; Beta-defensin 11; Birds, animals)"	"Q6IV20, A0A1W6, Q09MT4, Q9PS49"	Belongs to the beta-defensin family	GAL11	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Bridge	Not found	None	"Tissue specificity: Detected in outer membrane of the vitelline layer of the egg (at protein level). Expressed in the liver, gall bladder, kidney, testis, ovary and male and female reproductive tracts. Expressed in the ovarian stroma, but not in the ovarian follicles. No expression is detected in bone marrow. PTM: Contains three disulfide bonds 8-38; 15-31; 21-39."	Gram-negative bacterium: Escherichia coli (MIC=50 nM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17244739##1520265	Reproduction. 2007 Jan;133(1):127-133.##Biochem J. 1992 Aug 15;286 (Pt 1):17-22.	"Subedi K, Isobe N, Nishibori M, Yoshimura Y.##Kido S, Morimoto A, Kim F, Doi Y."	"Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus).##Isolation of a novel protein from the outer layer of the vitelline membrane."
DRAMP03676	APRKNVRWCAISLPEWSKCYQWQRRMRKLGAPSITCIRRTS	41	GLFcin (Lactoferrin fragment)	"Q29477, Q29479"	Belongs to the transferrin family	LTF	Capra hircus (Goat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: GLFcin is thermal-stable and with high antibacterial activity.	"Gram-negative bacteria: Escherichia coli (MIC=4.07 ?g/ml), Propioni bacterium acnes (MIC=12.32 ?g/ml), Pseudemonas aeruginosa (MIC=4.07 ?g/ml);##Gram-positive bacteria: Bacillus cereus (MIC=12.32 ?g/ml), Staphylococcus aureus (MIC=4.07 ?g/ml), Listeria monocytogene (MIC=4.07 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19780544	J Agric Food Chem. 2009 Oct 28;57(20):9509-9515.	"Chen GH, Chen WM, Huang GT, Chen YW, Jiang ST."	Expression of recombinant antibacterial lactoferricin-related peptides from Pichia pastoris expression system.
DRAMP03677	SKCYQWQRRMRKLGAPSITCIRRTS	25	GLFcin II (Lactoferrin fragment)	"Q29477, Q29479"	Belongs to the transferrin family	LTF	Capra hircus (Goat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: GLFcin is thermal-stable and with high antibacterial activity.	"Gram-negative bacteria: Escherichia coli (MIC=6.80 ?g/ml), Propioni bacterium acnes (MIC=10.50 ?g/ml), Pseudemonas aeruginosa (MIC=14.50 ?g/ml);##Gram-positive bacteria: Bacillus cereus (MIC=16.00 ?g/ml), Staphylococcus aureus (MIC=6.80 ?g/ml), Listeria monocytogene (MIC=9.92 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19780544	J Agric Food Chem. 2009 Oct 28;57(20):9509-9515.	"Chen GH, Chen WM, Huang GT, Chen YW, Jiang ST."	Expression of recombinant antibacterial lactoferricin-related peptides from Pichia pastoris expression system.
DRAMP03679	RFRPPIRRPPIRPPFNPPFRPPVRPPFRPPFRPPFRPPIGPFP	43	"Cathelicidin-2 (Bactenecin-5, Bac5; ChBac5; ruminant, animals)"	"P82018, Q4JFB9"	Not found	CATHL2	Capra hircus (Goat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=1 ?g/ml), Salmonella typhimurium (MIC=1 ?g/ml), Pseudomonas aeruginosa (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC<2 ?g/ml), Listeria monocytogenes (MIC<2 ?g/ml) and Bacillus subtilis (MIC<2 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10417180	nfect Immun. 1999 Aug;67(8):4106-4111.	"Shamova O, Brogden KA, Zhao C, Nguyen T, Kokryakov VN, Lehrer RI."	Purification and properties of proline-rich antimicrobial peptides from sheep and goat leukocytes.
DRAMP03682	FLPIIAKLLGGLL	13	"Vespid chemotactic peptide 5e (VCP 5e; Insects, animals)"	P0C1M1	Belongs to the MCD family (Crabrolin subfamily)	Not found	Vespa magnifica 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (By similarity)."	[Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml).	[Ref.16330062]Little hemolytic activity up to 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16330062	Toxicon. 2006 Feb;47(2):249-53.	"Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R."	Two families of antimicrobial peptides from wasp (Vespa magnifica) venom.
DRAMP03683	FLIIRRPIVLGLL	13	"Vespid chemotactic peptide 5g (VCP 5g; Insects, animals)"	P0C1M3	Belongs to the MCD family (Crabrolin subfamily)	Not found	Vespa magnifica 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (By similarity)."	[Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=10 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=12.5 ?g/ml).	[Ref.16330062]Little hemolytic activity up to 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16330062	Toxicon. 2006 Feb;47(2):249-53.	"Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R."	Two families of antimicrobial peptides from wasp (Vespa magnifica) venom.
DRAMP03684	FLPIPRPILLGLL	13	"Vespid chemotactic peptide 5f (VCP 5f; Insects, animals)"	P0C1M2	Belongs to the MCD family (Crabrolin subfamily)	Not found	Vespa magnifica 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (By similarity)."	[Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml).	[Ref.16330062]Little hemolytic activity up to 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16330062	Toxicon. 2006 Feb;47(2):249-53. 	"Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R."	Two families of antimicrobial peptides from wasp (Vespa magnifica) venom.
DRAMP03687	FLSLIPSLVGGSISAFK	17	"TsAP-1 (T. serrulatus antimicrobial peptide 1; scorpions, arachnids, invertebrates, animals)"	S6CWV8	Belongs to the?non-disulfide-bridged peptide (NDBP) superfamily.?Short antimicrobial peptide (group 4) family.	Not found	Tityus serrulatus (Brazilian yellow scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Anticancer activity against HI57 and H838."	"[Ref.23770440] Gram-positive bacteria : Staphylococcus aureus(MIC=120 ¦ÌM, MBC>160 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=160 ¦ÌM, MBC>160 ¦ÌM);##Fungi : Candida albicans(MIC=160 ¦ÌM, MBC>160 ¦ÌM)"	"[Ref.23770440] 0% hemolysis at 40 ¦ÌM , 2% hemolysis at 80 ¦ÌM , 5% hemolysis at 120 ¦ÌM , 7% hemolysis at 160 ¦ÌM against horse red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23770440	Biochimie. 2013 Jun 14. doi: 10.1016/j.biochi.2013.06.003.	"Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C."	"Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities."
DRAMP03691	FSFKRLKGFAKKLWNSKLARKIRTKGLKYVKNFAKDMLSEGEEAPPAAEPPVEAPQ	56	"Im-1 (Arthropods, animals)"	P0CF38	Belongs to the scorpion BPP family	Not found	Isometrus maculatus (Lesser brown scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Causes cytolysis by the formation of pores in the membrane. Causes rapid and reversible paralysis in crickets. Has antibacterial activity.
Tissue specificity: Expressed by the venom gland.
Toxic dose: PD50 is 38 mg/kg into the insect A. domestica."	"Gram-negative bacterium: Escherichia coli NBRC 3972 (MIC=0.4-0.8 ?M);##Gram-positive bacteria: Staphylococcus aureus NBRC 13276 (MIC=13-25 ?M), Bacillus subtilis NBRC 3009 (MIC=0.8-1.6 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	20139620	Biosci Biotechnol Biochem. 2010;74(2):364-369. 	"Miyashita M, Sakai A, Matsushita N, Hanai Y, Nakagawa Y, Miyagawa H."	A novel amphipathic linear peptide with both insect toxicity and antimicrobial activity from the venom of the scorpion Isometrus maculatus.
DRAMP03693	KDGYIIEHRGCKYSCFFGTNSWCNTECTLKKGSSGYCAWPACWCYGLPDNVKIFDSNNLKC	61	"Bactridin-1 (Bact1; Bactridine 1; Arthropods, animals)"	P0CF39	Belongs to the long (4 C-C) scorpion toxin superfamily Sodiu	Not found	Tityus discrepans (Venezuelan scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity. Modifies membrane sodium permeability on Y.enterocolitica. Is toxic to cockroaches and crabs, but is not to mice. Does not induce haemolysis in human erythrocytes.
Tissue specificity: Expressed by the venom gland.
PTM: Contains four disulfide bonds (By similarity) and C- terminal amidation."	"Gram-positive bacteria: Bacillus subtillis ICTA-07 (MIC=22 ?M), Microccocus luteus ATCC 4698 (MIC=43 ?M), Enterococcus faecalis WHO14 (MIC=34 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=77 ?M), Yersinia enterocolitica ATCC 9610 (MIC=49 ?M), Acinetobacter calcoaceticus ATCC 2305-5 (MIC=43 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19540868##22355312	Toxicon. 2009 Nov;54(6):802-817.##PLoS One. 2012;7(2):e30478.	"D¨ªaz P, D'Suze G, Salazar V, Sevcik C, Shannon JD, Sherman NE, Fox JW.##Guerrero-Vargas JA, Mour?o CB, Quintero-Hern¨¢ndez V, Possani LD, Schwartz EF."	Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes.##Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins.
DRAMP03694	KDGYLVGNDGCKYSCFTRPGTYCANECSRVKGKDGYCYAWMACYCYSMPNWVKTWNRATNRCGR	64	"Bactridin-2 (Bact2, Bactridine 2; P-Mice-Antm-beta* NaTx14.8; Arthropods, animals)"	P0CF37	Belongs to the long (4 C-C) scorpion toxin superfamily Sodiu	Not found	Tityus discrepans (Venezuelan scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against both Gram-positive bacteria (B.subtilis, M.luteus, E.faecalis) and Gram-negative bacteria (P.aeruginosa, Y.enterocolitica, A.calcoaceticus). Modifies membrane sodium permeability on Y.enterocolitica. Is toxic to mice, but is not to crabs. Induces concentration dependent haemolysis in human erythrocytes.
Tissue specificity: Expressed by the venom gland.
PTM: Contains four disulfide bonds (By similarity) and C-terminal amidation."	"Gram-positive bacteria: Bacillus subtillis ICTA-07 (MIC=30 ?M), Microccocus luteus ATCC 4698 (MIC=27 ?M), Enterococcus faecalis WHO14 (MIC=65 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=54 ?M), Yersinia enterocolitica ATCC 9610 (MIC=46 ?M), Acinetobacter calcoaceticus ATCC 2305-5 (MIC=27 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19540868##22355312	Toxicon. 2009 Nov;54(6):802-817.##PLoS One. 2012;7(2):e30478.	"D¨ªaz P, D'Suze G, Salazar V, Sevcik C, Shannon JD, Sherman NE, Fox JW.##Guerrero-Vargas JA, Mour?o CB, Quintero-Hern¨¢ndez V, Possani LD, Schwartz EF."	Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes.##Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins.
DRAMP03702	LFGLIPSLIGGLVSAFK	17	"Mucroporin (Antimicrobial peptide 36.21; Arthropods, animals)"	B9UIY3	Belongs to the short cationic antimicrobial peptide family	Not found	Lychas mucronatus (Chinese swimming scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Function: Cationic host defense peptide that have antibacterial activity by breaking membranes. Is more effective on Gram-positive than on Gram-negative bacteria. Its synthetic analog mucroporin-M1 is more effective.
Tissue specificity: Expressed by the venom gland. 
Miscellaneous: Minimum inhibitory concentrations (MIC) for Mucroporin-1 analog are the following: MIC=12.5 ?g/ml against E.coli AB94012, MIC=100 ?g/ml against P.aeruginosa AB93066, MIC=25 ?g/ml against B.thuringiensis AB92037, MIC=25 ?g/ml against B.subtilis AB91021, MIC=5 ?g/ml against S.aureus AB94004, and MIC=5 ?g/ml against the methicillin-resistant coagulase-negative Staphylococcus. Furthermore, this analog is as effective against antibiotic-resistant pathogens as it is against antibiotic-sensitive pathogens."	"Gram-negative bacteria: Escherichia coli AB94012 (MIC>100 ?g/ml), Pseudomonas aeruginosa AB93066 (MIC>100 ?g/ml);##Gram-positive bacteria: Bacillus thuringiensis AB92037 (MIC=25 ?g/ml), Bacillus subtilis AB91021 (MIC=50 ?g/ml), Staphylococcus aureus AB94004 (MIC=25 ?g/ml), Methicillin-resistant coagulase-negative S. aureus (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	20663230##18779362	BMC Genomics. 2010 Jul 28;11:452.##Antimicrob Agents Chemother. 2008 Nov;52(11):3967-3972.	"Ruiming Z, Yibao M, Yawen H, Zhiyong D, Yingliang W, Zhijian C, Wenxin L.##Dai C, Ma Y, Zhao Z, Zhao R, Wang Q, Wu Y, Cao Z, Li W."	"Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components.##Mucroporin, the first cationic host defense peptide from the venom of Lychas mucronatus."
DRAMP03706	FLFSLIPHAIGGLISAFK	18	"Antimicrobial peptide 1 (AamAP1; Arthropods, animals)"	G8YYA5	Not found	ap1	Androctonus amoreuxi (African fattail scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antibacterial and antifungal activity. Causes hemolysis on horse erythrocytes.
Tissue specificity: Expressed by the venom gland.
PTM: C-termianal amidation."	Gram-positive bacterium: Staphylococcus aureus (MIC=20 ?M);##Gram-negative bacterium: Escherichia coli (MIC=150 ?M).##Yeast: Candida albicans (MIC=64 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	22484288	Peptides. 2012 Jun;35(2):291-299.	"Almaaytah A, Zhou M, Wang L, Chen T, Walker B, Shaw C."	"Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog."
DRAMP03707	FPFSLIPHAIGGLISAIK	18	"Antimicrobial peptide 2 (AamAP2; Arthropods, animals)"	G8YYA6	Not found	ap2	Androctonus amoreuxi (African fattail scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antibacterial and antifungal activity. Causes hemolysis on horse erythrocytes.
Tissue specificity: Expressed by the venom gland.
PTM: C-termianal amidation."	Gram-positive bacterium: Staphylococcus aureus (MIC=48 ?M);##Gram-negative bacterium: Escherichia coli (MIC=120 ?M).##Yeast: Candida albicans (MIC=64 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	22484288	Peptides. 2012 Jun;35(2):291-299.	"Almaaytah A, Zhou M, Wang L, Chen T, Walker B, Shaw C."	"Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog."
DRAMP01392	GLLSGTSVRGSI	12	"Odorranain-V1 (OdV1; Frogs, amphibians, animals)"	A6MBS7	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	Function: Odorranain-V1 exhibites moderate antimicrobial activities against all of the tested microbes. Also has hemolytic activity against rabbit red cells	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=36.00 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=18.00 ¦Ìg/ml), Bacillus subtilis (MIC=18.00 ¦Ìg/ml).##Yeast: Candida albicans (MIC=9.00 ¦Ìg/ml)."	"[Ref.17272268] RCH=23.9 ¡À 4.7% against rabbit red blood cells. RCH, red cell hemolysis."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP01393	GLFGKSSVWGRKYYVDLAGCAKA	23	"Odorranain-W1 (OdW1; Frogs, amphibians, animals)"	A6MBS8	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	Function: Odorranain-W1 has hemolytic activity against rabbit red cell.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=12.60 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.30 ¦Ìg/ml), Bacillus subtilis (MIC=6.30 ¦Ìg/ml).##Yeast: Candida albicans (MIC=3.15 ¦Ìg/ml)."	"[Ref.17272268] RCH=17.6 ¡À 2.2% against rabbit red blood cells. RCH, red cell hemolysis."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP03715	FLSTLWNAAKSIF	13	"Amphiphatic peptide CT2 (VmCT2; Non-disulfide-bridged peptide 5.14, NDBP-5.14; Arthropods, animal"	I0DEB4	Belongs to the scorpion NDBP 5 family	Not found	Vaejovis mexicanus smithi (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Amphipatic peptide that shows antibacterial activities against both Gram-positive and Gram-negative bacteria. Has hemolytic at its MIC range, but shows a strong cytotoxic activity at higher concentrations, reaching 84% lysis at 50 ?M.
Tissue specificity: Expressed by the venom gland."	"[Ref.22342498]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10 uM), Bacillus subtilis ATCC 6633 (MIC=20 ?M), Streptococcus agalactiae (clinical isolate) (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?M), Salmonella typhi ATCC 6399 (MIC=10 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=10 ?M)."	"[Ref.22342498]25% hemolytic activity at 25 ¦ÌM, 84% hemolytic activity at 50 ¦ÌM against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	22342498	Peptides. 2012 Apr;34(2):290-295.	"Ram??rez-Carreto S, Quintero-Hern??ndez V, Jim??nez-Vargas JM, Corzo G, Possani LD, Becerril B, Ortiz E."	Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae.
DRAMP01730	FLPLIGRVLSGIL	13	"Temporin-A (Frogs, amphibians, animals)"	P56917 	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix	Not found	2MAA resolved by NMR.	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has hemolytic activity.
PTM: Leucine amide at position 13.
Tissue specificity: Expressed by the skin glands."	"[Ref.9022710] Gram-positive bacteria: Bacillus megaterium BM11 (LC=1.2 ?M), Staphylococcus aureus Cowan 1 (LC=2.3 ?M), Streptococcus pyogenes betahemolytic group A (LC=2.0 ?M);##Gram-negative bacteria: Escherichia coli D21 (LC=11.9 ?M), Escherichia coli D21e7 (LC=1.4 ?M), Escherichia coli D21f1 (LC=0.9 ?M), Escherichia coli D21f2 (LC=4.8 ?M), Escherichia coli D22 (LC=3.4 ?M), Yersinia pseudotuberculosis (LC=2.0 ?M), Pseudomonas aeruginosa ATCC 15692 (LC>360 ?M);##Yeast: Candida albicans ATCC 10261 (LC=3.4 ?M).(LC: Lethal concentration)"	[Ref.9022710] LC>120 ?M against Human red blood cells. (LC: Lethal concentration)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9022710	Eur J Biochem. 1996 Dec 15;242(3):788-792.	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D."	"Temporins, antimicrobial peptides from the European red frog Rana temporaria."
DRAMP03723	GKVWDWIKSAAKKIWSSEPVSQLKGQVLNAAKNYVAEKIGATPT	44	"Pandinin-1 (Pin1; Arthropods, animals)"	P83239	Belongs to the Scorpion family	Not found	Pandinus imperator (Emperor scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	MOA: Disrupts cell membranes through formation of pores.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC>20.8 ?M), Escherichia coli (MIC=20.8 ?M);##Gram-positive bacteria: Enterococcus faecalis (MIC=1.3 ?M), Bacillus subtilis (MIC=5.2 ?M), Staphylococcus epidermidis (MIC=5.2 ?M), Staphylococcus aureus (MIC=2.6 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11563967##16199510	Biochem J. 2001 Oct 1;359(Pt 1):35-45.##Biophys J. 2005 Dec;89(6):4067-4080. 	"Corzo G, Escoubas P, Villegas E, Barnham KJ, He W, Norton RS, Nakajima T.##Nomura K, Ferrat G, Nakajima T, Darbon H, Iwashita T, Corzo G."	Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.##Induction of morphological changes in model lipid membranes and the mechanism of membrane disruption by a large scorpion-derived pore-forming peptide.
DRAMP03724	FWGALAKGALKLIPSLFSSFSKKD	24	"Pandinin-2 (Pin2; Arthropods, animals)"	P83240	Belongs to the scorpion NDBP 4 family	Not found	Pandinus imperator (Emperor scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Hemolytic"	Protein level	Alpha helix 	Not found	None	"Function: Disrupts cell membranes through formation of pores. Has strong antimicrobial activity against Gram-positive bacteria and less active against Gram-negative bacteria. Possesses antifungal activity against C. albicans and hemolytic activity against sheep and pig erythrocytes.
Tissue specificity: Expressed by the venom gland."	"[Ref.11563967]Gram-negative bacteria: Pseudomonas aeruginosa (MIC=38.2 ?M), Escherichia coli (MIC=19.1 ?M);#Gram-positive bacteria: Enterococcus faecalis (MIC=2.4 ?M), Bacillus subtilis (MIC=4.8 ?M), Staphylococcus epidermidis (MIC=4.8 ?M), Staphylococcus aureus (MIC=2.4 ?M);##Yeast: Candida albicans (MIC=19.1 ?M)."	[Ref.11563967]Strong hemolytic activity (11.1-44.5 microM) against sheep erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11563967##15328050##15298871	Biochem J. 2001 Oct 1;359(Pt 1):35-45.##Biochim Biophys Acta. 2004 Aug 30;1664(2):182-188.##Biophys J. 2004 Oct;87(4):2497-507. 	"Corzo G, Escoubas P, Villegas E, Barnham KJ, He W, Norton RS, Nakajima T.##Belokoneva OS, Satake H, Mal'tseva EL, Pal'mina NP, Villegas E, Nakajima T, Corzo G.##Nomura K, Corzo G, Nakajima T, Iwashita T."	Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.##Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size.##Orientation and pore-forming mechanism of a scorpion pore-forming peptide bound to magnetically oriented lipid bilayers.
DRAMP03729	KWFNEKSIQNKIDEKIGKNFLGGMAKAVVHKLAKNEFMCVANVDMTKSCDTHCQKASGEKGYCHGTKCKCGVPLSY	76	"Opiscorpine-1 (Arthropods, animals)"	"Q5WR03, Q5WQZ8"	Belongs to the long chain scorpion toxin family (Class 3 subfamily)	Not found	Opistophthalmus carinatus (African yellow leg scorpion)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: The short amino-terminal segment of opiscorpine 1 (residues 1¨C35), named Jan-f3, has antimicrobial activity against fungi and the Gram-negative bacteria.
Tissue specificity: Expressed by the venom gland.
PTM: Contains three disulfide bonds (By similarity)."	"Fungi: Fusarium culmorum IMI180420 (IC50=8.8 ?M), Fusarium oxysporum MUCL39789 (IC50=10.04 ?M).##Gram-negative bacterium: Escherichia coli JM109 (MIC=12 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15241551	Cell Mol Life Sci. 2004 Jul;61(14):1751-1763.	"Zhu S, Tytgat J."	"The scorpine family of defensins: gene structure, alternative polyadenylation and fold recognition."
DRAMP03734	FKLGSFLKKAWKSKLAKKLRAKGKEMLKDYAKGLLEGGSEEVPGQ	45	"Parabutoporin (PP; Non-disulfide-bridged peptide 3.2, NDBP-3.2; Arthropods, animals)"	P83312	Belongs to the scorpion BPP family	Not found	Parabuthus schlechteri (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity. Induces reversible G-protein dependent Ca2+ release from intracellular stores and increase Ca2+ influx in HL-60 cells. Induces the activation of the Rac pathway in granulocytes. Synergistically enhances the excitatory effects of short and long chain ion-channel-specific neurotoxins by interaction with the neuronal membranes.
Tissue specificity: Expressed by the venom gland.
NOTE: residue 11, 44, 55 are uncertainty."	"[Ref.12354111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.1 ?M), Escherichia coli DH5a (MIC=3.1 ?M), Pseudomonas aeruginosa ATCC 257853 (MIC=6.3 ?M), Klebsiella pneumoniae ATCC 13833 (MIC=1.6 ?M), Salmonella choleraesuis ATCC 13311 (MIC=3.1 ?M), Haemophilus influenzae ATCC 19418 (MIC=3.1 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=6.3 ?M), Listeria monocytogenes NCTC 11994 (MIC=6.3 ?M), Micrococcus luteus ATCC 9341 (MIC=25 ?M);##Fungi: Neurospora crassa (MIC=2.5 ?M), Botrytis cinerea (MIC=3.5 ?M), Fusarium culmorum (MIC=0.3 ?M), Saccharomyces cerevisiae (MIC=2 ?M)."	[Ref.12354111]50% hemolysis is induced by about 38 ?M against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	12354111##12457879##14575699##15245865	Eur J Biochem. 2002 Oct;269(19):4799-4810.##Toxicon. 2002 Dec;40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7;311(1):90-97.##Peptides. 2004 Jul;25(7):1079-1084.	"Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, Thevissen K, Tytgat J, Van Eldere J, Van Der Walt J, Verdonck F.Willems J, Noppe W, Moerman L, van der Walt J, Verdonck F.##Moerman L, Verdonck F, Willems J, Tytgat J, Bosteels S.##Willems J, Moerman L, Bosteels S, Bruyneel E, Ryniers F, Verdonck F."	"Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.##Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes.##Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells.##Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions."
DRAMP03735	GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS	44	"Opistoporin-1 (OP1; Non-disulfide-bridged peptide 3.5; Opistoporin-3, OP3; Arthropods, animals)"	"P83313, Q5VJS8, Q5VJT0"	Belongs to the antimicrobial peptide scorpion family	Not found	Opistophthalmus carinatus (African yellow leg scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity.
Tissue specificity: Expressed by the venom gland."	"[Ref.12354111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 ?M), Escherichia coli DH5a (MIC=6.3 ?M), Serratia marcescens ATCC 133880 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 257853 (MIC=12.5 ?M), Klebsiella pneumoniae ATCC 13833 (MIC=6.3 ?M), Salmonella choleraesuis ATCC 13311 (MIC=25 ?M), Haemophilus influenzae ATCC 19418 (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=12.5 ?M), Bacillus subtilis IP 5832 (MIC=12.5 ?M), Listeria monocytogenes NCTC 11994 (MIC=12.5 ?M), Micrococcus luteus ATCC 9341 (MIC>50 ?M), Enterococcus faecalis ATCC 19433 (MIC=12.5 ?M), Staphylococcus aureus ATCC 292136.3 (MIC>50 ?M), Streptococcus pneumoniae ATCC 33400 (MIC=12.5 ?M), Nocardia asteroides ATCC 3308 (MIC>50 ?M);##Fungi: Neurospora crassa (IC50=0.8 ?M), Botrytis cinerea (IC50=3.1 ?M), Fusarium culmorum (IC50=0.8 ?M), Saccharomyces cerevisiae (IC50=2 ?M)."	"[Ref.12354111]10% hemolytic activity at 10 ?M, 30% hemolytic activity at 100 ?M against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	12354111##12457879##14575699	Eur J Biochem. 2002 Oct;269(19):4799-4810.##Toxicon. 2002 Dec;40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7;311(1):90-97.	"Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, Thevissen K, Tytgat J, Van Eldere J, Van Der Walt J, Verdonck F.Willems J, Noppe W, Moerman L, van der Walt J, Verdonck F.##Moerman L, Verdonck F, Willems J, Tytgat J, Bosteels S."	"Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.##Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes.##Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells."
DRAMP03738	GWINEEKIQKKIDERMGNTVLGGMAKAIVHKMAKNEFQCMANMDMLGNCEKHCQTSGEKGYCHGTKCKCGTPLSY	75	"Scorpine (defensins; Arthropods, animals)"	P56972	Belongs to the long chain scorpion toxin family (Class 3 subfamily)	Not found	Pandinus imperator (Emperor scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has antibacterial activity and a potent inhibitory effect on the ookinete (ED(50) 0.7 uM) and gamete (ED(50) 10 uM) stages of Plasmodium berghei development.	Gram-positive bacterium: Bacillus subtilis (MIC=1.0 ?M);##Gram-negative bacterium: Klebsiella pneumoniae (MIC=10 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10767415	FEBS Lett. 2000 Apr 14;471(2-3):165-168.	"Conde R, Zamudio FZ, Rodr??guez MH, Possani LD."	"Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom."
DRAMP02828	GLFRRLRDSIRRGQQKILEKARRIGERIKDIFRG	34	"BMAP-34 (BMAP 34, bovine cathelicidin, cattle, ruminant, mammals, animals)"	P56425	Belongs to the cathelicidin family.	CATHL7	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. 
Tissue specificity: Expressed in bone marrow myeloid cells, spleen and testis."	"[Ref.9795251] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3 ¦ÌM), Staphylococcus aureus Cowan 1 (MIC=3 ¦ÌM), Staphylococcus aureus (MRSA, clinical isolate) (MIC=6 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=1.5 ¦ÌM), Bacillus megaterium Bm 11 (MIC=3 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1.5 ¦ÌM), Escherichia coli ML-35 (MIC=1.5 ¦ÌM), Escherichia coli D21 (MIC=1.5 ¦ÌM), Escherichia coli D22 (MIC=1.5 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC=3 ¦ÌM), Salmonella enteritidis (clinical isolate) (MIC=3 ¦ÌM), Serratia marcescens ATCC 8100 (MIC=1.5 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC¡Ý48 ¦ÌM);##Fungus: Candida albicans (clinical isolate) (MIC>96 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9409740##9795251	FEBS Lett. 1997 Nov 17;417(3):311-5.##Biochim Biophys Acta. 1998 Oct 23;1425(2):361-368.	"Scocchi M, Wang S, Zanetti M.##Gennaro R, Scocchi M, Merluzzi L, Zanetti M."	Structural organization of the bovine cathelicidin gene family and identification of a novel member.##Biological characterization of a novel mammalian antimicrobial peptide.
DRAMP02926	KWCFRVCYRGICYRRCR	17	"Tachyplesin I (Tac; TP1; Horseshoe Crab, arachnids, Chelicerata, arthropods, invertebrates, animals)"	P14213	Belongs to the tachyplesin/polyphemusin family.	Not found	Tachypleus tridentatus (Japanese horseshoe crab)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Anti-HIV, Anti-cancer"	Protein level	Beta strand	This stability is due to the rigid structure imposed by the two disulfide linkages. Its amphipathic nature is closely associated with biological activity. A 	"1MA2, 1MA5, 6PIN, 1WO0, 1WO1, 2MDB, 2RTV resolved by NMR."	"Function:  Significantly inhibits the growth of Gram-negative and Gram-positive bacteria, also anti-HIV activity may be due to the inhibition of virual adsorption to cells.
PTM: Contains two disulfide bonds 3-16; 7-12 and Arginine amide at R17."	No MICs found in DRAMP database	[Ref.29870123] 9.6% hemolytic activity at 8 ¦Ìg/mL and 72.8% hemolytic activity at 512 ¦Ìg/mL against human red blood cells.	Cyclic	Free	Amidation (Arg17)	"Disulfide bond between Cys3 and Cys16,Cys7 and Cys12."	L	"[Ref.28429216]It possessed a cytotoxic effect on HL-60 cells (acutehuman promyelocytic leukemia cells) , K562 cells(myelogenous leukemia cells) , TSU cells (prostatecancer cells) ."	Cell membrane	12369825##2229025	Biochemistry 2002; 41: 12359.##J Biochem. 1990 Aug;108(2):261-266.	"Laederach A, Andreotti AH, Fulton, DB.##Muta T, Fujimoto T, Nakajima H, Iwanaga S."	"Solution and Micelle-Bound Structures of Tachyplesin I and its Active Aromatic Linear Derivatives.##Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor."
DRAMP03746	FIGAIARLLSKIF	13	"Peptide BmKn2 (Biologically active peptide 4; NDBP-5.1; Arthropods, animals)"	Q6JQN2	Not found	Kn2	Mesobuthus martensii (Buthus martensii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation."	"Gram-positive bacteria: Staphylococcus aureus (MIC=0.6 ?g/ml), Micrococcus luteus(MIC=8 ?g/ml), Bacillus subtilis (MIC=5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=1.5 ?g/ml), Pseudomonas aeruginosa (MIC=21.3 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15062994	Peptides. 2004 Feb;25(2):143-150.	"Zeng XC, Wang SX, Zhu Y, Zhu SY, Li WX."	Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch.
DRAMP03748	FRFGSFLKKVWKSKLAKKLRSKGKQLLKDYANKVLNGPEEEAAAPAE	47	"Bradykinin-potentiating peptide BmK3 (Bpp BmK3; NDBP-3.3; Arthropods, animals)"	Q9Y0X4	Belongs to the scorpion BPP family	Not found	Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Alpha helix (predict)	"The secondary structure prediction for BmKbpp reveals that BmKbpp is composed of an ¦Á-helical structure from amino residues 3-35, followed by a coil-coiled region of three residues (NGP), and ended with an ¦Á-helical region of 9 residues (ref.2)."	None	"Function: Amphipathic peptide that shows bradykinin potentiating activity and antimicrobial activities against bacteria and fungi. Has higher antibacterial activities against Gram-negative than against Gram-positive bacteria. Also inhibits NADPH oxidase-dependent superoxide production (IC50 is 0.4 ?M on granulocytes stimulated with PMA, IC50 is 0.51 ?M on HL-60 cells undifferentiated and IC50 is 0.53 ?M on HL-60 cells treated with DMSO). The C-terminal peptide shows a higher bradykinin potentiating activity than the complete peptide.
Tissue specificity: Expressed by the venom gland.
Miscellaneous: Shows hemolytic activity. Shows a alpha-helical structure. The genomic DNA coding for this protein is not a continuous sequence in the genome. The transcript of this protein may be generated by trans-splicing, by which exons from two independently transcribed pre-mRNAs are joined to form a single mature transcript."	"[Ref.22115565]Gram-negative bacteria: Escherichia coli DH 5-¦Á (MIC=2.3 ?M), Haemophilus in?uenzae ATCC 31517 (MIC=3.2 ?M), Klebsiella pneumoniae ATCC 13882 (MIC=2.8 ?M), Salmonella enterica ATCC 8090 (MIC=2.3 ?M), Pseudomonas aeruginosa ATCC 9229 (MIC=4.7 ?M), Serratia marcescens ATCC 13880 (MIC=68.2 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=24.4 ?M), Listeria monocytogenes ATCC 35152 (MIC=5.7 ?M), Micrococcus luteus ATCC 9341 (MIC=20.3 ?M), Enterococcus faecalis ATCC 14508 (MIC=57.1 ?M), Nocardia asteroides ATCC 3308 (MIC>70 ?M), Staphylococcus aureus ATCC 14458 (MIC>70 ?M);##Fungi: Neurospora crassa FGSC 2489 (IC50=2 ?M), Botrytis cinerea ATCC 28387 (IC50=3.1 ?M), Fusarium culmorum ATCC 32973 (IC50=0.2 ?M)."	"[Ref.22115565]3.5% hemolytic activity at 6 ¦ÌM, 11.2% hemolytic activity at 10 ¦ÌM, 22.5% hemolytic activity at 30 ¦ÌM, 33.9% hemolytic activity at 50 ¦ÌM against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10868911##22115565	IUBMB Life. 2000 Mar;49(3):207-210.##Peptides. 2012 Jan;33(1):44-51.	"Zeng XC, Li WX, Peng F, Zhu ZH.##Zeng XC, Wang S, Nie Y, Zhang L, Luo X."	"Cloning and characterization of a novel cDNA sequence encoding the precursor of a novel venom peptide (BmKbpp) related to a bradykinin-potentiating peptide from Chinese scorpion Buthus martensii Karsch.##Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides."
DRAMP03750	IFGAIAGLLKNIF	13	"Venom antimicrobial peptide-6 (Meucin-13; NDBP-5; Arthropods, animals)"	"E4VP07, E4VP35"	Belongs to the scorpion NDBP 5 family	Not found	Mesobuthus eupeus (Lesser Asian scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: Amphipathic peptide that exhibits extensive cytolytic activities against both prokaryotic and eukaryotic cells. Is more potent against Gram-positive bacteria (lethal concentration (LC=0.25-2.9 ?M) than against Gram-negative bacteria (LC=6.2->50 ?M), and fungi (LC=14.1->50 ?M). Shows hemolytic activity against rabbit erythrocytes and cytolysis against rat dorsal root ganglions. In vivo, intravenous injection into mice tail provokes uncomfortable symptoms with a death rate of 12.5%.
Tissue specificity: Expressed by the venom gland."	"[Ref.19088182]Gram-positive bacteria: Bacillus sp. DM-1 (MIC=2 ?M), Micrococcus luteus (MIC=2.9 ?M), Bacillus megaterium (MIC=0.25 ?M);##Gram-negative bacteria: Agrobacterium tumefaciens (MIC=11.8 ?M), Escherichia coli (MIC=7.90 ?M), Shewanella oneidensis (MIC=6.20 ?M), Stenotrophomonus sp. YC-1 (MIC=6.20 ?M);##Fungi: Beauveria spp. (MIC=14.1 ?M), Neurospora crassa (MIC=18.3 ?M), Candida albicans (MIC=42.8 ?M), Saccharomyces cerevisiae (MIC=18.3 ?M)."	"[Ref.19088182]37.7% hemolytic activity at 6.25 M, 59.2% hemolytic activity at 12.5 M against rabbit red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	19088182	FASEB J. 2009 Apr;23(4):1230-1245.	"Gao B, Sherman P, Luo L, Bowie J, Zhu S."	Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides.
DRAMP03751	FFGHLFKLATKIIPSLFQ	18	"Venom antimicrobial peptide-9 (Meucin-18; NDBP-5; Arthropods, animals)"	E4VP50	Belongs to the ponericin-W family	Not found	Mesobuthus eupeus (Lesser Asian scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: Amphipathic peptide that exhibits extensive cytolytic activities against both prokaryotic and eukaryotic cells. Is more potent against Gram-positive bacteria (lethal concentration (LC=1.5-10.9 ?M) than against Gram-negative bacteria (LC=6.2-50 ?M), and fungi (LC=25.1-8.3 ?M). Is lethal to the fungus Beauveria sp (LC=1.9 ?M), a highly lethal pathogenic fungus to insects and resistant to many AMPs. Shows hemolytic activity against rabbit erythrocytes and cytolysis against rat dorsal root ganglions. In vivo, intravenous injection into mice tail provokes uncomfortable symptoms with a death rate of 12.5%.
Tissue specificity: Expressed by the venom gland."	"[Ref.19088182]Gram-positive bacteria: Bacillus sp. DM-1 (MIC=0.60 ?M), Micrococcus luteus (MIC=0.60 ?M), Bacillus megaterium (MIC=0.25 ?M);##Gram-negative bacteria: Agrobacterium tumefaciens (MIC=6.00 ?M), Escherichia coli (MIC=2.40 ?M), Shewanella oneidensis (MIC=1.50 ?M), Stenotrophomonus sp. YC-1(MIC=2.60 ?M), Salmonella typhimurium (MIC=10.9 ?M);##Fungi: Beauveria spp.(MIC=1.9 ?M), Neurospora crassa (MIC=5.2 ?M), Candida albicans (MIC=25.1 ?M), Saccharomyces cerevisiae (MIC=25.1 ?M), Aspergillus fumigatus (MIC=8.3 ?M), Geotrichum candidum (MIC=3.5 ?M)."	"[Ref.19088182]74% hemolytic activity at 6.25 M, 100% hemolytic activity at 12.5 M against rabbit red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	19088182	FASEB J. 2009 Apr;23(4):1230-1245.	"Gao B, Sherman P, Luo L, Bowie J, Zhu S."	Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides.
DRAMP03752	FLFSLIPSAISGLISAFK	18	"Peptide BmKb1 (Non-disulfide-bridged peptide 4.2, NDBP-4.2; Arthropods, animals)"	"Q718F4, Q2M5D6 Q95P85"	Not found	Kb1	Mesobuthus martensii (Manchurian scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation."	"Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Micrococcus luteus(MIC=81.5 ?g/ml), Bacillus subtilis (MIC=48.8 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=18.1 ?g/ml), Pseudomonas aeruginosa (MIC=90.8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (Forms a helical membrane channel in the prey)	15062994##16040157	Peptides. 2004 Feb;25(2):143-150.##Peptides. 2005 Dec;26(12):2427-2433.	"Zeng XC, Wang SX, Zhu Y, Zhu SY, Li WX.##Luo F, Zeng XC, Hahin R, Cao ZJ, Liu H, Li WX."	Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch.##Genomic organization of four novel nondisulfide-bridged peptides from scorpion Mesobuthus martensii Karsch: gaining insight into evolutionary mechanism.
DRAMP03753	GFWGSLWEGVKSVV	14	"Amphipathic peptide CT1 (StCT1; Non-disulfide-bridged peptide 5, NDBP-5; Arthropods, animals)"	P0DJO3	Not found	Not found	Scorpiops tibetanus (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide that is rapidly bactericidal against Gram-positive bacteria (MIC=12.5 ?g/ml against S.aureus, and MIC=100 ?g/ml against M. luteus). Is also active against clinical antibiotics-resistant bacterial strains.
PTM: C-terminal amidation and Cleavage on pair of basic residues.
Miscellaneous: Is highly capable of inhibiting antibiotic-resistant pathogen growth, including methicillin-resistant S.aureus. In vivo, shows high antimicrobial activity on a S.aureus-infected mouse model."	"Gram-positive bacteria: Staphylococcus aureus AB94004 (MIC=12.5 ?g/ml), Bacillus thuringensis AB92037 (MIC>100 ?g/ml), Bacillus subtilis AB91021 (MIC>100 ?g/ml), Micrococcus luteus AB93113 (MIC=100 ?g/ml), MRSA P1374 (MIC=200 ?g/ml), MRSA P1386 (MIC=250 ?g/ml);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=100 ?g/ml), Pseudomonas aeruginosa AB93066 (MIC=100 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	19854232	Peptides. 2010 Jan;31(1):22-26.	"Yuan W, Cao L, Ma Y, Mao P, Wang W, Zhao R, Wu Y, Cao Z, Li W."	Cloning and functional characterization of a new antimicrobial peptide gene StCT1 from the venom of the scorpion Scorpiops tibetanus.
DRAMP03754	GFWGKLWEGVKSAI	14	"Amphipathic peptide CT2 (StCT2; Non-disulfide-bridged peptide 5, NDBP-5; Arthropods, animals)"	P0DJO4	Not found	Not found	Scorpiops tibetanus (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"PTM: C-terminal amidation and Cleavage on pair of basic residues.
Miscellaneous: Is highly capable of inhibiting antibiotic-resistant pathogen growth, including methicillin-resistant S.aureus. In vivo, shows high antimicrobial activity on a S.aureus-infected mouse model."	"Gram-positive bacteria: Staphylococcus aureus AB94004 (MIC=6.25 ?g/ml), Bacillus thuringensis AB92037 (MIC=50 ?g/ml), Bacillus subtilis AB91021 (MIC=25 ?g/ml), Micrococcus luteus AB93113 (MIC=25 ?g/ml), PRSA P1383 (MIC=12.5 ?g/ml), PRSE P1389 (MIC=12.5 ?g/ml), MRCNS P1369 (MIC=6.25 ?g/ml), MRSA P1374 (MIC=6.25 ?g/ml), MRSA P1386 (MIC=12.5 ?g/ml), MRSA P1381 (MIC=25 ?g/ml), MSSE P1111 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=50 ?g/ml), Pseudomonas aeruginosa AB93066 (MIC>100 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	22542475	Peptides. 2012 Aug;36(2):213-220.	"Cao L, Li Z, Zhang R, Wu Y, Li W, Cao Z."	"StCT2, a new antibacterial peptide characterized from the venom of the scorpion Scorpiops tibetanus."
DRAMP03774	GFWGKLWEGVKNAI	14	"UyCT1 (Arthropods, animals)"	No entry found	Not found	Not found	Urodacus yaschenkoi (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.23182832]Gram-positive bacterium: Staphylococcus aureus ATCC 25953 (MIC=15 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=10 ?M)."	"[Ref.23182832]20% hemolytic activity at 12.5 ¦ÌM, 45% hemolytic activity at 25 ¦ÌM, 80% hemolytic activity at 50 ¦ÌM, 90% hemolytic activity at 100 ¦ÌM against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23182832	Toxicon. 2013 Mar 1;63:44-54.	"Luna-Ram¨ªrez K, Quintero-Hern¨¢ndez V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD."	"Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity."
DRAMP03775	FWGKLWEGVKNAI	13	"UyCT2 (Arthropods, animals)"	No entry found	Not found	Not found	Urodacus yaschenkoi (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.23182832]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=40 ?M)."	"[Ref.23182832]3% hemolytic activity at 12.5 ¦ÌM, 6% hemolytic activity at 25 ¦ÌM, 5% hemolytic activity at 50 ¦ÌM, 35% hemolytic activity at 100 ¦ÌM against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23182832	Toxicon. 2013 Mar 1;63:44-54.	"Luna-Ram¨ªrez K, Quintero-Hern¨¢ndez V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD."	"Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity."
DRAMP03776	ILSAIWSGIKSLF	13	"UyCT3 (Arthropods, animals)"	No entry found	Not found	Not found	Urodacus yaschenkoi (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.23182832]Gram-positive bacterium: Staphylococcus aureus ATCC 25953 (MIC=10 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=6 ?M)."	"[Ref.23182832]30% hemolytic activity at 12.5 ¦ÌM, 90% hemolytic activity at 25 ¦ÌM, 92% hemolytic activity at 50 ¦ÌM, 90% hemolytic activity at 100 ¦ÌM against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23182832	Toxicon. 2013 Mar 1;63:44-54.	"Luna-Ram¨ªrez K, Quintero-Hern¨¢ndez V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD."	"Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity."
DRAMP03777	IWSAIWSGIKGLL	13	"UyCT5 (Arthropods, animals)"	No entry found	Not found	Not found	Urodacus yaschenkoi (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.23182832]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=2 ?M).##Gram-positive bacterium: Staphylococcus aureus ATCC 25953 (MIC=1 ?M)."	"[Ref.23182832]27% hemolytic activity at 12.5 ¦ÌM, 65% hemolytic activity at 25 ¦ÌM, 95% hemolytic activity at 50 ¦ÌM, 90% hemolytic activity at 100 ¦ÌM against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23182832	Toxicon. 2013 Mar 1;63:44-54.	"Luna-Ram¨ªrez K, Quintero-Hern¨¢ndez V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD."	"Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity."
DRAMP03814	GILDTLKQFAKGVGKWLVKGAAQGVLSTVSCKLAKTC	37	D16W (GGN4 analogue peptide with single substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Single substitution of aspartic acid 16 by tryptophan (D16W) in the native GGN4. Has hemolytic activity as well as the antimicrobial activity.	"[Ref.12199716]Gram-positive bacteria: Micrococcus luteus (MIC=25 ?g/ml), Bacillus subtilis (MIC=2.5 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=10 ?g/ml), Shigella dysentariae (MIC=10 ?g/ml), Pseudomonas putida (MIC=100 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=10 ?g/ml), Salmonella typhimurium (MIC=50 ?g/ml)."	"[Ref.12199716] 1.97% hemolytic activity at 10 ?g/mL, 52.9% hemolytic activity at 100 ?g/mL against human red blood cells."	Cyclic	Free	Cyclization(Cys31 and Cys37).	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	12199716	Eur J Biochem. 2002 Sep;269(17):4367-4374.	"Won HS, Park SH, Kim HE, Hyun B, Kim M, Lee BJ, Lee BJ."	Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4.
DRAMP03815	GILDTLKQFAKGVGKWLVKGAAQ	23	D16W-N23 (single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Comment: Single substitution of aspartic acid 16 by tryptophan (D16W) in the Delta24-37 GGN4, which is a peptide analogue with 14 residues truncated from the C-terminus of GGN4."	"Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Bacillus subtilis (MIC=25 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=125 ?g/ml), Eshchericia coli (MIC=25 ?g/ml), Salmonella typhimurium (MIC=125 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12199716	Eur J Biochem. 2002 Sep;269(17):4367-4374.	"Won HS, Park SH, Kim HE, Hyun B, Kim M, Lee BJ, Lee BJ."	Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4.
DRAMP03816	GILDTLKQFAKGVGKFLVKGAAQ	23	D16F-N23 (single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Comment: Single substitution of aspartic acid 16 by phenylalanine (D16F) in the Delta24-37 GGN4, which is a peptide analogue with 14 residues truncated from the C-terminus of GGN4."	"Gram-positive bacterium: Bacillus subtilis (MIC=25 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=100 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=200 ?g/ml), Eshchericia coli (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12199716	Eur J Biochem. 2002 Sep;269(17):4367-4374.	"Won HS, Park SH, Kim HE, Hyun B, Kim M, Lee BJ, Lee BJ."	Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4.
DRAMP03823	ALWKTLLKKVLKA	13	Dermaseptin derivative K4-S4-(1-13)	P80280	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix (1 helices; 5 residues)	"The Ramachandran plot of P showes that residues 2 and 4-13 are all in ¦Á-helix regions of the plot; the residues in all of the structures are in the core ¦Á-helix region for residues 2, 3, and 6-11, and both residue 5 and 12 had over 60% in the core and the rest in allowed ¦Á-helix regions."	2DD6 resolved by NMR.	Function: Has antibacterial activity. Also has hemolytic activity against red blood cells (RBCs).	[Ref.15917541]Gram-negative bacterium: Escherichia coli U16318 (MIC=9-3 ?M);##Gram-positive bacterium: Staphylococcus aureus B38302 (MIC=4.5-1.5 ?M).	[Ref.15917541]LC50=50 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	16407175##15917541	J Biol Chem. 2006 Apr 7;281(14):9432-9438.##Antimicrob Agents Chemother. 2005 Jun;49(6):2412-2420.	"Shalev DE, Rotem S, Fish A, Mor A.##Radzishevsky IS, Rotem S, Zaknoon F, Gaidukov L, Dagan A, Mor A."	Consequences of N-acylation on structure and membrane binding properties of dermaseptin derivative K4-S4-(1-13).##Effects of acyl versus aminoacyl conjugation on the properties of antimicrobial peptides.
DRAMP03824	FKCRRWQWR	9	CNBr-cleaved lactoferricin Subfragment 1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: The antibacterial activity of this subfragment 1 is not as potent as that of intact lactoferricin, having an MIC of 10 to 50 ?M for most of the bacteria tested."	"Gram-negative bacteria: Escherichia coli L361 (MIC=10 ?M), Pseudomonas fluorescens (MIC=50 ?M), Salmonella Salford (MIC>50 ?M), Escherichia coli O:9 (MIC=15 ?M);##Gram-positive bacteria: Bacillus cereus (MIC=20 ?M), Listeria monocytogenes (MIC=10 ?M), Staphylococcus aureus (MIC>50 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8980754	Antimicrob Agents Chemother. 1997 Jan;41(1):54-59.	"Hoek KS, Milne JM, Grieve PA, Dionysius DA, Smith R."	Antibacterial activity in bovine lactoferrin-derived peptides.
DRAMP03825	KKLGAPSITCVRRAFA	16	CNBr-cleaved lactoferricin Subfragment 2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Subfragment 2 had weak antibacterial activity against L. monocytogenes and both E. coli isolates, being effective in the range of 40 to 60 ?M."	"Gram-negative bacteria: Escherichia coli L361 (MIC=50 ?M), Pseudomonas fluorescens (MIC>100 ?M), Salmonella Salford (MIC>100 ?M), Escherichia coli O:9 (MIC=60 ?M);##Gram-positive bacteria: Bacillus cereus (MIC>100 ?M), Listeria monocytogenes (MIC=40 ?M), Staphylococcus aureus (MIC>100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8980754	Antimicrob Agents Chemother. 1997 Jan;41(1):54-59.	"Hoek KS, Milne JM, Grieve PA, Dionysius DA, Smith R."	Antibacterial activity in bovine lactoferrin-derived peptides.
DRAMP03826	KNLRRIIRKIIHIIKKYG	18	Ovispirin-1 (OV-1; N-terminal 18 amino acids of SMAP-29)	No entry found	Not found	Not found	Synthetic construct	"Antibacterial, Cytotoxic, Anti-Gram+, Anti-Gram-, Antimicrobial"	Synthetic	Alpha helix (1 helices; 13 residues)	Ovispirin-1 is a uniform ¦Á-helix over residues 4-16. 	1HU5 resolved by NMR.	"Function: Possess potently antimicrobial activity. It is also highly cytotoxic to human epithelial cells (ME-180 cervical cells: 100% at 200 ?g/ml, 93.6% at 50 ?g/ml, 55.3% at 25 ?g/ml) and A-549 pulmonary cells: 99.7% at 200 ?g/ml, 99.4% at 50 ?g/ml, 90.9% at 25 ?g/ml) and hemolytic for human Human red blood cells."	"[Ref.11932493]Gram-negative bacteria: Pseudomonas aeruginosa 9 strains (MIC=0.7-5.6 ?g/ml), Stenotrophomonas maltophilia 5 strains (MIC=0.5-2.2 ?g/ml);##Gram-positive bacteria: Listeria monocytogenes EGD [n=3] (MIC=1.5¡À0.3 ?g/ml), Staphylococcus aureus 930918 [n=3] (MIC=1.0¡À0.13 ?g/ml)."	"[Ref.11932493]55% hemolytic at 40 ?g/mL, 70.2% hemolytic activity at 80 ?g/mL against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11932493	Protein Eng. 2002 Mar;15(3):225-232.	"Sawai MV, Waring AJ, Kearney WR, McCray PB Jr, Forsyth WR, Lehrer RI, Tack BF."	Impact of single-residue mutations on the structure and Function: of ovispirin/novispirin antimicrobial peptides.
DRAMP03827	KNLRRIIRKGIHIIKKYG	18	Novispirin G-10 (mutation of Ovispirin-1)	No entry found	Not found	Not found	Synthetic construct	"Antibacterial, Cytotoxic, Anti-Gram+, Anti-Gram-, Antimicrobial"	Synthetic	Alpha helix (2 helices; 11 residues)	"Novispirin G-10 shows an ¦Á-helix-hinge-310 helix structural motif with residues 4-11 forming the ¦Á-helix, residues 12 and 13 forming the hinge and residues 14-16 forming the 310 helix."	1HU6 resolved by NMR.	"Function: Possess potently antimicrobial activity. Also has hemolytic activity against Human red blood cells, and has cytotoxicity activity against ME-180 cervical cells (33.2% at 200 ?g/ml, 5.0% at 50 ?g/ml, 7.1% at 25 ?g/ml) and A-549 pulmonary cells (33.2% at 200 ?g/ml, 14.6% at 50 ?g/ml, 10.0% at 25 ?g/ml)."	"[Ref.11932493]Gram-negative bacteria: Pseudomonas aeruginosa 9 strains (MIC=0.11-12.7 ?g/ml), Stenotrophomonas maltophilia 5 strains (MIC=0.29-3.6 ?g/ml);##Gram-positive bacteria: Listeria monocytogenes EGD [n=3] (MIC=1.4¡À0.4 ?g/ml), Staphylococcus aureus 930918 [n=3] (MIC=4.6¡À1.7 ?g/ml)."	"[Ref.11932493]1.8% hemolytic at 40 ?g/mL, 2.5% hemolytic activity at 80 ?g/mL against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11932493	Protein Eng. 2002 Mar;15(3):225-232.	"Sawai MV, Waring AJ, Kearney WR, McCray PB Jr, Forsyth WR, Lehrer RI, Tack BF."	Impact of single-residue mutations on the structure and Function: of ovispirin/novispirin antimicrobial peptides.
DRAMP03828	KNLRRITRKIIHIIKKYG	18	Novispirin T-7 (mutation of Ovispirin-1)	No entry found	Not found	Not found	Synthetic construct	"Antibacterial, Cytotoxic, Anti-Gram+, Anti-Gram-, Antimicrobial"	Synthetic	Alpha helix (1 helices; 11 residues)	Novispirin T-7 is a well-defined ¦Á-helix over residues 7-17 with residues 3-6 forming a type IV turn.	1HU7 resolved by NMR.	"Function: Possess potently antimicrobial activity. Also has hemolytic activity against Human red blood cells, and has cytotoxicity activity against ME-180 cervical cells (81.5% at 200 ?g/ml, 28.4% at 50 ?g/ml, 15.6% at 25 ?g/ml) and A-549 pulmonary cells (81.5% at 200 ?g/ml, 22.9% at 50 ?g/ml, 15.4% at 25 ?g/ml)."	"[Ref.11932493]Gram-negative bacteria: Pseudomonas aeruginosa 9 strains (MIC=0.26-27.8 ?g/ml), Stenotrophomonas maltophilia 5 strains (MIC=0.32-1.75 ?g/ml);##Gram-positive bacteria: Listeria monocytogenes EGD (MIC=2.4¡À1.5 [n=3] ?g/ml), Staphylococcus aureus 930918 (MIC=3.3¡À1.5 [n=3] ?g/ml)."	"[Ref.11932493]3% hemolytic at 40 ?g/mL, 10% hemolytic activity at 80 ?g/mL against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11932493	Protein Eng. 2002 Mar;15(3):225-232.	"Sawai MV, Waring AJ, Kearney WR, McCray PB Jr, Forsyth WR, Lehrer RI, Tack BF."	Impact of single-residue mutations on the structure and Function: of ovispirin/novispirin antimicrobial peptides.
DRAMP03829	GLKKLLGKLLKKLGKLLLK	19	GLK-19	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anticancer"	Synthetic	Not found	Not found	None	Function: GLK-19 showed a higher activity against Escherichia coli than human LL-37.	Gram-negative bacterium: Escherichia coli K12 (MIC=10 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18957441	Nucleic Acids Res. 2009 Jan;37(Database issue):D933-937.	"Wang G, Li X, Wang Z."	APD2: the updated antimicrobial peptide database and its application in peptide design.
DRAMP03830	GLWNSIKIAGKKLFVNVLDKIRCKVAGGCKTSPDVEYHK	39	Palustrin-2ISb + 3aa	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), S. aureus (MRSA) (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21911019	Peptides. 2011 Oct;32(10):2052-2057.	"Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K."	Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-3 family isolated from the skin of the endangered frog Odorrana ishikawae.
DRAMP03831	GLWNSIKIAGKKLFVNVLDKIRCKVAGGC	29	Palustrin-2ISb-des-C7	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=1.6 ?M), S. aureus (MRSA) (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization(Cys23 and Cys29).	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	21911019	Peptides. 2011 Oct;32(10):2052-2057.	"Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K."	Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-4 family isolated from the skin of the endangered frog Odorrana ishikawae.
DRAMP03832	GLWDSIKIAGKKLFVNVLDKIRCKVAGGC	29	Palustrin-2ISb-des-C7-4D	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), S. aureus (MRSA) (MIC=12.5 ?M);##yeast Candida albicans (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization(Cys23 and Cys29).	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	21911019	Peptides. 2011 Oct;32(10):2052-2057.	"Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K."	Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-5 family isolated from the skin of the endangered frog Odorrana ishikawae.
DRAMP03833	GLWNSIKIAGKNLFVNVLDKIRCKVAGGC	29	Palustrin-2ISb-des-C7-12N	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), S. aureus (MRSA) (MIC=12.5 ?M);##yeast Candida albicans (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization(Cys23 and Cys29).	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	21911019	Peptides. 2011 Oct;32(10):2052-2057.	"Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K."	Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-6 family isolated from the skin of the endangered frog Odorrana ishikawae.
DRAMP03834	GLWNSIKIAGKKLFVNVLDKIRSKVAGGS	29	"Palustrin-2ISb-des-C7-23,29S"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=3.1 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), S. aureus (MRSA) (MIC=25 ?M);##yeast Candida albicans (MIC=100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21911019	Peptides. 2011 Oct;32(10):2052-2057.	"Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K."	Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-7 family isolated from the skin of the endangered frog Odorrana ishikawae.
DRAMP03852	GLARIVVIRVAR	12	G1 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=125 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=125 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03853	RGARIVVIRVAR	12	G2 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=31 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03854	RRARIVVIRVAR	12	R2 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=16 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03855	RLRRIVVIRVAR	12	R3 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03856	RLWRIVVIRVAR	12	W3 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.5 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03857	RLARRVVIRVAR	12	R5 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=63 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=125 ?g/ml).##Yeast: Candida albicans (MIC=125 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03858	RLARIVKIRVAR	12	K7 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=125 ?g/ml), Staphylococcus epidermidis (MIC=31 ?g/ml), Enterococcus faecalis (MIC=125 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03859	RLARIVVIRWAR	12	W10 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03860	RLARIVVIRVRR	12	R11 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03861	RLARIVVIRVAG	12	G12 (Bac2A variant through single amino acid substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=63 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=31 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=63 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03862	RLRRIVVIRVRR	12	Sub2 (Bac2A variant through two amino acids substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03863	RRWRIVVIRVRR	12	Sub3 (Bac2A variant through three amino acids substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2 ?g/ml), Escherichia coli (MIC=2.5 ?g/ml), Salmonella typhimurium (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03864	RRWKIVVIRWRR	12	Sub5 (Bac2A variant through five amino acids substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.5 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03865	RWWKIWVIRWWR	12	Sub6 (Bac2A variant through six amino acids substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=1 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml).."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03866	KIWVIRWR	8	Bac8a (Bac2A variant)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=16 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03867	RIWVIRWR	8	Bac8b (Bac2A variant)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03868	RIWVIWRR	8	Bac8c (Bac2A variant)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03869	RRWVIWRR	8	Bac8d (Bac2A variant)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=250 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=8 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml).##Yeast: Candida albicans (MIC=63 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366	Nat Biotechnol. 2005 Aug;23(8):1008-1012.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.
DRAMP03870	RLARIVVIRVAR	12	Bac2A (a linear variant of bovine dodecapeptide)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=50 ?g/ml), Escherichia coli (MIC=17 ?g/ml), Salmonella (MIC=34 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=17 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=17 ?g/ml).##Yeast: Candida albicans (MIC=9 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16041366##17052614	Nat Biotechnol. 2005 Aug;23(8):1008-1012.Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Volkmer-Engert R, Walter T, Hancock RE. Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	High-throughput generation of small antibacterial peptides with improved activity.Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP03871	YQWQRRMRKL	10	"cLf 20-29 (fragment of caprine lalctoferricin, residues 20-29)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=308 ?M), Escherichia coli (wild strain) (MIC>300 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=308 ?M), Enterococcus faecalis ATCC 29212 (MIC>300 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03875	RRWQWRMKKL	10	"bLf 20-29 (fragment of bovine lactoferricin, residues 20-29)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.25 ?M), Escherichia coli (wild strain) (MIC=5.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=15 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03876	RRWWWRWRRW	10	LFB-RW (derivative of bovine lactoferrin with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?M), Escherichia coli (wild strain) (MIC=5.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=11.25 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03877	KKWWWKWKKW	10	LFB-KW (derivative of bovine lactoferrin with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.25 ?M), Escherichia coli (wild strain) (MIC=7.50 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=22.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03878	RRWWRRWRRW	10	LFB-Rwa (derivative of bovine lactoferrin with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?M), Escherichia coli (wild strain) (MIC=5.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=22.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03879	RRFFFRFRRF	10	LFB-RF (derivative of bovine lactoferrin with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=22.5 ?M), Escherichia coli (wild strain) (MIC=15 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15 ?M), Enterococcus faecalis ATCC 29212 (MIC=22.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03880	RRIIIRWRRI	10	LFB-RI (derivative of bovine lactoferrin with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.63 ?M), Escherichia coli (wild strain) (MIC=3.75 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=15 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03881	RRWWWR	6	LFB-6RW (derivative of bovine lactoferrin with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=22.5 ?M), Escherichia coli (wild strain) (MIC=22.5 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=30 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03882	SKCYQWQRRMRKLGA	15	"LFC (fragment of mature caprine lactoferrin, residues 17 to 31)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=252 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>500 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03883	TKCFQWQWNMRKVRG	15	LFH W8 (tryptophan-modified human lactoferricin derivative)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=74 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>500 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03884	SKCYQWQWRMRKLGA	15	LFC W8 (tryptophan-modified caprine lactoferricin derivative)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=174 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>500 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03885	SKCRQWQWKIRRTNP	15	LFP W8 (tryptophan-modified porcine lactoferricin derivative)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=219 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>500 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03886	FKCRRWQWRMKKLGA	15	"LFB (fragment of bovine lalctoferricin, residues 17 to 31)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=24 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=48 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives.
DRAMP03887	AKCRRWQWRMKKLGA	15	"LFB A1 (derivative of LFB, residue substitution with alanine at position 1)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=35 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03888	FACRRWQWRMKKLGA	15	"LFB A2 (derivative of LFB, residue substitution with alanine at position 2)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=40 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03889	FKARRWQWRMKKLGA	15	"LFB A3 (derivative of LFB, residue substitution with alanine at position 3)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=51 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03890	FKCARWQWRMKKLGA	15	"LFB A4 (derivative of LFB, residue substitution with alanine at position 4)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=35 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03891	FKCRAWQWRMKKLGA	15	"LFB A5 (derivative of LFB, residue substitution with alanine at position 5)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=61 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03892	FKCRRWAWRMKKLGA	15	"LFB A7 (derivative of LFB, residue substitution with alanine at position 7)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=15 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=75 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03893	FKCRRWQWAMKKLGA	15	"LFB A9 (derivative of LFB, residue substitution with alanine at position 9)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=28 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03894	FKCRRWQWRAKKLGA	15	"LFB A10 (derivative of LFB, residue substitution with alanine at position 10)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=70 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03895	FKCRRWQWRMAKLGA	15	"LFB A11 (derivative of LFB, residue substitution with alanine at position 11)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=35 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03896	FKCRRWQWRMKALGA	15	"LFB A12 (derivative of LFB, residue substitution with alanine at position 12)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03897	FKCRRWQWRMKKAGA	15	"LFB A13 (derivative of LFB, residue substitution with alanine at position 13)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03898	FKCRRWQWRMKKLAA	15	"LFB A14 (derivative of LFB, residue substitution with alanine at position 14)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=77 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11095180	J Pept Res. 2000 Nov;56(5):265-274.	"Str??m MB, Rekdal O, Svendsen JS."	Antibacterial activity of 15-residue lactoferricin derivatives
DRAMP03899	AKCLRWQWEMRKVGG	15	LFM A1 W8 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=391 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03900	AKCLRWQWAMRKVGG	15	"LFM A1,9 W8 (LFM W8 derivative with residues substitution)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=134 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03901	RKCLRWQWEMRKVGG	15	LFM R1 W8 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=37 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=374 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03902	EKCLRWQWRMRKVGG	15	LFM R9 W8 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03903	AKCLRWQWRMRKVGG	15	LFM A1 R9 W8 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=31 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=257 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03904	RKCLRWQWAMRKVGG	15	LFM A9 R1 W8 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=31 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=257 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03905	RKCLRWQWRMRKVGG	15	"LFM R1,9 W8 (LFM W8 derivative with residues substitution)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=37 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03906	AKCLRWQWEMRKYGG	15	LFM A1 W8 Y13 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=151 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03907	AKCLRWQWAMRKYGG	15	"LFM A1,9 W8 Y13 (LFM W8 derivative with residues substitution)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=88 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03908	RKCLRWQWEMRKYGG	15	LFM R1 W8 Y13 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=19 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=73 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03909	EKCLRWQWRMRKYGG	15	LFM R9 W8 Y13 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=63 ?M)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03910	AKCLRWQWRMRKYGG	15	LFM A1 R9 W8 Y13 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=40 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03911	RKCLRWQWAMRKYGG	15	LFM A9 R1 W8 Y13 (LFM W8 derivative with residues substitution)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03912	RKCLRWQWRMRKYGG	15	"LFM R1,9 W8 Y13 (LFM W8 derivative with residues substitution)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli.	Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11168896	J Pept Res. 2001 Feb;57(2):127-139.	"Str??m MB, Rekdal O, Stensen W, Svendsen JS."	Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
DRAMP03920	KWKLFKKIEKVGQGIGAVLKVLTTGL	26	Cecropin A (1-8)-melittin (1-13)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.7 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Streptococcus pyogenes (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa OT97 (MIC=1 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777	FEBS Lett. 1992 Jan 20;296(2):190-194.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.
DRAMP03921	KWKLFKKIGIGAVLKVLTTGLPALIS	26	Cecropin A (1-8)-melittin (1-18)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.3 ?M), Pseudomonas aeruginosa OT97 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.4 ?M), Bacillus megaterium Bm11 (MIC=0.4 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Streptococcus pyogenes (MIC=2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777	FEBS Lett. 1992 Jan 20;296(2):190-194.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.
DRAMP03922	KWKLFKKIGIGAVLKVLTTG	20	Cecropin A (1-8)-melittin (1-12)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.4 ?M), Pseudomonas aeruginosa OT97 (MIC=0.9 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.3 ?M), Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Streptococcus pyogenes (MIC=0.1 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777	FEBS Lett. 1992 Jan 20;296(2):190-194.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.
DRAMP03923	KWKLFKKIGIGAVLKVLT	18	Cecropin A (1-8)-melittin (1-10)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa OT97 (MIC=3 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.3 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=7 ?M), Streptococcus pyogenes (MIC=0.8 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777	FEBS Lett. 1992 Jan 20;296(2):190-194.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.
DRAMP03924	KWKLFKKGIGAVLKV	15	Cecropin A (1-7)-melittin (1-8)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=4 ?M), Pseudomonas aeruginosa OT97 (MIC=15 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=1.4 ?M), Bacillus megaterium Bm11 (MIC=0.8 ?M), Staphylococcus aureus Cowan 1 (MIC=29 ?M), Streptococcus pyogenes (MIC=0.7 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777	FEBS Lett. 1992 Jan 20;296(2):190-194.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.
DRAMP03925	KWKLFKKGAVLKVLT	15	Cecropin A (1-7)-melittin (3-10)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=3 ?M), Pseudomonas aeruginosa OT97 (MIC=15 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=3 ?M), Bacillus megaterium Bm11 (MIC=0.9 ?M), Staphylococcus aureus Cowan 1 (MIC>200 ?M), Streptococcus pyogenes (MIC=1 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777	FEBS Lett. 1992 Jan 20;296(2):190-194.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.
DRAMP03927	KWKLFKKIGAVLKVL	15	Cecropin A (1-7)-melittin (2-9)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix (1 helices; 10 residues)	Adopts an amphipathic helix almost parallel to the surface of the micelle.	2JMY resolved by NMR.	CAMEL is also a hybrid peptide obtained by combining residues 1-7 of cecropin (CA) and residues 2-9 of melittin (M).	"Gram-negative bacteria: Escherichia coli D21 (MIC=1 ?M), Pseudomonas aeruginosa OT97 (MIC=4 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.5 ?M), Bacillus megaterium Bm11 (MIC=0.7 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Streptococcus pyogenes (MIC=0.5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777##17397158	FEBS Lett. 1992 Jan 20;296(2):190-194.##J Am Chem Soc. 2007 Apr 25;129(16):5228-5234.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG.##Respondek M, Madl T, G?bl C, Golser R, Zangger K."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.##Mapping the orientation of helices in micelle-bound peptides by paramagnetic relaxation waves.
DRAMP03928	KWKLFKKAVLKVLTT	15	Cecropin A (1-7)-melittin (4-11)hybrid peptide (CAM)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.6 ?M), Pseudomonas aeruginosa OT97 (MIC=4 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.6 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=8 ?M), Streptococcus pyogenes (MIC=0.7 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777##20111863	FEBS Lett. 1992 Jan 20;296(2):190-194.##Curr Microbiol. 2010 Sep;61(3):169-175.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG.##Cao Y, Yu RQ, Liu Y, Zhou HX, Song LL, Cao Y, Qiao DR."	"Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.##Design, recombinant expression, and antibacterial activity of the cecropins-melittin hybrid antimicrobial peptides."
DRAMP03929	KWKLFKKVLKVLTTG	15	Cecropin A (1-7)-melittin (5-12)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa OT97 (MIC=2 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.3 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=8 ?M), Streptococcus pyogenes (MIC=0.4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777	FEBS Lett. 1992 Jan 20;296(2):190-194.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.
DRAMP03930	KWKLFKKLKVLTTGL	15	Cecropin A (1-7)-melittin (6-13)hybrid peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MIC=2 ?M), Pseudomonas aeruginosa OT97 (MIC=8 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=51 ?M), Streptococcus pyogenes (MIC=0.4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1733777	FEBS Lett. 1992 Jan 20;296(2):190-194.	"Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG."	Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.
DRAMP03933	IIYCNRRTGKCQRM	14	"I14M (truncated isoform of thanatin, residue 8-21)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-positive bacteria: Aerococcus viridans (MIC=1.2-2.5 ?M), Micrococcus luteus (MIC=5-10 ?M), Bacillus megaterium (MIC=10-20 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=20-40 ?M), Escherichia coli D31 (MIC=20-40 ?M), Klebsiella pneumoniae (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=20-40 ?M), Botrytis cinerea (MIC=10-20 ?M), Alternaria brassicicola (MIC=5-10 ?M), Fusarium culmorum (MIC=20-40 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8577744	Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.	"Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA."	"Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides."
DRAMP03935	VPIIYCNRRTGKCQRM	16	"V16M (truncated isoform of thanatin, residue 6-21)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-positive bacteria: Aerococcus viridans (MIC=1.2-2.5 ?M), Micrococcus luteus (MIC=2.5-5 ?M), Bacillus megaterium (MIC=5-10 ?M), Bacillus subtilis (MIC=20-40 ?M), Pediococcus acidilactici (MIC=20-40 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.6-1.2 ?M), Escherichia coli D31 (MIC=0.6-1.2 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), Enterobacter cloacae (MIC=5-10 ?M), E. carotovora (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=10-20 ?M), Botrytis cinerea (MIC=10-20 ?M), Nectria haematococca (MIC=5-10 ?M), Trichoderma viride (MIC=20-40 ?M), Alternaria brassicicola (MIC=5-10 ?M), Fusarium culmorum (MIC=10-20 ?M), A. pisi (MIC=20-40 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8577744	Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.	"Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA."	"Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides."
DRAMP03936	KPVPIIYCNRRTGKCQRM	18	"K18M (truncated isoform of thanatin, residue 4-21)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-positive bacteria: Aerococcus viridans (MIC=0.6-1.2 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Bacillus subtilis (MIC=20-40 ?M), Pediococcus acidilactici (MIC=20-40 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.3-0.6 ?M), Escherichia coli D31 (MIC=0.3-0.6 ?M), Escherichia coli 1106 (MIC=0.6-1.2 ?M), Salmonella typhimuriumn (MIC=1.2-2.5 ?M), Klebsiella pneumoniae (MIC=1.2-2.5 ?M), Enterobacter cloacae (MIC1.2-2.5 ?M), E. carotovora (MIC=20-40 ?M), Pseudomonas aeruginosa (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=2.5-5 ?M), Botrytis cinerea (MIC=1.2-2.5 ?M), Nectria haematococca (MIC=5-10 ?M), Trichoderma viride (MIC=2.5-5 ?M), Alternaria brassicicola (MIC=2.5-5 ?M), Fusarium culmorum (MIC=5-10 ?M), A. pisi (MIC=10-20 ?M), Fusarium oxysporumn (MIC=20-40 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8577744	Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.	"Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA."	"Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides."
DRAMP03945	LIKIVPAMICAVTKKC	16	Del 1-4 (Ranalexin analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacterium: Staphylococcus aureus (MIC=256 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=256 ?g/ml), Pseudomonas aeruginosa (MIC=256 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8144672	J Biol Chem. 1994 Apr 8;269(14):10849-10855.	"Clark DP, Durell S, Maloy WL, Zasloff M."	"Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin."
DRAMP03947	GGLIKIVPAMICAVTKKC	18	Del 1-2 (Ranalexin analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacterium: Staphylococcus aureus (MIC=256 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC>256 ?g/ml), Pseudomonas aeruginosa (MIC>256 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8144672	J Biol Chem. 1994 Apr 8;269(14):10849-10855.	"Clark DP, Durell S, Maloy WL, Zasloff M."	"Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin."
DRAMP03948	LGGLIKIVPAMICAVTKKC	19	Del 1 (Ranalexin analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacterium: Staphylococcus aureus (MIC=256 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=256 ?g/ml), Pseudomonas aeruginosa (MIC>256 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8144672	J Biol Chem. 1994 Apr 8;269(14):10849-10855.	"Clark DP, Durell S, Maloy WL, Zasloff M."	"Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin."
DRAMP03949	FLGGLIKIVPAMICAVTKK	19	Del 20 (Ranalexin analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacterium: Staphylococcus aureus (MIC=128 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=256 ?g/ml), Pseudomonas aeruginosa (MIC=128 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8144672	J Biol Chem. 1994 Apr 8;269(14):10849-10855.	"Clark DP, Durell S, Maloy WL, Zasloff M."	"Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin."
DRAMP03967	KWKLFKKIPKFLHLAKKF	18	P18 (Cecropin A(1-8)-Magainin 2(1?12) hybrid peptide analogue)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Alpha helix 	Not found	None	MOA: P18 kills cancer cells by disrupting membranes (Tang C et al 2010 Org Biomol Che 8:984-7). 	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=1.56 ?M), Bacillus megaterium KCTC 1096 (MIC=0.78 ?M).##Tumor cells: MDA-MB-361 (IC50=8.0 ?M), Jurkat (IC50=4.0 ?M), K-562 (IC50=3.5 ?M), Normal cells NIH 3T3 (IC50=75.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	12005420##12370027	J Pept Res. 2001 Dec;58(6):504-514.##Protein Pept Lett. 2002 Oct;9(5):395-402.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI.##Lee SH, Lee DG, Yang ST, Kim Y, Kim JI, Hahm KS, Shin SY."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs.##Antibiotic activity of reversed peptides of alpha-helical antimicrobial peptide, P18."
DRAMP03968	KWKLFKKILKFLHLAKKF	18	[L9]-P18 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 ?M), Proteus vulgaris (MIC=6.25 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=3.0 ?M), Jurkat (IC50=9.0 ?M), K-562 (IC50=3.0 ?M), Normal cells NIH 3T3 (IC50=70.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03969	KWKLFKKISKFLHLAKKF	18	[S9]-P18 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=25.0 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=6.25 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=4.0 ?M), Jurkat (IC50=7.0 ?M), K-562 (IC50=3.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03970	WKLFKKIPKFLHLAKKF	17	N-1 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=9.5 ?M), Jurkat (IC50=12.0 ?M), K-562 (IC50=6.0 ?M), Normal cells NIH 3T3 (IC50=75.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03971	FKLFKKIPKFLHLAKKF	17	N-2 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=0.78 ?M).##Tumor cells: MDA-MB-361 (IC50=11.0 ?M), Jurkat (IC50=11.0 ?M), K-562 (IC50=7.0 ?M), Normal cells NIH 3T3 (IC50=70.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03972	KWFKKIPKFLHLAKKF	16	N-3 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=17.0 ?M), Jurkat (IC50=17.0 ?M), K-562 (IC50=11.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03973	WFKKIPKFLHLAKKF	15	N-4 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=32.0 ?M), Jurkat (IC50=23.0 ?M), K-562 (IC50=24.0 ?M), Normal cells NIH 3T3 (IC50=100.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03974	WKKIPKFLHLAKKF	14	N-5 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03975	KWFKKIPKFLHLLKKF	16	N-3L (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=3.125 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=1.56 ?M), Bacillus megaterium KCTC 1096 (MIC=0.78 ?M).##Tumor cells: MDA-MB-361 (IC50=5.0 ?M), Jurkat (IC50=4.0 ?M), K-562 (IC50=4.2 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03976	WFKKIPKFLHLLKKF	15	N-4L (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=3.125 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=12.5 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=0.78 ?M).##Tumor cells: MDA-MB-361 (IC50=5.0 ?M), Jurkat (IC50=6.0 ?M), K-562 (IC50=3.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03977	WKKIPKFLHLLKKF	14	N-5L (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 ?M), Proteus vulgaris (MIC=12.5 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=17.0 ?M), Jurkat (IC50=14.0 ?M), K-562 (IC50=10.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03978	KWKLFKKIPFLHLAKKF	17	C-1 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=26.0 ?M), Jurkat (IC50=32.0 ?M), K-562 (IC50=31.0 ?M), Normal cells NIH 3T3 (IC50=100.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03979	KWKLFKKIPKFLHLAKK	17	C-2 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=38.0 ?M), Jurkat (IC50=26.0 ?M), K-562 (IC50=23.0 ?M), Normal cells NIH 3T3 (IC50=100.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03980	KWKLFKKIPLHLAKKF	16	C-3 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25-12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78-1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=79.0 ?M), Jurkat (IC50=74.0 ?M), K-562 (IC50=62.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03981	KWKLFKKIPKFLHLAK	16	C-4 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=3.125-6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=54.0 ?M), Jurkat (IC50=31.0 ?M), K-562 (IC50=25.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03982	KWKLFKKIPHLAKKF	15	C-5 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=12.5 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=100.0 ?M), Jurkat (IC50=81.0 ?M), K-562 (IC50=67.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03983	KWKLFKKIPKFLHLA	15	C-6 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25-12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=47.0 ?M), Jurkat (IC50=21.0 ?M), K-562 (IC50=27.0 ?M), Normal cells NIH 3T3 (IC50=100.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03984	KWKLFKKIPLAKKF	14	C-7 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25-12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=12.5 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03985	KWKLFKKIPKFLHL	14	C-8 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=83.0 ?M), Jurkat (IC50=54.0 ?M), K-562 (IC50=30.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03986	KWKLFKKIPLKKF	13	C-9 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=12.5 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=12.5 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03987	KWKLFKKIPKFLH	13	C-10 (analog of P18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25-12.5 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005420	J Pept Res. 2001 Dec;58(6):504-514.	"Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs."
DRAMP03990	LLKWLKKL	8	L4K3W4 (LlKmWn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=50 ?g/ml), Staphylococcus aureus ATCC 6538p (MIC=25 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa ATCC 27853 (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19544481	J Pept Sci. 2009 Sep;15(9):583-588.	"Kang SJ, Won HS, Choi WS, Lee BJ."	De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface.
DRAMP03992	KLLKWLLKL	9	L5K3W5 (LlKmWn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=12.5 ?g/ml), Staphylococcus aureus ATCC 6538p (MIC=3.1 ?g/ml), Staphylococcus epidermis ATCC 12228 (MIC=12.5 ?g/ml), Micrococcus luteus ATCC 10240 (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 ?g/ml), Shigella dysentariae ATCC 9752 (MIC=12.5 ?g/ml), Salmonella typhomurium ATCC 14028 (MIC=25 ?g/ml), Klebsiella pneumoniae ATCC 10031 (MIC=6.3 ?g/ml), Pseudomonas aeruginosa ATCC 27 853 (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19544481	J Pept Sci. 2009 Sep;15(9):583-588.	"Kang SJ, Won HS, Choi WS, Lee BJ."	De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface.
DRAMP03993	KKLLKWLKKLL	11	L5K5W6 (LlKmWn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=6.3 ?g/ml), Staphylococcus aureus ATCC 6538p (MIC=6.3 ?g/ml), Staphylococcus epidermis ATCC 12228 (MIC=6.3 ?g/ml), Micrococcus luteus ATCC 10240 (MIC=6.3 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 ?g/ml), Shigella dysentariae ATCC 9752 (MIC=6.3 ?g/ml), Salmonella typhomurium ATCC 14028 (MIC=25 ?g/ml), Klebsiella pneumoniae ATCC 10031 (MIC=6.3 ?g/ml), Pseudomonas aeruginosa ATCC 27 853 (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19544481	J Pept Sci. 2009 Sep;15(9):583-588.	"Kang SJ, Won HS, Choi WS, Lee BJ."	De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface.
DRAMP03994	KKLLKWLLKLL	11	L6K4W6 (LlKmWn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=1.6 ?g/ml), Staphylococcus aureus ATCC 6538p (MIC=1.6 ?g/ml), Staphylococcus epidermis ATCC 12228 (MIC=1.6 ?g/ml), Micrococcus luteus ATCC 10240 (MIC=1.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Shigella dysentariae ATCC 9752 (MIC=3.1 ?g/ml), Salmonella typhomurium ATCC 14028 (MIC=25 ?g/ml), Klebsiella pneumoniae ATCC 10031 (MIC=3.1 ?g/ml), Pseudomonas aeruginosa ATCC 27 853 (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19544481	J Pept Sci. 2009 Sep;15(9):583-588.	"Kang SJ, Won HS, Choi WS, Lee BJ."	De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface.
DRAMP03995	LKLLKWLLKLL	11	L7K3W6 (LlKmWn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=1.6 ?g/ml), Staphylococcus aureus ATCC 6538p (MIC=3.1 ?g/ml), Staphylococcus epidermis ATCC 12228 (MIC=3.1 ?g/ml), Micrococcus luteus ATCC 10240 (MIC=3.1 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=50 ?g/ml), Shigella dysentariae ATCC 9752 (MIC=12.5 ?g/ml), Klebsiella pneumoniae ATCC 10031 (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19544481	J Pept Sci. 2009 Sep;15(9):583-588.	"Kang SJ, Won HS, Choi WS, Lee BJ."	De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface.
DRAMP03999	ILGKIAEGIKSLF	13	[A6]-IsCT (Mutant: W6A; IsCT analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: [A6]-IsCT did not cause any hemolysis at peptide concentrations as high as 100 ?M, indicating that Trp6 is important for both the hemolytic activity and antibacterial activity of IsCT.
Chemical modification: C-terminal amidation."	"[Ref.15369808]Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=64 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=32 ?M), Salmonella typhimurium KCTC 1926 (MIC>64 ?M);##Gram-positive bacteria: Staphylococcus epidermidis KCTC 1917 (MIC>64 ?M), Staphylococcus aureus KCTC 1621 (MIC>64 ?M)."	[Ref.15369808]Non-hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15369808	Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-719.	"Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y."	Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs.
DRAMP04000	ILGKILEGIKSLF	13	[L6]-IsCT (Mutant: W6L; IsCT analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Drastic reduction in antibacterial activity against both Gram-positive and Gram-negative bacteria, and big loss of hemolysis activity.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=16 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=16 ?M), Salmonella typhimurium KCTC 1926 (MIC=16 ?M);##Gram-positive bacteria: Staphylococcus epidermidis KCTC 1917 (MIC=32 ?M), Staphylococcus aureus KCTC 1621 (MIC=4 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15369808	Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-719.	"Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y."	Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs.
DRAMP04001	ILGKIWKGIKSLF	13	[K7]-IsCT (Mutant: E7K; IsCT analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: [K7]-IsCT displays a similar or 2-fold increase in antibacterial activity against both Gram-positive and Gram-negative bacteria, and complete loss of hemolysis activity.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=2 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=2 ?M), Salmonella typhimurium KCTC 1926 (MIC=1 ?M);##Gram-positive bacteria: Staphylococcus epidermidis KCTC 1917 (MIC=1 ?M), Staphylococcus aureus KCTC 1621 (MIC=1 ?M)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15369808	Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-719.	"Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y."	Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs.
DRAMP04002	ILGKILKGIKKLF	13	"[L6, K11]-IsCT (IsCT analog through amino acids substitution)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: [L6, K11]-IsCT displays a similar or 2-fold higher antibacterial activity relative to that of native IsCT.
Chemical modification: C-terminal amidation."	"Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=2 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=2 ?M), Salmonella typhimurium KCTC 1926 (MIC=1 ?M);##Gram-positive bacteria: Staphylococcus epidermidis KCTC 1917 (MIC=1 ?M), Staphylococcus aureus KCTC 1621 (MIC=2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15369808	Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-719.	"Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y."	Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs.
DRAMP04003	ILGKIWKIKKLF	12	"[K7, P8, K11]-IsCT (IsCT analog through amino acids substitution)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: [K7, P8, K11]-IsCT exhibited more potent antibacterial activity than native IsCT but no hemolytic activity, even at concentrations as high as 100 ?M. [K7, P8, K11]-IsCT displays a similar or 2-fold higher antibacterial activity relative to that of native IsCT.
Chemical modification: C-terminal amidation."	"[Ref.15369808]Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=2 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=2 ?M), Salmonella typhimurium KCTC 1926 (MIC=1 ?M);##Gram-positive bacteria: Staphylococcus epidermidis KCTC 1917 (MIC=1 ?M), Staphylococcus aureus KCTC 1621 (MIC=2 ?M);##Antibiotic-resistant bacteria: Methicillin-resistant Staphylococcus aureus (MRSA) CCARM 3001 (MIC=1 ?M), multidrug-resistant Pseudomonas aeruginosa (MDRPA) (CCARM 3543) (MIC=1 ?M) and multidrug-resistant Pseudomonas aeruginosa (MDRPA) CCARM 2095 (MIC=1 ?M)."	[Ref.15369808]Non-hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15369808	Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-719.	"Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y."	Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs.
DRAMP04004	VSLFPVXLFP	10	Gramicidin analogue ([Scr2]-GS)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Staphylococcus aureus ATCC 6538 P(MIC=25 ?g/ml), Streptococcus pyogenes N.Y.5 (MIC=25 ?g/ml), Myotis flavus ATCC 10240 (MIC=3.1 ?g/ml), Bacillus subtilis ATCC 6633 (MIC=6.3 ?g/ml);##Gram-negative bacteria: Corynebacterium diphtheriae P.W.8 (MIC=3.1 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8791160	Int J Pept Protein Res. 1996 May;47(5):369-375.	"Tamaki M, Akabori S, Muramatsu I."	Properties of synthetic analogs of gramicidin S containing L-serine or L-glutamic acid residue in place of L-ornithine residue.
DRAMP04005	VSLFPVSLFP	10	"Gramicidin analogue ([Ser2,2']-GS)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Streptococcus pyogenes N.Y.5 (MIC=25 ?g/ml), Myotis flavus ATCC 10240 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Corynebacterium diphtheriae P.W.8 (MIC=12.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8791160	Int J Pept Protein Res. 1996 May;47(5):369-375.	"Tamaki M, Akabori S, Muramatsu I."	Properties of synthetic analogs of gramicidin S containing L-serine or L-glutamic acid residue in place of L-ornithine residue.
DRAMP04011	GVVTDLLKTAGKLLGNLFGSLSG	23	Plasticin PD36 KF (analog of PD36)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy. The hemolytic activity of the peptides was determined using fresh rat erythrocytes.	"[Ref.17128968]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6.5 ?M), Bacillus megaterium ATCC 9885 (MIC=50.25 ?M);##Gram-negative bacteria: Escherichia coli ATCC 11775 (MIC=6.5 ?M), Salmonella typhimurium CIP 6062 (MIC=25.25 ?M), Enterobacter cloacae ATCC 11775 (MIC=12.5 ?M)."	"[Ref.17128968]25% hemolytic at 50 ¦ÌM, 50% hemolytic activity at 100 ¦ÌM against rat red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17128968	Biochemistry 2006; 45: 14285-14297.	Amri CE et al Bruston F.	"The plasticins: membrane adsortpion, lipid disorders, and biological activity."
DRAMP04012	GVVTDLLKTAGKLLGNLVGSLSG	23	Plasticin PD36 K (analog of PD36)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy. The hemolytic activity of the peptides was determined using fresh rat erythrocytes.	"[Ref.17128968]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=50.5 ?M), Bacillus megaterium ATCC 9885 (MIC=12.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC 11775 (MIC=12.5 ?M)."	"[Ref.17128968]35% hemolytic at 50 ¦ÌM, 71% hemolytic activity at 100 ¦ÌM against rat red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17128968	Biochemistry 2006; 45: 14285-14297.	Amri CE et al Bruston F.	"The plasticins: membrane adsortpion, lipid disorders, and biological activity."
DRAMP04013	GLVTGLLKTAGKLLGDLFGSLTG	23	Plasticin ANC KF (analog of natural peptide ANC)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy. The hemolytic activity of the peptides was determined using fresh rat erythrocytes.	"[Ref.17128968]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=12.5 ?M), Bacillus megaterium ATCC 9885 (MIC=12.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC 11775 (MIC=25 ?M)."	"[Ref.17128968]22% hemolytic at 50 ¦ÌM, 48% hemolytic activity at 100 ¦ÌM against rat red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17128968	Biochemistry 2006; 45: 14285-14297.	Amri CE et al Bruston F.	"The plasticins: membrane adsortpion, lipid disorders, and biological activity."
DRAMP04014	LLGDFFRKAKEKIGKEFKRIVQRIKDFLRNLVPRTES	37	LL-37A9 (LL-37 variants)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against the Gram-negative bacterium E. coli.	"Gram-negative bacteria: Escherichia coli DC2 (MIC=6 ?M), Escherichia coli K12 (MIC=15 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22185690	Biochemistry. 2012 Jan 17;51(2):653-664. 	"Wang G, Elliott M, Cogen AL, Ezell EL, Gallo RL, Hancock RE."	"Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins."
DRAMP04015	LLGDFFRKVKEKIGKEFKRIVQRIKDFLRNLVPRTES	37	LL-37V9 (LL-37 variants)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against the Gram-negative bacterium E. coli.	"Gram-negative bacteria: Escherichia coli DC2 (MIC=12 ?M), Escherichia coli K12 (MIC=25 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22185690	Biochemistry. 2012 Jan 17;51(2):653-664. 	"Wang G, Elliott M, Cogen AL, Ezell EL, Gallo RL, Hancock RE."	"Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins."
DRAMP04017	LLGDFFRKVKEKIGKEFKRIVQR	23	LL-23V9 (LL-23 variants)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli DC2 (MIC=2 ?M), Escherichia coli K12 (MIC=40 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?M), S. aureus mprF (presence of carbonate) (MIC=0.35-0.7 ?M), S. aureus mprF (absence of carbonate) (MIC=6 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22185690	Biochemistry. 2012 Jan 17;51(2):653-664. 	"Wang G, Elliott M, Cogen AL, Ezell EL, Gallo RL, Hancock RE."	"Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins."
DRAMP04019	RAVAVIIRLRRV	12	Bac014 (Scrambled Variants of Bac2A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=23 ?g/ml), Escherichia coli (MIC=11 ?g/ml), Salmonella (MIC=11 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=23 ?g/ml), Staphylococcus epidermidis (MIC=6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04020	RRAAVVLIVIRR	12	Bac020 (Scrambled Variants of Bac2A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=11 ?g/ml), Escherichia coli (MIC=6 ?g/ml), Salmonella (MIC=23 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=11 ?g/ml), Staphylococcus epidermidis (MIC=1.5 ?g/ml).##Yeast: Candida albicans (MIC=11 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04021	VRLRIRVAVIRA	12	Bac034 (Scrambled Variants of Bac2A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=25 ?g/ml), Escherichia coli (MIC=3 ?g/ml), Salmonella (MIC=12 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermidis (MIC=3 ?g/ml).##Yeast: Candida albicans (MIC=12 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04022	VRFRIRVAVIRA	12	"F3 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04023	VRWRIRVAVIRA	12	"W3 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=12 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04024	VRLWIRVAVIRA	12	"W4 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC>50 ?g/ml), Escherichia coli (MIC=6 ?g/ml), Salmonella (MIC>50 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?g/ml), Staphylococcus epidermidis (MIC=3 ?g/ml).##Yeast: Candida albicans (MIC=50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04025	VRLRIRVAVRRA	12	"R10 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=12 ?g/ml), Escherichia coli (MIC=6 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04026	VRLRIRVAVIRK	12	"K12 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=3 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=3 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04027	VQLRIRVRVIRK	12	"opt1 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=3 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04028	VRLRIRVRVIRK	12	"opt2 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=3 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=0.8 ?g/ml).##Yeast: Candida albicans (MIC=3 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04029	KQFRIRVRVIRK	12	"opt3 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=3 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04030	KRFRIRVRVIRK	12	"opt4 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=3 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=0.8 ?g/ml).##Yeast: Candida albicans (MIC=12 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04031	KRWRIRVRVIRK	12	"opt5 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (MIC=3 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=3 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?g/ml), Staphylococcus epidermidis (MIC=0.8 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17052614	Chem Biol. 2006 Oct;13(10):1101-1107.	"Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE."	Sequence requirements and an optimization strategy for short antimicrobial peptides.
DRAMP04032	ALRLAIRKR	9	Modified defensin	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=5 ?g/ml), Staphylococcus aureus (MRSA) (MIC>48 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=4 ?g/ml), Pseudomonas aeruginosa (MIC=15 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10561605	Eur J Biochem. 1999 Dec;266(2):616-623.	"Ishibashi J, Saido-Sakanaka H, Yang J, Sagisaka A, Yamakawa M."	"Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros."
DRAMP04033	ALLLAIRKR	9	Modified defensin	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) (MIC=40 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=6 ?g/ml), Pseudomonas aeruginosa (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10561605	Eur J Biochem. 1999 Dec;266(2):616-623.	"Ishibashi J, Saido-Sakanaka H, Yang J, Sagisaka A, Yamakawa M."	"Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros."
DRAMP04034	AWLLAIRKR	9	Modified defensin	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?g/ml), Staphylococcus aureus (MRSA) (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=5 ?g/ml), Pseudomonas aeruginosa (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10561605	Eur J Biochem. 1999 Dec;266(2):616-623.	"Ishibashi J, Saido-Sakanaka H, Yang J, Sagisaka A, Yamakawa M."	"Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros."
DRAMP04035	ALYLAIRKR	9	Modified defensin	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?g/ml), Staphylococcus aureus (MRSA) (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=4 ?g/ml), Pseudomonas aeruginosa (MIC=4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10561605	Eur J Biochem. 1999 Dec;266(2):616-623.	"Ishibashi J, Saido-Sakanaka H, Yang J, Sagisaka A, Yamakawa M."	"Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros."
DRAMP04036	ALWLAIRKR	9	Modified defensin	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) (MIC=40 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=10 ?g/ml), Pseudomonas aeruginosa (MIC=10 ?g/ml). "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10561605	Eur J Biochem. 1999 Dec;266(2):616-623.	"Ishibashi J, Saido-Sakanaka H, Yang J, Sagisaka A, Yamakawa M."	"Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros."
DRAMP04048	RRLCRIVVIRVCRR	14	BacR (cyclic derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=2 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Salmonella typhimurium 14028s (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=64 ?g/ml), Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC=32 ?g/ml), Listeria monocytogenes (MIC<0.125 ?g/ml), Corynebacterium xerosis (MIC=1 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=8 ?g/ml), S. mitis (MIC=0.5 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys4 and Cys12.	L	No cytotoxicity information found	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04049	RRRCPIVVIRVCRR	14	BacP3R (cyclic derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=2 ?g/ml), Pseudomonas aeruginosa K799 (MIC=8 ?g/ml), Salmonella typhimurium 14028s (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>64 ?g/ml), Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC=32 ?g/ml), Listeria monocytogenes (MIC+0.5 ?g/ml), Corynebacterium xerosis (MIC=4 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=8 ?g/ml), S. mitis (MIC=1 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys4 and Cys12.	L	No cytotoxicity information found	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04050	RRRLCPIVIRVCRR	14	BacP3R-V (cyclic derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=2 ?g/ml), Pseudomonas aeruginosa K799 (MIC=8 ?g/ml), Salmonella typhimurium 14028s (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>64 ?g/ml), Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC>64 ?g/ml), Listeria monocytogenes (MIC=1 ?g/ml), Corynebacterium xerosis (MIC=4 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=4 ?g/ml), S. mitis (MIC=1 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys5 and Cys12.	L	No cytotoxicity information found	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04051	RICRIVVIRCIR	12	Bac2I-NH2 (cyclic derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=4 ?g/ml), Pseudomonas aeruginosa K799 (MIC=16 ?g/ml), Salmonella typhimurium 14028s (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 ?g/ml), Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC>32 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Amidation 	Disulfide bond between Cys3 and Cys10.	L	No cytotoxicity information found	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04052	RLCPRVRIRVCR	12	BacP2R-NH2 (cyclic derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=4 ?g/ml), Pseudomonas aeruginosa K799 (MIC=16 ?g/ml), Salmonella typhimurium 14028s (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>32 ?g/ml), Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC>32 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Amidation 	Disulfide bond between Cys3 and Cys11.	L	No cytotoxicity information found	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04053	RLCRIVPVIRVCR	13	BacP1 (cyclic derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=32 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Salmonella typhimurium 14028s (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=64 ?g/ml), Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC>64 ?g/ml), Listeria monocytogenes (MIC=2 ?g/ml), Corynebacterium xerosis (MIC=8 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=64 ?g/ml), S. mitis (MIC=4 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys12.	L	No cytotoxicity information found	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04054	RLCRIVWVIRVCR	13	BacW (cyclic derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Salmonella typhimurium 14028s (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4 ?g/ml), Staphylococcus epidermidis C621 (MIC=2 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC=8 ?g/ml), Listeria monocytogenes (MIC=0.5 ?g/ml), Corynebacterium xerosis (MIC=1 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=2 ?g/ml), S. mitis (MIC=1 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC=16 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04055	RRLCRIVWVIRVCRR	15	BacW2R (cyclic derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=2 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), Salmonella typhimurium 14028s (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?g/ml), Staphylococcus epidermidis C621 (MIC=1 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC=2 ?g/ml), Listeria monocytogenes (MIC=0.25 ?g/ml), Corynebacterium xerosis (MIC=0.25 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=1 ?g/ml), S. mitis (MIC=0.25 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04056	RLSRIVVIRVSR	12	Lin Bac2S-NH2 (linear derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=2 ?g/ml), Pseudomonas aeruginosa K799 (MIC=16 ?g/ml), Salmonella typhimurium 14028s (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4 ?g/ml), Staphylococcus epidermidis C621 (MIC=1 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC=4 ?g/ml), Listeria monocytogenes (MIC=0.25 ?g/ml), Corynebacterium xerosis (MIC=0.25 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=2 ?g/ml), S. mitis (MIC=0.125 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC=16 ?g/ml)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04057	RLSRIVVIRVCR	12	Lin BacS-NH2 (linear derivative of bactenecin)	No entry found	Not found	Not found	Synthetic construct 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli K-12 (MIC=4 ?g/ml), Pseudomonas aeruginosa K799 (MIC=16 ?g/ml), Salmonella typhimurium 14028s (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=16 ?g/ml), Staphylococcus epidermidis C621 (MIC=2 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC=16 ?g/ml), Listeria monocytogenes (MIC=0.5 ?g/ml), Corynebacterium xerosis (MIC=0.5 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=8 ?g/ml), S. mitis (MIC=0.5 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC=8 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10223951	Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.	"Wu M, Hancock RE."	"Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide."
DRAMP04064	CVKCKCKCGSGVKVKVKVC	19	Cyclic cationic V1 peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activiy. Has hemolytic activity against human erythrocytes, and also Cytotoxic activity against THP-1 cells (EC50=0.045 mM)."	"[Ref.15328096]Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=5 nM), Pseudomonas aeruginosa ATTC 27853 (MIC>619 nM), Klebsiella pneumoniae ATTC 13883 (MIC=145 nM), Salmonella enterica serovar Typhimurium ATTC 14028 (MIC=5 nM), Shigella sonnei ATTC 25931 (MIC=5 nM)."	[Ref.15328096]EC50=880000 nM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15328096	Antimicrob Agents Chemother. 2004 Sep;48(9):3349-3357.	"Frecer V, Ho B, Ding JL."	De Novo Design of Potent Antimicrobial Peptides.
DRAMP04065	CVKVSVKVGSGVKVSVKVC	19	Cyclic cationic V2 peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activiy. Has hemolytic activity for human erythrocytes, and also Cytotoxic activity for THP-1 cells (EC50=5.6 mM)."	"[Ref.15328096]Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=5 nM), Pseudomonas aeruginosa ATTC 27853 (MIC>643 nM), Klebsiella pneumoniae ATTC 13883 (MIC=643 nM), Salmonella enterica serovar Typhimurium ATTC 14028 (MIC=5 nM), Shigella sonnei ATTC 25931 (MIC=5 nM)."	[Ref.15328096]EC50=589000 nM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15328096	Antimicrob Agents Chemother. 2004 Sep;48(9):3349-3357.	"Frecer V, Ho B, Ding JL."	De Novo Design of Potent Antimicrobial Peptides.
DRAMP04066	CVKVRVKVGSGVKVRVKVC	19	Cyclic cationic V3 peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activiy. Has hemolytic activity for human erythrocytes, and also Cytotoxic activity for THP-1 cells (EC50=0.042 mM)."	"[Ref.15328096]Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=300 nM), Pseudomonas aeruginosa ATTC 27853 (MIC=5 nM), Klebsiella pneumoniae ATTC 13883 (MIC=10 nM), Salmonella enterica serovar Typhimurium ATTC 14028 (MIC=300 nM), Shigella sonnei ATTC 25931 (MIC=5 nM)."	[Ref.15328096]EC50=590000 nM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15328096	Antimicrob Agents Chemother. 2004 Sep;48(9):3349-3357.	"Frecer V, Ho B, Ding JL."	De Novo Design of Potent Antimicrobial Peptides.
DRAMP04067	CVKVQVKVGSGVKVQVKVC	19	Cyclic cationic V4 peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activiy. Has hemolytic activity for human erythrocytes, and also Cytotoxic activity for THP-1 cells (EC50=0.047 mM)."	"[Ref.15328096]Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=10 nM), Pseudomonas aeruginosa ATTC 27853 (MIC=5 nM), Klebsiella pneumoniae ATTC 13883 (MIC<5 nM), Salmonella enterica serovar Typhimurium ATTC 14028 (MIC=5 nM), Shigella sonnei ATTC 25931 (MIC=10 nM)."	[Ref.15328096]EC50=3226000 nM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15328096	Antimicrob Agents Chemother. 2004 Sep;48(9):3349-3357.	"Frecer V, Ho B, Ding JL."	De Novo Design of Potent Antimicrobial Peptides.
DRAMP04068	CAKAKAKAGSGAKAKAKAC	19	Cyclic cationic V5 peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activiy. Has hemolytic activity for human erythrocytes, and also Cytotoxic activity for THP-1 cells (EC50=0.14 mM)."	"[Ref.15328096]Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=173 nM), Pseudomonas aeruginosa ATTC 27853 (MIC=5 nM), Klebsiella pneumoniae ATTC 13883 (MIC>692 nM), Salmonella enterica serovar Typhimurium ATTC 14028 (MIC=5 nM), Shigella sonnei ATTC 25931 (MIC=692 nM)."	[Ref.15328096]EC50=1055000 nM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15328096	Antimicrob Agents Chemother. 2004 Sep;48(9):3349-3357.	"Frecer V, Ho B, Ding JL."	De Novo Design of Potent Antimicrobial Peptides.
DRAMP04069	CFKFKFKFGSGFKFKFKFC	19	Cyclic cationic V6 peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activiy. Has hemolytic activity for human erythrocytes, and also Cytotoxic activity for THP-1 cells (EC50=0.045 mM)."	"[Ref.15328096]Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=518 nM), Pseudomonas aeruginosa ATTC 27853 (MIC=4 nM), Klebsiella pneumoniae ATTC 13883 (MIC=4 nM), Salmonella enterica serovar Typhimurium ATTC 14028 (MIC=528 nM), Shigella sonnei ATTC 25931 (MIC=4 nM)."	[Ref.15328096]EC50=35000 nM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15328096	Antimicrob Agents Chemother. 2004 Sep;48(9):3349-3357.	"Frecer V, Ho B, Ding JL."	De Novo Design of Potent Antimicrobial Peptides.
DRAMP04070	CWKWKWKWGSGWKWKWKWC	19	Cyclic cationic V7 peptide	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activiy. Has hemolytic activity for human erythrocytes, and also Cytotoxic activity for THP-1 cells (EC50=0.085 mM)."	"[Ref.15328096]Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=114 nM), Pseudomonas aeruginosa ATTC 27853 (MIC=4 nM), Klebsiella pneumoniae ATTC 13883 (MIC=458 nM), Salmonella enterica serovar Typhimurium ATTC 14028 (MIC=4 nM), Shigella sonnei ATTC 25931 (MIC=7 nM)."	[Ref.15328096]EC50=45000 nM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15328096	Antimicrob Agents Chemother. 2004 Sep;48(9):3349-3357.	"Frecer V, Ho B, Ding JL."	De Novo Design of Potent Antimicrobial Peptides.
DRAMP04075	AKKVFKRLEKLFSKIQNDK	19	Antimicrobial peptide HP (2-20)	P56029	Not found	rplA	Synthetic construct (amino acid substitution)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix (1 helices; 11 residues)	Not found	1P0G resolved by NMR.	Function: Peptides originating from the N-terminal end of L1 have antibacterial activity against bacteria such as E. coli and Bacillus megaterium and modest antifungal activities. Has no effect on H. pylori itself. Peptides are not hemolytic against mammalian cells. These peptides may be released in the stomach during altruistic lysis to kill other fast growing bacteria.	"[Ref.16255716]Gram-positive bacteria: Bacillus subtilis (MIC=3.13 ?g/ml), Staphylococcus epidermidis (MIC=6.25 ?g/ml), Staphylococcus aureus (MIC=12.5 ?g/ml), Listeria monocytogenes (MIC=6.25 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ?g/ml), Salmonella typhimurium (MIC=1.56 ?g/ml), Proteus vulgaris (MIC=6.25 ?g/ml), Pseudomonas aeruginosa (MIC=6.25 ?g/ml), Escherichia coli O157 (MIC=12.5 ?g/ml);##Fungi: Trichosporon beigelii (MIC=3.13 ?g/ml), Candida albicans (MIC>25 ?g/ml), Saccharomyces cerevisiae (MIC>25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC=12.5 ?g/ml), Fusarium moniliforme (MIC=25 ?g/ml)."	[Swiss_Prot Entry P56029]Non-hemolytic against mammalian cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Phospholipids	16255716##PubMed ID is not available##PubMed ID is not available	Biochem J. 2006 Feb 15;394(Pt 1):105-114.##Submitted (SEP-2004) to the PDB data bank.##To be published	"Lee KH, Lee DG, Park YK, Harm KS, Kim YM.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM."	"Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Structure of antimicrobial peptide, HP (2-20) and its analogues derived from Helicobacter pylori, as determined by 1H NMR spectroscopy.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy."
DRAMP04076	AKKVFKRLEKLFSKIQNWK	19	Anal 1 (antimicrobial peptide HP (2-20)analogue)	P56029	Not found	Not found	Synthetic construct (amino acid substitution)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix (1 helices; 14 residues)	Not found	1P0J resolved by NMR.	Function: Has antibacterial and antifungal activiy. 	"Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=3.13 ?g/ml), Staphylococcus aureus (MIC=3.13 ?g/ml), Listeria monocytogenes (MIC=0.78 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=0.78 ?g/ml), Salmonella typhimurium (MIC=0.39 ?g/ml), Proteus vulgaris (MIC=3.13 ?g/ml), Pseudomonas aeruginosa (MIC=3.13 ?g/ml), Escherichia coli O157 (MIC=6.25 ?g/ml).##Fungi: Trichosporon beigelii (MIC=1.56 ?g/ml), Candida albicans (MIC=25 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC=6.25 ?g/ml), Fusarium moniliforme (MIC=12.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16255716##PubMed ID is not available	Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published	"Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM."	"Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy."
DRAMP04077	AKKVFKRLEKLFSKIWNDK	19	Anal 2 (antimicrobial peptide HP (2-20)analogue)	P56029	Not found	Not found	Synthetic construct (amino acid substitution)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix (1 helices; 14 residues)	Not found	1P0L resolved by NMR.	Function: Has antibacterial and antifungal activiy. 	"Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=3.13 ?g/ml), Staphylococcus aureus (MIC=6.25 ?g/ml), Listeria monocytogenes (MIC=1.56 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ?g/ml), Salmonella typhimurium (MIC=0.78 ?g/ml), Proteus vulgaris (MIC=3.13 ?g/ml), Pseudomonas aeruginosa (MIC=6.25 ?g/ml), Escherichia coli O157 (MIC=6.25 ?g/ml).##Fungi: Trichosporon beigelii (MIC=1.56 ?g/ml), Candida albicans (MIC=25 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC=6.25 ?g/ml), Fusarium moniliforme (MIC=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16255716##PubMed ID is not available	Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published	"Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM."	"Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy."
DRAMP04078	AKKVFKRLEKLFSKIWNWK	19	Anal 3 (antimicrobial peptide HP (2-20)analogue)	P56029	Not found	Not found	Synthetic construct (amino acid substitution)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix (1 helices; 14 residues)	Not found	1P0O resolved by NMR.	Function: Has antibacterial and antifungal activiy. 	"Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=3.13 ?g/ml), Staphylococcus aureus (MIC=1.56 ?g/ml), Listeria monocytogenes (MIC=0.39 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=1.56 ?g/ml), Salmonella typhimurium (MIC=0.39 ?g/ml), Proteus vulgaris (MIC=3.13 ?g/ml), Pseudomonas aeruginosa (MIC=3.13 ?g/ml), Escherichia coli O157 (MIC=3.13 ?g/ml).##Fungi: Trichosporon beigelii (MIC=1.56 ?g/ml), Candida albicans (MIC=12.5 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=25 ?g/ml), Aspergillus fumigatus (MIC=25 ?g/ml), Botrytis cinerea (MIC=3.13 ?g/ml), Fusarium moniliforme (MIC=12.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16255716##PubMed ID is not available	Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published	"Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM."	"Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy."
DRAMP04079	AKKVFKRLEKSFSKIQNDK	19	Anal 4 (antimicrobial peptide HP (2-20)analogue)	P56029	Not found	Not found	Synthetic construct (amino acid substitution)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix (1 helices; 13 residues)	Not found	1P5K resolved by NMR.	Function: Has antibacterial and antifungal activiy. 	"Gram-positive bacteria: Bacillus subtilis (MIC=6.25 ?g/ml), Staphylococcus epidermidis (MIC>12.5 ?g/ml), Staphylococcus aureus (MIC>12.5 ?g/ml), Listeria monocytogenes (MIC>12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=12.5 ?g/ml), Salmonella typhimurium (MIC=12.5 ?g/ml), Proteus vulgaris (MIC>12.5 ?g/ml), Pseudomonas aeruginosa (MIC=12.5 ?g/ml), Escherichia coli O157 (MIC>12.5 ?g/ml).##Fungi: Trichosporon beigelii (MIC=12.5 ?g/ml), Candida albicans (MIC>25 ?g/ml), Saccharomyces cerevisiae (MIC>25 ?g/ml), Aspergillus flavus (MIC>50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC>50 ?g/ml), Fusarium moniliforme (MIC>50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16255716##PubMed ID is not available	Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published	"Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM."	"Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy."
DRAMP04080	AKKVSKRLEKLFSKIQNDK	19	Anal 5 (antimicrobial peptide HP (2-20)analogue)	P56029	Not found	Not found	Synthetic construct (amino acid substitution)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix (1 helices; 12 residues)	Not found	1P5L resolved by NMR.	Function: Has antibacterial and antifungal activiy. 	"Gram-positive bacteria: Bacillus subtilis (MIC=3.13 ?g/ml), Staphylococcus epidermidis (MIC=12.5 ?g/ml), Staphylococcus aureus (MIC>12.5 ?g/ml), Listeria monocytogenes (MIC>12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=6.25 ?g/ml), Salmonella typhimurium (MIC=12.5 ?g/ml), Proteus vulgaris (MIC>12.5 ?g/ml), Pseudomonas aeruginosa (MIC=12.5 ?g/ml), Escherichia coli O157 (MIC=6.25 ?g/ml).##Fungi: Trichosporon beigelii (MIC=12.5 ?g/ml), Candida albicans (MIC>25 ?g/ml), Saccharomyces cerevisiae (MIC>25 ?g/ml), Aspergillus flavus (MIC>50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC>50 ?g/ml), Fusarium moniliforme (MIC>50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16255716##PubMed ID is not available	Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published	"Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM."	"Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy."
DRAMP04081	AKKVFKRLEKLFSKIFNFK	19	Anal 6 (antimicrobial peptide HP (2-20)analogue)	P56029	Not found	Not found	Synthetic construct (amino acid substitution)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix 	Not found	None	Function: Has antibacterial and antifungal activiy. 	"Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=6.25 ?g/ml), Staphylococcus aureus (MIC=3.13 ?g/ml), Listeria monocytogenes (MIC=0.78 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ?g/ml), Salmonella typhimurium (MIC=0.39 ?g/ml), Proteus vulgaris (MIC=3.125 ?g/ml), Pseudomonas aeruginosa (MIC=6.25 ?g/ml), Escherichia coli O157 (MIC=6.25 ?g/ml).##Fungi: Trichosporon beigelii (MIC=3.13 ?g/ml), Candida albicans (MIC>25 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC=50-25 ?g/ml), Botrytis cinerea (MIC=12.5 ?g/ml), Fusarium moniliforme (MIC=12.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16255716##PubMed ID is not available	Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published	"Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM."	"Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy."
DRAMP04082	AKKVFKRLEKLFSKIYNYK	19	Anal 7 (antimicrobial peptide HP (2-20)analogue)	P56029	Not found	Not found	Synthetic construct (amino acid substitution)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix 	Not found	None	Function: Has antibacterial and antifungal activiy. 	"Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=3.13 ?g/ml), Staphylococcus aureus (MIC=3.13 ?g/ml), Listeria monocytogenes (MIC=0.78 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ?g/ml), Salmonella typhimurium (MIC=0.39 ?g/ml), Proteus vulgaris (MIC=6.25-3.13 ?g/ml), Pseudomonas aeruginosa (MIC=3.13 ?g/ml), Escherichia coli O157 (MIC=3.13 ?g/ml).##Fungi: Trichosporon beigelii (MIC=1.56 ?g/ml), Candida albicans (MIC=12.5 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC=50-25 ?g/ml), Botrytis cinerea (MIC=6.25 ?g/ml), Fusarium moniliforme (MIC=12.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16255716##PubMed ID is not available	Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published	"Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM."	"Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy."
DRAMP04083	GIGKFLKKAKKFGKAFVKILKK	22	D-amino-acid pexiganan (MSI-214)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	MSI-214 is a peptide identical in sequence to pexiganan but comprising all D-amino acids.	"Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=16 ?g/ml), Enterococcus faecium ATCC 51559 (vancomycin resistant) (MIC=4 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC=16 ?g/ml), Streptococcus bovis ATCC 49133 (MIC=4 ?g/ml), Micrococcus luteus ATCC 4698 (MIC=2-4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8-16 ?g/ml), Proteus mirabilis ATCC 29245 (MIC>256 ?g/ml), Serratia marcescens ATCC 8100 (MIC>256 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16-32 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10103181	Antimicrob Agents Chemother. 1999 Apr;43(4):782-788.	"Ge Y, MacDonald DL, Holroyd KJ, Thornsberry C, Wexler H, Zasloff M."	"In vitro antibacterial properties of pexiganan, an analog of magainin."
DRAMP04095	GFGSLFKFLAKKVAKTVAKQAAKQGAKYVANKHMQ	35	"Cupiennin-1D (spiders, Arthropods, animals)"	P83622	Belongs to the cupiennin family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane Function: with its amphipathic structure.
Tissue specificity: Expressed by the venom gland.
Toxic dose: LD50 is 6.4 pmol/mg on Drosophila."	"[Ref.11792701]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.31-0.63 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.31-0.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=0.31-0.63 ?M), Enterococcus faecalis ATCC 29212 (MIC=1.25-2.50 ?M)."	[Swiss_Prot Entry P83622]has hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11792701##10669026	J Biol Chem. 2002 Mar 29;277(13):11208-11216.##Toxicon. 2000 Mar;38(3):373-380.	"Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W.##Haeberli S, Kuhn-Nentwig L, Schaller J, Nentwig W."	"Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).##Characterisation of antibacterial activity of peptides isolated from the venom of the spider Cupiennius salei (Araneae: Ctenidae)."
DRAMP04096	EQEENVVKIQAFWKGYKQRKEYM	23	2IQ2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Displays antimicrobial activity against bacteria and yeast C. albicans.	Gram-negative bacterium: Escherichia coli (MIC=2.1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=32 ?M).##Yeast: Candida albicans (MIC=28 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23238369	Biochimie. 2013 Apr;95(4):875-880.	"McLean DT, Lundy FT, Timson DJ."	IQ-motif peptides as novel anti-microbial agents.
DRAMP04097	DNTDSVVKIQSWFRMATARKSYL	23	2IQ3	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Displays antimicrobial activity against bacteria and yeast C. albicans.	Gram-negative bacterium: Escherichia coli (MIC=1.2 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=26 ?M).##Yeast: Candida albicans (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23238369	Biochimie. 2013 Apr;95(4):875-880.	"McLean DT, Lundy FT, Timson DJ."	IQ-motif peptides as novel anti-microbial agents.
DRAMP04098	ANVGFVIQLQARLRGFLVRQKFA	23	3IQ1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Displays antimicrobial activity against bacteria and yeast C. albicans.	Gram-negative bacterium: Escherichia coli (MIC=1.7 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=1.7 ?M).##Yeast: Candida albicans (MIC>94 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23238369	Biochimie. 2013 Apr;95(4):875-880.	"McLean DT, Lundy FT, Timson DJ."	IQ-motif peptides as novel anti-microbial agents.
DRAMP04099	TWLPAVIKIQAHWRGYRQRKIYL	23	3IQ2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Displays antimicrobial activity against bacteria and yeast C. albicans.	Gram-negative bacterium: Escherichia coli (MIC=1.9 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=1.6 ?M).##Yeast: Candida albicans (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23238369	Biochimie. 2013 Apr;95(4):875-880.	"McLean DT, Lundy FT, Timson DJ."	IQ-motif peptides as novel anti-microbial agents.
DRAMP04100	ANLDAIIKIQAWARMWAARRQYL	23	3IQ3	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Displays antimicrobial activity against bacteria and yeast C. albicans.	Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=11 ?M).##Yeast: Candida albicans (MIC>89 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23238369	Biochimie. 2013 Apr;95(4):875-880.	"McLean DT, Lundy FT, Timson DJ."	IQ-motif peptides as novel anti-microbial agents.
DRAMP04101	KNVNSIVKIQAFFRARKAQDDYR	23	3IQ4	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Displays antimicrobial activity against bacteria and yeast C. albicans.	Gram-negative bacterium: Escherichia coli (MIC=3.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=4.6 ?M).##Yeast: Candida albicans (MIC=30 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23238369	Biochimie. 2013 Apr;95(4):875-880.	"McLean DT, Lundy FT, Timson DJ."	IQ-motif peptides as novel anti-microbial agents.
DRAMP04102	KWKSFIKKLTSKFLHLAKKF	20	CP-P	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity. Also has hemolytic activity against human erythrocytes.	[Ref.22518150]Gram-negative bacterium: Pseudomonas aeruginosa (MIC=12.5 ?g/ml).	[Ref.22518150]MHC=250 ?g/mL against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	Not found	Not found	Not found	Not found
DRAMP04103	KWKSFIKKLTSKFLHSAKKF	20	S16 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	"Gram-negative bacterium: Pseudomonas aeruginosa (MIC=3.125 ?g/ml).##Clinical isolates: Acinetobacter baumannii b-01 (MIC=3.125 ?g/mL), Acinetobacter baumannii b-02 (MIC=6.25 ?g/mL), Acinetobacter baumannii b-03 (MIC=6.25 ?g/mL), Acinetobacter baumannii b-04 (MIC=3.125 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04104	KFKSFIKKLTSKFLHSAKKF	20	F2 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity. Also has hemolytic activity against human erythrocytes.	[Ref.22518150]Gram-negative bacterium: Pseudomonas aeruginosa (MIC=12.5 ?g/ml).	[Ref.22518150]MHC=250 ?g/mL against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04105	KWNSFIKKLTSKFLHSAKKF	20	N3 (derivative of CP-P)	No entry found	Derived from the peptide CP-P	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=12.5 ¦Ìg/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04106	KWKSFKKKLTSKFLHSAKKF	20	K6 (derivative of CP-P)	No entry found	Derived from the peptide CP-P	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=12.5 ¦Ìg/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04107	KWKSFINKLTSKFLHSAKKF	20	N7 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=12.5 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04108	KWKSFIKKAKTSFLHSAKKF	20	A9 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=25 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04111	KWKSFIKKSTSKFLHSAKKF	20	S9 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=50 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04112	KWKSFIKKLLSKFLHSAKKF	20	L10 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity. Also has hemolytic activity against human erythrocytes.	[Ref.22518150]Gram-negative bacterium: Pseudomonas aeruginosa (MIC=12.5 ?g/ml).	[Ref.22518150]MHC<125 ?g/mL against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04113	KWKSFIKKLASKFLHSAKKF	20	A10 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity. Also has hemolytic activity against human erythrocytes.	[Ref.22518150]Gram-negative bacterium: Pseudomonas aeruginosa (MIC=12.5 ?g/ml).	[Ref.22518150]MHC=250 ?g/mL against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04114	KWKSFIKKLTDKFLHSAKKF	20	D11 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=25 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04115	KWKSFIKKLTKKFLHSAKKF	20	K11 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix (CD)	Not found	None	Function: Has antibacterial activity.	"Gram-positive bacteria: Staphylococcus aureus CMCC26003 (MIC=0.5 ?g/mL), Bacillus subtilis DB430 (MIC=2 ?g/mL), Bacillus pumilus CMCC63202 (MIC=0.5 ?g/mL), Soluble wall Micrococcus S1.634 (MIC=1 ?g/mL), Micrococcus luteus CMCC28001 (MIC=2 ?g/mL).##Gram-negative bacteria: E. coli ATCC8099 (MIC=0.5 ?g/mL), Klebsiella pneumoniae CMCC46117 (MIC=2 ?g/mL), Salmonella paratyphi BCMCC50094 (MIC=2 ?g/mL), Pseudomonas aeruginosa CMCC10104 (MIC=4 ?g/mL).##Clinical isolates: Acinetobacter baumannii b-01 (MIC=0.8 ?g/mL), Acinetobacter baumannii b-02 (MIC=3.125 ?g/mL), Acinetobacter baumannii b-03 (MIC=3.25 ?g/mL), Acinetobacter baumannii b-04 (MIC=1.6 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04117	KWKSFIKKLTSKALHSAKKF	20	A13 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=6.25 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04119	KWKSFIKKLTSKFLHSKKKF	20	K17 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=12.5 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04120	KWKSFIKKLTSKFLHSADKF	20	D18 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=25 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04121	KWKSFIKKLTSKFLHSANKF	20	N18 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=6.25 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04122	KWKSFIKKLTSKFLHSAKKN	20	N20 (derivative of CP-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Pseudomonas aeruginosa (MIC=6.25 ?g/ml)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150	Int J Microbiol. 2012;2012:764834.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L."	The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.
DRAMP04123	SGKLCCRRKK	10	D0-NH2(Derived from HBD-28 variant)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
Chemical modification: C-terminal amidation."	"[Ref.22518150] Gram-negative bacteria: Escherichia coli (MIC=12¡À0.17 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>100 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>100 ?M)."	[Ref.23860860] 2.2% hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150##23860860	Int J Microbiol. 2012;2012:764834. ##Biotechnol Bioeng.?2014 Jan;111(1):37-49. doi: 10.1002/bit.25003.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.##Saravanan R, Li X, Lim K, Mohanram H, Peng L, Mishra B, Basu A, Lee JM, Bhattacharjya S, Leong SS."	"The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.##Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility"
DRAMP04124	SGKLYYRRKK	10	D1-NH2 (Derived from D0)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
Chemical modification: C-terminal amidation."	"[Ref.22518150] Gram-negative bacteria: Escherichia coli (MIC=12¡À0.01 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>100 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>100 ?M)."	[Ref.23860860] 2.0% hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150##23860860	Int J Microbiol. 2012;2012:764834. ##Biotechnol Bioeng.?2014 Jan;111(1):37-49. doi: 10.1002/bit.25003.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.##Saravanan R, Li X, Lim K, Mohanram H, Peng L, Mishra B, Basu A, Lee JM, Bhattacharjya S, Leong SS."	"The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.##Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility"
DRAMP04125	SGKLWWRRKK	10	D2-NH2 (Derived from D0)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
Chemical modification: C-terminal amidation."	"[Ref.22518150]Gram-negative bacteria: Escherichia coli (MIC=6¡À0.012 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=12¡À0.01 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12¡À0.01 ?M)."	[Ref.23860860] 2.5% hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150##23860860	Int J Microbiol. 2012;2012:764834. ##Biotechnol Bioeng.?2014 Jan;111(1):37-49. doi: 10.1002/bit.25003.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.##Saravanan R, Li X, Lim K, Mohanram H, Peng L, Mishra B, Basu A, Lee JM, Bhattacharjya S, Leong SS."	"The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.##Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility"
DRAMP04126	SGKRWWRRKK	10	D3-NH2 (Derived from D0)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
Chemical modification: C-terminal amidation."	"[Ref.22518150] Gram-negative bacteria: Escherichia coli (MIC=6¡À0.012 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=6¡À0.078 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=25¡À0.01 ?M)."	[Ref.23860860] 5.0% hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150##23860860	Int J Microbiol. 2012;2012:764834. ##Biotechnol Bioeng.?2014 Jan;111(1):37-49. doi: 10.1002/bit.25003.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.##Saravanan R, Li X, Lim K, Mohanram H, Peng L, Mishra B, Basu A, Lee JM, Bhattacharjya S, Leong SS."	"The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.##Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility"
DRAMP04127	RGKRWWRRKK	10	D4-NH2(Derived from D0)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
Chemical modification: C-terminal amidation."	"[Ref.22518150] Gram-negative bacteria: Escherichia coli (MIC=3¡À0.012 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=6¡À0.04 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6¡À0.01 ?M)."	[Ref.23860860] 5.0% hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150##23860860	Int J Microbiol. 2012;2012:764834. ##Biotechnol Bioeng.?2014 Jan;111(1):37-49. doi: 10.1002/bit.25003.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.##Saravanan R, Li X, Lim K, Mohanram H, Peng L, Mishra B, Basu A, Lee JM, Bhattacharjya S, Leong SS."	"The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.##Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility"
DRAMP04128	RWKRWWRRKK	10	D5-NH2 (Derived from D0)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
Chemical modification: C-terminal amidation."	"[Ref.22518150] Gram-negative bacteria: Escherichia coli (MIC=3¡À0.012 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=3¡À0.012 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6¡À0.012 ?M)."	[Ref.23860860] 6.5% hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150##23860860	Int J Microbiol. 2012;2012:764834. ##Biotechnol Bioeng.?2014 Jan;111(1):37-49. doi: 10.1002/bit.25003.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.##Saravanan R, Li X, Lim K, Mohanram H, Peng L, Mishra B, Basu A, Lee JM, Bhattacharjya S, Leong SS."	"The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.##Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility"
DRAMP04129	RKKRWWRRKK	10	D6-NH2 (Derived from D0)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
Chemical modification: C-terminal amidation."	"[Ref.22518150] Gram-negative bacteria: Escherichia coli (MIC=3¡À0.07 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=3¡À0.012 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6¡À0.012 ?M)."	[Ref.23860860] 6.5% hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22518150##23860860	Int J Microbiol. 2012;2012:764834. ##Biotechnol Bioeng.?2014 Jan;111(1):37-49. doi: 10.1002/bit.25003.	"Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.##Saravanan R, Li X, Lim K, Mohanram H, Peng L, Mishra B, Basu A, Lee JM, Bhattacharjya S, Leong SS."	"The Design and Construction of K11: A Novel ¦Á-Helical Antimicrobial Peptide.##Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility"
DRAMP04136	LRRLWLRANRL	11	LRR-1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: E. coli ATCC 25922 (MIC=128 ?M), P. aeruginosa ATCC 27853 (MIC>128 ?M), S. typhimurium C7731 (MIC>128 ?M);##Gram-positive bacteria: S. epidermidis ATCC12228 (MIC>128 ?M), E. faecalis ATCC 29212 (MIC>128 ?M), S. aureus ATCC 29213 (MIC=128 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23430306	Amino Acids. 2013 Apr;44(4):1215-1224.	"Ma QQ, Lv YF, Gu Y, Dong N, Li DS, Shan AS."	Rational design of cationic antimicrobial peptides by the tandem of leucine-rich repeat.
DRAMP04137	LRRLWLRANRLLRRLWLRANRL	22	LRR-2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: E. coli ATCC 25922 (MIC=4 ?M), P. aeruginosa ATCC 27853 (MIC=4 ?M), S. typhimurium C7731 (MIC=2 ?M);##Gram-positive bacteria: S. epidermidis ATCC12228 (MIC=2 ?M), E. faecalis ATCC 29212 (MIC=2 ?M), S. aureus ATCC 29213 (MIC=2 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23430306	Amino Acids. 2013 Apr;44(4):1215-1224.	"Ma QQ, Lv YF, Gu Y, Dong N, Li DS, Shan AS."	Rational design of cationic antimicrobial peptides by the tandem of leucine-rich repeat.
DRAMP04138	APRKNVRW	8	L1 (first 8 N-terminal residues of bovine LF)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=62.36 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04139	APRKNVRF	8	L2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=129.66 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04140	APRKNVKW	8	L3	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=64.11 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04141	APRKNLKW	8	L4	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=31.61 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04142	APRKQLKW	8	L5	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=7.79 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04143	APRRQLKW	8	L6	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=15.17 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04144	APKKQLKW	8	L7	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=16.02 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04145	AFRKQLKW	8	L8	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=3.71 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04146	LFRKQLKW	8	L9	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli ATCC 25923 (MIC=1.78 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04147	WFRKQLKW	8	L10	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-negative bacteria: Escherichia coli ATCC 25923 (MIC=0.8 ?M), Klebsiella pneumoniae (MIC=3.35 ?M), Acinetobacter sp. (MIC=3.35 ?M), Psudomonas aruginosa (MIC=6.71 ?M).##Fungi: Candida albicans ATCC SC5314 (MIC=10.49 ?M), C. tropicalis ATCC 13803 (MIC=20.98 ?M), C. parapsilosis ATCC 22019 (MIC=5.24 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	23026014	Biochim Biophys Acta. 2013 Feb;1828(2):677-686.	"Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S."	"A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida."
DRAMP04159	RIKRFWPVVIRTVVAGYNLYRAIKK	25	LR2 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04160	RIKRFWPVVIRTVVAGYNLYRAIK	24	LR3 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=7.032 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=2.344 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=0.586 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04161	RIKRFWPVVIRTVVAGYNLYRAI	23	LR4 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=37.5 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=37.5 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=9.375 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04162	RIKRFWPVVIRTVVAGYNLYRA	22	LR5 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus ATCC25923 (MIC=75 ?g/ml);##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=4.688 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=4.688 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04163	RIKRFWPVVIRTVVAGYNLYR	21	LR6 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04164	RIKRFWPVVIRTVVAGYNLY	20	LR7 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04165	RIKRFWPVVIRTVVAGYNL	19	LR8 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04166	RIKRFWPVVIRTVVAGYN	18	LR9 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04167	RIKRFWPVVIRTVVAGY	17	LR10 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04168	RIKRFWPVVIRTVVAG	16	LR11 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04169	RIKRFWPVVIRTVV	14	LR13 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04170	RIKRFWPVVIRT	12	LR15 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04171	RIKRFWPVVIR	11	LR16 (homologue of Pc-CATH1)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.	"Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai."	Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
DRAMP04174	KWLKKWL	7	L2K3W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC=80 ?g/ml), S. aureus (MIC=80 ?g/ml), S. epidermis (MIC>80 ?g/ml), M. luteus (MIC>80 ?g/ml), S. aureus (MRSA) (MIC>80 ?g/ml).##Gram-negative bacteria: E. coli (MIC>80 ?g/ml), S. dysentariae (MIC>80 ?g/ml), S. typhimorium (MIC>80 ?g/ml), K. pneumoniae (MIC>80 ?g/ml), P. aeruginosa (MIC>80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04175	KWLLKWL	7	L3K2W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC=20 ?g/ml), S. aureus (MIC=20 ?g/ml), S. epidermis (MIC=80 ?g/ml), M. luteus (MIC=80 ?g/ml), S. aureus (MRSA) (MIC>80 ?g/ml).##Gram-negative bacteria: E. coli (MIC=40 ?g/ml), S. dysentariae (MIC>80 ?g/ml), S. typhimorium (MIC>80 ?g/ml), K. pneumoniae (MIC=80 ?g/ml), P. aeruginosa (MIC=80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04176	KKWLKKWLK	9	L2K5W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC=80 ?g/ml), S. aureus (MIC=40 ?g/ml), S. epidermis (MIC>80 ?g/ml), M. luteus (MIC>80 ?g/ml), S. aureus (MRSA) (MIC>80 ?g/ml).##Gram-negative bacteria: E. coli (MIC=40 ?g/ml), S. dysentariae (MIC>80 ?g/ml), S. typhimorium (MIC>80 ?g/ml), K. pneumoniae (MIC>80 ?g/ml), P. aeruginosa (MIC=80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04177	LKWLKKWLK	9	L3K4W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC=40 ?g/ml), S. aureus (MIC=10 ?g/ml), S. epidermis (MIC=40 ?g/ml), M. luteus (MIC=80 ?g/ml), S. aureus (MRSA) (MIC>80 ?g/ml).##Gram-negative bacteria: E. coli (MIC=40 ?g/ml), S. dysentariae (MIC>80 ?g/ml), S. typhimorium (MIC>80 ?g/ml), K. pneumoniae (MIC>80 ?g/ml), P. aeruginosa (MIC=80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04178	LKWLLKWLK	9	L4K3W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC=5 ?g/ml), S. aureus (MIC=2.5 ?g/ml), S. epidermis (MIC=5 ?g/ml), M. luteus (MIC=10 ?g/ml), S. aureus (MRSA) (MIC=20 ?g/ml).##Gram-negative bacteria: E. coli (MIC=5 ?g/ml), S. dysentariae (MIC=40 ?g/ml), S. typhimorium (MIC=20 ?g/ml), K. pneumoniae (MIC=20 ?g/ml), P. aeruginosa (MIC=40 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04179	LKWLLKWLL	9	L5K2W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC<1.3 ?g/ml), S. aureus (MIC<1.3 ?g/ml), S. epidermis (MIC<1.3 ?g/ml), M. luteus (MIC=2.5 ?g/ml), S. aureus (MRSA) (MIC=2.5 ?g/ml).##Gram-negative bacteria: E. coli (MIC=5 ?g/ml), S. dysentariae (MIC=2.5 ?g/ml), S. typhimorium (MIC=10 ?g/ml), K. pneumoniae (MIC=5 ?g/ml), P. aeruginosa (MIC=10 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04180	LKKWLKKWLKK	11	L3K6W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC=20 ?g/ml), S. aureus (MIC=10 ?g/ml), S. epidermis (MIC=40 ?g/ml), M. luteus (MIC=40 ?g/ml), S. aureus (MRSA) (MIC>80 ?g/ml).##Gram-negative bacteria: E. coli (MIC=20 ?g/ml), S. dysentariae (MIC=80 ?g/ml), S. typhimorium (MIC>80 ?g/ml), K. pneumoniae (MIC>80 ?g/ml), P. aeruginosa (MIC=40 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04181	LLKWLKKWLKK	11	L4K5W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC=2.5 ?g/ml), S. aureus (MIC=2.5 ?g/ml), S. epidermis (MIC=2.5 ?g/ml), M. luteus (MIC=2.5 ?g/ml), S. aureus (MRSA) (MIC=40 ?g/ml).##Gram-negative bacteria: E. coli (MIC=40 ?g/ml), S. dysentariae (MIC=80 ?g/ml), S. typhimorium (MIC=40 ?g/ml), K. pneumoniae (MIC=40 ?g/ml), P. aeruginosa (MIC=20 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04182	LLKWLLKWLKK	11	L5K4W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC<1.3 ?g/ml), S. aureus (MIC<1.3 ?g/ml), S. epidermis (MIC<1.3 ?g/ml), M. luteus (MIC<1.3 ?g/ml), S. aureus (MRSA) (MIC=5 ?g/ml).##Gram-negative bacteria: E. coli (MIC=10 ?g/ml), S. dysentariae (MIC=10 ?g/ml), S. typhimorium (MIC=20 ?g/ml), K. pneumoniae (MIC=20 ?g/ml), P. aeruginosa (MIC=10 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04183	LLKWLLKWLLK	11	L6K3W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC<1.3 ?g/ml), S. aureus (MIC=2.5 ?g/ml), S. epidermis (MIC<1.3 ?g/ml), M. luteus (MIC=2.5 ?g/ml), S. aureus (MRSA) (MIC=5 ?g/ml).##Gram-negative bacteria: E. coli (MIC>80 ?g/ml), S. dysentariae (MIC>80 ?g/ml), S. typhimorium (MIC>80 ?g/ml), K. pneumoniae (MIC>80 ?g/ml), P. aeruginosa (MIC>80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04185	GLLPLLSLLGKLL	13	DFTamP1-p	No entry found	Not found	Not found	Synthetic construct (Ab Initio Design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antimicrobial activities.	"Gram-positive bacteria: S. aureus USA300 (MIC=1.56 ?M), B. subtilis (MIC=3.12 ?M).##Gram-negative bacteria: E. coli K12 (MIC=25 ?M), P. aeruginosa (MIC>100 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22803960	J Am Chem Soc. 2012 Aug 1;134(30):12426-9.	"Mishra B, Wang G."	"Ab Initio Design of Potent Anti-MRSA Peptides Based on Database
Filtering Technology."
DRAMP04186	WLKKLLKKLLK	11	L5K5W1 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=2 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=4 ?g/mL), MRSA-TK784 (MIC=8 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=2 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=2 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=2 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04187	KWLKKLLKKLL	11	L5K5W2 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=2 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=4 ?g/mL), MRSA-TK784 (MIC=8 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=1 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=2 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=2 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04188	LKWLKKLLKKL	11	L5K5W3 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=4 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=4 ?g/mL), MRSA-TK784 (MIC=8 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=2 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=4 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=2 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04189	LLKWLKKLLKK	11	L5K5W4 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=2 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=4 ?g/mL), MRSA-TK784 (MIC=16 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=2 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=4 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=4 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04190	KLLKWLKKLLK	11	L5K5W5 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=2 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=2 ?g/mL), MRSA-TK784 (MIC=8 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=2 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=2 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=2 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04192	LKKLLKWLKKL	11	L5K5W7 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=2 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=4 ?g/mL), MRSA-TK784 (MIC=16 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=2 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=4 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=2 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04193	LLKKLLKWLKK	11	L5K5W8 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=4 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=4 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=4 ?g/mL), MRSA-TK784 (MIC=16 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=4 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=4 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=4 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04194	KLLKKLLKWLK	11	L5K5W9 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=2 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=4 ?g/mL), MRSA-TK784 (MIC=8 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=2 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=2 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=2 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04195	KKLLKKLLKWL	11	L5K5W10 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=1 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=1 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=1 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=2 ?g/mL), MRSA-TK784 (MIC=4 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=1 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=1 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=2 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04196	LKKLLKKLLKW	11	L5K5W11 (L5K5Wn model peptide)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 ?g/mL), Staphylococcus aureus ATCC 6538p (MIC=2 ?g/mL), Staphylococcus epidermis ATCC 12228 (MIC=2 ?g/mL), Micrococcus luteus ATCC 10240 (MIC=4 ?g/mL), MRSA-TK784 (MIC=16 ?g/mL).##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4 ?g/mL), Shigella dysenteriae ATCC 9752 (MIC=2 ?g/mL), Salmonella typhimurium ATCC 14028 (MIC=4 ?g/mL), Klebsiella pneumoniae ATCC 10031 (MIC=4 ?g/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23344198	Molecules. 2013 Jan 11;18(1):859-876.	"Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS."	Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.
DRAMP04237	GLFDIVKKLVSDF	13	Antibacterial peptide A4	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix (1 helices; 8 residues)	Not found	1VM4 resolved by NMR.	Function: Has antibacterial activity against the Gram-negative bacterium E. coli.	Gram-negative bacterium: Escherichia coli (MIC=100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15572363	J Biol Chem. 2005 Feb 18;280(7):5803-5811.	"Wang G, Li Y, Li X."	Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor.
DRAMP04240	KLKLLLLL	8	Synthetic 1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive and Gram-negative bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), S. aureus (MRSA) (MIC>35 ?g/ml).##Gram-negative bacterium: Escherichia coli (MIC=20 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8093007	Biochem J. 1994 Sep 1;302 ( Pt 2):535-538.	"Alvarez-Bravo J, Kurata S, Natori S."	Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus.
DRAMP04241	KLKLLLLLKLK	11	Synthetic 2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive and Gram-negative bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), S. aureus (MRSA) (MIC=30 ?g/ml).##Gram-negative bacterium: Escherichia coli (MIC=20 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8093007	Biochem J. 1994 Sep 1;302 ( Pt 2):535-538.	"Alvarez-Bravo J, Kurata S, Natori S."	Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus.
DRAMP04242	RLKLLLLLRLK	11	Synthetic 3	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive and Gram-negative bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=1 ?g/ml), S. aureus (MRSA) (MIC=30 ?g/ml).##Gram-negative bacterium: Escherichia coli (MIC=20 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8093007	Biochem J. 1994 Sep 1;302 ( Pt 2):535-538.	"Alvarez-Bravo J, Kurata S, Natori S."	Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus.
DRAMP04243	RLKLLLLRLK	10	Synthetic 4	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive and Gram-negative bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), S. aureus (MRSA) (MIC>35 ?g/ml).##Gram-negative bacterium: Escherichia coli (MIC=20 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8093007	Biochem J. 1994 Sep 1;302 ( Pt 2):535-538.	"Alvarez-Bravo J, Kurata S, Natori S."	Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus.
DRAMP04244	RLKLLLRLK	9	Synthetic 5	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activity against the Gram-positive and Gram-negative bacteria.	"Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), S. aureus (MRSA) (MIC>35 ?g/ml).##Gram-negative bacterium: Escherichia coli (MIC=20 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8093007	Biochem J. 1994 Sep 1;302 ( Pt 2):535-538.	"Alvarez-Bravo J, Kurata S, Natori S."	Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus.
DRAMP04264	KWKSFIKKLTSAAKKVVTTAKPLISS	26	CP26	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=1 ¦Ìg/ml), Salmonella typhimurium (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=1 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04265	KWKSFIKKLTTAVKKVLTTGLPALIS	26	CP29	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=6 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=2 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04359	INWKKIFQKVKNLV	14	PDD-A-1 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli. PDD-A also shows hemolytic activity.	[Ref.18375018]Gram-negative bacterium: Escherichia coli (MIC=8 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=45 ?M).	[Ref.18375018]IC50 = 100 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04360	INWKKIFEKVKDLV	14	PDD-A-2 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=9 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04361	IDWKKIFEKVKNLV	14	PDD-A-3 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=8.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04362	IDWKKIFEKVKDLV	14	PDD-A-4 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=47.5 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=17.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04363	INWSKIFEKVKNLV	14	PDD-A-5 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=17 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04364	INWSSIFEKVKNLV	14	PDD-A-6 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=35 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=40 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04365	INWSSIFESVKNLV	14	PDD-A-7 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=87.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04367	INWKKIFEKVSNLV	14	PDD-A-9 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=22.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04368	INWKKIFESVKNLV	14	PDD-A-10 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=10 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04369	INWKSIFEKVKNLV	14	PDD-A-11 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=15 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=15 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04370	NIWKKIFEKVKNLV	14	PDD-A-12 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=20 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04371	INWLKLGKKILGAI	14	PDD-B-1 (PDD-B analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=67.5 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04372	INWLRLGRRILGAL	14	PDD-B-2 (PDD-B analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC>100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=17.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04373	INFLKLGKKILGAL	14	PDD-B-3 (PDD-B analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC>100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=22.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04374	INWKKLGKKILGAL	14	PDD-B-4 (PDD-B analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=43 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=15.5 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04376	INWLKLGKKIISAL	14	MP-1 (MP analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=15 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04377	INWLKLGKKLLSAL	14	MP-2 (MP analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=25 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04378	INWLKLGKKMMSAI	14	MP-5 (MP analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=70 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=35 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04379	SNWLKLGKKMMSAL	14	MP-6 (MP analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=40 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04380	INWKKIASIGKEVLKAI	17	PMM-1 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=5.5 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=27.2 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04381	NWKKIASIGKEVLKAL	16	PMM-2 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=21 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=46 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04382	WKKIASIGKEVLKAL	15	PMM-3 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=62 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=125 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04383	KKIASIGKEVLKAL	14	PMM-4 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC>100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=75 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04385	INWKKIASIGKEVLKA	16	PMM-6 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=75 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=70 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04386	INWKKIASIGKEVLK	15	PMM-7 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04387	INWKKIASIGKEVL	14	PMM-8 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04389	IWNKIAKSIGKVLEKAL	17	PMM-10 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=15 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=35 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04390	INWKKGKEVLKAL	13	PMM-11 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC>100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04391	NIWKKIASIAKEVLKAL	17	PMM-12 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=6.25 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=10 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04392	KNWKKIASIGKEVLKAL	17	PMM-13 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=60 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04393	SNWKKIASIGKEVLKAL	17	PMM-14 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=30 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04542	IDWKKLLDAAKQIL	6	"Polybia-MP-I (insects, vertebrates, animals)"	No entry found	Not found	Not found	Polybia paulista (Neotropical social wasp)	"Antimicrobial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli (MIC=5 ?M), Pseudomonas aeruginosa (MIC=5 ?M).##Gram-positive bacterium: Staphylococcus aureus (MIC=9 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19463874	Peptides. 2009 Aug;30(8):1387-1395.	"de Souza BM, da Silva AV, Resende VM, Arcuri HA, Dos Santos Cabrera MP, Ruggiero Neto J, Palma MS."	Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista.
DRAMP04543	IDWLKLGKMVIDAL	14	"Polybia-MP-II (insects, vertebrates, animals)"	No entry found	Not found	Not found	Polybia paulista (Neotropical social wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytotoxic"	Not found	Alpha helix	It forms amphipathic alpha-helical conformations under membrane-mimetic conditions.	None	"Function: Both peptides (Polybia-MP-II and -III) are polyfunctional, causing pronounced cell lysis of rat mast cells and erythrocytes, in addition to having antimicrobial activity against both Gram-positive and Gram-negative bacteria.
PTM: C-terminal amidation."	"Gram-negative bacteria: Escherichia coli (MIC=5 ?M), Pseudomonas aeruginosa (MIC=38 ?M).##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?M), Bacillus cereus (MIC=5 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19463874	Peptides. 2009 Aug;30(8):1387-1395.	"de Souza BM, da Silva AV, Resende VM, Arcuri HA, Dos Santos Cabrera MP, Ruggiero Neto J, Palma MS."	Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista.
DRAMP04544	IDWLKLGKMVMDVL	14	"Polybia-MP-III (insects, vertebrates, animals)"	No entry found	Not found	Not found	Polybia paulista (Neotropical social wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytotoxic"	Not found	Alpha helix	It forms amphipathic alpha-helical conformations under membrane-mimetic conditions.	None	"Function: Both peptides (Polybia-MP-II and -III) are polyfunctional, causing pronounced cell lysis of rat mast cells and erythrocytes, in addition to having antimicrobial activity against both Gram-positive and Gram-negative bacteria.
PTM: C-terminal amidation."	"Gram-negative bacteria: Escherichia coli (MIC=38 ?M), Pseudomonas aeruginosa (MIC=310 ?M).##Gram-positive bacteria: Staphylococcus aureus (MIC=19 ?M), Bacillus cereus (MIC=38 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19463874	Peptides. 2009 Aug;30(8):1387-1395.	"de Souza BM, da Silva AV, Resende VM, Arcuri HA, Dos Santos Cabrera MP, Ruggiero Neto J, Palma MS."	Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista.
DRAMP04545	SFPFFPPGICKRLKRC	16	"Limnonectin-1Fa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Limnonectes fujianensis (Fujian large-headed frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Possesses relatively potent growth inhibitory activity against the Gram-negative bacterium E. coli. Ineffective against the Gram-positive bacterium S. aureus and the potentially pathogenic yeast C. albicans at concentrations up to 160 ?M.	Gram-negative bacterium: Escherichia coli (MIC=35 ?M)	[Ref.21396976] It exhibits no hemolytic activity at a concentration of up to 160 ¦ÌM.	Cyclic	Free	Cyclization(Cys10 and Cys16).	Disulfide bond between Cys10 and Cys16.	L	No cytotoxicity information found	Not found	21396976	Biochimie. 2011 Jun;93(6):981-987.	"Wu Y, Wang L, Zhou M, Ma C, Chen X, Bai B, Chen T, Shaw C."	Limnonectins: A new class of antimicrobial peptides from the skin secretion of the Fujian large-headed frog (Limnonectes fujianensis).
DRAMP04546	SFHVFPPWMCKSLKKC	16	"Limnonectin-1Fb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Limnonectes fujianensis (Fujian large-headed frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Possesses relatively potent growth inhibitory activity against the Gram-negative bacterium E. coli. Ineffective against the Gram-positive bacterium S. aureus and the potentially pathogenic yeast C. albicans at concentrations up to 160 ?M.	Gram-negative bacterium: Escherichia coli (MIC=70 ?M)	[Ref.21396976] It exhibits no hemolytic activity at a concentration of up to 160 ¦ÌM.	Cyclic	Free	Cyclization(Cys10 and Cys16).	Disulfide bond between Cys10 and Cys16.	L	No cytotoxicity information found	Not found	21396976	Biochimie. 2011 Jun;93(6):981-987.	"Wu Y, Wang L, Zhou M, Ma C, Chen X, Bai B, Chen T, Shaw C."	Limnonectins: A new class of antimicrobial peptides from the skin secretion of the Fujian large-headed frog (Limnonectes fujianensis).
DRAMP04553	GVIKSVLKGVAKTVALGML	19	H. erythraea B2RP	No entry found	Not found	Not found	Hylarana erythraea	"Antimicrobial, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli (MIC=12.5 microM);##Gram-poaitive bacteria: Staphylococcus aureus (MIC=12.5 microM), multidrug-resistant clinical isolates of Acetinobacter baumannii (MIC in the range 6-12.5 microM).##Yeast: Candida albicans (MIC=50 microM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20015460	Peptides. 2010 Apr;31(4):548-554.	"Al-Ghaferi N, Kolodziejek J, Nowotny N, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD, Conlon JM."	Antimicrobial peptides from the skin secretions of the South-East Asian frog Hylarana erythraea (Ranidae).
DRAMP04640	GMASKAGSVLGKLAKVAIGAL	21	PGLa-AN2	No entry found	Not found	Not found	Xenopus andrei	"Antimicrobial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: E. coli (MIC=25 ?M);##Gram-positive bacterium: S. aureus (MIC=100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21498136	Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun;6(2):206-212.	"Mechkarska M, Eman A, Coquet L, J¨¦r?me L, Jouenne T, Vaudry H, King JD, Takada K, Conlon JM."	Genome duplications within the Xenopodinae do not increase the multiplicity of antimicrobial peptides in Silurana paratropicalis and Xenopus andrei skin secretions.
DRAMP04665	KPFKKLEKVGRNIRDGIIKAGPAVAVIGQATSIARPTGK	39	Px-cec1	No entry found	Not found	Not found	Plutella xylostella (Diamondback moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix (CD)	A circular dichroism (CD) analysis revealed that the recombinant Px-cec1 mainly contained ¦Á-helixes.	None	"Function: Recombinant Px-cec1 exhibites a broad spectrum of anti-microbial properties against fungi, Gram-positive and Gram-negative bacteria, but it does not exhibit hemolytic activity against human erythrocytes."	"[Ref.22921836]Gram-positive bacterium: S. aureus (MIC=2 ?M);##Gram-negative bacteria: E. coli (MIC=0.1 ?M), Pseudomonas fluorescent (MIC=1.1 ?M), Salmonella choleraesuis (MIC=2.1 ?M);##Fungi: Aureobasidium pullulans (MIC=4.0 ?M), Aspergillus flavus (MIC=14.5 ?M), Aspergillus fumigatus (MIC=16.0 ?M), Aspergillus niger (MIC=14.6 ?M), Fusarium oxysporum (MIC=8.0 ?M)."	[Ref.22921836]Non-hemolytic activity against human erythrocytes.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22921836	Protein Expr Purif. 2012 Oct;85(2):230-238. 	"Jin F, Sun Q, Xu X, Li L, Gao G, Xu Y, Yu X, Ren S."	"cDNA cloning and characterization of the antibacterial peptide cecropin 1 from the diamondback moth, Plutella xylostella L."
DRAMP04670	KNIGNSVSCLRNKGVCMPGKCAPKMKQIGTCGMPQVKCCKRK	42	PBD1-42	No entry found	Not found	Not found	Boletus edulis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: The recombinant pBD142 exhibited antimicrobial activity against both Gram-positive Staphylococcus aureus and Gram-negative E. coli including the multi-resistant E. coli. Shows hemolytic activity and high thermal stability. 	[Ref.23220638]Gram-negative bacterium: Escherichia coli (MIC=100 ?g/mL);##Gram-positive bacterium: Staphylococcus aureus (MIC=80 ?g/mL).	"[Ref.23220638]5% hemolytic activity at 10 ¦Ìg/mL, 10% hemolytic activity at 20 ¦Ìg/mL, 10% hemolytic activity at 100 ¦Ìg/mL against porcine fresh blood"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23220638	Protein Expr Purif. 2013 Mar;88(1):47-53.	"Li CL, Xu TT, Chen RB, Huang XX, Zhao YC, Bao YY, Zhao WD, Zheng ZY."	"Cloning, expression and characterization of antimicrobial porcine b defensin 1 in Escherichia coli."
DRAMP04671	TDHQMAQSACIGVSQDNAYASAIPRDCHGG	30	Myticusin-1	No entry found	Not found	Not found	Mytilus coruscus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Myticusin-1 exhibites stronger anti-microbial properties against Gram-positive bacteria more than Gram-negative bacteria and fungus.	"Gram-negative bacteria: Escherichia coli (MIC=6.7-12.5 ?M), Vibrio Parahaemolyticus (MIC>25.0 ?M), Pseudomonas aeruginosa (MIC>25.0 ?M), Vibrio.harveyi (MIC=12.5-25.0 ?M).##Gram-positive bacteria: Bacillus subtilis (MIC=1.2-2.5 ?M), Staphylococcus aureus (MIC=2.5-5.0 ?M), Sarcina luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=2.5-5.0 ?M).##Fungi: Candida albicans (MIC=6.7-12.5 ?M), Monilia albican (MIC=12.5-25.0 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23247103	Fish Shellfish Immunol. 2013 Feb;34(2):610-616.	"Liao Z, Wang XC, Liu HH, Fan MH, Sun JJ, Shen W."	Molecular characterization of a novel antimicrobial peptide from Mytilus coruscus.
DRAMP04676	MFTLKKPLLLLFFLGTISLSLCQEERDADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC	75	Brevinin-2HS2A	E7EKE0	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hainanensis (Odor frog) (Rana hainanensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Has antimicrobial activity against some Gram-positive bacteria and fungi but has no activity against a range of Gram- negative bacteria except P.faecalis. Has extremely low hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the skin glands."	"[Ref.22450466]Gram-positive bacteria: S.aureus ATCC 25923 (MIC=19 ?M), B.licheniformis X39 (MIC=37.5 ?M) and R.rhodochrous X15 (MIC=9.5 ?M);##Gram-negative bacterium: P. faecalis X29 (MIC=9.5 ?M);##Fungi: C. albicans ATCC 2002 (MIC=19 ?M), slime mold 090223 (MIC=37.5 ?M)."	[Ref.22450466]LC50=300 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22450466	Peptides. 2012 Jun;35(2):285-290.	"Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J."	"Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis."
DRAMP04677	MFTMKKPLLLIVLLGIISLSLCEQERAADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC	75	Brevinin-2HS2B	E7EKE1	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hainanensis (Odor frog) (Rana hainanensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Has antimicrobial activity against some Gram-positive bacteria and fungi but has no activity against a range of Gram- negative bacteria except P. faecalis. Has low hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the skin glands."	"[Ref.22450466]Gram-positive bacteria: S.aureus ATCC 25923 (MIC=19 ?M), B. licheniformis X39 (MIC=37.5 ?M) and R. rhodochrous X15 (MIC=9.5 ?M);##Gram-negative bacterium: P. faecalis X29 (MIC=9.5 ?M);##Fungi: C. albicans ATCC 2002 (MIC=19 ?M), slime mold 090223 (MIC=37.5 ?M)."	[Ref.22450466]LC50=300 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22450466	Peptides. 2012 Jun;35(2):285-290.	"Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J."	"Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis."
DRAMP00052	NRWWQGVVPTVSYECRMNSWQHVFTCC	27	Mutacin-2 (Mutacin II mutacin H-29B; Bacteriocin)	"O54329, P84110"	Belongs to the type A lantibiotic family (Class I bacteriocin)	mutA	Streptococcus mutans (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Rich	Not found	None	"Function: Mutacin-2 inhibits other mutans streptococci as well as many gram-positive exogenous pathogens. Transiently and partially depolarizes the transmembrane electrical potential and pH gradient of susceptible cells, inhibits the uptake of amino acids and depletes the intracellular ATP pool.
Biophysicochemical properties: pH dependence (Stable from pH 4.0 to 10.0); Temperature dependence (Thermostable).
PTM: There are one didehydrobutyrine (T25), two lanthionines (S12-C26; S19-C27) and one Beta-methyllanthionine (T10-C15)."	"Gram-positive bacteria: Micrococcus luteus, Staphylococcus aureus, Peptostreptococcus micros, Pediococcus acidilactici, Clostridium sporogenes, Corynebacterium diphtheriae, Actinomyces viscosus, Gardnerella vaginalis, Propionibacterium acnes, Listeria monocytogenes, Mycobacterium smegmatis.##Gram-negative bacteria: Campylobacter jejuni, Helicobacter pylori, Neisseria gonorrhoeae."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10821848##8592997##16626493##8021218	J Biol Chem. 2000 May 26;275(21):15845-15850.##Antimicrob Agents Chemother. 1995 Dec;39(12):2656-2660.##BMC Microbiol. 2006 Apr 20;6:36.##J Bacteriol. 1994 Jul;176(14):4316-4320.	"Krull RE, Chen P, Novak J, Kirk M, Barnes S, Baker J, Krishna NR, Caufield PW.##Chikindas ML, Nov?k J, Driessen AJ, Konings WN, Schilling KM, Caufield PW.##Nicolas G, Morency H, LaPointe G, Lavoie MC.##Nov?k J, Caufield PW, Miller EJ."	"Biochemical structural analysis of the lantibiotic mutacin II.##Mutacin II, a bactericidal antibiotic from Streptococcus mutans.##Mutacin H-29B is identical to mutacin II (J-T8).##Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans."
DRAMP00055	ITSVSWCTPGCTSEGGGSGCSHCC	24	Bacteriocin 97518	No entry found	Belongs to the type A lantibiotic family (Class I bacteriocin)	Not found	Planomonospora sp. (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Rich 	Not found	None	"Function: It inhibits cell wall synthesis of Gram-positive bacteria, including Staphylococcus aureus (MRSA)."	"Gram-negative bacteria: Escherichia coli, Moraxella catarrhalis.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17469849	Biochemistry. 2007 May 22;46(20):5884-5895.	"Castiglione F, Cavaletti L, Losi D, Lazzarini A, Carrano L, Feroggio M, Ciciliato I, Corti E, Candiani G, Marinelli F, Selva E."	A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp.
DRAMP00064	MSKRDCNLMKACCAGQAVTYAIHSLLNRLGGDSSDPAGCNDIVRKYCK	48	Enterocin 96 (Bacteriocin)	Q82YI9	Belongs to the class II bacteriocin	Not found	Enterococcus faecalis (strain ATCC 700802 / V583) (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	Search in protein databases revealed that enterocin 96 was identical to the C-terminal part of a putative uncharacterized protein from Enterococcus faecalis V583 (accession number EF_B0056) identified after complete genome sequencing of this strain. The amino acid sequence of this protein contains an N-terminal extension of 26 amino acids with two C-terminal 1 glycyl residues. The likely presence of such an extension for enterocin 96 was investigated by sequencing its structural gene.	"Gram-positive bacteria: Enterococcus faecalis, E. faecium WHE, E. hirae, E. pseudoavium, E. sulfureus, E. saccharolyticus, E. columbae, Lactobacillus plantarum, L. acidophilus, Lactobacillus sakeii subsp. sakei, L. paracasei subsp. paracasei, Lactococcus lactis, Lactococcus lactis subsp. cremoris, Leuconostoc mesenteroides, Bacillus subtilis, Bacillus cereus, Listeria innocua, Listeria monocytogenes, Staphylococcus xylosus, Staphylococcus aureus;##Gram-negative bacteria: Salmonella enterica serovar Typhimurium, S. enterica serovar Infantis, Klebsiella pneumoniae, Serratia liquefaciens, Proteus vulgaris, Enterobacter cloacae, Escherichia coli."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12663927	Science. 2003 Mar 28;299(5615):2071-2074.	"Paulsen IT, Banerjei L, Myers GS, Nelson KE, Seshadri R, Read TD, Fouts DE, Eisen JA, Gill SR, Heidelberg JF, Tettelin H, Dodson RJ, Umayam L, Brinkac L, Beanan M, Daugherty S, DeBoy RT, Durkin S, Kolonay J, Madupu R, Nelson W, Vamathevan J, Tran B, Upton J, Hansen T, Shetty J, Khouri H, Utterback T, Radune D, Ketchum KA, Dougherty BA, Fraser CM."	Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.
DRAMP00070	ACQCPDAISGWTHTDYQCHGLENKMYRHVYAICMNGTQVYCRTEWGSSC	49	Laterosporulin (Bacteriocin)	No entry found	Belongs to the class II bacteriocin	Not found	Brevibacillus sp. Strain GI-9 (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"The bacteriocin was produced after 12 hours in the lag phase and the use of Diaion HP-20 hydrophobic resin increased yield. Partial sequence was determined and the entire sequence was deduced. This peptide is thermal stable, pH tolerant, and resistant to proteases. Reducing agent DTT had no effect on peptide activity or migration on gel."	"Gram-positive bacteria: Bacillus subtilis, Staphylococcus aureus, Listeria monocytogenesa;##Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22403615	PLoS One. 2012;7(3):e31498. 	"Singh PK, Chittpurna, Ashish, Sharma V, Patil PB, Korpole S."	"Identification, Purification and Characterization of Laterosporulin, a Novel Bacteriocin Produced by Brevibacillus sp. Strain GI-9."
DRAMP00085	TSYGNGVHCNKSKCWIDVSELETYKAGTVSNPKDILWSLKE	41	Bacteriocin	P86291	Belongs to the class IIa bacteriocin	Not found	Lactococcus sp	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has bacteriocin active.	"Gram-positive bacteria: Streptococcus aureus, Bacillus thuringiensis;##Gram-negative bacteria: Salmonella typhi, Klebsiella sp., Escherichia coli KL16 and Escherichia coli Gj137."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (APR-2009) to UniProtKB	Ingale A.G.	Molecular characterisation of bacteriocin from microflora associated with radish and ginger.
DRAMP00169	MAKEFGIPAAVAGTVINVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW	70	Enterocin AS-48 (AS-48; Bacteriocin)	Q47765	Belongs to the class IIc bacteriocin	as-48	Enterococcus faecalis S-48 (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix (6 helices; 54 residues)	The NMR structure of AS-48 at pH 3 showed that AS-48 is a monomer consisting of a bundle of five helices arranged with the topology of the saposin fold.	"1E68 resolved by NMR.##1O82,1O83,1O84 resolved by X-ray."	"Function: The bacteriocin AS-48 is a membrane-interacting peptide, which displays a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. The antimicrobial effect of AS-48 is due to its ability to form pores in the membranes of sensitive bacteria, leading to the efflux of small molecules and the depletion of the membrane electrical potential and ultimately leading to cell death."	"Gram-positive bacteria: Bacillus subtilus, Bacillus cereus, Bacillus circulans, Bacillus megaterium, Corynebacterium glutamicum, Corynebacterium bovis, Mycobacterium phlei, Nocardia corrallina, Micrococcus luteus, Micrococcus lysodeikticus, Staphylococcus aureus, Streptococcus faecalis, Streptococcus faecium;##Gram-negative bacteria: Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Proteus inconstans, Salmonella typhimurium, Shigella sonnei, Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas reptilivora."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	No specific N-terminal	No specific C-terminal	"Hydrogen bonds between Ala-2 and Ile-7, Val-18 and Gly-23,  Thr-33 and Gly-36, the backbone carbonyl oxygen of Phe-5 and the side-chain hydroxylic proton of Ser-50"	L	No cytotoxicity information found	Cell membrane	2501837##14623193##11005847	Res Microbiol. 1989 Jan;140(1):57-68.##J Mol Biol. 2003 Nov 28;334(3):541-549.##Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11221-6.	"G?lvez A, Maqueda M, Mart?nez-Bueno M, Valdivia E.##S?nchez-Barrena MJ, Mart?nez-Ripoll M, G?lvez A, Valdivia E, Maqueda M, Cruz V, Albert A.##Gonz?lez C, Langdon GM, Bruix M, G?lvez A, Valdivia E, Maqueda M, Rico M."	"Bactericidal and bacteriolytic action of peptide antibiotic AS-48 against gram-positive and Gram-negative bacteria and other organisms.##Structure of bacteriocin AS-48: from soluble state to membrane bound state.##Bacteriocin AS-48, a microbial cyclic polypeptide structurally and functionally related to mammalian NK-lysin."
DRAMP18338	STNCFCYICCSCSS	14	Thiocillin GE37468 (Bacteriocin)	P0C8P9	Belongs to the class I bacteriocin	getA	Streptomyces ATCC 55365	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	"Has bacteriocidal activity against both aerobic and anaerobic Gram-positive bacteria. Has poor activity against Gram-negative bacteria, with the exception of B.fragilis. Inhibits bacterial protein biosynthesis by acting on elongation factor Tu. Full antibiotic activity depends on the presence of the modified residue Ile-50."	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Elongation Factor Tu  (EF-Tu)	21788474	Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13053-8. 	"Young TS, Walsh CT."	Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.
DRAMP00182	DWTXWSXLVXAACSVELL	18	Thuricin-S (Bacteriocin)	P84763	Belongs to the class IId bacteriocin	Not found	Bacillus thuringiensis subsp. entomocidus (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Thuricin S has the same N-terminal sequence (DWTXWSXL) as bacthuricin F4 and thuricin 17, produced by Bacillus thuringiensis strains BUPM4 and NEB17, respectively, and could therefore be classified as a new subBelongs to the class IId bacteriocin."	"Gram-positive bacteria: Listeria monocytogenes, Bacillus subtilis and other Bacillus, Enterobacter cloacae, L. acidophilus, Lactococcus lactis, Pediococcus acidilactici, S. thermophilus;##Gram-negative bacteria: S. cholerae, Shigella flexneri and Pseudomonas aeruginosa."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17496978	Can J Microbiol. 2007 Feb;53(2):284-290.	"Chehimi S, Delalande F, Sabl? S, Hajlaoui MR, Van Dorsselaer A, Limam F, Pons AM."	"Purification and partial amino acid sequence of thuricin S, a new anti-Listeria bacteriocin from Bacillus thuringiensis."
DRAMP00186	KRKCPKTPFDNTPGAWFAHLILGC	24	LSEI_2163 (m2163; Bacteriocin)	No entry found	Belongs to the class IId bacteriocin	Not found	Lactobacillus casei ATCC 334 (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: mature LSEI_2163 peptide was a class IId bacteriocin that exhibited antimicrobial activity against some lactobacilli and several Listeria species. The activities of both peptides tolerat 121¡ãC for 30 min but not treatment with proteinase K or trypsin.	"Gram-negative bacteria: Lactobacillus casei ATCC 393 (++), L. casei ATCC 27139 (++), Lactobacillus rhamnosus ATCC 21052 (+++++), L. rhamnosus ATCC 14957 (+), Lactobacillus plantarum ATCC 8014 (+), Listeria innocua ATCC 33091 (++), L. innocua CIP 78.44 (++), Listeria monocytogens ATCC 19112 (+++), Listeria welshimeri ATCC 43551 (++), Listeria seeligeri CIP79.46 (++++).##Note: + indistinct inhibit zone with diameter 8-12 mm, ++ indistinct inhibit zone with diameter ¡Ý12 mm, +++ clear inhibit zone with diameter 12-16 mm, ++++ clear inhibit zone with diameter 16-20 mm, and +++++ clear inhibit zone with diameter ¡Ý20 mm."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22688903	Appl Microbiol Biotechnol. 2012 Jun 12.	"Kuo YC, Liu CF, Lin JF, Li AC, Lo TC, Lin TH."	Characterization of putative class II bacteriocins identified from a non-bacteriocin-producing strain Lactobacillus casei ATCC 334.
DRAMP00187	DSIRDVSPTFNKIRRWFDGLFK	22	LSEI_2386 (m2386; Bacteriocin)	No entry found	Belongs to the class IId bacteriocin	Not found	Lactobacillus casei ATCC 334 (Gram-positive bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: mature LSEI_2386 was a putative pheromone peptide that also had significant bacteriocin activity against several Listeria species. The activities of both peptides tolerat 121¡ãC for 30 min but not treatment with proteinase K or trypsin.	"Gram-negative bacteria: Listeria innocua ATCC 33091 (++++), L. innocua CIP 78.44 (++++), Listeria monocytogens ATCC 19112 (+++++), Listeria welshimeri ATCC 43551 (+++++), Listeria seeligeri CIP79.46 (+++++).##Note: ++++ clear inhibit zone with diameter 16-20 mm, and +++++ clear inhibit zone with diameter ¡Ý20 mm."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22688903	Appl Microbiol Biotechnol. 2012 Jun 12.	"Kuo YC, Liu CF, Lin JF, Li AC, Lo TC, Lin TH."	Characterization of putative class II bacteriocins identified from a non-bacteriocin-producing strain Lactobacillus casei ATCC 334.
DRAMP00192	MRTGNAN	7	"Microcin C7 (MccC7; Microcin C51, MccC51; Bacteriocin)"	Q47505	Belongs to the class I microcin	mccA	Escherichia coli (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Beta strand	Not found	"3H5R, 3H9J, 3H9Q, 3H9G resolved by X-ray."	"Function: Inhibits protein translation by blocking aspartyl-tRNA synthetase Function: and inhibiting production of aminoacetylated tRNA-Asp. PTM: The peptide moiety allows entry into the bacterial cell, where it undergoes proteolytic cleavage to release the aspartyl adenylate analog, which is responsible for aspartyl-tRNA synthetase inhibition. Can be processed by the non-specific oligopeptidases pepA, pepB and pepN."	"Gram-negative bacteria: Enterobacteria including species of Klebsiella, Salmonella, Shigella, Yersinia and Proteus, strains of Escherichia coli."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	It targets the aspartyl-tRNA synthetase 	17827970##17711420##19494832	J Mol Microbiol Biotechnol. 2007;13(4):200-209.##Mol Microbiol. 2007 Sep;65(6):1380-1394.##EMBO J. 2009 Jul 8;28(13):1953-1964.	"Duquesne S, Petit V, Peduzzi J, Rebuffat S.##Severinov K, Semenova E, Kazakov A, Kazakov T, Gelfand MS.##Regni CA, Roush RF, Miller DJ, Nourse A, Walsh CT, Schulman BA."	"Structural and functional diversity of microcins, gene-encoded antibacterial peptides from enterobacteria.##Low-molecular-weight post-translationally modified microcins.##How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic."
DRAMP00195	ASGRDIAMAIGTLSGQFVAGGIGAAAGGVAGGAIYDYASTHKPNPAMSPSGLGGTIKQKPEGIPSEAWNYAAGRLCNWSPNNLSDVCL	88	Colicin-V (Microcin-V; Bacteriocin)	P22522	Belongs to the class IIa microcin	cvaC	Escherichia coli (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Colicin V kills sensitive cells by disrupting the membrane potential. It targets bacterial membranes and induces ion channel formation, leading to the disruption of the proton-motive force and hence ATP production.
PTM: Contains one disulfide bond between 76-87."	"Gram-negative bacteria: Escherichia coli (also closely related bacteria), Enterobacteriaceae."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	8204625##7952189##2249654	Biochemistry. 1994 Jun 7;33(22):6911-6917.##Microbiology. 1994 Sep;140 (Pt 9):2383-2389.##EMBO J. 1990 Dec;9(12):3875-3884.	"Fath MJ, Zhang LH, Rush J, Kolter R.##H?varstein LS, Holo H, Nes IF.##Gilson L, Mahanty HK, Kolter R."	Purification and characterization of colicin V from Escherichia coli culture supernatants.##The leader peptide of colicin V shares consensus sequences with leader peptides that are common among peptide bacteriocins produced by Gram-positive bacteria.##Genetic analysis of an MDR-like export system: the secretion of colicin V.
DRAMP00196	GDVNWVDVGKTVATNGAGVIGGAFGAGLCGPVCAGAFAVGSSAAVAALYDAAGNSNSAKQKPEGLPPEAWNYAEGRMCNWSPNNLSDVCL	90	Microcin L (MccL; Bacteriocin)	Q841V4	Belongs to the class IIa microcin	mclC	Escherichia coli (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Predicted	Not found	Not found	None	"It targets bacterial membranes and induces ion channel formation, leading to the disruption of the proton-motive force and hence ATP production."	"Gram-negative bacteria: Escherichia coli, Klebsiella oxytoca CIP666, Salmonella enterica serovar Agon, S. enterica serovar Braenderup, S. enterica serovar Brandenburg, S. enterica serovar Bredeney, S. enterica serovar Derby, S. enterica serovar Dublin, S. enterica serovar Enteritidis ATCC 13076, S. enterica serovar Hadar, S. enterica serovar Heildeberg, S. enterica serovar Indiana, S. enterica serovar Kottbus, S. enterica serovar Newport, S. enterica serovar St.Paul, S. enterica serovar Typhimurium CIP5858, S. enterica serovar Virchow, Shigella sonnei CIP5236, Shigella flexneri CIP5236, Pseudomonas aeruginosa CIP100720T, Pseudomonas aeruginosa ATCC 27853."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	14742202##12897830	Antimicrob Agents Chemother. 2004 Feb;48(2):505-513.##Can J Microbiol. 2003 May;49(5):357-361.	"Pons AM, Delalande F, Duarte M, Benoit S, Lanneluc I, Sabl? S, Van Dorsselaer A, Cottenceau G.##Sabl? S, Duarte M, Bravo D, Lanneluc I, Pons AM, Cottenceau G, Moreno F."	"Genetic analysis and complete primary structure of microcin L.##Wild-type Escherichia coli producing microcins B17, D93, J25, and L; cloning of genes for microcin L production and immunity."
DRAMP00197	AGDPLADPNSQIVRQIMSNAAWGPPLVPERFRGMAVGAAGGVTQTVLQGAAAHMPVNVPIPKVPMGPSWNGSKG	74	Microcin 24 (Mcc24; Bacteriocin)	Q46971	Belongs to the class IIa microcin	mtfS	Escherichia coli (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Homology	Not found	Not found	None	"MOA: It targets bacterial membranes and induces ion channel formation, leading to the disruption of the proton-motive force and hence ATP production."	"Gram-negative bacteria: Escherichia coli, Salmonella typhimurium."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.	"O'Brien G.J, Mahanty H.K."	Complete nucleotide sequence of microcin 24 genetic region and analysis of a new ABC transporter.
DRAMP00250	DYHHGVRVL	9	Bacteriocin serracin-P 43 kDa subunit (Bacteriocin)	P83375	Not found	Not found	Serratia plymuthica (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Major component of a prophage tail sheath. Antibacterial activity against Gram-negative bacteria E.amylovora.	Gram-negative bacterium: Erwinia amylovora.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12406768	Appl Environ Microbiol. 2002 Nov;68(11):5704-5710.	"Jabrane A, Sabri A, Comp¡§re P, Jacques P, Vandenberghe I, Van Beeumen J, Thonart P."	"Characterization of serracin P, a phage-tail-like bacteriocin, and its activity against Erwinia amylovora, the fire blight pathogen."
DRAMP00251	ALPKKLKYLNLFNDGFNYMGVV	22	Bacteriocin serracin-P 23 kDa subunit (Bacteriocin)	P83378	Not found	Not found	Serratia plymuthica J7 (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Major component of a prophage tail tube. Antibacterial activity against Gram-negative bacteria E.amylovora.	Gram-negative bacterium: Erwinia amylovora.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12406768	Appl Environ Microbiol. 2002 Nov;68(11):5704-5710.	"Jabrane A, Sabri A, Comp¡§re P, Jacques P, Vandenberghe I, Van Beeumen J, Thonart P."	"Characterization of serracin P, a phage-tail-like bacteriocin, and its activity against Erwinia amylovora, the fire blight pathogen."
DRAMP00341	ANTAFVSSAHNTQKIPAGAPFNRNLRAMLADLRQNAAFAG	40	"Antifungal protein ginkbilobin-1 (Ginkbilobin, GNL; Plants)"	P83171	Not found	GNK1	Ginkgo biloba (Ginkgo) (Maidenhair tree)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal"	Protein level	Not found	Not found	None	Function: Also inhibits HIV-1 reverse transcriptase and proliferation of murine splenocytes.	"Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli.##Fuungi: Botrytis cinerea, Mycosphaerella arachidicola, Fusarium oxysporum, Rhizoctonia solani, Coprinus comatus,"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11118300	Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411.	"Wang H, Ng T.B."	"Ginkbilobin, a novel antifungal protein from Ginkgo biloba seeds with sequence similarity to embryo-abundant protein."
DRAMP00393	IQCGESCVWIPCISSAWGCSCKNKICSS	28	Hedyotide B2 (hB2; Uncyclotides; Plants)	No entry found	Not found	Not found	Hedyotis biflora (aerial tissues)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Possesses antifungal activity.	"Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Streptococcus salivarius(MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M), Streptococcus aureus (MIC>80 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21979955	J Biol Chem. 2011 Dec 30;286(52):44833-44844.	"Nguyen GK, Zhang S, Wang W, Wong CT, Nguyen NT, Tam JP."	Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry.
DRAMP00397	KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKPPAHRCICYYEC	50	Defensin D1 (Ns-D1; Plant defensin)	P86972	Belongs to the DEFL family	Not found	Nigella sativa (Black cumin)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Antimicrobial peptide active against fungi, Gram-positive and Gram-negative bacteria. Has no effect on spore germination. Destroys spores in germinated conidia by disruption of cell walls and membranes in A. niger and B. sorokiniana. Causes vacuolization of germinated macro- and microconidia in F. oxysporum, F. graminearum and F. culmorum. Strongly inhibits growth of P. infestans on potato tubers above concentrations of 13.6 ?g/ml.
PTM: Contains four disulfide bonds."	"Fungi: Aspergillus niger (IC50=3.5 ?g/ml), Bipolaris sorokiniana (IC50=3.0 ?g/ml), Fusarium oxysporum (IC50=9.5 ?g/ml), Fusarium graminearum (IC50=6.9 ?g/ml), Fusarium culmorum (IC50=6.9 ?g/ml) and Botrytis cinerea (IC50=27.4 ?g/ml).##Gram-positive bacteria: Clavibacter michiganensis (1.4 cm) and Bacillus subtilis (1.3 cm);##Gram-negative bacteria: Pseudomonas syringae (0.9 cm), Erwinia carotovora (0.7 cm) and Escherichia coli (1.2 cm).##NOTE: Inhibition zone; Defensin concentration (11 ?g in 50 ??l)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21144761	Plant Physiol Biochem. 2011 Feb;49(2):131-137.	"Rogozhin EA, Oshchepkova YI, Odintsova TI, Khadeeva NV, Veshkurova ON, Egorov TA, Grishin EV, Salikhov SI."	Novel antifungal defensins from Nigella sativa L. seeds.
DRAMP00398	KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKLPAHRCICYYEC	50	Defensin D2 (Ns-D2; Plant defensin)	P86973	Belongs to the DEFL family	Not found	Nigella sativa (Black cumin)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Antimicrobial peptide active against fungi, Gram-positive and Gram-negative bacteria. Has no effect on spore germination. Destroys spores in germinated conidia by disruption of cell walls and membranes in Aspergillus niger and B.sorokiniana. Causes vacuolization of germinated macro- and microconidia in Fusarium oxysporum, F.graminearum and F.culmorum. Strongly inhibits growth of P.infestans on potato tubers above concentrations of 3.4 ?g/ml.
PTM: Contains four disulfide bonds."	"Fungi: Aspergillus niger (IC50=3.5 ?g/ml), Bipolaris sorokiniana (IC50=1.8 ?g/ml), Fusarium oxysporum (IC50=5.3 ?g/ml), Fusarium graminearum (IC50=6.9 ?g/ml), Fusarium culmorum (IC50=6.9 ?g/ml) and Botrytis cinerea (IC50=13.7 ?g/ml).##Gram-positive bacteria: Clavibacter michiganensis (1.5 cm) and Bacillus subtilis (1.3 cm);##Gram-negative bacteria: Pseudomonas syringae (1.3 cm), Erwinia carotovora (0.7 cm) and Escherichia coli (1.4 cm).##NOTE: Inhibition zone; Defensin concentration (11 ?g in 50 ??l)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21144761	Plant Physiol Biochem. 2011 Feb;49(2):131-137.	"Rogozhin EA, Oshchepkova YI, Odintsova TI, Khadeeva NV, Veshkurova ON, Egorov TA, Grishin EV, Salikhov SI."	Novel antifungal defensins from Nigella sativa L. seeds.
DRAMP00402	XTCESPSHKFKGPCATNRNCES	22	Defensin D1 (So-D1; Antimicrobial peptide D1; Plant defensin)	P81572	Belongs to the DEFL family	Not found	Spinacia oleracea (Spinach)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide. Active against Gram-positive and Gram-negative bacterial pathogens.	Gram-positive bacterium: Clavibacter michiganensis;##Gram-negative bacterium: Ralstonia solanacearum.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9762899	FEBS Lett. 1998; 435: 159-162.	"Segura A, Moreno M, Molina A, Garc?a-Olmedo F."	Novel defensin subfamily from spinach (Spinacia oleracea).
DRAMP00403	GIFSSRKCKTPSKTFKGICTRDSNCDTSCRYEGYPAGDCKGIRRRCMCSKPC	52	Defensin D2 (So-D2; Antimicrobial peptide D2; Plant defensin)	P81571	Belongs to the DEFL family	Not found	Spinacia oleracea (Spinach)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens.
Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots.
Developmental stage: Present throughout the life of the leaf.
PTM: Contains four disulfide bonds (By similarity)."	Gram-positive bacterium: Clavibacter michiganensis;##Gram-negative bacterium: Ralstonia solanacearum.##Fungi: Fusarium culmorum.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9762899	FEBS Lett. 1998; 435: 159-162.	"Segura A, Moreno M, Molina A, Garc?a-Olmedo F."	Novel defensin subfamily from spinach (Spinacia oleracea).
DRAMP00406	MFFSSKKCKTVXKTFRGPCVRNAN	24	Defensin D5 (So-D5; Antimicrobial peptide D5; Plant defensin)	P81568	Belongs to the DEFL family	Not found	Spinacia oleracea (Spinach)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens.
Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots.
Developmental stage: Present throughout the life of the leaf."	"Gram-positive bacterium: Clavibacter michiganensis;##Gram-negative bacterium: Ralstonia solanacearum.##Fungi: Fusarium culmorum, Fusarium solani, Bipolaris maydis and Colletotrichum lagenarium."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9762899	FEBS Lett. 1998; 435: 159-162.	"Segura A, Moreno M, Molina A, Garcia-Olmedo F."	Novel defensin subfamily from spinach (Spinacia oleracea).
DRAMP00407	GIFSNMYXRTPAGYFRGPXGYXXN	24	Defensin D6 (So-D6; Antimicrobial peptide D6; Plant defensin)	P81567	Belongs to the DEFL family	Not found	Spinacia oleracea (Spinach)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens.
Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots.
Developmental stage: Present throughout the life of the leaf."	Gram-positive bacterium: Clavibacter michiganensis (EC50=1 ?M);##Gram-negative bacterium: Ralstonia solanacearum (EC50=6 ?M).##Fungi: Fusarium solani (EC50=11 ?M). 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9762899	FEBS Lett. 1998; 435: 159-162.	"Segura A, Moreno M, Molina A, Garcia-Olmedo F."	Novel defensin subfamily from spinach (Spinacia oleracea).
DRAMP00409	KTCENLADTY	10	Defensin-like protein (Sesquin; Plant defensin)	P84868	Belongs to the DEFL family	Not found	Vigna unguiculata subsp. sesquipedalis (Yard-Long bean) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal"	Protein level	Not found	Not found	None	Function: Has antifungal and antibacterial activity. Has mitogenic activity towards murine splenocytes. Inhibits the proliferation of M1 leukemia and MCF-7 breast cancer cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase.	"Fungi: Botrytis cinerea (IC50=2.5¡À0.01 ?M), Fusarium oxysporum (IC50=1.4¡À0.02 ?M), Mycosphaerella arachidicola (IC50=0.15¡À0.002 ?M).##Gram-positive bacteria: Bacillus megaterium, Mycobacterium phlei;##Gram-negative bacteria: Escherichia coli, Proteus vulgaris."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15949629	Peptides. 2005 Jul;26(7):1120-1126.	"Wong JH, Ng TB"	"Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase."
DRAMP00455	LLGRCKVKSNRFNGPCLTDTHCSTVCRGEGYKGGDCHGLRRRCMCLC	47	Defensin-like protein 2 (Fabatin-2; Plant defensin)	P81457	Belongs to the DEFL family	Not found	Vicia faba (Broad bean)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Fabatins have antibacterial activity against Gram-positive and Gram-negative bacteria, but were inactive against the yeasts Saccharomyces cerevisiae and Candida albicans. High activity against P. aeruginosa.
PTM: Contains four disulfide bonds 5-47; 16-36; 22-43; 26-45."	"Gram-positive bacteria: Bacillus subtilis, Enterococcus hirae;##Gram-negative bacterium: Pseudomonas aeruginosa."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	9103978	FEMS Microbiol Lett. 1997 Apr 1;149(1):59-64.	"Zhang Y, Lewis K."	Fabatins: new antimicrobial plant peptides.
DRAMP00456	LLGRCKVKSNRFHGPCLTDTHCSTVCRGEGYKGGDCHGLRRRCMCLC	47	Defensin-like protein 1 (Fabatin-1; Plant defensin)	P81456	Belongs to the DEFL family	Not found	Vicia faba (Broad bean)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Fabatins have antibacterial activity against Gram-positive and Gram-negative bacteria, but were inactive against the yeasts Saccharomyces cerevisiae and Candida albicans. High activity against P. aeruginosa.
PTM: Contains four disulfide bonds 5-47; 16-36; 22-43; 26-45."	"Gram-positive bacteria: Bacillus subtilis, Enterococcus hirae;##Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	9103978	FEMS Microbiol Lett. 1997 Apr 1;149(1):59-64.	"Zhang Y, Lewis K."	Fabatins: new antimicrobial plant peptides.
DRAMP00746	RECKTESNTFPGICITKPPCRKACISEKFTDGHCSKILRRCLCTKPC	47	Flower-specific defensin (NaD1; Plant defensin)	Q8GTM0	Belongs to the DEFL family	D1	Nicotiana alata (Winged tobacco) (Persian tobacco)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Combine helix and strand structure	NaD1 adopts the cysteine-stabilized ¦Á¦Â (CS¦Á¦Â) motif formed by a triple-stranded antiparallel ¦Â-sheet and a single ¦Á-helix that is tethered to the sheet via three disulfide bonds. The fourth disulfide bond reinforces the N- and C-terminal regions of the molecule. 	"4AAZ, 4AB0 resolved by X-ray."	"Function: NaD1 is a member of a family of cationic peptides that displays growth inhibitory activity against several filamentous fungi, including Fusarium oxysporum.
PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43.
Tissue specificity: Most abundant in the epidermal cell layers of the petals and sepals, within the connective cells of the anthers, and the cortical cells of the style. Not detected in the tapetum, pollen mother cells, the transmitting tissue, the vascular bundles of the anther and style or in leaves. Expressed also in ovaries, but barley detectable in roots.
Biophysicochemical properties: pH dependence (Stable under extremes of pH); Temperature dependence (Stable under extremes of temperature."	"Fungi: Fusarium oxysporum f. sp. Vasinfectum (IC50=1 ?M), Thielaviopsis basicola (IC50=0.80 ?M), Verticillium dahliae (IC50=0.75 ?M), Leptosphaeria maculans (IC50=0.80 ?M), Aspergillus nidulans (IC50=0.80 ?M), Candida albicans (IC50>10 ?M), Pichia pastoris (IC50>10 ?M), Saccharomyces cerevisiae (IC50>10 ?M).##Gram-negative bacteria: Escherichia coli (IC50>10 ?M), Pseudomonas aeruginosa (IC50>10 ?M);##Gram-positive bacteria: Staphylococcus aureus (IC50>10 ?M), Bacillus cereus (IC50>10 ?M).##HeLa cells (IC50>10 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12644678##12473460##22511788##18339623	Plant Physiol. 2003 Mar;131(3):1283-1293.##J Mol Biol. 2003 Jan 3;325(1):175-188.##J Biol Chem. 2012 Jun 8;287(24):19961-72.##J Biol Chem. 2008 May 23;283(21):14445-52.	"Lay FT, Brugliera F, Anderson MA.##Lay FT, Schirra HJ, Scanlon MJ, Anderson MA, Craik DJ.##Lay FT, Mills GD, Poon IK, Cowieson NP, Kirby N, Baxter AA, van der Weerden NL, Dogovski C, Perugini MA, Anderson MA, Kvansakul M, Hulett MD.##van der Weerden NL, Lay FT, Anderson MA."	"Isolation and properties of floral defensins from ornamental tobacco and petunia.##The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP.##Dimerization of plant defensin NaD1 enhances its antifungal activity.##The plant defensin, NaD1, enters the cytoplasm of Fusarium oxysporum hyphae."
DRAMP00767	GDACGETCFTGICFTAGCSCNPWPTCTRN	29	ChaC1 (Chassatide C1; Plant defensin)	No entry found	Belongs to the cyclotide family	Not found	Chassalia chartacea	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"IC50=9.8 ?M, HD50=51.9 ?M.##Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)."	"Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)."	[Ref.22467870] HD50=51.9 ?M against human type A red blood cells.	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys 4 and Cys18, Cys8 and Cys20,  Cys13 and Cys26 ."	L	[Ref.22467870] Cytotoxicity: HeLa cells (IC50=9.8 ?M).	Not found	22467870	J Biol Chem. 2012 May 18;287(21):17598-17607.	"Nguyen GK, Lim WH, Nguyen PQ, Tam JP."	Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.
DRAMP00768	GIPCAESCVWIPPCTITALMGCSCKNNVCYNN	32	ChaC2 (Chassatide C2; Plant defensin)	No entry found	Belongs to the cyclotide family	Not found	Chassalia chartacea	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"IC50=2.4 ?M, HD50>25 ?M.##Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)."	"Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)."	[Ref.22467870] HD50>25 ?M against human type A red blood cells.	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys 4 and Cys21, Cys8 and Cys23,  Cys13 and Cys28."	L	[Ref.22467870] Cytotoxicity: HeLa cells (IC50=2.4 ?M).	Not found	22467870	J Biol Chem. 2012 May 18;287(21):17598-17607.	"Nguyen GK, Lim WH, Nguyen PQ, Tam JP."	Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.
DRAMP00769	GASCGETCFTGICFTAGCSCNPWPTCTRN	29	ChaC4 (Chassatide C4; Plant defensin)	No entry found	Belongs to the cyclotide family	Not found	Chassalia chartacea	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"IC50=9.8 ?M, HD50=51.9 ?M.##Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)."	"Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)."	[Ref.22467870] HD50=51.9 ?M against human type A red blood cells.	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys 4 and Cys18, Cys8 and Cys20,  Cys13 and Cys26 ."	L	[Ref.22467870] Cytotoxicity: HeLa cells (IC50=9.8 ?M).	Not found	22467870	J Biol Chem. 2012 May 18;287(21):17598-17607.	"Nguyen GK, Lim WH, Nguyen PQ, Tam JP."	Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.
DRAMP00770	GEYCGESCYLIPCFTPGCYCVSRQCVNKN	29	ChaC10 (Chassatide C10; Plant defensin)	No entry found	Belongs to the cyclotide family	Not found	Chassalia chartacea	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"IC50=5.0 ?M, HD50>25 ?M.##Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)."	"Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)."	[Ref.22467870] HD50>25 ?M against human type A red blood cells.	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys 4 and Cys18, Cys8 and Cys20,  Cys13 and Cys25 ."	L	[Ref.22467870] Cytotoxicity: HeLa cells (IC50=5.0 ?M).	Not found	22467870	J Biol Chem. 2012 May 18;287(21):17598-17607.	"Nguyen GK, Lim WH, Nguyen PQ, Tam JP."	Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.
DRAMP18325	MAADIISTIGDLVKLIINTVKKFQK	25	delta-lysin I (Bacteriocin)	No entry found	Not found	Not found	Staphylococcus warneri RK	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Warnericin RK and delta-lysin I displayed the same antibacterial spectrum, which is almost restricted to the Legionella genus. Also, both peptides have a hemolytic activity."	"[Ref.18339450]Gram-positive bacteria:?Bacillus megaterium?F04(+),?Bacillus subtilis(¨C),?Enterococcus faecalis?V583(¨C),?Listeria monocytogenes?EGDe(¨C),?Micrococcus luteus(¨C),?Pediococcus acidilactici?583(¨C),?Staphylococcus aureus?971(¨C),?Staphylococcus chromogenes(¨C),?Staphylococcus cohnii?898(¨C),?Staphylococcus epidermidis?567(-),?Staphylococcus haemolyticus?694(-),?Staphylococcus hominis?373(-),?Staphylococcus lentus 982(-), Staphylococcus lugdunensis?967(-),?Staphylococcus saprophyticus?715(-),?Staphylococcus warneri?447(-),?Staphylococcus warneri?RK(-);## Gram-negative bacteria: ?Enterobacter cloacae?D03(-),?Escherichia coli?MG1655(-),?Hafnia alvei(-),?Klebsiella pneumoniae?0502083(-),?Legionella bozemanii?ATCC 33217(+), ?Legionella dumofii?ATCC 33279(+),?Legionella feeleii?ATCC 35072(+),?Legionella like bacteria (LLAP10)(+),?Legionella longbeachae?ATCC 33484(+),?Legionella micdadei?ATCC 33218(+),?Legionella oakridgensis?ATCC 33761(+),?Legionella pneumophila?Corby (sg1)(+),?Legionella pneumophila?Lens (sg1)(+),?Legionella pneumophila?Paris (sg1)(+),?Legionella pneumophila?ATCC 33155 (sg3)(+),?Legionella pneumophila?ATCC 33216 (sg5)(+),?Legionella pneumophila?ATCC 33215 (sg6)(+),?Proteus mirabilis?ATCC 35659(-),?Pseudomonas aeruginosa?DSMZ1128(-),?Pseudomonas aeruginosa?910704(-),?Salmonella typhimurium(-)"	"[Ref.18339450]10% hemolytic activity at 1.56 ¦ÌM, 40% hemolytic activity at 6.25 ¦ÌM, 62% hemolytic activity at 25 ¦ÌM, 80% hemolytic activity at 50 ¦ÌM against human erythrocytes "	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18339450	Peptides. 2008 Jun;29(6):978-84. 	"Verdon J, Berjeaud JM, Lacombe C, H"	Characterization of anti-Legionella activity of warnericin RK and delta-lysin I from Staphylococcus warneri.
DRAMP00796	GEFLKCGESCVQGECYTPGCSCDWPICKKN	30	Cliotide T2 (cT2; Plant defensin)	No entry found	Belongs to the cyclotide family	Not found	Clitoria ternatea (Butterfly pea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	Function: Cliotide T2 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. Cliotide T2 was relatively nonhemolytic (HD50>100 ?M) .	"[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC>100 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC>100 ?M), Klebsiella pneumonia ATCC 13883 (MIC>100 ?M)."	[Ref:21596752] HD50>100 ?M against human type A erythrocytes	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys I and CysIV, CysII and CysV,  CysIII and CysVI."	L	[Ref.21596752] Cytotoxicity: HeLa Cells (IC50=8.0 ?M).	Not found	21596752	J Biol Chem. 2011 Jul 8;286(27):24275-24287.	"Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP."	Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family.
DRAMP00797	GLPTCGETCTLGTCYVPDCSCSWPICMKN	29	Cliotide T3 (cT3; Plant defensin)	No entry found	Belongs to the cyclotide family	Not found	Clitoria ternatea (Butterfly pea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"Function: Cliotide T3 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=13.1 ?M) and cytotoxicity against HeLa Cells (IC50=2.0 ?M).
[Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. "	"[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC>100 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC>100 ?M), Klebsiella pneumonia ATCC 13883 (MIC>100 ?M)."	[Ref:21596752] HD50=13.1 ?M against human type A erythrocytes	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys I and CysIV, CysII and CysV,  CysIII and CysVI."	L	[Ref.21596752] Cytotoxicity: HeLa Cells (IC50=2.0 ?M).	Not found	21596752	J Biol Chem. 2011 Jul 8;286(27):24275-24287.	"Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP."	Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family.
DRAMP18324	MQFITDLIKKAVDFFKGLFGNK	22	Warnericin RK (Bacteriocin)	No entry found	Not found	Not found	Staphylococcus warneri RK	"Antimicrobial, Antibacterial, Anti-Gram-"		Alpha Helix	Not found	None	Warnericin RK acts as a specific anti-Legionella AMP by permeabilizing the bacterial membrane.	Gram-negative(Narrow)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18339450##19804724 	Peptides. 2008 Jun;29(6):978-84.##Biophys J. 2009 Oct 7;97(7):1933-40. 	"Verdon J, Berjeaud JM, Lacombe C, H"	"Characterization of anti-Legionella activity of warnericin RK and delta-lysin I from Staphylococcus warneri.##Detergent-like activity and alpha-helical structure of warnericin RK, an anti-Legionella peptide."
DRAMP00937	KSCCRNTVARNCYNVCRIPGTPRPVCAATCDCKLITGTKCPPGYEK	46	Tu-AMP1 (Plant defensin)	No entry found	Belongs to the thionin family	Not found	Tulipa gesneriana L. 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Bacteria: Erwinia carotovora (IC50=11 ?g/ml), Agrobacterium radiobacter (IC50=15 ?g/ml), Agrobacterium rhizogenes (IC50=20 ?g/ml);##Gram-positive bacteria: Clavibacter michiganensis (IC50=14 ?g/ml), Curtobacterium flaccumfaciens (IC50=13 ?g/ml).##Fungi: Fusarium oxysporum (IC50=2 ?g/ml), Geotrichum candidum (IC50=2 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	15056889	Biosci Biotechnol Biochem. 2004 Mar;68(3):571-577.	"Fujimura M, Ideguchi M, Minami Y, Watanabe K, Tadera K."	"Purification, characterization, and sequencing of novel antimicrobial peptides, Tu-AMP 1 and Tu-AMP 2, from bulbs of tulip (Tulipa gesneriana L.)."
DRAMP00938	KSCCRNTTARNCYNVCRIPG	20	Tu-AMP2 (Plant defensin)	No entry found	Belongs to the thionin family	Not found	Tulipa gesneriana L. 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Erwinia carotovora (IC50=15 ?g/ml), Agrobacterium radiobacter (IC50=17 ?g/ml), Agrobacterium rhizogenes (IC50=20 ?g/ml);##Gram-positive bacteria: Clavibacter michiganensis (IC50=17 ?g/ml), Curtobacterium flaccumfaciens (IC50=15 ?g/ml).##Fungi: Fusarium oxysporum (IC50=2 ?g/ml), Geotrichum candidum (IC50=2 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15056889	Biosci Biotechnol Biochem. 2004 Mar;68(3):571-577.	"Fujimura M, Ideguchi M, Minami Y, Watanabe K, Tadera K."	"Purification, characterization, and sequencing of novel antimicrobial peptides, Tu-AMP 1 and Tu-AMP 2, from bulbs of tulip (Tulipa gesneriana L.)."
DRAMP00957	KSCCRSTQARNIYNAPRFAGGSRPLCALGSGCKIVDDKKTPPND	44	Pp-AMP1 (P. pubescens AMP1; Plant defensin)	No entry found	Belongs to the thionin family	Not found	Phyllostachys pubescens (Japanese bamboo shoots)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Bridge 	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Erwinia carotovora (IC50=22 ?g/ml), Agrobacterium radiobacter (IC50=15 ?g/ml), Agrobacterium rhizogenes (IC50=15 ?g/ml);##Gram-positive bacteria: Clavibacter michiganensis (IC50=14 ?g/ml), Curtobacterium flaccumfaciens (IC50=25 ?g/ml).##Fungi: Fusarium oxysporum (IC50=2 ?g/ml), Geotrichum candidum (IC50=2 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	15784998	Biosci Biotechnol Biochem. 2005 Mar;69(3):642-645.	"Fujimura M, Ideguchi M, Minami Y, Watanabe K, Tadera K."	"Amino acid sequence and antimicrobial activity of chitin-binding peptides, Pp-AMP 1 and Pp-AMP 2, from Japanese bamboo shoots (Phyllostachys pubescens)."
DRAMP00958	KSCCRSTTARNIYNGCRVPGTARPVCAKKSGCKIQEAKKCEPPYD	45	Pp-AMP2 (P. pubescens AMP2; Plant defensin)	No entry found	Belongs to the thionin family	Not found	Phyllostachys pubescens (Japanese bamboo shoots)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Bridge 	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Erwinia carotovora (IC50=20 ?g/ml), Agrobacterium radiobacter (IC50=13 ?g/ml), Agrobacterium rhizogenes (IC50=15 ?g/ml);##Gram-positive bacteria: Clavibacter michiganensis (IC50=18 ?g/ml), Curtobacterium flaccumfaciens (IC50=20 ?g/ml).##Fungi: Fusarium oxysporum (IC50=2 ?g/ml), Geotrichum candidum (IC50=2 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	15784998	Biosci Biotechnol Biochem. 2005 Mar;69(3):642-645.	"Fujimura M, Ideguchi M, Minami Y, Watanabe K, Tadera K."	"Amino acid sequence and antimicrobial activity of chitin-binding peptides, Pp-AMP 1 and Pp-AMP 2, from Japanese bamboo shoots (Phyllostachys pubescens)."
DRAMP01380	GLFTLIKCAYQLIAPTVACN	20	"Odorranain-J1 (OdJ1; Frogs, amphibians, animals)"	A6MBN6	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Odorranain-J1 adopts 50.1% ¦Â-sheet and 13.7% turn structure in water solution.	None	Function: Odorranain-J1 exhibites moderate antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=35.60 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=17.80 ¦Ìg/ml), Bacillus subtilis (MIC=35.60 ¦Ìg/ml).##Yeast: Candida albicans (MIC=8.90 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP00980	AQRCGDQARGAKCPNCLCCGKYGFCGSGDAYCGAGSCQSQCRGC	44	Antimicrobial peptide 1a (WAMP-1a; Plant defensin)	P85966	Belongs to the hevein-like family	Not found	Triticum kiharae (wheat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Combine helix and strand structure	Not found	2LB7 resolved by NMR.	PTM: Contains five disulfide bonds 4-19; 13-25; 16-44; 18-32; 37-41.	"Fungi: Bipolaris sorokiniana (IC50=5 ?g/ml), Botrytis cinerea (IC50=20 ?g/ml), Fusarium oxysporum (IC50=5 ?g/ml), Fusarium solani (IC50=5 ?g/ml), Fusarium verticillioides (IC50=30 ?g/ml), Neurospora crassa (IC50=10 ?g/ml);##Gram-positive bacterium: Clavibacter michiganensis (1.3cm inhibition for 2.5 ?g/50?l);##Gram-negative bacteria: Erwinia carotovora (1.1cm for 2.5 ?g/50?l), Pseudomonas syringae (0.9cm for 2.5 ?g/50?l)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	19583772##16269343	FEBS J. 2009 Aug;276(15):4266-4275.##Peptides. 2005 Nov;26(11):2064-2073.	"Odintsova TI, Vassilevski AA, Slavokhotova AA, Musolyamov AK, Finkina EI, Khadeeva NV, Rogozhin EA, Korostyleva TV, Pukhalsky VA, Grishin EV, Egorov TA.##Egorov TA, Odintsova TI, Pukhalsky VA, Grishin EV."	A novel antifungal hevein-type peptide from Triticum kiharae seeds with a unique 10-cysteine motif.##Diversity of wheat anti-microbial peptides.
DRAMP00981	AQRCGDQARGAKCPNCLCCGKYGFCGSGDAYCGAGSCQSQCRGCR	45	Antimicrobial peptide 1b (WAMP-1b; Plant defensin)	P85966	Belongs to the hevein-like family	Not found	Triticum kiharae (wheat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	PTM: Contains five disulfide bonds 4-19; 13-25; 16-44; 18-32; 37-41.	"Fungi: Bipolaris sorokiniana (IC50=5 ?g/ml), Botrytis cinerea (IC50=20 ?g/ml), Fusarium oxysporum (IC50=5 ?g/ml), F. solani (IC50=5 ?g/ml), F. verticillioides (IC50=30 ?g/ml), Neurospora crassa (IC50=10 ?g/ml);##Gram-positive bacterium: Clavibacter michiganensis (1.3cm inhibition for 2.5 ?g/50?l);##Gram-negative bacteria: Erwinia carotovora (1.1cm for 2.5 ?g/50?l), Pseudomonas syringae (0.9cm for 2.5 ?g/50?l)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	19583772##16269343	FEBS J. 2009 Aug;276(15):4266-4275.##Peptides. 2005 Nov;26(11):2064-2073.	"Odintsova TI, Vassilevski AA, Slavokhotova AA, Musolyamov AK, Finkina EI, Khadeeva NV, Rogozhin EA, Korostyleva TV, Pukhalsky VA, Grishin EV, Egorov TA.##Egorov TA, Odintsova TI, Pukhalsky VA, Grishin EV."	A novel antifungal hevein-type peptide from Triticum kiharae seeds with a unique 10-cysteine motif.##Diversity of wheat anti-microbial peptides.
DRAMP00982	AQCGAQGGGATCPGGLCCSQWGWCGSTPKYCGAGCQSNCK	40	Fa-AMP1 (Fagopyrum antimicrobial peptide 1; hevein-type; Plant defensin)	No entry found	Belongs to the hevein-like family	Not found	Fagopyrum esculentum Moench (buckwheat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Has antibacterial avtivity against Gram-positive bacteria and Gram-negative bacteria, also has antifungal activity."	"Gram-positive bacteria: Clavibacter michiganensis (IC50=14 ?g/ml), Curtobacterium accumfaciens (IC50=13 ?g/ml);##Gram-negative bacteria: Erwinia carotovora (IC50=11 ?g/ml), Agrobacterium radiobacter (IC50=24 ?g/ml), Agrobacterium rhizogenes (IC50=20 ?g/ml).##Fungi: Fusarium oxysporum (IC50=19 ?g/ml), Geotrichum candidum (IC50=36 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12951494	Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-1642.	"Fujimura M, Minami Y, Watanabe K, Tadera K."	"Purification, characterization, and sequencing of a novel type of antimicrobial peptides, Fa-AMP1 and Fa-AMP2, from seeds of buckwheat (Fagopyrum esculentum Moench.)."
DRAMP00983	AQCGAQGGGATCPGGLCCSQWGWCGSTPKYCGAGCQSNCR	40	Fa-AMP2 (Fagopyrum antimicrobial peptide 2; hevein-type; Plant defensin)	No entry found	Belongs to the hevein-like family	Not found	Fagopyrum esculentum Moench (buckwheat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Has antibacterial avtivity against Gram-positive bacteria and Gram-negative bacteria, also has antifungal activity."	"Gram-positive bacteria: Clavibacter michiganensis (IC50=17 ?g/ml), Curtobacterium accumfaciens (IC50=15 ?g/ml);##Gram-negative bacteria: Erwinia carotovora (IC50=15 ?g/ml), Agrobacterium radiobacter (IC50=17 ?g/ml), Agrobacterium rhizogenes (IC50=24 ?g/ml).##Fungi: Fusarium oxysporum (IC50=29 ?g/ml), Geotrichum candidum (IC50=25 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12951494	Biosci Biotechnol Biochem. 2003 Aug;67(8):1636-1642.	"Fujimura M, Minami Y, Watanabe K, Tadera K."	"Purification, characterization, and sequencing of a novel type of antimicrobial peptides, Fa-AMP1 and Fa-AMP2, from seeds of buckwheat (Fagopyrum esculentum Moench.)."
DRAMP00993	QAGGQTCPGGICCSQWGYCGTTADYCSPNNNCQSNCWASG	40	WjAMP-1 (C-terminal domain of hevein; Plant defensin)	No entry found	Not found	WjAMP-1	Wasabia japonica L. (Wasabi plant) (Wasabia japonica) 	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: WjAMP-1 showed antimicrobial activity against both fungi and bacteria.	"Gram-negative bacteria: Escherichia coli (IC50=27.5 ?g/ml), Pseudomonas cichorii (IC50=13.8 ?g/ml), Pseudomonas glumae (IC50=20 ?g/ml), Pseudomonas plantarii (IC50=22.5 ?g/ml), Agrobacterium tumefaciens (IC50=12.5 ?g/ml).##Fungi: Alternaria alternata (IC50=5.8 ?g/ml), Botrytis cinerea (IC50=15 ?g/ml), Fusarium solani (IC50=8.4 ?g/ml), Magnaporte grisea (IC50=80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	12668776	Plant Cell Physiol. 2003 Mar;44(3):296-303.	"Kiba A, Saitoh H, Nishihara M, Omiya K, Yamamura S."	C-terminal domain of a hevein-like protein from Wasabia japonica has potent antimicrobial activity.
DRAMP00997	QWGRRCCGWGPGRRYCRRWC	20	IB-AMP4 (IBAMP4; Basic peptide AMP4; Plants)	O24006	Not found	Not found	Impatiens balsamina (Balsam)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	Developmental stage: Highly expressed in dry mature seed and by the stages 2-5 of developing seed. PTM: Contains two disulfide bonds C6-C16; C7-C20 and Pyrrolidone carboxylic acid at position 1 (Probable). Note: Peptide IB-AMP4 has a higher antifungal act	"Gram-positive bacteria: Bacillus subtilis (IC50=5 ?g/ml), Micrococcus luteus (IC50=5 ?g/ml), Staphylococcus aureus (IC50=20 ?g/ml), Streptococcus faecalis (IC50=5 ?g/ml);##Gram-negative bacteria: Xanthomonas campestris (IC50=6 ?g/ml), Xanthomonas oryzae (IC50=15 ?g/ml).##Fungi: Alternaria longipes (IC50=3 ?g/ml), Botrytis cinerea (IC50=6 ?g/ml), Cladosporium sphaerospermum (IC50=1 ?g/ml), Fusarium culmorum (IC50=1 ?g/ml), Penicillium digitatum (IC50=3 ?g/ml), Trichoderma viride (IC50=6 ?g/ml), Verticillium alboatrum (IC50=6 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9305910##9454588	J Biol Chem. 1997 Sep 26;272(39):24480-24487.##Biochemistry. 1998 Jan 27;37(4):983-990.	"Tailor RH, Acland DP, Attenborough S, Cammue BP, Evans IJ, Osborn RW, Ray JA, Rees SB, Broekaert WF.##Patel SU, Osborn R, Rees S, Thornton JM."	A novel family of small cysteine-rich antimicrobial peptides from seed of Impatiens balsamina is derived from a single precursor protein.##Structural studies of Impatiens balsamina antimicrobial protein (Ib-AMP1).
DRAMP00998	RSGRGECRRQCLRRHEGQPWETQECMRRCRRRG	33	Antimicrobial peptide MBP-1 (Maize Basic Peptide 1; Plant defensin)	P28794	Not found	Not found	Zea mays (Maize)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Inhibitor of both bacterial and fungal growth in vitro.	"Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Corynebacterium nebraskense ssp.##Fungi: Fusarium graminearum, Fusarium moniliforme, Aspergillus flavus, Alonina longipes, Sclerotinia sclerotiorum, Sclerotinia trifoliorum. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1527010	J. Biol. Chem. 1992; 267:18814-18820	"Duvick JP, Rood T, Rao AG, Marshak DR.1992"	Purification and characterization of a novel antimicrobial peptide from maize (Zea mays L.) kernels.
DRAMP01009	DDFLCAGGCL	10	Alliumin (Plants)	P84796	Not found	Not found	Allium sativum (Garlic)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has antifungal activity against M.arachidicola with an IC50 of 1.3 ?M. Has antibacterial activity against the Gram-negative bacteria P. fluorescens. Has antiproliferative activity towards L1210 leukemia cells with an IC50 of 8.33 ?M.	Fungi: Mycosphaerella arachidicola (IC50=1.3 ?M).##Gram-negative bacterium: Pseudomonas fluorescens.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15629528	Peptides. 2005 Feb;26(2):177-183.	"Xia L, Ng TB."	"Isolation of alliumin, a novel protein with antimicrobial and antiproliferative activities from multiple-cloved garlic bulbs."
DRAMP01010	KTCENLADTFRGPCFATSNC	20	Lunatusin (Plants)	No entry found	Not found	Not found	Phaseolus lunatus L.(Chinese lima bean)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal"	Not found	Not found	Not found	None	Function: It also inhibited proliferation in the breast cancer cell line MCF-7. Lunatusin reduced the activity of HIV-1 reverse transcriptase and it also inhibited translation in a cell-free rabbit reticulocyte lysate system. Its anti-fungal activity was 	"Fungi: Fusarium oxysporum, Mycosphaerella arachidicola and Botrytis cinerea.##Gram-positive bacteria: Bacillus megaterium, Bacillus subtilis;##Gram-negative bacteria: Proteus vulgaris, Mycobacterium phlei."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16269344	Peptides. 2005 Nov;26(11):2086-2092.	"Wong JH, Ng TB."	"Lunatusin, a trypsin-stable antimicrobial peptide from lima beans (Phaseolus lunatus L.)."
DRAMP01015	RTCMKKEGWGKCLIDTTCAHSCKNRGYIGGNCKGMTRTCYCLVNC	45	VaD1 (Plant defensin)	No entry found	Not found	Not found	Vigna angularis Kao Hsiung No.6 (Seeds)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Fungi: Fusarium oxysporum, Fusarium oxysporum f. sp. Pisi.##Gram-positive bacterium: Staphylococcus epidermidis;##Gram-negative bacterium: Salmonella typhimurium."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15713009	J Agric Food Chem 2005; 53: 982-988.	"Chen G.-H. et al. Chen, C.-S."	Cloning and characterization of a plant defensin VaD1 from Azuki Bean.
DRAMP01022	KGAPCAKKPCCGPLGHYKVDCSTIPDYPCCSKYGFCGSGPQYCG	44	Cy-AMP1 (Plant defensin)	No entry found	Not found	Not found	Cycas revoluta (cycad seeds)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Cy-AMP1 has antimicrobial activity against various plant-pathogenic fungi and bacteria.	"Gram-positive bacteria: Clavibacterium michiganensis (IC50=7.3 ?g/ml), Curtobacterium ???accumfaciens (IC50=8.9 ?g/ml);##Gram-negative bacteria: Agrobacterium radiobacter (IC50=8.3 ?g/ml), Agrobacterium rhizogenes (IC50=8.5 ?g/ml), Erwinia carobora (IC50=8.0 ?g/ml).##Fungi: Fusarium oxysporum (IC50=6.0 ?g/ml), Geotrichum candidum (IC50=7.4 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipid-binding	18778743	Peptides. 2008 Dec;29(12):2110-2117.	"Yokoyama S, Kato K, Koba A, Minami Y, Watanabe K, Yagi F."	"Purification, characterization, and sequencing of antimicrobial peptides, Cy-AMP1, Cy-AMP2, and Cy-AMP3, from the Cycad (Cycas revoluta) seeds."
DRAMP01023	KGGPCAKKPCCGPLGHYKVDCSTIPDYPCCSKYGFCGSGPQYCG	44	Cy-AMP2 (Plant defensin)	No entry found	Not found	Not found	Cycas revoluta (cycad seeds)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Cy-AMP2 has antimicrobial activity against various plant-pathogenic fungi and bacteria.	"Gram-positive bacteria: Clavibacterium michiganensis (IC50=7.6 ?g/ml), Curtobacterium ???accumfaciens (IC50=8.3 ?g/ml);##Gram-negative bacteria: Agrobacterium radiobacter (IC50=7.8 ?g/ml), Agrobacterium rhizogenes (IC50=8.2 ?g/ml), Erwinia carobora (IC50=8.1 ?g/ml).##Fungi: Fusarium oxysporum (IC50=7.1 ?g/ml), Geotrichum candidum (IC50=7.0 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipid-binding	18778743	Peptides. 2008 Dec;29(12):2110-2117.	"Yokoyama S, Kato K, Koba A, Minami Y, Watanabe K, Yagi F."	"Purification, characterization, and sequencing of antimicrobial peptides, Cy-AMP1, Cy-AMP2, and Cy-AMP3, from the Cycad (Cycas revoluta) seeds."
DRAMP01024	AVTCNTVVSSLAPCVPFFAGSAAQPTAACCNGVRSLNSAARTTPDRRTACNCIKSSASSIGLNYNKAAKLPSRCTVNVTVPISPSVNCAT	90	Cy-AMP3 (Plant defensin)	No entry found	Not found	Not found	Cycas revoluta (cycad seeds)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Cy-AMP3 has weak antimicrobial activity against various plant-pathogenic fungi and bacteria.	"Gram-positive bacteria: Clavibacterium michiganensis (IC50=235 ?g/ml), Curtobacterium ???accumfaciens (IC50=195 ?g/ml);##Gram-negative bacteria: Agrobacterium radiobacter (IC50=260 ?g/ml), Agrobacterium rhizogenes (IC50=235 ?g/ml), Erwinia carobora (IC50=230 ?g/ml).##Fungi: Fusarium oxysporum (IC50=250 ?g/ml), Geotrichum candidum (IC50=200 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipid-binding	18778743	Peptides. 2008 Dec;29(12):2110-2117.	"Yokoyama S, Kato K, Koba A, Minami Y, Watanabe K, Yagi F."	"Purification, characterization, and sequencing of antimicrobial peptides, Cy-AMP1, Cy-AMP2, and Cy-AMP3, from the Cycad (Cycas revoluta) seeds."
DRAMP01046	GYGGHGGHGGHGGHGGHGGHGHGGGGHG	28	Shepherin I (fragement of shep-GRP; Plants)	No entry found	Not found	GRP	Capsella bursa-pastoris (shepherd's purse)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Not found	Not found	"Circular dichroism (CD) spectra of shepherin I showes that shepherin I in 50% trifluoroethanol has 66.7% random coils, without any alpha-helices."	None	"Function: These antimicrobial peptides exhibit antimicrobial activity against Gram-negative bacteria and fungi.
Tissue specificity: Expressed in roots but not in leaves and stems."	"Gram-negative bacteria: Erwinia herbicola (IC50=62 ?g/ml), Escherichia coli (IC50<2.5 ?g/ml), Pseudomonas putida (IC50<2.5 ?g/ml), Pseudomonas syringae (IC50<2.5 ?g/ml), Salmonella typhimurium (IC50<2.5 ?g/ml), Serratia sp. (IC50=8 ?g/ml).##Fungi: Candida albicans (IC50=8 ?g/ml), Cryptococcus neoformans (IC50<2.5 ?g/ml), Saccharomyces cerevisiae (IC50<7 ?g/ml), Alternaria alternata (IC50<7 ?g/ml), Aspergillus flavus (IC50=65 ?g/ml), Fusarium culmorum (IC50=72 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11117262	Plant Mol Biol. 2000 Sep;44(2):187-197.	"Park CJ, Park CB, Hong SS, Lee HS, Lee SY, Kim SC."	"Characterization and cDNA cloning of two glycine- and histidine-rich antimicrobial peptides from the roots of shepherd's purse, Capsella bursa-pastoris."
DRAMP01047	GYHGGHGGHGGGYNGGGGHGGHGGGYNGGGHHGGGGHG	38	shepherin II (fragement of shep-GRP; Plants)	No entry found	Not found	GRP	Capsella bursa-pastoris (shepherd's purse)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Not found	Not found	"Circular dichroism (CD) spectra of shepherin II showes that shepherin II in 50% trifluoroethanol has 75% random coils, without any alpha-helices."	None	"Function: These antimicrobial peptides exhibit antimicrobial activity against Gram-negative bacteria and fungi.
Tissue specificity: Expressed in roots but not in leaves and stems."	"Gram-negative bacteria: Erwinia herbicola (IC50=25 ?g/ml), Escherichia coli (IC50<2.5 ?g/ml), Pseudomonas putida (IC50<2.5 ?g/ml), Pseudomonas syringae (IC50<2.5 ?g/ml), Salmonella typhimurium (IC50=65 ?g/ml), Serratia sp. (IC50<2.5 ?g/ml).##Fungi: Candida albicans (IC50=5 ?g/ml), Cryptococcus neoformans (IC50<2.5 ?g/ml), Saccharomyces cerevisiae (IC50=3 ?g/ml), Aspergillus flavus (IC50=60 ?g/ml), Fusarium culmorum (IC50=68 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11117262	Plant Mol Biol. 2000 Sep;44(2):187-197.	"Park CJ, Park CB, Hong SS, Lee HS, Lee SY, Kim SC."	"Characterization and cDNA cloning of two glycine- and histidine-rich antimicrobial peptides from the roots of shepherd's purse, Capsella bursa-pastoris."
DRAMP01099	GIGAAILSAGKSIIKGLANGLAEHF	25	"Bombinin-like peptide 4 (BLP-4; toads, amphibians, animals)"	P29005	Belongs to the bombinin family	Not found	Bombina orientalis (Oriental fire-bellied toad)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Alpha helix	Not found	None	"Function: Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.
Tissue specificity: Expressed by the skin glands."	"[Ref.1744108]Gram-negative bacteria: Neisseria meningitidis, Neisseria gonorrhoeoe, Neisseria Iactamica, Neisseria cinerea."	[Ref:1744108]Non-hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1744108	J Biol Chem. 1991 Dec 5;266(34):23103-23111.	"Gibson BW, Tang DZ, Mandrell R, Kelly M, Spindel ER."	"Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis."
DRAMP01100	GIGGALLSAAKVGLKGLAKGLAEHFAN	27	"Bombinin-like peptide 1 (Contains: Bombinin H; toads, amphibians, animals)"	P29006	Belongs to the bombinin family	Not found	Bombina variegata (Yellow-bellied toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity, but low hemolytic activity. Preliminary evidence indicates that this peptide does not lyse and thus kill the bacteria by its antimicrobial activity. Bombinin H has antibacterial and hemolytic activity.
Tissue specificity: Expressed by the skin glands."	"[Ref.1712299]Gram-positive bacteria: Staphylococcus species;##Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Pseudomonas maltophilia, Alcaligenes denitrificans."	[Ref:8223491]Has low hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1712299##8223491	Eur J Biochem. 1991 Jul 1;199(1):217-222.##EMBO J. 1993 Dec;12(12):4829-4832.	"Simmaco M, Barra D, Chiarini F, Noviello L, Melchiorri P, Kreil G, Richter K.##Mignogna G, Simmaco M, Kreil G, Barra D."	A family of bombinin-related peptides from the skin of Bombina variegata.##Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.
DRAMP01140	GFVDLAKKVVGGIRNALGI	19	"Uperin-2.2 (toads, amphibians, animals)"	P82028	Not found	Not found	Uperoleia inundata (Floodplain toadlet)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows a weak antibacterial activity.
Tissue specificity: Expressed by the skin dorsal glands."	"Gram-positive bacteria: Bacillus cereus, Leuconostoc mesenteroides, L. innocua, Micrococcus luteus, Staphylococcus aureus and Streptococcus uberis.##Gram-negative bacteria: Pasteurella haemolytica, Escherichia coli."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Aust. J. Chem. 1996; 49:475-484.	"Bradford AM, Raftery MJ, Bowie JH, Tyler MJ, Wallace JC, Adams GW, Severini C."	Novel uperin peptides from the dorsal glands of the australian floodplain toadlet Uperoleia inundata.
DRAMP01171	GVVDILKGAGKDLLAHLVGKISEKV	25	"Ocellatin-1 (Frogs, amphibians, animals)"	P83951	Not found	Not found	Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has hemolytic activity against human erythrocytes and antibacterial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin dorsal glands."	[Swiss_Prot Entry P83951]Gram-negative bacterium: Escherichia coli	[Ref:15648972]Show hemolytic activity against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15648972	Protein J. 2004 Nov;23(8):501-508.	"Nascimento AC, Zanotta LC, Kyaw CM, Schwartz EN, Schwartz CA, Sebben A, Sousa MV, Fontes W, Castro MS."	Ocellatins: new antimicrobial peptides from the skin secretion of the South American frog Leptodactylus ocellatus (Anura: Leptodactylidae).
DRAMP01172	GVLDIFKDAAKQILAHAAEKQI	22	"Ocellatin-2 (Frogs, amphibians, animals)"	P83866	Not found	Not found	Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has hemolytic activity against human erythrocytes and antibacterial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin dorsal glands."	[Swiss_Prot Entry P83866]Gram-negative bacterium: Escherichia coli	[Ref:15648972]Show hemolytic activity against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15648972	Protein J. 2004 Nov;23(8):501-508.	"Nascimento AC, Zanotta LC, Kyaw CM, Schwartz EN, Schwartz CA, Sebben A, Sousa MV, Fontes W, Castro MS."	Ocellatins: new antimicrobial peptides from the skin secretion of the South American frog Leptodactylus ocellatus (Anura: Leptodactylidae).
DRAMP01173	GVLDILKNAAKNILAHAAEQI	21	"Ocellatin-3 (Frogs, amphibians, animals)"	P83867	Not found	Not found	Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has hemolytic activity against human erythrocytes and antibacterial activity against the Gram-negative bacterium E. coli.
Tissue specificity: Expressed by the skin dorsal glands.
PTM: C-terminal amidation."	[Swiss_Prot Entry P83867]Gram-negative bacterium: Escherichia coli	[Ref:15648972]Show hemolytic activity against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15648972	Protein J. 2004 Nov;23(8):501-508.	"Nascimento AC, Zanotta LC, Kyaw CM, Schwartz EN, Schwartz CA, Sebben A, Sousa MV, Fontes W, Castro MS."	Ocellatins: new antimicrobial peptides from the skin secretion of the South American frog Leptodactylus ocellatus (Anura: Leptodactylidae).
DRAMP01175	AVLDILKDVGKGLLSHFMEKV	21	"Ocellatin-5 (Frogs, amphibians, animals)"	P85443	Not found	Not found	Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has hemolytic and antibacterial activities.
Tissue specificity: Expressed by the skin dorsal glands."	[Ref.19739090]Gram-postive bacterium: Staphylococcus aureus(100% inhibition at 64¦Ìg/mL);##Gram-negative bacterium: Escherichia coli(100% inhibition at 32¦Ìg/mL).	[Ref:19739090]Show hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19739090##	"J Exp Zool A Ecol Genet Physiol. 2010 Jan 1;313(1):1-8.##Thesis (2007), University of Brasilia, Brazil"	"Leite JM Jr, Silva LP, Silva-Leite RR, Ferrari AS, Noronha SE, Silva HR, Bloch C Jr, Leite JR.##Nascimento A.C.C."	Leptodactylus ocellatus (Amphibia): mechanism of defense in the skin and molecular phylogenetic relationships.##Cytolytic peptides and proteases from the skin secretion of the frog Leptodactylus ocellatus).
DRAMP01196	KEKLKLKCKAPKCYNDKLACT	21	"Andersonin-G1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>200 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC>200 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>200 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC>200 ?g/ml)."	[Ref:22029824]Non-hemolytic activity against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01197	ENMFNIKSSVESDSFWG	17	"Andersonin-N1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>200 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC>200 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>200 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC>200 ?g/ml)."	[Ref:22029824]Non-hemolytic activity against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01198	EMLKKKKEVKMERKT	15	"Andersonin-Q1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Odorrana andersonii (Golden crossband frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions.	"[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>200 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC>200 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>200 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC>200 ?g/ml)."	[Ref:22029824]Non-hemolytic activity against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22029824	J Proteome Res. 2012 Jan 1;11(1):306-319.	"Yang X, Lee WH, Zhang Y."	Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
DRAMP01207	CYSAAKYPGFQEFINRKYKSSRF	23	"Galensin (Frogs, amphibians, animals)"	Q90W78	Not found	Not found	Kassina senegalensis (Senegal running frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against the Gram-positive bacteria: M. luteus and the Gram-negative bacteria E. coli. 
Tissue specificity: Expressed by the skin dorsal glands."	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Micrococcus luteus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases	"Reid C.N, Bjourson A.J, Shaw C."	"Galensin, a novel homodimeric antimicrobial peptide from the defensive skin secretion of Kassina senegalensis: isolation, structural characterisation and cloning of precursor cDNA."
DRAMP01212	SIITMTREAKLPQLWKQIACRLYNTC	26	"Pleurain-A3 (Pleurain A3; Frogs, amphibians, animals)"	A8B5P7	Not found	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Has little hemolytic activity on red blood cells.
Tissue specificity: Expressed by the skin dorsal glands."	"[Swiss_Prot Entry A8B5P7]has activity against Gram-positive and -negative bacteria, and fungi"	[Ref:17764786]Little hemolytic activity on red blood cells even with peptide concentration up to 200 ¦Ìg/ml	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17764786	Peptides. 2007 Oct;28(10):2069-2074.	"Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K."	A new family of antimicrobial peptides from skin secretions of Rana pleuraden.
DRAMP01213	SIITTTKEAKLPQLWKQIACRLYNTC	26	"Pleurain-A4 (Pleurain A4; Frogs, amphibians, animals)"	A8B5Q0	Not found	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Has little hemolytic activity on red blood cells.
Tissue specificity: Expressed by the skin dorsal glands."	"[Swiss_Prot Entry A8B5Q0]has activity against Gram-positive and -negative bacteria, and fungi"	[Ref:17764786]Little hemolytic activity on red blood cells even with peptide concentration up to 200 ¦Ìg/ml	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17764786	Peptides. 2007 Oct;28(10):2069-2074.	"Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K."	A new family of antimicrobial peptides from skin secretions of Rana pleuraden.
DRAMP01223	GFMDTAKQVAKNVAVTLIDKLRCKVTGGC	29	"Palustrin-2AJ2 (PL2AJ12; Frogs, amphibians, animals)"	G3F828	Not found	Not found	Amolops jingdongensis (Chinese torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Has low hemolytic activity, low cytotoxicity and low antioxidant activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 23-29 and Cleavage on pair of basic residues."	[Swiss_Prot Entry G3F828]broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria	[Ref:21816202]Show slight hemolytic activity against human and rabbit erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21816202	Biochimie. 2012 Feb;94(2):328-334.	"Chen Z, Yang X, Liu Z, Zeng L, Lee W, Zhang Y."	"Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis."
DRAMP01226	ALFSILRGLKKLGKMGQAFVNCEIYKKC	28	"Palustrin-1a (Frogs, amphibians, animals)"	P84274	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP01230	GFLSTVKNLATNVAGTVLDTIRCKVTGGCRP	31	"Palustrin-2a (Frogs, amphibians, animals)"	P84278	Not found	Not found	Rana palustris (Pickerel frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Tissue specificity: Expressed by the skin glands.	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11087945	Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.	"Basir YJ, Knoop FC, Dulka J, Conlon JM."	"Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris."
DRAMP18404	INWLKLGKMVIDAL	14	"Polybia-MPII (mastoparan; insects, arthropods, invertebrates, animals)"	No entry found	Not found	Not found	"venom, the social wasp, Pseudopolybia vespiceps testacea"	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"		Not found	Not found	None	Fuction: It demonstrated a potent ability to suppress endotoxin lipopolysaccharide (LPS)-mediated induction of the pro-inflammatory cytokine TNF-a in human peripheral blood mononuclear cells by 94%. It also completely protected mice against an invasive S. aureus infection when given I.P. to mice at 8 mg/kg 4 hr prior to initiation of the infection. Surface immobilization led to enhanced antimicrobial activity against P. aeruginosa.	Gram-positive bacteria: S. aureus(MIC 2.3 ug/ml);##Gram-negative bacteria: P. aeruginosa (MIC 9 ug/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28108242	Int J Antimicrob Agents. 2017 Feb;49(2):167-175. 2017	"Silva JC, Neto LM, Neves RC, Gon?alves JC, Trentini MM, Mucury-Filho R, Smidt KS, Fensterseifer IC, Silva ON, Lima LD, Clissa PB, Vilela N, Guilhelmelli F, Silva LP, Rangel M, Kipnis A, Silva-Pereira I, Franco OL, Junqueira-Kipnis AP, Bocca AL, Mortari MR."	"Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera)"
DRAMP18402	GKGSWSKKIEVIA	13	"Tridecaptin B1 (TriB1; lipopeptides; nonribosomally synthesized peptide antibiotic, Gram-positive"	No entry found	Not found	Not found	Paenibacillus polymyxa NRRL B-30507	"Antimicrobial, Antibacterial, Anti-Gram-"		Not found	Not found	None	Comment: No comments found on DRAMP database	Active against multidrug resistant Gram-negative bacteria.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	25959079	Org Biomol Chem. 2015 Jun 7;13(21):6073-81. doi: 10.1039/c5ob00780a.	"Cochrane SA, Lohans CT, van Belkum MJ, Bels MA, Vederas JC."	"Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria"
DRAMP01338	FLPMLAGLAANFLPKLFCKITKKC	24	"Amolopin-1a (Frogs, amphibians, animals)"	"A0SN41, A0SN38, A0SN39"	Not found	Not found	Amolops loloensis (Rufous-spotted torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Staphylococcus aureus, Bacillus dysenteriae;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17000029	Peptides. 2006 Dec;27(12):3085-3091. 	"Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R."	"Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis."
DRAMP01342	FLPIVGKLLSGLL	13	"Amolopin-2b (Frogs, amphibians, animals)"	"A0SN47, A0SN48"	Not found	Not found	Amolops loloensis (Rufous-spotted torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Staphylococcus aureus, Bacillus dysenteriae;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17000029	Peptides. 2006 Dec;27(12):3085-3091. 	"Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R."	"Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis."
DRAMP01343	FLPMLAGLAANLLPKLFCKITKKC	24	"Amolopin-1c (Frogs, amphibians, animals)"	A0SN43	Not found	Not found	Amolops loloensis (Rufous-spotted torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Staphylococcus aureus, Bacillus dysenteriae;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17000029	Peptides. 2006 Dec;27(12):3085-3091. 	"Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R."	"Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis."
DRAMP01344	LLPIVGKLLSGLL	13	"Amolopin-2c (Frogs, amphibians, animals)"	A0SN50	Not found	Not found	Amolops loloensis (Rufous-spotted torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Staphylococcus aureus, Bacillus dysenteriae;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17000029	Peptides 2006; 27: 3085-3091.	Lu Y et al Lai R2006	"Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis"
DRAMP01345	FLPMLAGLAANFLPELFCKITKKC	24	"Amolopin-1d (Frogs, amphibians, animals)"	A0SN44	Not found	Not found	Amolops loloensis (Rufous-spotted torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.	"Gram-positive bacteria: Staphylococcus aureus, Bacillus dysenteriae;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17000029	Peptides. 2006 Dec;27(12):3085-3091. 	"Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R."	"Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis."
DRAMP01444	GLLDSIKGMAISAGKGALQNLLKVASCKLDKTC	33	"Nigrocin-1 (Frogs, amphibians, animals)"	P0C008	Not found	Not found	Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata) (frog skin active peptide)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has weak hemolytic activity.
Tissue specificity: Expressed by the skin dorsal glands.
PTM: Contains one disulfide bond 27-33. (By similarity)"	"[Ref.11682065]Gram-positive bacterium: Micrococcus luteus(MIC=2.5¦Ìg/ml);##Gram-negative bacteria: Shigella dysenteriae(MIC=10¦Ìg/ml), Klebsiella pneumoniae(MIC=10¦Ìg/ml), Pseudomonas aeruginosa(MIC=75¦Ìg/ml), Salmonella typhimurium(MIC=22.5¦Ìg/ml), Proteus mirabilis(MIC>200¦Ìg/ml), Serratia marcescens(MIC>200¦Ìg/ml);##Yeast: Candida albicans(MIC=100¦Ìg/ml)."	[Ref:11682065]1.1% hemolytic activity at 100¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11682065	FEBS Lett. 2001 Oct 19;507(1):95-100.	"Park S, Park SH, Ahn HC, Kim S, Kim SS, Lee BJ, Lee BJ."	"Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata."
DRAMP01445	GLLSKVLGVGKKVLCGVSGLC	21	"Nigrocin-2 (Nigrocin-2LVa; Frogs, amphibians, animals)"	P0C009	Not found	Not found	Rana nigromaculata (Black-spotted frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: Thanks to its single linear amphipathic alpha-helix, may integrate into membrane phospholipids, leading to lysis of the membrane. Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has weak hemolytic activity.
Tissue specificity: Expressed by the skin dorsal glands.
PTM: Contains one disulfide bond 15-21. (By similarity)"	"[Ref.11682065]Gram-positive bacterium: Micrococcus luteus(MIC=2.5¦Ìg/ml);##Gram-negative bacteria: Shigella dysenteriae(MIC=10¦Ìg/ml), Klebsiella pneumoniae(MIC=10¦Ìg/ml), Pseudomonas aeruginosa(MIC=100¦Ìg/ml), Salmonella typhimurium(MIC=22.5¦Ìg/ml), Proteus mirabilis(MIC>200¦Ìg/ml), Serratia marcescens(MIC>200¦Ìg/ml);##Yeast: Candida albicans(MIC=150¦Ìg/ml)."	[Ref:11682065] It has 0.9% hemolytic activity at 100¦Ìg/ml against human red blood cells	Cyclic	Free	Cyclization (Cys15 and Cys21)	Disulfide bond between Cys15 and Cys21.	L	No cytotoxicity information found	Cell membrane	11682065	FEBS Lett. 2001 Oct 19;507(1):95-100.	"Park S, Park SH, Ahn HC, Kim S, Kim SS, Lee BJ, Lee BJ."	"Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata."
DRAMP01446	VIEPKCYKYEGKKCPPDINPVCGTDKRTYYNECALCVFIRQSTKKADKAIKIKKWGKC	58	"Proteinase inhibitor PSKP-1 (Frogs, amphibians, animals)"	P83578	Not found	Not found	Phyllomedusa sauvagei (Sauvage's leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows hemagglutinating activity, inhibits prolyl endopeptidase. May have a role in mucosal defense against microbes by interacting directly with their membranes."	Gram-negative bacterium: Escherichia coli (EC50=3 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15153102	Eur J Biochem. 2004 Jun;271(11):2117-2126.	"Gebhard L.G, Carrizo F.U, Stern A.L, Burgardt N.I, Faivovich J, Lavilla E, Ermacora M.R."	A Kazal prolyl endopeptidase inhibitor isolated from the skin of Phyllomedusa sauvagii.
DRAMP01463	GLFSKFNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC	46	"Esculentin-1SEa (Frogs, amphibians, animals)"	P85059	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sevosa (Dusky gopher frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity.
Tissue specificity: Expressed by the skin glands. 
PTM: Problely contains one dislfide bond 40-46."	Gram-negative bacterium: Escherichia coli K12;##Gram-positive bacterium: Micrococcus luteus NCT C2665.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16386333	Peptides. 2006 Jun;27(6):1313-1319.	"Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C."	"Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa."
DRAMP01464	GLFSKFNKKKIKSGLFKIIKTAGKEAGLEALRTGIDVIGCKIKGEC	46	"Esculentin-1SEb (Frogs, amphibians, animals)"	P85054	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sevosa (Dusky gopher frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity.
Tissue specificity: Expressed by the skin glands. 
PTM: Problely contains one dislfide bond 40-46."	Gram-negative bacterium: Escherichia coli K12;##Gram-positive bacterium: Micrococcus luteus NCT C2665.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16386333	Peptides. 2006 Jun;27(6):1313-1319.	"Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C."	"Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa."
DRAMP01465	GIFSKLAGKKLKNLLISGLKSVGKEVGMDVVRTGIDIAGCKIKGEC	46	"Esculentin-1R (Frogs, amphibians, animals)"	P86018	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana ridibunda (Laughing frog) (Marsh frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 40-46."	[Swiss_Prot Entry P86018]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref:18855342]Low hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18855342	Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.	"Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT."	De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.
DRAMP01489	GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC	46	"Esculentin-1A (Frogs, amphibians, animals)"	P40843	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (European Edible frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 40-46."	[Swiss_Prot Entry P40843]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref:8163497]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01492	GIFSLVKGAAKLAGKGLAKEGGKFGLELIACKIAKQC	37	"Esculentin-IIb (Frogs, amphibians, animals)"	P40846	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (European Edible frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species.	[Swiss_Prot Entry P40846]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref:8163497]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP18312	MTDANVDARRARAPHGISGAIAGVVAGCAATIEIGCVEGAIAGIGPSGIASMIAALWTCRSKYRRFSSGSGYVMLLSWSAEFVFGYFIGCRCGFLLSQK	99	Propionicin PLG-1(Bacteriocin)	I2HA02	Not found	plg-1	Propionibacterium thoeniiP127	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"		Not found	Not found	None	"Propionicin PLG-1 is active against a variety of microorganisms such as propionibacteria, as well as many other gram-positive and gram-negative bacteria and even fungi.Propionicin PLG-1 is stable after long-term storage in a dry or frozen state and rapidly kills sensitive cells upon exposure in culture medium or skim milk."	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11010864	Appl Environ Microbiol. 2000 Oct;66(10):4230-6.	"Faye T, Langsrud T, Nes IF, Holo H."	"Biochemical and genetic characterization of propionicin T1, a new bacteriocin from Propionibacterium thoenii."
DRAMP01744	FLPLIGKVLSGIL	13	"Temporin-G (Frogs, amphibians, animals)"	P79875 	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against Gram-negative and Gram-positive bacteria.
PTM: Leucine amide at position 13.
Tissue specificity: Expressed by the skin glands."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9022710	Eur J Biochem. 1996 Dec 15;242(3):788-792.	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D."	"Temporins, antimicrobial peptides from the European red frog Rana temporaria."
DRAMP01743	FLPLIGKVLSGIL	13	"Temporin-F (Frogs, amphibians, animals)"	P56921	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against Gram-negative and Gram-positive  bacteria.
PTM: Leucine amide at position 13.
Tissue specificity: Expressed by the skin glands."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9022710	Eur J Biochem. 1996 Dec 15;242(3):788-792.	"Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D."	"Temporins, antimicrobial peptides from the European red frog Rana temporaria."
DRAMP01519	GVFSFLKTGAKLLGSTLLKMAGKAGAEHLACKATNQC	37	"Esculentin-2PRa (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pretiosa (North American oregon spotted frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. 	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus.##Yeast: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	21295070	Dev Comp Immunol. 2011 Jun;35(6):644-649.	"Conlon JM, Mechkarska M, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, Hayes MP, Padgett-Flohr G."	Host defense peptides in skin secretions of the Oregon spotted frog Ranapretiosa: implications for species resistance to chytridiomycosis.
DRAMP01671	ALWMTLLKKVLKAAAKALNAVLVGANA	27	"Dermaseptin-4 (DS IV; Dermaseptin-S4, DS4; Frogs, amphibians, animals)"	P80280	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	Not found	Phyllomedusa sauvagei (Sauvage's leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Protein level	Combine strand and Turn structure	Not found	None	"Function: Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1. Probably acts by disturbing membrane functions with its amphipathic structure. Has strong hemolytic activity. Does not bind to P. falciparum infected erythrocytes, but accumulates within the parasite.
Tissue specificity: Expressed by the skin glands.
Pharmaceutical use: Derivatives of this peptide may be used as therapeutic agents to treat bacterial infections and malaria, and to prevent infection by herpes simplex virus type 1 and HIV-1."	"[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1"	[Ref:11850249]IC50=20 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	healthy erythrocytes (this binding is receptor independent).	8306981##11850249##9395500	Eur J Biochem. 1994 Jan 15;219(1-2):145-154.##Antimicrob Agents Chemother. 2002 Mar;46(3):689-694.##J Biol Chem. 1997 Dec 12;272(50):31609-31616.	"Mor A, Nicolas P.##Navon-Venezia S, Feder R, Gaidukov L, Carmeli Y, Mor A.##Ghosh JK, Shaool D, Guillaud P, Cic??ron L, Mazier D, Kustanovich I, Shai Y, Mor A."	Isolation and structure of novel defensive peptides from frog skin.##Antibacterial properties of dermaseptin S4 derivatives with in vivo activity.##Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis.
DRAMP01697	GMWSKIKNAGKAAKAAAKAAGKAALGAVSEAM	32	"Dermaseptin-DA4 (DRS-DA4; Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	Not found	Pachymedusa dacnicolor (Mexican frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	It shows selective activity against gram-negative bacteria and not toxic to fresh rat erythrocytes. DRS-DA4 is a potent chemoattractant for human leukocytes and is devoid of hemolytic activity.	"[Ref.FEBS J. 2009 Nov;276(22):6773-6786.]Gram-negative bacteria:Escherichia coli ML35p(MIC=5 ?M), Escherichia coli 363 ATCC 11775(MIC=5 ?M), Peudomonas aeruginosa ATCC 27853(MIC=40 ?M)."	[Ref. FEBS J. 2009 Nov;276(22):6773-6786.]Show no hemolytic activity against rat blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	FEBS J. 2009 Nov;276(22):6773-6786.	"Auvynet C, Joanne P, Bourdais J, Nicolas P, Lacombe C, Rosenstein Y."	"Dermaseptin DA4, although closely related to dermaseptin B2, presents chemotactic and Gram-negative selective bactericidal activities."
DRAMP01700	GLWSTIKNVAAAAGKAALGAL	21	"Dermaseptin-H3 (Dermaseptin-like peptide 3, DMS3; Frogs, amphibians, animals)"	Q17UY8	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	dpp-H3	Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	MOA: Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).	"Gram-negative bacterium: Escherichia coli;##Gram-positive bacteria: Staphylococcus aureus, Micrococcus luteus."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17553595	Peptides. 2007 Jul;28(7):1331-43.	"Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S."	A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.
DRAMP01717	SLGSFLKGVGTTLASVGKVVSDQFGKLLQAGQ	32	"Dermatoxin (Frogs, amphibians, animals)"	"Q9PT75, P81566"	Belongs to the frog skin active peptide family (Dermaseptin subfamily)	DRT	Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Possesses a potent antimicrobial activity against Gram-positive bacteria and less active against Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.
Tissue specificity: Highest expression in skin and to a lesser extent in brain and intestine.
Miscellaneous: The sequence shown corresponds to the dermatoxin isolated from frog skin. A variant of it is present in frog brain."	"Gram-positive bacteria: Bacillus megaterium, Corynebacterium glutamicumm, Staphylococcus aureus (++);##Gram-negative bacteria: mollicutes Acholeplasma laidlawii, Spiroplasma melliferum (++); Burkholderia cepacia, Pseudomonas aeruginosa, Salmonella typhimurium and S. meliloti (+)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10880984	Eur J Biochem. 2000 Jul;267(14):4583-4592.	"Amiche M, Seon AA, Wroblewski H, Nicolas P."	"Isolation of dermatoxin from frog skin, an antibacterial peptide encoded by a novel member of the dermaseptin genes family."
DRAMP02857	ILPWKWPWWPWRR	13	"Indolicidin (Cathelicidin-4; mammals, animals)"	"P33046, A3KN14"	Belongs to the cathelicidin family	CATHL4	Bos taurus (Bovine) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	No secondary structure	"The backbone structure in DPC, well defined between residues 3 and 11, is extended, with two half-turns at residues Lys-5 and Trp-8. The backbone structure in SDS, well defined between residues 5 and 11, is also extended, but lackes the bend in the C-terminal half. Indolicidin in complexes with DPC has a central hydrophobic core composed of proline and tryptophan, which is bracketed by positively charged regions near the peptide termini"	"1G8C, 1G89 resolved by NMR."	"Function: Potent microbicidal activity; active against Staphylococcus aureus, Escherichia coli and Candida albicans.
Tissue specificity: Large granules of neutrophils.
PTM: Contains two disulfide bonds and C-terminal amidation."	[Ref.12074933] Gram-positive bacterium: Staphylococcus aureus (MIC=0.003%);##Gram-negative bacterium: Escherichia coli (MIC=0.007%);##Fungus: Candida albicans (MIC=0.015%)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1537821##11123901##12074933	J Biol Chem. 1992 Mar 5;267(7):4292-4295.##Biochemistry. 2000 Dec 26;39(51):15765-74.##Life Sci. 2002 Jul 5;71(7):747-50.	"Selsted ME, Novotny MJ, Morris WL, Tang YQ, Smith W, Cullor JS.##Rozek A, Friedrich CL, Hancock RE.##Kowalska K, Carr DB, Lipkowski AW."	"Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils.##Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.##Direct antimicrobial properties of substance P."
DRAMP02819	GLLKRIKTLL	10	"Anoplin (Insects, arthropods, invertebrates, animals)"	P0C005	Not found	Not found	Anoplius samariensis (Solitary wasp)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	The peptide adopts a random coil structure in water and tends to fold into an 	"2MJQ,2MJR,2MJS,2MJT"	"[Ref.29614317]Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.##[Ref.25316570]Function: Exhibits potent activity in stimulating degranulation from rat peritoneal mast cells but not from RBL-2H3 cells. Exhibits broad-spectrum antimicrobial activity against both Gram-negative bacteriapositive and Gram-negative bacterianegative bacteria. Has no hemolytic activity towards human erythrocytes."	"[Ref.29614317]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=26 ¦Ìg/mL);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=13 ¦Ìg/mL);##Fungi: Candida albicans ATCC 10231 (MIC=19.5 ¦Ìg/mL).##[Ref.25316570]Gram-positive bacteria : Staphylococcus aureus (MIC=64 ¦Ìg/ml), bacillus subtilis (MIC=32 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli (MIC=64 ¦Ìg/ml), Peudomonas eruginosa (MIC=32 ¦Ìg/ml).##[Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=200 ¦Ìg/ml), Bacillus subtilis DELTA (MIC=300 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli DH5a (MIC=200 ¦Ìg/ml), Pseudomonas aeruginosa PAO (MIC=100 ¦Ìg/ml), Zymomonas mobilis 10988 (MIC=40 ¦Ìg/ml);##Fungi : Candida parapsilosis (MIC=15 ¦Ìg/ml)"	"[Ref.25316570] 1% hemolysis at 12.5 ¦Ìg/ml , 2% hemolysis at 25 ¦Ìg/ml , 1% hemolysis at 50 ¦Ìg/ml , 1.5% hemolysis at 100 ¦Ìg/ml , 1.5% hemolysis at 200 ¦Ìg/ml against mice red blood cells.##[Ref.27862650]3% hemolysis at  100¦Ìg/ml , 6% hemolysis at 200¦Ìg/ml , 10% hemolysis at 300¦Ìg/ml , 12% hemolysis at 500¦Ìg/ml against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29614317##25316570#27862650	Peptides. 2018 Jun;104:7-14.##J Pept Sci.?2014 Dec;20(12):945-51. doi: 10.1002/psc.2705.##J Pept Sci.?2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.	"Salas RL, Garcia JKDL, Miranda ACR, Rivera WL, Nellas RB, Sabido PMG.##Yang Wang, Jianbo Chen, Xin Zheng, Xiaoli Yang, Panpan Ma,Ying Cai,Bangzhi Zhangb,and Yuan Chen##Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis"	Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin.##Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity##Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin
DRAMP04395	AMVGT	5	"EP3 (Earthworm,animals)"	No entry found	Belongs to the antibacterial vermipeptides family (AVPF)	Not found	Eisenia foetida (Common brandling worm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-negative and Gram-positive bacteria.	"[Ref.European Journal of Soil Biology, 2007, 43 S127-S134] Gram-negative bacteria: Pseudomonas pyocyanea (IC=12.58 ¦Ìg/ml), Acinetobacter baumanii (IC=12.58 ¦Ìg/ml), Klebsiella terrigena (IC=12.58 ¦Ìg/ml);## Gram-positive bacteria: Enterococcus gallinarum (IC=12.58 ¦Ìg/ml), Enterococcus faecalis (IC=25.68 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	"European Journal of Soil Biology, 2007, 43:S127-S134"	"C Wang, Z Suna, X Zhang, G Xu## Ito Y, Yoshikawa A, Hotani T, Fukuda S, Sugimura K, Imoto T."	A novel antimicrobial vermipeptide family from earthworm Eisenia fetida.
DRAMP04394	AMVSS	5	"EP2 (Earthworm,animals)"	No entry found	Belongs to the antibacterial vermipeptides family (AVPF)	Not found	Eisenia foetida (Common brandling worm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-negative and Gram-positive bacteria.	"[Ref.European Journal of Soil Biology, 2007, 43 S127-S134] Gram-negative bacteria: Pseudomonas pyocyanea (IC=11.4 ¦Ìg/ml), Acinetobacter baumanii (IC=11.4 ¦Ìg/ml), Klebsiella terrigena (IC=11.4 ¦Ìg/ml);##Gram-positive bacteria: Enterococcus gallinarum (IC=11.4 ¦Ìg/ml), Enterococcus faecalis (IC=22.8 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	"European Journal of Soil Biology, 2007, 43:S127-S134."	"C Wang, Z Suna, X Zhang, G Xu## Ito Y, Yoshikawa A, Hotani T, Fukuda S, Sugimura K, Imoto T."	A novel antimicrobial vermipeptide family from earthworm Eisenia fetida.
DRAMP02396	ACSAG	5	"OEP3121 (EP5-1;earthworm,animals)"	P84182	Not found	Not found	Eisenia foetida (Common brandling worm) (Common dung-worm)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Protein level	Not found	Not found	None	Function: Displays antimicrobial activity. The effects of EP5 on HeLa cells lead to the cancer cell's apoptosis and break down. 	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15253156##PubMed ID is not available	"Acta Biochim Biophys Sin (Shanghai). 2004 Apr;36(4):297-302.##European Journal of Soil Biology, 2007, 43:S127-S134."	"Liu YQ, Sun ZJ, Wang C, Li SJ, Liu YZ.##C Wang, Z Suna, X Zhang, G Xu."	Purification of a novel antibacterial short peptide in earthworm Eisenia foetida.##A novel antimicrobial vermipeptide family from earthworm Eisenia fetida.
DRAMP02242	GLMDVFKGAAKNLLASALDKIRCKVTKC	28	"Ranatuerin-2PRa (frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pirica (Hokkaido frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: activity against reference strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae) and Gram-positive (Staphlococcus aureus) bacteria but displayed relatively low hemolytic activity. "	[Ref.15003829] Gram-negative bacterium: Escherichia coli(MIC=13¦ÌM);## Gram-positive bacterium: Staphylococcus aureus(MIC>100¦ÌM);## Yeast: Candida albicans(MIC=100¦ÌM)	[Ref.15003829] HC50=150¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys23 and Cys28)	Disulfide bond between Cys23 and Cys28.	L	No cytotoxicity information found	Not found	15003829	Regul Pept. 2004 May 15;118(3):135-141.	"Conlon JM, Sonnevend A, Patel M, Al-Dhaheri K, Nielsen PF, Kolodziejek J, Nowotny N, Iwamuro S, P"	"A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica."
DRAMP01772	FLPLIGKILGTILGK	15	"Temporin-1Ob (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana ornativentris (Japanese mountain brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17147973	Peptides. 2007 Mar;28(3):524-532.	"Ohnuma A, Conlon JM, Yamaguchi K, Kawasaki H, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S."	Antimicrobial peptides from the skin of the Japanese mountain brown frog Rana ornativentris: evidence for polymorphism among preprotemporin mRNAs.
DRAMP01799	ILPILGNLLNGLL	13	"Temporin-1PRa (Temporin 1PRa; Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pirica (Hokkaido frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: It shows only very weak antimicrobial and hemolytic activity.	[Ref.15003829]Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria:Escherichia coli (MIC>100 ?M);##Fungi:Candida albicans (MIC>100 ?M)	[Ref:15003829]HC50>300 ¦ÌM against washed human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15003829	Regul. Pept 2004; 118: 135-141.	Conlon JM et al Pal T.	"A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica."
DRAMP01800	ILPILGNLLNSLL	13	"Temporin-1PRb (Temporin 1PRb; Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pirica (Hokkaido frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus.##Yeast: Candida albicans (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15003829	Regul. Pept 2004; 118: 135-141.	Conlon JM et al Pal T.	"A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica."
DRAMP01801	FIGPIISALASLFG	14	"Temporin-1DYa (Frogs, amphibians, animals)"	P0C5X6	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Active against the Gram-positive bacteria: S. aureus and Gram-negative bacteria E.coli. Tissue specificity: Expressed by the skin glands. PTM: Glycine amide at position 14.	Gram-positive bacterium: Staphylococcus aureus (MIC>60 ?M);##Gram-negative bacterium: Escherichia coli (MIC>60 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17688900	Toxicon. 2007 Nov;50(6):746-756.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S."	"Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii."
DRAMP01802	FFGSVLKLIPKIL	13	"Temporin-PTa (Frogs, amphibians, animals)"	P0C8U2	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana picturata (Malaysian fire frog) (Hylarana picturata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix	Not found	None	Function: Has antibacterial activity against the Gram-positive bacteria: S. aureus ATCC 25923 and the Gram-negative bacteria E.coli ATCC 25726. Tissue specificity: Expressed by the skin glands. PTM: Leucine amide at position 13.	Gram-positive bacterium: Staphylococcus aureus ATCC 25923;##Gram-negative bacterium: Escherichia coli ATCC 25726	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01804	ILPILAPLIGGLL	13	"Temporin-CDYb (Brevinin-1CDYb; Frogs, amphibians, animals)"	B3VZU4	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Has low activity against the Gram-positive bacteria: S. aureus and Gram-negative bacteria E.coli. Has weak hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: Leucine amide at position 13.	[Swiss_Prot Entry B3VZU4]Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M).	[Ref:19539775]HC50=180 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19539775	Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178. 	"Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH."	"Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii."
DRAMP01387	GLLSGILGAGKHIVCGLSGPCQSLNRKSSDVEYHLAKC	38	"Odorranain-P2a (OdP2a; Frogs, amphibians, animals)"	A6MBR1	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Odorranain-P2a exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=6.25 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.12 ¦Ìg/ml), Bacillus subtilis (MIC=12.5 ¦Ìg/ml).##Yeast: Candida albicans (MIC=3.12 ¦Ìg/ml)."	[Ref:17272268]Non-hemolytic activity against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP04210	GIGKHVGKALKGLKGLLKGLGES	24	Adepantin-1 (Automatically Designed Peptide antibacterial 1; synthetic)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Helix	Not found	None	Function: Antibacterial activity against Gram negative bacteria. Has hemolytic activity.	"[Ref.19947578] Gram-negative bacteria: Escherichia coli ATCC (MIC=2-4 ¦ÌM), Pseudomonas aeruginosa (MIC=16 ¦ÌM)."	[Ref.19947578] HC50>800 ¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membranes	19947578	J Chem Inf Model. 2009 Dec;49(12):2873-82	"Jureti? D, Vukicevi? D, Ili? N, Antcheva N, Tossi A."	Computational design of highly selective antimicrobial peptides.
DRAMP01824	ILPLVGNLLNDLL	13	"Temporin-1Ja (Frogs, amphibians, animals)"	P83307	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana japonica (Japanese reddish frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria E. coli and the Gram-positive bacteria: S. aureus. Tissue specificity: Expressed by the skin glands. PTM: Leucine amide at position 13. 	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11835990	Peptides. 2002 Mar;23(3):419-425.	"Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM."	Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.
DRAMP01826	RIGVLLARLPKLFSLFKLMGKKV	23	"RV-23 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana aurora draytonii (California red-legged frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Alpha helix	Not found	None	[Ref.27271216]Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=12.5 ¦ÌM), Staphylococcus epidermidis (MIC=3.13 ¦ÌM), Bacillus subtilis (MIC=3.13 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa (MIC=6.25 ¦ÌM), Klebsiella pneumoniae (MIC=6.25 ¦ÌM)"	"[Ref.27271216] 60% hemolysis at 20 ¦ÌM , 90% hemolysis at 40 ¦ÌM , 100% hemolysis at 60 ¦ÌM , 100% hemolysis at 100 ¦ÌM against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16307827##27271216	Peptides. 2006 Jun;27(6):1305-1312.##Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Conlon JM, Al-Ghafari N, Coquet L, Leprince J, Jouenne T, Vaudry H, Davidson C.##Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	"Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species.##Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity"
DRAMP01126	ILGPVISKIGGVLGGLLKNL	20	"Maximin-H4 (Toads, amphibians, animals)"	"P83084, Q58T61, Q58T60"	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Shows strong hemolytic activity. "	"[Ref.11835991] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=12 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=6 ¦Ìg/ml), Bacillus pyocyaneus CMCCB 1010 (MIC=12 ¦Ìg/ml).##Yeast: Candida albicans ATCC 2002 (MIC=6 ¦Ìg/ml)."	[Ref:11835991]90¨C100% hemolytic activity at 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP01125	ILGPVLGLVGNALGGLIKKI	20	"Maximin-H3 (Toads, amphibians, animals)"	"P83083, Q58T42, Q58T44, Q58T45, Q58T52, Q58T55, Q58T62, Q58T68, Q58T70"	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Shows strong hemolytic activity."	"[Ref.11835991] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=20 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=10 ¦Ìg/ml), Bacillus pyocyaneus CMCCB 1010 (MIC=20 ¦Ìg/ml);##Fungi: Candida albicans ATCC 2002 (MIC=5 ¦Ìg/ml)."	[Ref:11835991]90¨C100% hemolytic activity at 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP01841	GFRDVLKGAAKQFVKTVAGHIANI	24	"Ascaphin-2 (Frogs, amphibians, animals)"	P0CJ26	Belongs to the ascaphin family	Not found	Ascaphus truei (Coastal tailed frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands.	[Ref.15207717]Gram-negative bacterium: Escherichia coli	[Ref.15207717]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15207717	Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.	"Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF."	"The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei."
DRAMP01843	GFKDWIKGAAKKLIKTVAANIANQ	24	"Ascaphin-4 (Frogs, amphibians, animals)"	P0CJ28	Belongs to the ascaphin family	Not found	Ascaphus truei (Coastal tailed frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands.	[Ref.15207717]Gram-negative bacterium: Escherichia coli	[Ref.15207717]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15207717	Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.	"Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF."	"The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei."
DRAMP01845	GFKDWIKGAAKKLIKTVASSIANE	24	"Ascaphin-6 (Frogs, amphibians, animals)"	P0CJ30	Belongs to the ascaphin family	Not found	Ascaphus truei (Coastal tailed frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. 
Caution: May represent an artifactually modified form of ascaphin-7 arising from hydrolysis during the purification procedure."	[Ref.15207717]Gram-negative bacterium: Escherichia coli	[Ref.15207717]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15207717	Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175.	"Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF."	"The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei."
DRAMP01901	GILDKLKEFGISAARGVAQSLLNTASCKLAKTC	33	"Brevinin-2CG1 (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Amolops chunganensis	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Primarily active against Gram-positive bacteria. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea.	"Gram-negative bacteria: P. faecalis X29, S. rubidaea."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22951323	Peptides. 2012 Nov;38(1):41-53.	"Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H."	Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis.
DRAMP01924	FLPAIFRMAAKVVPTIICSITKKC	24	"Brevinin-1Ea (Frogs, amphibians, animals)"	P40835	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (European frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity."	[Swiss_Prot Entry P40835]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.8163497]LC50=0.5 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01925	VIPFVASVAAEMQHVYCAASRKC	23	"Brevinin-1Eb (Frogs, amphibians, animals)"	P40836	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (European frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity."	[Swiss_Prot Entry P40836]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.8163497]LC50=0.5 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01926	FLPLLAGLAANFFPKIFCKITRKC	24	"Brevinin-1Ec (Frogs, amphibians, animals)"	P86150	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana ridibunda (Laughing frog) (Marsh frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity."	[Swiss_Prot Entry P86150]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.18855342]show hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18855342	Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.	"Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT."	De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.
DRAMP01927	GILDTLKNLAISAAKGAAQGLVNKASCKLSGQC	33	"Brevinin-2Ea (Frogs, amphibians, animals)"	P40837	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity "	[Swiss_Prot Entry P40837]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.8163497]LC50>100 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01928	GILDTLKNLAKTAGKGALQGLVKMASCKLSGQC	33	"Brevinin-2Eb (Frogs, amphibians, animals)"	P40838	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity "	[Swiss_Prot Entry P40838]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.8163497]LC50>100 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01929	GILLDKLKNFAKTAGKGVLQSLLNTASCKLSGQC	34	"Brevinin-2Ec (Frogs, amphibians, animals)"	"P40839, P84842"	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus) (Rana saharica (Sahara frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity "	[Swiss_Prot Entry P40839]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.8163497]LC50>100 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497##16394170	J Biol Chem. 1994 Apr 22;269(16):11956-11961.##J Endocrinol. 2006 Jan;188(1):1-9.	"Simmaco M, Mignogna G, Barra D, Bossa F.##Marenah L, Flatt PR, Orr DF, Shaw C, Abdel-Wahab YH."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.##Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity.
DRAMP01931	GILDSLKNLAKNAGQILLNKASCKLSGQC	29	"Brevinin-2Ed (Frogs, amphibians, animals)"	P40840	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity "	[Swiss_Prot Entry P40840]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.8163497]LC50>100 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01932	GIFDKLKNFAKGVAQSLLNKASCKLSGQC	29	"Brevinin-2Ee (Frogs, amphibians, animals)"	P40841	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity "	[Swiss_Prot Entry P40841]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.8163497]LC50>100 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8163497	J Biol Chem. 1994 Apr 22;269(16):11956-11961.	"Simmaco M, Mignogna G, Barra D, Bossa F."	Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP01936	GLWNTKLEAGLLFAMGKLDLKRCLKAGGC	29	"Brevinin-2Ek (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta complex	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli (By similarity).
Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14499272	Peptides. 2003 Jul;24(7):955-961.	"Ali MF, Knoop FC, Vaudry H, Conlon JM."	Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex.
DRAMP01945	FLPLVRGAAKLIPSVVCAISKRC	23	"Brevinin-1SE (Frogs, amphibians, animals)"	P85056	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sevosa (Dusky gopher frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro.	Gram-negative bacterium: Escherichia coli K12;##Gram-positive bacterium: Micrococcus luteus NCT C2665.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16386333	Peptides. 2006 Jun;27(6):1313-1319.	"Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C."	"Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa."
DRAMP01946	GLFNVFKGLKTAGKHVAGSLLNQLKCKVSGGC	32	"Brevinin-20a (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana Ornativentris (Japanese mountain brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11892844	J Pept Res. 2001 Nov;58(5):349-356.	Kim JB et al Conlon JM.	"Antimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris."
DRAMP01947	GIFNVFKGALKTAGKHVAGSLLNQLKCKVSGEC	33	"Brevinin-20b (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana Ornativentris (Japanese mountain brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11892844	J Pept Res. 2001 Nov;58(5):349-356.	Kim JB et al Conlon JM.	"Antimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris."
DRAMP18294	ALQFIQNTASGALYYNTKTHKYQYQQTSGA	30	lactococcin Z(Bacteriocin)	No entry found	Belongs to the class IId bacteriocin	lczA	Lactococcus lactis QU 7	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	"Lactococcin Z showed homology to lactococcins A, B and M."	None	Comment: No comments found on DRAMP database	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	26093857	Probiotics Antimicrob Proteins. 2015 Sep;7(3):222-31. 	"Ishibashi N, Seto H, Koga S, Zendo T, Sonomoto K."	"Identification of Lactococcus-Specific Bacteriocins Produced by Lactococcal Isolates, and the Discovery of a Novel Bacteriocin, Lactococcin Z."
DRAMP01952	FMGGLIKAATKALPAAFCAITKKC	24	"Brevinin-1PTb (Frogs, amphibians, animals)"	P0C8T2	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana picturata (Malaysian fire frog) (Hylarana picturata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 18-24."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923;##Gram-negative bacterium: Escherichia coli ATCC 25726.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01954	GLLDTLKNMAINAAKGAGQSVLNTLSCKLSKTC	33	"Brevinin-2HSb (Frogs, amphibians, animals)"	P0C8T0	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Odorrana hosii (Hose's rock frog) (Rana hosii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 27-33."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923;##Gram-negative bacterium: Escherichia coli ATCC 25726.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01958	GFLDSFKNAMIGVAKSAGKTALNTLACKIDKTC	33	"Brevinin-2PTd (Frogs, amphibians, animals)"	P0C8T6	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana picturata (Malaysian fire frog) (Hylarana picturata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the skin glands.
PTM: Contains one disulfide bond 27-33."	Gram-positive bacterium: Staphylococcus aureus ATCC 25923;##Gram-negative bacterium: Escherichia coli ATCC 25726.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization (Cys27 and Cys33)	Disulfide bond between Cys27 and Cys33.	L	No cytotoxicity information found	Not found	18621071	Toxicon. 2008 Sep 1;52(3):465-473. 	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD."	"Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)."
DRAMP01960	FLPILASLAAKFGPKLFCLVTKKC	24	"Brevinin-1BYa (Frogs, amphibians, animals)"	P84111	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana boylii (Foothill yellow-legged frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has hemolytic activity.	[Ref.14531844]Gram-positive bacterium:?Staphylococcus aureus(MIC=2 ?M);##Gram-negative bacterium:?Escherichia coli(MIC=17 ?M);##Yeast:?Candida albicans(MIC=3 ?M)	[Ref.14531844]HC50=4 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14531844	J Pept Res. 2003 Nov;62(5):207-213.	"Conlon JM, Sonnevend A, Patel M, Davidson C, Nielsen PF, P??l T, Rollins-Smith LA."	Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.
DRAMP01961	FLPILASLAAKLGPKLFCLVTKKC	24	"Brevinin-1BYb (Frogs, amphibians, animals)"	P84112	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana boylii (Foothill yellow-legged frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has hemolytic activity.	[Ref.14531844]Gram-positive bacterium:?Staphylococcus aureus(MIC=4 ?M);##Gram-negative bacterium:?Escherichia coli(MIC=16 ?M);##Yeast:?Candida albicans(MIC=16 ?M).	[Ref.14531844]HC50=4 ?M against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14531844	J Pept Res. 2003 Nov;62(5):207-213.	"Conlon JM, Sonnevend A, Patel M, Davidson C, Nielsen PF, P??l T, Rollins-Smith LA."	Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.
DRAMP01966	FLPVIAGVAANFLPKLFCAISKKC	24	"Brevinin-1Ya (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates yavapaiensis (North America leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	[Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=3 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=50 ¦ÌM);##Fungi : Candida albicans(MIC=12 ¦ÌM)	[Ref.19254736] LC50=18 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19254736	Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.	"Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis."
DRAMP01967	FLPIIAGAAAKVVQKIFCAISKKC	24	"Brevinin-1Yb (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Lithobates yavapaiensis (North America leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	[Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=3 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=25 ¦ÌM);##Fungi : Candida albicans(MIC=3 ¦ÌM)	[Ref.19254736] LC50=16 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19254736	Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018.	"Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD."	"Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis."
DRAMP01976	GIMDTLKNLAKTAGKGALQSLLNHASCKLSGQC	33	"Brevinin-2Eg (Frogs, amphibians, animals)"	P86154	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Pelophylax ridibundus (Marsh frog) (Rana ridibunda)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity."	[Swiss_Prot Entry P86154]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species	[Ref.18855342]show hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18855342	Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.	"Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT."	De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.
DRAMP18291	LAMVKYYGNGVSCNWRKHSCKKGLSVDWVYFGLLHNLGALRWYQHR	46	Garviecin LG34(Bacteriocin)	No entry found	Belongs to the class IIa bacteriocin	Not found	Lactococcus garvieae LG34	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	"Garviecin LG34 showed resistance to heat and low pH, and was sensitive to proteolytic enzymes but not to lipase and amylase."	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Food Control. 2015 Apr;50:896-900.	"Gao YR,Li DP,Liu S,Zhang LY."	"Garviecin LG34, a novel bacteriocin produced by Lactococcus garvieae isolated from traditional Chinese fermented cucumber."
DRAMP02012	VNPIILGVLPKFVCLITKKC	20	"Brevinin-1T (Brevinin-2T; Frogs, amphibians, animals)"	P82232	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antibacterial activity against representative Gram-negative and Gram-positive bacteria: and exhibits a very high hemolytic activity.	[Swiss_Prot Entry P82232]Antibacterial activity against representative Gram-negative and Gram-positive bacteria	[Ref.10333736]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	10333736	Biopolymers. 1998;47(6):435-450.	"Simmaco M, Mignogna G, Barra D."	Antimicrobial peptides from amphibian skin: what do they tell us?
DRAMP02013	FITLLLRKFICSITKKC	17	"Brevinin-1Ta (Frogs, amphibians, animals)"	P82233	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antibacterial activity against representative Gram-negative and Gram-positive bacteria: and exhibits no hemolytic activity.	[Swiss_Prot Entry P82233]Antibacterial activity against representative Gram-negative and Gram-positive bacteria	[Ref.10333736]Non-hemolytic	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	10333736	Biopolymers. 1998;47(6):435-450.	"Simmaco M, Mignogna G, Barra D."	Antimicrobial peptides from amphibian skin: what do they tell us?
DRAMP02016	FLSLALAALPKFLCLVFKKC	20	"Brevinin-1DYa (Frogs, amphibians, animals)"	P0C5W6	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antimicrobial peptide. Has hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 14-20.	[Swiss_Prot Entry P0C5W6]Gram-positive bacterium: Staphylococcus aureus (low activity);##Gram-negative bacterium: Escherichia coli (MIC<15 ?M).	[Ref.17688900]LC50<5 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17688900	Toxicon. 2007 Nov;50(6):746-756.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S."	"Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii."
DRAMP02017	GLLSAVKGVLKGAGKNVAGSLMDKLKCKLFGGC	33	"Brevinin-2DYa (Frogs, amphibians, animals)"	P0C5X1	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 27-33."	Gram-negative bacterium: Escherichia coli (MIC<15 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC<15 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17688900	Toxicon. 2007 Nov;50(6):746-756.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S."	"Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii."
DRAMP02018	FLSLALAALPKLFCLIFKKC	20	"Brevinin-1DYb (Brevinin-1CDYb; Frogs, amphibians, animals)"	P0C5W7	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has low activity against the Gram-positive bacteria: S. aureus and the Gram-negative bacteria E. coli. Has hemolytic activity. Has a strong hemolytic activity.
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 14-20."	[Swiss_Prot Entry P0C5W7]Gram-positive bacterium: Staphylococcus aureus (low activity);##Gram-negative bacterium: Escherichia coli (MIC<15 ?M).	[Ref.17688900]LC50<6 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19539775##17688900	Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.##Toxicon. 2007 Nov;50(6):746-756. 	"Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.##Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S."	"Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.##Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii."
DRAMP02020	FLPLLLAGLPKLLCLFFKKC	20	"Brevinin-1DYc (Frogs, amphibians, animals)"	P0C5W8	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana dybowskii (Dybovsky's frog) (Korean brown frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial peptide. Has low activity against the Gram-positive bacteria: S. aureus and the Gram-negative bacteria E.coli (MIC<15 ?M). Has hemolytic activity. 
Tissue specificity: Expressed by the skin glands.
PTM: contains one disulfide bond 14-20."	[Swiss_Prot Entry P0C5W8]Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli (MIC<15 ?M).	[Ref.17688900]LC50<7 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17688900	Toxicon. 2007 Nov;50(6):746-756.	"Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S."	"Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii."
DRAMP18281	GRADYNFGYGLGRGTRKFFNGIGRWVRKTF	30	Plantaricin KL-1Y (Bacteriocin)	No entry found	Belongs to the class IIb bacteriocin	Not found	Lactobacillus plantarum KL-1	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	"It showed synergistic effects with KL-1X and KL-1Z, two additional peptides whose sequences have not been established."	"Gram-positive, Gram-negative (broad-spectrum)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	25862353	World J Microbiol Biotechnol. 2015 Jun;31(6):983-94. 	"Rumjuankiat K, Perez RH, Pilasombut K, Keawsompong S, Zendo T, Sonomoto K, Nitisinprasert S."	"Purification and characterization of a novel plantaricin, KL-1Y, from Lactobacillus plantarum KL-1."
DRAMP02089	FLPMLAGLAASMVPKLVCLITKKC	24	"Brevinin-1La (Brevinin-1PRd; Frogs, amphibians, animals)"	P82825	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana luteiventris (Spotted frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Brevinin-1PRd isolated from the Oregon spotted frog shares the same sequence with this entry.	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP01124	ILGPVLSMVGSALGGLIKKI	20	"Maximin-H2 (Toads, amphibians, animals)"	P83082	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi.Shows strong hemolytic activity. "	"[Ref.11835991] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=20 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=2 ¦Ìg/ml), Bacillus pyocyaneus CMCCB 1010 (MIC=4 ¦Ìg/ml);##Fungi: Candida albicans ATCC 2002 (MIC=2 ¦Ìg/ml)."	[Ref:11835991]90¨C100% hemolytic activity at 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP01123	ILGPVISTIGGVLGGLLKNL	20	"Maximin-H1 (Toads, amphibians, animals)"	"P83080, P83081, Q58T74, Q58T41"	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Shows strong hemolytic activity. "	"[Ref.11835991] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=9 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=4.5 ¦Ìg/ml), Bacillus pyocyaneus CMCCB 1010 (MIC=9 ¦Ìg/ml).##Yeast: Candida albicans ATCC 2002 (MIC=4.5 ¦Ìg/ml)."	[Ref:11835991]90¨C100% hemolytic activity at 50 ¦Ìg/ml against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP01111	SIGAKILGGVKTFFKGALKELASTYLQ	27	"Maximin-5 (Toads, amphibians, animals)"	"P83084, Q58T60, Q58T61"	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer"	Protein level	Not found	Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins.	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. No amidation at the C-terminus.
Tissue specificity: Expressed by the skin glands."	"[Ref.11835991] Gram-negative bacterium: Klebsiella pneumoniae (MIC=3.6 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.6 ¦Ìg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.2 ¦Ìg/ml), Bacillus megatherium (MIC=12 ¦Ìg/ml), Bacillus dysenteriae (MIC=12 ¦Ìg/ml).##Fungi: Candida albicans ATCC 2002 (MIC=1.2 ¦Ìg/ml), Aspergillus flavus IFFI 4015 (MIC=12 ¦Ìg/ml), Penicillium uticale IFFI 2001 (MIC=12 ¦Ìg/ml);##Virus: HIV-1 (IC50=34.4 ¦Ìg/ml, EC50=39.8 ¦Ìg/ml);##Cancer cell lines: C8166 (IC50=34.4 ¦Ìg/ml)."	[Ref:11835991]Little hemolytic activity at 50 ¦Ìg/ml against red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP01110	GIGGVLLSAGKAALKGLAKVLAEKYAN	27	"Maximin-4 (Toads, amphibians, animals)"	"P83083, Q58T42, Q58T44, Q58T52, Q58T62, Q58T77, Q58T79"	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer"	Protein level	Not found	Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins.	2MHW resolved by NMR	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity."	"[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2.7 ?g/ml), Klebsiella pneumoniae (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=2.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 ?g/ml), Bacillus megatherium (MIC=1.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=15 ?g/ml);##Virus: HIV-1 (IC50=24.2 ?g/ml, EC50=21.9 ?g/ml);##Cancer cell lines: C8166 (IC50=24.2 ?g/ml), Molt-4 (IC50=35.4 ?g/ml)."	[Ref:11835991]Little hemolytic activity at 50 ¦Ìg/ml against red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP01109	GIGGKILSGLKTALKGAAKELASTYLH	27	"Maximin-3 (Toads, amphibians, animals)"	"P83082, Q58T40, Q58T43, Q58T46, Q58T48, Q58T64, Q58T65, Q58T68, Q58T69"	Belongs to the bombinin family	Not found	Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer"	Protein level	Not found	Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins.	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity. No amidation at the C-terminus.
Toxic dose: LD50 is 4.3 mg/kg by intraperitoneal injection into mice.
Tissue specificity: Expressed by the skin glands."	"[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.9 ?g/ml), Klebsiella pneumoniae (MIC=3.1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=1.5 ?g/ml), Bacillus megatherium (MIC=0.9 ?g/ml), Bacillus dysenteriae (MIC=0.9 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=15 ?g/ml);##Virus: HIV-1 (IC50=11.4 ?g/ml, EC50=1.5 ?g/ml);##Cancer cell lines: C8166 (IC50=11.4 ?g/ml), Molt-4 (IC50=25.2 ?g/ml), BIU-87 (IC50=28 ?g/ml), T24 (IC50=18 ?g/ml)."	[Ref:11835991]Little hemolytic activity at 50 ¦Ìg/ml against red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	15770703##11835991	Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435.	"Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y."	Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
DRAMP02100	FLPIIASVAAKVFPKIFCAISKKC	24	"Brevinin-1Pe (Frogs, amphibians, animals)"	P82845	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pipiens (Northern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP18272	MAKEFGIPAAVAGTVINVVVAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW	70	Enterocin AS-48RJ (Bacteriocin)	No entry found	Belongs to the class IIc bacteriocin	Not found	Enterococcus faecium RJ16	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Not found	1E68 resolved by NMR	"This is a natural variant of AS-48, where residue 20 is a Glu (Val in As-48RJ). It has the same activity spectrum as  AS-48 . "	"Gram-positive, Gram-negative (broad-spectrum)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16094865	Syst Appl Microbiol. 2005 Jul;28(5):383-97.	"Abriouel H, Lucas R, Ben Omar N, Valdivia E, Maqueda M, Mart"	Enterocin AS-48RJ: a variant of enterocin AS-48 chromosomally encoded by Enterococcus faecium RJ16 isolated from food.
DRAMP02132	GLASTLGSFLGKFAKGGAQAFLQPK	25	"Antimicrobial peptide 3 (XT-3; Levitide-like peptide; Frogs, amphibians, animals)"	P84383	Belongs to the gastrin/cholecystokinin family (Magainin subfamily)	Not found	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli, when in combination with XT1 and XT6."	Gram-positive bacteria: Staphylococcus aureus;##Gram-negative bacteria: E.coli (Combination with XT1 and XT6).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11738090	Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.	"Ali MF, Soto A, Knoop FC, Conlon JM."	"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)."
DRAMP02134	GMATKAGTALGKVAKAVIGAAL	22	"Antimicrobial peptide 5 (XT-5; PGLa-like peptide; Frogs, amphibians, animals)"	P84385	Not found	Not found	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity against Gram-positive bacterium S. aureus, Gram-negative bacterium E.coli and yeast C. albicans. Has strong hemolytic activity against human red blood cells.
Tissue specificity: Skin."	[Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria: Escherichia coli (MIC>100 ?M);##Fungi: Candida albicans (MIC>100 ?M)	[Ref.11738090]HC50>150 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	11738090	Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89.	"Ali MF, Soto A, Knoop FC, Conlon JM."	"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)."
DRAMP02086	FLPVLTGLTPSIVPKLVCLLTKKC	24	"Brevinin-1PRa (frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pretiosa (North oregon spotted frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: activity against reference strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae) and Gram-positive (Staphlococcus aureus) bacteria but displayed relatively low hemolytic activity. "	[Ref.15003829] Gram-negative bacterium: Escherichia coli(MIC>100¦ÌM);## Gram-positive bacterium: Staphylococcus aureus(MIC=13¦ÌM);## Yeast: Candida albicans(MIC=100¦ÌM).[Ref.21295070] Gram-negative bacterium: Escherichia coli(MIC>100¦ÌM);## Gram-positive bacterium: Staphylococcus aureus(MIC=50¦ÌM);## Yeast: Candida albicans(MIC=100¦ÌM).	[Ref.15003829] HC50=7¦ÌM against human erythrocytes.##[Ref.21295070] LC50= 150¦ÌM against human erythrocytes.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	15003829##21295070	Regul Pept. 2004 May 15;118(3):135-141.## Dev Comp Immunol. 2011 Jun;35(6):644-649. 	"Conlon JM, Sonnevend A, Patel M, Al-Dhaheri K, Nielsen PF, Kolodziejek J, Nowotny N, Iwamuro S, P"	"A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica.## Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis."
DRAMP02243	GLLSGLKKVGKHVAKNVAVSLMDSLKCKISGDC	33	"Ranatuerin-1T (Brevinin-2T; Frogs, amphibians, animals)"	"P82740, P82236"	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10422869##10333736	Peptides. 1999;20(2):159-163.##Biopolymers. 1998;47(6):435-450.	"Goraya J, Knoop FC, Conlon JM.##Simmaco M, Mignogna G, Barra D."	"Ranatuerin 1T: an antimicrobial peptide isolated from the skin of the frog, Rana temporaria.##Antimicrobial peptides from amphibian skin: what do they tell us?"
DRAMP02249	AIMDTIKDTAKTVAVGLLNKLKCKITGC	28	"Ranatuerin-2SEB (Frogs, amphibians, animals)"	P85058	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sevosa (dusky gopher frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli K12;##Gram-positive bacterium: Micrococcus luteus NCT C2665.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16386333	Peptides. 2006 Jun;27(6):1313-1319.	"Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C."	"Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa."
DRAMP02250	GIMDTIKDTAKTVAVGLLNKLKCKITGC	28	"Ranatuerin-2SEC (Frogs, amphibians, animals)"	P85053	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana sevosa (dusky gopher frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli K12;##Gram-positive bacterium: Micrococcus luteus NCT C2665.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16386333	Peptides. 2006 Jun;27(6):1313-1319.	"Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C."	"Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa."
DRAMP02253	GIMDSVKGLAKNLAGKLLDSLKCKITGC	28	"Ranatuerin-IIbYb (Ranatuerin-2bYa; Frogs, amphibians, animals)"	P84115	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana boylii (Foothill yellow-legged frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14531844	J Pept Res. 2003 Nov;62(5):207-213.	"Conlon JM, Sonnevend A, Patel M, Davidson C, Nielsen PF, P??l T, Rollins-Smith LA."	Isolation of peptides of the brevinin-2 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.
DRAMP02258	GILSTFKGLAKGVAKDLAGNLLDKFKCKITGC	32	"Ranatuerin-IIbYa (Ranatuerin-2bYa; Frogs, amphibians, animals)"	P84114	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana boylii (Foothill yellow-legged frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Show weak hemolytic activity.	[Ref.14531844]Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus	[Ref.14531844]HC50=120 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14531844	J Pept Res. 2003 Nov;62(5):207-213.	"Conlon JM, Sonnevend A, Patel M, Davidson C, Nielsen PF, P??l T, Rollins-Smith LA."	Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.
DRAMP02284	GLNTLKKVFQGLHEAIKLINNHVQ	24	"Pseudin-1 (Pseudin 1; Frogs, amphibians, animals)"	P83188	Not found	Not found	Pseudis paradoxa (Paradoxical frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Possesses antifungal activity against C. albicans and is also active against E. coli and S. aureus.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus.##Yeast: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11689009	Biochem Biophys Res Commun. 2001 Nov 9;288(4):1001-1005.	"Olson L 3rd, Soto AM, Knoop FC, Conlon JM."	Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog.
DRAMP02285	GLNALKKVFQGIHEAIKLINNHVQ	24	"Pseudin-2 (Pseudin 2; Frogs, amphibians, animals)"	P83189	Not found	Not found	Pseudis paradoxa (Paradoxical frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Possesses antifungal activity against C. albicans and is also active against E. coli and S. aureus. Has low hemolytic activity against human erythrocytes.
Tissue specificity: Expressed by the skin glands."	[Ref.11689009]Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus;##Yeast: Candida albicans	[Ref.11689009]50% hemolysis of human erythrocytes is >300 ¦ÌM	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11689009	Biochem Biophys Res Commun. 2001 Nov 9;288(4):1001-1005.	"Olson L 4rd, Soto AM, Knoop FC, Conlon JM."	Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog.
DRAMP02286	GINTLKKVIQGLHEVIKLVSNHE	23	"Pseudin-3 (Pseudin 3; Frogs, amphibians, animals)"	P83190	Not found	Not found	Pseudis paradoxa (Paradoxical frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Possesses antifungal activity against C. albicans and is also active against E. coli and S. aureus.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus;##yeast Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11689009	Biochem Biophys Res Commun. 2001 Nov 9;288(4):1001-1005.	"Olson L 5rd, Soto AM, Knoop FC, Conlon JM."	Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog.
DRAMP02287	GINTLKKVIQGLHEVIKLVSNHA	23	"Pseudin-4 (Pseudin 4; Frogs, amphibians, animals)"	P83191	Not found	Not found	Pseudis paradoxa (Paradoxical frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix 	Not found	None	"Function: Possesses antifungal activity against C. albicans and is also active against E. coli and S. aureus.
Tissue specificity: Expressed by the skin glands."	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus;##yeast Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11689009	Biochem Biophys Res Commun. 2001 Nov 9;288(4):1001-1005.	"Olson L 6rd, Soto AM, Knoop FC, Conlon JM."	Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog.
DRAMP02309	IIGHLIKTALGFLGL	15	"Signiferin-2.2 (Frogs, amphibians, animals)"	P86132	Not found	Not found	Crinia signifera (Common eastern froglet)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against a wide spectrum of Gram-positive bacteria. Lacks antibacterial activity against the Gram-negative bacteria E. cloacae and E. coli.
Tissue specificity: Expressed by the skin glands.
PTM: C-terminal amidation."	"Gram-negative bacteria: Enterobacter cloacae ATCC 13047 (MIC¡Ü100 ?M), Escherichia coli ATCC3 5218 (MIC¡Ü100 ?M)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15317042##16470724##18601958	Rapid Commun Mass Spectrom. 2004;18(18):2155-2161.##Rapid Commun Mass Spectrom. 2006;20(5):797-803.##Regul Pept. 2008 Nov 29;151(1-3):80-87.	"Maselli VM, Brinkworth CS, Bowie JH, Tyler MJ.##Maselli VM, Bilusich D, Bowie JH, Tyler MJ.##Jackway RJ, Pukala TL, Maselli VM, Musgrave IF, Bowie JH, Liu Y, Surinya-Johnson KH, Donnellan SC, Doyle JR, Llewellyn LE, Tyler MJ."	"Host-defence skin peptides of the Australian Common Froglet Crinia signifera: sequence determination using positive and negative ion electrospray mass spectra.##Host-defence skin peptides of the Australian Streambank Froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry.##Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: structure, activity and evolutionary trends."
DRAMP02332	FIHHIFRGIVHAGRSIGRFLTG	22	"Piscidin-3 (Pis-3; fish, chordates, animals)"	P0C006	Belongs to the pleurocidin family	Not found	Morone chrysops x Morone saxatilis (white bass x striped sea-bass)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Protein level	Not found	Not found	None	"Function: Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has hemolytic activity.
Tissue specificity: Mast cells in gill, skin and gut, and in lining blood vessels in the viscera."	[Swiss_Prot Entry P0C006]broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria	[Ref.11713517]5% hemolytic activity at 100 ¦Ìg/mL against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11713517	Nature. 2001 Nov 15;414(6861):268-269.	"Silphaduang U, Noga EJ."	Peptide antibiotics in mast cells of fish.
DRAMP01375	GLGGAKKNFIIAANKTAPQSVKKTFSCKLYNG	32	"Odorranain-E1 (OdE1; Frogs, amphibians, animals)"	A6MBK8	Not found	Not found	Odorrana grahami (Yunnanfu frog) (Rana grahami)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Odorranain-E1 adopts 100% turn structure in water solution.	None	Function: Odorranain-E1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.	"[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=9.37 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 ¦Ìg/ml), Bacillus subtilis (MIC=4.68 ¦Ìg/ml).##Yeast: Candida albicans (MIC=9.37 ¦Ìg/ml)."	[Ref:17272268]Non-hemolytic activity against rabbit red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17272268	Mol Cell Proteomics. 2007 May;6(5):882-894.	"Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J."	Anti-infection peptidomics of amphibian skin.
DRAMP02353	RSTEDIIKSISGGGFLNAMNA	21	"Pleurocidin-like peptide WFX (fish, chordates, animals; Predicted)"	Q7T053	Not found	ple6	Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	Function: Has antibacterial and antifungal activity.	"Gram-negative bacteria: Aeromonas salmonicida A449 field isolate (MIC>64 ?g/ml), A. salmonicida 97-4 field isolate (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC>64 ?g/ml), Escherichia coli (MIC>64 ?g/ml), Salmonella typhimurium 14028s (MIC>64 ?g/ml), S. typhimurium MS7953s (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis (human clinical isolates) (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) (MIC>64 ?g/ml).##Fungi: Candida albica (MIC>64 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12950255	Eur J Biochem. 2003 Sep;270(18):3720-3730.	"Douglas SE, Patrzykat A, Pytyck J, Gallant JW."	"Identification, structure and differential expression of novel pleurocidins clustered on the genome of the winter flounder, Pseudopleuronectes americanus (Walbaum)."
DRAMP02369	LLAWCLVFLVIVQQVTSSPVPQSDTPLTSVQEVQRSLKRTARMTPLWRIMGTKPHGAYCQNHYECSTGICRKGHCSYS	78	"Liver-expressed antimicrobial peptide 2 (fish, chordates, animals)"	D0Q093	Not found	LEAP-2	Ctenopharyngodon idella (Grass carp) (Leuciscus idella)	"Antimicrobial, Antibacterial, Anti-Gram-"	Predicted	Not found	Not found	None	"Grass carp LEAP-2 gene is expressed in a wide range of tissues except blood, with the highest level of transcripts found in liver. "	Gram-negative bacteria: Escherichia coli XC-1 and Aeromonas hydrophila S2.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19716607	Vet Immunol Immunopathol. 2010 Feb 15;133(2-4):133-143.	"Liu F, Li JL, Yue GH, Fu JJ, Zhou ZF."	Molecular cloning and expression analysis of the liver-expressed antimicrobial peptide 2 (LEAP-2) gene in grass carp.
DRAMP02245	GLFLDTLKGLAGKLLQGLKCIKAGCKP	27	"Ranatuerin-2Cb (Ranatuerin 2Cb; Frogs, amphibians, animals)"	P82879	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana clamitans (Green frog) (Lithobates clamitans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. 
Tissue specificity: Expressed by the skin glands."	[Ref.10822101] Gram-positive bacterium: Staphylococcus aureus (MIC=40 ¦Ìg/ml);##Gram-negative bacterium: Escherichia coli (MIC=2 ¦Ìg/ml).##Yeast: Candida albicans (MIC=46 ¦Ìg/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10822101	Peptides. 2000 Apr;21(4):469-476.	"Halverson T, Basir YJ, Knoop FC, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
DRAMP02398	GPVGLLSSPGSLPPVGGAP	19	Antimicrobial peptide GP-19 (GP-19)	B3A0L2	Not found	Not found	Xenorhabdus budapestensis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: GP-19 displays broad-spectrum antimicrobial activity against the tested bacteria and fungi.	"Gram-positive bacteria: Bacillus subtilis (IZ=19.04¡À0.2 mm), Bacillus megaterium (IZ=7.3¡À0.28 mm), Prototheca wickerhamii (IZ=10.3¡À0.33 mm);##Gram-negative bacteria: Xanthomonas campestris pv. vesicatoria (IZ=16.47¡À0.35 mm), Pseudomonas solanacearum (IZ=10.75¡À0.41 mm).##fungi: Phytophthora capsici (CD=16.62¡À1.07 mm), Verticillium dahlia (EC50=17.54 ?g/ml), Fusarium graminearum (CD=12.04¡À0.87 mm), Fusarium omysporum (CD=21.64¡À0.4 mm).##NOTE: IZ = Inhibition Zone and CD = Colony diameter."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22497806	Peptides. 2012 Jun;35(2):253-260.	"Xiao Y, Meng F, Qiu D, Yang X."	Two novel antimicrobial peptides purified from the symbiotic bacteria Xenorhabdus budapestensis NMC-10.
DRAMP02400	GCPQTPRCTNYAEKGQCPPN	20	Antimicrobial peptide AJN-10 (AJN-10)	P0DJ30	Not found	Not found	Anguilla japonica (Japanese eel)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Displays antimicrobial activity against the Gram-negative bacterium A.hydrophila.	Gram-negative bacterium: Aeromonas hydrophila.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21796440	Protein J. 2011 Aug;30(6):413-421.	"Liang Y, Guan R, Huang W, Xu T."	"Isolation and identification of a novel inducible antibacterial peptide from the skin mucus of Japanese eel, Anguilla japonica."
DRAMP02407	PAQPFRIKKRQGPFERP	17	Napin-like polypeptide (Contains: Napin-like polypeptide small chain and large chain)	P84782	Belongs to the 2S seed storage albumins family	Not found	Brassica oleracea var. alboglabra (Chinese kale) (Brassicaalboglabra)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Inhibits cell-free protein synthesis. Inhibits trypsin and chymotrypsin. Does not inhibit ribonuclease of protease activity. Has antibacterial activity except Gram-positive bacterium S. aureus or the Gram-negative bacteria E. coli, E. aerogenes, P. aeruginosa and P. vulgaris. Inhibits the proliferation of leukemia cells in vitro.
Subunit structure: The mature protein consists of a small and a large chain linked by disulfide bonds (sequence shown is small chain).
Biophysicochemical properties: This activity is preserved between pH 5 and pH 11, and between 10 and 40 degrees C. It falls to a low level at pH 3 and pH 13 and at 70 degrees C."	"Gram-negative bacterium: Pseudomonas fluorescens (IC50=89¡À6.1 ?M);##Gram-positive bacteria: Bacillus subtilis (IC50=278¡À12.9 ?M), B. cereus (IC50=145¡À83 ?M), Bacillus megaterium (IC50=156¡À8.4 ?M), Megabacterium phlei (IC50=104¡À27 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15485558	J Pept Res. 2004 Nov;64(5):202-208.	"A napin-like polypeptide with translation-inhibitory, trypsin-inhibitory, antiproliferative and antibacterial activities from kale seeds."	"A napin-like polypeptide with translation-inhibitory, trypsin-inhibitory, antiproliferative and antibacterial activities from kale seeds."
DRAMP02437	GFWKKVGSAAWGGVKAAAKGAAVGGLNALAKHIQ	34	Papillosin	P86416	Not found	Not found	Halocynthia papillosa (Red sea-squirt)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has strong antibacterial activity against the Gram-positive bacteria M. luteus, S. aureus, B. megaterium, A. viridans and E. faecalis, and against the Gram-negative bacteria K. pneumoniae, E. coli DH5alpha, S. typhimurium, P. aeruginosa and E. aerogenes. Lacks hemolytic activity against sheep erythrocytes."	"[Ref.19085906]Gram-positive bacteria (Native, Synthetic): Micrococcus luteus A270 (MBC=0.13-0.25, 0.19-0.39 ?M), Aerococcus viridans 54.145 T (MBC=ND, 0.19-0.39 ?M), Bacillus megaterium 66.20 T (MBC=ND, 0.05-0.10 ?M), Staphylococcus aureus 65.8 T (MBC=0.5-1.00, 1.56-3.13 ?M), Enterococcus faecalis 103015 T (MBC=ND, 0.78-1.56 ?M);##Gram-negative bacteria (Native, Synthetic): Enterobacter aerogenes 30.86 T (MBC=ND, 0.78-1.56 ?M), Pseudomonas aeruginosa 100720 T (MBC=ND, 3.13-6.25 ?M), Salmonella thyphimurium 60.62 T (MBC=ND, 0.78-1.56 ?M), Klebsiella pneumoniae 82.91 T (MBC=ND, 0.39-0.78 ?M), Escherichia coli (MBC=0.25-0.50, 0.78-1.56 ?M)"	[Ref.19085906]0% hemolytic activity at 50 ¦ÌM against sheep erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19085906	J Pept Sci. 2009 Jan;15(1):48-55.	"Galinier R, Roger E, Sautiere PE, Aumelas A, Banaigs B, Mitta G."	"Halocyntin and papillosin, two new antimicrobial peptides isolated from hemocytes of the solitary tunicate, Halocynthia papillosa."
DRAMP02438	FWGHIWNAVKRVGANALHGAVTGALS	26	Halocyntin	P86415	Not found	Not found	Halocynthia papillosa (Red sea-squirt)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has strong antibacterial activity against the Gram-positive bacteria M. luteus, S. aureus, B. megaterium, A. viridans and E. faecalis, and against the Gram-negative bacterium K. pneumoniae. Has less potent antibacterial activity against the Gram-negative bacteria E. coli DH5alpha, S. typhimurium, P. aeruginosa, E. aerogenes and N. gonorrhoeae. Has moderate hemolytic activity against sheep erythrocytes."	"[Ref.19085906]Gram-positive bacteria (Native, Synthetic): Micrococcus luteus A270 (MBC=0.39-0.78, 0.39-0.78 ?M), Aerococcus viridans 54.145 T (MBC=3.13-6.25, 0.78-1.56 ?M), Bacillus megaterium 66.20 T (MBC=0.75-1.56, 0.39-0.78 ?M), Staphylococcus aureus 65.8 T (MBC=6.25-12.50, 1.56-3.13 ?M), Enterococcus faecalis 103015 T (MBC=6.25-12.50, 1.56-3.13 ?M);##Gram-negative bacteria (Native, Synthetic): Enterobacter aerogenes 30.86 T (MBC=25-50, 6.25-12.50 ?M), Pseudomonas aeruginosa 100720 T (MBC>100, 25-50 ?M), Salmonella thyphimurium 60.62 T (MBC=50-100, 12.50-25 ?M), Klebsiella pneumoniae 82.91 T (MBC=12.50-25, 1.56-3.13 ?M), Neisseria gonorrhoeae 103711 (MBC=25-50, ND ?M), Escherichia coli (MBC=6.25-12.50, 6.25-12.50 ?M)."	"[Ref.19085906]8% hemolytic activity at 6.25 ¦ÌM, 13% hemolytic activity at 12.5 ¦ÌM, 14% hemolytic activity at 25 ¦ÌM, 22% hemolytic activity at 50 ¦ÌM against sheep erythrocytes "	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19085906	J Pept Sci. 2009 Jan;15(1):48-55.	"Galinier R, Roger E, Sautiere PE, Aumelas A, Banaigs B, Mitta G."	"Halocyntin and papillosin, two new antimicrobial peptides isolated from hemocytes of the solitary tunicate, Halocynthia papillosa."
DRAMP02447	FCKSLPLPLSVK	12	Antimicrobial protein 2 (Antimicrobial protein AN5-2)	B3EWQ7	Not found	Not found	Paenibacillus alvei (Bacillus alvei)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has antibacterial activity Gram-positive bacteria as well as against Gram-negative bacteria.	Gram-positive bacteria: Lactobacillus plantarum strain ATCC 8014 and Bacillus cereus strain ATCC 14579;##Gram-negative bacteria: Escherichia coli strain ATCC 25922 and Salmonella enteritidis strain ATCC 13076.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (JUL-2012) to UniProtKB	"Alkotaini B, Anuar N, Kadhum AAH."	Unknown
DRAMP02453	GKIPVKAIKKAGAAIGKGLRAINIASTAHDVYSFFKPKHKKK	42	"S. litura moricin (Sl moricin; Insects, animals)"	Q7YZB4	Not found	Not found	Spodoptera litura (Lepidopteran insect)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix (1 helices; 31 residues)	"The solution structure of Sl moricin is determined by two-dimensional (2D) 1H-nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-simulated annealing calculation. The tertiary structure reveales a long alpha-helix containing eight turns along nearly the full length of the peptide like that of moricin, confirming that Sl moricin is a new moricin-like antibacterial peptide."	1X22 resolved by NMR. 	Function: Sl moricin showes a broad antibacterial spectrum against Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa (LD50=67.4 ?g/ml), Escherichia coli JM109 (LD50=5.2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (LD50=2.7 ?g/ml), Methicillin-resistant S. aureus (LD50=9.8 ?g/ml), Micrococcus luteus (LD50=28.4 ?g/ml), Bacillus thuringiensis HD-1 (LD50=0.5 ?g/ml), Enterococcus faecium IFO3128 (LD50=6.2 ?g/ml). "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16115804	Biochim Biophys Acta. 2005 Aug 31;1752(1):83-92.	"Oizumi Y, Hemmi H, Minami M, Asaoka A, Yamakawa M."	"Isolation, gene expression and solution structure of a novel moricin analogue, antibacterial peptide from a lepidopteran insect, Spodoptera litura."
DRAMP02454	GCFEDWSRCSPSTASATGVLWRSCDSYCKVCFKADRGECYDSPSLNCPHRLPNNKQCRCINARTAKDNRNPTCWA	75	"Theromacin (Arthropods, animals)"	"A8I0L8, A8IK85"	Not found	Not found	Hirudo medicinalis (Medicinal leech)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	Structural features of Theromacin: the characteristic additional N-terminal helix and two long flexible loops separating the two helices.	2LN8 resolved by NMR.	"Function: It showes antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria in the low microgram concentration range.
PTM: Problely contains five disulfide bonds 2-9; 24-28; 31-73; 39-47; 57-59."	"Gram-negative bacterium: Escherichia coli ATCC 35218 (LD90=6.25 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (LD90=25 ?g/ml), Bacillus megaterium ATCC 14581 (MBC=0.2-0.39 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22396551##PubMed ID is not available	J Biol Chem. 2012 Apr 20;287(17):14246-58.##Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases	"Jung S, S?nnichsen FD, Hung CW, Tholey A, Boidin-Wichlacz C, Haeusgen W, Gelhaus C, Desel C, Podschun R, Waetzig V, Tasiemski A, Leippe M, Gr?tzinger J.##Schikorski D, Salzet M, Tasiemski A."	Macin family of antimicrobial proteins combines antimicrobial and nerve repair activities.##Antimicrobial peptides isolated from the medicinal leech.
DRAMP02457	ADVRNPLEEFRETDYEVL	18	"L-amino-acid oxidase (Balt-LAAO-I; LAAO; LAO; snakes, reptils, animals)"	P0DI86	Belongs to the flavin monoamine oxidase family (FIG1 subfamily)	Not found	Bothrops alternatus (Urutu)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as slight hemorrhage, Induction: of platelet aggregation, edema in the mouse paw and bactericidal activity against both Gram-positive (S.aureus) and Gram-negative (E.coli) bacteria. May also induce hemolysis, apoptosis of vascular endothelial cells or tumor cell lines, and may have antiparasitic activities. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions. 
Tissue specificity: Expressed by the venom gland."	Gram-positive bacterium: S. aureus;##Gram-negative bacterium: E. coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15142548	Bioorg Med Chem. 2004 Jun 1;12(11):2881-2886.	"St¨¢beli RG, Marcussi S, Carlos GB, Pietro RC, Selistre-de-Ara¨²jo HS, Giglio JR, Oliveira EB, Soares AM."	Platelet aggregation and antibacterial effects of an L-amino acid oxidase purified from Bothrops alternatus snake venom.
DRAMP02462	DDRRSPLEECFQQNDYEEFLEIARNSQLYQESLREDSSYHLSFIESLKSDALFSYEKKFWEADGIHGGKVINDLSLIHDLPKREIQALCYPSIKK	95	"L-amino-acid oxidase (LAAO; LAO; snakes, reptils, animals)"	P0DI91	Belongs to the flavin monoamine oxidase family (FIG1 subfamily)	Not found	Naja oxiana (Central Asian cobra) (Oxus cobra)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic"	Protein level	Not found	Not found	None	"Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as antibacterial activity against both Gram-positive (B.subtilis) and Gram-negative (E.coli) bacteria, and inhibition of ADP- or collagen-induced platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions. This protein may also induce hemorrhage, hemolysis, edema, apoptosis, and have antiparasitic activities.
Tissue specificity: Expressed by the venom gland.
Biophysicochemical properties: Kinetic parameters (KM=0.885 mM for L-Met; KM=0.051 mM for L-Phe; KM=0.147 mM for L-Trp; KM=0.75 mM for L-Leu)"	Gram-positive bacterium: Bacillus subtilis;##Gram-negative bacterium: E. coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18294891	Comp Biochem Physiol B Biochem Mol Biol. 2008 Apr;149(4):572-580.	"Samel M, T?nism?gi K, R?nnholm G, Vija H, Siigur J, Kalkkinen N, Siigur E."	L-Amino acid oxidase from Naja naja oxiana venom.
DRAMP02511	YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG	42	"Crotamine (defensin-like toxin; Snakes, reptiles, animals)"	Q9PWF3	Belongs to the crotamine-myotoxin family	CRO2	Crotalus durissus terrificus (South American rattlesnake)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytotoxic, Antifungal"	Protein level	Combine helix and strand structure	"Crotamine contains an alpha-helix with residues 1-7 and a two-stranded anti-parallel beta-sheet with residues 9-13 and 34-38 as the only regular secondary structures. These are connected with each other and the remainder of the polypeptide chain by the three disulfide bonds, which also form part of a central hydrophobic core (Ref.2)."	1Z99 resolved by NMR.	"Function: It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism. As a cell-penetrating peptide, crotamine has high specificity for actively proliferating cells, and interacts inside the cell with subcellular and subnuclear structures, like vesicular compartments, chromosomes and centrioles. Crotamine has marked activity against the eukaryotic pathogen Candida albicans at pH 7.5 or 5.5.
Tissue specificity: Expressed by the venom gland.
Toxic dose: LD50 is 1.5 mg/kg by intravenous injection. LD50 is 32.8 mg/kg by intraperitoneal injection into mice.(Ref.3)(Ref.4)
Pharmaceutical use: Has high potential for use as an anticancer agent. In vivo treatment with this protein significantly delays tumor implantation, inhibits tumor growth and prolongs the lifespan of the mice with melanoma tumors. It has also potent and specific toxicity against tumor cell lines of aggressive mouse and human tumors, but low cytotoxicity against non-tumoral cell lines. In addition, this protein can act as a carrier capable of delivering DNA into replicating cells with low cytotoxicity against normal proliferative cells.(Ref.5)(Ref.6)
Miscellaneous: Has no hemolytic activity ."	[Swiss_Prot Entry Q9PWF3]Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacteria: Escherichia coli;##Yeast: Candida albicans	[Ref.210622]Non-hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Eukaryotic ion channels	19706485##16185738##1176086##9839677##22142367##210622	Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-14977.##Toxicon. 2005 Dec 1;46(7):759-767.##Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-215.##Toxicon. 1998 Dec;36(12):1927-1937.##Mol Pharm. 2012 Feb 6	"Yount NY, Kupferwasser D, Spisni A, Dutz SM, Ramjan ZH, Sharma S, Waring AJ, Yeaman MR.##Fadel V, Bettendorff P, Herrmann T, de Azevedo WF Jr, Oliveira EB, Yamane T, W¨¹thrich K.##Laure CJ.##Mancin AC, Soares AM, Andri?o-Escarso SH, Fa?a VM, Greene LJ, Zuccolotto S, Pel¨¢ IR, Giglio JR.##Nascimento FD, Sancey L, Pereira A, Rome C, Oliveira V, Oliveira EB, Nader HB, Yamane T, Kerkis I, Tersariol IL, Coll JL, Hayashi MA.##Kerkis I, Silva "	"Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine.##Automated NMR structure determination and disulfide bond identification of the myotoxin crotamine from Crotalus durissus terrificus.##The primary structure of crotamine (author's transl).##he analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study.##The natural cell-penetrating peptide crotamine targets tu"
DRAMP04532	GIHDILKYGKPS	12	"Myxinidin (Hagfish, animals)"	No entry found	Not found	Not found	Myxine glutinosa (Atlantic hagfish)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Myxinidin showed activity against a broad range of bacteria and yeast pathogens at minimum bactericidal concentration (MBC) ranging from 1.0 to 10.0 	"[Ref.19330556] Gram-negative bacteria: Escherichia coli D31 (MBC=2.0 ¦Ìg/ml), Salmonella enterica serovar Typhimurium C610 (MBC=2.5 ¦Ìg/mL), Pseudomonas aeruginosa Z61 (MBC=7.0¦Ìg/ml), Pseudomonas aeruginosa K799 (MBC=10.0 ¦Ìg/ml), Aeromonas salmonicida sub sp. salmonicida A449 (MBC=2.0 ¦Ìg/ml), Listonella anguillarum 02-11 (MBC=1.0 ¦Ìg/ml), Yersinia ruckeri 96-4 (MBC=2.0 ¦Ìg/ml);##Gram-positive bacterium: Staphylococcus epidermis C621(MBC=8.5 ¦Ìg/ml);##Yeast: Candida albicans C627 (MBC=10.0 ¦Ìg/ml)."	[Ref.19330556] Non-hemolytic activity against rabbit red blood cells at concentrations 50-fold higher than its antimicrobial activity.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19330556	Mar Biotechnol (NY). 2009 Nov-Dec;11(6):748-757.	"Subramanian S, Ross NW, MacKinnon SL."	"Myxinidin, a novel antimicrobial peptide from the epidermal mucus of hagfish, Myxine glutinosa L."
DRAMP18253	KYYGNGLSXNKKGXTVDWGTAIGIIGNNAAANXATGGAAGXNK	43	Piscicocin CS526(Bacteriocin)	No entry found	Belongs to the class IIa bacteriocin	Not found	Carnobacterium piscicola CS526	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	"In this study, we found that piscicocin CS526, which possessed YGNGL sequence, had anti-Listeria activity typical of class IIa bacteriocins. Accordingly, the presence of Val7 within the YGNGV7 motif could not be a prerequisite for the antimicrobial activity of class IIa bacteriocins."	None	"The bacteriocin piscicocin CS526 was inactivated by proteolytic enzymes, was stable at 100 Celsius degree for 30 min, had a pH range of 2 to 8, and was active against Enterococcus, Listeria, Pediococcus, and Leuconostoc. "	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15640235##15836484	Appl Environ Microbiol. 2005 Jan;71(1):554-7.##J Appl Microbiol. 2005;98(5):1146-51.	"Yamazaki K, Suzuki M, Kawai Y, Inoue N, Montville TJ.##Suzuki M, Yamamoto T, Kawai Y, Inoue N, Yamazaki K."	"Purification and characterization of a novel class IIa bacteriocin, piscicocin CS526, from surimi-associated Carnobacterium piscicola CS526.##Mode of action of piscicocin CS526 produced by Carnobacterium piscicola CS526."
DRAMP02570	YRGGYTGPIPRPPPIGRPPLRLVVCACYRLSVSDARNCCIKFGSCCHLVK	50	"Penaeidin-1 (Pen-1; shrimps, Arthropods, animals)"	P81056	Belongs to the penaeidin family	Not found	Litopenaeus vannamei (Whiteleg shrimp)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of hemocytes and to a lesser extent in small granules of hemocytes.
Tissue specificity: Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain.
Developmental stage: Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours.
PTM: Contains three disulfide bonds 25-38; 27-45; 39-46."	"Gram-positive bacterium: Micrococcus luteus;##Gram-negative bacterium: Escherichia coli.##Fungi: Neurospora crassa, Fusarium oxysporum."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	9353298##10639333	Biol Chem. 1997 Nov 7;272(45):28398-28406.##J Cell Sci. 2000 Feb;113 (Pt 3):461-469.	"Destoumieux D, Bulet P, Loew D, Van Dorsselaer A, Rodriguez J, Bach¨¨re E.##Destoumieux D, Mu?oz M, Cosseau C, Rodriguez J, Bulet P, Comps M, Bach¨¨re E."	"Penaeidins, a new family of antimicrobial peptides isolated from the shrimp Penaeus vannamei (Decapoda).##Penaeidins, antimicrobial peptides with chitin-binding activity, are produced and stored in shrimp granulocytes and released after microbial challenge."
DRAMP02571	YRGGYTGPIPRPPPIGRPPFRPVCNACYRLSVSDARNCCIKFGSCCHLVK	50	"Penaeidin-2a (Pen-2a; shrimps, Arthropods, animals)"	P81057	Belongs to the penaeidin family	Not found	Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of hemocytes and to a lesser extent in small granules of hemocytes.
Tissue specificity: Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain.
Developmental stage: Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours.
PTM: Contains three disulfide bonds 24-38; 27-45; 39-46 and Lysine amide at position 50."	"Gram-positive bacterium: Micrococcus luteus;##Gram-negative bacterium: Escherichia coli.##Fungi: Neurospora crassa, Fusarium oxysporum, Saccharomyces cerevisiae TGY."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	11028917##9353298##10561573	Cell Mol Life Sci. 2000 Aug;57(8-9):1260-1271.##J Biol Chem. 1997 Nov 7;272(45):28398-28406.##Eur J Biochem. 1999 Dec;266(2):335-346.	"Destoumieux D, Munoz M, Bulet P, Bach¨¨re E.##Destoumieux D, Bulet P, Loew D, Van Dorsselaer A, Rodriguez J, Bach¨¨re E.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bach¨¨re E."	"Penaeidins, a family of antimicrobial peptides from penaeid shrimp (Crustacea, Decapoda).##Penaeidins, a new family of antimicrobial peptides isolated from the shrimp Penaeus vannamei (Decapoda).##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp."
DRAMP02575	QVYKGGYTRPVPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS	62	"Penaeidin-3b (Pen-3b; shrimps, Arthropods, animals)"	P81059	Belongs to the penaeidin family	Not found	Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity.
Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of hemocytes and to a lesser extent in small granules of hemocytes.
Tissue specificity: Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain.
Developmental stage: Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours.
PTM: Contains three disulfide bonds 32-47; 36-54; 48-55, Pyrrolidone carboxylic acid and Lysine amide at position 1 and 62 respectively."	"Gram-positive bacterium: Micrococcus luteus;##Gram-negative bacterium: Escherichia coli.##Fungi: Neurospora crassa, Fusarium oxysporum."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	11028917##10639333	Cell Mol Life Sci. 2000 Aug;57(8-9):1260-1271.##J Cell Sci. 2000 Feb;113 (Pt 3):461-469.	"Destoumieux D, Munoz M, Bulet P, Bach¨¨re E.##Destoumieux D, Mu?oz M, Cosseau C, Rodriguez J, Bulet P, Comps M, Bach¨¨re E."	"Penaeidins, a family of antimicrobial peptides from penaeid shrimp (Crustacea, Decapoda).##Penaeidins, antimicrobial peptides with chitin-binding activity, are produced and stored in shrimp granulocytes and released after microbial challenge."
DRAMP02576	QVYKGGYTRPIPRPPFVRPVPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS	61	"Penaeidin-3c (Pen-3c; shrimps, Arthropods, animals)"	P81060	Belongs to the penaeidin family	Not found	Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity.
Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of hemocytes and to a lesser extent in small granules of hemocytes.
Tissue specificity: Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain.
Developmental stage: Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours.
PTM: Contains three disulfide bonds 31-46; 35-53; 47-54, Pyrrolidone carboxylic acid and Lysine amide at position 1 and 62 respectively."	"Gram-positive bacterium: Micrococcus luteus;##Gram-negative bacterium: Escherichia coli.##Fungi: Neurospora crassa, Fusarium oxysporum."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	11028917##10639333	Cell Mol Life Sci. 2000 Aug;57(8-9):1260-1271.##J Cell Sci. 2000 Feb;113 (Pt 3):461-469.	"Destoumieux D, Munoz M, Bulet P, Bach¨¨re E.##Destoumieux D, Mu?oz M, Cosseau C, Rodriguez J, Bulet P, Comps M, Bach¨¨re E."	"Penaeidins, a family of antimicrobial peptides from penaeid shrimp (Crustacea, Decapoda).##Penaeidins, antimicrobial peptides with chitin-binding activity, are produced and stored in shrimp granulocytes and released after microbial challenge."
DRAMP02602	FLRFIGSVIHGIGHLVHHIGVAL	23	"Clavaspirin (chordates, animals)"	O97395	Not found	Not found	Styela clava (Sea squirt)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Alpha helix 	Not found	None	Function: Has potent hemolytic activity. 	[Swiss_Prot Entry O97395]Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria	[Ref.12005415]has potent hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12005415	J Pept Res. 2001 Dec;58(6):445-456.	"Lee IH, Zhao C, Nguyen T, Menzel L, Waring AJ, Sherman MA, Lehrer RI."	"Clavaspirin, an antibacterial and haemolytic peptide from Styela clava."
DRAMP18250	MACQCPDAISGWTHTDYQCHGLENKMYRHVYAICMNGTQVYCRTEWGSSC	50	Laterosporulin (Bacteriocin)	H1ZZ98	Belongs to the class IId bacteriocin	laterosporulin	Brevibacillus sp. Strain GI-9	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Beta strand	"The crystal structure of LS at 2.0 A resolution reveals an all-bconformation of this peptide, with four beta-strands forming a twisted b-sheet. All six intrinsic cysteines are intramolecularly disulfide-bonded, with two disulfides constraining the N terminus of the peptide and the third disulfide crosslinking the extreme C terminus, resulting in the formation of a closed structure. Despite a low overall sequence similarity, LS has disul"	4OZK resolved by X-ray	"This peptide is thermal stable, pH tolerant, and resistant to proteases. Reducing agent DTT had no effect on peptide activity or migration on gel."	"Gram-positive, Gram-negative (broad spectrum)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22403615##25345978	PLoS One. 2012;7(3):e31498. doi: 10.1371/journal.pone.0031498.##FEBS J. 2015 Jan;282(2):203-14.	"Singh PK, Chittpurna, Ashish, Sharma V, Patil PB, Korpole S.##Singh PK, Solanki V, Sharma S, Thakur KG, Krishnan B, Korpole S."	"Identification, purification and characterization of laterosporulin, a novel bacteriocin produced by Brevibacillus sp. strain GI-9.##The intramolecular disulfide-stapled structure of laterosporulin, a class IId bacteriocin, conceals a human defensin-like structural module."
DRAMP18248	KYGDVPLY	8	Bifidin I(Bacteriocin)	No entry found	Belongs to the class IIa bacteriocin	Not found	Bifidobacterium infantis BCRC 14602	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	The N-terminal sequencing may also be blocked partially or totally which could be due to the structure of the peptide (circular) or N terminal capping.	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Food Control. 2010 May;21(5):746-753.	"Cheikhyoussef A,Cheikhyoussef N,Chen HQ,Zhao JX,Tang J,Zhang H,Chen W."	Bifidin I - A new bacteriocin produced by Bifidobacterium infantis BCRC 14602: Purification and partial amino acid sequence
DRAMP18249	DWTFANWSCLVCDDCSVNLTV	21	Bac-GM100  (Bacteriocin)	No entry found	Belongs to the class IId bacteriocin	Not found	Brevibacillus brevis strain GM100	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	The 21 N-terminal residues of Bac-GM100 displayed 65% homology with thurincin H from Bacillus thuringiensis. Bac-GM100 was extremely heat-stable and was stable within a pH range of 3-10. It proved sensitive to various proteases.	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23291759	Biosci Biotechnol Biochem. 2013;77(1):151-60.	"Ghadbane M, Harzallah D, Laribi AI, Jaouadi B, Belhadj H."	Purification and biochemical characterization of a highly thermostable bacteriocin isolated from Brevibacillus brevis strain GM100.
DRAMP18247	DWTXWSXL	8	Bacthuricin F4(Bacteriocin)	No entry found	Belongs to the class IId bacteriocin	Not found	Bacillus thuringiensis subsp. kurstaki strain BUPM4	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	No proteins were shown to have similar sequences in either their N-terminal regions or any other region.	None	This bacteriocin was heat-stable up to 70 degrees C and resisted up to pH 3.0. Bacthuricin F4 was sensitive to proteases demonstrating its proteinaceous nature. 	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15752334	J Appl Microbiol. 2005;98(4):881-8.	"Kamoun F, Mejdoub H, Aouissaoui H, Reinbolt J, Hammami A, Jaoua S."	"Purification, amino acid sequence and characterization of Bacthuricin F4, a new bacteriocin produced by Bacillus thuringiensis."
DRAMP02642	GFCRCLCRRGVCRCICTR	18	"Rhesus theta-defensin 1 (RTD-1; primates, mammals, animals)"	"P82271, P82270, Q9TU01"	Belongs to the alpha-defensin family (Theta subfamily)	Not found	Macaca mulatta (Rhesus macaque)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Protein level	Beta strand (4 strands; 10 residues)	Not found	1HVZ resolved by NMR.	"Function: RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S. aureus 502A and L. monocytogenes, the Gram-negative bacterium S. typhimurium, and the fungi C. albicans 16820 and C. neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E. coli ML35.
Subunit structure: RTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked.
Tissue specificity: RTD-1 is expressed in bone marrow. Detected in promyelocytes, myelocytes and mature neutrophils and monocytes.
Developmental stage: RTD-1 expression begins early during granulocyte myelopoiesis.
PTM: Forms a cyclic peptide with 1 subunit B (RTD-2) or with 1 subunit A (RTD-1). An additional intersubunit disulfide bond is formed.
Miscellaneous: RTD-1 is 10-fold more present in cells than RTD-2."	"Gram-positive bacteria: Staphylococcus aureus 502a and Listeria monocytogenes;##Gram-negative bacteria: Salmonella typhimurium, Escherichia coli ML35.##Fungi: Candida albicans 16820, Cryptococcus neoformans 271A (the activity of RTD-2 against Escherichia coli ML35 was 2-3-fold less than those of RTD-1 and RTD-3)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12."	L	No cytotoxicity information found	Not found	10521339##1152799##11675394	Science. 1999 Oct 15;286(5439):498-502.##J Leukoc Biol. 2001 Sep;70(3):461-464.##J Biol Chem. 2002 Feb 1;277(5):3079-3084.	"Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME.##Leonova L, Kokryakov VN, Aleshina G, Hong T, Nguyen T, Zhao C, Waring AJ, Lehrer RI.##Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME."	"A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.##Circular minidefensins and posttranslational generation of molecular diversity.##Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides."
DRAMP02643	RCLCRRGVCRCLCRRGVC	18	"Rhesus theta-defensin 2 (RTD-2; primates, mammals, animals)"	P82271	Belongs to the alpha-defensin family (Theta subfamily)	Not found	Macaca mulatta (Rhesus macaque)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S. aureus 502A and L. monocytogenes, the Gram-negative bacterium S. typhimurium, and the fungi C. albicans 16820 and C. neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E. coli ML35.
Subunit structure: RTD-2 is a cyclic homodimer composed of two subunits B; disulfide-linked.
PTM: Forms a cyclic peptide with 1 subunit B (RTD-2) or with 1 subunit A (RTD-1). An additional intersubunit disulfide bond is formed.
Miscellaneous: RTD-1 is 10-fold more present in cells than RTD-2."	"Gram-positive bacteria: Staphylococcus aureus 502a, Listeria monocytogenes; ##Gram-negative bacteria: Salmonella typhimurium, Escherichia coli ML35.##Fungi: Candida albicans 16820, Cryptococcus neoformans 271A (the activity of RTD-2 against Escherichia coli ML35 was 2-3-fold less than those of RTD-1 and RTD-3)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10521339##1152799##11675394	Science. 1999 Oct 15;286(5439):498-502.##J Leukoc Biol. 2001 Sep;70(3):461-464.##J Biol Chem. 2002 Feb 1;277(5):3079-3084.	"Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME.##Leonova L, Kokryakov VN, Aleshina G, Hong T, Nguyen T, Zhao C, Waring AJ, Lehrer RI.##Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME."	"A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.##Circular minidefensins and posttranslational generation of molecular diversity.##Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides."
DRAMP02644	RCICTRGFCRCICTRGFC	18	"Rhesus theta-defensin 3 (RTD-3; primates, mammals, animals)"	"P82270, Q9TU01"	Belongs to the alpha-defensin family (Theta subfamily)	Not found	Macaca mulatta (Rhesus macaque)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Protein level	Bridge	Not found	None	"Function: RTD-1 and RTD-3 have similar antimicrobial activities against the Gram-positive bacteria, the Gram-negative bacteria and the fungi C. albicans 16820 and C. neoformans 271A.
Subunit structure RTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked. RTD-3 is a cyclic homodimer composed of two subunits A; disulfide-linked.
PTM: Forms a cyclic peptide with subunit A (RTD-3) or with subunit B (RTD-1). An additional intersubunit disulfide bond is formed.
Miscellaneous: RTD-1 is 10-fold more present in cells than RTD-3."	"Gram-positive bacteria: Staphylococcus aureus 502a, Listeria monocytogenes;##Gram-negative bacteria: Salmonella typhimurium, Escherichia coli ML35.##Fungi: Candida albicans 16820, Cryptococcus neoformans 271A (the activity of RTD-2 against Escherichia coli ML35 was 2-3-fold less than those of RTD-1 and RTD-3)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10521339##1152799##11675394	Science. 1999 Oct 15;286(5439):498-502.##J Leukoc Biol. 2001 Sep;70(3):461-464.##J Biol Chem. 2002 Feb 1;277(5):3079-3084.	"Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME.##Leonova L, Kokryakov VN, Aleshina G, Hong T, Nguyen T, Zhao C, Waring AJ, Lehrer RI.##Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME."	"A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.##Circular minidefensins and posttranslational generation of molecular diversity.##Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides."
DRAMP02653	ACYCRIPACLAGERRYGTCFYLGRVWAFCC	30	"Neutrophil defensin 1 (RMAD-1; primates, mammals, animals)"	P60030	Belongs to the alpha-defensin family	Not found	Macaca mulatta (Rhesus macaque) 	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	Function: Has antibacterial and antifungal activiy. 	Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;##Gram-negative bacterium: Escherichia coli.##Fungi: Cryptococcus neoformans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10531277	Infect Immun. 1999 Nov;67(11):6139-6144.	"Tang YQ, Yuan J, Miller CJ, Selsted ME."	"Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes."
DRAMP02654	ACYCRIPACLAGERRYGTCFYMGRVWAFCC	30	"Neutrophil defensin 2 (RMAD-2; primates, mammals, animals)"	P82317	Belongs to the alpha-defensin family	Not found	Macaca mulatta (Rhesus macaque) 	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	Function: Has antibacterial and antifungal activiy. 	Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;##Gram-negative bacterium: Escherichia coli.##Fungi: Cryptococcus neoformans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10531277	Infect Immun. 1999 Nov;67(11):6139-6144.	"Tang YQ, Yuan J, Miller CJ, Selsted ME."	"Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes."
DRAMP02659	ACYCRIPACLAGERRYGTCFYRRRVWAFCC	30	"Neutrophil defensin 3 (RMAD-3; primates, mammals, animals)"	"P60031, P82318"	Belongs to the alpha-defensin family	Not found	Macaca mulatta (Rhesus monkey)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bacteriostatic and antifungal activity.
PTM: Contains three disulfide bonds: 2-30; 4-19; 9-29."	Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;##Gram-negative bacteria: Escherichia coli.##Fungi: Cryptococcus neoformans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10531277	Infect Immun. 1999 Nov;67(11):6139-6144.	"Tang YQ, Yuan J, Miller CJ, Selsted ME."	"Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes."
DRAMP02660	RRTCRCRFGRCFRRESYSGSCNINGRIFSLCCR	33	"Neutrophil defensin 4 (RMAD-4; primates, mammals, animals)"	P82319	Belongs to the alpha-defensin family	Not found	Macaca mulatta (Rhesus monkey)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Defensins 4 has bacteriostatic and antifungal activity.
PTM: Contains three disulfide bonds 4-32; 6-21; 11-31."	Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;##Gram-negative bacteria: Escherichia coli.##Fungi: Cryptococcus neoformans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10531277	Infect Immun. 1999 Nov;67(11):6139-6144.	"Tang YQ, Yuan J, Miller CJ, Selsted ME."	"Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes."
DRAMP02661	RTCRCRFGRCFRRESYSGSCNINGRIFSLCCR	32	"Neutrophil defensin 5 (RMAD-5; primates, mammals, animals)"	P82319	Belongs to the alpha-defensin family	Not found	Macaca mulatta (Rhesus monkey)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Defensins 5 has bacteriostatic and antifungal activity.
PTM: Contains three disulfide bonds 3-31; 5-20; 10-30."	Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;##Gram-negative bacteria: Escherichia coli.##Fungi: Cryptococcus neoformans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10531277	Infect Immun. 1999 Nov;67(11):6139-6144.	"Tang YQ, Yuan J, Miller CJ, Selsted ME."	"Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes."
DRAMP02662	RRTCRCRFGRCFRRESYSGSCNINGRISSLCCR	33	"Neutrophil defensin 6 (RMAD-6; primates, mammals, animals)"	P82320	Belongs to the alpha-defensin family	Not found	Macaca mulatta (Rhesus monkey)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Defensins 6 has bacteriostatic and antifungal activity.
PTM: Contains three disulfide bonds 65-93; 67-82; 72-92."	Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;##Gram-negative bacteria: Escherichia coli.##Fungi: Cryptococcus neoformans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10531277	Infect Immun. 1999 Nov;67(11):6139-6144.	"Tang YQ, Yuan J, Miller CJ, Selsted ME."	"Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes."
DRAMP02663	RTCRCRFGRCFRRESYSGSCNINGRISSLCCR	32	"Neutrophil defensin 7 (RMAD-7; primates, mammals, animals)"	P82320	Belongs to the alpha-defensin family	Not found	Macaca mulatta (Rhesus monkey)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge 	Not found	None	"Function: Defensins 7 has bacteriostatic and antifungal activity.
PTM: Contains three disulfide bonds 65-93; 67-82; 72-93."	Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes;##Gram-negative bacteria: Escherichia coli.##Fungi: Cryptococcus neoformans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10531277	Infect Immun. 1999 Nov;67(11):6139-6144.	"Tang YQ, Yuan J, Miller CJ, Selsted ME."	"Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes."
DRAMP02698	RRTCHCRSRCLRRESNSGSCNINGRIFSLCCR	32	"Rhesus macaque oral alpha-defensins (ROADs; primates, mammals, animals)"	B5AKV3	Belongs to the alpha-defensin family	Not found	Macaca mulatta (Rhesus monkey)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand (3 strands; 19 residues)	NMR spectroscopy shows that Synthetic ROAD-1 adopts the canonical disulfide pairing and alpha-defensin fold.	2K1I resolved by NMR.	"Function: ROAD-1 is active against Staphylococcus aureus, Escherichia coli, and Candida albicans in a concentration-dependent manner. The antimicrobial mechanism of defensins has been correlated with their ability to disrupt and permeabilize the cell envelope, activities that depend on the surface features of the folded peptide.
PTM: Contains three disulfide bonds."	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli.##Fungi: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bonds between Cys4 and Cys31; Cys6 and Cys20; Cys10 and Cys30.	L	No cytotoxicity information found	Not found	18930922	J Biol Chem. 2008 Dec 19;283(51):35869-35877.	"Vasudevan S, Yuan J, Osapay G, Tran P, Tai K, Liang W, Kumar V, Selsted ME, Cocco MJ."	"Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque."
DRAMP18242	EKYTEVPEYV	10	Fengycin B2 (Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus thuringiensis 	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	K2 is Orn. The C-terminal V forms an ester bond with the side chain of Y3.	None	Fuction: Active against fungi C. Albicans and A.niger. 	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	24312083##22847390 	Front Microbiol. 2013 Nov 21;4:332.##J Am Soc Mass Spectrom. 2012 Oct;23(10):1716-28. Epub 2012 Jul 31. 	"Roy A, Mahata D, Paul D, Korpole S, Franco OL, Mandal SM.##Pathak KV, Keharia H, Gupta K, Thakur SS, Balaram P."	"Purification, biochemical characterization and self-assembled structure of a fengycin-like antifungal peptide from Bacillus thuringiensis strain SM1.##Lipopeptides from the banyan endophyte, Bacillus subtilis K1: mass spectrometric characterization of a library of fengycins."
DRAMP18240	EKYTEIPEYV	10	Fengycin C(Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis K1	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	K2 is Orn.	None	Comment: No comments found on DRAMP database	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22847390	J Am Soc Mass Spectrom. 2012 Oct;23(10):1716-28. Epub 2012 Jul 31.	"Pathak KV, Keharia H, Gupta K, Thakur SS, Balaram P."	"Lipopeptides from the banyan endophyte, Bacillus subtilis K1: mass spectrometric characterization of a library of fengycins."
DRAMP18241	TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCN	32	Subtilomycin(Bacteriocin)	No entry found	Belongs to the lantibiotics family (Class I bacteriocin)	subA	Bacillus subtilis MMA7 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	"There are extensive post-translational modifications: T1, T4 and T8 are dehydrated into Dhb. The N-terminal Dhb was unstable and further oxidized by deamination into 2-oxo butyrate. In addition, thioether or methylthioether bonds occur between the following residue pairs: S11-C15, T17-C21, T20-C23, S24-C28, and S27-C31."	None	"Therefore the most likely sequence for the lantibiotic is Dhb*-W-A-Dhb-I-G-K-Dhb-I-V-Q-Dha-V-K-K-C-R-Dhb-F-Dhb-C-G-C-Dha-L-G-Dha-C-Dha-N-C-N, where the underlined amino acids have been experimentally confirmed by mass spectrometric analysis and the subsequent sequence predicted from the genomic sequence of strain MMA7."	"Gram-positive, Gram-negative (broad spectrum)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23736764	Mar Drugs. 2013 Jun 3;11(6):1878-98.	"Phelan RW, Barret M, Cotter PD, O'Connor PM, Chen R, Morrissey JP, Dobson AD, O'Gara F, Barbosa TM."	Subtilomycin: a new lantibiotic from Bacillus subtilis strain MMA7 isolated from the marine sponge Haliclona simulans.
DRAMP18239	EKYTEAPEYV	10	Fengycin A2(Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis K1	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	K2 is Orn. The C-terminal V forms an ester bond with the side chain of Y3.	None	Comment: No comments found on DRAMP database	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22847390	J Am Soc Mass Spectrom. 2012 Oct;23(10):1716-28. Epub 2012 Jul 31.	"Pathak KV, Keharia H, Gupta K, Thakur SS, Balaram P."	"Lipopeptides from the banyan endophyte, Bacillus subtilis K1: mass spectrometric characterization of a library of fengycins."
DRAMP18238	EKYTEVPEYI	10	Fengycin B(Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis K1	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	K2 is Orn. The structure consists of a cyclic peptide lactone formed between the phenolic -OH of Tyr3 and the C-terminal -COOH of an amino acid at position 10. The N-terminus of the decapeptide segment is acylated with a beta-hydroxy fatty acid (beta-OH FA).	None	Comment: No comments found on DRAMP database	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22847390	J Am Soc Mass Spectrom. 2012 Oct;23(10):1716-28. Epub 2012 Jul 31.	"Pathak KV, Keharia H, Gupta K, Thakur SS, Balaram P."	"Lipopeptides from the banyan endophyte, Bacillus subtilis K1: mass spectrometric characterization of a library of fengycins."
DRAMP18237	EKYTEAPEYI	10	Fengycin A(Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis K1	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	K2 is Orn. The structure consists of a cyclic peptide lactone formed between the phenolic -OH of Tyr3 and the C-terminal -COOH of an amino acid at position 10. The N-terminus of the decapeptide segment is acylated with a beta-hydroxy fatty acid (beta-OH FA).	None	Comment: No comments found on DRAMP database	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22847390	J Am Soc Mass Spectrom. 2012 Oct;23(10):1716-28. Epub 2012 Jul 31.	"Pathak KV, Keharia H, Gupta K, Thakur SS, Balaram P."	"Lipopeptides from the banyan endophyte, Bacillus subtilis K1: mass spectrometric characterization of a library of fengycins."
DRAMP02739	EKKCPGRCTLKCGKHERPTLPYNCGKYICCVPVKVK	36	"TEWP (turtle egg-white protein; Reptiles, animals)"	No entry found	Not found	Not found	Caretta caretta (Loggerhead turtle)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Not found	Beta strand (2 strands; 2 residues)	The protein has no ¦Á-helix and consists of two antiparallel ¦Â-sheets. 	2B5B resolved by NMR.	"Function: The protein showes strong antibacterial activity against Escherichia coli and Salmonella typhimurium. The protein also showes significant antiviral activity against an enveloped rhabdovirus, Chandipura virus,"	"Gram-negative bacteria: Escherichia coli (IC50=2.3 ?M), Salmonella typhimurium (IC50=2.8 ?M);##Gram-positive bacterium: Staphylococcus aureus (IC50=5.1 ?M).##Virus: enveloped rhabdovirus, Chandipura virus, Vesicular stomatitis virus."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16700051	Proteins. 2006 Aug 1;64(2):524-531.	"Chattopadhyay S, Sinha NK, Banerjee S, Roy D, Chattopadhyay D, Roy S."	Small cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity.
DRAMP02741	DDTPSSRCGSGGWGPCLPIVDLLCIVHVTVGCSGGFGCCRIG	42	"Pelovaterin (defensin-like AMP; Gly-rich; Reptiles, animals)"	P84818	Not found	Not found	Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	"An analysis of the ensemble of pelovaterin structures reveals that hydrophilic residues Asp1 Arg7 begin with a random coil structure leading to a short 310 helix between Cys8 and Gly12, whereas antiparallel ?-strands are formed by the residues Leu17 Val20 (¦Â), His27 Val28 (?2), and Gly34 Cys39 (?3) arranged in a ¦Â?2?3 topology. "	2JR3 resolved by NMR.	"Function: Induces the nucleation and stabilization of vaterite, one of the crystalline polymorphs of calcium carbonate. Exhibits strong antimicrobial activity against Pseudomonas aeruginosa and Proteus vulgaris.
PTM: Contains three disulfide bonds 8-38; 16-32; 24-39."	"Gram-negative bacteria: Pseudomonas aeruginosa (EC50=0.42 ?g/mL), Proteus vulgaris (EC50=0.37 ?g/mL), Proteus mirabilis (EC50=8.4 ?g/mL);##Gram-positive bacterium: Staphylococcus aureus (EC50=42 ?g/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15877362##18341335	Biomacromolecules. 2005 May-Jun;6(3):1429-37.##J Am Chem Soc. 2008 Apr 9;130(14):4660-8.	"Lakshminarayanan R, Chi-Jin EO, Loh XJ, Kini RM, Valiyaveettil S.##minarayanan R, Vivekanandan S, Samy RP, Banerjee Y, Chi-Jin EO, Teo KW, Jois SD, Kini RM, Valiyaveettil S."	"Purification and characterization of a vaterite-inducing peptide, pelovaterin, from the eggshells of Pelodiscus sinensis (Chinese soft-shelled turtle).##Structure, self-assembly, and dual role of a beta-defensin-like peptide from the Chinese soft-shelled turtle eggshell matrix."
DRAMP02742	QKKCPGRCTLKCGKHERPTLPYNCGKYICCVPVKVK	36	"Defensin-like turtle egg white protein TEWP (TEWP; Reptiles, animals)"	P0CAP0	Belongs to the beta-defensin family	Not found	Caretta caretta (Loggerhead sea turtle)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Protein level	Beta strand (2 strands; 2 residues)	Three-dimensional structure of TEWP was determined by distance geometry and simulated annealing. The protein has no ¦Á-helix and consists of two antiparallel ¦Â-sheets. The secondary structure is consistent with the previously obtained circular dichroism spectra. 	2B5B resolved by NMR.	"Function: The protein showes strong antibacterial activity against Escherichia coli and Salmonella typhimurium and also showes significant antiviral activity against an enveloped rhabdovirus, Chandipura virus, which is an emerging human pathogen.
Tissue specificity: Detected in egg white (at protein level)."	"Gram-negative bacteria: Escherichia coli (IC50=3.3 ?M), Salmonella typhimurium (IC50=2.8 ?M);##Gram-positive bacterium: Staphylococcus aureus (IC50=5. 1?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16700051	Proteins. 2006 Aug 1;64(2):524-531.	"Chattopadhyay S, Sinha NK, Banerjee S, Roy D, Chattopadhyay D, Roy S."	Small cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity.
DRAMP03743	RSVCRQIKICRRRGGCYYKCTNRPY	25	"Androctonin (Arthropods, animals)"	P56684	Not found	Not found	Androctonus australis (Sahara scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand (2 strands; 8 residues)	The structure of androctonin involves a well-defined highly twisted anti-parallel beta-sheet with strands connected by a more variable positively charged turn.	1CZ6 resolved by NMR.	"Function: Androctonin is a highly cationic antimicrobial peptide from scorpion exhibiting a broad spectrum of activities against bacteria (Gram-positive and Gram-negative) and filamentous fungi. Acts on the membrane of the bacterial cells. It destabilize a membrane by modifying its properties.
PTM: Contains two disulfide bonds 4-20; 10-16."	"[Ref.10942757] Gram-positive bacteria: Micrococcus luteus (MIC=0.6-1.5 ¦ÌM), Aerococcus viridans (MIC=0.3-0.6 ¦ÌM), Staphylococcus aureus (MIC=15-30 ¦ÌM);##Gram-negative bacteria: Escherichia coli D31 (MIC=3-6 ¦ÌM),  Escherichia coli D22 (MIC=6-15 ¦ÌM),  Escherichia coli 1106 (MIC=6-15 ¦ÌM), Salmonella typhimurium (MIC=3-6 ¦ÌM).##Fungi: Alternaria brassicola (MIC=3-6 ¦ÌM), Fusarium culmorum (MIC=3-6 ¦ÌM), Fusarium oxysporum (MIC=6-12 ¦ÌM), Neurospora crassa (MIC=6-12 ¦ÌM), Nectria haematococca (MIC=6-12 ¦ÌM), Trichoderma viridae (MIC=6-12 ¦ÌM);##Yeast: Candida albicans (MIC=1.6-3.15 ¦ÌM).##[Ref.8939880] Gram-positive bacteria: Bacillus subtilis (MIC=1.5-3.0 ¦ÌM);##Gram-negative bacteria: Escherichia coli D22 (MIC>30 ¦ÌM), Pseudomonas syringae (MIC=1.5-3.0 ¦ÌM), Pseudomonas syringae pv.syringae (MIC=15-22 ¦ÌM), Pseudomonas syringae phaseoli (MIC=1.5-3.0 ¦ÌM), Pseudomonas syringae pv.pisi (MIC=6-15 ¦ÌM), Pseudomonas syringae pv. maculicola (MIC=3-6 ¦ÌM), Phoma valerianella (MIC=15-22 ¦ÌM), Xanthomonas compestris pv.compestris (MIC=3-6 ¦ÌM), Xanthomonas vesicatoria 687.3 (MIC=1.5-3.0 ¦ÌM), Xanthomonas vesicatoria B229RI (MIC=1.5-3.0 ¦ÌM);##Fungi: Alternaria dauci (MIC=8-16 ¦ÌM), Stemphylium (MIC=4-8 ¦ÌM),  Fusarium oxysporum M. (MIC=2-4 ¦ÌM), Fusarium oxysporum L. (MIC=2-4 ¦ÌM), Botrytis cinerea (MIC=6-12 ¦ÌM), B. petunia (MIC=4-8 ¦ÌM), Verticilium toreilis (MIC=2-4 ¦ÌM), Aspergillus fumigatus (MIC=25-50 ¦ÌM)."	[Ref.8939880] It exhibits no hemolytic activity on porcine or bovine erythrocytes at a concentration of up to 150 ¦ÌM.	Cyclic	Free	Free	"Disulfide bond between Cys4 and Cys20,Cys10 and Cys16."	L	No cytotoxicity information found	Cell membrane	8939880##10563585##10942757	J Biol Chem. 1996 Nov 22;271(47):29537-29544.##J Biomol Struct Dyn. 1999 Oct;17(2):367-380.##J Biol Chem. 2000 Oct 27;275(43):33464-70.	"Ehret-Sabatier L, Loew D, Goyffon M, Fehlbaum P, Hoffmann JA, van Dorsselaer A, Bulet P.##Mandard N, Sy D, Maufrais C, Bonmatin JM, Bulet P, Hetru C, Vovelle F.##Silva PI Jr, Daffre S, Bulet P."	"Characterization of novel cysteine-rich antimicrobial peptides from scorpion blood.##Androctonin, a novel antimicrobial peptide from scorpion Androctonus australis: solution structure and molecular dynamics simulations in the presence of a lipid monolayer.##Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family."
DRAMP02755	GWKDWLNKGKEWLKKKGPGIMKAALKAATQ	30	"Ponericin G3 (ants, insects, animals)"	P82416	Not found	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	MOA: The comparison of ponericins with those well-studied peptides suggests that ponericins may adopt an amphipathic alpha-helical structure on cell membranes.	"Gram-positive bacteria: Bacillus cereus CIP 6624a, B. megaterium ATCC 9885b, B. stearothermophilus CIP 675, B. stearothermophilus CIP 675, B. subtilis ATCC 6623, Enterococcus faecalis CIP 636, Lactococcus lactis ssp. cremoris I116, Streptococcus pyogenes CIP 561, S. sanguinis CIP 55128, Listeria ivanovii LMA 94d, Listeria monocytogenes ATCC 15313, Micrococcus luteus CIP 5345, Staphylococcus aureus CIP 677, Staphylococcus aureus LMA, S. epidermidis CIP 53134;##Gram-negative bacteria: Escherichia coli, Enterobacter cloacae CIP 6085, Klebsiella pneumoniae CIP 8291, Proteus mirabilis LMA TP, Salmonella enterica CIP 813, Serratia marcescens LMA TP, Alcaligenes faecalis CIP 6723, Pseudomonas aeruginosa CIP A22, Proteus mirabilis LMA TP, Flavobacterium meningosepticum CIP 6057, Pseudomonas aeruginosa CIP A22, Yersinia entericolitica CIP 6529, P. putida LMA, Saccharomyces cerevisiae LMA 720."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chafotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02756	DFKDWMKTAGEWLKKKGPGILKAAMAAAT	29	"Ponericin G4 (ants, insects, animals)"	P82417	Not found	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	MOA: The comparison of ponericins with those well-studied peptides suggests that ponericins may adopt an amphipathic alpha-helical structure on cell membranes.	"Gram-positive bacteria: B. cereus CIP 6624a, Bacillus megaterium ATCC 9885b, B.stearothermophilus CIP 675, B.stearothermophilus CIP 675, Bacillus subtilis ATCC 6623, Lactococcus lactis ssp. cremoris I116, Streptococcus pyogenes CIP 561, S. sanguinis CIP 55128, Micrococcus luteus CIP 5345;##Gram-negative bacteria: Klebsiella pneumoniae CIP 8291, Pseudomonas aeruginosa CIP A22, Saccharomyces cerevisae."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chafotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02758	GLVDVLGKVGGLIKKLLP	18	"Ponericin G6 (ants, insects, animals)"	P82419	Not found	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has activity against Gram-positive bacteria and S. cerevisiae. Has non-hemolytic activity.
Tissue specificity: Expressed by the venom gland."	"[Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a, B. megaterium ATCC 9885b, B. stearothermophilus CIP 675, B. stearothermophilus CIP 675, B. subtilis ATCC 6623, Lactococcus lactis ssp. cremoris I116, Streptococcus pyogenes CIP 561, S. sanguinis CIP 55128, Listeria monocytogenes ATCC 15313, Micrococcus luteus CIP 5345, Staphylococcus aureus CIP 677, S. epidermidis CIP 53134;##Gram-negative bacteria: Klebsiella pneumoniae CIP 8291, Pseudomonas aeruginosa CIP A22, Saccharomyces cerevisiae LMA 720."	[Ref.11279030]Non-hemolytic activity against horse and sheep erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chafotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02760	LLKELWTKMKGAGKAVLGKIKGLL	24	"Ponericin-L1 (ants, insects, animals)"	P82421	Not found	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the venom gland."	[Swiss_Prot Entry P82421]Broad spectrum of activity against both Gram-positive and Gram-negative bacteria	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02761	LLKELWTKIKGAGKAVLGKIKGLL	24	"Ponericin-L2 (ants, insects, animals)"	P82422	Not found	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral"	Protein level	Alpha helix 	Not found	None	"Function: Broad spectrum of activity against both Gram-positive and Gram-negative bacteria. 
Tissue specificity: Expressed by the venom gland."	"[Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 6.5mm), B. megaterium ATCC 9885b(Inhibition zone = 14mm), B. stearothermophilus CIP 675(Inhibition zone = 21mm), B. subtilis ATCC 6623(Inhibition zone = 13.5mm), Enterococcus faecalis CIP 636(Inhibition zone = 4mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 15.5mm), Streptococcus pyogenes CIP 561(Inhibition zone = 12.5mm), S. sanguinis CIP 55128(Inhibition zone = 6mm), Listeria ivanovii LMA 94d(Inhibition zone = 9.5mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 9.5mm), Micrococcus luteus CIP 5345(Inhibition zone = 10.5mm), Staphylococcus aureus CIP 677(Inhibition zone = 4.5mm), Staphylococcus aureus LMA(Inhibition zone = 11mm), S. epidermidis CIP 53134(Inhibition zone = 11.5mm);##Gram-negative bacteria: Escherichia coli(Inhibition zone = 4mm), Enterobacter cloacae CIP 6085(Inhibition zone = 5mm), Klebsiella pneumoniae CIP 8291(Inhibition zone = 3.5mm), Proteus mirabilis LMA TP(Inhibition zone = 9mm), Salmonella enterica CIP 813(Inhibition zone = 1.5mm), Serratia marcescens LMA TP(Inhibition zone = 9mm), Flavobacterium meningosepticum CIP 6057(Inhibition zone = 7mm), Pseudomonas aeruginosa CIP A22(Inhibition zone = 14mm)."	[Ref.11279030]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02762	WLGSALKIGAKLLPSVVGLFKKKKQ	25	"Ponericin-W1 (ants, insects, animals)"	P82423	Belongs to the ponericin-W family	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal, Antifungal"	Protein level	Not found	Not found	None	"Function: Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities. 
Tissue specificity: Expressed by the venom gland."	"[Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 10mm), B. megaterium ATCC 9885b(Inhibition zone = 12.5mm), B. stearothermophilus CIP 675(Inhibition zone = 17mm), B. subtilis ATCC 6623(Inhibition zone = 12mm), Enterococcus faecalis CIP 636(Inhibition zone = 6mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 15mm), Streptococcus pyogenes CIP 561(Inhibition zone = 10mm), S. sanguinis CIP 55128(Inhibition zone = 7.5mm), Listeria ivanovii LMA 94d(Inhibition zone = 11.5mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 9.5mm), Micrococcus luteus CIP 5345(Inhibition zone = 11.5mm), Staphylococcus aureus CIP 677(Inhibition zone = 10mm), Staphylococcus aureus LMA(Inhibition zone = 13.5mm), S. epidermidis CIP 53134(Inhibition zone = 13.5mm);##Gram-negative bacteria: Escherichia coli(Inhibition zone = 8mm), Enterobacter cloacae CIP 6085(Inhibition zone = 3mm), Klebsiella pneumoniae CIP 8291(Inhibition zone = 6.5mm), Proteus mirabilis LMA TP(no detected), Salmonella enterica CIP 813(Inhibition zone = 3mm), Serratia marcescens LMA TP(no detected), Flavobacterium meningosepticum CIP 6057(Inhibition zone = 6mm), Pseudomonas aeruginosa CIP A22(Inhibition zone = 16mm)."	[Ref.11279030]2mm in test condition against horse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 ¦Ìl of the peptide solution and placed overnight at 4¡æ to allow the diffusion of the hemolytic agent)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02764	GIWGTLAKIGIKAVPRVISMLKKKKQ	26	"Ponericin-W3 (ants, insects, animals)"	P82425	Not found	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal, Antifungal"	Protein level	Not found	Not found	None	"Function: Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities. 
Tissue specificity: Expressed by the venom gland."	"[Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 10mm), B. megaterium ATCC 9885b(Inhibition zone = 13.5mm), B. stearothermophilus CIP 675(Inhibition zone = 17mm), B. subtilis ATCC 6623(Inhibition zone = 13mm), Enterococcus faecalis CIP 636(Inhibition zone = 8mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 17.5mm), Streptococcus pyogenes CIP 561(Inhibition zone = 11.5mm), S. sanguinis CIP 55128(Inhibition zone = 10mm), Listeria ivanovii LMA 94d(Inhibition zone = 14mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 11mm), Micrococcus luteus CIP 5345(Inhibition zone = 11mm), Staphylococcus aureus CIP 677(Inhibition zone = 13mm), Staphylococcus aureus LMA(Inhibition zone = 18mm), S. epidermidis CIP 53134(Inhibition zone = 15mm);##Gram-negative bacteria: Escherichia coli(Inhibition zone = 10mm), Enterobacter cloacae CIP 6085(Inhibition zone = 4mm), Klebsiella pneumoniae CIP 8291(Inhibition zone = 7.5mm), Proteus mirabilis LMA TP(no detected), Salmonella enterica CIP 813(Inhibition zone = 4mm), Serratia marcescens LMA TP(Inhibition zone = 11mm), Flavobacterium meningosepticum CIP 6057(no detected), Pseudomonas aeruginosa CIP A22(Inhibition zone = 18.5mm)."	[Ref.11279030]1mm in test condition against horse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 ¦Ìl of the peptide solution and placed overnight at 4¡æ to allow the diffusion of the hemolytic agent)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02765	GIWGTALKWGVKLLPKLVGMAQTKKQ	26	"Ponericin-W4 (ants, insects, animals)"	P82426	Not found	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal, Antifungal"	Protein level	Not found	Not found	None	"Function: Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities. 
Tissue specificity: Expressed by the venom gland."	"[Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 8.5mm), B. megaterium ATCC 9885b(Inhibition zone = 13.5mm), B. stearothermophilus CIP 675(Inhibition zone = 18mm), B. subtilis ATCC 6623(Inhibition zone = 13mm), Enterococcus faecalis CIP 636(Inhibition zone = 3mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 14mm), Streptococcus pyogenes CIP 561(Inhibition zone = 8mm), S. sanguinis CIP 55128(Inhibition zone = 7mm), Listeria ivanovii LMA 94d(Inhibition zone = 10mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 10mm), Micrococcus luteus CIP 5345(Inhibition zone = 12.5mm), Staphylococcus aureus CIP 677(Inhibition zone = 11.5mm), Staphylococcus aureus LMA(Inhibition zone = 13.5mm), S. epidermidis CIP 53134(Inhibition zone = 11.5mm);##Gram-negative bacteria: Escherichia coli(Inhibition zone = 8.5mm), Enterobacter cloacae CIP 6085(Inhibition zone = 16.5mm), Klebsiella pneumoniae CIP 8291(Inhibition zone = 9mm), Proteus mirabilis LMA TP(no detected), Salmonella enterica CIP 813(no detected), Serratia marcescens LMA TP(Inhibition zone = 13mm), Flavobacterium meningosepticum CIP 6057(no detected), Pseudomonas aeruginosa CIP A22(Inhibition zone = 17mm)."	[Ref.11279030]2mm in test condition against horse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 ¦Ìl of the peptide solution and placed overnight at 4¡æ to allow the diffusion of the hemolytic agent)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02766	FWGALIKGAAKLIPSVVGLFKKKQ	24	"Ponericin-W5 (ants, insects, animals)"	P82427	Belongs to the ponericin-W family	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal, Antifungal"	Protein level	Not found	Not found	None	"Function: Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities. 
Tissue specificity: Expressed by the venom gland."	"[Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 7mm), B. megaterium ATCC 9885b(Inhibition zone = 12mm), B. stearothermophilus CIP 675(Inhibition zone = 17mm), B. subtilis ATCC 6623(Inhibition zone = 13mm), Enterococcus faecalis CIP 636(Inhibition zone = 3mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 11mm), Streptococcus pyogenes CIP 561(Inhibition zone = 6.5mm), S. sanguinis CIP 55128(Inhibition zone = 4.5mm), Listeria ivanovii LMA 94d(Inhibition zone = 8mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 6.5mm), Micrococcus luteus CIP 5345(Inhibition zone = 11mm), Staphylococcus aureus CIP 677(Inhibition zone = 7.5mm), Staphylococcus aureus LMA(Inhibition zone = 9mm), S. epidermidis CIP 53134(Inhibition zone = 7.5mm);##Gram-negative bacteria: Escherichia coli(Inhibition zone = 3mm), Enterobacter cloacae CIP 6085(Inhibition zone = 11mm), Klebsiella pneumoniae CIP 8291(Inhibition zone = 6.5mm), Proteus mirabilis LMA TP(no detected), Salmonella enterica CIP 813(no detected), Serratia marcescens LMA TP(Inhibition zone = 11mm), Flavobacterium meningosepticum CIP 6057(Inhibition zone = 5mm), Pseudomonas aeruginosa CIP A22(Inhibition zone = 14mm)."	[Ref.11279030]4mm in test condition against horse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 ¦Ìl of the peptide solution and placed overnight at 4¡æ to allow the diffusion of the hemolytic agent)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02767	FIGTALGIASAIPAIVKLFK	20	"Ponericin-W6 (ants, insects, animals)"	P82428	Not found	Not found	Pachycondyla goeldii (Ponerine ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Activity against Gram-positive bacteria. Has insecticidal and hemolytic activities.
Tissue specificity: Expressed by the venom gland."	"[Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 9.5mm), B. megaterium ATCC 9885b(Inhibition zone = 17mm), B. stearothermophilus CIP 675(Inhibition zone = 18mm), B. subtilis ATCC 6623(Inhibition zone = 15mm), Enterococcus faecalis CIP 636(Inhibition zone = 3mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 11mm), Streptococcus pyogenes CIP 561(Inhibition zone = 9.5mm), S. sanguinis CIP 55128(Inhibition zone = 4mm), Listeria ivanovii LMA 94d(Inhibition zone = 5mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 4mm), Micrococcus luteus CIP 5345(Inhibition zone = 11mm), Staphylococcus aureus CIP 677(Inhibition zone = 7mm), Staphylococcus aureus LMA(Inhibition zone = 10mm), S. epidermidis CIP 53134(Inhibition zone = 7mm);##Gram-negative bacteria: Serratia marcescens LMA TP(Inhibition zone = 13mm), Pseudomonas aeruginosa CIP A22(Inhibition zone = 14mm)."	[Ref.11279030]3mm in test condition against horse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 ¦Ìl of the peptide solution and placed overnight at 4¡æ to allow the diffusion of the hemolytic agent)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11279030	J. Biol. Chem. 2001; 276: 17823-17829.	"Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J."	"Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii."
DRAMP02770	IIGLVSKGTCVLVKTVCKKVLKQG	24	"Pilosulin 3 (ants, insects, animals)"	Q68Y23	Belongs to the pilosulin family	Not found	Myrmecia banksi (Jack jumper ant) (Australian jumper ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Shows moderate activity against E. coli and S. aureus (MIC<25 ?M), slight activity against B. subtilis (MIC<50 ?M), and no activity against L. garvieae, P. aeruginosa, C. albicans, and S. cerevisiae. Has no hemolytic nor cytolytic activity. Causes an IgE-independent histamine release. 
Tissue specificity: Expressed by the venom gland."	"[Ref.15246874]Gram-negative bacteria: Escherichia coli (MIC<25 ?M);##Gram-positive bacteria: Staphylococcus aureus(MIC<25 ?M), Bacillus subtilis (MIC<50 ?M)."	[Ref.15246874]Non-hemolytic activity at 50 ¦ÌM against human whole blood	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	IgE	15246874	Arch Biochem Biophys. 2004 Aug 15;428(2):170-178.	"Inagaki H, Akagi M, Imai HT, Taylor RW, Kubo T."	"Molecular cloning and biological characterization of novel antimicrobial peptides, pilosulin 3 and pilosulin 4, from a species of the Australian ant genus Myrmecia."
DRAMP02771	FDITKLNIKKLTKATCKVISKGASMCKVLFDKKKQE	36	"Pilosulin 4 (ants, insects, animals)"	Q68Y22	Belongs to the pilosulin family	Not found	Myrmecia banksi (Jack jumper ant) (Australian jumper ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Shows activity against E.coli and S.aureus, moderate activity against P.aeruginosa, weak activity against B.subtilis, and has no effect against L.garvieae, C.albicans, and S.cerevisiae. Has no hemolytic nor cytolytic activity. Causes an IgE-independent histamine release. 
Tissue specificity: Expressed by the venom gland."	"[Ref.15246874]Gram-positive bacteria: Staphylococcus aureus (MIC<6.25 ?M), Bacillus subtilis (MIC<50 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC<25 ?M), Escherichia coli (MIC<6.25 ?M)."	[Ref.15246874]Non-hemolytic activity at 50 ¦ÌM against human whole blood	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	 IgE 	15246874	Arch Biochem Biophys. 2004 Aug 15;428(2):170-178.	"Inagaki H, Akagi M, Imai HT, Taylor RW, Kubo T."	"Molecular cloning and biological characterization of novel antimicrobial peptides, pilosulin 3 and pilosulin 5, from a species of the Australian ant genus Myrmecia."
DRAMP02781	SLQGGAPNFPQPSQQNGGWQVSPDLGRDDKGNTRGQIEIQNKGKDHDFNAGWGKVIRGPNKAKPTWHVGGTYRR	74	"Coleoptericin (Insects, animals)"	P80032	Belongs to the coleoptericin family	Not found	Zophobas atratus (Giant mealworm beetle) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Responsible for the anti Gram-negative activity of immune hemolymph of Z. atratus.	"Gram-negative bacteria: Escherichia coli D31, E. coli D22 (highly activity), Acinetobacter baumannii, Pseudomonas maltophilia (lower activity);##Gram-positive bacterium: Micrococcus luteus."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1761552	J Biol Chem. 1991 Dec 25;266(36):24520-24525.	"Bulet P, Cociancich S, Dimarcq JL, Lambert J, Reichhart JM, Hoffmann D, Hetru C, Hoffmann JA."	Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.
DRAMP02783	FTCDVLGFEIAGTKLNSAACGAHCLALGRTGGYCNSKSVCVCR	43	"Peptide C (Insects, animals)"	No entry found	Not found	Not found	Zophobas atratus (Giant mealworm beetle) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli D22;##Gram-positive bacteria: Micrococcus luteus, Corynebacterium D2, Streptococcus pyogenes, Bacillus subtilis QB935."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	1761552	J Biol Chem. 1991 Dec 25;266(36):24520-24525.	"Bulet P, Cociancich S, Dimarcq JL, Lambert J, Reichhart JM, Hoffmann D, Hetru C, Hoffmann JA."	Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.
DRAMP02784	SLQPGAPNVNNKDQPWQVSPHISRDDSGNTRTDINVQRHGENNDFEAGWSKVVRGPNKAKPTWHIGGTHRW	71	"Acaloleptin-A1 (chain of Acaloleptin A; Insects, animals)"	"P81592, Q76K70"	Belongs to the coleoptericin family	Not found	Acalolepta luxuriosa (Udo longhorn beetle)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Acaloleptins A1 show antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria.
Tissue specificity: Hemolymph (at protein level). Larval fat body.
Induction: By bacterial infection. Expression detected 2 hours post-injection, with expression increasing until 48 hours post-injection and remaining considerably high at least until 72 hours post-injection."	"Gram-negative bacteria: Escherichia coli, Aeromonas hydrophila, Erwinia persicinus, Serratia marcescens, Aeromonas hydrophila. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10077828##19527748	Arch Insect Biochem Physiol. 1999;40(2):88-98.##Dev Comp Immunol. 2009 Oct;33(10):1120-1127. 	"Imamura M, Wada S, Koizumi N, Kadotani T, Yaoi K, Sato R, Iwahana H.##Imamura M, Wada S, Ueda K, Saito A, Koizumi N, Iwahana H, Sato R."	"Acaloleptins A: inducible antibacterial peptides from larvae of the beetle, Acalolepta luxuriosa.##Multipeptide precursor structure of acaloleptin A isoforms, antibacterial peptides from the Udo longicorn beetle, Acalolepta luxuriosa."
DRAMP02785	SLQPGAPNINNKDQPWQVSPHISRDDNGNTRTNINVQRHGENNDFEAGWSKVVRGPNKAKPTWHIGGTHRW	71	"Acaloleptin-A2 (chain of Acaloleptin A; Insects, animals)"	"P81592, Q76K70"	Belongs to the coleoptericin family	Not found	Acalolepta luxuriosa (Udo longhorn beetle)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Acaloleptins A2 show antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria.
Induction: By bacterial infection. Expression detected 2 hours post-injection, with expression increasing until 48 hours post-injection and remaining considerably high at least until 72 hours post-injection."	"Gram-negative bacteria: Escherichia coli, Aeromonas hydrophila, Erwinia persicinus, Serratia marcescens, Aeromonas hydrophila. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10077828##19527748	Arch Insect Biochem Physiol. 1999;40(2):88-98.##Dev Comp Immunol. 2009 Oct;33(10):1120-1127. 	"Imamura M, Wada S, Koizumi N, Kadotani T, Yaoi K, Sato R, Iwahana H.##Imamura M, Wada S, Ueda K, Saito A, Koizumi N, Iwahana H, Sato R."	"Acaloleptins A: inducible antibacterial peptides from larvae of the beetle, Acalolepta luxuriosa.##Multipeptide precursor structure of acaloleptin A isoforms, antibacterial peptides from the Udo longicorn beetle, Acalolepta luxuriosa."
DRAMP02786	SLQPGAPNVNNKDQPWQVSPHISRDDSGNTRTNINVQRHGENNDFEAGWSKVVRGPNKAKPTWHIGGTHRW	71	"Acaloleptin-A3 (chain of Acaloleptin A; Insects, animals)"	"P81592, Q76K70"	Belongs to the coleoptericin family	Not found	Acalolepta luxuriosa (Udo longhorn beetle)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Acaloleptins A3 show antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria.
Induction: By bacterial infection. Expression detected 2 hours post-injection, with expression increasing until 48 hours post-injection and remaining considerably high at least until 72 hours post-injection."	"Gram-negative bacteria: Escherichia coli, Aeromonas hydrophila, Erwinia persicinus, Serratia marcescens, Aeromonas hydrophila. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10077828##19527748	Arch Insect Biochem Physiol. 1999;40(2):88-98.##Dev Comp Immunol. 2009 Oct;33(10):1120-1127. 	"Imamura M, Wada S, Koizumi N, Kadotani T, Yaoi K, Sato R, Iwahana H.##Imamura M, Wada S, Ueda K, Saito A, Koizumi N, Iwahana H, Sato R."	"Acaloleptins A: inducible antibacterial peptides from larvae of the beetle, Acalolepta luxuriosa.##Multipeptide precursor structure of acaloleptin A isoforms, antibacterial peptides from the Udo longicorn beetle, Acalolepta luxuriosa."
DRAMP02787	SLQPGAPNVNNKDQPWQVSPHISRDDSGNTNTDINLQRHGENHDFDAGWSKVVRGPNKAKPTWHVGGTYRW	71	"Acaloleptin-A4 (chain of Acaloleptin A; Insects, animals)"	"P81592, Q76K70"	Belongs to the coleoptericin family	Not found	Acalolepta luxuriosa (Udo longhorn beetle)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Acaloleptins A4 show antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria.
Induction: By bacterial infection. Expression detected 2 hours post-injection, with expression increasing until 48 hours post-injection and remaining considerably high at least until 72 hours post-injection."	"Gram-negative bacteria: Escherichia coli, Aeromonas hydrophila, Erwinia persicinus, Serratia marcescens, Aeromonas hydrophila. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10077828##19527748	Arch Insect Biochem Physiol. 1999;40(2):88-98.##Dev Comp Immunol. 2009 Oct;33(10):1120-1127. 	"Imamura M, Wada S, Koizumi N, Kadotani T, Yaoi K, Sato R, Iwahana H.##Imamura M, Wada S, Ueda K, Saito A, Koizumi N, Iwahana H, Sato R."	"Acaloleptins A: inducible antibacterial peptides from larvae of the beetle, Acalolepta luxuriosa.##Multipeptide precursor structure of acaloleptin A isoforms, antibacterial peptides from the Udo longicorn beetle, Acalolepta luxuriosa."
DRAMP02803	GCASRCKAKCAGRRCKGWASASFRGRCYCKCFRC	34	"Mytilin-A (molluscas, animals)"	P81612	Not found	Not found	Mytilus edulis (Blue mussel)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity. It is active against the marine species Alteromonas carrageenovora, Pseudomonas alginovora and Cytophaga drobachiensis."	"Gram-positive bacteria: Aerococcus viridans, Bacillus megaterium, Micrococcus luteus, Enterococcus faecalis, Staphylococcus aureus;##Gram-negative bacteria: Escherichia coli, Alteromonas carrageenovora, Pseudomonas alginovora, Cytophaga drobachiensis."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8702979	J Biol Chem. 1996 Sep 6;271(36):21808-21813.	"Charlet M, Chernysh S, Philippe H, Hetru C, Hoffmann JA, Bulet P."	"Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis."
DRAMP02804	GFGCPNDYPCHRHCKSIPGRYGGYCGGXHRLRCTC	35	"Mytilus defensin-B (molluscas, animals)"	P81611	Belongs to the invertebrate defensin family (Type 2 subfamily)	Not found	Mytilus edulis (Blue mussel)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	Function: Has antibacterial activity.	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Micrococcus luteus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8702979	J Biol Chem. 1996 Sep 6;271(36):21808-21813.	"Charlet M, Chernysh S, Philippe H, Hetru C, Hoffmann JA, Bulet P."	"Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis."
DRAMP18235	LLEL	4	Gageopeptide D(Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antifungal, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	"Leu-Leu-Glu-Leu-3-beta-hydroxy-9,11-dimethyltetradecanoic acid"	None	"Non-cytotoxic antifungal agents. It was revealed that compounds 1 and 2 exhibited stronger antifungal activity than 3 and 4. Compounds 1 and 2 were structurally different from compounds 3 and 4 in terms of having less side chains in the fatty acid units, suggesting that the side chain length and the additional methyl group in the aliphatic chain are important for antifungal activity. These compounds also showed potent antimicrobial activity against Gram positive and Gram negative bacteria with MIC values of 0.04?0.08 uM."	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2485741	Yan Ke Xue Bao. 1989 Jun;5(1-2):32-5.	"Lin N, Gong XM, Xie QJ, Shao MR."	Study in cytotoxicity of gentamycin to corneal epithelium and endothelium in tissue culture.
DRAMP02816	RQKDKRPYSERKNQYTGPQFLYPPERIPP	29	Lumbrican	No entry found	Not found	Not found	Lumbricus rubellus (humus earthworm)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis ATCC 62037, Staphylococcus aureus ATCC 15752, Streptococcus mutans ATCC 25175;##Gram-negative bacteria: Escherichia coli ATCC 27325, Pseudomonas putida ATCC 17426, Serratia sp. ATCC 21074.##Fungi: Candida albicans ATCC 10231, Cryptococcus neoformans ATCC 34881, Saccharomyces cerevisiae ATCC 44774."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9784609	Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76.	"Cho JH, Park CB, Yoon YG, Kim SC."	"Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization."
DRAMP02818	ILQKAVLDCLKAAGSSLSKAAITAIYNKIT	30	Dicynthaurin	P0C007	Not found	Not found	Halocynthia aurantium (Sea peach)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix (CD)	"CD spectra of the cynthaurin monomer (Fig. 5A) and homodimer (Fig. 5B) in PBS showes properties characteristic of helical peptides. In structure-promoting environments, such as TFE:phosphate buffer or SDS micelles, the helical conformations are enhanced and accounted for the dominant structural component of both the monomeric and the homodimeric peptides."	None	"Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria. Its antimicrobial activity is optimal at NaCl concentrations below 100 mM, suggesting that the antimicrobial actions of this peptide may take place intracellularly rather than extracellularly. Has no activity against the fungus C.albicans. Has hemolytic activity.
PTM: Contians one disulfide bond and C-terminal amidation."	"[Ref.11479030]Gram-positive bacteria:?Micrococcus luteus, Staphylococcus aureus(50 units at 100ug/ml), Listeria monocytogenes(50 units at 40ug/ml);##Gram-negative bacteria:?Escherichia coli(50 units at 10ug/ml), Pseudomonas aeruginosa(25 units at 20ug/ml)."	"[Ref.11479030]10% hemolytic activity at 50 ¦Ìg/ml, 20% hemolytic activity at 100 ¦Ìg/ml against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11479030	Biochim Biophys Acta. 2001 Aug 15;1527(3):141-148.	"Lee IH, Lee YS, Kim CH, Kim CR, Hong T, Menzel L, Boo LM, Pohl J, Sherman MA, Waring A, Lehrer RI."	"Dicynthaurin: an antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium."
DRAMP02832	MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC	79	"Reactive oxygen species modulator 1 (ROS modulator 1; mammals, animals)"	Q3SZV8	Belongs to the MGR2 family	ROMO1	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	"Function: Has antibacterial activity against a variety of bacteria. Acts by inducing bacterial membrane breakage (By similarity).
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation."	"Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacteria: Pseudomonas aeruginosa, Mycobacterium tuberculosis."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases	Unknown	NIH - Mammalian Gene Collection (MGC) project
DRAMP02837	PLSCRRKGGICILIRCPGPMRQIGTCFGRPVKCCR	35	"Beta-defensin C7 (BBD(C7); mammals, animals)"	O18815	Belongs to the beta-defensin family	Not found	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram-"	Homology	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9488394	Infect Immun. 1998 Mar;66(3):1045-1056.	"Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL."	Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection.
DRAMP18233	LLLE	4	Gageopeptide B(Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antifungal, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Leu-Leu-Leu-OMeGlu-3-beta-hydroxy-12-methyltetradecanoic acid	None	"Non-cytotoxic antifungal agents. It was revealed that compounds 1 and 2 exhibited stronger antifungal activity than 3 and 4. Compounds 1 and 2 were structurally different from compounds 3 and 4 in terms of having less side chains in the fatty acid units, suggesting that the side chain length and the additional methyl group in the aliphatic chain are important for antifungal activity. These compounds also showed potent antimicrobial activity against Gram positive and Gram negative bacteria with MIC values of 0.04?0.08 uM."	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2485741	Yan Ke Xue Bao. 1989 Jun;5(1-2):32-5.	"Lin N, Gong XM, Xie QJ, Shao MR."	Study in cytotoxicity of gentamycin to corneal epithelium and endothelium in tissue culture.
DRAMP18234	LLEL	4	Gageopeptide C(Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antifungal, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	"Leu-Leu-Glu-Leu-3-beta-hydroxy-9,11-dimethyltridecanoic acid"	None	"Non-cytotoxic antifungal agents. It was revealed that compounds 1 and 2 exhibited stronger antifungal activity than 3 and 4. Compounds 1 and 2 were structurally different from compounds 3 and 4 in terms of having less side chains in the fatty acid units, suggesting that the side chain length and the additional methyl group in the aliphatic chain are important for antifungal activity. These compounds also showed potent antimicrobial activity against Gram positive and Gram negative bacteria with MIC values of 0.04?0.08 uM."	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2485741	Yan Ke Xue Bao. 1989 Jun;5(1-2):32-5.	"Lin N, Gong XM, Xie QJ, Shao MR."	Study in cytotoxicity of gentamycin to corneal epithelium and endothelium in tissue culture.
DRAMP02853	RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRP	59	"Cathelicidin-3 (Bactenecin-7, Bac7; PR-59; mammals, animals)"	"P19661, A5PJ95"	Belongs to the cathelicidin family	CATHL3	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms.
Tissue specificity: Large granules of neutrophils.
PTM: Contains two disulfide bonds."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2229048	J Biol Chem. 1990 Nov 5;265(31):18871-18874.	"Frank RW, Gennaro R, Schneider K, Przybylski M, Romeo D."	Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils.
DRAMP01356	FLGGLMKAFPALICAVTKKC	20	"Ranalexin-1Ca (Ranatuerin 1Ca; Frogs, amphibians, animals)"	P82876	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.	Not found	Rana clamitans (Green frog) (Lithobates clamitans)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. 
Tissue specificity: Expressed by the skin glands."	[Ref.10822101] Gram-positive bacterium: Staphylococcus aureus (MIC=17 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=4 ¦ÌM).##Yeast: Candida albicans (MIC=14 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10822101	Peptides. 2000 Apr;21(4):469-476.	"Halverson T, Basir YJ, Knoop FC, Conlon JM."	Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
DRAMP02864	QGVRNFVTCRINRGFCVPIRCPGHRRQIGTCLGPRIKCCR	40	"Bovine Beta-defensin 7 (bBD-7; BNBD-7; BNDB-7; mammals, animals)"	"P46165, Q32P80"	Belongs to the beta-defensin family	DEFB7	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A.
Tissue specificity: Neutrophilic granules.
PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)"	Gram-positive bacterium: Staphylococcus aureus 502A;##Gram-negative bacterium: Escherichia coli ML35	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8454635	J Biol Chem. 1993 Mar 25;268(9):6641-6648.	"Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS."	"Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."
DRAMP02871	RRHMLRCMGDLGICRPACRQSEEPYLYCRNYQPCCLPFYVRIDISGKEGKNDWSRENRWPKVS	63	"Beta-defensin 119 (Defensin, beta 119; mammals, animals)"	"Q32P86, A7LM95"	Belongs to the beta-defensin family	DEFB119	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Bridge	Not found	None	"Function Has antibacterial activity (Potential).
PTM: Contains three disulfide bonds (By similarity)."	"Gram-negative bacteria: Escherichia coli, Salmonella typhimurium;##Gram-positive bacteria: Staphylococcus aureus and Listeria monocytogenes."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases	"Cormican P, Meade K.G, Lloyd A.T, Cahalane S, Narciandi F, O'Farrelly C."	"Novel bovine AMPs exhibit constitutive tissue-specific gene expression and significant in vitro antimicrobial efficacy against Escherichia coli, Salmonella typhimurium, Stapylococcus aureus and Listeria monocytogenes."
DRAMP02902	ADDKNPLEEFRETNYEVFLEIAKNGLKATSNPKRVVIVGAGMAGLSAAY	49	"L-amino-acid oxidase (LAAO, LAO; BpirLAAO-I; reptilia, animals)"	P0C2D1	Belongs to the flavin monoamine oxidase family (FIG1 subfamily)	Not found	Bothrops pirajai (Piraja's lance head)	"Antimicrobial, Antibacterial, Anti-Gram-, Antiparasitic"	Protein level	Not found	Not found	None	"FunctionCatalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. This protein may also have activities in hemorrhage, hemolysis, and apoptosis.
Tissue specificity: Expressed by the venom gland.
Miscellaneous: Has parasiticidal activities against leishmania, as a result of enzyme-catalyzed hydrogen peroxide production."	"Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa. Leishmania sp.."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16809041	Bioorg Med Chem. 2006 Oct 15;14(20):7034-7043.	"Izidoro LF, Ribeiro MC, Souza GR, Sant'Ana CD, Hamaguchi A, Homsi-Brandeburgo MI, Goulart LR, Beleboni RO, Nomizo A, Sampaio SV, Soares AM, Rodrigues VM."	Biochemical and functional characterization of an L-amino acid oxidase isolated from Bothrops pirajai snake venom.
DRAMP02914	RICRIIFLRVCR	12	"Cathelicidin-1 (Bactenecin-1, Bac1; Cyclic dodecapeptide; ma"	P54230	Belongs to the cathelicidin family	CATHL1A	Ovis aries (Sheep)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Bridge	Not found	None	Function: Potent microbicidal activity; active against S. aureus and E. coli (By similarity).	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7498547##9461419	FEBS Lett. 1995 Dec 4;376(3):225-228.##Gene. 1998 Jan 5;206(1):85-91.	"Bagella L, Scocchi M, Zanetti M.##Huttner KM, Lambeth MR, Burkin HR, Burkin DJ, Broad TE."	cDNA sequences of three sheep myeloid cathelicidins.##Localization and genomic organization of sheep antimicrobial peptide genes.
DRAMP02929	GQALNKLMPKIVSAIIYMIGQPNAGVTFLGHQCLVESTRQPDGFYTAKMWCTSWTSDNPIVGEGRSRVELEALKGSIRNFVQTASDYKKFTIEEVEDWIAS	102	Antimicrobial protein 1	A1YV58	Not found	AP	Scylla serrata (Mud crab)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Tissue specificity: Strongly expressed in gills, hemocytes and reproductive tract, with weaker expression in muscle, heart and digestive tract. Not detected in eyes and hepatopancreas (at protein level)."	"Gram-positive bacteria: Escherichia coli (MIC<50 ?g/ml), Pseudomonas aeruginosa (MIC<25 ?g/ml);##Gram-negative bacteria: Staphylococcus aureus (MIC<100 ?g/ml), Streptococcus pyogenes (MIC<50 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19219229	Acta Biochim Pol. 2009;56(1):71-82.	"Yedery RD, Reddy KV."	"Purification and characterization of antibacterial proteins from granular hemocytes of Indian mud crab, Scylla serrata."
DRAMP02930	HSPGGA	6	"Antimicrobial protein 2 (crabs, Arthropods, animals)"	B3A0L8	Not found	Not found	Scylla serrata (Mud crab)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has antibacterial activity.	"Gram-positive bacterium: Bacillus flexus;##Gram-negative bacteria: Escherichia coli, Vibrio harveyi."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (SEP-2011) to UniProtKB	"Meiyalagan V, Arumugam M."	Antibacterial protein (Scylla serrata).
DRAMP02936	NPLIPAIYIGATVGPSVWAYLVALVGAAAVTAANIRRASSDNHSCAGNRGWCRSKCFRHEYVDTYYSAVCGRYFCCRSR	79	"Big defensin (crabs, Arthropods, animals)"	P80957	Belongs to the big defensin family	Not found	Tachypleus tridentatus (Japanese horseshoe crab)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	Not found	2RNG resolved by NMR.	"Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro.
Tissue specificity: Expressed in all tissues examined, including hemocytes, heart, hepatopancreas, stomach, intestine and skeletal muscle.
PTM: Contains three disulfide bonds."	"Gram-negative bacteria: Escherichia coli 09:K39 (IC50=5 ?g/ml), Salmonella typhimurium LT2 (IC50=20 ?g/ml), S. minnesota R595 (IC50=1.3 ?g/ml), Klebsiella pneumoniae (IC50>10 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (IC50<2.5 ?g/ml).##Yeast: Candida albicans (IC50>20 ?g/ml)(Ref.1).##Note: Washed with a phosphate buffered saline (PBS, pH 7.0)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	8586631##18785751	J Biochem. 1995 May;117(5):1131-1137.##Biochemistry. 2008 Oct 7;47(40):10611-9.	"Saito T, Kawabata S, Shigenaga T, Takayenoki Y, Cho J, Nakajima H, Hirata M, Iwanaga S.##Kouno T, Fujitani N, Mizuguchi M, Osaki T, Nishimura S, Kawabata S, Aizawa T, Demura M, Nitta K, Kawano K."	"A novel big defensin identified in horseshoe crab hemocytes: isolation, amino acid sequence, and antibacterial activity.##A novel beta-defensin structure: a potential strategy of big defensin for overcoming resistance by Gram-positive bacteria."
DRAMP02937	YLAFRCGRYSPCLDDGPNVNLYSCCSFYNCHKCLARLENCPKGLHYNAYLKVCDWPSKAGCTSVNKECHLWKT	73	"Tachycitin (crabs, Arthropods, animals)"	P91818	Not found	Not found	Tachypleus tridentatus (Japanese horseshoe crab)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Beta strand	Not found	1DQC resolved by NMR.	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Staphylococcus aureus (IC50=56 ?g/ml);##Gram-negative bacteria: Escherichia coli 363 (IC50=33 ?g/ml), Escherichia coli B (IC50=2 ?g/ml), Salmonella typhimurium LT2 (IC50=44 ?g/ml), S. minnesota R595 (IC50=41 ?g/ml), Klebsiella pneumoniae (IC50=32 ?g/ml).##Yeast: Candida albicans (IC50=52 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	9010778##10770921	J Biochem. 1996 Dec;120(6):1253-1260.##J Biol Chem. 2000 Jun 16;275(24):17929-17932.	"Kawabata S, Nagayama R, Hirata M, Shigenaga T, Agarwala KL, Saito T, Cho J, Nakajima H, Takagi T, Iwanaga S.##Suetake T, Tsuda S, Kawabata S, Miura K, Iwanaga S, Hikichi K, Nitta K, Kawano K."	"Tachycitin, a small granular component in horseshoe crab hemocytes, is an antimicrobial protein with chitin-binding activity.##Chitin-binding proteins in invertebrates and plants comprise a common chitin-binding structural motif."
DRAMP18230	LLLE	4	Gageotetrin B  (Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antifungal, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Leu-Leu-Leu-OMeGlu-3-hydroxy-11-methyltridecanoic acid (HTDA)	None	Noncytotoxic Antimicrobial Linear Lipopeptides	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	24502521	Org Lett. 2014 Feb 7;16(3):928-31. 	"Tareq FS, Lee MA, Lee HS, Lee YJ, Lee JS, Hasan CM, Islam MT, Shin HJ."	"Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis."
DRAMP18231	LLLE	4	Gageotetrin C (Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antifungal, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	"Leu-Leu-Leu-Glu-3-hydroxy-8,10-dimethyldodecanoic acid (HDDA)"	None	Noncytotoxic Antimicrobial Linear Lipopeptides	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	24502521	Org Lett. 2014 Feb 7;16(3):928-31. 	"Tareq FS, Lee MA, Lee HS, Lee YJ, Lee JS, Hasan CM, Islam MT, Shin HJ."	"Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis."
DRAMP18232	LLEL	4	Gageopeptide A(Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antifungal, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Leu-Leu-Glu-Leu-3-beta-hydroxy-11-methyltridecanoic acid	None	"Non-cytotoxic antifungal agents. It was revealed that compounds 1 and 2 exhibited stronger antifungal activity than 3 and 4. Compounds 1 and 2 were structurally different from compounds 3 and 4 in terms of having less side chains in the fatty acid units, suggesting that the side chain length and the additional methyl group in the aliphatic chain are important for antifungal activity. These compounds also showed potent antimicrobial activity against Gram positive and Gram negative bacteria with MIC values of 0.04?0.08 uM."	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2485741	Yan Ke Xue Bao. 1989 Jun;5(1-2):32-5.	"Lin N, Gong XM, Xie QJ, Shao MR."	Study in cytotoxicity of gentamycin to corneal epithelium and endothelium in tissue culture.
DRAMP02941	YSRCQLQGFNCVVRSYGLPTIPCCRGLTCRSYFPGSTYGRCQRF	44	"Tachystatin-A1 (crabs, Arthropods, animals)"	P0C1Z7	Not found	Not found	Tachypleus tridentatus (Japanese horseshoe crab)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Exhibits stronger antimicrobial activity against the Gram-positive bacterium S. aureus and fungi C. albicans and P. pastoris than Gram-negative bacterium E. coli. Binds to chitin (8.4 ?M are required to obtain 50% of binding). Does not cause hemolysis on sheep erythrocytes. Has no blocking activity on the P-type calcium channel.
Tissue specificity: Granular hemocytes, small secretory granules.
PTM: Contains three disulfide bonds (By similarity)."	"Gram-negative bacterium: Escherichia coli (IC50=25 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus (IC50=4.2 ?g/ml).##Fungi: Candida albicans (IC50=3.0 ?g/ml), Pichia pastoris (IC50=0.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	10473569	J Biol Chem. 1999 Sep 10;274(37):26172-26178.	"Osaki T, Omotezako M, Nagayama R, Hirata M, Iwanaga S, Kasahara J, Hattori J, Ito I, Sugiyama H, Kawabata S."	"Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins."
DRAMP02942	YSRCQLQGFNCVVRSYGLPTIPCCRGLTCRSYFPGSTYGRCQRY	44	"Tachystatin-A2 (crabs, Arthropods, animals)"	Q9U8X3	Not found	Not found	Tachypleus tridentatus (Japanese horseshoe crab)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Beta strand	Not found	1CIX resolved by NMR.	"Function: Exhibits stronger antimicrobial activity against the Gram-positive bacterium S. aureus and fungi C. albicans and P. pastoris than Gram-negative bacterium E. coli. Binds to chitin (8.4 ?M are required to obtain 50% of binding). Does not cause hemolysis on sheep erythrocytes. Has no blocking activity on the P-type calcium channel.
Tissue specificity: Granular hemocytes, small secretory granules.
PTM: Contains three disulfide bonds."	"Gram-positive bacterium: Staphylococcus aureus (IC50=4.2 ?g/ml);##Gram-negative bacterium: Escherichia coli (IC50=25 ?g/ml).##Fungi: Candida albicans (IC50=3.0 ?g/ml), Pichia pastoris (IC50=0.5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	10473569##11959852	J Biol Chem. 1999 Sep 10;274(37):26172-26178.##J Biol Chem. 2002 Jun 28;277(26):23651-23657.	"Osaki T, Omotezako M, Nagayama R, Hirata M, Iwanaga S, Kasahara J, Hattori J, Ito I, Sugiyama H, Kawabata S.##Fujitani N, Kawabata S, Osaki T, Kumaki Y, Demura M, Nitta K, Kawano K."	"Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins.##Structure of the antimicrobial peptide tachystatin A."
DRAMP02945	DYDWSLRGPPKCATYGQKCRTWSPPNCCWNLRCKAFRCRPR	41	"Tachystatin-C (crabs, Arthropods, animals)"	P0C200	Not found	Not found	Tachypleus tridentatus (Japanese horseshoe crab)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Causes hemolysis on sheep erythrocytes, probably by forming ion-permeable pores."	"Gram-negative bacterium: Escherichia coli (IC50=1.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus (IC50=0.8 ?g/ml).##Fungi: Candida albicans (IC50=0.9 ?g/ml), Pichia pastoris (IC50=0.3 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Chitin-binding	10473569	J Biol Chem. 1999 Sep 10;274(37):26172-26178.	"Osaki T, Omotezako M, Nagayama R, Hirata M, Iwanaga S, Kasahara J, Hattori J, Ito I, Sugiyama H, Kawabata S."	"Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins."
DRAMP18228	LLDVLLE	7	Gageostatin C (Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	"Leu-Leu-Asp-Val-Leu-Leu-Glu-(E)-7,9-dimethylundec-2-enoic acid"	None	"surfactin like heptapeptides, cytotoxic. It is noteworthy that these compounds 1"	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	24492520	Mar Drugs. 2014 Jan 31;12(2):871-85. 	"Tareq FS, Lee MA, Lee HS, Lee JS, Lee YJ, Shin HJ."	"Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis."
DRAMP18229	LE	2	Gageotetrin A (Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antifungal, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Leu-Glu-3-hydroxy-11-methyltridecanoic acid (HTDA)	None	Noncytotoxic Antimicrobial Linear Lipopeptides	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	24502521	Org Lett. 2014 Feb 7;16(3):928-31. 	"Tareq FS, Lee MA, Lee HS, Lee YJ, Lee JS, Hasan CM, Islam MT, Shin HJ."	"Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis."
DRAMP02955	LGAWLAGKVAGTVATYAWNRYV	22	"Hedistin (marine annelid, Metazoa)"	Q1PG44	Not found	Not found	Hediste diversicolor	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus (MRSA);##Gram-negative bacterium: Vibrio alginolyticus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17210178	Dev Comp Immunol. 2007;31(8):749-762. 	"Tasiemski A, Schikorski D, Le Marrec-Croq F, Pontoire-Van Camp C, Boidin-Wichlacz C, Sauti¨¨re PE."	"Hedistin: A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor."
DRAMP02968	AFPPPNVPGPRFPPPNFPGPRFPPPNFPGPRFPPPNFPGPRFPPPNFPGPPFPPPIFPGPWFPPPPPFRPPPFGPPRFP	79	"Prophenin-1 (C6, PF-1; Pro-rich; pigs, mammals, animals)"	P51524	Belongs to the cathelicidin family	Not found	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria.	Gram-positive bacterium: Listeria monocytogenes;##Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7698355##7576250	FEBS Lett. 1995 Mar 27;362(1):65-69.##Biol Chem Hoppe Seyler. 1995 Aug;376(8):507-510.	"Harwig SS, Kokryakov VN, Swiderek KM, Aleshina GM, Zhao C, Lehrer RI.##Strukelj B, Pungercar J, Kopitar G, Renko M, Lenarcic B, Berbi? S, Turk V."	"Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes.##Molecular cloning and identification of a novel porcine cathelin-like antibacterial peptide precursor."
DRAMP02969	AFPPPNVPGPRFPPPNVPGPRFPPPNFPGPRFPPPNFPGPRFPPPNFPGPPFPPPIFPGPWFPPPPPFRPPPFGPPRFP	79	"Prophenin-2 (C12, PF-2, PR-2; Pro-rich; pigs, mammals, animals)"	P51525	Belongs to the cathelicidin family	Not found	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria.	Gram-positive bacterium: Listeria monocytogenes;##Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8262247##7498526	FEBS Lett. 1993 Dec 27;336(2):284-288.##FEBS Lett. 1995 Dec 4;376(3):130-134.	"Pungercar J, Strukelj B, Kopitar G, Renko M, Lenarcic B, Gubensek F, Turk V.##Zhao C, Ganz T, Lehrer RI."	Molecular cloning of a putative homolog of proline/arginine-rich antibacterial peptides from porcine bone marrow.##Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39.
DRAMP02971	RGGRLCYCRRRFCICV	16	"Protegrin-2 (Protegrin 2; PG-2; pigs, mammals, animals)"	P32195	Belongs to the cathelicidin family	NPG2	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	2MUH resolved by NMR.	"Function: Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.
PTM: Contains two disulfide bonds 6-15; 8-13 and Valine amide at V16."	Gram-positive bacterium: Listeria moncyrogenes strain EGD (MIC>25 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35 (MIC>25 ?g/ml).##Yeast: Candida albicans strain 820 (MIC>25 ?g/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8335113##8250892	FEBS Lett. 1993 Jul 26;327(2):231-236.##Biochem Biophys Res Commun. 1993 Nov 15;196(3):1363-1368.	"Kokryakov VN, Harwig SS, Panyutich EA, Shevchenko AA, Aleshina GM, Shamova OV, Korneva HA, Lehrer RI.##Storici P, Zanetti M."	Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.##A novel cDNA sequence encoding a pig leukocyte antimicrobial peptide with a cathelin-like pro-sequence.
DRAMP02972	RGGGLCYCRRRFCVCVGR	18	"Protegrin-3 (Protegrin 3; PG-3; pigs, mammals, animals)"	P32196	Belongs to the cathelicidin family	NPG3	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	2MZ6 resolved by NMR.	"Function: Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.
PTM: Probablely contains two disulfide bonds 6-15; 8-13 and Arginine amide at R18."	Gram-positive bacterium: Listeria moncyrogenes strain EGD;##Gram-negative bacterium: Escherichia coli ML-35.##Yeast: Candida albicans strain 820.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8335113	FEBS Lett. 1993 Jul 26;327(2):231-236.	"Kokryakov VN, Harwig SS, Panyutich EA, Shevchenko AA, Aleshina GM, Shamova OV, Korneva HA, Lehrer RI."	Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.
DRAMP02976	NIGNSVSCLRNKGVCMPGKCAPKMKQIGTCGMPQVKCCKRK	41	"Beta-defensin 1 (BD-1; Defensin, beta 1; pigs, mammals, animals)"	O62697	Belongs to the beta-defensin family	DEFB1	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	"Function: Has bactericidal activity (By similarity).
PTM: Contains three disulfide bonds 8-37; 15-30; 20-38 (By similarity)."	"Gram-positive bacteria: Listeria monocytogenes, Streptococcus suis, Actinobacillus pleuropneumoniae;##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16552064##9537511##10446172	Infect Immun. 2006 Apr;74(4):2338-2352.##FEBS Lett. 1998 Mar 6;424(1-2):37-40.## Biol Chem. 1999 Aug 20;274(34):24031-24037.	"Elahi S, Buchanan RM, Attah-Poku S, Townsend HG, Babiuk LA, Gerdts V.##Zhang G, Wu H, Shi J, Ganz T, Ross CR, Blecha F.##Zhang G, Hiraiwa H, Yasue H, Wu H, Ross CR, Troyer D, Blecha F."	"The host defense peptide Beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets.##Molecular cloning and tissue expression of porcine beta-defensin-1.##Cloning and characterization of the gene for a new epithelial beta-defensin. Genomic structure, chromosomal localization, and evidence for its constitutive expression."
DRAMP02982	MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGPFSCLRIGMRGRELMGGIGKTMMQSGGTFGPFMAIGMGIRC	79	"Reactive oxygen species modulator 1 (ROS modulator 1; pigs, mammals, animals)"	A1XQR6	Belongs to the MGR2 family	romo1	Sus scrofa (Pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	"Function: Has antibacterial activity against a variety of bacteria. Acts by inducing bacterial membrane breakage (By similarity).
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).
Domain: Contains a transmembrane helix."	"Gram-positive bacteria: Staphylococcus aureus, Mycobacterium tuberculosis;##Gram-negative bacterium: Pseudomonas aeruginosa."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases	"Cai G, Chen Y, Wang C, Li J, Peng G, Zhang H."	Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library.
DRAMP02984	GLRKKFRKTRKRIQKLGRKIGKTGRKVWKAWREYGQIPYPCRI	43	"Neutrophil cationic antibacterial polypeptide of 11 kDa (CAP11; pigs, mammals, animals)"	Q91X12	Not found	CAP11	Cavia porcellus (Domestic guinea pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Shows antibacterial activity against the Gram-positive bacteium S. aureus and Gram-negative bacterium E. coli.	Gram-negative bacterium: Escherichia coli (ED50=30-35 nM);##Gram-positive bacterium: Staphylococcus aureus (ED50=90-120 nM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8644997	Arch Biochem Biophys. 1996 Apr 15;328(2):219-226.	"Yomogida S, Nagaoka I, Yamashita T."	Purification of the 11- and 5-kDa antibacterial polypeptides from guinea pig neutrophils.
DRAMP02985	RRCICTTRTCRFPYRRLGTCLFQNRVYTFCC	31	"Neutrophil cationic peptide 2 (CP-2; GNCP-2; pigs, mammals, animals)"	"P49112, Q9R0Z5"	Belongs to the alpha-defensin family	Not found	Cavia porcellus (Guinea pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Homology	Bridge	Not found	None	"Function: Has antibiotic, anti-fungi and antiviral activity.
PTM: Contains three disulfide bonds (By similarity)."	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8173076##10738945	DNA Seq. 1993;4(2):123-128.##Inflamm Res. 2000 Feb;49(2):73-79.	"Nagaoka I, Nonoguchi A, Yamashita T.##Nagaoka I, Hirota S, Yomogida S, Ohwada A, Hirata M."	Cloning and characterization of the guinea pig neutrophil cationic peptide-1 and -2 genes.##Synergistic actions of antibacterial neutrophil defensins and cathelicidins.
DRAMP02986	RRCICTTRTCRFPYRRLGTCIFQNRVYTFCC	31	"Neutrophil cationic peptide 1 (GPNP; Antiviral defensin; pigs, mammals, animals)"	"Q64365, P11478"	Belongs to the alpha-defensin family	Not found	Cavia porcellus (Guinea pig)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Protein level	Bridge	Not found	None	"Function: Has antibiotic, anti-fungi and antiviral activity.
Tissue specificity: Bone marrow."	"Gram-positive bacteria: Staphylococcus aureus, Streptococcus;##Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2473036##3623703	Infect Immun. 1989 Aug;57(8):2405-2409.##Infect Immun. 1987 Sep;55(9):2281-2286.	"Yamashita T, Saito K.##Selsted ME, Harwig SS."	"Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides.##Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin."
DRAMP02989	VNWKKVLGKIIKVAK	15	"Lasioglossin LL-I (Insects, animals)"	No entry found	Not found	Not found	Lasioglossum laticeps (Eusocial Bee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"Function: Active against B. subtilis, S. aureus, P. aeruginosa, and E. coli. Low hemolytic toxicity."	"[Ref.19591185]Gram-positive bacteria:?B. subtilis(MIC=0.8 ¦ÌM), S. aureus(MIC=14.3 ¦ÌM);##Gram-negative bacteria:?P. aeruginosa(MIC=15.8 ¦ÌM), E. coli(MIC=1.7 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2099.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP02990	VNWKKILGKIIKVAK	15	"Lasioglossin LL-II (Insects, animals)"	No entry found	Not found	Not found	Lasioglossum laticeps (Eusocial Bee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"Function: Active against B. subtilis, S. aureus, P. aeruginosa, and E. coli. Low hemolytic toxicity."	"[Ref.19591185]Gram-positive bacteria:?B. subtilis(MIC=0.7 ¦ÌM), S. aureus(MIC=9.0 ¦ÌM);##Gram-negative bacteria:?P. aeruginosa(MIC=14.4 ¦ÌM), E. coli(MIC=1.4 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2099.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP02991	VNWKKILGKIIKVVK	15	"Lasioglossin LL-III (Insects, animals)"	No entry found	Not found	Not found	Lasioglossum laticeps (Eusocial Bee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Not found	Not found	Not found	None	"Function: Active against B. subtilis, S. aureus, P. aeruginosa, and E. coli. Low hemolytic toxicity."	"[Ref.19591185]Gram-positive bacteria:?B. subtilis(MIC=0.7 ¦ÌM), S. aureus(MIC=3.9 ¦ÌM);##Gram-negative bacteria:?P. aeruginosa(MIC=18.7 ¦ÌM), E. coli(MIC=1.4 ¦ÌM)."	[Ref.19591185]LC50>220 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2099.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP03004	FVPYNPPRPGQSKPFPSFPGHGPFNPKIQWPYPLPNPGH	39	"Abaecin (Insects, animals)"	P81463	Not found	Not found	Bombus pascuorum (Brown bumblebee)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide against Gram-positive and Gram-negative bacteria.
Induction: By bacterial infection."	Gram-negative bacteria: Micrococcus luteus;##Gram-negative bacteria: Escherichia coli D22.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9219367	Insect Biochem Mol Biol. 1997 May;27(5):413-22.	"Rees JA, Moniatte M, Bulet P."	"Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea)."
DRAMP03005	GNRPVYIPPPRPPHPRL	17	"Apidaecin (Insects, animals)"	P81464	Belongs to the apidaecin family	Not found	Bombus pascuorum (Brown bumblebee)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide against Gram-positive and Gram-negative bacteria.
Induction: By bacterial infection."	Gram-negative bacteria: Micrococcus luteus;##Gram-negative bacteria: Escherichia coli D22.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9219367	Insect Biochem Mol Biol. 1997 May;27(5):413-422.	"Rees JA, Moniatte M, Bulet P."	"Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea)."
DRAMP04531	AAGMGFFGAR	10	Urechistachykinin II (UII)	P40752	Not found	Not found	Urechis unicinctus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Antifungal. Has no hemolytic activity.	"[Ref.18570895] Gram-negative bacteria: Escherichia coli O-157 (MIC=12.7¦ÌM), Pseudomonas aeruginosa (MIC=12.7¦ÌM), Vibrio vulnificu (MIC=25.4¦ÌM) ;##Gram-positive bacteria: Streptococcus mutans (MIC=12.7¦ÌM), Staphylococcus aureus (MIC=25.4¦ÌM),Enterococcus faecium(MIC=25.4¦ÌM) ;##Fungi: Candida albicans(MIC=25.4¦ÌM), Trichosporon beigelii (MIC=12.7¦ÌM), Malassezia furfur (MIC=50.9¦ÌM)."	[Ref.18570895] Has no hemolytic activities against human erythrocyte cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18570895	FEBS Lett. 2008 Jul 9;582(16):2463-2466.	"Sung WS, Park SH, Lee DG."	"        Antimicrobial effect and membrane-active mechanism of Urechistachykinins, neuropeptides derived from Urechis unicinctus.

"
DRAMP04530	LRQSQFVGSR	10	Urechistachykinins I (UI)	P40751	Not found	Not found	Urechis unicinctus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Antifungal. Has no hemolytic activity.	"[Ref.18570895] Gram-negative bacteria: Escherichia coli O-157 (MIC=10.6¦ÌM), Pseudomonas aeruginosa (MIC=21.3¦ÌM), Vibrio vulnificus (MIC=42.5¦ÌM) ;##Gram-positive bacteria: Streptococcus mutans(MIC=21.3¦ÌM), Staphylococcus aureus (MIC=42.5¦ÌM),Enterococcus faecium (MIC=21.3¦ÌM) ;##Fungi: Candida albicans (MIC=42.5¦ÌM), Trichosporon beigelii (MIC=21.3¦ÌM), Malassezia furfur (MIC=42.5¦ÌM)."	[Ref.18570895] Has no hemolytic activities against human erythrocyte cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18570895	FEBS Lett. 2008 Jul 9;582(16):2463-2466.	"Sung WS, Park SH, Lee DG."	"        Antimicrobial effect and membrane-active mechanism of Urechistachykinins, neuropeptides derived from Urechis unicinctus.

"
DRAMP01224	GFISTVKNLATNVAGTVIDTIKCKVTGGC	29	"Palustrin-2AR (Palustrin-2ARa; Ranatuerin-2SEa; Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana areolata (North American crawfish frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacterium Escherichia coli. Has hemolytic activity.	[Ref.12429503] Gram-negative bacterium: Escherichia coli (MIC=110 ¦ÌM)	[Ref.12429503] HC50>300 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys23 and Cys29)	Disulfide bond between Cys23 and Cys29.	L	No cytotoxicity information found	Not found	12429503	Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63.	"Ali MF, Lips KR, Knoop FC, Fritzsch B, Miller C, Conlon JM."	"Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata."
DRAMP03023	INWKALLDAAKKVL	14	"Mastoparan (Protonectarina-MP; Insects, animals)"	P0C1Q5	Not found	Not found	Protonectarina sylveirae (Brazilian wasp)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Shows potent antimicrobial action against both Gram-positive and Gram-negative bacteria By similarity. This peptide shows potent histamine releasing activities on rat peritoneal mast cells. Also Has hemolytic and cytolytic activity.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (Leucine amide: L14)."	[Swiss_Prot Entry P0C1Q5]Potent antimicrobial peptide against both Gram-positive and Gram-negative bacteria (By similarity)	[Ref.20108158]ED50 =3.4 ¡Á 10?5 M against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7513243##19857508##20108158	Nat Toxins. 1993;1(5):271-276.##Toxicon. 2010 Apr 1;55(4):711-718.##Amino Acids. 2011 Jan;40(1):77-90.	"Dohtsu K, Okumura K, Hagiwara K, Palma MS, Nakajima T.##Baek JH, Lee SH.##de Souza BM, Dos Santos Cabrera MP, Neto JR, Palma MS."	Isolation and sequence analysis of peptides from the venom of Protonectarina sylveirae (Hymenoptera-Vespidae).##Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).##Investigating the effect of different positioning of lysine residues along the peptide chain of mastoparans for their secondary structures and biological activities.
DRAMP03025	INLKAIAALAKKLL	14	Mastoparan M	No entry found	Not found	Not found	Vespa magnifica	"Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=6.0 ¡À 3.5 mg/L, MBC=6.0 ¡À 3.5 mg/L), Enterococcus faecalis isolates(MIC=5.3 ¡À 2.3 mg/L, MBC=6.7 ¡À 2.3 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=4.0 ¡À 3.5 mg/L, MBC=4.7 ¡À 3.0 mg/L), Acinetobacter baumannii isolates(MIC=2.7 ¡À 1.2 mg/L, MBC=3.3 ¡À 1.2 mg/L)"	"[Ref.27591703] 0% hemolysis at 64 ¦Ìg/ml against human red blood cells; 0% hemolysis at 32 ¦Ìg/ml , 6% hemolysis at 64 ¦Ìg/ml against sheep red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15935330##27591703	Biochem Pharmacol. 2005 Jul 15;70(2):209-219. ##Chem Biol Drug Des.?2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864.	"Yibin G, Jiang Z, Hong Z, Gengfa L, Liangxi W, Guo W, Yongling L.##Memariani H,?Shahbazzadeh D,?Ranjbar R,?Behdani M,?Memariani M,?Pooshang Bagheri K"	"A synthesized cationic tetradecapeptide from hornet venom kills bacteria and neutralizes lipopolysaccharide in vivo and in vitro.##Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B."
DRAMP18227	LLDVLLE	7	Gageostatin B (Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	"Leu-Leu-Asp-Val-Leu-Leu-Glu-3-beta-hydroxy-9, 11-dimethyltridecanoic acid"	None	"surfactin like heptapeptides, cytotoxic. It is noteworthy that these compounds 1"	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	24492520	Mar Drugs. 2014 Jan 31;12(2):871-85. 	"Tareq FS, Lee MA, Lee HS, Lee JS, Lee YJ, Shin HJ."	"Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis."
DRAMP03049	GRILSFIKGLAEHL	14	"Eumenine mastoparan-OD (EMP-OD; Venom peptide 1, OdVP1; Insects, animals)"	"P86146, C7DT07"	Belongs to the MCD family (Mastoparan subfamily)	VP1	Orancistrocerus drewseni (Solitary wasp)	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has hemolytic activity against ovine erythrocytes at micromolar concentrations. Also exhibits strong antimicrobial activity.
Tissue specificity: Expressed by the venom gland.
PTM: C-terminal amidation (Leucine amide: L14)."	"[Ref.19857508]Fungi: Candida albicans, Botrytis cinerea (++);##Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: S. aureus (+)"	[Ref.18695936]42% hemolytic activity at 50 ¦ÌM against sheep blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen	19857508##18695936	Toxicon. 2010 Apr 1;55(4):711-718.##Amino Acids. 2009 Jul;37(2):389-394.	"Baek JH, Lee SH.##Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T."	"Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).##Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni."
DRAMP03062	VTGELKRDKRVTCNIGEWVCVAHCNSKSKKSGYCSRGVCYCTN	43	"Defensin-A (DefA; GmDefA; Insects, animals)"	Q8WTD4	Belongs to the invertebrate defensin family (Type 1 subfamily)	Not found	Glossina morsitans morsitans (Savannah tsetse fly)	"Antimicrobial, Antibacterial, Anti-Gram-, Antiprotozoal"	Protein level	Not found	Not found	None	"Function: Antibacterial peptide mostly active against Gram-positive and Gram-negative bacteria.
Tissue specificity: Hemolymph and fat body.
Induction: By bacterial infection. 
PTM: Contains three disulfide bonds (By similarity)."	Protozoan: Procyclic trypanosomes (IC50=10 ?M).##Gram-negative bacteria: Sodalis (IC50=2 ?M)£¬Escherichia coli DH5¦Á (IC50=0.2 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11592981##11886771	Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12648-12653.##Insect Biochem Mol Biol. 2002 Apr;32(4):369-375.	"Hao Z, Kasumba I, Lehane MJ, Gibson WC, Kwon J, Aksoy S.##Boulanger N, Brun R, Ehret-Sabatier L, Kunz C, Bulet P."	Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis.##Immunopeptides in the defense reactions of Glossina morsitans to bacterial and Trypanosoma brucei brucei infections.
DRAMP18226	LLDVLLE	7	Gageostatin A (Bacteriocin)	No entry found	Belongs to the lipopeptides family	Not found	Bacillus subtilis	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	Leu-Leu-Asp-Val-Leu-Leu-Glu-3-beta-hydroxy-11-methyltridecanoic acid	None	"Fuction: Surfactin like heptapeptides, cytotoxic. It is noteworthy that these compounds 1"	"Gram-positive, Gram-negative"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	24492520	Mar Drugs. 2014 Jan 31;12(2):871-85. 	"Tareq FS, Lee MA, Lee HS, Lee JS, Lee YJ, Shin HJ."	"Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis."
DRAMP03071	DEKPKLILPTPAPPNLPQLVGGGGGNRKDGFGVSVDAHQKVWTSDNGGHSIGVSPGYSQHLPGPYGNSRPDYRIGAGYSYNF	82	"Diptericin-A (Insects, animals)"	P10836	Belongs to the attacin/sarcotoxin-2 family	Not found	Protophormia terraenovae (Northern blowfly)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has activity against E.coli.
Miscellaneous: There seems to be a family of diptericin in protophormia. Diptericin A is the predominant member."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	3276515	Eur J Biochem. 1988 Jan 15;171(1-2):17-22.	"Dimarcq JL, Keppi E, Dunbar B, Lambert J, Reichhart JM, Hoffmann D, Rankine SM, Fothergill JE, Hoffmann JA."	"Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A."
DRAMP03072	DEKPKLILPTPAPPNLPQLVGGGGGNRKDGFGVSVDAHQKVWTSDNGRHSIGVTPGYSQHLGGPYGNSRPDYRIGAGYSYNF	82	"Diptericin-D (Insects, animals)"	P18684	Belongs to the attacin/sarcotoxin-2 family	Not found	Protophormia terraenovae (Northern blowfly)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has activity against E.coli.
Induction: By bacterial infection.
Miscellaneous: There seems to be a family of diptericin in protophormia. Diptericin A is the predominant member."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2544427	Eur J Biochem. 1989 Jun 15;182(2):423-437.	"Reichhart JM, Essrich M, Dimarcq JL, Hoffmann D, Hoffmann JA, Lagueux M."	"Insect immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera). Transcriptional profiles during immunization."
DRAMP03073	ATCDLLSGIGVQHSACALHCVFRGNRGGYCTGKGICVCRN	40	"Sapecin-C (Sapecin C; defensins; Insects, animals)"	P31530	Belongs to the invertebrate defensin family (Type 1 subfamily)	Not found	Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Sapecins, which are potent bactericidal proteins, are produced in response to body injury. Thus, sapecin is probably a defense protein synthesized by Sarcophaga to prevent bacterial infection through the damaged body wall. This gene was also found to be activated in the embryonic and early pupal stages, suggesting that sapecin also plays a role in the ontogenetic processes of Sarcophaga."	"Gram-negative bacteria: Escherichia coli, Proteus mirabilis, Klebsiella Pneumoniae;##Gram-positive bacteria: Staphylococcus spps., Streptococcus spps, Bacillus megaterium, Bacillus circulans, Corynebacterium glutamicum."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8471044	Biochem J. 1993 Apr 1;291 (Pt 1):275-279.	"Yamada K, Natori S."	"Purification, sequence and antibacterial activity of two novel sapecin homologues from Sarcophaga embryonic cells: similarity of sapecin B to charybdotoxin."
DRAMP03083	LTCEIDRSLCLLHCRLKGYLRAYCSQQKVCRCVQ	34	"Sapecin-B (defensins; Insects, animals)"	P31529	Belongs to the invertebrate defensin family (Type 1 subfamily)	Not found	Sarcophaga peregrina (Flesh fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Sapecins, which are potent bactericidal proteins, are produced in response to body injury. Thus, sapecin is probably a defense protein synthesized by Sarcophaga to prevent bacterial infection through the damaged body wall. This gene was also found to be activated in the embryonic and early pupal stages, suggesting that sapecin also plays a role in the ontogenetic processes of Sarcophaga."	"Gram-negative bacteria: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae;##Gram-positive bacteria: Staphylococcus spps., Streptococcus spps, Bacillus megaterium, Bacillus circulans, Corynebacterium glutamicum."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7635204##8471044	FEBS Lett. 1995 Jul 24;368(3):485-487.##Biochem J. 1993 Apr 1;291 (Pt 1):275-279.	"Lee SR, Kurata S, Natori S.##Yamada K, Natori S."	"Molecular cloning of cDNA for sapecin B, an antibacterial protein of Sarcophaga, and its detection in larval brain.##Purification, sequence and antibacterial activity of two novel sapecin homologues from Sarcophaga embryonic cells: similarity of sapecin B to charybdotoxin."
DRAMP03084	SIGSAFKKALPVAKKIGKAALPIAKAALP	29	"Ceratotoxin-B (Insects, animals)"	P36191	Not found	CTXB	Ceratitis capitata (Mediterranean Fruit fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	"Function: Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria. They have as well hemolytic activity.
Temperature dependence: Thermostable. Still active at 100 degrees Celsius."	[Swiss_Prot Entry P36191]Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria	[Swiss_Prot Entry P36191]has hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8353519	Insect Biochem Mol Biol. 1993 Jul;23(5):591-598.	"Marchini D, Giordano PC, Amons R, Bernini LF, Dallai R."	"Purification and primary structure of ceratotoxin A and B, two antibacterial peptides from the female reproductive accessory glands of the medfly Ceratitis capitata (Insecta:Diptera)."
DRAMP03085	SIGSALKKALPVAKKIGKIALPIAKAALP	29	"Ceratotoxin-A (Insects, animals)"	"P36190, O17512"	Not found	CTXA1	Ceratitis capitata (Mediterranean Fruit fly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	"Function: Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.
Temperature dependence: Thermostable. Still active at 100 degrees Celsius."	[Swiss_Prot Entry P36190]Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria	[Swiss_Prot Entry P36190]has hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8353519##7890755	Insect Biochem Mol Biol. 1993 Jul;23(5):591-598.##J Biol Chem. 1995 Mar 17;270(11):6199-6204.	"Marchini D, Giordano PC, Amons R, Bernini LF, Dallai R.##Marchini D, Manetti AG, Rosetto M, Bernini LF, Telford JL, Baldari CT, Dallai R. "	"Purification and primary structure of ceratotoxin A and B, two antibacterial peptides from the female reproductive accessory glands of the medfly Ceratitis capitata (Insecta:Diptera).##cDNA sequence and expression of the ceratotoxin gene encoding an antibacterial sex-specific peptide from the medfly Ceratitis capitata (diptera)."
DRAMP03086	SIGTAVKKAVPIAKKVGKVAIPIAKAVLSVVGQLVG	36	"Ceratotoxin-D (Insects, animals)"	O17513	Not found	CTXD	Ceratitis capitata (Mediterranean Fruit fly) (Tephritis capitata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.
Biophysicochemical properties: Temperature dependence (Thermostable. Still active at 100 degrees Celsius)."	[Swiss_Prot Entry O17513]Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria	[Swiss_Prot Entry O17513]has hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9569644	Insect Biochem Mol Biol. 1997 Dec;27(12):1039-1046.	"Rosetto M, De Filippis T, Manetti AG, Marchini D, Baldari CT, Dallai R."	The genes encoding the antibacterial sex-specific peptides ceratotoxins are clustered in the genome of the medfly Ceratitis capitata.
DRAMP03101	GWLRKIGKKIERVGQHTRDATIQVLGIAQQAANVAATAR	39	"Sarcotoxin-1C (Sarcotoxin IC; Insects, animals)"	P08377	Belongs to the cecropin family	Not found	Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Sarcotoxins, which are potent bactericidal proteins, are produced in response to injury. They are cytotoxic to both Gram-positive and Gram-negative bacteria.
PTM: Problely Arginine amide at R39."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	3888997	J Biol Chem. 1985 Jun 25;260(12):7174-7177.	"Okada M, Natori S."	"Primary structure of sarcotoxin I, an antibacterial protein induced in the hemolymph of Sarcophaga peregrina (flesh fly) larvae."
DRAMP03102	GWLKKIGKKIERVGQHTRDATIQVIGVAQQAANVAATAR	39	"Sarcotoxin-1B (Sarcotoxin IB; Insects, animals)"	P08376	Belongs to the cecropin family	Not found	Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Sarcotoxins, which are potent bactericidal proteins, are produced in response to injury. They are cytotoxic to both Gram-positive and Gram-negative bacteria.
PTM: Problely Arginine amide at R39."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	3888997##2689214	J Biol Chem. 1985 Jun 25;260(12):7174-7177.##FEBS Lett. 1989 Dec 4;258(2):199-202.	"Okada M, Natori S.##Kanai A, Natori S."	"Primary structure of sarcotoxin I, an antibacterial protein induced in the hemolymph of Sarcophaga peregrina (flesh fly) larvae.##Cloning of gene cluster for sarcotoxin I, antibacterial proteins of Sarcophaga peregrina."
DRAMP18223	CWSCMGHSCWSCMGHSCWSCAGHSCWSCMGHSCWSCMGHSCWSCAGHCCGSCWHGGM	57	Sonorensin(Bacteriocin)	X2CRH8	Belongs to the class I bacteriocin	Not found	Bacillus sonorensis MT93	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	"The Clustal W alignment of the N terminus of sonorensin revealed homology with the leader sequences of protoxins from various Bacillus strains. This indicated that sonorensin, produced initially as a protoxin, was posttransitionally modified to active bacteriocin. The purified sonorensin was also found to be heat stable, stable at low temperature, biologically active over a wide pH range, and not affected in the presence of organic solvents, surfactants, and reducing agents. However, sonoresin was protease-sensitive."	"Gram-positive, Gram-negative (broad spectrum)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	24610839	Appl Environ Microbiol. 2014 May;80(10):2981-90. 	"Chopra L, Singh G, Choudhary V, Sahoo DK."	"Sonorensin: an antimicrobial peptide, belonging to the heterocycloanthracin subfamily of bacteriocins, from a new marine isolate, Bacillus sonorensis MT93."
DRAMP03134	ATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCPI	40	"Defensin-D (AaeDefD; Insects, animals)"	No entry found	Not found	Not found	Aedes aegypti (Yellowfever mosquito)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli D31;##Gram-positive bacterium: Micrococcus luteus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10469248	Insect Mol Biol. 1999 Aug;8(3):311-318.	"Gao Y, Hernandez VP, Fallon AM."	Immunity proteins from mosquito cell lines include three defensin A isoforms from Aedes aegypti and a defensin D from Aedes albopictus.
DRAMP03154	GILDTIKSIASKVWNSKTVQDLKRKGINWVANKLGVSPQAA	41	Hadrurin (Non-disulfide-bridged peptide 3.1)	P82656	Belongs to the antimicrobial peptide scorpion family	Not found	Hadrurus aztecus 	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has antimicrobial activity. Also shows cytolytic activity when tested in human erythrocytes.	"Gram-negative bacteria: Salmonella typhimurium, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10931184	Eur J Biochem. 2000 Aug;267(16):5023-5031.	"Torres-Larios A, Gurrola GB, Zamudio FZ, Possani LD."	"Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus."
DRAMP03157	ALLHHGLNCAKGVLA	15	Halocidin subunit B	P83706	Not found	Not found	Halocynthia aurantium (Sea peach)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antimicrobial activity, possibly by attacking the bacterial cell membrane."	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Pseudomonas aeruginosa.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12067731	FEBS Lett. 2002 Jun 19;521(1-3):81-86.	"Jang WS, Kim KN, Lee YS, Nam MH, Lee IH."	"Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium."
DRAMP03158	WLNALLHHGLNCAKGVLA	18	"Halocidin subunit A (invertebrates, animals; Preclinical)"	P83705	Not found	Not found	Halocynthia aurantium (Sea peach)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against S.aureus and P.aeruginosa, possibly by attacking the bacterial cell membrane. Mouse model: A single intravenous injection of the modified chain A by itself into mice resulted in an significant therapeutic effect (Jang et al. 2007;51: 4148-4156)."	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Pseudomonas aeruginosa.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12067731	FEBS Lett. 2002 Jun 19;521(1-3):81-86.	"Jang WS, Kim KN, Lee YS, Nam MH, Lee IH."	"Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium."
DRAMP03163	ATCDLFSFRSKWVTPNHAACAAHCLLRGNRGGRCKGTICHCRK	43	"R. prolixus defensin A (RprDefA; insect defensin; Insects, animals)"	No entry found	Not found	Not found	Rhodnius prolixus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal"	Not found	Combine helix and strand structure	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Micrococcus luteus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12650692	Insect Biochem Mol Biol. 2003 Apr;33(4):439-447.	"Lopez L, Morales G, Ursic R, Wolff M, Lowenberger C."	"Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas disease."
DRAMP03164	ATCDLLSFRSKWVTPNHAGCAAHCLLRGNRGGHCKGTICHCRK	43	"R. prolixus defensin B (RprDefB; insect defensin; Insects, animals)"	No entry found	Not found	Not found	Rhodnius prolixus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal"	Not found	Combine helix and strand structure	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Micrococcus luteus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12650692	Insect Biochem Mol Biol. 2003 Apr;33(4):439-447.	"Lopez L, Morales G, Ursic R, Wolff M, Lowenberger C."	"Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas disease."
DRAMP03165	ATCDLFSFRSKWVTPNHAGCAAHCIFLGNRGGRCVGTVCHCRK	43	"R. prolixus defensin C (RprDefC; insect defensin; Insects, animals)"	No entry found	Not found	Not found	Rhodnius prolixus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal"	Not found	Combine helix and strand structure	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Micrococcus luteus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12650692	Insect Biochem Mol Biol. 2003 Apr;33(4):439-447.	"Lopez L, Morales G, Ursic R, Wolff M, Lowenberger C."	"Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas disease."
DRAMP03174	RWCVYAYVRIRGVLVRYRRCW	21	"Arenicin-2 (Ar-2; marine polychaeta, animals)"	"Q5SC59, P84106"	Not found	Not found	Arenicola marina (Lugworm) (Lumbricus marinus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand (2 strands; 16 residues)	"NMR investigation shows that in water solution arenicin-2 displays a prolonged beta-hairpin, formed by two antiparallel beta-strands and stabilized by one disulfide and nine hydrogen bonds. A significant right-handed twist in the beta-sheet is deprived the peptide surface of amphipathicity. CD spectroscopic analysis indicates that arenicin-2 binds to the SDS and DPC micelles, and conformation of the peptide is significantly changed upon"	"2JNI, 2L8X resolved by NMR."	"Function: Has antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteriua as well as yeast C. albicans. Bacterial killing occurs within minutes and is accompanied by membrane permeabilization, membrane detachment and release of cytoplasm. Interaction of arenicin with reconstituted membranes that mimic the lipopolysaccharide-containing outer membrane or the phospholipid-containing plasma membrane of Gram-negative bacteria exhibited no pronounced lipid specificity.
PTM: Contains one disulfide bond 3-20.
Domian: Contains 1 BRICHOS domain."	Gram-positive bacterium: Listeria monocytogenes EGD;##Gram-negative bacterium: Escherichia coli ML-35p.##Yeast: Candida albicans 820.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys20.	L	No cytotoxicity information found	Anionic lipid vesicles	15527787##17935487##17585874	FEBS Lett. 2004 Nov 5;577(1-2):209-214.##Biochem J. 2008 Feb 15;410(1):113-122.##Biochem Biophys Res Commun. 2007 Aug 17;360(1):156-162.	"Ovchinnikova TV, Aleshina GM, Balandin SV, Krasnosdembskaya AD, Markelov ML, Frolova EI, Leonova YF, Tagaev AA, Krasnodembsky EG, Kokryakov VN.##Andr? J, Jakovkin I, Gr?tzinger J, Hecht O, Krasnosdembskaya AD, Goldmann T, Gutsmann T, Leippe M.##Ovchinnikova TV, Shenkarev ZO, Nadezhdin KD, Balandin SV, Zhmak MN, Kudelina IA, Finkina EI, Kokryakov VN, Arseniev AS."	"Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina.##Structure and mode of action of the antimicrobial peptide arenicin.##Recombinant expression, synthesis, purification, and solution structure of arenicin."
DRAMP03175	FNKLKQGSSKRTCAKCFRKIMPSVHELDERRRGANRWAAGFRKCVSSICRY	51	Perinerin	"P84117, P83551"	Not found	Not found	Nereis aibuhitensis (Clamworm) (Perinereis aibuhitensis)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Antibacterial activity against both Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli K-12, Proteus vulgaris;##Gram-positive bacteria: Bacillus megaterium, Aerococcus viridans, Staphylococcus aureus, Micrococcus luteus."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15113828	J Biochem. 2004 Mar;135(3):297-304.	"Pan W, Liu X, Ge F, Han J, Zheng T."	"Perinerin, a novel antimicrobial peptide purified from the clamworm Perinereis aibuhitensis grube and its partial characterization."
DRAMP03180	AVDFSSCARMDVPGLSKVAQGLCISSCKFQNCGTGHCEKRGGRPTCVCDRCGRGGGEWPSVPMPKGRSSRGRRHS	75	"ASABF-alpha (ASABF; nematodes, animals)"	P90683	Not found	asabf-alpha	Ascaris suum (Pig roundworm) (Ascaris lumbricoides)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Combine helix and strand structure	Not found	2D56 resolved by NMR.	Slight hemolytic activity against human erythrocytes. 	"[Ref.10991847]Gram-negative bacteria: Escherichia coli JM109 (IC50=50 ?g/ml), Proteus vulgaris ATCC 13315 (IC50=10 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC6538P (IC50=0.6 ?g/ml), Bacillus subtilis ATCC6633 (IC50=1.2 ?g/ml), Micrococcus luteus ATCC398 (IC50=0.8 ?g/ml)."	[Ref.10991847]4.5% hemolytic activity at 1000 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8940016##10991847	J Biol Chem. 1996 Nov 29;271(48):30493-30498.##Antimicrob Agents Chemother. 2000 Oct;44(10):2701-2715.	"Kato Y, Komatsu S.##Zhang H, Yoshida S, Aizawa T, Murakami R, Suzuki M, Koganezawa N, Matsuura A, Miyazawa M, Kawano K, Nitta K, Kato Y."	"ASABF, a novel cysteine-rich antibacterial peptide isolated from the nematode Ascaris suum. Purification, primary structure, and molecular cloning of cDNA.##In vitro antimicrobial properties of recombinant ASABF, an antimicrobial peptide isolated from the nematode Ascaris suum."
DRAMP03183	DAECEICKFVIQQVEAFIESNHSQAEIQKELNKL	34	Naegleriapore A 	Q95X03	Not found	NP-A	Naegleria fowleri (Brain eating amoeba)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal, Cytotoxic"	Predicted	Alpha helix 	It is characterized by a structure of amphipathic ¦Á-helices and an invariant framework of cysteine residues involved in disulfide bonds.	None	"Function: Posesses antibacterial, cytotoxicity and pore-forming activity. In concentrations up to 10 ?m, naegleriapore A is inactive against the Gram-negative bacterium E. coli D31. The specific pore-forming activities of naegleriapore A and B are 3.1¡À1.7 units pmol?1 and 3.7¡À1.3 units pmol?1, respectively."	Gram-negative bacterium: Escherichia coli K-12 D31;##Gram-positive bacterium: Bacillus subtilis strain 60015.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11948186	J Biol Chem. 2002 Jun 21;277(25):22353-22360.	"Herbst R, Ott C, Jacobs T, Marti T, Marciano-Cabral F, Leippe M."	Pore-forming polypeptides of the pathogenic protozoon Naegleria fowleri.
DRAMP03184	SVIGCEICEWLVATAEGFVNKTKPQIEQELLQICAKLGPYEQICDQLVLMELPDIIDQIIAKEPPAIVCSQVKICNG	77	Naegleriapore B 	Q95X02	Not found	NP-B	Naegleria fowleri (Brain eating amoeba) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal, Cytotoxic"	Predicted	Alpha helix 	It is characterized by a structure of amphipathic ¦Á-helices and an invariant framework of cysteine residues involved in disulfide bonds.	None	"Function: Posesses antibacterial, cytotoxicity and pore-forming activity. Naegleriapore B does not exert any antibacterial activity in concentration up to 10 ?m against the bacteria tested. The specific pore-forming activities of naegleriapore A and B are 3.1¡À1.7 units pmol?1 and 3.7¡À1.3 units pmol?1, respectively."	Gram-negative bacterium: Escherichia coli K-12 D31;##Gram-positive bacterium: Bacillus subtilis strain 60015.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11948186	J Biol Chem. 2002 Jun 21;277(25):22353-22360.	"Herbst R, Ott C, Jacobs T, Marti T, Marciano-Cabral F, Leippe M."	Pore-forming polypeptides of the pathogenic protozoon Naegleria fowleri.
DRAMP03188	RLGGILRKAGEKIGGGLKKIGQKIKDFFGKLAPRTES	37	"Antibacterial protein LL-37 (primates, mammals, animals)"	Q1KLX0	Belongs to the cathelicidin family	CAMP	Saguinus oedipus (Cotton-top tamarin)	"Antimicrobial, Antibacterial, Anti-Gram-"	Homology	Bridge	Not found	None	Function: Has antibacterial activity (By similarity).	"Gram-negative bacteria: Escherichia coli ML-35, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus 710A, Enterococcus faecalis A16.##Yeast: Candida albicans clinical isolate."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	16720578	J Biol Chem. 2006 Jul 21;281(29):19861-19871.	"Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A."	Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.
DRAMP03199	RRICRCRIGRCLGLEVYFGVCFLHGRLARRCCR	33	"PhD1 (PhD-1; Defensin-1; primates, mammals, animals)"	P84757	Not found	Not found	Papio hamadryas (Hamadryas baboon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli;##Gram-positive bacteria: Listeria monocytogenes, Staphylococcus aureus.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16978151	Biochemistry (Mosc). 2006 Aug;71(8):879-883.	"Tsvetkova EV, Aleshina GM, Shamova OV, Leonova LE, Lehrer RI, Kokryakov VN."	alpha-Defensins from blood leukocytes of the monkey Papio hamadryas.
DRAMP03200	RICRCRIGRCLGLEVYFGVCFLHGRLARRCCR	32	"PhD2 (PhD-2; Defensin-2; primates, mammals, animals)"	P84757	Belongs to the alpha-defensin family	Not found	Papio hamadryas (Hamadryas baboon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli;##Gram-positive bacteria: Listeria monocytogenes, Staphylococcus aureus.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16978151	Biochemistry (Mosc). 2006 Aug;71(8):879-83.	"Tsvetkova EV, Aleshina GM, Shamova OV, Leonova LE, Lehrer RI, Kokryakov VN."	alpha-Defensins from blood leukocytes of the monkey Papio hamadryas.
DRAMP03201	RTCRCRLGRCSRRESYSGSCNINGRIYSLCCR	32	"PhD3 (PhD-3; Defensin-3; primates, mammals, animals)"	P84758	Belongs to the alpha-defensin family	Not found	Papio hamadryas (Hamadryas baboon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacterium: Escherichia coli;##Gram-positive bacteria: Listeria monocytogenes, Staphylococcus aureus.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16978151	Biochemistry (Mosc). 2006 Aug;71(8):879-883.	"Tsvetkova EV, Aleshina GM, Shamova OV, Leonova LE, Lehrer RI, Kokryakov VN."	alpha-Defensins from blood leukocytes of the monkey Papio hamadryas.
DRAMP03208	RCVCTRGFCRCVCRRGVC	18	"BTD-1 (theta-defensin; primates, mammals, animals)"	"B6ULW4, P86031, B6ULW5, P86032"	Not found	Not found	Papio anubis (Olive baboon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: BTD-1 has antimicrobial activity against the Gram-negative bacterium E. coli ML35 and the Gram-positive bacterium S. aureus 502a, and the fungus C. albicans 16820. "	Gram-positive bacterium: Staphylococcus aureus 502a;##Gram-negative bacterium: Escherichia coli ML35.##Fungi: Candida albicans 16820.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	18852242	Infect Immun. 2008 Dec;76(12):5883-5891.	"Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME."	"Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes."
DRAMP03209	RCVCRRGVCRCVCRRGVC	18	"BTD-2 (theta-defensin; primates, mammals, animals)"	"B6ULW5, P86032"	Not found	Not found	Papio anubis (Olive baboon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: BTD-2 has antimicrobial activity against the Gram-negative bacterium E. coli ML35 and the Gram-positive bacterium S. aureus 502a, and the fungus C. albicans 16820. Among the five BTDs detected, the most potent peptide is BTD-2. BTD-2 is more effective against E. coli than BTD-1."	Gram-positive bacterium: Staphylococcus aureus 502a;##Gram-negative bacterium: Escherichia coli ML35.##Fungi: Candida albicans 16820.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	18852242	Infect Immun. 2008 Dec;76(12):5883-5891.	"Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME."	"Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes."
DRAMP03211	RCVCTRGFCRCICLLGIC	18	"BTD-4 (theta-defensin; primates, mammals, animals)"	"B6ULW4, B6ULW6"	Not found	Not found	Papio anubis (Olive baboon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: BTD-4 has antimicrobial activity against the Gram-negative bacterium E. coli ML35 and the Gram-positive bacterium S. aureus 502a, and the fungus C. albicans 16820. Among the five BTD detected, BTD-4 is least positively charged (net charge +2). This may be responsible for its weaker antimicrobial activity observed in vitro. It disrupts E. coli membranes."	Gram-positive bacterium: Staphylococcus aureus 502a;##Gram-negative bacterium: Escherichia coli ML35.##Fungi: Candida albicans 16820.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	18852242	Infect Immun. 2008 Dec;76(12):5883-5891.	"Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME."	"Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes."
DRAMP03212	RCVCTRGFCRCFCRRGVC	18	"BTD-7 (theta-defensin; primates, mammals, animals)"	"B6ULW4, B6ULW7"	Not found	Not found	Papio anubis (Olive baboon)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: BTD-7 has antimicrobial activity against the Gram-negative bacterium E. coli ML35 and the Gram-positive bacterium S. aureus 502a, and the fungus C. albicans 16820. "	Gram-positive bacterium: Staphylococcus aureus 502a;##Gram-negative bacterium: Escherichia coli ML35.##Fungi: Candida albicans 16820.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	18852242	Infect Immun. 2008 Dec;76(12):5883-5891.	"Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME."	"Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes."
DRAMP03224	GFGSLFKFLAKKVAKTVAKQAAKQGAKYIANKQTE	35	"M-ctenitoxin-Cs1c (M-CNTX-Cs1c; Cupiennin-1c; spiders, Arthropods, animals)"	P83621	Belongs to the cupiennin family	Not found	Cupiennius salei (Wandering spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has antimicrobial activity. Probably acts by disturbing membrane Function: with its amphipathic structure.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853;##Gram-positive bacteria: Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11792701	J Biol Chem. 2002 Mar 29;277(13):11208-11216.	"Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W."	"Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae)."
DRAMP03238	GFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYVLKYYGKKALQKASEKL	69	"M-zodatoxin-Lt8c (M-ZDTX-Lt8c; Cytoinsectotoxin-1c, CIT-1c; spiders, Arthropods, animals)"	"P85255, B3W6I1"	Belongs to the cytoinsectotoxin family	cit 1-3	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal"	Protein level	Not found	Not found	None	"Function: Insecticidal, cytolytic and antimicrobial peptide. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis(By similarity).
Tissue specificity: Expressed by the venom gland."	"Gram-positive bacteria: Micrococcus luteus VKM Ac-2230, Staphylococcus aureus 209P, Arthrobacter globiformis VKM Ac-1112, Bacillus subtilis VKM B-501;##Gram-negative bacteria: Escherichia coli C600, E. coli DH5?¡À, E. coli MH1, Pseudomonas aeruginosa PAO1, Pseudomonas fluorescens VKM B-894, Serratia marcescens VKM B-1248."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18215128	Biochem J. 2008 May 1;411(3):687-696.	"Vassilevski A.A, Kozlov S.A, Samsonova O.V, Egorova N.S, Karpunin D.V, Pluzhnikov K.A, Feofanov A.V, Grishin E.V."	"Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom."
DRAMP03241	GFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKHYGKKALQKASEKL	69	"M-zodatoxin-Lt8f (M-ZDTX-Lt8f; Cytoinsectotoxin-1f, CIT-1f; spiders, Arthropods, animals)"	"P85258, B3W6I4"	Belongs to the cytoinsectotoxin family	cit 1-7	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram-, Insecticidal"	Protein level	Not found	Not found	None	"Function: Insecticidal, cytolytic and antimicrobial peptide. Has insecticidal activity against the flesh fly S. carnaria. Has antibacterial activity against the Gram-negative bacteria E.coli. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Tissue specificity: Expressed by the venom gland."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18215128	Biochem J. 2008 May 1;411(3):687-696.	"Vassilevski A.A, Kozlov S.A, Samsonova O.V, Egorova N.S, Karpunin D.V, Pluzhnikov K.A, Feofanov A.V, Grishin E.V."	"Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom."
DRAMP03242	GFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYVLKHYGKKALQKASEKL	69	"M-zodatoxin-Lt8g (M-ZDTX-Lt8g; Cytoinsectotoxin-1g, CIT-1g; spiders, Arthropods, animals)"	"P85259, B3W6I5"	Belongs to the cytoinsectotoxin family	cit 1-8	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram-, Insecticidal"	Protein level	Not found	Not found	None	"Function: Has insecticidal activity against the flesh fly S. carnaria. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Tissue specificity: Expressed by the venom gland."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18215128	Biochem J. 2008 May 1;411(3):687-696.	"Vassilevski A.A, Kozlov S.A, Samsonova O.V, Egorova N.S, Karpunin D.V, Pluzhnikov K.A, Feofanov A.V, Grishin E.V."	"Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom."
DRAMP03243	GFFGNAWKKIKGKAEKFFRKKAAKIIAKKEGITKEEAEAKVDTMSKKQIKVYLLKHYGKKALQKASEKL	69	"M-zodatoxin-Lt8h (M-ZDTX-Lt8h; Cytoinsectotoxin-1h, CIT-1h; spiders, Arthropods, animals)"	"P85247, B3W6I6"	Belongs to the cytoinsectotoxin family	cit 1-11	Lachesana tarabaevi (Spider)	"Antimicrobial, Antibacterial, Anti-Gram-, Insecticidal"	Protein level	Not found	Not found	None	"Function: Has insecticidal activity against the flesh fly S. carnaria. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Tissue specificity: Expressed by the venom gland."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18215128	Biochem J. 2008 May 1;411(3):687-696.	"Vassilevski A.A, Kozlov S.A, Samsonova O.V, Egorova N.S, Karpunin D.V, Pluzhnikov K.A, Feofanov A.V, Grishin E.V."	"Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom."
DRAMP18213	VKLFPVKLFP	10	Gramicidin S(Bacteriocin)	No entry found	Not found	Not found	Bacillus brevis	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Beta sheet	"The second and seventh residues of this cyclic peptide are Ornithines, an analog of lysine (one CH2 shorter). They are represented here with lysines. In addition, residue F is a D-amino acid."	None	"Function: This is the first cyclic peptide antibiotic used clinically. For gram-negative bacteria, however,  activity  was strongly dependent on whether the assay was carried out in solution or in agar. It was found that GS was active against gram-negative microorganisms in the solution-based  assay, but inactive against these using an agar-based  assay. GS was also found to have antifungal activity when measured using a  liquid-broth assay. "	"Gram-positive, Gram-negative (broad-spectrum)"	It exhibits hemolytic activity at 25 ¦ÌM and 45 ¦ÌM against human red cells and sheep red cells.	Cyclic	No specific N-terminal	No specific C-terminal	The 'O' in sequence is Ornithine	Mixed(D-Phe)	No cytotoxicity information found	Cell membrane	8836773##24388950	Int J Pept Protein Res. 1996 Jun;47(6):460-6.##Biochim Biophys Acta. 2014 May;1838(5):1420-9. 	"Kondejewski LH, Farmer SW, Wishart DS, Hancock RE, Hodges RS.##Abraham T, Prenner EJ, Lewis RN, Mant CT, Keller S, Hodges RS, McElhaney RN."	"Gramicidin S is active against both gram-positive and gram-negative bacteria.##Structure-activity relationships of the antimicrobial peptide gramicidin S and its analogs: aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes."
DRAMP03282	GKREKCLRRNGFCAFLKCPTLSVISGTCSRFQVCC	35	"Turkey Heterophil Peptide 1 (Antimicrobial peptide THP1; Birds, animals)"	P80391	Belongs to the beta-defensin family	Not found	Meleagris gallopavo (Common turkey)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge 	Not found	None	PTM: Contains two disulfide bonds 	Gram-negative bacterium: Escherichia coli ATCC 25922;##Gram-positive bacterium: Staphylococcus aureus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7964174	J Leukoc Biol. 1994 Nov;56(5):661-665.	"Evans EW, Beach GG, Wunderlich J, Harmon BG."	Isolation of antimicrobial peptides from avian heterophils.
DRAMP03304	QIVDCWETWSRCTKWSQGGTGTLWKSCNDRCKELGRKRGQCEEKPSRCPLSKKAWTCICY	60	"Hydramacin-1 (Hm-1; annelida, animals)"	B3RFR8	Belongs to the macin family	Not found	Hydra vulgaris (Hydra) (Hydra attenuata)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	The molecule possesses two short ¦Á-helices (residues 10-14 and 27-33) at the N terminus which are separated by a long flexible loop. The C-terminal region contains two ¦Â-strands (residues 38-42 and 56-60) in an antiparallel arrangement separated by a long flexible loop. 	2K35 resolved by NMR.	"Function: Hydramacin-1 is potently active against Gram-positive and Gram-negative bacteria including multi-resistant human pathogenic strains. Is not active against the Gram-positive Coccus species, Gram-negative non-fermentation species and against the fungus C.albicans. It leads to aggregation of bacteria as an initial step of its bactericidal mechanism. Aggregated cells are connected via electron-dense contacts and adopt a thorn apple-like morphology. Hydramycin contains a belt of positively charged residues that separate two hydrophobic areas. This structure may explain the observed aggregation of bacteria, since each of these areas can immerse into the outer leaflets of the membranes of two individual bacteria. Is able to permeabilize membranes of viable bacteria at low and neutral pH values, but no pore-forming activity is not detected.
Tissue specificity: Expressed in the endodermal epithelium.
Induction: By bacterial lipopolysaccharides (LPS).
PTM: Contains four disulfide bonds."	"Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MBC=7.1 ?M), Burkholderia cepacia ATCC 25416 (MBC>14.3 ¦ÌM),Burkholderia cepacia ATCC 17759 (MBC>14.3 ¦ÌM), B. cepacia LMG 16654 (MBC>14.3 ¦ÌM), Citrobacter freundii NCTC 9750 (MBC=7.1 ¦ÌM), C. freundii C7 (MBC=0.9 ¦ÌM), Enterobacter cloacae Va11263/03 (MBC>14.3 ¦ÌM), E. cloacae Va12270/03 (MBC=0.9 ¦ÌM), Escherichia coli ATCC 25922 (MBC=0.9 ¦ÌM), Klebsiella pneumoniae ATCC 13883 (MBC=0.9 ¦ÌM), Klebsiella oxytoca ATCC 13182 (MBC=0.9 ¦ÌM), Proteus mirabilis ATCC 21100 (MBC=14.3 ¦ÌM), P. vulgaris ATCC 13315 (MBC>14.3 ¦ÌM), Providencia rettgeri NCTC 7475 (MBC>14.3 ¦ÌM), Pseudomonas aeruginosa NCTC 11446 (MBC>14.3 ¦ÌM), Salmonella typhimurium 10003442 (MBC=0.9 ¦ÌM), S. typhimurium 10003630 (MBC=0.9 ¦ÌM), Serratia marcescens Mero060/148 (MBC>14.3 ?M), S. marcescens Mero103/013 (MBC>14.3 ¦ÌM), S. marcescens NCTC 10211 (MBC>14.3 ¦ÌM), Yersinia enterocolitica NCTC 11176 (MBC=0.9 ?M).##Multi-resistant Gram-negative bacteria: Escherichia coli Co 86 ESBL (MBC=3.6 ¦ÌM), Klebsiella oxytoca ESBL 33 (MBC=7.1 ?M), K. oxytoca ESBL 37 (MBC=3.6 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MBC=3.6 ¦ÌM).##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MBC>14.3 ¦ÌM), Staphylococcus haemolyticus ATCC 29970 (MBC=1.8 ¦ÌM), Streptococcus pyogenes ATCC 12344 (MBC>14.3 ¦ÌM).##Multi-resistant Gram-positive bacteria: Staphylococcus aureus ATCC 33593 (MRSA) (MBC>14.3 ¦ÌM), Enterococcus faecalis ATCC 51299 (MBC>14.3 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	cell membrane	19013190##19019828	Dev Comp Immunol. 2009 Apr;33(4):559-569.##J Biol Chem. 2009 Jan 16;284(3):1896-1905.	"Bosch TC, Augustin R, Anton-Erxleben F, Fraune S, Hemmrich G, Zill H, Rosenstiel P, Jacobs G, Schreiber S, Leippe M, Stanisak M, Gr?tzinger J, Jung S, Podschun R, Bartels J, Harder J, Schr?der JM.##Jung S, Dingley AJ, Augustin R, Anton-Erxleben F, Stanisak M, Gelhaus C, Gutsmann T, Hammer MU, Podschun R, Bonvin AM, Leippe M, Bosch TC, Gr?tzinger J."	"Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence.##Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra."
DRAMP03317	AKRGGFWRKVGRKLGKGIRKIGKTIKSQLGKFRPRLQYRYQF	42	Cathelicidin-related antimicrobial peptide (AMPs)	Q0R5P1	Not found	CRAMP	Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: Escherichia coli, Moraxella catarrhalis 1857;##Gram-positive bacterium: Streptococcus pneumoniae serotype 14."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17113647	Mol Immunol. 2007 Mar;44(9):2446-2458.	"McGillivary G, Ray WC, Bevins CL, Munson RS Jr, Bakaletz LO."	A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media.
DRAMP03329	LRDLVCYCRSRGCKGRERMNGTCRKGHLLYTLCCR	35	"Alpha-defensin cryptdin-1 (Crp1; Rodents, mammals, animals)"	"P11477, Q61448"	Belongs to the alpha-defensin family	Defa1	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Probably contributes to the antimicrobial barrier Function: of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S. typhimurium.
Tissue specificity: Paneth cells of the small bowel. 
Developmental stage: Accumulates to high levels in mouse intestinal crypt epithelium during postnatal development.
PTM: Contains three disulfide bonds (By similarity). "	"Gram-positive bacterium: Listeria monocytogenes EGD;##Gram-negative bacteria: Escherichia coli ML-35p, mouse-avirulent Salmonella typhimurium 7953."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys6 and Cys34,Cys8 and Cys23,Cys13 and Cys33."	L	No cytotoxicity information found	Not found	1500431	J Cell Biol. 1992 Aug;118(4):929-936.	"Selsted ME, Miller SI, Henschen AH, Ouellette AJ."	Enteric defensins: antibiotic peptide components of intestinal host defense.
DRAMP03330	LRDLVCYCRTRGCKRRERMNGTCRKGHLMYTLCCR	35	"Alpha-defensin cryptdin-2 (Defensin-related cryptdin-2; Rodents, mammals, animals)"	"P28309, P82293, Q60616, Q62537"	Belongs to the alpha-defensin family	Defa2	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge 	Not found	None	"Function: Has broad-spectrum antibacterial activity. Probably contributes to the antimicrobial barrier Function: of the small bowel mucosa.
Tissue specificity: Paneth cells of the small bowel.
PTM: Contains three disulfide bonds 6-34; 8-23; 13-33 (By similarity)."	"Gram-positive bacterium: Listeria monocytogenes EGD;##Gram-negative bacteria: Escherichia coli ML-35p, mouse-avirulent Salmonella typhimurium 7953."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys6 and Cys34,Cys8 and Cys23,Cys13 and Cys33."	L	No cytotoxicity information found	Not found	1500431##1500163	J Cell Biol. 1992 Aug;118(4):929-936.##Infect Immun. 1992 Sep;60(9):3556-3565.	"Selsted ME, Miller SI, Henschen AH, Ouellette AJ.##Eisenhauer PB, Harwig SS, Lehrer RI."	Enteric defensins: antibiotic peptide components of intestinal host defense.##Cryptdins: antimicrobial defensins of the murine small intestine.
DRAMP03331	LRDLVCYCRKRGCKRRERMNGTCRKGHLMYTLCCR	35	"Alpha-defensin cryptdin-3 (Defensin-related cryptdin-3; Rodents, mammals, animals)"	"P28310, Q499K7"	Belongs to the alpha-defensin family	Defa3	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Probably contributes to the antimicrobial barrier Function: of the small bowel mucosa.
Tissue specificity: Paneth cells of the small bowel.
PTM: Contains three disulfide bonds (By similarity). "	"Gram-positive bacterium: Listeria monocytogenes EGD;##Gram-negative bacteria: Escherichia coli ML-35p, mouse-avirulent Salmonella typhimurium 7953."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys6 and Cys34,Cys8 and Cys23,Cys13 and Cys33."	L	No cytotoxicity information found	Not found	1500431	J Cell Biol. 1992 Aug;118(4):929-936.	"Selsted ME, Miller SI, Henschen AH, Ouellette AJ."	Enteric defensins: antibiotic peptide components of intestinal host defense.
DRAMP03332	LRGLLCYCRKGHCKRGERVRGTCGIRFLYCCPRR	34	"Alpha-defensin cryptdin-4 (Defensin-related cryptdin4; Rodents, mammals, animals)"	"P28311, A3KPC1, Q9QZL4"	Belongs to the alpha-defensin family	Defa4	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Beta strand (3 strands; 18 residues)	Not found	"2GW9, 1TV0, 2GWP, 2LEW, 2LEY resolved by NMR."	"Function: Probably contributes to the antimicrobial barrier Function: of the small bowel mucosa.
Tissue specificity: Paneth cells of the small bowel.
PTM: Contains three disulfide bonds. "	"Gram-positive bacterium: Listeria monocytogenes EGD;##Gram-negative bacteria: Escherichia coli ML-35p, mouse-avirulent Salmonella typhimurium 7953."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys6 and Cys31,Cys8 and Cys23,Cys13 and Cys30."	L	No cytotoxicity information found	Phospholipid	15595831##7927786##16857681	Biochemistry. 2004 Dec 21;43(50):15759-15766.##Infect Immun. 1994 Nov;62(11):5040-5047.##J Biol Chem. 2006 Sep 22;281(38):28068-78.	"Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ.##Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME.##Rosengren KJ, Daly NL, Fornander LM, J?nsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ."	"Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin.##Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.##Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4."
DRAMP03333	SKKLICYCRIRGCKRRERVFGTCRNLFLTFVFCCS	35	"Alpha-defensin cryptdin-5 (Defensin-related cryptdin5; Rodents, mammals, animals)"	"P28312, Q64382"	Belongs to the alpha-defensin family	Defa5	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Probably contributes to the antimicrobial barrier Function: of the small bowel mucosa.
PTM: Contains three disulfide bonds."	"Gram-positive bacterium: Listeria monocytogenes EGD;##Gram-negative bacteria: Escherichia coli ML-35p, mouse-avirulent Salmonella typhimurium 7953."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys6 and Cys34,Cys8 and Cys23,Cys13 and Cys33."	L	No cytotoxicity information found	Not found	1500431	J Cell Biol. 1992 Aug;118(4):929-936.	"Selsted ME, Miller SI, Henschen AH, Ouellette AJ."	Enteric defensins: antibiotic peptide components of intestinal host defense.
DRAMP03334	DLVCYCRARGCKGRERMNGTCRKGHLLYMLCCR	33	"Alpha-defensin cryptdin-6/12 (Defensin-related cryptdin-6/12; Rodents, mammals, animals)"	"P50704, P50710, P82294"	Belongs to the alpha-defensin family	Defa6 AND Defa12	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	"Function: Has broad-spectrum antibacterial activity. Probably contributes to the antimicrobial barrier Function: of the small bowel mucosa.
Tissue specificity: Paneth cells of the small bowel.
PTM: Contains three disulfide bondss 4-32; 6-21; 11-31. Probably contributes to the antimicrobial barrier Function: of the small bowel mucosa."	"Gram-positive bacterium: Listeria monocytogenes EGD;##Gram-negative bacteria: Escherichia coli ML-35p, mouse-avirulent Salmonella typhimurium 7953."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys4 and Cys32,Cys6 and Cys21,Cys11 and Cys31."	L	No cytotoxicity information found	Not found	7927786##1500163	Infect. Immun. 1994;62:5040-5047.##Infect. Immun. 1992;60:3556-3565.	"Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME.##Eisenhauer P.B, Harwig S.S.S.L, Lehrer R.I."	Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.##Cryptdins: antimicrobial defensins of the murine small intestine.
DRAMP03357	LQDAALGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK	38	"Cryptdin related sequence peptide (CRS4C-1a; Rodents, mammals, animals)"	"Q70LV2, Q70LV8, Q70LV7, Q70LV6, Q70LV4"	Not found	Defa-rs2	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Antimicrobial peptide that defense response to Gram-negative bacterium and Gram-positive bacterium.
MOA: CRS peptides were able to bind LPS and to reduce its immunostimulatory activity, leading to a substantial reduction in cellular activation."	"Gram-positive bacteria: Enterococcus faecalis (LC=1.9 ?M), Lactobacillus fermentum DSM 20052 (LC=1.1 ?M), Strepococcus pyogenes clinical isolate (LC=0.4 ?M), Listeria monocytogenes type 1 clinical isolate (LC=1.4 ?M);##Gram-negative bacteria: Escherichia coli strain D21 (LC=2.4 ?M), Salmonella typhimurium ATCC 14028 (LC=1.7 ?M).##NOTE: Dimerized peptide was two- to fourfold more potent than monomeric peptide. LC, Lethal concentrations."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	15235601	Nat Immunol. 2004 Aug;5(8):836-843.	"Hornef MW, P¨¹tsep K, Karlsson J, Refai E, Andersson M."	Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.
DRAMP03358	LQDAAVGWGRRCPQCPRCPSCPSCPRCPRCPRCKCNPK	38	"Cryptdin related sequence peptide (CRS4C-1d; Rodents, mammals, animals)"	"Q70LV9, Q70LV5, Q70LV3"	Not found	Defa-rs4	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	"Function: Antimicrobial peptide that defense response to Gram-negative bacterium and Gram-positive bacterium.
MOA: CRS peptides were able to bind LPS and to reduce its immunostimulatory activity, leading to a substantial reduction in cellular activation."	"Gram-negative bacterium: Salmonella typhimurium ATCC 14028;##Gram-positive bacteria: Enterococcus faecalis, Listeria monocytogenes type 1 clinical isolate, Streptococcus pyogenes clinical isolate."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	15235601	Nat Immunol. 2004 Aug;5(8):836-843.	"Hornef MW, P¨¹tsep K, Karlsson J, Refai E, Andersson M."	Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.
DRAMP03359	LQDAALGWGRRCPRCPPCPRCSWCPRCPTCPRCNCNPK	38	"Cryptdin related sequence peptide (CRS4C-2; Rodents, mammals, animals)"	"Q70LV0, Q70LU3"	Not found	Defa-rs7	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	"Function: Antimicrobial peptide that defense response to Gram-negative bacterium and Gram-positive bacterium.
MOA: CRS peptides were able to bind LPS and to reduce its immunostimulatory activity, leading to a substantial reduction in cellular activation."	"Gram-negative bacterium: Salmonella typhimurium ATCC 14028;##Gram-positive bacteria: Enterococcus faecalis, Listeria monocytogenes type 1 clinical isolate, Streptococcus pyogenes clinical isolate."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	15235601	Nat Immunol. 2004 Aug;5(8):836-843.	"Hornef MW, P¨¹tsep K, Karlsson J, Refai E, Andersson M."	Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.
DRAMP03360	LQDAALGWGRRCPRCPPCPRCSWCPRCPTCPGCNCNPK	38	"Cryptdin related sequence peptide (CRS4C-2b; Rodents, mammals, animals)"	Q70LV1	Not found	Defa-rs7	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Predicted	Not found	Not found	None	"Function: Antimicrobial peptide that defense response to Gram-negative bacterium and Gram-positive bacterium.
MOA: CRS peptides were able to bind LPS and to reduce its immunostimulatory activity, leading to a substantial reduction in cellular activation."	"Gram-negative bacterium: Salmonella typhimurium ATCC 14028;##Gram-positive bacteria: Enterococcus faecalis, Listeria monocytogenes type 1 clinical isolate, Streptococcus pyogenes clinical isolate."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	15235601	Nat Immunol. 2004 Aug;5(8):836-843.	"Hornef MW, P¨¹tsep K, Karlsson J, Refai E, Andersson M."	Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.
DRAMP03362	LQDAALGWSRRCPRCPPCPNCRRCPRCPTCPSCNCNPK	38	"CRS4C-3c (Cryptdin related sequence peptide; Rodents, mammals, animals)"	No entry found	Not found	Not found	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Antimicrobial peptide that defense response to Gram-negative bacterium and Gram-positive bacterium.
MOA: CRS peptides were able to bind LPS and to reduce its immunostimulatory activity, leading to a substantial reduction in cellular activation."	"Gram-negative bacterium: Salmonella typhimurium ATCC 14028;##Gram-positive bacteria: Enterococcus faecalis, Listeria monocytogenes type 1 clinical isolate, Streptococcus pyogenes clinical isolate."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	15235601	Nat Immunol. 2004 Aug;5(8):836-843.	"Hornef M.W, Putsep K, Karlsson J, Refai E, Andersson M."	Increased diversity of intestinal antimicrobial peptides by covalent dimer formation.
DRAMP03366	DQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	37	"Beta-defensin 1 (BD-1; mBD-1; Defensin, beta 1; Rodents, mammals, animals)"	P56386	Belongs to the beta-defensin family	Not found	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Bridge	Not found	None	PTM: Contains three disulfide bonds 5-34; 12-27; 17-35.	"Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa;##Gram-positive bacterium: Staphylococcus aureus."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9287114	FEBS Lett. 1997 Aug 11;413(1):45-49.	"Huttner KM, Kozak CA, Bevins CL."	The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1.
DRAMP03368	KKINNPVSCLRKGGRCWNRCIGNTRQIGSCGVPFLKCCKRK	41	"Beta-defensin 3 (BD-3, mBD-3; Defensin, beta 3; Rodents, mammals, animals)"	"Q9WTL0, Q29R78"	Belongs to the beta-defensin family	Defb3	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Bridge	Not found	None	"PTM: Contains three disulfide bonds 9-37; 17-30; 20-38. Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue. By bacterial infection."	"Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys9 and Cys37,Cys17 and Cys30,Cys20 and Cys38."	L	No cytotoxicity information found	Not found	10377137	Infect Immun. 1999 Jul;67(7):3542-3547.	"Bals R, Wang X, Meegalla R.L, Wattler S, Weiner D.J, Nehls M.C, Wilson J.M."	Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs.
DRAMP03369	QIINNPITCMTNGAICWGPCPTAFRQIGNCGHFKVRCCKIR	41	"Beta-defensin 4 (BD-4, mBD-4; Defensin, beta 4; Rodents, mammals, animals)"	P82019	Belongs to the beta-defensin family	Defb4	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Bridge	Not found	None	"PTM: Contains three disulfide bonds 9-37; 16-30; 20-38. When expressed as a fusion protein, mBD-4 showed activity against both E. coli and S. aureus at 1ug/ml as well as chemotactic activity via CCR6-expressing cells (Rohrl J et al. J Biol Chem. 2010 Mar 5;285(10):7028-34). "	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys9 and Cys37,Cys16 and Cys30,Cys20 and Cys38."	L	No cytotoxicity information found	Not found	10922379	J Biol Chem. 2000 Oct 27;275(43):33314-33320.	"Jia HP, Wowk SA, Schutte BC, Lee SK, Vivado A, Tack BF, Bevins CL, McCray PB Jr."	"A novel murine beta-defensin expressed in tongue, esophagus, and trachea."
DRAMP03373	NEPVSCIRNGGICQYRCIGLRHKIGTCGSPFKCCK	35	"Beta-defensin 8 (BD-8, mBD-8; Defensin, beta 8; Rodents, mammals, animals)"	"Q91V82, Q8R556"	Belongs to the beta-defensin family	Defb8	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine helix and strand structure	Not found	1E4R resolved by NMR.	"PTM: Contains three disulfide bonds 6-33; 13-27; 17-34.
Function: The antimicrobial activity against S. aureus, E. coli and B.cepacia is reduced in raised concentration of NaCl, but its action against Pseudomonas aeruginosa is independent of NaCl concentration."	"Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli, Burkholderia cepacia."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available##11714914	Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.##Protein Sci. 2001 Dec;10(12):2470-2479.	"Conejo-Garcia JR, Nehls MC, Wattler S, Bals R, Heitland A, Kluever E, Liepke C, Adermann K, Forssmann WG.##Bauer F, Schweimer K, Kl¨¹ver E, Conejo-Garcia JR, Forssmann WG, R?sch P, Adermann K, Sticht H."	"Cloning and characterization of mBD-7 and mBD-8, two novel mouse beta-defensins.##Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity."
DRAMP03393	IGPDTKKCVQRKNACHYFECPWLYYSVGTCYKGKGKCCQKRY	42	"Beta-defensin 38 (BD-38, mBD-38; Defensin, beta 38; Rodents, mammals, animals)"	Q7TNV7	Belongs to the beta-defensin family	Defb38	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Bridge	Not found	None	PTM: Contains three disulfide bonds 8-37; 15-30; 20-38.	"Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecium."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	14718547	J Biol Chem. 2004 Mar 26;279(13):12421-12426.	"Zaballos A, Villares R, Albar JP, Mart¨ªnez-A C, M¨¢rquez G."	Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ.
DRAMP03399	PGDIPPGIRNTVCLMQQGHCRLFMCRSGERKGDICSDPWNRCCVPYSVKDRR	52	"Sperm-associated antigen 11 (Rodents, mammals, animals)"	"Q8K4N2, Q2HPE4, Q30KM3"	Belongs to the beta-defensin family	Spag11	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram-"	Homology	Not found	Not found	None	"Is also responsible for sperm maturation, storage, and protection. "	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16033865##12193721	Physiol Genomics. 2005 Sep 21;23(1):5-17.##J Immunol. 2002 Sep 1;169(5):2516-2523.	"Patil A.A, Cai Y, Sang Y, Blecha F, Zhang G.##Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y."	Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.##Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.
DRAMP03400	GGVKGEEKRVCPPDYVRCIRQDDPQCYSDNDCGDQEICCFWQCGFKCVLPVKDNSEEQIPQSKV	64	"WAP four-disulfide core domain protein 12 (Rodents, mammals, animals)"	Q9JHY3	Not found	Wfdc12	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (IC90=10 ?M);##Gram-positive bacterium: Staphylococcus aureus (IC90=10 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12574366	J Immunol. 2003 Feb 15;170(4):1973-1979.	"Hagiwara K, Kikuchi T, Endo Y, Huqun, Usui K, Takahashi M, Shibata N, Kusakabe T, Xin H, Hoshi S, Miki M, Inooka N, Tokue Y, Nukiwa T."	Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif.
DRAMP03402	RPEIKKKNVFSKPGYCPEYRVPCPFVLIPKCRRDKGCKDALKCCFFYCQMRCVDPWESPE	60	"WAP four-disulfide core domain protein 15B (Elafin-like protein I; Rodents, mammals, animals)"	"Q9JHY4, A2A5M6, Q8BVC0"	Not found	Wfdc15b	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli (IC90=10 ?M);##Gram-positive bacterium: Staphylococcus aureus (IC90=10 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12574366	J Immunol. 2003 Feb 15;170(4):1973-1979.	"Hagiwara K, Kikuchi T, Endo Y, Huqun, Usui K, Takahashi M, Shibata N, Kusakabe T, Xin H, Hoshi S, Miki M, Inooka N, Tokue Y, Nukiwa T."	Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif.
DRAMP03407	DPVTYIRNGGICQYRCIGLRHKIGTCGSPFKCCK	34	"Defr1 (Murine beta-defensin related peptide; Rodents, mammals, animals)"	No entry found	Belongs to the beta-defensin family	Not found	Mus musculus (Mouse)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"The antimicrobial activity of Defr1 against S. aureus, E. coli, and B. cepacia was found to be reduced in raised concentration of NaCl, but its action against P. aeruginosa was independent of NaCl concentration. "	"Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli, Burkholderia cepacia."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12226710	Mamm Genome. 2002 Aug;13(8):445-451.	"Morrison GM, Rolfe M, Kilanowski FM, Cross SH, Dorin JR."	Identification and characterization of a novel murine beta-defensin-related gene.
DRAMP03408	VTCFCRRRGCASRERHIGYCRFGNTIYRLCCRR	33	"Neutrophil defensin 1 (HANP-1; alpha-defensin; Rodents, mammals, animals)"	P81465	Belongs to the alpha-defensin family	Not found	Mesocricetus auratus (Golden hamster)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Anti-fungal and bactericidal activity, greater against Gram-positive bacteria."	"Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis;##Gram-negative bacteria: Escherichia coli, Salmonella serotype krefeld, Klebsiella oxytoca, Pseudomonas aeruginosa.##Fungi: Candida albicans, Cryptococcus neoformans."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30."	L	No cytotoxicity information found	Not found	8890190	Infect Immun. 1996 Nov;64(11):4444-4449.	"Mak P, W¨®jcik K, Thogersen IB, Dubin A."	"Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins."
DRAMP03409	CFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ	31	"Neutrophil defensin 2 (HANP-2; alpha-defensin; Rodents, mammals, animals)"	P81466	Belongs to the alpha-defensin family	Not found	Mesocricetus auratus (Golden hamster)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Bactericidal activity, greater against Gram-positive bacteria. Low anti-fungi activity"	"Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis;##Gram-negative bacteria: Escherichia coli, Salmonella serotype krefeld, Klebsiella oxytoca, Pseudomonas aeruginosa.##Fungi: Candida albicans, Cryptococcus neoformans."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Cyclization(Cys1 and Cys29).	Free	"Disulfide bonds between Cys1 and Cys29,Cys3 and Cys18,Cys8 and Cys28."	L	No cytotoxicity information found	Not found	8890190	Infect Immun. 1996 Nov;64(11):4444-4449.	"Mak P, W¨®jcik K, Thogersen IB, Dubin A."	"Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins."
DRAMP03410	VTCFCRRRGCASRERLIGYCRFGNTIYGLCCRR	33	"Neutrophil defensin 3 (HANP-3; alpha-defensin; Rodents, mammals, animals)"	P81467	Belongs to the alpha-defensin family	Not found	Mesocricetus auratus (Golden hamster)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Anti-fungal and bactericidal activity, greater against Gram-positive bacteria."	"Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis;##Gram-negative bacteria: Escherichia coli, Salmonella serotype krefeld, Klebsiella oxytoca, Pseudomonas aeruginosa.##Fungi: Candida albicans, Cryptococcus neoformans."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30."	L	No cytotoxicity information found	Not found	8890190	Infect Immun. 1996 Nov;64(11):4444-4449.	"Mak P, W¨®jcik K, Thogersen IB, Dubin A."	"Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins."
DRAMP03411	VTCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ	33	"Neutrophil defensin 4 (HANP-4; alpha-defensin; Rodents, mammals, animals)"	P81468	Belongs to the alpha-defensin family	Not found	Mesocricetus auratus (Golden hamster)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Bactericidal activity, greater against Gram-positive bacteria. Low anti-fungi activity."	"Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis;##Gram-negative bacteria: Escherichia coli, Salmonella serotype krefeld, Klebsiella oxytoca, Pseudomonas aeruginosa.##Fungi: Candida albicans, Cryptococcus neoformans."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30."	L	No cytotoxicity information found	Not found	8890190	Infect Immun. 1996 Nov;64(11):4444-4449.	"Mak P, W¨®jcik K, Thogersen IB, Dubin A."	"Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins."
DRAMP03420	VTCYCRSTRCGFRERLSGACGYRGRIYRLCCR	32	"Neutrophil antibiotic peptide NP-2 (RatNP-2; Rodents, mammals, animals)"	Q62715	Belongs to the alpha-defensin family	Defa	Rattus norvegicus (Rat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus."	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Salmonella typhimurium.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30."	L	No cytotoxicity information found	Not found	2254017##7594610	Infect. Immun. 1990;58:3899-3902.##J. Immunol. 1995;155:4476-4484. 	"Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E."	Polymorphic expression of defensins in neutrophils from outbred rats.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis.
DRAMP03421	CSCRTSSCRFGERLSGACRLNGRIYRLCC	29	"Neutrophil antibiotic peptide NP-3 (RatNP-3a, RatNP-3b; Rodents, mammals, animals)"	"Q62713, Q9Z1F1"	Belongs to the alpha-defensin family	Not found	Rattus norvegicus (Rat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Protein level	Bridge	Not found	None	"Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus."	"Gram-positive bacterium: Staphylococcus aureus 502A;##Gram-negative bacterium: Escherichia coli ML-35.##Fungi: Candida albicans 820, Cryptococcus neoformans A-383."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Cyclization(Cys1 and Cys29).	Cyclization(Cys1 and Cys29).	"Disulfide bonds between Cys1 and Cys29,Cys3 and Cys18,Cys8 and Cys28."	L	No cytotoxicity information found	Not found	2254017##7594610	Infect. Immun. 1990;58:3899-3902.##J. Immunol. 1995;155:4476-4484. 	"Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E."	Polymorphic expression of defensins in neutrophils from outbred rats.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis.
DRAMP03423	DIPPGIRNTVCFMQRGHCRLFMCRSGERKGDICSDPWNRCCVSSSIKNR	49	"BIN1b (Sperm-associated antigen 11; Antimicrobial-like protein Bin-1b; Rodents, mammals, animals)"	Q8VBV2	Belongs to the beta-defensin family	Spag11	Rattus norvegicus (Rat)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Antimicrobial peptide against E.coli. Is also responsible for sperm maturation, storage, and protection.
Tissue specificity: Only expressed in epididymis (middle part of the caput).
Developmental stage: Its expression starts at 30 days of age, reaches a maximum during the sexually mature period, and then decreased in old rats.
PTM: Contains three disulfide bonds 11-40; 18-33; 23-41."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11230693	J Biotechnol. 2009 Jan 1;139(1):33-37##Science. 2001 Mar 2;291(5509):1783-1785.	"Guo C, Diao H, Lian Y, Yu H, Gao H, Zhang Y, Lin D.##Li P, Chan HC, He B, So SC, Chung YW, Shang Q, Zhang YD, Zhang YL."	Recombinant expression and characterization of an epididymis-specific antimicrobial peptide BIN1b/SPAG11E.##An antimicrobial peptide gene found in the male reproductive system of rats.
DRAMP03424	DQYRCLQNGGFCLRSSCPSHTKLQGTCKPDKPNCCRS	37	"Beta-defensin 1 (BD-1, RBD-1; Defensin, beta 1; Rodents, mammals, animals)"	O89117	Belongs to the beta-defensin family	Defb1	Rattus norvegicus (Rat)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Bridge	Not found	None	"Function Has antibacterial activity (By similarity).
PTM: Contains three disulfide bonds 5-34; 12-27; 17-35."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available##10456937	Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.##Infect Immun. 1999 Sep;67(9):4827-4833.	"Page R.A, Malik A.N.##Jia HP, Mills JN, Barahmand-Pour F, Nishimura D, Mallampali RK, Wang G, Wiles K, Tack BF, Bevins CL, McCray PB Jr."	Rat beta defensin-1 peptide: candidate marker for diabetic nephropathy.##Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins.
DRAMP03445	GVNMYIRQIYDTCWKLKGHCRNVCGKKEIFHIFCGTQFLCCIERKEMPVLFVK	53	"Beta-defensin 30 (BD-30, RBD-30; Defensin, beta 30; Rodents, mammals, animals)"	Q32ZG2	Belongs to the beta-defensin family	Defb30	Rattus norvegicus (Rat)	"Antimicrobial, Antibacterial, Anti-Gram-"	Homology	Bridge	Not found	None	"Function Has antibacterial activity (By similarity).
PTM: Contains three disulfide bonds 13-40; 20-34; 24-41."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16033865	Physiol Genomics. 2005 Sep 21;23(1):5-17.	"Patil AA, Cai Y, Sang Y, Blecha F, Zhang G."	Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
DRAMP03470	GFGCPWNRYQCHSHCRSIGRLGGYCAGSLRLTCTCYRS	38	"Defensin-1 (American oyster defensin, AOD; molluscs, animals)"	P85008	Belongs to the invertebrate defensin family (Type 2 subfamily)	Not found	Crassostrea virginica (American oyster) 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	PTM: Contains three disulfide bond: 4-25; 11-33; 15-35.	"Gram-positive bacteria: Lactococcus lactis subsp. lactis (MECs=2.4 ?g/ml), Staphylococcus aureus (MECs=3 ?g/ml);##Gram-negative bacteria: Escherichia coli D31 (MECs=7.6 ?g/ml), Vibrio parahaemolyticus (MECs=15 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16297885	Biochem Biophys Res Commun. 2005 Dec 30;338(4):1998-2004.	"Seo JK, Crawford JM, Stone KL, Noga EJ."	"Purification of a novel arthropod defensin from the American oyster, Crassostrea virginica."
DRAMP03491	YDNVNLDEILANDRLLVPYIKCLLDEGKKAPDAKELKEHIRXAL	44	"Viresin (Insects, animals)"	P86354	Not found	Not found	Heliothis virescens (Tobacco budworm moth)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity against the Gram-negative bacteria E. coli and E. cloacae, but not against the Gram-negative bacteria P. aeruginosa, P. vulgaris, K. pneumoniae and S. enteritidis or the Gram-positive bacteria S. aureus, S. epidermidis and S. salivarius."	"Gram-negative bacteria: E. coli K12 D31, E. coli and E. cloacae."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651803	Eur J Biochem. 2000 Feb;267(3):677-683.	Viresin. A novel antibacterial protein from immune hemolymph of Heliothis virescens pupae.	Viresin. A novel antibacterial protein from immune hemolymph of Heliothis virescens pupae.
DRAMP03501	AIGCNTVASKMAPCLPYVTGKGPLGGCCGGVKGLIDAARTTPDRQAVCNCLKTLAKSYSGINLGNAAGLPGKCGVSIPYQISPNTDCSKVH	91	"La-LTP (LJAFP; Insects, animals)"	Q52RN7	Not found	Afp	Leonurus japonicus (Chinese motherwort) (Leonurus artemisia)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).	"Gram-positive Bacteria: Bacillus subtilis (IC50>15 ?M). ##Gram-negative Bacteria: Pseudomonas solanacearum (IC50=7.5-15 ?M), Ralstonia solanacearum (IC50=15 ?M).##Fungi: Alternaria alternate (IC50<7.5 ?M), Alternaria brassicae (IC50<7.5 ?M), Aspergillus niger (IC50<7.5 ?M), Bipolaris maydis (IC50<7.5 ?M), Botrytis cinerea (IC50=7.5-15 ?M), Cerospora personata (IC50=7.5-15 ?M), Colletotrichum gloeosporiodes (IC50<7.5 ?M), Fusarium graminearum (IC50=7.5-15 ?M), Fusarium oxysporum (IC50=7.5-15 ?M), Penicillium digitatum (IC50>15 ?M), Pyricularia grisea (IC50=7.5-15 ?M), Rhizoctonia solani (IC50<7.5 ?M), Rhizoctonia cerealis (IC50=7.5-15 ?M), Saccharomyces cerevisiae (IC50>15 ?M), Sclerotinia sclerotiorum (IC50>15 ?M), Trichoderma harzianum (IC50=7.5-15 ?M), Verticillium dahliae (IC50=7.5-15 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipid-binding	PubMed ID is not available	Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases	"Yang X, Xiao Y, Pei Y, Zhen C."	"LJAFP, a novel non-specific lipid transfer protein-like antimicrobial protein from motherwort (Leonurus japonicus) confers disease resistance against phytopathogenic fungi and bacterium in transgenic tobacco."
DRAMP02962	GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLGCG	36	PMAP-36	P49931 	Belongs to the cathelicidin family	PMAP36	Sus scrofa 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Alpha helix	PMAP-36 contains a typical 	None	"Function: Antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteria and Fungi. Has hemolytic activity."	"[Ref.27251456] Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=2 ¦ÌM, MBC=4 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM, MBC=4 ¦ÌM), Staphylococcus epidermidis 12228 (MIC=2 ¦ÌM, MBC=4 ¦ÌM), Bacillus subtilis 63501 (MIC=1 ¦ÌM, MBC=1 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=1 ¦ÌM, MBC=4 ¦ÌM), Escherichia coli EC183 (MIC=1 ¦ÌM, MBC=1 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM, MBC=2 ¦ÌM), Salmonella typhimurium C77-31 (MIC=1 ¦ÌM, MBC=2 ¦ÌM);##Fungi: Candida albicans 2.2086 (MIC=128 ¦ÌM, MFC=128 ¦ÌM), Candida albicans CA276 (MIC=128 ¦ÌM, MFC=128 ¦ÌM), Candida tropicalis 2.1975 (MIC=1 ¦ÌM, MFC=2 ¦ÌM), Candida krusei 2.1857 (MIC=8 ¦ÌM, MFC=8 ¦ÌM)."	"[Ref.27251456] 5% hemolysis at 4 ?M, MHC=4 ?M against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27251456	Sci Rep. 2016 Jun 2;6:27258. 	"Lyu Y, Yang Y, Lyu X, Dong N, Shan A."	"Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida."
DRAMP03511	KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL	35	"Cecropin-B (Immune protein P9; Insects, animals)"	P01508	Belongs to the cecropin family	Not found	Hyalophora cecropia (Cecropia moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli D21 (MLC=0.32 ?M), Escherichia coli D31 (MLC=0.32 ?M), Serratia marcescens Db11 (MLC=4.5 ?M), Serratia marcescens Db1108 (MLC=2.4 ?M), Serratia marcescens Db1121 (MLC=2.2 ?M), Serratia marcescens Strain 122 (MLC=2.9 ?M), Pseudomonas aeruginosa OT97 (MLC=1.9 ?M), Xenorhabdus nematophilus Xn21 (MLC=1.6 ?M);##Gram-positive bacteria: Bacillus megaterium Bmll (MLC=0.44 ?M), Bacillus subtilis Bs11 (MLC=18 ?M), B.thuringiensis Bt11 (MLC>133 ?M), Streptococcus fecalis AD-4 (MLC=7.3 ?M), Streptococcus fecalis DS16 (MLC>24 ?M), Micrococcus luteus M111 (MLC=1.3 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7140755	Eur J Biochem. 1982 Sep;127(1):207-217.	"Hultmark D, Engstr?m A, Bennich H, Kapur R, Boman HG."	Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae.
DRAMP03512	WNPFKELEKVGQRVRDAVISAGPAVATVAQATALAK	36	"Cecropin-D (Cecropin D; Insects, animals)"	P01510	Belongs to the cecropin family	Not found	Hyalophora cecropia (Cecropia moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli D21 (LC=0.43 ?M), Escherichia coli D31 (LC=0.40 ?M), Serratia marcescens Db11 (LC=14 ?M), Serratia marcescens Db1108 (LC=12 ?M), Serratia marcescens Db1121 (LC=12 ?M), Strain 122 (LC=19 ?M), Pseudomonas aeruginosa OT97 (LC=100 ?M), Xenorhabdus nematophilus Xn21 (LC=19 ?M);##Gram-positive bacteria: Bacillus megaterium Bmll (LC=41 ?M), Bacillus subtilis Bs11 (LC>95 ?M), B.thuringiensis Bt11 (LC>95 ?M), Streptococcus fecalis AD-4 (LC>95 ?M), Streptococcus fecalis DS16 (LC=88 ?M), Micrococcus luteus M111 (LC=21 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7140755##1711035	Eur J Biochem. 1982 Sep;127(1):207-217.##J Biol Chem. 1991 Jun 25;266(18):11510-11517.	"Hultmark D, Engstr?m A, Bennich H, Kapur R, Boman HG.##Gudmundsson GH, Lidholm DA, Asling B, Gan R, Boman HG."	Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae.##The cecropin locus. Cloning and expression of a gene cluster encoding three antibacterial peptides in Hyalophora cecropia.
DRAMP03534	PWNIFKEIERAVARTRDAVISAGPAVRTVAAATSVAS	37	"Antibacterial peptide enbocin (Moricin; Insects, animals)"	P48821	Belongs to the cecropin family	Not found	Bombyx mori (Silk moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Homology	Not found	Not found	None	Function: Has antibacterial activity against Gram-positive and Gram-negative bacteria.	"Gram-positive bacteria: Bacillus subtilis, Bacillus thuringiensis, Staphyllococcus aureus;##Gram-negative bacteria: Psedomonas solanacearum, Salmonellar typhimurium, Escherichia coli."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9610369	Biochem Biophys Res Commun. 1998 May 19;246(2):388-392.	"Kim SH, Park BS, Yun EY, Je YH, Woo SD, Kang SW, Kim KY, Kang SK."	"Cloning and expression of a novel gene encoding a new antibacterial peptide from silkworm, Bombyx mori."
DRAMP03535	DLRFLYPRGKLPVPTPPPFNPKPIYIDMGNRY	32	"Lebocin-1/2 (Pro-rich; Insects, animals)"	P54684	Belongs to the lebocin family	Not found	Bombyx mori (Silk moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Rich	Not found	None	"Function: Antibacterial peptide.
Tissue specificity: Hemolymph. Produced in fat body.
Induction: By bacterial infection.
PTM: O-glycosylation is important for the antibacterial activity of lebocin, O-linked glycan structure is a disaccharide (Gal-GalNAc) in case of lebocin 1 and a monosaccharide (GalNAc) in case of lebocin 2."	"Gram-negative bacteria: Acinetobacter sp. NISL B-4653, Escherichia coli HB1ll, Pseudomonas fluorescens IAM1179;##Gram-positive bacterium: Staphylococcus aureus ATCC6538P."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7654207##7545395	Biochem J. 1995 Sep 1;310 (Pt 2):651-656.##Biochem Biophys Res Commun. 1995 Sep 5;214(1):271-278. 	"Hara S, Yamakawa M.##Chowdhury S, Taniai K, Hara S, Kadono-Okuda K, Kato Y, Yamamoto M, Xu J, Choi SK, Debnath NC, Choi HK, et al."	"A novel antibacterial peptide family isolated from the silkworm, Bombyx mori.##cDNA cloning and gene expression of lebocin, a novel member of antibacterial peptides from the silkworm, Bombyx mori."
DRAMP03536	DLRFLYPRGKLPVPTLPPFNPKPIYIDMGNRY	32	"Lebocin-3 (LEB 3; Insects, animals)"	P55796	Belongs to the lebocin family	LEB3	Bombyx mori (Silk moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	A unique threonine residue in each peptide was O-glycosylated and the modification seemed to be important for expression of antibacterial activity. 	None	Function: Antibacterial peptide.	"Gram-negative bacteria: Acinetobacter sp. NISL B-4653, Escherichia coli HB1ll, Pseudomonas fluorescens IAM1179;##Gram-positive bacterium: Staphylococcus aureus ATCC 6538P."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	7654207##9325165	Biochem J. 1995 Sep 1;310 (Pt 2):651-656.##Biochem Biophys Res Commun. 1997 Sep 29;238(3):769-774.	"Hara S, Yamakawa M.##Furukawa S, Taniai K, Ishibashi J, Hara S, Shono T, Yamakawa M."	"A novel antibacterial peptide family isolated from the silkworm, Bombyx mori.##A novel member of lebocin gene family from the silkworm, Bombyx mori."
DRAMP03554	ASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKV	67	"CCL20(1-67) (Human, mammals, animals)"	P78556	Belongs to the intercrine beta (chemokine CC) family	CCL20	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge (2 disulfide bonds)	Not found	None	"Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E. coli ATCC 25922 and S. aureus ATCC 29213."	"Gram-negative bacterium: Escherichia coli ATCC 25922,##Gram-positive bacterium: Staphylococcus aureus ATCC 29213."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12149255	J Biol Chem. 2002 Oct 4;277(40):37647-54.	"Hoover DM, Boulegue C, Yang D, Oppenheim JJ, Tucker K, Lu W, Lubkowski J."	The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
DRAMP03555	SNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM	69	"CCL20(2-70) (Human, mammals, animals)"	P78556	Belongs to the intercrine beta (chemokine CC) family	CCL20	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge (2 disulfide bonds)	Not found	None	"Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E. coli ATCC 25922 and S. aureus ATCC 29213."	"Gram-negative bacterium: Escherichia coli ATCC 25922,##Gram-positive bacterium: Staphylococcus aureus ATCC 29213."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12149255	J Biol Chem. 2002 Oct 4;277(40):37647-54.	"Hoover DM, Boulegue C, Yang D, Oppenheim JJ, Tucker K, Lu W, Lubkowski J."	The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
DRAMP03556	ASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM	70	"C-C motif chemokine 20 (Human, mammals, animals)"	P78556	Belongs to the intercrine beta (chemokine CC) family	CCL20	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E. coli ATCC 25922 and S. aureus ATCC 29213.	"Gram-negative bacterium: Escherichia coli ATCC 25922,##Gram-positive bacterium: Staphylococcus aureus ATCC 29213."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12149255	J Biol Chem. 2002 Oct 4;277(40):37647-54.	"Hoover DM, Boulegue C, Yang D, Oppenheim JJ, Tucker K, Lu W, Lubkowski J."	The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
DRAMP03564	ICIFCCGCCHRSKCGMCCKT	20	"Human hepcidin-20 (Hepc20; one chain of Hepcidin; Human, mammals, animals)"	"P81172, Q1HE14, Q9BY68"	Not found	HAMP	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand	Not found	1M4E resolved by NMR.	"Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.
PTM: Contains four disulfide bonds 2-18; 5-17; 6-14; 8-9."	"Gram-negative bacterium: Escherichia coli;##Gram-positive bacteria: Staphylococcus aureus, S. epidermidis, group B Streptococcus.##Fungi: Candida albicans, Aspergillus fumigatus, Aspergillus niger."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11113131##12138110##11034317	J Biol Chem. 2001 Mar 16;276(11):7806-7810.##J Biol Chem. 2002 Oct 4;277(40):37597-37603.##FEBS Lett. 2000 Sep 1;480(2-3):147-150.	"Park CH, Valore EV, Waring AJ, Ganz T.##Hunter HN, Fulton DB, Ganz T, Vogel HJ.##Krause A et al Adermann K."	"Hepcidin, a urinary antimicrobial peptide synthesized in the liver.##The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis.##LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. ref2) Hepcidin, a rinary antimicrobial peptide synthesized in the liver."
DRAMP03565	DTHFPICIFCCGCCHRSKCGMCCKT	25	"Human hepcidin-25 (Hepc25; one chain of Hepcidin; Human, mammals, animals)"	"P81172, Q1HE14, Q9BY68"	Not found	HAMP	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Beta strand	N-terminus is a metal-binding site. disulfide bonds are essential for antibacterial activity by probably binding to DNA.	"1M4F, 2KEF resolved by NMR.##3H0T resolved by X-ray."	"PTM: Contains four disulfide bonds 7-22; 10-13; 11-19; 14-22.
Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.
Function: It showed antimicrobial activities in vitro, this peptide might be the long-sought hormone that regulates iron homeostasis in humans. A pathogen will survive if it can figure out a way to steal iron from the host."	"Gram-negative bacterium: Escherichia coli;##Gram-positive bacteria: Staphylococcus aureus, S. epidermidis, group B Streptococcus.##Fungi: Candida albicans, Aspergillus fumigatus, Aspergillus niger."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	DNA	11034317##11113131##12138110##19553669	FEBS Lett. 2000 Sep 1;480(2-3):147-150.##J Biol Chem. 2001 Mar 16;276(11):7806-7810.##J Biol Chem. 2002 Oct 4;277(40):37597-37603.##J Biol Chem. 2009 Sep 4;284(36):24155-24167.	"Krause A et al Adermann K.##Park CH, Valore EV, Waring AJ, Ganz T.##Hunter HN, Fulton DB, Ganz T, Vogel HJ.##Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ."	"LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. ref2) Hepcidin, a rinary antimicrobial peptide synthesized in the liver.##Hepcidin, a urinary antimicrobial peptide synthesized in the liver.##The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis.##Hepcidin revisited, disulfide connectivity, dynamics, and structure."
DRAMP03566	MHDFWVLWVLLEYIYNSACSVLSATSSVSSRVLNRSLQVKVVKITN	46	"Salvic (Human, mammals, animals)"	No entry found	Not found	Not found	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	J Hard Tissue Biol 2005; 14: 258-260.	Kim YS et al Chung SI.	"Cloning and identification of a new antimicrobial peptide, salvic, from human salivary gland."
DRAMP03585	AELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDES	68	"Human TC-1 (Chain of Platelet basic protein; Human, mammals, animals)"	"P02775, B2R5F3, Q6IBJ8"	Not found	PPBP	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Combine helix and strand structure	Not found	1TVX resolved by X-ray.	PTM: Contains two disulfide bonds 5-31; 7-46.	"Gram-positive bacteria: Bacillus subtilis (MBC=0.4 ?M), Staphylococcus aureus (MBC=6.8 ?M);##Gram-negative bacterium: Escherichia coli (MBC=3.4 ?M).##Fungi: Cryptococcus neoformans (MFC=1.9 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10877842##8034022	J Biol Chem. 2000 Jul 7;275(27):20374-20381.##FEBS Lett. 1994 Jun 27;347(2-3):300-303.	"Krijgsveld J, Zaat SA, Meeldijk J, van Veelen PA, Fang G, Poolman B, Brandt E, Ehlert JE, Kuijpers AJ, Engbers GH, Feijen J, Dankert J.##Kungl AJ, Machius M, Huber R, Schwer C, Lam C, Aschauer H, Ehn G, Lindley IJ, Auer M."	"Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines.##Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP-2)."
DRAMP03586	NLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDES	83	"Human TC-2 (Chain of Platelet basic protein; Human, mammals, animals)"	"P02775, B2R5F3, Q6IBJ8"	Not found	PPBP	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Combine helix and strand structure	Not found	1F9P resolved by X-ray.	PTM: Contains two disulfide bonds 19-46; 22-62.	"Gram-positive bacteria: Bacillus subtilis ATCC6633 (MBC=0.7 ?M), Staphylococcus aureus 42D (MBC=11 ?M);##Gram-negative bacterium: Escherichia coli ML35 (MBC=2.7 ?M).##Fungi: Cryptococcus neoformans (MFC=30 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10877842##8034022	J Biol Chem. 2000 Jul 7;275(27):20374-20381.##FEBS Lett. 1994 Jun 27;347(2-3):300-303.	"Krijgsveld J, Zaat SA, Meeldijk J, van Veelen PA, Fang G, Poolman B, Brandt E, Ehlert JE, Kuijpers AJ, Engbers GH, Feijen J, Dankert J.##Kungl AJ, Machius M, Huber R, Schwer C, Lam C, Aschauer H, Ehn G, Lindley IJ, Auer M."	"Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines.##Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP-2)."
DRAMP03587	SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSV	47	"DCD-1 (chain of Dermcidin; Human, mammals, animals)"	"P81605, A5JHP2, A5JHP3, P58461, Q53YJ2"	Not found	DCD	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Proteolytic"	Protein level	Alpha helix 	"Structural analysis of dermcidin-1L in 50% TFE using an N15-labeled recombinant peptide reveals a long helix-hinge-helix motif, allowing it to associate with bacterial membranes (Jung et al. 2010 BMB Rep. 43: 362-8). "	2KSG resolved by NMR.##2YMK resolved by X-ray.	"Function: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. Survival-promoting peptide promotes survival of neurons and displays phosphatase activity.
Catalytic activity: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
Cofactor: Manganese. Required for survival-promoting peptide.
Tissue specificity: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml."	"Gram-negative bacteria: Escherichia coli, Enterococcus faecalis;##Gram-positive bacterium: Staphylococcus aureus.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	May bind IgG	11694882##17448443##20510021	Nat Immunol. 2001 Dec;2(12):1133-1137.##Biochem Biophys Res Commun. 2007 Jun 15;357(4):828-833.##BMB Rep. 2010 May;43(5):362-368.	"Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, Schirle M, Schroeder K, Blin N, Meier F, Rassner G, Garbe C.##Lee Motoyama JP, Kim-Motoyama H, Kim P, Nakagama H, Miyagawa K, Suzuki K.##Jung HH, Yang ST, Sim JY, Lee S, Lee JY, Kim HH, Shin SY, Kim JI."	Dermcidin: a novel human antibiotic peptide secreted by sweat glands.##Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity.##Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles.
DRAMP03588	LAHQKPFIRKSYKCLHKRCR	20	"Human MUC7 20-Mer (Human, mammals, animals)"	No entry found	Not found	Not found	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix 	Not found	None	"Function: MUC7 20-mer showes potent activity against a variety of fungi, including C. albicans, C. glabrata, C. krusei, C. neoformans, and S. cerevisae. In addition, it is also active against several drug-resistant strains, including azole-resistant C. albicans, fluconazole-resistant C. glabrata, and amphotericin B-resistant C. neoformans."	"Gram-positive bacteria: Streptococcus mutans (EC50=1.39 ?M), Streptococcus gordonii (EC50=2.43 ?M);##Gram-negative bacteria: Escherichia coli (EC50=1.61 ?M), Pseudomonas aeruginosa (EC50=4.41 ?M), Porphyromonas gingivalis (EC50<1 ?M).##Fungi: Candida albicans (DIS) (EC50=5.85 ?M), C. albicans (azole resistant) (EC50=2.40 ?M), Candida glabrata (EC50=5.02 ?M), C. glabrata (fluconazole resistant) (EC50=12.3 ?M), Candida krusei (EC50=5.16 ?M), Cryptococcus neoformans (EC50=4.05 ?M), Cryptococcus neoformans (amphotericin B resistant) (EC50=4.29 ?M), Saccharomyces cerevisiae (EC50=5.23 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12543672	Antimicrob Agents Chemother 2003 Feb;47(2):643-652.	"Bobek LA, Situ H."	"MUC7 20-Mer: Investigation of Antimicrobial Activity, Secondary Structure, and Possible Mechanism of Antifungal Action."
DRAMP03591	ACYCRIPACIAGERRYGTCIYQGRLWAFCC	30	"Neutrophil defensin 1 (Defensin, alpha 1; HNP-1, HP-1; Human, mammals, animals)"	"P59665, P11479, Q14125, Q6EZF6"	Belongs to the alpha-defensin family	"DEFA1, DEFA1B"	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)"	Protein level	Beta strand	"Compared to HNP-2, HNP-1 contains one additional residue (Ala) at the N-terminus. It contains a long stretch of a double-stranded antiparallel beta-sheet in a hairpin conformation that contains a beta-bulge, a short region of triple-stranded beta-sheet, and several tight turns."	2KHT resolved by NMR	"Function: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
PTM: ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production. Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-rybosylation."	"[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(approximately 50% inbibition at 1 ¦Ìg/mL (290 nM));SARS-CoV-2 variant P.1:inhibition of infection in HeLa-hACE2 cells(67% inbibition at 50 ¦Ìg/mL);SARS-CoV-2 variant B.1.1.7:inhibition of infection in HeLa-hACE2 cells(58% inbibition at 50 ¦Ìg/mL).##[Ref.15616305] Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=3.6¡À0.3 ¦Ìg/ml), E. coli ATCC 25922 (vLD50=3.7¡À0.4 ¦Ìg/ml), Enterobacter aerogenes ATCC 13048 (vLD50=10¡À0.5 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=4.2¡À1.0 ¦Ìg/ml), Staphylococcus aureus ATCC 29213 (vLD50=2.1¡À0.3 ¦Ìg/ml), Bacillus cereus ATCC 10876 (vLD50=0.22¡À0.03 ¦Ìg/ml).##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s).##[Ref.15118082]Gram-positive bacteria: Bacillus subtilis (Inhibition zone=24 mm in PH5.5, Inhibition zone=20 mm in PH7.5 completely inhibit at 10 ¦Ìg/well), Staphylococcus aureus  (Inhibition zone=1 mm in PH5.5, Inhibition zone=7 mm incompletely inhibit and Inhibition zone=2 mm completely inhibit in PH7.5 at 10 ¦Ìg/well);##Gram-negative bacteria: Escherichia coli (Inhibition zone=5 mm incompletely inhibit and Inhibition zone=2 mm completely inhibit in PH7.5 at 10 ¦Ìg/well);##Fungi: Candida albicans (Inhibition zone=13 mm in PH5.5, Inhibition zone=10 mm in PH7.5 completely inhibit at 10 ¦Ìg/well)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization(Cys2 and Cys30).	"Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29."	L	[Ref.34206990]No cytotoxicity on HEK293T cells up to 50 ¦Ìg/mL.	Not found	34206990##19253295##15616305##15118082	Viruses. 2021 Jun 26;13(7):1246.##Proteomics. 2009 Mar;9(5):1364-1373.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.##Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.	"Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Stegemann C, Kolobov A Jr, Leonova YF, Knappe D, Shamova O, Ovchinnikova TV, Kokryakov VN, Hoffmann R.##Ericksen B, Wu Z, Lu W, Lehrer RI.##Yount NY, Yeaman MR."	"Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Isolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles.##Antibacterial activity and specificity of the six human {alpha}-defensins.##Multidimensional signatures in antimicrobial peptides."
DRAMP03592	CYCRIPACIAGERRYGTCIYQGRLWAFCC	29	"Neutrophil defensin 2 (HNP-2, HP-2, HP2; Human, mammals, animals)"	"P59665, P11479, Q14125, Q6EZF6, P59666, P11479, Q14125"	Belongs to the alpha-defensin family	DEFA1 AND DEFA1B	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)"	Protein level	Beta strand	Not found	"1ZMH, 1ZMI, 1ZMK resolved by X-ray."	"Function: Defensin 2 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
PTM: Contains three disulfide bonds 1-29; 3-18; 8-28."	"[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(approximately 50% inbibition at 1 ¦Ìg/mL (290 nM)).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=3.5¡À0.79 ?g/ml), E. coli ATCC 25922 (vLD50=3.5¡À0.6 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=16¡À4.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=4.2¡À0.9 ?g/ml), S. aureus ATCC 29213 (vLD50=2.4¡À0.3 ?g/ml), Bacillus cereus ATCC 10876 (vLD50=0.22¡À0.04 ?g/ml).(Ref.2)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys1 and Cys29,Cys3 and Cys18,Cys8 and Cys28."	L	No cytotoxicity information found in the reference(s) presented	Not found	34206990##15616305##15894545	Viruses. 2021 Jun 26;13(7):1246.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.##J Biol Chem. 2005 Sep 23;280(38):32921-9.	"Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Ericksen B, Wu Z, Lu W, Lehrer RI.##Xie C, Prahl A, Ericksen B, Wu Z, Zeng P, Li X, Lu WY, Lubkowski J, Lu W."	Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Antibacterial activity and specificity of the six human {alpha}-defensins.##Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
DRAMP03593	DCYCRIPACIAGERRYGTCIYQGRLWAFCC	30	"Neutrophil defensin 3 (Defensin, alpha 3; HNP-3, HP-3, HP3; Human, mammals, animals)"	"P59666, P11479, Q14125"	Belongs to the alpha-defensin family	DEFA3	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)"	Protein level	Beta strand	"Compared to HNP-2, HNP-3 contains one additional residue (Asp) at the N-terminus. The 3D structures remain the same. "	"1DFN, 2PM4, 2PM5 resolved by X-ray."	"Function: Defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
PTM: Contains three disulfide bonds 2-30; 4-19; 9-29."	"[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(approximately 50% inbibition at 1 ¦Ìg/mL (290 nM)).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=6.2¡À0.9 ?g/ml), E. coli ATCC 25922 (vLD50=5.9¡À2.1 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=41¡À9.2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=13¡À2.1 ?g/ml), S. aureus ATCC 29213 (vLD50=2.2¡À0.4 ?g/ml), Bacillus cereus ATCC 10876 (vLD50=0.37¡À0.08 ?g/ml).(Ref.2)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization(Cys2 and Cys30).	"Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29."	L	No cytotoxicity information found in the reference(s) presented	Not found	34206990##4056036##15616305	Viruses. 2021 Jun 26;13(7):1246.##J Clin Invest. 1985 Oct;76(4):1436-1439.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.	"Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI.##Ericksen B, Wu Z, Lu W, Lehrer RI."	Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Primary structures of three human neutrophil defensins.##Antibacterial activity and specificity of the six human {alpha}-defensins.
DRAMP03594	VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV	33	"Neutrophil defensin 4 (Defensin, alpha 4; HNP-4, HP-4; Human, mammals, animals)"	P12838	Belongs to the alpha-defensin family	DEFA4	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)"	Protein level	Beta strand	"Compared to HNP-2, HNP-1 contains one additional residue (Ala) at the N-terminus. It contains a long stretch of a double-stranded antiparallel beta-sheet in a hairpin conformation that contains a beta-bulge, a short region of triple-stranded beta-sheet, and several tight turns."	1ZMM resolved by X-ray.	"Function: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). In comparison with HNP1-3, inhibition of both strains of HIV-1 by HNP4 was noticeably stronger as evidenced by lower IC50 values (2-5 ?M) and steeper and more complete inhibition curves.
PTM: Contains three disulfide bonds 2-30; 4-19; 9-29."	"[Ref.34206990]Virus:showed inhibition against SARS-CoV-2.Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=3.3¡À0.4 ?g/ml), E. coli ATCC 25922 (vLD50=3.0¡À0.7 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=6.6¡À0.2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=7.3¡À1.4 ?g/ml), S. aureus ATCC 29213 (vLD50=7.2¡À0.2 ?g/ml), Bacillus cereus ATCC 10876 (vLD50=0.87¡À0.08 ?g/ml).(Ref.4)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s).##Yeast: Candida albicans ATCC 99788 amphotericin B resistant (IC90>100 ?g/ml).(Ref.2)"	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29."	L	No cytotoxicity information found in the reference(s) presented	Not found	34206990##17088326##15620707##15616305	Viruses. 2021 Jun 26;13(7):1246.##Protein Sci. 2006 Dec;15(12):2749-2760.##FEBS Lett. 2005 Jan 3;579(1):162-166.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.	"Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J.##Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, Lehrer RI, Lu W.##Ericksen B, Wu Z, Lu W, Lehrer RI."	"Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Crystal structures of human alpha-defensins HNP4, HD5, and HD6.##Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.##Antibacterial activity and specificity of the six human {alpha}-defensins."
DRAMP03595	ATCYCRTGRCATRESLSGVCEISGRLYRLCCR	32	"Human defensin-5 (HD-5; Defensin, alpha 5; Human, mammals, animals)"	"Q01523, A0JDY6, Q3KNV2"	Belongs to the alpha-defensin family	DEFA5	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)"	Protein level	Beta strand	The L- and D-forms of HD-5 are equally active than E.coli but not S. aureus (Wei G et al 2009 JBC 284: 29180-92). 	1ZMP resolved by X-ray.	"Function: Antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.
Tissue specificity: Paneth cells of the small intestine (at protein level).
PTM: Contains three disulfide bonds."	"[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(60% inhibition at 12.5 ¦Ìg/mL (3.45 ¦ÌM));SARS-CoV-2 variant P.1:inhibition of infection in HeLa-hACE2 cells(72% inbibition at 50 ¦Ìg/mL);SARS-CoV-2 variant B.1.1.7:inhibition of infection in HeLa-hACE2 cells(32% inbibition at 50 ¦Ìg/mL).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=2.5¡À0.3 ?g/ml), E. coli ATCC 25922 (vLD50=2.1¡À0.9 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=5.5¡À0.5 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=6.3¡À0.5 ?g/ml), S. aureus ATCC 29213 (vLD50=3.2¡À0.3 ?g/ml), Bacillus cereus ATCC 10876 (vLD50<0.31 ?g/ml).(Ref.2)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s)."	[Ref.26206286] It has 0% hemolysis at 100¦ÌM against human red blood cells.	Cyclic	Free	Free	"Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30."	L	[Ref.34206990]No cytotoxicity on HEK293T cells up to 50 ¦Ìg/mL.	Not found	34206990##12021776##15616305##26206286	Viruses. 2021 Jun 26;13(7):1246.##Nat Immunol. 2002 Jun;3(6):583-590.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.##Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.	"Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL.##Ericksen B, Wu Z, Lu W, Lehrer RI.##Basil Mathew Ramakrishnan Nagaraj"	Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Paneth cell trypsin is the processing enzyme for human defensin-5.##Antibacterial activity and specificity of the six human {alpha}-defensins.##Antimicrobial activity of human  -defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs
DRAMP03596	AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL	32	"Human defensin-6 (HD-6; Defensin, alpha 6; Human, mammals, animals)"	Q01524	Belongs to the alpha-defensin family	DEFA6	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)"	Protein level	Beta strand (3 strands; 19 residues)	Not found	"1ZMQ, 3QTE resolved by X-ray."	"Function: Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
Subunit structure: Homodimer.
Tissue specificity: Paneth cells of the small intestine.
PTM: Contains three disulfide bonds."	"[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(HD6 only blocked SARS-CoV-2 infection at the highest concentration tested (50 ¦Ìg/mL, 13 ¦ÌM)).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50>256 ?g/ml), E. coli ATCC 25922 (vLD50=103¡À14 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=156¡À11 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50>256 ?g/ml), S. aureus ATCC 29213 (vLD50>256 ?g/ml), Bacillus cereus ATCC 10876 (vLD50=25¡À13 ?g/ml).(Ref.3)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys4 and Cys31,Cys6 and Cys20,Cys10 and Cys30."	L	[Ref.34206990]No cytotoxicity on HEK293T cells up to 50 ¦Ìg/mL.	Not found	34206990##8417977##17088326##15616305	Viruses. 2021 Jun 26;13(7):1246.##FEBS Lett. 1993; 315:187-192.##Protein Sci. 2006 Dec;15(12):2749-2760.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.	"Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Jones DE, Bevins CL.##Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J.##Ericksen B, Wu Z, Lu W, Lehrer RI."	"Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel.##Crystal structures of human alpha-defensins HNP4, HD5, and HD6.##Antibacterial activity and specificity of the six human {alpha}-defensins."
DRAMP03601	WYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKGRDCCVPAD	42	"Human beta-defensin 26 (hBD-26; hBD26; Human, mammals, animals)"	No entry found	Belongs to the beta-defensin family	Not found	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Bridge 	Not found	None	Function: Both hBD26 and hBD27 showe salt-sensitive antimicrobial activity against gram-negative E. coli but not against gram-positive S. aureus and S. cerevisiae.	Gram-negative bacterium: Escherichia coli K12.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19373462	Appl Microbiol Biotechnol. 2009 Aug;84(2):301-308.	"Huang L, Leong SS, Jiang R."	Soluble fusion expression and characterization of bioactive human beta-defensin 26 and 27.
DRAMP03602	QLKKCWNNYVQGHCRKICRVNEVPEALCENGRYCCLNIKELEAC	44	"Human beta-defensin 27 (hBD-27; hBD27; Human, mammals, animals)"	No entry found	Belongs to the beta-defensin family	Not found	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Bridge 	Not found	None	Function: Both hBD26 and hBD27 showe salt-sensitive antimicrobial activity against gram-negative E. coli but not against gram-positive S. aureus and S. cerevisiae.	Gram-negative bacterium: Escherichia coli K12.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19373462	Appl Microbiol Biotechnol. 2009 Aug;84(2):301-308.	"Huang L, Leong SS, Jiang R."	Soluble fusion expression and characterization of bioactive human beta-defensin 26 and 27.
DRAMP18202	LIGSLFRGAKAIFRGARQGWRSHKAVSRYRARYVRRPVIYYHRVYP	46	"WB Piscidin 5 (fish, animals)"	E3UVF7(Precursor)	Belongs to the defensin family	Not found	Morone chrysops	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic"		Not found	Not found	None	No more comments	Staphylococcus aureus ATCC 29213(MIC 4.52uM)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipid-binding	27552222	PLoS One. 11(8):e0159423(2016)	"Salger SA, Cassady KR, Reading BJ, Noga EJ"	A Diverse Family of Host-Defense Peptides (Piscidins) Exhibit Specialized Anti-Bacterial and Anti-Protozoal Activities in Fishes.
DRAMP18203	SYVGDCGSNGGSCVSSYCPYGNRLNYFCPLGRTCCRRSY	39	"Panusin (beta defensins; crustaceans, arthropods, invertebrates, animals)"	A0A0S2XGP2(Precursor)	Belongs to the beta-defensin family	Not found	"the Caribbean spiny lobster, Panulirus genus"	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"		Not found	Not found	None	"Function: Active against E. coli, K. pneumonia, S. aureus, B. subtilisspizizenii, and C. albicans."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipid-binding	27616720	Dev Comp Immunol. pii: S0145-305X(16)30274-9(2016)	"Montero-Alejo V, Corzo G, Porro-Suard"	Panusin represents a new family of beta-defensin-like peptides in invertebrates.
DRAMP18120	PPTQNPSMAPPTQNPYGQPMTPPTQNPYGQPMAPP	35	BnPRP1 (Plant defensin)	No entry found		BnPRP1	Brassica napus	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	"BnPRP1 has 40.5% identity with a known proline-rich antimicrobial peptide SP-B from the pig. BnPRP1 isolated from B. napus was the first PR-AMP member that was characterized in plants, and its homology sequences were found in some other Brassicaceae plants by the genome sequences analysis. "	"Gram-positive: M. luteus (MIC= 16.9 ¡À 2.7 uM );##Gram-negative: E. coli (MIC= 8.4 ¡À 1.4 uM);## Fungi:Sclerotinia sclerotiorum, Mucor sp., Magnaporthe oryzae and Botrytis cinerea"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	26383098	PLoS One.?2015 Sep 18;10(9):e0137414.	"Cao H, Ke T, Liu R, et al."	Identification of a Novel Proline-Rich Antimicrobial Peptide from Brassica napus.
DRAMP18140	VARGWKRKCPLFGKGG	16	VG16KRKP	No entry found			Synthetic construct	"Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-"	Synthetic		The solution-NMR structure of VG16KRKP in lipopolysaccharide features a folded conformation with a centrally located turn-type structure stabilized by aromatic-aromatic packing interactions with extended N- and C-termini.	"2MXG,2MXH resolved by NMR"	VG16KRKP is capable of inhibiting bacterial disease progression in plants.	"Gram-negative: E. coli (MIC=8 uM), X. campestris  (MIC=10 uM), X. oryzae  (MIC=15 uM);##Gram-positive: B. subtilis (MIC=50 uM);##Fungi: Candida albicans  (MIC=2 uM), Cryptococcus grubii  (MIC=5 uM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	cell membrane	26144972	Sci Rep. 2015 Jul 6;5:11951.	"Datta A, Ghosh A, Airoldi C, etal."	"Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control"
DRAMP18194	GGLKKLGKKLEGAGKRVFKASEKALPVVVGIKAIGK	36	AAEL000598-PA	Q17NR1	Not found	CECD	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		alpha helical (N-terminal)	"The structure of Aedesin is depicted as a helix-bent-helix structure with good RMSD statistics for the N-terminal helix (helix 1) and for the C-terminal helix (helix 2) taken separately.The helical wheel diagram of Aedesin shows the amphipathic character of the first and second aloha helices, as well as the opposite localization of their hydrophobic and positively charged residues, respectively."	2MMM resolved by NMR.	"The anti-bacterial activity of Aedesin was found to be salt-resistant, indicating that it is active under physiological conditions encountered in body fluids characterized by ionic salt concentrations."	"Gram-negative (including drug-resistent): E. coli (MIC 2-4 ug/mL), P. aeruginosa (MIC 1-4 ug/mL), A. baumannii (MIC 1-2 ug/mL), K. pneunomiae (MIC 1-2 ug/mL).##No antibacterial effects of the peptide were observed against different isolates of Gram-positive S. aureus, E. faecalis and E. faecium strains showing MIC values over 32. (Pubmed:25162372)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17510324##25162372	Science 316:1718-1723(2007).##PLoS ONE 9:e105441-e105441(2014).	"Nene V., Wortman J.R., Lawson D., et al.##Godreuil S., Leban N., Padilla A., et al."	"Genome sequence of Aedes aegypti, a major arbovirus vector.##Aedesin: structure and antimicrobial activity against multidrugresistant bacterial strains."
DRAMP03635	GRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQA	48	"Human lactoferricin (LfcinH; one chain of Lactotransferrin; Human, mammals, animals)"	"P02788, B7Z4X2, E7EQH5, O00756, Q16780, Q16785, Q16786, Q16789, Q8IU92"	Belongs to the transferrin family	LTF	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Alpha helix	LfcinH shows a helical content from Gln14 to Lys29 in the membrane mimetic solvent but a nonexistent beta-sheet character in either the N- or C-terminal regions of the peptide. The LfcinH structure determined in aqueous solution displays a nascent helix in the form of a coiled conformation in the region from Gln14 to Lys29.	"1Z6V, 1Z6W resolved by NMR."	"Function: Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.
Tissue specificity: High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine."	Gram-negative bacterium: Escherichia coli serotype O111.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15155221##16048952	Antimicrob Agents Chemother. 2004 Jun;48(6):2190-2198.##Antimicrob Agents Chemother. 2005 Aug;49(8):3387-3395.	"Chapple DS, Hussain R, Joannou CL, Hancock RE, Odell E, Evans RW, Siligardi G.##Hunter HN, Demcoe AR, Jenssen H, Gutteberg TJ, Vogel HJ."	Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide.##Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent.
DRAMP03636	FFSASCVPGADKGQFPNLCRLCAGTGENKCA	31	"Kaliocin-1 (one chain of Lactotransferrin; Human, mammals, animals)"	"P02788, B7Z4X2, E7EQH5, O00756, Q16780, Q16785, Q16786, Q16789, Q8IU92"	Belongs to the transferrin family	LTF	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes without causing extensive damage to the outer and inner bacterial membranes.
Tissue specificity: High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine."	Gram-negative bacterium: Escherichia coli serotype O111.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12693969	Biochemistry (Mosc). 2003 Feb;68(2):217-227.	"Viejo-D¨ªaz M, Andr¨¦s MT, P¨¦rez-Gil J, S¨¢nchez M, Fierro JF."	Potassium efflux induced by a new lactoferrin-derived peptide mimicking the effect of native human lactoferrin on the bacterial cytoplasmic membrane.
DRAMP03639	GLSQGVEPDIGQTYFEESRINQD	23	Astexin-1 (lasso peptide)	No entry found	Not found	Not found	Asticcacaulis excentricus CB 48 (Gram-negative bacteria)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Beta strand (2 strands; 3 residues)	The solution structure of astexin-1 was determined and found to have a nine-membered macrolactam ring followed by an 8-aa loop and a 6-aa tail. The extended length of the loop and tail regions allow for hydrogen-bonding interactions between the backbone and polar side chains of these regions of the peptide.	2LTI resolved by NMR.	"Function: Astexin-1 has weak antimicrobial activity against Caulobacter crescentus. No growth inhibition is observed
for any other strains of bacteria tested, and the growth inhibition of C. crescentus is quite modest."	Gram-negative bacterium: Caulobacter crescentus CB15.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22949633	Proc Natl Acad Sci U S A. 2012 Sep 4. 	"Maksimov MO, Pelczer I, Link AJ."	Precursor-centric genome-mining approach for lasso peptide discovery.
DRAMP03641	DFGCGQGMIFMCQRRCMRLYPGSTGFCRGFRCMCDTHIPLRPPFMVG	47	"Longicornsin (defensin-like; Arthropods, invertebrates, animals)"	B2MW54	Not found	sGDLP	Haemaphysalis longicornis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has antibacterial activity.	"Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Helicobacter pylori.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20027626	Protein Sci. 2010 Mar;19(3):392-327.	"Lu X, Che Q, Lv Y, Wang M, Lu Z, Feng F, Liu J, Yu H."	"A novel defensin-like peptide from salivary glands of the hard tick, Haemaphysalis longicorn."
DRAMP03644	RVKRVWPLVIRTVIAGYNLYRAIKKK	26	"Cathelicidin-1 (CATH-1; Fowlicidin-1; Birds, animals)"	"Q6QLQ5, Q2IAM1"	Not found	CATHL1	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytolytic"	Protein level	Alpha helix (2 helices; 13 residues)	"Fowlicidin-1 mainly adopts an alpha-helical conformation with a slight kink induced by glycine close to the center, in addition to a short flexible unstructured region near the N terminus. The short C-terminal helical segment after the kink, consisting of a stretch of eight amino acids (residues 16-23), may be required for the peptide to interact with LPS and lipid membranes and to permeabilize both prokaryotic and eukaryotic cells."	2AMN resolved by NMR.	"Function: Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.
Animal model (mouse): It increased mice survival by 50% from a lethal dose of S. aureus (MRSA). This truncated peptide also reduced TNF-alpha and NO production in macrophage by 77% and 96%, respectively."	"[Ref.16326712]Gram-negative bacteria:?[No NaCl]Escherichia coli 25922 (MIC=1.59 ?M), Escherichia coli O157:H7 700728 (MIC=0.80 ?M), Salmonella typhimurium 14028 (MIC=0.80 ?M), Salmonella typhimurium DT104 700408 (MIC=0.40 ?M), Klebsiella pneumoniae 13883 (MIC=0.40 ?M), Pseudomonas aeruginosa 27853 (MIC=3.18 ?M);##[100mM NaCl]Escherichia coli 25922 (MIC=1.59 ?M), Escherichia coli O157:H7 700728 (MIC=0.80 ?M), Salmonella typhimurium 14028 (MIC=1.59 ?M), Salmonella typhimurium DT104 700408 (MIC=1.59 ?M), Klebsiella pneumoniae 13883 (MIC=0.80 ?M), Pseudomonas aeruginosa 27853 (MIC=3.18 ?M);##Gram-positive bacteria:?Listeria monocytogenes 19115 (MIC=0.80 ?M), Staphylococcus aureus 25923 (MIC=0.80 ?M), Staphylococcus aureus (MRSA) BAA-39 (MIC=0.40 ?M), Staphylococcus aureus (MRSA) 43300 (MIC=0.40 ?M);##[100mM NaCl]Listeria monocytogenes 19115 (MIC=1.59 ?M), Staphylococcus aureus 25923 (MIC=0.80 ?M), Staphylococcus aureus (MRSA) BAA-39 (MIC=0.80 ?M), Staphylococcus aureus (MRSA) 43300 (MIC=0.40 ?M)"	[Ref.16326712]80% hemolytic activity at 10 ¦ÌM against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	16326712##16817888	 Biol Chem. 2006 Feb 3;281(5):2858-2867.##FEBS J. 2006 Jun;273(12):2581-2593. 	"Xiao Y, Cai Y, Bommineni YR, Fernando SC, Prakash O, Gilliland SE, Zhang G.##Xiao Y, Dai H, Bommineni YR, Soulages JL, Gong YX, Prakash O, Zhang G."	"Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity.##Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken."
DRAMP03648	GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIWG	40	"Gallinacin-1 (Gal-1; Beta-defensin 1; Birds, animals)"	"P46156, Q09MK1, Q6B9W7, Q6GXJ4"	Belongs to the beta-defensin family	GAL1	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge 	Not found	None	"Tissue specificity: Strong expression in the bone marrow, lung, testis. Moderate expression in the bursa and intestine. Low expression in the cloaca, gall bladder, brain and pancreas. Expressed in the vagina, ovarian stroma and the theca and granulosa layers of the ovarian follicle.
Developmental stage: Detected in the theca layer of the ovarian follicle in the white follicle (WF) stage, but decreases throughout the F1, F3, F5, and postovulatory follicle stages. Detected in the granulosa layer of the ovarian follicle in the white follicle (WF) stage, F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.
Induction: Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Repressed in the granulosa layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in cultured vaginal cells is increased by LPS and S.enteritidis. Expression in the kidney and liver is not affected by intravenous injection of LPS.
PTM: Contains three disulfide bonds 6-34; 13-28; 18-35."	Gram-negative bacterium: Escherichia coli ML-35;##Gram-positive bacterium: Listeria monocytogenes.##Yeast: Candida albicans.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8150085##16394622##17244739	FEBS Lett. 1994 Apr 11;342(3):281-285.##J Reprod Dev. 2006 Apr;52(2):211-218.##Reproduction. 2007 Jan;133(1):127-133.	"Harwig SS, Swiderek KM, Kokryakov VN, Tan L, Lee TD, Panyutich EA, Aleshina GM, Shamova OV, Lehrer RI.##Yoshimura Y, Ohashi H, Subedi K, Nishibori M, Isobe N.##Subedi K, Isobe N, Nishibori M, Yoshimura Y."	"Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes.##Effects of age, egg-laying activity, and Salmonella-inoculation on the expressions of gallinacin mRNA in the vagina of the hen oviduct.##Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus)."
DRAMP03649	GRKSDCFRKNGFCAFLKCPYLTLISGKCSRFHLCCKRIW	39	"Gallinacin-1 alpha (Gal-1 alpha; Antimicrobial peptide CHP2; Birds, animals)"	"P46157, P80390, Q09MR8, Q9DG59"	Belongs to the beta-defensin family	Not found	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	PTM: Contains three disulfide bonds 6-34; 13-28; 18-35.	"Gram-negative bacterium: Escherichia coli ML-35;##Gram-positive bacteria: Staphylococcus aureus, Listeria monocytogenes.##Yeast: Candida albicans."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7964174##8150085	J Leukoc Biol. 1994 Nov;56(5):661-665.##FEBS Lett. 1994 Apr 11;342(3):281-285.	"Evans EW, Beach GG, Wunderlich J, Harmon BG.##Harwig SS, Swiderek KM, Kokryakov VN, Tan L, Lee TD, Panyutich EA, Aleshina GM, Shamova OV, Lehrer RI."	Isolation of antimicrobial peptides from avian heterophils.##Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes.
DRAMP03650	LFCKGGSCHFGGCPSHLIKVGSCFGFRSCCKWPWNA	36	"Gallinacin-2 (Gal-2; Beta-defensin 2; Birds, animals)"	"P46158, Q09MT0, Q0PWH3, Q6B9W8, Q6GXJ3"	Belongs to the beta-defensin family	GAL2	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Beta strand (3 strands; 11 residues)	The three-dimensional NMR structure of chicken AvBD2 defensin displays the structural three-stranded antiparallel ¦Â-sheet characteristic of ¦Â-defensins. The surface of the molecule does not display any amphipathic character.	"2LG5, 2LG6 resolved by NMR."	"Tissue specificity: Expressed in circulating heterophil granulocytes and bone marrow (at protein level). Strong expression in the bone marrow, lung and testis. Moderate expression in the bursa and intestine. Low expression in the cloaca, gall bladder, brain, pancreas, trachea, air sacs and spleen. Expressed in the vagina, ovarian stroma and the theca layer of the ovarian follicle, but not in the granulosa layer of the ovarian follicle.
Developmental stage: Detected in the theca layer of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.
Induction: Not induced in the ovarian follicle by intravenous injection of LPS. Expression in cultured vaginal cells is increased by LPS and S.enteritidis.
PTM: Contains three disulfide bonds 3-29, 8-23, 13-30."	"Gram-negative bacteria: Escherichia coli ML-35, Salmonella enteritidis;##Gram-positive bacteria: Bacillus cereus, Listeria monocytogenes."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	8150085##19151352##15148642##17244739##16394622##22205	FEBS Lett. 1994 Apr 11;342(3):281-285.##Poult Sci. 2009 Feb;88(2):372-379.##Immunogenetics. 2004 Jun;56(3):170-177.##Reproduction. 2007 Jan;133(1):127-133.##J Reprod Dev. 2006 Apr;52(2):211-218.##J Biol Chem. 	"Harwig SS, Swiderek KM, Kokryakov VN, Tan L, Lee TD, Panyutich EA, Aleshina GM, Shamova OV, Lehrer RI.##Kannan L, Rath NC, Liyanage R, Lay JO Jr.##Lynn DJ, Higgs R, Gaines S, Tierney J, James T, Lloyd AT, Fares MA, Mulcahy G, O'Farrelly C.##Subedi K, Isobe N, Nishibori M, Yoshimura Y.##Yoshimura Y, Ohashi H, Subedi K, Nishibori M, Isobe N.##Derache C, Meudal H, Aucagne V, Mark KJ, Cad¨¨ne M, Delmas AF, Lalmanach AC, Landon C."	"Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes.##Direct screening identifies mature beta-defensin 2 in avian heterophils.##Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken.##Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus).##Effects of age, egg-laying activity, and Salmonella-i"
DRAMP03652	RYHMQCGYRGTFCTPGKCPHGNAYLGLCRPKYSCCRWL	38	"Gallinacin-4 (Gal-4; Beta-defensin 4; Birds, animals)"	"Q6GXJ1, Q0PXU4, Q6QLR0"	Belongs to the beta-defensin family	GAL4	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Bridge	Not found	None	"Tissue specificity: Strong expression in the bone marrow and testis. Widely expressed. Weak expression in the ovarian stroma, but not expressed in the ovarian follicles. PTM: Contains three disulfide bonds 6-34; 13-28; 18-35."	"Gram-negative bacteria: Salmonella typhimurium, Salmonella entiriditis."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17346671##15310403##15148642##17244739	Biochem Biophys Res Commun. 2007 Apr 27;356(1):169-174.##BMC Genomics. 2004 Aug 13;5(1):56.##Immunogenetics. 2004 Jun;56(3):170-177.##Reproduction. 2007 Jan;133(1):127-133.	"Milona P, Townes CL, Bevan RM, Hall J.##Xiao Y, Hughes AL, Ando J, Matsuda Y, Cheng JF, Skinner-Noble D, Zhang G.##Lynn DJ, Higgs R, Gaines S, Tierney J, James T, Lloyd AT, Fares MA, Mulcahy G, O'Farrelly C.##Subedi K, Isobe N, Nishibori M, Yoshimura Y."	"The chicken host peptides, gallinacins 4, 7, and 9 have antimicrobial activity against Salmonella serovars.##A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.##Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken.##Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response "
DRAMP03653	GLPQDCERRGGFCSHKSCPPGIGRIGLCSKEDFCCRSRWYS	41	"Gallinacin-5 (Gal-5; Beta-defensin 5; Birds, animals)"	"Q6IV26, Q09MS7, Q0PWH0, Q6QLQ8"	Belongs to the beta-defensin family	GAL5	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Not found	Not found	None	"Tissue specificity: Strong expression in the tongue and bone marrow. Low expression in the esophagus, trachea, lung, brain and ovary. Expressed in the ovarian stroma, but not in the ovarian follicles. PTM: contains three disulfide bonds 6-34; 13-28; 18-35."	"Gram-negative bacteria: Salmonella typhimurium, Salmonella entiriditis."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17346671##15310403##15148642##17244739	Biochem Biophys Res Commun. 2007 Apr 27;356(1):169-174.##BMC Genomics. 2004 Aug 13;5(1):56.##Immunogenetics. 2004 Jun;56(3):170-177.##Reproduction. 2007 Jan;133(1):127-133.	"Milona P, Townes CL, Bevan RM, Hall J.##Xiao Y, Hughes AL, Ando J, Matsuda Y, Cheng JF, Skinner-Noble D, Zhang G.##Lynn DJ, Higgs R, Gaines S, Tierney J, James T, Lloyd AT, Fares MA, Mulcahy G, O'Farrelly C.##Subedi K, Isobe N, Nishibori M, Yoshimura Y."	"The chicken host peptides, gallinacins 4, 7, and 9 have antimicrobial activity against Salmonella serovars.##A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.##Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken.##Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response "
DRAMP03654	SPIHACRYQRGVCIPGPCRWPYYRVGSCGSGLKSCCVRNRWA	42	"Gallinacin-6 (Gal 6; Beta-defensin 6; Birds, animals)"	Q6QLR3	Belongs to the beta-defensin family	GAL6	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Bridge	Not found	None	"Tissue specificity: Expressed in bone marrow, testis, ovary, lung and trachea. Expressed in the ovarian stroma, but not in the ovarian follicles. PTM: Contains three disulfide bonds 6-35; 13-28; 18-36."	"Gram-negative bacteria: Salmonella typhimurium, Salmonella entiriditis."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17346671##15310403##15148642##17244739	Biochem Biophys Res Commun. 2007 Apr 27;356(1):169-174.##BMC Genomics. 2004 Aug 13;5(1):56.##Immunogenetics. 2004 Jun;56(3):170-177.##Reproduction. 2007 Jan;133(1):127-133.	"Milona P, Townes CL, Bevan RM, Hall J.##Xiao Y, Hughes AL, Ando J, Matsuda Y, Cheng JF, Skinner-Noble D, Zhang G.##Lynn DJ, Higgs R, Gaines S, Tierney J, James T, Lloyd AT, Fares MA, Mulcahy G, O'Farrelly C.##Subedi K, Isobe N, Nishibori M, Yoshimura Y."	"The chicken host peptides, gallinacins 4, 7, and 9 have antimicrobial activity against Salmonella serovars.##A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.##Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken.##Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response "
DRAMP03655	RPIDTCRLRNGICFPGICRRPYYWIGTCNNGIGSCCARGWRS	42	"Gallinacin-7 (Gal 7; Beta-defensin 7; Birds, animals)"	"Q6QLR2, Q09MR1, Q09MV1"	Belongs to the beta-defensin family	GAL7	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram-"	Transcript level	Bridge	Not found	None	"Tissue specificity: Strong expression in the bone marrow and testis. Expressed in the ovarian stroma and the theca layer of the ovarian follicles. Not expressed in the granulosa layer of the ovarian follicles.
Developmental stage: Detected in the theca and granulosa layers of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages. Induction: Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in the kidney and liver is not affected by intravenous injection of LPS.
PTM: Contains three disulfide bonds 6-35; 13-28; 18-36."	Gram-negative bacterium: Salmonella enteriditis.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15148642##15310403##17244739	Immunogenetics. 2004 Jun;56(3):170-177.##BMC Genomics. 2004 Aug 13;5(1):56.##Reproduction. 2007 Jan;133(1):127-133.	"nn DJ, Higgs R, Gaines S, Tierney J, James T, Lloyd AT, Fares MA, Mulcahy G, O'Farrelly C.##Xiao Y, Hughes AL, Ando J, Matsuda Y, Cheng JF, Skinner-Noble D, Zhang G.##Subedi K, Isobe N, Nishibori M, Yoshimura Y."	"Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken.##A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.##Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus)."
DRAMP03661	FSDSQLCRNNHGHCRRLCFHMESWAGSCMNGRLRCCRFSTKQPFSNPKHSVLHTAEQDPSPSLGGT	66	"Gallinacin-13 (Gal-13; Beta-defensin 13; Birds, animals)"	"Q6IV18, Q66VU2"	Belongs to the beta-defensin family	GAL13	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Tissue specificity: Expressed in the liver, gall bladder, kidney, small intestine, spleen, testis, ovary and male and female reproductive tracts. Not detected in the ovarian stroma and the theca and granulosa layers of the ovarian follicle. PTM: Contains three disulfide bonds 7-35; 14-28; 18-36."	"Gram-negative bacteria: Escherichia coli, Salmonella typhimurium;##Gram-positive bacteria: Listeria monocytogenes, Streptococcus pyogenes."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17244739##15310403##15744537	Reproduction. 2007 Jan;133(1):127-133.##BMC Genomics. 2004 Aug 13;5(1):56.##Immunogenetics. 2005 Apr;57(1-2):90-98.	"Subedi K, Isobe N, Nishibori M, Yoshimura Y.##Xiao Y, Hughes AL, Ando J, Matsuda Y, Cheng JF, Skinner-Noble D, Zhang G.##Higgs R, Lynn DJ, Gaines S, McMahon J, Tierney J, James T, Lloyd AT, Mulcahy G, O'Farrelly C."	"Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus).##A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.##The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens."
DRAMP03663	MTPFWRGVSLRPVGASCRDNSECITMLCRKNRCFLRTASE	40	"cLEAP-2 (Chicken LEAP-2; Birds, animals)"	No entry found	Not found	Not found	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-negative bacteria: S. enterica serovar Typhimurium strain SL1344, mutant S. enterica serovar Typhimurium strain phoP."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	cell membrane	15557621	Infect Immun. 2004 Dec;72(12):6987-6893.	"wnes CL, Michailidis G, Nile CJ, Hall J."	Induction of cationic chicken liver-expressed antimicrobial peptide 2 in response to Salmonella enterica infection.
DRAMP03664	ADNKNPLEECFRETNYEEFLEIAR	24	"L-amino-acid oxidase (LAAO, LAO, TM-LAO; reptilia, animals)"	P0C2D6	Not found	Not found	Trimeresurus mucrosquamatus (Taiwan habu) (Protobothrops mucrosquamatus)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis, and antiparasitic activities By similarity. This protein has antibacterial activity abd cytotoxic activity, as well as an ability to induce platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions.
Tissue specificity: Expressed by the venom gland. PTM: Contains one disulfide bond."	"Gram-negative bacterium: E. coli;##S. aureus, B. dysenteriae."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12621545	Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Mar;35(3):219-224.	"Wei JF, Wei Q, Lu QM, Tai H, Jin Y, Wang WY, Xiong YL."	"Purification, characterization and biological activity of an L-amino acid oxidase from Trimeresurus mucrosquamatus venom."
DRAMP03674	DTHISEKIIDCNDIG	15	Cystatin-1 (Cystatin-I)	P84911	Belongs to the caerin subfamily	Not found	Capra hircus (Goat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Inhibits papain, ficin and bromelain with an IC50 of 0.09 ?M, 0.115 ?M and 0.113 ?M respectively. Has antibacterial activity against Gram-positive bacteria and against the Gram-negative bacteria. Reduced antibacterial activity against Gram-positive bacterium B.subtilis. No antibacterial activity against the Gram-negative bacterium P.fluorescens.
Miscellaneous: Stable in the pH range 5.0-9.0 at 37 degrees Celsius. Stable when incubated in the temperature range 25-75 degrees Celsius and pH 7.5.
Sequence uncertainty: K or Y at position 7."	"[Swiss_Prot Entry P84911]has antibacterial activity against Gram-positive bacteria S.aureus and S.hemolyticus, and against the Gram-negative bacterium E.coli. Reduced antibacterial activity against Gram-positive bacterium B.subtilis. No antibacterial activity against the Gram-negative bacterium P.fluorescens"	[Swiss_Prot Entry P84911]Not found	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16257555	Comp Biochem Physiol B Biochem Mol Biol. 2005 Dec;142(4):361-368. 	"Sadaf Z, Shahid PB, Bilqees B."	"Isolation, characterization and kinetics of goat cystatins."
DRAMP03680	RFRLPFRRPPIRIHPPPFYPPFRRFL	26	"Cathelicidin-3.4 (Bactenecin-3.4, Bac3.4; ChBac3.4; ruminant, animals)"	P85170	Belongs to the cathelicidin family	Not found	Capra hircus (Goat)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has low hemolytic activity towards human red blood cells. 	"[Swiss_Prot Entry P85170]Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa;##Gram-positive bacteria: Staphylococcus aureus, Listeria monocytogenes"	[Swiss_Prot Entry P85170]Low hemolytic activity against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (MAY-2007) to UniProtKB.	"Shamova O, Orlov D, Stegemann C, Lehrer RI, Brogden KA, Kolodkin N, Hoffmann R, Kokryakov VN."	Unknown
DRAMP03692	ACQFWSCNSSCISRGYRQGYCWGIQYKYCQCQ	32	"Defensin-1 (Cll-dlp; Arthropods, animals)"	"Q6GU94, P83738"	Belongs to the invertebrate defensin family	Not found	Centruroides limpidus limpidus (Mexican scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial protein involved in the immune response to septic injury. When combined with 14.026 kDa and 14.059 kDa hemolymph antimicrobial peptides, it has a strong cooperative activity against bacteria. No detectable antibacterial activity when present alone. Has no hemolytic activity against human erythrocytes.
Induction: By septic injury.
PTM: Contains three disulfide bonds 2-21; 7-29; 11-31."	"[Ref.15197474]Gram-positive bacteria: Bacillus subtilis (MIC>50 ?g/ml), Staphylococcus aureus ATCC 25923 (MIC>50 ?g/ml);##Gram-negative bacteria: Escherichia coli DH5a (MIC>50 ?g/ml), Klebsiella pneumoniae ATCC 13883 (MIC>50 ?g/ml).##NOTE: Liquid growth inhibition assay."	[Swiss_Prot Entry Q6GU94]Non-hemolytic activity against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15197474	Cell Mol Life Sci. 2004 Jun;61(12):1507-1519.	"Rodr¨ªguez de la Vega RC, Garc¨ªa BI, D'Ambrosio C, Diego-Garc¨ªa E, Scaloni A, Possani LD."	Antimicrobial peptide induction in the haemolymph of the Mexican scorpion Centruroides limpidus limpidus in response to septic injury.
DRAMP03736	GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNFVAEKIGATPS	44	"Opistoporin-2 (OP2; Non-disulfide-bridged peptide 3.6, NDBP-3.6; Arthropods, animals)"	P83314	Belongs to the antimicrobial peptide scorpion family	Not found	Opistophthalmus carinatus (African yellow leg scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	"Function: At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has weak hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity. (By similarity)
Tissue specificity: Expressed by the venom gland."	[Swiss_Prot Entry P83314]strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity.	[Swiss_Prot Entry P83314]Weak hemolytic activity against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	12354111	Eur J Biochem. 2002 Oct;269(19):4799-4810.	"Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, Thevissen K, Tytgat J, Van Eldere J, Van Der Walt J, Verdonck F."	"Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa."
DRAMP03737	GKVWDWIKKTAKDVLNSDVAKQLKNKALNAAKNFVAEKIGATPS	44	"Opistoporin-4 (Non-disulfide-bridged peptides 3.7, NDBP-3.7; Arthropods, animals)"	Q5VJS9	Belongs to the antimicrobial peptide scorpion family	Not found	Opistophthalmus carinatus (African yellow leg scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has weak hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity. (By similarity)
Tissue specificity: Expressed by the venom gland."	[Swiss_Prot Entry Q5VJS9]strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity.	[Swiss_Prot Entry Q5VJS9]Weak hemolytic activity against human erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	PubMed ID is not available	Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases	"Zhu S, Tytgat J."	Precursor organization and gene structure of scorpion venom antimicrobial peptides.
DRAMP03739	SIVPIRCRSNRDCRRFCGFRGGRCTYARQCLCGY	34	"Buthinin (Sahara scorpion; Arthropods, animals)"	"P56685, P81617"	Not found	Not found	Androctonus australis (Sahara scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	Function: Active against both Gram-positive and Gram-negative bacteria.	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Micrococcus luteus.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	Has three disulfide bonds	L	No cytotoxicity information found	Not found	8939880	J Biol Chem. 1996 Nov 22;271(47):29537-29544.	"Ehret-Sabatier L, Loew D, Goyffon M, Fehlbaum P, Hoffmann JA, van Dorsselaer A, Bulet P."	Characterization of novel cysteine-rich antimicrobial peptides from scorpion blood.
DRAMP03740	GFGCPFNQGACHRHCRSIRRRGGYCAGLFKQTCTCYR	37	"Androctonus defensin (4 kDa defensin; Arthropods, animals)"	"P56686, P81618"	Belongs to the invertebrate defensin family (Type 2 subfamily)	Not found	Androctonus australis (Sahara scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Bridge	Not found	None	Function: Active against both Gram-positive and Gram-negative bacteria.	Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Micrococcus luteus.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8939880	J Biol Chem. 1996 Nov 22;271(47):29537-29544.	"Ehret-Sabatier L, Loew D, Goyffon M, Fehlbaum P, Hoffmann JA, van Dorsselaer A, Bulet P."	Characterization of novel cysteine-rich antimicrobial peptides from scorpion blood.
DRAMP03741	IFGSLFSLGSKLLPSVFKLFSRKKQ	25	"Ponericin-W-like 32.1 (Arthropods, animals)"	P0CI91	Belongs to the ponericin-W family	Not found	Lychas mucronatus (Chinese swimming scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Insecticidal"	Transcript level	Not found	Not found	None	"Function: Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities (By similarity).
Tissue specificity: Expressed by the venom gland."	[Swiss_Prot Entry P0CI91]Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae	[Swiss_Prot Entry P0CI91]has hemolytic activities	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20663230	BMC Genomics. 2010 Jul 28;11:452.	"Ruiming Z, Yibao M, Yawen H, Zhiyong D, Yingliang W, Zhijian C, Wenxin L."	Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components.
DRAMP03742	IFGSLFSLGSKLLPTVFKLFSRKKQ	25	"Ponericin-W-like 32.2 (Arthropods, animals)"	P0CI92	Belongs to the ponericin-W family	Not found	Lychas mucronatus (Chinese swimming scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Insecticidal"	Transcript level	Not found	Not found	None	"Function: Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities (By similarity).
Tissue specificity: Expressed by the venom gland."	[Swiss_Prot Entry P0CI92]Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae	[Swiss_Prot Entry P0CI92]has hemolytic activities	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20663230	BMC Genomics. 2010 Jul 28;11:452.	"Ruiming Z, Yibao M, Yawen H, Zhiyong D, Yingliang W, Zhijian C, Wenxin L."	Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components.
DRAMP03755	QFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS	37	"Potassium channel toxin alpha-KTx 1.1 (ChTX-Lq1; charybdotoxin; Arthropods, animals)"	P13487	Not found	Not found	Leiurus quinquestriatus hebraeus (Yellow scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral"	Protein level	Combine helix and strand structure	These structures show that charybdotoxin is composed of a beta-sheet linked to an alpha-helix by two disulphide bridges and to an extended fragment by the third disulphide bridge. 	"1BAH, 2CRD resolved by NMR."	"Function: Potent selective inhibitor of high conductance (maxi-K), different medium and small conductance calcium-activated potassium channels (KCa/KCNM), as well as a voltage-dependent potassium channel (Kv1.3/KCNA3). It appears to block channel activity by a simple bimolecular inhibition process.
Tissue specificity: Expressed by the venom gland.
Domain: Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).
PTM: Contains three disulfide bonds."	"Gram-positive bacteria: B.subtilis, S.aureus;##Gram-negative bacterium: E.coli.##Yeast: Candida albicans. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15118082##1705886##9092804##1380828	Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-7368.##Eur J Biochem. 1991 Feb 26;196(1):19-28.##Biochemistry. 1997 Apr 1;36(13):3760-3766.##Biochemistry. 1992 Sep 1;31(34):7756-7764.	"Yount NY, Yeaman MR.##Bontems F, Roumestand C, Boyot P, Gilquin B, Doljansky Y, Menez A, Toma F.##Song J, Gilquin B, Jamin N, Drakopoulou E, Guenneugues M, Dauplais M, Vita C, M¨¦nez A.##Bontems F, Gilquin B, Roumestand C, M¨¦nez A, Toma F."	Multidimensional signatures in antimicrobial peptides.##Three-dimensional structure of natural charybdotoxin in aqueous solution by 1H-NMR. Charybdotoxin possesses a structural motif found in other scorpion toxins.##NMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packing.##Analysis of side-chain organization on a refined model of charybdotoxin: structural and functional i
DRAMP03766	GWINEEKIQKKIDEKIGNNILGGMAKAVVHKLAKGEFQCVANIDTMGNCETHCQKTSGEKGFCHGTKCKCGKPLSY	76	"Heteroscorpine-1 (HS-1; defensins; Arthropods, animals)"	P0C2F4	Belongs to the long chain scorpion toxin family (Class 3 subfamily)	Not found	Heterometrus laoticus (Thai giant scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has antibacterial activity.
Tissue specificity: Expressed by the venom gland.
PTM: Contains three disulfide bonds (By similarity).
Toxic dose: PD50 is 80 ul to crickets (Gryllus sp)."	"Gram-positive bacterium: Bacillus subtilis (5.2 mm);##Gram-negative bacteria: Klebsiella pneumoniae (10.57 mm), Pseudomonas aeruginosa (6.4 mm).##NOTE: Diameter of clear zone from disc diffusion assay. Total protein is 6.25 ?mole."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17056081	Toxicon. 2007 Jan;49(1):19-29.	"Uawonggul N, Thammasirirak S, Chaveerach A, Arkaravichien T, Bunyatratchata W, Ruangjirachuporn W, Jearranaiprepame P, Nakamura T, Matsuda M, Kobayashi M, Hattori S, Daduang S."	Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom.
DRAMP03785	QWGYGGYGRGYGGYGGYGRGMYGGYGRGMYGGYGRGMYGGYGRGMYGGWGK	51	"Neuropeptide-like protein 29 (NLP-29; nematodes, animals)"	O44664	Not found	nlp-29	Caenorhabditis elegans	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Antimicrobial peptides that have antibacterial and antifungal activity.
Tissue specificity: Weakly or not expressed in absence of infection. Upon infection by D. coniospora, it is expressed in hypoderm. Also expressed in perivulval cells when D. coniospora spores adhere to this region.
Induction: Upon D. coniospora and S. marcescens infection.
PTM: C-terminal amidation."	Gram-negative bacterium: S. marcescens.##Fungi: D. coniospora.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11717458##15048112	Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14000-14005.##Nat Immunol. 2004 May;5(5):488-494.	"Nathoo AN, Moeller RA, Westlund BA, Hart AC.##Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ."	"Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species.##TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM."
DRAMP03787	NAQWGYGGYGRGYGGYGGYGRGYGGYGGYGRGYGGYGRGMYGGYGRPYGGYGWGK	55	"Neuropeptide-like protein 31 (NLP-31; nematodes, animals)"	O44662	Belongs to the YARP family	nlp-31	Caenorhabditis elegans	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	"Function: Antimicrobial peptide that has antifungal and weak antibacterial activity.
Tissue specificity: Expressed in hypoderm.
Developmental stage: Expressed in precomma stasge embryos.
Induction: Strongly up-regulated upon D. coniospora infection.
PTM: C-terminal amidation."	Gram-positive bacterium: Micrococcus luteus;##Gram-negative bacterium: E.coli.##Fungi: D.coniospora.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11717458##15048112	Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14000-5.##Nat Immunol. 2004 May;5(5):488-494.	"Nathoo AN, Moeller RA, Westlund BA, Hart AC.##Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ."	"Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species.##TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM."
DRAMP03790	DIDFSTCARMDVPILKKAAQGLCITSCSMQNCGTGSCKKRSGRPTCVCYRCANGGGDIPLGALIKRG	67	"ABF-2 (nematodes, animals)"	G5EC68	Not found	abf-2	Caenorhabditis elegans	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Predicted	Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: Bacillus subtilis IFO3134 (BC50=0.09 ?M), Kocuria varians MAFF118076 (BC50=0.008 ?M), Staphylococcus aureus ATCC6538P (BC50=0.005 ?M);##Gram-negative bacteria: Agrobacterium tumefaciens MAFF1001 (BC50=0.05 ?M), Bdellovibrio bacteriovorus MAFF106101 (BC50=0.06 ?M), Klebsiella pneumoniae MAFF519002 (BC50=0.9 ?M), Escherichia coli JM109 (BC50>15 ?M).##Fungi: Candida krusei MAFF114085 (BC50=0.3 ?M), Debaryomyces hansenii MAFF113836 (BC50>15 ?M), Kluyveromyces thermotolerans MAFF113848 (BC50=0.3 ?M), Paeonia anomala MAFF113717 (BC50=0.08 ?M), Saccharomyces cerevisiae MAFF113011 (BC50=0.6 ?M), Torulaspora delbrueckiiMAFF113811 (BC50>15 ?M). "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11772394	Biochem J. 2002 Jan 15;361(Pt 2):221-230.	"Kato Y, Aizawa T, Hoshino H, Kawano K, Nitta K, Zhang H."	"abf-1 and abf-2, ASABF-type antimicrobial peptide genes in Caenorhabditis elegans."
DRAMP03798	MPCSCKKYCDPWEVIDGSCGLFNSKYICCREK	32	"Corticostatin-related peptide RK-1 (RK-1; lagomorphs, mammals, animals)"	P81655	Belongs to the alpha-defensin family	Not found	Oryctolagus cuniculus (Rabbit) 	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Beta strand(3 strands; 13 residues)	"RK-1 consists of 32 residues, including six cysteines arranged into three disulfide bonds. The three-dimensional solution structure, determined by NMR, consists of a triple-stranded antiparallel beta-sheet and a series of turns and is similar to the known structures of other alpha-defensins (Ref.3)."	1EWS resolved by NMR.	"Function: Has antimicrobial activity against Escherichia coli and activates Ca(2+) channels in vitro.
PTM: Contains three disulfide bonds 3-29; 5-19; 9-28."	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys3 and Cys29,Cys5 and Cys19,Cys9 and Cys28."	L	No cytotoxicity information found	Not found	8631871##11123900	J Biol Chem. 1996 May 3;271(18):10654-10659.##Biochemistry. 2000 Dec 26;39(51):15757-15764.	"Bateman A, MacLeod RJ, Lembessis P, Hu J, Esch F, Solomon S.##McManus AM, Dawson NF, Wade JD, Carrington LE, Winzor DJ, Craik DJ."	The isolation and characterization of a novel corticostatin/defensin-like peptide from the kidney.##Three-dimensional structure of RK-1: a novel alpha-defensin peptide.
DRAMP03799	KPYCSCKWRCGIGEEEKGICHKFPIVTYVCCRRP	34	"Rabbit kidney defensin RK-2 (alpha-defensins; lagomorphs, mammals, animals)"	No entry found	Belongs to the alpha-defensin family	Not found	Oryctolagus cuniculus (Rabbit)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Bridge 	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9663443	Peptides. 1998;19(5):793-799.	"Wu ER, Daniel R, Bateman A."	RK-2: a novel rabbit kidney defensin and its implications for renal host defense.
DRAMP03812	GFFALIPKIISSPLFKTLLSAVGSALSSSGGQE	33	Pardaxin P-4 (Pardaxin P1a; Pardaxin Pa4)	P81861	Belongs to the pardaxin family	Not found	Pardachirus marmoratus (Finless sole) (Achirus marmoratus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytotoxic"	Protein level	Alpha helix (2 helices; 15 residues)	"The peptide adopts a bend-helix-bend-helix motif with an angle between the two structure helices of 122 +/- 9 degrees, making this structure substantially different from the one previously determined in organic solvents."	"1XC0, 2KNS resolved by NMR."	"Function: Exhibits unusual shark repellent and surfactant properties. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Domain: Consists of a C-terminal hydrophilic region and a predominantly hydrophobic remainder.  Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria"	"[Ref.23598079] Gram-positive bacteria : Micrococcus luteus(MIC=100 mg/L), Staphylococcus aureus(MIC=50 mg/L), Streptococcus pneumoniae(MIC=100 mg/L), Streptococcus agalactiae(MIC=100 mg/L), Staphylococcus sp.(MIC=6.25 mg/L);##Gram-negative bacteria : Grouper Vibrio alginolyticus(MIC=50 mg/L), Vibrio harveyi(MIC=50 mg/L), Vibrio vulnificus(MIC=100 mg/L)"	"[Ref.23598079] 7% hemolysis at 12.5 mg/L , 10% hemolysis at 25 mg/L , 27% hemolysis at 50 mg/L , 55% hemolysis at 100 mg/L , 95% hemolysis at 200 mg/L , 90% hemolysis at 400 mg/L against sheep red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	12124282##19959835##15292173##23598079	Biophys J. 2002 Aug;83(2):1004-1013.##J Biol Chem. 2010 Feb 5;285(6):3883-3895.##J Biol Chem. 2004 Oct 29;279(44):45815-23.##Peptides.?2013 Jun;44:139-48.	"Hallock KJ, Lee DK, Omnaas J, Mosberg HI, Ramamoorthy A.##Bhunia A, Domadia PN, Torres J, Hallock KJ, Ramamoorthy A, Bhattacharjya S.##Porcelli F, Buck B, Lee DK, Hallock KJ, Ramamoorthy A, Veglia G.##Lin MC, Hui CF, Chen JY, Wu JL"	"Membrane composition determines pardaxin's mechanism of lipid bilayer disruption.##NMR structure of pardaxin, a pore-forming antimicrobial peptide, in lipopolysaccharide micelles: mechanism of outer membrane permeabilization.##Structure and orientation of pardaxin determined by NMR experiments in model membranes.##Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus."
DRAMP18190	FLSTIWNGIKSLL	13	"Pantinin-3 (Non-disulfide-bridged peptide 4.22, NDBP-4.22, Non-disulfide-bridged peptide 5.23, ND"	R4JJN6	 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short an	Not found	Pandinus imperator (Emperor scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Amphipathic peptide that possesses relatively strong activities against Gram-positive bacteria and a fungus, but has very weak antimicrobial activities against Gram-negative bacteria. Also exhibits hemolytic activities against human erythrocytes. Furthermore, this peptide potently inhibits the growth of vancomycin-resistant Enterococcus (VRE) S13, a pathogen that can cause a number of human infections.Forms an alpha-helical membrane channel in the prey."	"[Ref.23624072]Gram-positive bacteria: S.aureus (MIC=16 ¦ÌM), B.magaterium (MIC=6 ¦ÌM), M.luteus (MIC=8 ¦ÌM ), VRE (MIC=4 ¦ÌM), MRSA (MIC=12 ¦ÌM);##Gram-negative bacteria: E.coli (MIC=36 ¦ÌM), P.putida (MIC >87 ¦ÌM), K.oxytoca (MIC=87 ¦ÌM), E.cloacae (MIC >87 ¦ÌM), S.enterica (MIC=84 ¦ÌM);##Fungus: C.tropicalis (MIC=17 ¦ÌM)."	"[Ref.23624072]70% hemolytic activity at 16 ¦ÌM, 100% hemolytic activity at 32 ¦ÌM, 100% hemolytic activity at 64 ¦ÌM against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	23624072##24184590	Peptides 45:28-34(2013)##Peptides 51:35-45(2014	"Zeng X.C., Zhou L., Shi W., Luo X., Zhang L., Nie Y., Wang J., Wu S.,Cao B., Cao H.##Almaaytah A., Albalas Q."	Three new antimicrobial peptides from the scorpion Pandinusimperator.##Scorpion venom peptides with no disulfide bridges: a review.
DRAMP03850	FALALKALKKALKKLKKALKKAL	23	Antibacterial peptide/melittin homolog	No entry found	Not found	Not found	Synthetic construct 	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8714745	Scanning Microsc. 1995 Jun;9(2):501-507.	"Henk WG, Todd WJ, Enright FM, Mitchell PS."	"The morphological effects of two antimicrobial peptides, hecate-1 and melittin, on Escherichia coli."
DRAMP03872	FQWQRNMRKV	10	"hLf 21-30 (fragment of human lalctoferricin, residues 21-30)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>300 ?M), Escherichia coli (wild strain) (MIC>300 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>300 ?M), Enterococcus faecalis ATCC 29212 (MIC>300 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03873	LRWQNEMRKV	10	"mLf 20-29 (fragment of murine lalctoferricin, residues 20-29)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>300 ?M), Escherichia coli (wild strain) (MIC>300 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>300 ?M), Enterococcus faecalis ATCC 29212 (MIC>300 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03874	RQWQSKIRRT	10	"pLf20-29 (fragment of porcine lactoferricin, residues 20-29)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>300 ?M), Escherichia coli (wild strain) (MIC>300 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>300 ?M), Enterococcus faecalis ATCC 29212 (MIC>300 ?M)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	13677384	Am J Vet Res. 2003 Sep;64(9):1088-1092.	"Chen PW, Shyu CL, Mao FC."	Antibacterial activity of short hydrophobic and basic-rich peptides.
DRAMP03941	RFPWWWPFLR	10	Peptide 3 (Trp- and Arg-rich; derivative of Tritrpticin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Rich	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Pseudomonas, Klebsiella, Proteus species;##Gram-positive bacteria: Streptococcus, Staphylococcus species. "	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8706838	FEBS Lett. 1996 Jul 15;390(1):95-98.	"Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K."	Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides.
DRAMP03942	RRRFPWVCWPFLRRR	15	Peptide 2 (Trp- and Arg-rich; derivative of Tritrpticin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Rich	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis;##Gram-positive bacteria: Staphylococcus epidermidis, Streptococcus group D.##Fungi: Aspergillus fumigatus."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8706838	FEBS Lett. 1996 Jul 15;390(1):95-98.	"Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K."	Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides.
DRAMP03943	VXLFPKKPFLXV	12	Gratisin analogue	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Its activity against Pseudomonas aeruginosa IFO 3080 was two times higher than gramicidin S.	Gram-negative bacterium: Pseudomonas aeruginosa IFO 3080.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18305357	J Antibiot (Tokyo). 2008 Jan;61(1):33-35.	"Tamaki M, Kokuno M, Suzuki Y, Iwama M, Shindo M, Uchida Y."	A novel polycationic analogue of gratisin with antibiotic activity against both Gram-positive and Gram-negative bacteria.
DRAMP03946	GLIKIVPAMICAVTKKC	17	Del 1-3 (Ranalexin analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-positive bacterium: Staphylococcus aureus (MIC>256 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC>256 ?g/ml), Pseudomonas aeruginosa (MIC>256 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8144672	J Biol Chem. 1994 Apr 8;269(14):10849-10855.	"Clark DP, Durell S, Maloy WL, Zasloff M."	"Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin."
DRAMP03961	KRIVQRIKDFLR	12	KR-12	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-positive bacterium: Bacillus megaterium.##Gram-negative bacterium: Escherichia coli.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18818205	J Biol Chem. 2008 Nov 21;283(47):32637-32643.	Wang G.	Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.
DRAMP02092	FLPAIAGMAAKFLPKIFCAISKKC	24	"Brevinin-1Bb (Frogs, amphibians, animals)"	P82834	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana berlandieri (Rio Grande leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=1 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=3 ¦ÌM).##Yeast: Candida albicans (MIC=10 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP18189	IFGAIWKGISSLL	13	"Pantinin-2 (Non-disulfide-bridged peptide 4.21, NDBP-4.21, Non-disulfide-bridged peptide 5.22, ND"	R4JQZ0	 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short an	Not found	Pandinus imperator (Emperor scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Amphipathic peptide that possesses relatively strong activities against Gram-positive bacteria and a fungus, but has very weak antimicrobial activities against Gram-negative bacteria. Also exhibits mild hemolytic activities against human erythrocytes.Forms an alpha-helical membrane channel in the prey."	"[Ref.23624072]Gram-positive bacteria: S.aureus (MIC=48 ¦ÌM), B.magaterium (MIC=36 ¦ÌM), M.luteus (MIC=18 ¦ÌM ), VRE (MIC=36 ¦ÌM), MRSA (MIC=28 ¦ÌM);##Gram-negative bacteria: E.coli (MIC=48 ¦ÌM), P.putida (MIC >87 ¦ÌM), K.oxytoca (MIC >87 ¦ÌM), E.cloacae (MIC >87 ¦ÌM), S.enterica (MIC=68 ¦ÌM);##Fungus: C.tropicalis (MIC=16 ¦ÌM)."	"[Ref.23624072]10% hemolytic activity at 16 ¦ÌM, 80% hemolytic activity at 32 ¦ÌM, 100% hemolytic activity at 64 ¦ÌM against human red bood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	23624072##24184590	Peptides 45:28-34(2013)##Peptides 51:35-45(2014	"Zeng X.C., Zhou L., Shi W., Luo X., Zhang L., Nie Y., Wang J., Wu S.,Cao B., Cao H.##Almaaytah A., Albalas Q."	Three new antimicrobial peptides from the scorpion Pandinusimperator.##Scorpion venom peptides with no disulfide bridges: a review.
DRAMP04018	ALYKKFKKKLLKSLKRLG	18	Rp-1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	"2RLH, 2RLG resolved by NMR."	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria and the yeast candian 	"Gram-positive bacteria: Staphylococcus, Streptococcus, Bacillus species;##Gram-negative bacteria: Escherichia, Salmonella, Pseudomonas species.##Fungi: Candida and Cryptococcus species."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18712851	Biopolymers. 2009 Jan;91(1):1-13.	"Bourbigot S, Dodd E, Horwood C, Cumby N, Fardy L, Welch WH, Ramjan Z, Sharma S, Waring AJ, Yeaman MR, Booth V."	Antimicrobial peptide RP-1 structure and interactions with anionic versus zwitterionic micelles.
DRAMP04037	LKLLKKL	7	Immobilized peptide E07LKK	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04038	LKLLKKLLKLLKKL	14	Immobilized peptide E14LKK/H14LKK	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922 (MBC=1496 ?g/ml), Klebsiella pneumoniae ATCC 4352 (MBC=1496 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923 (MBC=1496 ?g/ml), Bacillus subtilis ATCC 6051 (MBC=1995 ?g/ml).##Yeast: Candida albicans ATCC 10231 (MBC=3200 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04039	LKLLKKLLKLLKKLGK	16	Immobilized peptige E16KGL/H16KGL	No entry found	Not found	Not found	Synthetic construct 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04040	LKLLKKLLKLLKKLGGK	17	Immobilized peptide E17KGG	No entry found	Not found	Not found	Synthetic construct 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04041	LKLLKKLLKLLKKLGGGK	18	Immobilized peptide E18KGG	No entry found	Not found	Not found	Synthetic construct 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04042	KGLKKLLKLLKKLLKL	16	Immobilized peptide E16LKL	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04043	LKKLLKKLKK	10	Immobilized peptid E10KKL	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04044	LKKLLKKLKKLL	12	Immobilized peptid E12LLK	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04045	LKKLLKKLKKLLKK	14	Immobilized peptid E14KKL	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04046	SNMIEGVFAKGFKKASHLFKGIG	23	Immobilized peptide E23GIG magainin2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04047	SNMIEGVFAKGFKKASH	17	Immobilized peptide E17HSA magainin 2 deletion	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria.	"Gram-negative bacteria: Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 4352;##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 and ATCC 25923, Bacillus subtilis ATCC 6051.##Yeast: Candida albicans ATCC 10231."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7726486	Antimicrob Agents Chemother. 1995 Feb;39(2):301-307.	"Haynie SL, Crum GA, Doele BA."	Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.
DRAMP04172	WLKKW	5	LK2W2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC>80 ?g/ml), S. aureus (MIC>80 ?g/ml), S. epidermis (MIC>80 ?g/ml), M. luteus (MIC>80 ?g/ml), S. aureus (MRSA) (MIC>80 ?g/ml).##Gram-negative bacteria: E. coli (MIC>80 ?g/ml), S. dysentariae (MIC>80 ?g/ml), S. typhimorium (MIC>80 ?g/ml), K. pneumoniae (MIC>80 ?g/ml), P. aeruginosa (MIC>80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04173	WLLKW	5	L2KW2 (LlKmW2 model peptides)	No entry found	Not found	Not found	Synthetic construct (De novo design)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.
Chemical modification: C-terminal amidation."	"Gram-positive bacteria: B. subtilis (MIC>80 ?g/ml), S. aureus (MIC>80 ?g/ml), S. epidermis (MIC>80 ?g/ml), M. luteus (MIC>80 ?g/ml), S. aureus (MRSA) (MIC>80 ?g/ml).##Gram-negative bacteria: E. coli (MIC>80 ?g/ml), S. dysentariae (MIC>80 ?g/ml), S. typhimorium (MIC>80 ?g/ml), K. pneumoniae (MIC>80 ?g/ml), P. aeruginosa (MIC>80 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20736034	Regul Pept. 2011 Jan 17;166(1-3):36-41.	"Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS."	De novo generation of short antimicrobial peptides with simple amino acid composition.
DRAMP04198	RQIRIWFQNRRMRWRR	16	PenArg	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=8 ¦ÌM)	[Ref.23085001] HC50>128 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04200	RQIKIWFQNRRLKWKK	16	PenLeu	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=64 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=32 ¦ÌM)	[Ref.23085001] HC50>128 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04201	KIWFQNRRMKWKK	13	Pen13	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=256 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=128 ¦ÌM)	[Ref.23085001] HC50>128 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04202	RIWFQNRRMRWRR	13	Pen13Arg	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=32 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=32 ¦ÌM)	[Ref.23085001] HC50>128 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04203	KIWFQNKKMKWKK	13	Pen13Lys	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=256 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=256 ¦ÌM)	[Ref.23085001] HC50>128 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04204	RWFKIQMQIRRWKNKK	16	PenShuf	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=64 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=32 ¦ÌM)	[Ref.23085001] HC50>128 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04205	RWFKIQLQIRRWKNKK	16	PenShufLeu	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=32 ¦ÌM)	[Ref.23085001] HC50=65¡À2.5 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04206	KWFKIQLQIKKWKNKK	16	PenShufLysLeu	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=32 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=32 ¦ÌM)	[Ref.23085001] HC50=91¡À2.3 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04207	RWFRIQLQIRRWRNRR	16	PenShufArgLeu	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=16 ¦ÌM)	[Ref.23085001] HC50=39¡À1.4 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23085001	Biochim Biophys Acta. 2013 Feb;1828(2):223-232.  doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM."	Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
DRAMP04236	GLFDKLKSLVSDF	13	Antibacterial peptide A2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix (1 helices; 10 residues)	Not found	1VM2 resolved by NMR.	Function: Has antibacterial activity against the Gram-negative bacterium E. coli.	Gram-negative bacterium: Escherichia coli (MIC>250 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15572363	J Biol Chem. 2005 Feb 18;280(7):5803-5811.	"Wang G, Li Y, Li X."	Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor.
DRAMP04266	KWKSFIKKLPSAAKKVTTAAKPLTK	25	CP¦Á1	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=43 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=64 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=24 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=16 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04267	KWKKFIKKIGIGAVLKVLTTGLPALKLTKK	30	CP¦Á2	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=2 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04268	KKWKKFIKKIGIGAVLTTPGAKK	23	CP¦Á3	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=4 ¦Ìg/ml), Salmonella typhimurium (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=64 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=16 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04269	KWKSFIKNLTKGGSKILTTGLPALIS	26	CP201	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=4 ¦Ìg/ml), Salmonella typhimurium (MIC=43 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=64 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=32 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04270	KWKKFIKNLTKGGSKILTTGLPALIS	26	CP202	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=19 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=16 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04271	KWKSFIKKLTSAAKKVLTTGLPALIS	26	CP203	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=5 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=8 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04274	KKWWKFIKKAVNSGTTGLQTLAS	23	CP206	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=8 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04275	KWKSFIKKLTSVLKKVVTTAKPLISS	26	CP207	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=5 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=8 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04276	KKKSFIKLLTSAKVSVLTTAKPLISS	26	CP208	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=64 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04277	WKVFKSFIKKASSFAQSVLD	20	CP209	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=11 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=64 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04280	KWKSFIKKLPSAAKKVVTTAKPLALIS	27	CM1	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=5 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=16 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04281	KWKSFIKKLPKAAKKVVTTAKKPLIV	26	CM2	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=4 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04282	KWKKFIKSLTKSAAKTVVKTAKKPLIV	27	CM3	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=1 ¦Ìg/ml), Salmonella typhimurium (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=2 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04283	KWKLFKKIGIGAVLKVLTTGLPALKLTLK	29	CM4	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=3 ¦Ìg/ml), Salmonella typhimurium (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=4 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04284	KLFKKIGIGAVLKVLTTGLPALKLTK	26	CM5	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=5 ¦Ìg/ml), Salmonella typhimurium (MIC=29 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=19 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=32 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04285	KWKFKKIGIGAVLKVLTTGLPALKLTLK	28	CM6	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=6 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=5 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=2 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04286	KLWKLFKKIGIGAVLKVLTTGLPALKLTK	29	CM7	No entry found	"Derived from the peptide CP26, CP29, CEME and CEMA"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=32 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Lipopolysaccharide (LPS)-binding	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04336	IGKEFKRIVQRIKDFLRNL	19	IG-19 (residues 13-31 of LL-37)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=8 ¦ÌM)"	[Ref.22521196] MHC10=21.6 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04337	IGKKFKRIVQRIKDFLRNL	19	a1 (IG-19 analogs)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=2 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.22521196] MHC10=13.8 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04338	IGKKFKRIVQRIKKFLRNL	19	a2 (IG-19 analogs)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=2 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=8 ¦ÌM)"	[Ref.22521196] MHC10=11.2 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04339	IGKKFKRIVQRIKKFLRKL	19	a3 (IG-19 analogs)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=2 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.22521196] MHC10=23.7 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04340	IGKKFKRIVKRIKKFLRKL	19	a4 (IG-19 analogs)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.22521196] MHC10=33.2 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04341	IGKLFKRIVQRIKKFLRNL	19	a5 (IG-19 analogs)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.22521196] MHC10=3.0 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04342	IGKLFKRIVQRILKFLRNL	19	a6 (IG-19 analogs)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.22521196] MHC10=1.2 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04343	IGKLFKRIVKRILKFLRKL	19	a7 (IG-19 analogs)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.22521196] MHC10=1.1 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04344	ILKLFKRIVKRILKFLRKL	19	a8 (IG-19 analogs)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=8 ¦ÌM)"	[Ref.22521196] MHC10=1.6 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04345	IGKKWKRIVKRIKKFLRKL	19	a4-W1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=4 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.22521196] MHC10=9.2 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04346	IGKKFKRIVKRIKKWLRKL	19	a4-W2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	All of the peptides exhibited a predominantly-helical structure characterized by double minima at 208 and 222 nm in the presence of LPS.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.22521196] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=4 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.22521196] MHC10=8.4 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22521196	Peptides. 2012 Jun;35(2):239-247.	"Nan YH, Bang JK, Jacob B, Park IS, Shin SY."	Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.
DRAMP04357	KWKLFKKIGIGAVLKVLTTGLIALIS	26	CEME(MBI-27)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=5 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=2 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04358	KWKLFKKIGIGAVLKVLTPGLPALKLTK	28	CEMA(MBI-28)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli (MIC=2 ¦Ìg/ml), Salmonella typhimurium (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa K799 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa Z61 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H744 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H374 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa H547 (MIC=4 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10085049	Infect Immun. 1999 Apr;67(4):2005-2009.	"Scott MG, Yan H, Hancock RE."	Biological properties of structurally related alpha-helical cationic antimicrobial peptides.
DRAMP04366	INWSSIFESVSNLV	14	PDD-A-8 (PDD-A analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC>100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04375	INSLKLGKKILGAL	14	PDD-B-5 (PDD-B analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC>100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04384	KIASIGKEVLKAL	13	PMM-5 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC>100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04388	INWKKIASIGKEV	13	PMM-9 (PMM analog)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli.
Chemical modification: C-terminal amidation."	Gram-negative bacterium: Escherichia coli (MIC>100 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC>100 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18375018	Peptides. 2008 Jun;29(6):992-1003.	"Cerovsk? V, Slaninov¨¢ J, Fuc¨ªk V, Hulacov¨¢ H, Borovickov¨¢ L, Jezek R, Bedn¨¢rov¨¢ L."	New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.
DRAMP04658	IKIPPIVKDTLKKVAKGVLSTIAGALST	28	Hymenochirin-5B	No entry found	Not found	Not found	Hymenochirus boettgeri(Congo dwarf clawed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Antimicrobial activity against both Gram-positive, Gram-negative bacteria and fungi."	Gram-positive bacterium: Staphylococcus aureus  (MIC=80 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=40 ¦ÌM);##Fungi: Candida albicans (MIC=160 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22497805	Peptides. 2012 Jun;35(2):269-275.	"Mechkarska M, Prajeep M, Coquet L, Leprince J, Jouenne T, Vaudry H, King JD, Conlon JM."	The hymenochirins: A family of host-defense peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae).
DRAMP04659	FKRLKKLFKKIWNWK	15	HPA3NT3(Derived from HP (2¨C20))	No entry found	Not found	Not found	Helicobacter pylori	"Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal"	Not found	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli"	"[Ref.19642077] Gram-positive bacteria : Staphylococcus aureus(MIC=4 ¦ÌM), Bacillus subtilis(MIC=4 ¦ÌM), Listeria monocytogenes(MIC=22 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=4 ¦ÌM), Salmonella typhimurium(MIC=2 ¦ÌM), Pseudomonas aeruginosa(MIC=2 ¦ÌM);##Fungi : Candida albicans(MIC=8 ¦ÌM), Trichosporon beigelli(MIC=2-4 ¦ÌM)"	"[Ref.19642077] 32% hemolysis at 50 ¦ÌM , 46% hemolysis at 100 ¦ÌM , 70% hemolysis at 200 ¦ÌM against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22982494##19642077	Biochim Biophys Acta. 2013 Feb;1828(2):443-454.##J Pept Sci.?2009 Sep;15(9):589-94. doi: 10.1002/psc.1155.	"Lee JK, Park SC, Hahm KS, Park Y.##Gopal R, Park SC, Ha KJ, Cho SJ, Kim SW, Song PI, Nah JW, Park Y, Hahm KS"	Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.##Effect of Leucine and Lysine substitution on the antimicrobial activity and evaluation of the mechanism of the HPA3NT3 analog peptide.
DRAMP04660	AKRLKKLFKKIWNWK	15	HPA3NT3-F1A (HPA3NT3 peptide analogs)	No entry found	Not found	Not found	Helicobacter pylori	"Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus"	"[Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=2 ¦ÌM), Listeria monocytogenes(MIC=2 ¦ÌM), Staphylococcus epidermidis(MIC=2-4 ¦ÌM), Bacillus subtilis(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=4 ¦ÌM), Pseudomonas aeruginosa(MIC=1 ¦ÌM), Primula vulgaris(MIC=4 ¦ÌM), Salmonella typhimurium(MIC=1 ¦ÌM);##Fungi : Candida albicans(MIC=8 ¦ÌM), Trichosporon beigelii(MIC=16 ¦ÌM), Aspergillus awamori(MIC=16 ¦ÌM), Aspergillus flavus(MIC=16 ¦ÌM), Aspergillus fumigatus(MIC=8 ¦ÌM), Aspergillus parasiticus(MIC=8 ¦ÌM)"	[Ref.22982494] 7.1% hemolysis at 250 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22982494	Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005	"Lee JK, Park SC, Hahm KS, Park Y."	Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.
DRAMP04661	FKRLKKLAKKIWNWK	15	HPA3NT3-F8A (HPA3NT3 peptide analogs)	No entry found	Not found	Not found	Helicobacter pylori	"Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus"	"[Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=4 ¦ÌM), Listeria monocytogenes(MIC=2 ¦ÌM), Staphylococcus epidermidis(MIC=2-4 ¦ÌM), Bacillus subtilis(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=4 ¦ÌM), Pseudomonas aeruginosa(MIC=2 ¦ÌM), Primula vulgaris(MIC=4 ¦ÌM), Salmonella typhimurium(MIC=2 ¦ÌM);##Fungi : Candida albicans(MIC=8 ¦ÌM), Trichosporon beigelii(MIC=16 ¦ÌM), Aspergillus awamori(MIC=16 ¦ÌM), Aspergillus flavus(MIC=16 ¦ÌM), Aspergillus fumigatus(MIC=8 ¦ÌM), Aspergillus parasiticus(MIC=8 ¦ÌM)"	[Ref.22982494] 4.6% hemolysis at 250 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22982494	Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005	"Lee JK, Park SC, Hahm KS, Park Y."	Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.
DRAMP04662	AKRLKKLAKKIWNWK	15	HPA3NT3-F1AF8A (HPA3NT3 peptide analogs)	No entry found	Not found	Not found	Helicobacter pylori	"Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus"	"[Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=16 ¦ÌM), Listeria monocytogenes(MIC=2 ¦ÌM), Staphylococcus epidermidis(MIC=16 ¦ÌM), Bacillus subtilis(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=32 ¦ÌM), Pseudomonas aeruginosa(MIC=2 ¦ÌM), Primula vulgaris(MIC=4 ¦ÌM), Salmonella typhimurium(MIC=2 ¦ÌM);##Fungi : Candida albicans(MIC=16 ¦ÌM), Trichosporon beigelii(MIC=32 ¦ÌM), Aspergillus awamori(MIC=16 ¦ÌM), Aspergillus flavus(MIC=32 ¦ÌM), Aspergillus fumigatus(MIC=4 ¦ÌM), Aspergillus parasiticus(MIC=8 ¦ÌM)"	[Ref.22982494] 0% hemolysis at 250 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22982494	Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005	"Lee JK, Park SC, Hahm KS, Park Y."	Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.
DRAMP04663	AKRLKKLAKKIWKWL	15	HPA3NT3-A1 (HPA3NT3 peptide analogs)	No entry found	Not found	Not found	Helicobacter pylori	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus"	"[Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=16 ¦ÌM), Listeria monocytogenes(MIC=16 ¦ÌM), Staphylococcus epidermidis(MIC=8 ¦ÌM), Bacillus subtilis(MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=32 ¦ÌM), Pseudomonas aeruginosa(MIC=32 ¦ÌM), Primula vulgaris(MIC=8-16 ¦ÌM), Salmonella typhimurium(MIC=8 ¦ÌM);##Fungi : Candida albicans(MIC=16 ¦ÌM), Trichosporon beigelii(MIC>128 ¦ÌM), Aspergillus awamori(MIC=64 ¦ÌM), Aspergillus flavus(MIC=64 ¦ÌM), Aspergillus fumigatus(MIC=16 ¦ÌM), Aspergillus parasiticus(MIC=16 ¦ÌM)"	[Ref.22982494] 20.9% hemolysis at 250 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22982494	Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005	"Lee JK, Park SC, Hahm KS, Park Y."	Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.
DRAMP04664	AKRLKKLAKKIWKWK	15	HPA3NT3-A2 (HPA3NT3 peptide analogs)	No entry found	Not found	Not found	Helicobacter pylori	"Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus"	"[Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=4 ¦ÌM), Listeria monocytogenes(MIC=2 ¦ÌM), Staphylococcus epidermidis(MIC=2-4 ¦ÌM), Bacillus subtilis(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=4 ¦ÌM), Pseudomonas aeruginosa(MIC=2 ¦ÌM), Primula vulgaris(MIC=2-4 ¦ÌM), Salmonella typhimurium(MIC=2 ¦ÌM);##Fungi : Candida albicans(MIC=8 ¦ÌM), Trichosporon beigelii(MIC=16 ¦ÌM), Aspergillus awamori(MIC=8 ¦ÌM), Aspergillus flavus(MIC=8 ¦ÌM), Aspergillus fumigatus(MIC=4 ¦ÌM), Aspergillus parasiticus(MIC=8 ¦ÌM)"	[Ref.22982494] 0% hemolysis at 250 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22982494	Biochim Biophys Acta. 2013 Feb;1828(2):443-454.  doi: 10.1016/j.bbamem.2012.09.005	"Lee JK, Park SC, Hahm KS, Park Y."	Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.
DRAMP18188	GILGKLWEGFKSIV	14	"Pantinin-1 (Non-disulfide-bridged peptide 4.20, NDBP-4.20, Non-disulfide-bridged peptide 5.21, ND"	R4JNJ5	 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short an	Not found	Pandinus imperator (Emperor scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Homology	Not found	Not found	None	"Function: Amphipathic peptide that possesses relatively strong activities against Gram-positive bacteria and a fungus, but has very weak antimicrobial activities against Gram-negative bacteria. Also exhibits very low hemolytic activities against human erythrocytes.Forms an alpha-helical membrane channel in the prey."	"[Ref.23624072]Gram-positive bacteria: S.aureus (MIC=8 ¦ÌM), B.magaterium (MIC=32 ¦ÌM), M.luteus (MIC=32 ¦ÌM ), VRE (MIC=28 ¦ÌM), MRSA (MIC=14 ¦ÌM);##Gram-negative bacteria: E.coli (MIC=62 ¦ÌM), P.putida (MIC >87 ¦ÌM), K.oxytoca (MIC >87 ¦ÌM), E.cloacae (MIC=76 ¦ÌM), S.enterica (MIC=72 ¦ÌM);##Fungus: C.tropicalis (MIC=16 ¦ÌM)."	"[Ref.23624072]0% hemolytic activity at 16 ¦ÌM, 0% hemolytic activity at 32 ¦ÌM, 20% hemolytic activity at 64 ¦ÌM against human red bood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membrane	23624072##24184590	Peptides 45:28-34(2013)##Peptides 51:35-45(2014	"Zeng X.C., Zhou L., Shi W., Luo X., Zhang L., Nie Y., Wang J., Wu S.,Cao B., Cao H.##Almaaytah A., Albalas Q."	Three new antimicrobial peptides from the scorpion Pandinusimperator.##Scorpion venom peptides with no disulfide bridges: a review.
DRAMP04684	NKPEALVDYTGVXNS	15	Bacteriocin BAC-IB17	C0HJE5	Not found	Not found	Bacillus subtilis	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Has bactericidal activity.
Miscellaneous: On the 2D-gel the determined pI of this protein is: 7.0, its MW is: 10.7 kDa."	"Gram-positive bacteria: M. luteus, methicillin-resistant S. aureus, methicillin-sensitive S. aureus and B. stearothermophilus;##Gram- negative bacteria: E. coli, S. typhi."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	PubMed ID is not available	Submitted (AUG-2013) to UniProtKB	"Ansari A, Siddiqui NN, Zohra RR, Aman A, Qader SA."	"Isolation, purification and characterization of bacteriocin (BAC-IB17) produced from Bacillus subtilis KIBGE-IB17."
DRAMP04700	DLWQFGKMILKVAGKLPFPYYGAYGCYCGWGGRGKPKDPTDRCCFVHDCC	50	"Basic phospholipase A2 BnpTX-1 (BnPTx-I, svPLA2; Phosphatidylcholine 2-acylhydrolase)"	P0DM51	Belongs to the phospholipase A2 family (Group II subfamily D49 sub-subfami	Not found	Bothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedipauloensis)	"Antimicrobial, Antibacterial, Antiparasitic, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Snake venom phospholipase A2 (PLA2). In vitro, shows anticoagulant activity and induces cytotoxicity when tested on C2C12 myoblasts/myotubes. In vivo, when tested on mice, induces myotoxicity (intramuscular injection), edema (injection in the subplantar region) and lethality. Also induces neurotoxic effect on mouse neuromuscular preparations and has bactericidal activity on the Gram-negative bacteria E.coli (ATCC29648) and the Gram- positive S.aureus (ATCC 25923). The catalytic and anticoagulant activities of BnpTX-I are higher than those of BnpTX-II. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Toxic Dose: LD(50) is 5.1 +/- 1.3 mg/kg by intraperitoneal injection into mice. LD(50) is 2.3 +/- 0.8 mg/kg by intravenous injection into mice.
Miscellaneous: Has a pI of approximately 7.8 and about 121 amino acids (PubMed:15302537).
PTM: Contains seven disulfide bonds."	Gram-negative bacterium: E. coli ATCC29648 and Gram-positive bacterium: S. aureus ATCC 25923.	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15302537	Toxicon. 2004 Sep 1;44(3):305-314.	"Rodrigues VM, Marcussi S, Cambraia RS, de Ara¨²jo AL, Malta-Neto NR, Hamaguchi A, Ferro EA, Homsi-Brandeburgo MI, Giglio JR, Soares AM."	Bactericidal and neurotoxic activities of two myotoxic phospholipases A2 from Bothrops neuwiedi pauloensis snake venom.
DRAMP18187	IWLTALKFLGKNLGKHLAKQQLAKL	25	Toxin LyeTx 1	C0HJU9	Not found	Not found	Lycosa erythrognatha (Spider) (Scaptocosa raptoria)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Has hemolytic activity against rabbit erythrocytes. Forms pores in lipid bilayers in vitro; pore formation is reduced when cholesterol is present in the bilayers.	"[Ref.19946788]Gram-positive bacterium: S.aureus (MIC=3.79 ¦ÌM);##Gram-negative bacterium: E.coli (MIC=7.81 ¦ÌM);##Yeasts: C.krusei (MIC=26.3 ¦ÌM), C.neoformans (MIC=13.2 ¦ÌM)."	[Ref.19946788]ED50=1.3 ¡Á 10?4 M against rabbit erythrocytes	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19946788	Amino Acids 39:135-144(2010)	"Santos D.M., Verly R.M., Pilo-Veloso D., de Maria M.,de Carvalho M.A., Cisalpino P.S., Soares B.M., Diniz C.G.,Farias L.M., Moreira D.F., Frezard F., Bemquerer M.P., Pimenta A.M.,de Lima M.E."	"LyeTx I, a potent antimicrobial peptide from the venom of the spiderLycosa erythrognatha."
DRAMP18128	SGTSEKERESGRLLGVVKRLIVGFRSPFR	29	Antimicrobial peptide HsAp4; 	P0DMJ0	Not found	Not found	Heterometrus spinifer (Asia giant forest scorpion) (Malaysian blackscorpion)	"Antimicrobial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Possesses antimicrobial activity against both Gram- negative and Gram-positive bacteria, as well as against the fungus C. tropicaliS. Also possess a relatively high hemolytic activity (By similarity)."	"[Ref.23000095]Gram-positive bacteria: Staphylococcus aureus AB 94004 (MIC=23.6?M), Bacillus magaterium AB 90008 (MIC=11.8?M), Bacillus thuringiensis AB 93100 (MIC=46.5?M);##Gram-negative bacteria: Salmonella enterica AB 2010185 (MIC=25.0?M), E. coli DH5 (MIC=51.2?M), E. coli JM109 (MIC=50.4?M), Enterobacter cloacae subsp. cloacae AB 2010162 (MIC=47.9?M), Klebsiella oxytoca AB 2010143 (MIC=50.5?M);##Fungi: Candida tropicalis AY 91009 (MIC=48.6?M)."	"[Ref.23000095]5% hemolytic activity at 0.8 ¦ÌM, 35% hemolytic activity at 1.6 ¦ÌM, 95% hemolytic activity at 3.2 ¦ÌM, 100% hemolytic activity against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23000095	Peptides 38:389-394 (2012).	"Nie Y., Zeng X.C. , Yang Y., Luo F., Luo X., Wu S. , Zhang L., Zhou J."	A novel class of antimicrobial peptides from the scorpionHeterometrus spinifer.
DRAMP18129	SGTPEKERESGRLLGVVKRYIVCVRNPCP	29	Antimicrobial peptide HsAp3; 	P0DMI9	Not found	Not found	Heterometrus spinifer (Asia giant forest scorpion) (Malaysian blackscorpion)	"Antimicrobial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Possesses antimicrobial activity against both Gram- negative and Gram-positive bacteria, as well as against the fungus C. tropicali. Also possess a relatively high hemolytic activity (By similarity)."	"[Ref.23000095]Gram-positive bacteria: Staphylococcus aureus AB 94004 (MIC=23.6¦ÌM), Bacillus magaterium AB 90008 (MIC=11.8¦ÌM), Bacillus thuringiensis AB 93100 (MIC=46.5¦ÌM);##Gram-negative bacteria: Salmonella enterica AB 2010185 (MIC=25.0¦ÌM), E. coli DH5 (MIC=51.2¦ÌM), E. coli JM109 (MIC=50.4¦ÌM), Enterobacter cloacae subsp. cloacae AB 2010162 (MIC=47.9¦ÌM), Klebsiella oxytoca AB 2010143 (MIC=50.5¦ÌM);##Fungi: Candida tropicalis AY 91009 (MIC=48.6¦ÌM)."	"[Ref.23000095]5% hemolytic activity at 0.8 ¦ÌM, 35% hemolytic activity at 1.6 ¦ÌM, 95% hemolytic activity at 3.2 ¦ÌM, 100% hemolytic activity against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23000095	Peptides 38:389-394 (2012).	"Nie Y., Zeng X.C. , Yang Y., Luo F., Luo X., Wu S. , Zhang L., Zhou J."	A novel class of antimicrobial peptides from the scorpionHeterometrus spinifer.
DRAMP18130	SGTSEKERESERLLGVVNPLIKCFRSPCP	29	Antimicrobial peptide HsAp2	P0DMI8	Not found	Not found	Heterometrus spinifer (Asia giant forest scorpion) (Malaysian blackscorpion)	"Antimicrobial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Possesses antimicrobial activity against both Gram- negative and Gram-positive bacteria, as well as against the fungus C. tropicaliS. Also possess a relatively high hemolytic activity (By similarity)."	"[Ref.23000095]Gram-positive bacteria: Staphylococcus aureus AB 94004 (MIC=23.6¦ÌM), Bacillus magaterium AB 90008 (MIC=11.8¦ÌM), Bacillus thuringiensis AB 93100 (MIC=46.5¦ÌM);##Gram-negative bacteria: Salmonella enterica AB 2010185 (MIC=25.0¦ÌM), E. coli DH5 (MIC=51.2¦ÌM), E. coli JM109 (MIC=50.4¦ÌM), Enterobacter cloacae subsp. cloacae AB 2010162 (MIC=47.9¦ÌM), Klebsiella oxytoca AB 2010143 (MIC=50.5¦ÌM);##Fungi: Candida tropicalis AY 91009 (MIC=48.6¦ÌM)."	"[Ref.23000095]5% hemolytic activity at 0.8 ¦ÌM, 35% hemolytic activity at 1.6 ¦ÌM, 95% hemolytic activity at 3.2 ¦ÌM, 100% hemolytic activity against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23000095	Peptides 38:389-394 (2012).	"Nie Y., Zeng X.C. , Yang Y., Luo F., Luo X., Wu S. , Zhang L., Zhou J."	A novel class of antimicrobial peptides from the scorpionHeterometrus spinifer.
DRAMP18131	SGTSEKERESGRLLGVVKRLIVCFRSPFP	29	Antimicrobial peptide HsAp1 (HsAp)	P0DMI7	Not found	Not found	Heterometrus spinifer (Asia giant forest scorpion) (Malaysian blackscorpion)	"Antimicrobial, Antifungal, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	Function: Possesses antimicrobial activity against both Gram- negative and Gram-positive. Also possess a relatively high hemolytic activity.	"[Ref.23000095]Gram-positive bacteria: Staphylococcus aureus AB 94004 (MIC=23.6¦ÌM), Bacillus magaterium AB 90008 (MIC=11.8¦ÌM), Bacillus thuringiensis AB 93100 (MIC=46.5¦ÌM);##Gram-negative bacteria: Salmonella enterica AB 2010185 (MIC=25.0¦ÌM), E. coli DH5 (MIC=51.2¦ÌM), E. coli JM109 (MIC=50.4¦ÌM), Enterobacter cloacae subsp. cloacae AB 2010162 (MIC=47.9¦ÌM), Klebsiella oxytoca AB 2010143 (MIC=50.5¦ÌM);##Fungi: Candida tropicalis AY 91009 (MIC=48.6¦ÌM)."	"[Ref.23000095]5% hemolytic activity at 0.8 ¦ÌM, 35% hemolytic activity at 1.6 ¦ÌM, 95% hemolytic activity at 3.2 ¦ÌM, 100% hemolytic activity against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23000095	Peptides 38:389-394 (2012).	"Nie Y., Zeng X.C. , Yang Y., Luo F., Luo X., Wu S. , Zhang L., Zhou J."	A novel class of antimicrobial peptides from the scorpionHeterometrus spinifer.
DRAMP18185	FLPLFLPKIICVITKKC	17	Jingdongin-1	K7ZGS2	 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily	Not found	Amolops jingdongensis (Chinese torrent frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function: Has activity against Gram- negative bacterium and exhibits hemolytic activity. 	"[Ref.22828809]Gram-negative bacterium: B.dysenteriae (MIC=35 ¦Ìg/ml);##Gram-positive bacteria: S.aureus ATCC 2592 (MIC=4.7 ¦Ìg/ml), B.subtilis ATCC 6633 (MIC=9.38 ¦Ìg/ml);##Fungus: C.albicans (MIC=18.75 ¦Ìg/ml)"	"[Ref.22828809] It exhibits hemolysis of 1.32%, 5.37%, 6.35%, 16.55% at 25 ¦Ìg/ml, 50 ¦Ìg/ml, 100 ¦Ìg/ml, 200 ¦Ìg/ml against rabbit red blood cells"	Cyclic	Free	Cyclization(Cys11 and Cys17).	Disulfide bond between Cys11 and Cys17.	L	No cytotoxicity information found	Not found	22828809	Amino Acids 44:481-487(2013)	"He X., Yang S., Wei L., Liu R., Lai R., Rong M."	"Antimicrobial peptide diversity in the skin of the torrent frog,Amolops jingdongensis."
DRAMP03018	INMKASAAVAKKLL	14	"MP-VB1 (Insects, animals)"	No entry found	Not found	Not found	vespine wasps Vespa bicolor	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Has antimicrobial activities against standard strains and strong antimicrobial ability against drug-resistant strains. Among the tested drug-resistant strains, Pseudemonas aeruginosa and Staphylococcus aureus were the most sensitive for this kind of antimicrobial peptide. Has a little hemolytic activity."	"[Ref.18723059] Gram-negative bacterium: Escherichia coli ATCC25922(MIC=15.0¦Ìg/ml), Escherichia coli 23A(MIC=15.0¦Ìg/ml), Escherichia coli 27A(MIC=60.0¦Ìg/ml), Pseudemonas aeruginosa 3A(MIC=15.0¦Ìg/ml), Pseudemonas aeruginosa 7A(MIC=120.0¦Ìg/ml), ;## Gram-positive bacterium: Staphylococcus aureus ATCC2592(MIC=3.75¦Ìg/ml), Staphylococcus aureus 6A(MIC=1.9¦Ìg/ml), Staphylococcus aureus 15A(MIC=3.75¦Ìg/ml);## Fungus: Candida albicans ATCC2002(MIC=15.0¦Ìg/ml)"	[Ref.18723059] MP-VB1 had almost no hemolytic activity of 1.7% and 2.7% against rabbit and human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	18723059	Peptides. 2008 Nov;29(11):1887-1892.	"Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, Yu H."	Antimicrobial peptides from the venoms of Vespa bicolor Fabricius.
DRAMP01875	GLMSLFRGVLKTAGKHIFKNVGGSLLDQAKCKITGEC	37	"Brevinin-2PRa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana pirica (Hokkaido frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: activity against reference strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae) and Gram-positive (Staphlococcus aureus) bacteria but displayed relatively low hemolytic activity. "	"[Ref.15003829] Gram-negative bacterium: Escherichia coli(MIC=6¦ÌM), Pseudemonas aeruginosa(MIC=3¦ÌM), Enterobacter cloacae(MIC=6¦ÌM), Klebsiella pneumoniae(MIC=6¦ÌM);## Gram-positive bacterium: Staphylococcus aureus(MIC=25¦ÌM);## Yeast: Candida albicans(MIC>100¦ÌM)"	[Ref.15003829] HC50=55 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	15003829	Regul Pept. 2004 May 15;118(3):135-141.	"Conlon JM, Sonnevend A, Patel M, Al-Dhaheri K, Nielsen PF, Kolodziejek J, Nowotny N, Iwamuro S, P"	"A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica."
DRAMP01876	GLMSLFRGGVLKTAGKHIFKNVGGSLLDQAKCKITGEC	38	"Brevinin-2PRb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	Rana pirica (Hokkaido frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: activity against reference strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae) and Gram-positive (Staphlococcus aureus) bacteria but displayed relatively low hemolytic activity. "	"[Ref.15003829] Gram-negative bacterium: Escherichia coli(MIC=3¦ÌM), Pseudemonas aeruginosa(MIC=3¦ÌM), Enterobacter cloacae(MIC=6¦ÌM), Klebsiella pneumoniae(MIC=6¦ÌM);## Gram-positive bacterium: Staphylococcus aureus(MIC=25¦ÌM);## Yeast: Candida albicans(MIC>100¦ÌM)"	[Ref.15003829] HC50=65 ¦ÌM against human erythrocytes	Cyclic	Free	Cyclization (Cys31 and Cys37)	Disulfide bond between Cys31 and Cys37.	L	No cytotoxicity information found	Not found	15003829	Regul Pept. 2004 May 15;118(3):135-141.	"Conlon JM, Sonnevend A, Patel M, Al-Dhaheri K, Nielsen PF, Kolodziejek J, Nowotny N, Iwamuro S, P"	"A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica."
DRAMP18444	RYPAVGYT	8	"Lacrain (myriapods, arthropods, invertebrates, animals)"	No entry found	Not found	Not found	"Brazilian centipede, Scolopendra viridicornis"	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria	"[Ref.27451089]Gram-negative bacteria : Pseudomonas aeruginosa ATCC 27853 (MIC=5.8 ¦Ìg/ml;MBC=11.6 ¦Ìg/ml), Alcaligenes faecalis ATCC 8750 (MIC=5.8 ¦Ìg/ml;MBC=5.8 ¦Ìg/ml), Serratia marcescens ATCC 4112 (MIC=5.8 ¦Ìg/ml;MBC=5.8 ¦Ìg/ml), Enterobacter cloacae ¦Â-12 (MIC=2.9 ¦Ìg/ml;MBC=2.9 ¦Ìg/ml), Salmonella serovars (MIC=5.8 ¦Ìg/ml;MBC=11.6 ¦Ìg/ml), Salmonella enterica subsp. arizonae (MIC=5.8 ¦Ìg/ml;MBC=5.8 ¦Ìg/ml), Escherichia coli SBS363 (MIC=5.8 ¦Ìg/ml;MBC=5.8 ¦Ìg/ml), Escherichia coli D31 (MIC=5.8 ¦Ìg/ml;MBC=5.8 ¦Ìg/ml)"	[Ref.27451089] 0% hemolysis at 0.5-500 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27451089	Int J Antimicrob Agents. 2016 Sep;48(3):277-85. doi: 10.1016/j.ijantimicag.2016.05.015.	"E. Chaparro,P.I. da Silva Junior"	Lacrain: the first antimicrobial peptide from the body extract of the Brazilian centipede Scolopendra viridicornis
DRAMP18449	AVNIPFKVHLRCKAAFC	17	"Kunitzin-OS (amphibians, animals)"	No entry found	Not found	Not found	"Chinese frog, Odorrana schmackeri"	"Antibacterial, Enzyme inhibitor, Anti-Gram-, Antimicrobial"		Not found	Not found	None	Comment: No comments found on DRAMP database	Gram-negative bacteria: E. coli (MIC 20 uM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27311856	Biochem Biophys Res Commun. 2016 Aug 19;477(2):302-9.	"Chen X, Wang H, Shen Y, Wang L, Zhou M, Chen T, Shaw C."	Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs
DRAMP18450	AAKIILNPKFRCKAAFC	17	"Kunitzin-RE (amphibians, animals)"	No entry found	Not found	Not found	"European frog, Rana esculenta"	"Antibacterial, Enzyme inhibitor, Anti-Gram-, Antimicrobial"		Not found	Not found	None	Fuction: A change of the last K to F reduced activity (MIC 160 uM). 	Gram-negative bacteria: E. coli (MIC 30 uM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27311856	Biochem Biophys Res Commun. 2016 Aug 19;477(2):302-9.	"Chen X, Wang H, Shen Y, Wang L, Zhou M, Chen T, Shaw C."	Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs
DRAMP18454	FLPVIAGVLSKLF	13	"Tepmporin-1Ee (frog, amphibians, animals)"	No entry found	Not found	Not found	"skin secretion, the European edible frog, Pelophylax kl. esculentus, Europe."	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	Fuction: It showed no hemolytic activity at 10 ¦ÌM.	[Ref.27255993]Gram-positive bacteria: S. aureus (MIC= 10 ¦ÌM);##Gram-negative bacteria: E. coli (MIC= 40 ¦ÌM)	[Ref.27255993]Non-hemolytic activity at 10 ¦ÌM	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27255993	Biochem Biophys Res Commun. 2016 Aug 5;476(4):566-73.	"Chen X, Wang H, Yang M, Wang L, Zhou M, Chen T, Shaw C."	"Identification and bioactivity evaluation of two novel temporins from the skin secretion of the European edible frog, Pelophylax kl. esculentus."
DRAMP18456	FSLIPSAIGGLISA	18	"Pepcon (peptide consensus sequence, synthetic)"	No entry found	Not found	Not found	Designed based on sequence alignment with scorpion linear peptides	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"		Not found	Not found	None	Comment: No comments found on DRAMP database	"Gram-positive bacteria: S. epidermidis ATCC 12228 (MIC 7.5 uM),S. aureus (5 uM);##Gram-negative bacteria: E. coli ATCC 25922 (MIC 50 uM), S. enterica ATCC 10708 (60 uM), P. aeruginosa ATCC 27853 (40uM), A. baumannii ATCC 19606 (MIC 20 uM),K. pneumoniae (60 uM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28096686	Infect Drug Resist. 2016 Dec 29;10:1-17.	"Almaaytah A, Ajingi Y, Abualhaijaa A, Tarazi S, Alshar'i N, Al-Balas Q"	Peptide consensus sequence determination for the enhancement of the antimicrobial activity and selectivity of antimicrobial peptides.
DRAMP18471	KKLALKALLLWLKALLKLAKLALKK	25	D-LAK60	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Peptides comprising all D-amino acids.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC>22.62 ¦ÌM), Escherichia coli Top 10 (MIC=7.07¡À2.04 M), Pseudomonas aeruginosa (MIC>22.62 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18472	KKLALKALKLWLLALLKLAKLALKK	25	D-LAK80	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Peptides comprising all D-amino acids.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC>22.62 ¦ÌM), Escherichia coli Top 10 (MIC=5.40¡À1.01 ¦ÌM), Pseudomonas aeruginosa (MIC>22.62 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18473	KKLALKALKLWLLALKKLALLALKK	25	D-LAK100	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Peptides comprising all D-amino acids.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=4.14¡À1.03 ¦ÌM), Escherichia coli Top 10 (MIC=1.51¡À0.23 M), Pseudomonas aeruginosa (MIC=7.92¡À2.06 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18474	KKLAKLALLKWLLALKKLALLALKK	25	D-LAK140	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Peptides comprising all D-amino acids.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=3.14¡À1.28 ¦ÌM), Escherichia coli Top 10 (MIC=0.76¡À0.18 M), Pseudomonas aeruginosa (MIC=4.69¡À0.67 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18475	KKLAKLALLKWLLALKLLALKALKK	25	D-LAK160	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Peptides comprising all D-amino acids.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=3.85¡À0.64 ¦ÌM), Escherichia coli Top 10 (MIC=1.49¡À0.56 ¦ÌM), Pseudomonas aeruginosa (MIC=6.23¡À0.71 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18476	KKLAKALKLLALLWLKLAKALKKA	24	LAK80	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=13.05¡À0.13 ¦ÌM)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18477	KKLAKAPKLLALLWLKLAKALKKA	24	LAK80-P7	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=2.97¡À0.15 ¦ÌM), Escherichia coli Top 10 (MIC=1.26¡À0.49 ¦ÌM), Pseudomonas aeruginosa (MIC=2.13¡À0.77 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18478	KKLAKALKLPALLWLKLAKALKKA	24	LAK80-P10	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.62¡À0.17 ¦ÌM), Escherichia coli Top 10 (MIC=0.82¡À0.03 ¦ÌM), Pseudomonas aeruginosa (MIC=1.18¡À0.53 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18479	KKLAKALKLLAPLWLKLAKALKKA	24	LAK80-P12	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.80¡À0.27 ¦ÌM), Escherichia coli Top 10 (MIC=0.80¡À0.01 ¦ÌM), Pseudomonas aeruginosa (MIC=0.86¡À0.09 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18480	KKLALALKKLALLWKKLALALKKA	24	LAK120	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=2.95¡À0.06 ¦ÌM), Escherichia coli Top 10 (MIC=1.47¡À0.64 ¦ÌM), Pseudomonas aeruginosa (MIC=4.20¡À0.92 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18481	KKLALAPKKLALLWKKLALALKKA	24	LAK120-P7	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=0.80¡À0.03 ¦ÌM), Escherichia coli Top 10 (MIC=0.45¡À0.10 ¦ÌM), Pseudomonas aeruginosa (MIC=4.45¡À0.19 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18482	KKLALALKKPALLWKKLALALKKA	24	LAK120-P10	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=0.78¡À0.01 ¦ÌM), Escherichia coli Top 10 (MIC=0.47¡À0.15 ¦ÌM), Pseudomonas aeruginosa (MIC=9.16¡À1.43 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18483	KKLALALKKLAPLWKKLALALKKA	24	LAK120-P12	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=0.97¡À0.06 ¦ÌM), Escherichia coli Top 10 (MIC=0.68¡À0.14 ¦ÌM), Pseudomonas aeruginosa (MIC=2.14¡À0.53 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18484	KKLKLALAKLALLWKALALKLKKA	24	LAK160	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.11¡À0.48 ¦ÌM), Escherichia coli Top 10 (MIC=0.73¡À0.40 ¦ÌM), Pseudomonas aeruginosa (MIC=2.23¡À0.41 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18485	KKLKLAPAKLALLWKALALKLKKA	24	LAK160-P7	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=0.79¡À0.41 ¦ÌM), Escherichia coli Top 10 (MIC=0.46¡À0.11 ¦ÌM), Pseudomonas aeruginosa (MIC=2.98¡À0.21 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18486	KKLKLALAKPALLWKALALKLKKA	24	LAK160-P10	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=2.22¡À0.63 ¦ÌM), Escherichia coli Top 10 (MIC=0.45¡À0.24 ¦ÌM), Pseudomonas aeruginosa (MIC=4.14¡À0.23 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18487	KKLKLALAKLAPLWKALALKLKKA	24	LAK160-P12	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=0.48¡À0.20 ¦ÌM), Escherichia coli Top 10 (MIC=0.38¡À0.08 ¦ÌM), Pseudomonas aeruginosa (MIC=1.69¡À0.09 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ¦Á-helical peptides."
DRAMP18488	FFGSLLSLGSKLLPSVFKLFQRKKE	25	"Css54 (Css from the species name below; scorpions, arachnids, Chelicerata, arthropods, invertebra"	P0DL41	Not found	Not found	Centruroides suffusus (Mexican scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytolysis, Hemolytic"	Not found	Not found	Not found	None	"Function: Amphipathic peptide that shows antibacterial activity against Escherichia coli and Staphylococcus aureus. Increases efficacy of antibiotics when tested against S.aureus, probably by facilitating their incorporation into the bacteria. Has hemolytic activity against human erythrocytes."	[Ref.23093034]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ¦Ìg/ml);##Gram-negative bacterium: Escherichia coli (MIC=12.5 ¦Ìg/ml).	"[Ref.23093034]30% hemolytic activity at 9 ¦ÌM, 67% hemolytic activity at 17 ¦ÌM against human erythrocytes"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23093034	J Antibiot (Tokyo). 2013 Jan;66(1):3-10.	"Garcia F, Villegas E, Espino-Solis GP, Rodriguez A, Paniagua-Solis JF, Sandoval-Lopez G, Possani LD, Corzo G."	Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics.
DRAMP02081	FLPLLAGLAANFLPKIFCKITRKC	24	"Brevinin-1E (Frogs, amphibians, animals)"	P32412 	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana esculenta (Edible frog) (Pelophylax esculentus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Anti Mammalian Cells"	Protein level	Alpha helix	Possess an intramo-lecular disulfide bridge located at the  carboxyl-terminal end.	None	"Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity."	"[Ref.8163497] Gram-negative bacteria: Escherichia coliD21 (MIC=1.8 ?M), Pseudomonas aeruginosa ATCC15692 (MIC=30.6 ?M);##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.4 ?M), Staphylococcus aureus Cowan1 (MIC=0.6 ?M);##Fungi: Candida albicans (MIC=4.7 ?M);##Yeast: Saccharomyces cerevisiae (MIC=3.8 ?M)."	[Ref.8163497] LC50=0.5 ?M against human red blood cell.	Cyclic	Free	Cyclization (Cys18 and Cys24)	Disulfide bond between Cys18 and Cys24.	L	No cytotoxicity information found	Not found	8508915##8163497	FEBS Lett. 1993 Jun 14;324(2):159-161.##J Biol Chem. 1994 Apr 22;269(16):11956-11961. 	"Simmaco M, Mignogna G, Barra D, Bossa F.##Simmaco M, Mignogna G, Barra D, Bossa F."	Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta.##Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
DRAMP02751	GRPNPVNNKPTPHPRL	16	"Formaecin-1 (Pro-rich; ants, insects, animals)"	P81438	Not found	Not found	Myrmecia gulosa (Red bulldog ant)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Rich	Not found	None	"Function: Antibacterial activity against E.coli but none against other Gram-negative bacteria and Gram-positive bacteria.
Induction: By bacterial infection.
PTM: O-linked glycan consists of a Gal-GalNAc disaccharide, O-glycosylation is essential for full biological activity."	"[Ref.9497332] Gram-negative bacteria: Escherichia coli NCTC 8196, Escherichia coli BLR."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9497332	J Biol Chem. 1998 Mar 13;273(11):6139-6143.	"Mackintosh JA, Veal DA, Beattie AJ, Gooley AA."	Isolation from an ant Myrmecia gulosa of two inducible O-glycosylated proline-rich antibacterial peptides.
DRAMP02752	GRPNPVNTKPTPYPRL	16	"Formaecin-2 (Pro-rich; ants, insects, animals)"	P81437 	Not found	Not found	Myrmecia gulosa (Red bulldog ant)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Rich	Not found	None	"Function: Antibacterial activity against E.coli but none against other Gram-negative bacteria and Gram-positive bacteria.
Induction: By bacterial infection.
PTM: O-linked glycan consists of a Gal-GalNAc disaccharide, O-glycosylation is essential for full biological activity."	"[Ref.9497332] Gram-negative bacteria: Escherichia coli NCTC 8196, Escherichia coli BLR."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9497332	J Biol Chem. 1998 Mar 13;273(11):6139-6143.	"Mackintosh JA, Veal DA, Beattie AJ, Gooley AA."	Isolation from an ant Myrmecia gulosa of two inducible O-glycosylated proline-rich antibacterial peptides.
DRAMP03097	GKPRPYSPRPTSHPRPIRV	19	"Drosocin (Glycopeptide,insects, arthropods, invertebrates, animals)"	P36193	Belongs to the drosocin family	Dro	Drosophila melanogaster (Fruit fly)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Beta turns	"The NMR data clearly indicate a difference between the glycosylated and nonglycosylated forms, i.e., in the perturbation of a turn directly adjacent to the glycosylation site."	4EZR resolved by X-ray.	"Function: Antibacterial peptide with strong anti-Gram-negative bacteria activity.
PTM: O-glycosylation is essential for full biological activity.
Tissue specificity: In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following two weeks.
Developmental stage: Expressed in larvae and in adults.
Induction: By bacterial infection."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9888811##8325867##9497332	"Biochemistry. 1999 Jan 12;38(2):705-14.##
J Biol Chem. 1993 Jul 15;268(20):14893-7.##J Biol Chem. 1998 Mar 13;273(11):6139-6143."	"McManus AM, Otvos L Jr, Hoffmann R, Craik DJ.##
Bulet P, Dimarcq JL, Hetru C, Lagueux M, Charlet M, Hegy G, Van Dorsselaer A, Hoffmann JA.##Mackintosh JA, Veal DA, Beattie AJ, Gooley AA."	"Conformational studies by NMR of the antimicrobial peptide, drosocin, and its non-glycosylated derivative: effects of glycosylation on solution conformation.##A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution.##Isolation from an ant Myrmecia gulosa of two inducible O-glycosylated proline-rich antibacterial peptides."
DRAMP03575	FKRIVQRIKDFLR	13	"LL-37(17-29) (C-terminal fragment of LL-37, LL; Human, mammals, animals)"	P49913	Belongs to truncated LL-37.	Not found	Homo sapiens	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer"	Protein level	Alpha helix##Random coil	Not found	2FBS resolved by NMR.	"Function: LL-37(17-29) became slightly less active than the longer ones, indicating that the truncated hydrophobic residues L31 and V32 also play a role in interaction with human cells. Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria."	"[Ref.16637646] Gram-negative bacterium: Escherichia coli K12(MIC=40 ¦ÌM);##Drug-resistant KBv cancer cells (LC50=60 ¦ÌM), Drug-sensitive KB cancer cells (LC50=57 ¦ÌM).##[Ref.28178190]Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=16 ¦ÌM), S. faecalis ATCC 29212 (MIC=32 ¦ÌM), Bacillus subtilis CMCC 63501 (MIC=16 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=8 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 ¦ÌM), Escherichia coli UB 1005 (MIC=16 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=16 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC=32 ¦ÌM), Salmonella typhimurium ATCC 7731 (MIC=16 ¦ÌM). [Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)"	[Ref.28161291] HC50>256 ¦ÌM against human red blood cells. [Ref.23894079] MHC10=160 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16637646##28178190##28161291##23894079	J Am Chem Soc. 2006 May 3;128(17):5776-5785.##Int J Mol Sci. 2017 Feb 6;18(2). pii: E339. ##Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733.##ChemMedChem.?2013 Oct;8(10):1638-42.	"Li X, Li Y, Han H, Miller DW, Wang G. ##Tan T, Wu D, Li W, Zheng X, Li W, Shan A.##Rajasekaran G,?Kim EY,?Shin SY##Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	"Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. ##High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7.##LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity. ##Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides."
DRAMP02094	FLPAIAGVAAKFLPKIFCAISKKC	24	"Brevinin-1Bd (Frogs, amphibians, animals)"	P82836	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana berlandieri (Rio Grande leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=3 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=7 ¦ÌM).##Yeast: Candida albicans (MIC=7 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02095	FLPAIVGAAAKFLPKIFCVISKKC	24	"Brevinin-1Be (Frogs, amphibians, animals)"	P82837	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana berlandieri (Rio Grande leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against  Gram-positive and Gram-negative bacteria.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=3 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=15 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02096	FLPFIAGMAANFLPKIFCAISKKC	24	"Brevinin-1Bf (Frogs, amphibians, animals)"	P82838	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana berlandieri (Rio Grande leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against  Gram-positive and Gram-negative bacteria.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=8 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=19 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02097	FLPIIAGVAAKVFPKIFCAISKKC	24	"Brevinin-1Pa (Frogs, amphibians, animals)"	P82841	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pipiens (Northern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=7 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=14 ¦ÌM).##Yeast: Candida albicans (MIC=5 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02098	FLPIIASVAAKVFSKIFCAISKKC	24	"Brevinin-1Pc (Frogs, amphibians, animals)"	P82843	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pipiens (Northern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=7 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=5 ¦ÌM).##Yeast: Candida albicans (MIC=7 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02099	FLPIIASVAANVFSKIFCAISKKC	24	"Brevinin-1Pd (Frogs, amphibians, animals)"	P82844	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pipiens (Northern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity: Expressed by the skin glands."	[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=27 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC=78 ¦ÌM).##Yeast: Candida albicans (MIC=29 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02255	GILSSIKGVAKGVAKNVAAQLLDTLKCKITGC	32	"Ranatuerin-2Lb (Ranatuerin 2Lb; Ranaturin-2PRd; Frogs, amphibians, animals)"	P82829	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana luteiventris (Spotted frog) (Rana pretiosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	[Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli (MIC=4 ?M);##Yeast: Candida albicans (MIC=62 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02254	GILDSFKGVAKGVAKDLAGKLLDKLKCKITGC	32	"Ranatuerin-2La (Ranatuerin 2La; Ranatuerin-2PRa; Frogs, amphibians, animals)"	P82828	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana luteiventris (Spotted frog) (Rana pretiosa)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	[Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=11 ?M);##Gram-negative bacterium: Escherichia coli (MIC=4 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02256	GLLDTIKGVAKTVAASMLDKLKCKISGC	28	"Ranatuerin-2B (Ranatuerin 2B, Frog, amphibians, animals)"	P82840 	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana berlandieri (Rio Grande leopard frog) (Rana luteiventris)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	[Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M);##Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Yeast: Candida albicans (MIC=35 ?M).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10651828	Eur J Biochem. 2000 Feb;267(3):894-900.	"Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP02257	LMDTVKNVAKNLAGHMLDKLKCKITGC	27	"Ranatuerin-2P (Ranatuerin 2P; Frogs, amphibians, animals)"	"Q8QFQ4, P82847"	Belongs to the frog skin active peptide family (Brevinin subfamily)	Not found	Rana pipiens (Northern leopard frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal,Antiviral"	Protein level	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	[Ref.10651828] Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Yeast: Candida albicans (MIC=67 ?M).##[Ref.11601906]Virus:##Frog Virus 3: 90% inhibition at 500 ?M;##Channel Catfish Virus: 99% inhibition at 50 ?M.	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Cyclization of a C-terminal Cys residue (forming a disulfide bond)	There is a disulfide bond between Cys22 and Cys27.	L	No cytotoxicity information found in the reference(s) presented	Not found	11601906##10651828	Virology. 2001 Sep 30;288(2):351-7.##Eur J Biochem. 2000 Feb;267(3):894-900.	"Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.##Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM."	"Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.##Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens."
DRAMP18497	WKSDVRRWRSRY	12	TSG-6 (Ixosin-B peptide derivative)	No entry found	Derived from Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity,"	"[Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC>100 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=64 ¦ÌM), Pseudomonas aeruginosa (MIC>100 ¦ÌM)"	[Ref.23570790]0.3¡À0.9% hemolysis at 100¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23570790	Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.	"Wu YS, Liao ZJ, Wang KS, Lung FD."	Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.
DRAMP18498	WKSYVRRWRSRY	12	TSG-7 (Ixosin-B peptide derivative)	No entry found	Derived from Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive  and Gram-negative bacteria. Has hemolytic activity	"[Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC=32 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=16 ¦ÌM), Pseudomonas aeruginosa (MIC=100 ¦ÌM)"	[Ref.23570790]1.5¡À1.4% hemolysis at 100¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23570790	Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.	"Wu YS, Liao ZJ, Wang KS, Lung FD."	Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.
DRAMP18499	WKSYVRRWRSR	11	TSG-8 (Ixosin-B peptide derivative)	No entry found	Derived from Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC=32 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=16 ¦ÌM), Pseudomonas aeruginosa (MIC>100 ¦ÌM)"	[Ref.23570790]-1.2¡À2.6% hemolysis at 100¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23570790	Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.	"Wu YS, Liao ZJ, Wang KS, Lung FD."	Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.
DRAMP18500	WWSYVRRWRSR	11	TSG-8-1 (Ixosin-B peptide derivative)	No entry found	Derived from Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC=8 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=16 ¦ÌM), Pseudomonas aeruginosa (MIC>100 ¦ÌM)"	[Ref.23570790]3.4¡À1.3% hemolysis at 100¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23570790	Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.	"Wu YS, Liao ZJ, Wang KS, Lung FD."	Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.
DRAMP18501	WKSYVRRWRS	10	TSG-9 (Ixosin-B peptide derivative)	No entry found	Derived from Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC>100 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=64 ¦ÌM), Pseudomonas aeruginosa (MIC>100 ¦ÌM)"	[Ref.23570790]-0.4¡À0.5% hemolysis at 100¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23570790	Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.	"Wu YS, Liao ZJ, Wang KS, Lung FD."	Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.
DRAMP18502	WKSYVRRWR	9	TSG-10 (Ixosin-B peptide derivative)	No entry found	Derived from Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC=64 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=64 ¦ÌM), Pseudomonas aeruginosa (MIC>100 ¦ÌM)"	[Ref.23570790]1.1¡À1.3% hemolysis at 100¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23570790	Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.	"Wu YS, Liao ZJ, Wang KS, Lung FD."	Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.
DRAMP18503	WKSYVRRW	8	TSG-11 (Ixosin-B peptide derivative)	No entry found	Derived from Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC=100 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=64 ¦ÌM), Pseudomonas aeruginosa (MIC>100 ¦ÌM)"	[Ref.23570790]2.0¡À0.3% hemolysis at 100¦ÌM against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23570790	Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.	"Wu YS, Liao ZJ, Wang KS, Lung FD."	Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.
DRAMP18504	FSEAIKKIIDFLGEGLFDIIKKIAESF	27	E(AU)2 (Aurein 1.2 peptide derivative)	No entry found	Derived from Aurein 1.2	Not found	Litoria raniformis (Southern bell frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Coiled coil	Not found	None	"Function: Antibacterial activity against Gram-negative bacteria, E(AU)2 has no hemolytic activity"	[Ref.23519707]Gram-negative bacterium: Escherichia coli (MIC=128 ¦Ìmol/L)	"[Ref.23519707]~5% hemolysis at 128¦Ìmol/L, 0% hemolysis at 4 -32¦Ìmol/L against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23519707	Amino Acids. 2013 Jun;44(6):1521-8.	"Lorenz¨®n EN, Sanches PR, Nogueira LG, Bauab TM, Cilli EM."	"Dimerization of aurein 1.2: effects in structure, antimicrobial activity and aggregation of C?ndida albicans cells"
DRAMP18505	GLFDIIKKIAESFKFSEAIKKIIDFLG	27	(AU)2K (Aurein 1.2 peptide derivative)	No entry found	Derived from Aurein 1.2	Not found	Litoria raniformis (Southern bell frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Alpha helix 	Not found	None	"Function: Antibacterial activity against Gram-negative bacteria, Has hemolytic activity."	[Ref.23519707]Gram-negative bacterium: Escherichia coli (MIC=128 ¦Ìmol/L)	"[Ref.23519707]~30% hemolysis at 32¦Ìmol/L, 10% hemolysis at 4 ¦Ìmol/L against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23519707	Amino Acids. 2013 Jun;44(6):1521-8.	"Lorenz¨®n EN, Sanches PR, Nogueira LG, Bauab TM, Cilli EM"	"Dimerization of aurein 1.2: effects in structure, antimicrobial activity and aggregation of C?ndida albicans cells"
DRAMP18506	KKFFLKVLTKIRCKVAGGCRT	21	OG2 (Palustrin-OG1 peptide derivative)	No entry found	Derived from Palustrin-OG1	Not found	Synthetic construct (Modified Palustrin-OG1)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive, Gram-negative bacteria, and lower hemolytic activity than OG1."	"[Ref.22670762]Gram-positive bacteria: Bacillus subtilis 1A751 (MIC=128 ¦Ìg/mL), Staphylococcus aureus ATCC25923 (MIC=8 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=8 ¦Ìg/mL),Salmonella choleraesuis CMCC50020 (MIC=16 ¦Ìg/mL)"	[Ref.22670762]7%¡À2% hemolysis at 2-256 ¦Ìg/mL against porcine red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22670762	Protein Pept Lett. 2013 Jan;20(1):54-60.	"Xie YG, Luan C, Zhang HW, Han FF, Feng J, Choi YJ, Groleau D, Wang YZ."	Effects of thioredoxin: SUMO and intein on soluble fusion expression of an antimicrobial peptide OG2 in Escherichia coli.
DRAMP18508	KFAKKFKWFAKAAFKFFKK	19	gp41w-FKA (gp41 peptide derivative)	No entry found	"Derived from the HIV glycoprotein, gp41"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	"gp41w-FKA peptide to adopt a helical conformation in the cosolvent mixture of chloroform, methanol and water. The peptide formed a very well defined "	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.23019445]Gram-positive bacterium: Staphylococcus aureus (MIC<10 ¦Ìg/ml, MBC=20-30 ¦Ìg/ml);##Gram-negative bacterium: Escherichia coli (MIC=10-30 ¦Ìg/ml, MBC=40-50 ¦Ìg/ml)"	[Ref.23019445]EC50=195 ¦Ìg/mL against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	gp41w-FKA binds at the interfacial region of a phospholipid bilayer.	23019445	Beilstein J Org Chem. 2012;8:1172-84. Epub 2012 Jul 24.	"Haney EF, Nguyen LT, Schibli DJ, Vogel HJ."	"Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41."
DRAMP18509	MAFKKLEKVGRNIRDGIIKAGPAVAVIGQATSIARPTGK	39	Px-cec1 (cecropin1 peptide derivative)	No entry found	Derived from the cecropin1	cecropin1	Diamondback moth(Plutella xylostella)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. No hemolytic activity."	"[Ref.22921836]Gram-positive bacteria: Staphylococcus aureus
 (MIC=2.1 ¦Ìg/mL), Bacillus cereus (MIC=2.6 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli K12D31 (MIC=0.1 ¦Ìg/mL), Escherichia coli K12 (MIC=0.23 ¦Ìg/mL), Pseudomonas fluorescent (MIC=1.1 ¦Ìg/mL), Salmonella choleraesuis (MIC=2.1 ¦Ìg/mL);##Fungi: Aureobasidium pullulans (MIC=4.0 ¦Ìg/mL), Aspergillus flavus (MIC=14.5 ¦Ìg/mL), Aspergillus fumigatus (MIC=16.0 ¦Ìg/mL), Aspergillus niger (MIC=14.6 ¦Ìg/mL), Fusarium oxysporum (MIC=8.0 ¦Ìg/mL)"	[Ref.22921836]Non-hemolytic against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22921836	Protein Expr Purif. 2012 Oct;85(2):230-8.	"Jin F, Sun Q, Xu X, Li L, Gao G, Xu Y, Yu X, Ren S."	"cDNA cloning and characterization of the antibacterial peptide cecropin 1 from the diamondback moth, Plutella xylostella L."
DRAMP18510	KKLALLALKKWLLALKKLALLALKK	25	D-LAK120	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antiplasmodial activity. Peptides comprising all D-amino acids. Has hemolytic activity.	"[Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.48¡À0.53 ¦ÌM), Escherichia coli Top 10 (MIC=0.62¡À0.15 ¦ÌM), Pseudomonas aeruginosa (MIC=2.71¡À1.07 ¦ÌM);##Plasmodium: Plasmodium falciparum 3D7 (EC50=1.95¡À0.08 ¦ÌM)"	[Ref.22869378]HC50=4.06¡À1.30 ¦ÌM against Not found (The literature does not mention)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic "
DRAMP18511	KKLALLALKKWLPALKKLALLALKK	25	D-LAK120-P13	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antiplasmodial activity. Peptides comprising all D-amino acids. Has hemolytic activity.	"[Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.54¡À0.97 ¦ÌM), Escherichia coli Top 10 (MIC=0.58¡À0.18 ¦ÌM), Pseudomonas aeruginosa (MIC=1.42¡À0.41 ¦ÌM);##Plasmodium: Plasmodium falciparum 3D7 (EC50=0.88¡À0.08 ¦ÌM), Plasmodium falciparum C10 (EC50=2.18¡À0.41 ¦ÌM), A549 (EC50=2.44¡À0.43 ¦ÌM), RAW264.7 (EC50=3.80¡À0.34 ¦ÌM)"	[Ref.22869378]HC50=11.66¡À0.03 ¦ÌM against Not found (The literature does not mention)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic "
DRAMP18512	KKLALALAKKWLALAKKLALALAKK	25	D-LAK120-A	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antiplasmodial activity. Peptides comprising all D-amino acids. Has hemolytic activity.	"[Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.23¡À0.47 ¦ÌM), Escherichia coli Top 10 (MIC=0.38¡À0.21 ¦ÌM), Pseudomonas aeruginosa (MIC=1.83¡À0.63 ¦ÌM);##Plasmodium: Plasmodium falciparum 3D7 (EC50=1.45¡À0.12 ¦ÌM), Plasmodium falciparum C10 (EC50=2.13¡À0.14 ¦ÌM), A549 (EC50=5.23¡À0.35 ¦ÌM), RAW264.7 (EC50=7.31¡À2.13 ¦ÌM)"	[Ref.22869378]HC50=17.42¡À2.17 ¦ÌM against Not found (The literature does not mention)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic "
DRAMP18513	KKLALALAKKWLPLAKKLALALAKK	25	D-LAK120-AP13	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antiplasmodial activity. Peptides comprising all D-amino acids. Has hemolytic activity.	"[Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.08¡À0.62 ¦ÌM), Escherichia coli Top 10 (MIC=0.29¡À0.09 ¦ÌM), Pseudomonas aeruginosa (MIC=1.22¡À0.19 ¦ÌM);##Plasmodium: Plasmodium falciparum 3D7 (EC50=0.88¡À0.06 ¦ÌM), Plasmodium falciparum C10 (EC50=2.36¡À0.10 ¦ÌM), A549 (EC50=3.11¡À0.57 ¦ÌM), RAW264.7 (EC50=3.42¡À0.16 ¦ÌM)"	[Ref.22869378]HC50=58.61¡À10.41 ¦ÌM against Not found (The literature does not mention)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic "
DRAMP18514	KKLALHALKKWLHALKKLAHLALKK	25	D-LAK120-H 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antiplasmodial activity. Peptides comprising all D-amino acids. Has hemolytic activity.	"[Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.54¡À0.01 ¦ÌM), Escherichia coli Top 10 (MIC=0.40¡À0.01 ¦ÌM), Pseudomonas aeruginosa (MIC=1.35¡À0.07 ¦ÌM);##Plasmodium: Plasmodium falciparum 3D7 (EC50=1.26¡À0.14 ¦ÌM), Plasmodium falciparum C10 (EC50=4.43¡À0.33 ¦ÌM), A549 (EC50=4.54¡À0.30 ¦ÌM), RAW264.7 (EC50=5.21¡À0.57 ¦ÌM)"	[Ref.22869378]HC50=20.29¡À2.42 ¦ÌM against Not found (The literature does not mention)	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22869378	J Biol Chem. 2012 Oct 5;287(41):34120-33.	"Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ."	"Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic "
DRAMP18515	KWKSFLkTFKSLKKTVLHTLLKAISS	26	A12L/A20L (V13KL peptide derivative)	No entry found	Derived from the framework peptide V13KL	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. A12L/A20L against HeLa cells. Leucine to replace Alanine at the position 12 and 20 on the peptide V13KL. Has hemolytic activity.	"[Ref.17158938]Gram-negative bacteria: Pseudomonas aeruginosa PAO1(MIC=62.5 ¦Ìg/ml), Pseudomonas aeruginosa WR5 (MIC=125 ¦Ìg/ml), Pseudomonas aeruginosa PAK (MIC=62.5 ¦Ìg/ml), Pseudomonas aeruginosa PA14 (MIC=125 ¦Ìg/ml), Pseudomonas aeruginosa M2 (MIC=62.5 ¦Ìg/ml), Pseudomonas aeruginosa CP204 (MIC=62.5 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=78.7 ¦Ìg/ml).##[Ref.22837667]Cancer cell: HeLa cell (IC50=1.71¡À0.07 ¦Ìmol/L)."	"[Ref.22837667]MHC=8.0 ¦Ìg/ml, MHC=5.20¡À0.02 ¦Ìmol/L against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17158938##22837667	Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.##Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.	"Chen Y, Guarnieri MT, Vasil AI, Vasil ML, Mant CT, Hodges RS.##Huang YB, He LY, Jiang HY, Chen YX."	Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.##Role of helicity on the anticancer mechanism of action of cationic-helical peptides.
DRAMP18516	KWKSFLKTFKSLKkTVLHTLLKAISS	26	K7D (A12L/A20L peptide derivative)	No entry found	Derived from the framework peptide A12L/A20L	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial"	Synthetic	Alpha helix 	Not found	None	Function: K7D against HeLa cells. D-Lysine replace L-Lysine at the position 7 on the polar face of peptide A12L/A20L. Has hemolytic activity.	[Ref.22837667]Cancer cell: HeLa cell (IC50=1.29¡À0.03 ¦Ìmol/L)	[Ref.22837667]MHC=10.4¡À0.04 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22837667	Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849.	"Huang YB, He LY, Jiang HY, Chen YX."	Role of helicity on the anticancer mechanism of action of cationic-helical peptides.
DRAMP18533	KWKSFLKTFKSAKKTVLHTALKAISS	26	V13KL (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. L-Lysine replace L-Valine at the position 13 on the non-polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=64.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=64.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=5.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=1.6 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=64.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.3 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=11.8 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=2.5 ¦Ìg/ml), Escherichia coli DC2 (MIC=1.6 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=4.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=1.3 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=8.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=5.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=3.1 ¦Ìg/ml).##[Ref.17158938]Gram-negative bacteria: Pseudomonas aeruginosa PAO1(MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa WR5 (MIC=250 ¦Ìg/ml), Pseudomonas aeruginosa PAK (MIC=125 ¦Ìg/ml), Pseudomonas aeruginosa PA14 (MIC=62.5 ¦Ìg/ml), Pseudomonas aeruginosa M2 (MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa CP204 (MIC=7.8 ¦Ìg/ml), The geometric mean of MIC values above six Pseudomonas aeruginosa strains (MIC=49.6 ¦Ìg/ml)"	[Ref.17158938]MHC=250.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462##17158938	J Biol Chem. 2005 Apr 1;280(13):12316-29.##Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS.##Chen Y, Guarnieri MT, Vasil AI, Vasil ML, Mant CT, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.##Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.
DRAMP18534	KWKSFLKTFKSAKKTVLHTALKLISS	26	A23L (V13KL peptide derivative)	No entry found	Derived from the framework peptide V13KL	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Leucine to replace Alanine at the position 23 on the peptide V13KL. Has hemolytic activity.	"[Ref.17158938]Gram-negative bacteria: Pseudomonas aeruginosa PAO1(MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa WR5 (MIC=62.5 ¦Ìg/ml), Pseudomonas aeruginosa PAK (MIC=62.5 ¦Ìg/ml), Pseudomonas aeruginosa PA14 (MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa M2 (MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa CP204 (MIC=15.6 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=35.1 ¦Ìg/ml)"	[Ref.17158938]MHC=62.5 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17158938	Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.	"Chen Y, Guarnieri MT, Vasil AI, Vasil ML, Mant CT, Hodges RS."	Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.
DRAMP18535	KWKSFLKTFKSLKKTVLHTALKAISS	26	A12L (V13KL peptide derivative)	No entry found	Derived from the framework peptide V13KL	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Leucine to replace Alanine at the position 12 on the peptide V13KL. Has hemolytic activity.	"[Ref.17158938]Gram-negative bacteria: Pseudomonas aeruginosa PAO1(MIC=15.6 ¦Ìg/ml), Pseudomonas aeruginosa WR5 (MIC=62.5 ¦Ìg/ml), Pseudomonas aeruginosa PAK (MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa PA14 (MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa M2 (MIC15.6= ¦Ìg/ml), Pseudomonas aeruginosa CP204 (MIC=15.6 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=24.8 ¦Ìg/ml)"	[Ref.17158938]MHC=31.3 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17158938	Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.	"Chen Y, Guarnieri MT, Vasil AI, Vasil ML, Mant CT, Hodges RS."	Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.
DRAMP18536	KWKSFLKTFKSAKKTVLHTLLKAISS	26	A20L (V13KL peptide derivative)	No entry found	Derived from the framework peptide V13KL	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Leucine to replace Alanine at the position 20 on the peptide V13KL. Has hemolytic activity.	"[Ref.17158938]Gram-negative bacteria: Pseudomonas aeruginosa PAO1(MIC=7.8 ¦Ìg/ml), Pseudomonas aeruginosa WR5 (MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa PAK (MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa PA14 (MIC=15.6 ¦Ìg/ml), Pseudomonas aeruginosa M2 (MIC=15.6 ¦Ìg/ml), Pseudomonas aeruginosa CP204 (MIC=7.7 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=15.6 ¦Ìg/ml)"	[Ref.17158938]MHC=31.3 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17158938	Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.	"Chen Y, Guarnieri MT, Vasil AI, Vasil ML, Mant CT, Hodges RS."	Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.
DRAMP18537	KWKSFLKTFKSLKKTVLHTALKLISS	26	A12L/A23L (V13KL peptide derivative)	No entry found	Derived from the framework peptide V13KL	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Leucine to replace Alanine at the position 12 and 23 on the peptide V13KL. Has hemolytic activity.	"[Ref.17158938]Gram-negative bacteria: Pseudomonas aeruginosa PAO1(MIC=15.6 ¦Ìg/ml), Pseudomonas aeruginosa WR5 (MIC=250 ¦Ìg/ml), Pseudomonas aeruginosa PAK (MIC=15.6 ¦Ìg/ml), Pseudomonas aeruginosa PA14 (MIC=62.5 ¦Ìg/ml), Pseudomonas aeruginosa M2 (MIC=31.3 ¦Ìg/ml), Pseudomonas aeruginosa CP204 (MIC=7.8 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=31.2 ¦Ìg/ml)"	[Ref.17158938]MHC=15.6 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	17158938	Antimicrob Agents Chemother. 2007 Apr;51(4):1398-406.	"Chen Y, Guarnieri MT, Vasil AI, Vasil ML, Mant CT, Hodges RS."	Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.
DRAMP18538	KWKSFLKTFKSAVKTVLHTALKAISS	26	V681	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=16.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=9.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=5.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.2 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=16.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.5 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=6.3 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=7.1 ¦Ìg/ml), Escherichia coli DC2 (MIC=4.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=20.2 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=5.7 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=6.4 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=20.2 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=8.8 ¦Ìg/ml)"	[Ref.15677462]MHC=15.6 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18539	KWKSFLKTFKSALKTVLHTALKAISS	26	V13LL (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. L-Leucine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=32.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=25.4 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=8.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=3.2 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=32.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.5 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=10.9 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=6.4 ¦Ìg/ml), Escherichia coli DC2 (MIC=5.0 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=32.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=10.1 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=12.7 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=32.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=12.7 ¦Ìg/ml)"	[Ref.15677462]MHC=7.8 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18540	KWKSFLKTFKSAAKTVLHTALKAISS	26	V13AL (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. L-Alanine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=8.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=5.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=3.2 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.0 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=16.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=4.5 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=2.5 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=6.4 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=2.5 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=5.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=6.4 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=3.8 ¦Ìg/ml)"	[Ref.15677462]MHC=31.2 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18541	KWKSFLKTFKSAGKTVLHTALKAISS	26	V13G (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Glycine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=25.4 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=10.1 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=3.2 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.0 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=50.8 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=7.4 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=2.5 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=5.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=2.5 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=6.4 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=10.1 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=4.1 ¦Ìg/ml)"	[Ref.15677462]MHC=125.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18542	KWKSFLKTFKSASKTVLHTALKAISS	26	V13SL (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. L-Serine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=16.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=12.7 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=4.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.5 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=50.8 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.6 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=7.4 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=2.5 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=6.4 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=2.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=6.4 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=10.1 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=4.2 ¦Ìg/ml)"	[Ref.15677462]MHC=125.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18543	KWKSFLKTFKSALKTVLHTALKAISS	26	V13LD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Leucine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=5.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=4.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=2.5 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.5 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=6.4 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.6 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=3.3 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=3.2 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=16.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=3.2 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=6.4 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=10.1 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=5.5 ¦Ìg/ml)"	[Ref.15677462]MHC=7.8 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18544	KWKSFLKTFKSAVKTVLHTALKAISS	26	V13VD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Valine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=4.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=3.2 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=1.6 ¦Ìg/ml), Bacillus subtilis C971 (MIC=1.3 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=12.7 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.3 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=2.8 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=2.5 ¦Ìg/ml), Escherichia coli DC2 (MIC=1.6 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=5.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=2.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=4.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=8.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=3.3 ¦Ìg/ml)"	[Ref.15677462]MHC=62.5 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18545	KWKSFLKTFKSAAKTVLHTALKAISS	26	V13AD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Alanine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=8.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=5.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=2.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=1.6 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=32.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.6 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=4.3 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=1.6 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.0 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=5.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=2.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=4.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=10.1 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=3.3 ¦Ìg/ml)"	[Ref.15677462]MHC=250.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18546	KWKSFLKTFKSASKTVLHTALKAISS	26	V13SD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Serine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Weak hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=64.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=64.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=12.7 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.5 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=64.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=16.0 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=3.2 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.0 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=12.7 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=2.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=18.3 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=20.2 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=6.3 ¦Ìg/ml)"	[Ref.15677462]MHC>250.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18547	KWKSFLKTFKSAKKTVLHTALKAISS	26	V13KD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Lysine to replace L-Valine at the position 13 on the non-polar face of peptide V681. Weak hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=64.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=64.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=25.4 ¦Ìg/ml), Bacillus subtilis C971 (MIC=3.2 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=64.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=18.7 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=3.2 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=32.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=1.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=32.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=25.4 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=7.7 ¦Ìg/ml)"	[Ref.15677462]MHC>250.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18548	KWKSFLKTFKLAVKTVLHTALKAISS	26	S11LL (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. L-Leucine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=32.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=32.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=16.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=5.0 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=50.8 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.5 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=14.8 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=16.0 ¦Ìg/ml), Escherichia coli DC2 (MIC=5.0 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=32.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=12.7 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=20.2 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=32.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=16.6 ¦Ìg/ml)"	[Ref.15677462]MHC=4.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18549	KWKSFLKTFKVAVKTVLHTALKAISS	26	S11VL (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. L-Valine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=16.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=12.7 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=8.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.5 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=20.2 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.3 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=6.9 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=6.4 ¦Ìg/ml), Escherichia coli DC2 (MIC=4.0 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=32.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=5.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=10.1 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=20.2 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=9.7 ¦Ìg/ml)"	[Ref.15677462]MHC=7.8 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18550	KWKSFLKTFKAAVKTVLHTALKAISS	26	S11AL (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. L-Alanine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=16.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=12.7 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=4.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.5 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=20.2 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=6.6 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=6.4 ¦Ìg/ml), Escherichia coli DC2 (MIC=4.0 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=20.2 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=4.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=10.1 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=16.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=8.3 ¦Ìg/ml)"	[Ref.15677462]MHC=15.6 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18551	KWKSFLKTFKGAVKTVLHTALKAISS	26	S11G (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Glycine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=8.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=5.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=4.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.0 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=12.7 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=4.5 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=5.0 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=12.7 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=3.2 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=4.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=10.1 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=5.2 ¦Ìg/ml)"	[Ref.15677462]MHC=7.8 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18552	KWKSFLKTFKKAVKTVLHTALKAISS	26	S11KL (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. L-Lysine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=32.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=16.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=6.4 ¦Ìg/ml), Bacillus subtilis C971 (MIC=3.2 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=32.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=4.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=10.5 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=10.1 ¦Ìg/ml), Escherichia coli DC2 (MIC=4.0 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=25.4 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=8.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=25.4 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=32.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=13.7 ¦Ìg/ml)"	[Ref.15677462]MHC=4.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18553	KWKSFLKTFKLAVKTVLHTALKAISS	26	S11LD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Leucine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=8.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=5.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=4.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.0 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=16.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=4.7 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=5.0 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=10.1 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=3.2 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=4.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=10.1 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=5.0 ¦Ìg/ml)"	[Ref.15677462]MHC=31.2 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18554	KWKSFLKTFKVAVKTVLHTALKAISS	26	S11VD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Valine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=16.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=8.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=4.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.5 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=32.0 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=2.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=6.6 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=5.0 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=10.1 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=4.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=6.4 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=16.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=6.1 ¦Ìg/ml)"	[Ref.15677462]MHC=125.0 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18555	KWKSFLKTFKAAVKTVLHTALKAISS	26	S11AD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Alanine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=6.4 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=5.0 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=2.5 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.0 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=12.7 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.6 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=3.8 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=4.0 ¦Ìg/ml), Escherichia coli DC2 (MIC=2.5 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=8.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=2.0 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=5.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=8.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=4.3 ¦Ìg/ml)"	[Ref.15677462]MHC=15.6 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18556	KWKSFLKTFKSAVKTVLHTALKAISS	26	S11SD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Serine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=4.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=2.5 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=2.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=1.3 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=6.4 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=2.3 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=2.5 ¦Ìg/ml), Escherichia coli DC2 (MIC=1.6 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=5.0 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=1.6 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=2.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=10.1 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=2.9 ¦Ìg/ml)"	[Ref.15677462]MHC=15.6 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18557	KWKSFLKTFKKAVKTVLHTALKAISS	26	S11KD (V681 peptide derivative)	No entry found	Derived from the framework peptide V681	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. D-Lysine to replace L-Serine at the position 11 on the polar face of peptide V681. Has hemolytic activity.	"[Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=4.0 ¦Ìg/ml), Staphylococcus aureus SAP0017 (MIC=2.5 ¦Ìg/ml), Staphylococcus epidermidis C621 (MIC=2.0 ¦Ìg/ml), Bacillus subtilis C971 (MIC=2.0 ¦Ìg/ml), Enterococcus faecalis C625 (MIC=12.7 ¦Ìg/ml), Corynebacterium xerosis C875 (MIC=1.0 ¦Ìg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=2.8 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=3.2 ¦Ìg/ml), Escherichia coli DC2 (MIC=1.6 ¦Ìg/ml), Salmonella typhimurium C587 (MIC=3.2 ¦Ìg/ml), Salmonella typhimurium C610 (MIC=1.6 ¦Ìg/ml), Pseudomonas aeruginosa H187 (MIC=2.0 ¦Ìg/ml), Pseudomonas aeruginosa H188 (MIC=6.4 ¦Ìg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=2.6 ¦Ìg/ml)"	[Ref.15677462]MHC=31.2 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15677462	J Biol Chem. 2005 Apr 1;280(13):12316-29.	"Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS."	Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
DRAMP18558	FIKRIARLLRKIF	13	Kn2-7 (BmKn2 peptide derivative)	No entry found	Derived from the peptide BmKn2	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22792229]Gram-positive bacteria: Staphylococcus aureus AB94004 (MIC=3.13 ¦Ìg/ml), Staphylococcus aureus ATCC 25923 (MIC=3.13 ¦Ìg/ml), Bacillus subtilis AB91021 (MIC=6.25 ¦Ìg/ml), Bacillus thuringiensis AB92037 (MIC=6.25 ¦Ìg/ml), Micrococcus luteus AB93113 (MIC=6.25 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=6.25 ¦Ìg/ml), Escherichia coli ATCC 25922 (MIC=25 ¦Ìg/ml), Pseudomonas aeruginosa AB93066 (MIC=25 ¦Ìg/ml), Pseudomonas aeruginosa A092994 (MIC=50 ¦Ìg/ml), Pseudomonas aeruginosa A093052 (MIC=100 ¦Ìg/ml), Pseudomonas aeruginosa A093056 (MIC=50 ¦Ìg/ml), Pseudomonas aeruginosa A093085 (MIC=50 ¦Ìg/ml), Pseudomonas aeruginosa A093115 (MIC=100 ¦Ìg/ml)."	"[Ref.22792229]Non-hemolysis at 6.25 ¦Ìg/ml, 5% hemolysis at 12.5 ¦Ìg/ml,10% hemolysis at 25 ¦Ìg/ml 15% hemolysis at 50 ¦Ìg/ml, 40% hemolysis at 100 ¦Ìg/ml against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22792229	PLoS One. 2012;7(7):e40135. doi: 10.1371/journal.pone.0040135.	"Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z, Li W."	Antibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo.
DRAMP18559	IWRIFRRIF	9	HFU3	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22699557]Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=4 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 ¦ÌM), Pseudomonas aeruginosa 27853 (MIC=4 ¦ÌM)"	[Ref.22699557]MHC=101.4 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22699557	Amino Acids. 2012 Dec;43(6):2527-36. doi: 10.1007/s00726-012-1334-7.	"Ma QQ, Dong N, Shan AS, Lv YF, Li YZ, Chen ZH, Cheng BJ, Li ZY."	Biochemical property and membrane-peptide interactions of de novo antimicrobial peptides designed by helix-forming units.
DRAMP18560	IWRIFRRIFRIF	12	HFU4	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Has hemolytic activity.	"[Ref.22699557]Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=1 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4 ¦ÌM), Pseudomonas aeruginosa 27853 (MIC=4 ¦ÌM)"	[Ref.22699557]MHC=19.6 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22699557	Amino Acids. 2012 Dec;43(6):2527-36. doi: 10.1007/s00726-012-1334-7.	"Ma QQ, Dong N, Shan AS, Lv YF, Li YZ, Chen ZH, Cheng BJ, Li ZY."	Biochemical property and membrane-peptide interactions of de novo antimicrobial peptides designed by helix-forming units.
DRAMP18561	IWRIFRRIFRIFIRF	15	HFU5	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22699557]Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=8 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 ¦ÌM), Pseudomonas aeruginosa 27853 (MIC=16 ¦ÌM)"	[Ref.22699557]MHC=15.0 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22699557	Amino Acids. 2012 Dec;43(6):2527-36. doi: 10.1007/s00726-012-1334-7.	"Ma QQ, Dong N, Shan AS, Lv YF, Li YZ, Chen ZH, Cheng BJ, Li ZY."	Biochemical property and membrane-peptide interactions of de novo antimicrobial peptides designed by helix-forming units.
DRAMP18562	KSLVRRWRSRW	11	MAP-04-01 (Ixosin-B peptide derivative)	No entry found	Derived from the peptide Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. No hemolytic activity.	"[Ref.22578463]Gram-positive bacterium: Staphylococcus aureus (MIC90=30 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC90=30 ¦ÌM), Pseudomonas aeroginosa (MIC90=40 ¦ÌM)"	[Ref.22578463]Non-hemolysis at 100¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22578463	Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.	"Lung FD, Wang KS, Liao ZJ, Hsu SK, Song FY, Liou CC, Wu YS."	Discovery of potent antimicrobial peptide analogs of Ixosin-B.
DRAMP18563	KSLRRVWRSWR	11	MAP-04-02 (Ixosin-B peptide derivative)	No entry found	Derived from the peptide Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.No hemolytic activity.	"[Ref.22578463]Gram-positive bacterium: Staphylococcus aureus (MIC90=60 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC90=30 ¦ÌM), Pseudomonas aeroginosa (MIC90=40 ¦ÌM)"	[Ref.22578463]Non-hemolysis at 100¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22578463	Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.	"Lung FD, Wang KS, Liao ZJ, Hsu SK, Song FY, Liou CC, Wu YS."	Discovery of potent antimicrobial peptide analogs of Ixosin-B.
DRAMP18564	KWLRRVWRWWR	11	MAP-04-03 (Ixosin-B peptide derivative)	No entry found	Derived from the peptide Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Highly hemolytic activity.	"[Ref.22578463]Gram-positive bacterium: Staphylococcus aureus (MIC90=2.5 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC90=15 ¦ÌM), Pseudomonas aeroginosa (MIC90=20 ¦ÌM)"	[Ref.22578463]100% hemolysis at 100¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22578463	Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.	"Lung FD, Wang KS, Liao ZJ, Hsu SK, Song FY, Liou CC, Wu YS."	Discovery of potent antimicrobial peptide analogs of Ixosin-B.
DRAMP18565	KRLRRVWRRWR	11	MAP-04-04 (Ixosin-B peptide derivative)	No entry found	Derived from the peptide Ixosin-B	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.22578463]Gram-positive bacterium: Staphylococcus aureus (MIC90=5 ¦ÌM);##Gram-negative bacterium: Escherichia coli (MIC90=30 ¦ÌM), Pseudomonas aeroginosa (MIC90=20 ¦ÌM)"	[Ref.22578463]3% hemolysis at 100¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22578463	Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.	"Lung FD, Wang KS, Liao ZJ, Hsu SK, Song FY, Liou CC, Wu YS."	Discovery of potent antimicrobial peptide analogs of Ixosin-B.
DRAMP18566	VNWKKSLGKSIKVVK	15	LL-IIIs-1 (lasioglossin III peptide derivative)	No entry found	Derived from the peptide lasioglossin III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=0.7 ¦ÌM), Bacillus cereus (MIC=0.8 ¦ÌM), Staphylococcus aureus  (MIC=12.5 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=4.4 ¦ÌM), Pseudomonas aeruginosa (MIC=78.7 ¦ÌM);##Fungi: Candida albicans (MIC=100 ¦ÌM)"	[Ref.22526241]LC50=31.3 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18567	VNWKKILGKSIKVSK	15	LL-IIIs-2 (lasioglossin III peptide derivative)	No entry found	Derived from the peptide lasioglossin III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=0.9 ¦ÌM), Bacillus cereus (MIC=1.2 ¦ÌM), Staphylococcus aureus  (MIC=20.3 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=8.8 ¦ÌM), Pseudomonas aeruginosa (MIC=86.7 ¦ÌM);##Fungi: Candida albicans (MIC=100 ¦ÌM)"	[Ref.22526241]LC50=69 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18568	VSWKKSLGKIIKVVK	15	LL-IIIs-3 (lasioglossin III peptide derivative)	No entry found	Derived from the peptide lasioglossin III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.4 ¦ÌM), Bacillus cereus (MIC=1.1 ¦ÌM), Staphylococcus aureus  (MIC=21.7 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=1.2 ¦ÌM), Pseudomonas aeruginosa (MIC=76.3 ¦ÌM);##Fungi: Candida albicans (MIC=93.3 ¦ÌM)"	[Ref.22526241]LC50=30 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18569	VNSKKISGKSIKVSK	15	LL-IIIs-4 (lasioglossin III peptide derivative)	No entry found	Derived from the peptide lasioglossin III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=2 ¦ÌM), Bacillus cereus (MIC=1.1 ¦ÌM), Staphylococcus aureus  (MIC=80 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=20 ¦ÌM)."	[Ref.22526241]LC50>100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18570	VNRKKILGKSIKVVK	15	LL-IIIs-5 cis (lasioglossin III peptide derivative)	No entry found	Derived from the peptide lasioglossin III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=0.9 ¦ÌM), Bacillus cereus (MIC=0.9 ¦ÌM), Staphylococcus aureus  (MIC=45 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=3.5 ¦ÌM), Pseudomonas aeruginosa (MIC=80 ¦ÌM)."	[Ref.22526241]LC50=100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18571	VNRKKILGKSIKVVK	15	LL-IIIs-5 trans (lasioglossin III peptide derivative)	No entry found	Derived from the peptide lasioglossin III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.1 ¦ÌM), Bacillus cereus (MIC=1.3 ¦ÌM), Staphylococcus aureus  (MIC=65 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=5.5 ¦ÌM), Pseudomonas aeruginosa (MIC=80 ¦ÌM)."	[Ref.22526241]LC50>100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18572	VNSKKISPKSIKVSK	15	LL-IIIs-6a (lasioglossin III peptide derivative)	No entry found	Derived from the peptide lasioglossin III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1 ¦ÌM), Bacillus cereus (MIC=1.1 ¦ÌM), Staphylococcus aureus  (MIC=93 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=7.8 ¦ÌM), Pseudomonas aeruginosa (MIC=93 ¦ÌM)."	[Ref.22526241]LC50>100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18573	VNSKKISPKSIKVSK	15	LL-IIIs-6b (lasioglossin III peptide derivative)	No entry found	Derived from the peptide lasioglossin III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=0.9 ¦ÌM), Bacillus cereus (MIC=0.8 ¦ÌM), Staphylococcus aureus  (MIC=50 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=7.8 ¦ÌM), Pseudomonas aeruginosa (MIC=63 ¦ÌM)."	[Ref.22526241]LC50=82 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18574	GFLSILKKVLPKVXAHXK	18	MEP-N (melectin peptide derivative)	No entry found	Derived from the peptide melectin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1 ¦ÌM), Bacillus cereus (MIC=0.5 ¦ÌM), Staphylococcus aureus (MIC=2.5 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=0.9 ¦ÌM), Pseudomonas aeruginosa (MIC=17.3 ¦ÌM);##Fungi: Candida albicans (MIC=15 ¦ÌM)"	[Ref.22526241]LC50=50 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18575	GFLSILKKVLPKSXAHSK	18	MEP-Ns-1 (melectin peptide derivative)	No entry found	Derived from the peptide melectin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=0.8 ¦ÌM), Bacillus cereus (MIC=1.1 ¦ÌM), Staphylococcus aureus (MIC=10.8 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2.5 ¦ÌM), Pseudomonas aeruginosa (MIC=77 ¦ÌM);##Fungi: Candida albicans (MIC=30 ¦ÌM)"	[Ref.22526241]LC50=18.1 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18576	GFLSSLKKSLPKVXAHXK	18	MEP-Ns-2 (melectin peptide derivative)	No entry found	Derived from the peptide melectin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.5 ¦ÌM), Bacillus cereus (MIC=1.2 ¦ÌM), Staphylococcus aureus  (MIC=37 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=7.8 ¦ÌM)."	[Ref.22526241]LC50=14.7 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18577	GFLSSLKKSLPKSXAHSK	18	MEP-Ns-3 (melectin peptide derivative)	No entry found	Derived from the peptide melectin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.3 ¦ÌM), Bacillus cereus (MIC=1.2 ¦ÌM) ;##Gram-negative bacteria: Escherichia coli (MIC=46.7 ¦ÌM)."	[Ref.22526241]LC50=13.9 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18578	GFRSILKKVSPKVXAHXK	18	MEP-Ns-4 cis (melectin peptide derivative)	No entry found	Derived from the peptide melectin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.5 ¦ÌM), Bacillus cereus (MIC=1.3 ¦ÌM), Staphylococcus aureus (MIC=37 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=8.1 ¦ÌM)."	[Ref.22526241]LC50=11 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18579	GFRSILKKVSPKVXAHXK	18	MEP-Ns-4 trans (melectin peptide derivative)	No entry found	Derived from the peptide melectin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=2 ¦ÌM), Bacillus cereus (MIC=1.7 ¦ÌM), Staphylococcus aureus (MIC=63 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=16.3 ¦ÌM)."	[Ref.22526241]LC50=20 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18580	GFLSSLKKSLGKSXAHSK	18	MEP-Ns-5 (melectin peptide derivative)	No entry found	Derived from the peptide melectin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.5 ¦ÌM), Bacillus cereus (MIC=1.2 ¦ÌM), Staphylococcus aureus (MIC=57 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=5.6 ¦ÌM)."	[Ref.22526241]LC50=29 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18581	GFLSSLKKSLAKSXAHSK	18	MEP-Ns-6 (melectin peptide derivative)	No entry found	Derived from the peptide melectin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=1.5 ¦ÌM), Bacillus cereus (MIC=1.2 ¦ÌM), Staphylococcus aureus (MIC=43 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=5.6 ¦ÌM)."	[Ref.22526241]LC50=39.5 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58.	"Chapuis H, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Monincov¨¢ L, Bud¨§?¨ªnsk? M, ?e?ovsk? V."	Effect of hydrocarbon stapling on the properties of 
DRAMP18582	KWFRVYRGIYRRR	13	CDT (Tachyplesin-1 peptide derivative)	No entry found	Derived from the peptide Tachyplesin-1 	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Beta strand	All of the four Cys residues were deleted from the primary structure of AMP.	None	Function: The MIC values of CDT were even found to be lower against Escherichia coli and Listeria monocytogenes in comparison to the native TP-1 peptide. No hemolytic activity.	No MICs found in DRAMP database	[Ref.22464970]Non-hemolysis at 200 ¦Ìg/mL against Not found (The literature does not mention).	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22464970	Biochim Biophys Acta. 2012 Jul;1818(7):1613-24.	"Saravanan R, Mohanram H, Joshi M, Domadia PN, Torres J, Ruedl C, Bhattacharjya S."	"Structure, activity and interactions of the cysteine deleted analog of tachyplesin-1 with lipopolysaccharide micelle: Mechanistic insights into outer-membrane permeabilization and endotoxin neutralization."
DRAMP18583	KWCFCVCYRGICYCRCRG	18	"Tricystine cyclic cystine TP (ccTP, Tachyplesin-1 peptide derivative)"	No entry found	Derived from the peptide Tachyplesin-1	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Beta tile	"Although there is insufficient information to deconvolute these CD spectra of these two-b-strand cyclic cystine-knot structures due to the various contributions by ¦Â-turns, aromatic residues, disulfides and b-sheet structures, it is reasonable to conclude that all cyclic tachyplesins 2¨C6 as well as RTD display ordered structures in methanol."	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria.Antifungal activity agaist Candida albicans, Candida kefyr, Candida tropicalis"	"[Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.0 ¦ÌM in low-salt; MIC=0.8 ¦ÌM in high-salt), Micrococcus luteus (MIC=0.5 ¦ÌM in low-salt; MIC=0.4 ¦ÌM in high-salt), Enterococcus faecalis (MIC=1.0 ¦ÌM in low-salt; MIC=0.9 ¦ÌM in high-salt);##Gram-negative bacteria: Escherichia coli (MIC=3.0 ¦ÌM in low-salt; MIC=6.9 ¦ÌM in high-salt), Pseudomonas aeruginosa (MIC=5.0 ¦ÌM in low-salt; MIC=5.2 ¦ÌM in high-salt), Primula vulgaris (MIC=6.0 ¦ÌM in low-salt; MIC=14.4 ¦ÌM in high-salt), Klebsiella oxytoca (MIC=2.1 ¦ÌM in low-salt; MIC=7.8 ¦ÌM in high-salt);##Fungi: Candida albicans (MIC=5.1 ¦ÌM in low-salt; MIC=17.2 ¦ÌM in high-salt), Candida kefyr (MIC=3.9 ¦ÌM in low-salt; MIC=4.1 ¦ÌM in high-salt), Candida tropicalis (MIC=5.2 ¦ÌM in low-salt; MIC=1.1 ¦ÌM in high-salt)."	[Ref.10673369] EC25=3800 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12."	L	No cytotoxicity information found	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"Tam JP, Lu YA, Yang JL."	Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework.
DRAMP18584	KWCFCVCYRGICRCRCRG	18	[Arg13]ccTP (ccTP peptide derivative)	No entry found	Derived from the peptide ccTP	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.3 ¦ÌM in low-salt; MIC=0.9 ¦ÌM in high-salt), Micrococcus luteus (MIC=0.5 ¦ÌM in low-salt; MIC=0.5 ¦ÌM in high-salt), Enterococcus faecalis (MIC=1.9 ¦ÌM in low-salt; MIC=1.3 ¦ÌM in high-salt);##Gram-negative bacteria: Escherichia coli (MIC=10.4 ¦ÌM in low-salt; MIC=0.9 ¦ÌM in high-salt), Pseudomonas aeruginosa (MIC=6.2 ¦ÌM in low-salt; MIC=10.4 ¦ÌM in high-salt), Primula vulgaris (MIC=16.4 ¦ÌM in low-salt; MIC=28.9 ¦ÌM in high-salt), Klebsiella oxytoca (MIC=4.0 ¦ÌM in low-salt; MIC=7.6 ¦ÌM in high-salt);##Fungi: Candida albicans (MIC=24.2 ¦ÌM in low-salt; MIC=30.2 ¦ÌM in high-salt), Candida kefyr (MIC=1.1 ¦ÌM in low-salt; MIC=4.3 ¦ÌM in high-salt), Candida tropicalis (MIC=12.4 ¦ÌM in low-salt; MIC=3.9 ¦ÌM in high-salt)."	[Ref.10673369] EC25=590 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12."	L	No cytotoxicity information found	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"Tam JP, Lu YA, Yang JL."	Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework.
DRAMP18585	KWCRCVCRRGICYCRCRG	18	"[Arg4,8]ccTP (ccTP peptide derivative)"	No entry found	Derived from the peptide ccTP	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Beta tile	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.3 ¦ÌM in low-salt; MIC=0.3 ¦ÌM in high-salt), Micrococcus luteus (MIC=0.5 ¦ÌM in low-salt; MIC=0.7 ¦ÌM in high-salt), Enterococcus faecalis (MIC=1.0 ¦ÌM in low-salt; MIC=1.2 ¦ÌM in high-salt);##Gram-negative bacteria: Escherichia coli (MIC=9.8 ¦ÌM in low-salt; MIC=2.0 ¦ÌM in high-salt), Pseudomonas aeruginosa (MIC=8.0 ¦ÌM in low-salt; MIC=5.3 ¦ÌM in high-salt), Primula vulgaris (MIC=26.7 ¦ÌM in low-salt; MIC=56.2 ¦ÌM in high-salt), Klebsiella oxytoca (MIC=6.1 ¦ÌM in low-salt; MIC=7.8 ¦ÌM in high-salt);##Fungi: Candida albicans (MIC=6.4 ¦ÌM in low-salt; MIC=11.2 ¦ÌM in high-salt), Candida kefyr (MIC=1.1 ¦ÌM in low-salt; MIC=1.9 ¦ÌM in high-salt), Candida tropicalis (MIC=2.8 ¦ÌM in low-salt; MIC=4.2 ¦ÌM in high-salt)."	[Ref.10673369] EC25=910 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12."	L	No cytotoxicity information found	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"Tam JP, Lu YA, Yang JL."	Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework.
DRAMP18586	KWCRCVCRRGICRCRCRG	18	"[Arg4,8,13]ccTP (ccTP peptide derivative)"	No entry found	Derived from the peptide ccTP	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.7 ¦ÌM in low-salt; MIC=1.3 ¦ÌM in high-salt), Micrococcus luteus (MIC=0.5 ¦ÌM in low-salt; MIC=0.8 ¦ÌM in high-salt), Enterococcus faecalis (MIC=0.7 ¦ÌM in low-salt; MIC=0.5 ¦ÌM in high-salt);##Gram-negative bacteria: Escherichia coli (MIC=5.5 ¦ÌM in low-salt; MIC=1.2 ¦ÌM in high-salt), Pseudomonas aeruginosa (MIC=3.9 ¦ÌM in low-salt; MIC=4.7 ¦ÌM in high-salt), Primula vulgaris (MIC=16.8 ¦ÌM in low-salt; MIC=55.6 ¦ÌM in high-salt), Klebsiella oxytoca (MIC=2.4 ¦ÌM in low-salt; MIC=5.4 ¦ÌM in high-salt);##Fungi: Candida albicans (MIC=7.1 ¦ÌM in low-salt; MIC=5.1 ¦ÌM in high-salt), Candida kefyr (MIC=4.2 ¦ÌM in low-salt; MIC=0.7 ¦ÌM in high-salt), Candida tropicalis (MIC=1.9 ¦ÌM in low-salt; MIC=4.8 ¦ÌM in high-salt)."	[Ref.10673369] EC25=920 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12."	L	No cytotoxicity information found	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"Tam JP, Lu YA, Yang JL."	Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework.
DRAMP18587	KWCRCVCRRGICRCRCRK	18	"[Arg4,8,13][Lys18]ccTP (ccTP peptide derivative)"	No entry found	Derived from the peptide ccTP	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.7 ¦ÌM in low-salt; MIC=0.7 ¦ÌM in high-salt), Micrococcus luteus (MIC=0.3 ¦ÌM in low-salt; MIC=0.4 ¦ÌM in high-salt), Enterococcus faecalis (MIC=1.4 ¦ÌM in low-salt; MIC=1.2 ¦ÌM in high-salt);##Gram-negative bacteria: Escherichia coli (MIC=6.1 ¦ÌM in low-salt; MIC=1.2 ¦ÌM in high-salt), Pseudomonas aeruginosa (MIC=2.0 ¦ÌM in low-salt; MIC=4.7 ¦ÌM in high-salt), Primula vulgaris (MIC=17.0 ¦ÌM in low-salt; MIC=39.8 ¦ÌM in high-salt), Klebsiella oxytoca (MIC=4.1 ¦ÌM in low-salt; MIC=4.1 ¦ÌM in high-salt);##Fungi: Candida albicans (MIC=10.5 ¦ÌM in low-salt; MIC=5.2 ¦ÌM in high-salt), Candida kefyr (MIC=1.1 ¦ÌM in low-salt; MIC=0.7 ¦ÌM in high-salt), Candida tropicalis (MIC=2.3 ¦ÌM in low-salt; MIC=1.9 ¦ÌM in high-salt)."	[Ref.10673369] EC25=3900 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12."	L	No cytotoxicity information found	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"Tam JP, Lu YA, Yang JL."	Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework.
DRAMP18588	GFCRCLCRRGVCRCICTK	18	RTD	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.1 ¦ÌM in low-salt; MIC=0.9 ¦ÌM in high-salt), Micrococcus luteus (MIC=0.5 ¦ÌM in low-salt; MIC=0.4 ¦ÌM in high-salt), Enterococcus faecalis (MIC=1.2 ¦ÌM in low-salt; MIC=1.2 ¦ÌM in high-salt);##Gram-negative bacteria: Escherichia coli (MIC=2.0 ¦ÌM in low-salt; MIC=28.4 ¦ÌM in high-salt), Pseudomonas aeruginosa (MIC=2.0 ¦ÌM in low-salt; MIC=5.2 ¦ÌM in high-salt), Primula vulgaris (MIC=10.2 ¦ÌM in low-salt; MIC=50.4 ¦ÌM in high-salt), Klebsiella oxytoca (MIC=2.0 ¦ÌM in low-salt; MIC=12.8 ¦ÌM in high-salt);##Fungi: Candida albicans (MIC=4.0 ¦ÌM in low-salt; MIC=5.2 ¦ÌM in high-salt), Candida kefyr (MIC=1.8 ¦ÌM in low-salt; MIC=1.2 ¦ÌM in high-salt), Candida tropicalis (MIC=2.8 ¦ÌM in low-salt; MIC=1.0 ¦ÌM in high-salt)."	[Ref.10673369]EC25=2350 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"Tam JP, Lu YA, Yang JL."	Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework.
DRAMP18589	GWLDVAKKIGKAAFNVAKNFLFNKAVNFAAKGIKKAVDLWG	42	DSE (Ctx-Ha peptide derivative)	No entry found	Derived from the peptide Ctx-Ha	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.Has hemolytic activity."	[Ref.22391524]Gram-positive bacterium: Staphylococcus aureus (MIC=8.9 ¦Ìmol/L; MMC=13.3 ¦Ìmol/L);##Gram-negative bacterium: Escherichia coli (MIC=3.3 ¦Ìmol/L; MMC=13.3 ¦Ìmol/L);##Fungi: Candida albicans (MIC=53.3 ¦Ìmol/L; MMC=53.3 ¦Ìmol/L)	[Ref.22391524]HC50=0.6¡À0.1 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22391524	Antimicrob Agents Chemother. 2012 Jun;56(6):3004-10.	"Lorenz¨®n EN, Cespedes GF, Vicente EF, Nogueira LG, Bauab TM, Castro MS, Cilli EM."	Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.
DRAMP18590	GWLDVAKKIGKAAFNVAKNFL-spacer-LFNKAVNFAAKGIKKAVDLWG	42	DEP (Ctx-Ha peptide derivative)	No entry found	Derived from the peptide Ctx-Ha	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	[Ref.22391524]Gram-positive bacterium: Staphylococcus aureus (MIC=3.2 ¦Ìmol/L; MMC=12.9 ¦Ìmol/L);##Gram-negative bacterium: Escherichia coli (MIC=1.6 ¦Ìmol/L; MMC=3.2 ¦Ìmol/L);##Fungi: Candida albicans (MIC=51.7 ¦Ìmol/L; MMC=51.7 ¦Ìmol/L)	[Ref.22391524]HC50=0.7¡À0.1 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22391524	Antimicrob Agents Chemother. 2012 Jun;56(6):3004-10.	"Lorenz¨®n EN, Cespedes GF, Vicente EF, Nogueira LG, Bauab TM, Castro MS, Cilli EM."	Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.
DRAMP18591	GWLDVAKKIGKAAFNVAKNFL-spacer-LFNKAVNFAAKGIKKAVDLWG	42	DEA (Ctx-Ha peptide derivative)	No entry found	Derived from the peptide Ctx-Ha	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	[Ref.22391524]Gram-positive bacterium: Staphylococcus aureus (MIC=12.9 ¦Ìmol/L; MMC=25.9 ¦Ìmol/L);##Gram-negative bacterium: Escherichia coli (MIC=6.5 ¦Ìmol/L; MMC=12.9 ¦Ìmol/L);##Fungi: Candida albicans (MIC=100 ¦Ìmol/L; MMC<100 ¦Ìmol/L)	[Ref.22391524]HC50=0.8¡À0.1 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22391524	Antimicrob Agents Chemother. 2012 Jun;56(6):3004-10.	"Lorenz¨®n EN, Cespedes GF, Vicente EF, Nogueira LG, Bauab TM, Castro MS, Cilli EM."	Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.
DRAMP18592	GWLDVAKKIGKAAFNVAKNFI	21	Ctx(Ile21)-Ha (Ctx-Ha peptide derivative)	No entry found	Derived from the peptide Ctx-Ha	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.22519531]Gram-positive bacterium: Staphylococcus aureus (MIC=1 ¦Ìmol/L);##Gram-negative bacteria: Escherichia coli (MIC=4 ¦Ìmol/L), Pseudomonas aeruginosa (MIC=8 ¦Ìmol/L);##Fungi: Candida albicans (MIC=8 ¦Ìmol/L), Candida krusei (MIC=8 ¦Ìmol/L), Candida parapsilosis (MIC=4 ¦Ìmol/L), Cryptococcus neoformans (MIC=8 ¦Ìmol/L)"	[Ref.22519531]HC50=26 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22519531	Protein Pept Lett. 2012 Jun 1;19(6):596-603.	"Cespedes GF, Lorenz¨®n EN, Vicente EF, Mendes-Giannini MJ, Fontes W, Castro MS, Cilli EM."	Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus.
DRAMP18593	GWLDVAKKIGKAAFNVAKNFI	21	Ctx(Ile21)-Ha-VD16 (Ctx-Ha peptide derivative)	No entry found	Derived from the peptide Ctx-Ha	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. D-Valine to replace L-Valine at the position 16 on the peptide Ctx(Ile21)-Ha. Has hemolytic activity."	"[Ref.22519531]Gram-positive bacterium: Staphylococcus aureus (MIC=2 ¦Ìmol/L);##Gram-negative bacteria: Escherichia coli (MIC=4 ¦Ìmol/L), Pseudomonas aeruginosa (MIC=16 ¦Ìmol/L);##Fungi: Candida albicans (MIC=31 ¦Ìmol/L), Candida krusei (MIC=16 ¦Ìmol/L), Candida parapsilosis (MIC=31 ¦Ìmol/L), Cryptococcus neoformans (MIC=31 ¦Ìmol/L)"	[Ref.22519531]HC50=18.7 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22519531	Protein Pept Lett. 2012 Jun 1;19(6):596-603.	"Cespedes GF, Lorenz¨®n EN, Vicente EF, Mendes-Giannini MJ, Fontes W, Castro MS, Cilli EM."	Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus.
DRAMP18594	GWLDVAKKIGKAAFNVAKNFI	21	"Ctx(Ile21)-Ha-VD5,16 (Ctx-Ha peptide derivative)"	No entry found	Derived from the peptide Ctx-Ha	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. D-Valine to replace L-Valine at the position 5 and 16 on the peptide Ctx(Ile21)-Ha.Has hemolytic activity."	"[Ref.22519531]Gram-positive bacterium: Staphylococcus aureus (MIC=64 ¦Ìmol/L);##Gram-negative bacteria: Escherichia coli (MIC=16 ¦Ìmol/L), Pseudomonas aeruginosa (MIC=128 ¦Ìmol/L);##Fungi: Candida albicans (MIC=16 ¦Ìmol/L), Candida krusei (MIC=16 ¦Ìmol/L), Candida parapsilosis (MIC=31 ¦Ìmol/L), Cryptococcus neoformans (MIC=31 ¦Ìmol/L)"	[Ref.22519531]HC50=43.1 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22519531	Protein Pept Lett. 2012 Jun 1;19(6):596-603.	"Cespedes GF, Lorenz¨®n EN, Vicente EF, Mendes-Giannini MJ, Fontes W, Castro MS, Cilli EM."	Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus.
DRAMP18595	GWLDVAKKKGKAAFNVAKNFI	21	Ctx(Ile21)-Ha-I9K (Ctx-Ha peptide derivative)	No entry found	Derived from the peptide Ctx-Ha	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. L-Lysine to replace L-Isoleucine at the position 9 on the peptide Ctx(Ile21)-Ha.Has hemolytic activity."	"[Ref.22519531]Gram-negative bacteria: Escherichia coli (MIC=8 ¦Ìmol/L), Pseudomonas aeruginosa (MIC=32 ¦Ìmol/L);##Fungi: Candida albicans (MIC=16 ¦Ìmol/L), Candida krusei (MIC=31 ¦Ìmol/L), Candida parapsilosis (MIC=31 ¦Ìmol/L), Cryptococcus neoformans (MIC=31 ¦Ìmol/L)"	[Ref.22519531]HC50=24.9 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22519531	Protein Pept Lett. 2012 Jun 1;19(6):596-603.	"Cespedes GF, Lorenz¨®n EN, Vicente EF, Mendes-Giannini MJ, Fontes W, Castro MS, Cilli EM."	Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus.
DRAMP18596	NVWKKVLGKIIKVAK	15	LL-I/1 (Lasioglossin LL-I peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-I	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity. 	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=1.3 ¦ÌM), Staphylococcus aureus (MIC=71.6 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2.5 ¦ÌM), Pseudomonas aeruginosa (MIC=22.7 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2102.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18597	VNWKKVLAKIIKVAK	15	LL-I/2 (Lasioglossin LL-I peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-I	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.6 ¦ÌM), Staphylococcus aureus (MIC=7.2 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=0.7 ¦ÌM), Pseudomonas aeruginosa (MIC=26.9 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2103.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18598	VNWKKVLKKIIKVAK	15	LL-I/3 (Lasioglossin LL-I peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-I	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.7 ¦ÌM), Staphylococcus aureus (MIC=15.6 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=0.7 ¦ÌM), Pseudomonas aeruginosa (MIC=19.0 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2104.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18599	VNWKKVLPKIIKVAK	15	LL-I/4 (Lasioglossin LL-I peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-I	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.9 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=5.0 ¦ÌM), Pseudomonas aeruginosa (MIC=100 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2105.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18600	NVWKKILGKIIKVAK	15	LL-II/1 (Lasioglossin LL-II peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-II	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.7 ¦ÌM), Staphylococcus aureus (MIC=19.7 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=1.1 ¦ÌM), Pseudomonas aeruginosa (MIC=23.3 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2106.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18601	VNWKKILAKIIKVAK	15	LL-II/2 (Lasioglossin LL-II peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-II	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.Has hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.7 ¦ÌM), Staphylococcus aureus (MIC=4.3 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=0.7 ¦ÌM), Pseudomonas aeruginosa (MIC=22.5 ¦ÌM)."	[Ref.19591185]LC50=66.5 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2107.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18602	VNWKKILKKIIKVAK	15	LL-II/3 (Lasioglossin LL-II peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-II	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.7 ¦ÌM), Staphylococcus aureus (MIC=15.6 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=0.7 ¦ÌM), Pseudomonas aeruginosa (MIC=26.1 ¦ÌM)."	[Ref.19591185]LC50=88.2 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2108.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18603	VNWKKILPKIIKVAK	15	LL-II/4 (Lasioglossin LL-II peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-II	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.7 ¦ÌM), Staphylococcus aureus (MIC=80 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2.5 ¦ÌM), Pseudomonas aeruginosa (MIC=100 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2109.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18604	NVWKKILGKIIKVVK	15	LL-III/1 (Lasioglossin LL-III peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.7 ¦ÌM), Staphylococcus aureus (MIC=9.0 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=1.4 ¦ÌM), Pseudomonas aeruginosa (MIC=23.1 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2110.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18605	VNWKKILAKIIKVVK	15	LL-III/2 (Lasioglossin LL-III peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.6 ¦ÌM), Staphylococcus aureus (MIC=2.2 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=1.4 ¦ÌM), Pseudomonas aeruginosa (MIC=27.1 ¦ÌM)."	[Ref.19591185]LC50=55.1 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2111.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18606	VNWKKILKKIIKVVK	15	LL-III/3 (Lasioglossin LL-III peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.Has hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.7 ¦ÌM), Staphylococcus aureus (MIC=9.6 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=0.7 ¦ÌM), Pseudomonas aeruginosa (MIC=26.1 ¦ÌM)."	[Ref.19591185]LC50=72.2 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2112.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18607	VNWKKILPKIIKVVK	15	LL-III/4 (Lasioglossin LL-III peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.8 ¦ÌM), Staphylococcus aureus (MIC=32.5 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=1.2 ¦ÌM), Pseudomonas aeruginosa (MIC=100 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2113.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18608	VNWKKILGKIIKVVK	15	LL-III/5 (Lasioglossin LL-III peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-III	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.Weak hemolytic activity.
PTM: C-terminal hydroxyl modification"	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=1.2 ¦ÌM), Staphylococcus aureus (MIC=40 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=3.5 ¦ÌM), Pseudomonas aeruginosa (MIC=40 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2114.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18609	VNWKKILGKIIKVVK	15	LL-¢ó/6 (Lasioglossin LL-¢ó peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-¢ó	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
PTM: C-terminal methoxy modification"	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=0.5 ¦ÌM), Staphylococcus aureus (MIC=2.1 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=1.0 ¦ÌM), Pseudomonas aeruginosa (MIC=22.5 ¦ÌM)."	[Ref.19591185]LC50=79.3 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2115.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18610	VNWKKILGKI	10	LL-¢ó/7 (Lasioglossin LL-¢ó peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-¢ó	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=4.7 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=23.3 ¦ÌM), Pseudomonas aeruginosa (MIC=75 ¦ÌM)."	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2116.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18611	ILGKIIKVVK	10	LL-¢ó/8 (Lasioglossin LL-¢ó peptide derivative)	No entry found	Derived from the peptide Lasioglossin LL-¢ó 	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.	[Ref.19591185]Gram-positive bacteria: Bacillus subtilis (MIC=40 ¦ÌM).	[Ref.19591185]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19591185	Chembiochem. 2009 Aug 17;10(12):2089-2117.	"Cerovsk? V, Budes¨ªnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov¨¢ J, Borovickov¨¢ L, Fuc¨ªk V, Bedn¨¢rov¨¢ L, Votruba I, Straka J."	Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae.
DRAMP18613	VRRFGWWWGFLRR	13	TPG (Tritrpticin peptide derivative)	No entry found	Derived from the peptide Tritrpticin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.12207877]Gram-positive bacteria: Bacillus subtilis (MIC=16 ¦Ìg/ml), Staphylococcus aureus (MIC=16 ¦Ìg/ml), Staphylococcus epidermidis (MIC=8 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli (MIC=32 ¦Ìg/ml), Salmonella typhimurium (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa (MIC=64 ¦Ìg/ml);##Fungus: Candida albicans (MIC=32 ¦Ìg/ml)."	"[Ref.12207877]6% hemolysis at 25 ¦Ìg/ml, 15% hemolysis at 50 ¦Ìg/ml, 25% hemolysis at 100 ¦Ìg/ml, 70% hemolysis at 200 ¦Ìg/ml against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12207877	Biochem Biophys Res Commun. 2002 Sep 6;296(5):1044-50.	"Yang ST, Yub Shin SY, Kim YC, Kim Y, Hahm KS, Kim JI."	"Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide."
DRAMP18627	KLKKLLKKWLKLLKKLLK	18	D4-K9L8W (D-amino acid substitution of K9L8W)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. D-Leucine replace L-Leucine at the position 12 and 16 on the peptide K9L8W, D-Lysine replace L-Lysine at the position 4 and 8 on the peptide K9L8W. Weak hemolytic activity."	"[Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=1 ¦ÌM), Staphylococcus epidermidis (MIC=2 ¦ÌM), Staphylococcus aureus (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2 ¦ÌM), Pseudomonas aeruginosa (MIC=2 ¦ÌM), Salmonella typhimurium (MIC=2 ¦ÌM)."	[Ref.20363271]HC50>800 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20363271	Peptides. 2010 Jul;31(7):1251-61.	"Wang P, Nan YH, Yang ST, Kang SW, Kim Y, Park IS, Hahm KS, Shin SY."	Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.
DRAMP18507	FSGGNCRGFRRRCFCTK	17	"SolyC (Plant defensin; tomato, plants)"	No entry found	Belongs to the tomato defensin family	Not found	Tomato	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Beta sheet	Not found	None	"Function: Antibacterial activity against a panel of human pathogens, including H.pylori, and displays anti-inflammatory activity in vitro. Weak hemolytic activity."	"[Ref.23124812]Gram-positive bacteria: Staphylococcus aureus A170 (MIC=40 ¦Ìg/mL), Staphylococcus epidermidis (MIC=40 ¦Ìg/mL), Listeria monocytogenes (MIC=40 ¦Ìg/mL);##Gram-negative bacteria: Salmonella enterica serovar Paratyphi (MIC=15 ¦Ìg/mL), Escherichia coli (MIC=15 ¦Ìg/mL), Helicobacter pylori VB1 (MIC=15 ¦Ìg/mL), Helicobacter pylori VB2 (MIC=10 ¦Ìg/mL), Helicobacter pylori VB3 (MIC=15 ¦Ìg/mL), Helicobacter pylori VB4 (MIC=12 ¦Ìg/mL), Helicobacter pylori VB5 (MIC=15 ¦Ìg/mL), Helicobacter pylori VB6 (MIC=10 ¦Ìg/mL), Helicobacter pylori VB7 (MIC=15 ¦Ìg/mL), Helicobacter pylori VB8 (MIC=10 ¦Ìg/mL), Helicobacter pylori VB9 (MIC=10 ¦Ìg/mL), Helicobacter pylori VB10 (MIC=15 ¦Ìg/mL)."	[Ref.23124812]<5%  hemolysis at 50 ¦Ìg/mL against mouse red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23124812	J Pept Sci. 2012 Dec;18(12):755-62.	"Rigano MM, Romanelli A, Fulgione A, Nocerino N, D'Agostino N, Avitabile C, Frusciante L, Barone A, Capuano F, Capparelli R."	A novel synthetic peptide from a tomato defensin exhibits antibacterial activities against Helicobacter pylori.
DRAMP18614	VRRFAWWWAFLRR	13	TPA (Tritrpticin peptide derivative)	No entry found	Derived from the peptide Tritrpticin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.12207877]Gram-positive bacteria: Bacillus subtilis (MIC=16 ¦Ìg/ml), Staphylococcus aureus (MIC=32 ¦Ìg/ml), Staphylococcus epidermidis (MIC=16 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli (MIC=32 ¦Ìg/ml), Salmonella typhimurium (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa (MIC=64 ¦Ìg/ml);##Fungus: Candida albicans (MIC=32 ¦Ìg/ml)."	"[Ref.12207877]18% hemolysis at 25 ¦Ìg/ml, 30% hemolysis at 50 ¦Ìg/ml, 62% hemolysis at 100 ¦Ìg/ml, 95% hemolysis at 200 ¦Ìg/ml against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12207877	Biochem Biophys Res Commun. 2002 Sep 6;296(5):1044-50.	"Yang ST, Yub Shin SY, Kim YC, Kim Y, Hahm KS, Kim JI."	"Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide."
DRAMP18615	VRRFPFFFPFLRR	13	TWF (Tritrpticin peptide derivative)	No entry found	Derived from the peptide Tritrpticin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. No hemolytic activity."	"[Ref.12207877]Gram-positive bacteria: Bacillus subtilis (MIC=8 ¦Ìg/ml), Staphylococcus aureus (MIC=16 ¦Ìg/ml), Staphylococcus epidermidis (MIC=8 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli (MIC=8 ¦Ìg/ml), Salmonella typhimurium (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa (MIC=16 ¦Ìg/ml);##Fungus: Candida albicans (MIC=16 ¦Ìg/ml)."	[Ref.12207877]Non-hemolysis at 200 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12207877	Biochem Biophys Res Commun. 2002 Sep 6;296(5):1044-50.	"Yang ST, Yub Shin SY, Kim YC, Kim Y, Hahm KS, Kim JI."	"Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide."
DRAMP18616	RGLRRLGRKIAHGVKKYGPTVKRIKRKA	28	"[K22,25,27]-SMAP-29 (SMAP-29 peptide derivative)"	No entry found	Derived from the peptide SMAP-29	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. No hemolytic activity."	"[Ref.11467858]Gram-positive bacteria: [No NaCl]: Bacillus subtilis (MIC=6.0 ¦ÌM), Staphylococcus aureus (MIC=2.0 ¦ÌM), Micrococcus luteus (MIC=2.0 ¦ÌM), Staphylococcus epidermidis (MIC=1.0 ¦ÌM);##[100 mM NaCl]: Bacillus subtilis (MIC=4.0 ¦ÌM), Staphylococcus aureus (MIC=1.0 ¦ÌM), Micrococcus luteus (MIC=1.0 ¦ÌM), Staphylococcus epidermidis (MIC=1.0 ¦ÌM).##Gram-negative bacteria: [No NaCl]: Escherichia coli (MIC=6.0 ¦ÌM), Salmonella typhimurium (MIC=2.0 ¦ÌM), Pseudomonas aeruginosa (MIC=12.0 ¦ÌM);[100 mM NaCl]: Escherichia coli (MIC=4.0 ¦ÌM), Salmonella typhimurium (MIC=1.0 ¦ÌM), Pseudomonas aeruginosa (MIC=4.0 ¦ÌM).##Fungi: [No NaCl]: Candida albicans (MIC=2.0 ¦ÌM);[100 mM NaCl]: Candida albicans (MIC=16.0 ¦ÌM)."	[Ref.11467858]Non-hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11467858	Biochem Biophys Res Commun. 2001 Jul 27;285(4):1046-51.	"Shin SY, Park EJ, Yang ST, Jung HJ, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide."
DRAMP18617	RGLRRLGRKIAHGVKKYGATVLRIIRIA	28	[A19]-SMAP-29 (SMAP-29 peptide derivative)	No entry found	Derived from the peptide SMAP-29	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.11467858]Gram-positive bacteria: [No NaCl]: Bacillus subtilis (MIC=4.0 ¦ÌM), Staphylococcus aureus (MIC=2.0 ¦ÌM), Micrococcus luteus (MIC=2.0 ¦ÌM), Staphylococcus epidermidis (MIC=2.0 ¦ÌM);##[100 mM NaCl]: Bacillus subtilis (MIC=2.0 ¦ÌM), Staphylococcus aureus (MIC=1.0 ¦ÌM), Micrococcus luteus (MIC=2.0 ¦ÌM), Staphylococcus epidermidis (MIC=1.0 ¦ÌM).##Gram-negative bacteria: [No NaCl]: Escherichia coli (MIC=4.0 ¦ÌM), Salmonella typhimurium (MIC=2.0 ¦ÌM), Pseudomonas aeruginosa (MIC=16.0 ¦ÌM);[100 mM NaCl]: Escherichia coli (MIC=1.0 ¦ÌM), Salmonella typhimurium (MIC=1.0 ¦ÌM), Pseudomonas aeruginosa (MIC=4.0 ¦ÌM).##Fungi: [No NaCl]: Candida albicans (MIC=2.0 ¦ÌM);[100 mM NaCl]: Candida albicans (MIC=16.0 ¦ÌM)."	"[Ref.11467858]7% hemolysis at 12.5 ¦ÌM, 13% hemolysis at 25 ¦Ìg/ml, 28% hemolysis at 50 ¦Ìg/ml, 50.4% hemolysis at 100 ¦Ìg/ml against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11467858	Biochem Biophys Res Commun. 2001 Jul 27;285(4):1046-51.	"Shin SY, Park EJ, Yang ST, Jung HJ, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide."
DRAMP18618	RGLRRLGRKIAHGVKKY	17	SMAP-29(1-17) (SMAP-29 peptide derivative)	No entry found	Derived from the peptide SMAP-29	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. No hemolytic activity."	"[Ref.11467858]Gram-positive bacteria: [No NaCl]: Bacillus subtilis (MIC=8.0 ¦ÌM), Staphylococcus aureus (MIC=2.0 ¦ÌM), Micrococcus luteus (MIC=2.0 ¦ÌM), Staphylococcus epidermidis (MIC=1.0 ¦ÌM);##[100 mM NaCl]: Bacillus subtilis (MIC=16.0 ¦ÌM), Staphylococcus aureus (MIC=4.0 ¦ÌM), Micrococcus luteus (MIC=4.0 ¦ÌM), Staphylococcus epidermidis (MIC=2.0 ¦ÌM).##Gram-negative bacteria: [No NaCl]: Escherichia coli (MIC=8.0 ¦ÌM), Salmonella typhimurium (MIC=2.0 ¦ÌM), Pseudomonas aeruginosa (MIC=8.0 ¦ÌM);[100 mM NaCl]: Escherichia coli (MIC=16.0 ¦ÌM), Salmonella typhimurium (MIC=8.0 ¦ÌM), Pseudomonas aeruginosa (MIC=16.0 ¦ÌM).##Fungi: [No NaCl]: Candida albicans (MIC=8.0 ¦ÌM);[100 mM NaCl]: Candida albicans (MIC=16.0 ¦ÌM)."	[Ref.11467858]Non-hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11467858	Biochem Biophys Res Commun. 2001 Jul 27;285(4):1046-51.	"Shin SY, Park EJ, Yang ST, Jung HJ, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide."
DRAMP18619	RKLRRLKRKIAHKVKKY	17	"[K2,7,13]-SMAP-29(1-17) (SMAP-29 peptide derivative)"	No entry found	Derived from the peptide SMAP-29	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. No hemolytic activity."	"[Ref.11467858]Gram-positive bacteria: [No NaCl]: Bacillus subtilis (MIC=4.0 ¦ÌM), Staphylococcus aureus (MIC=2.0 ¦ÌM), Micrococcus luteus (MIC=2.0 ¦ÌM), Staphylococcus epidermidis (MIC=1.0 ¦ÌM);[100 mM NaCl]: Bacillus subtilis (MIC=4.0 ¦ÌM), Staphylococcus aureus (MIC=2.0 ¦ÌM), Micrococcus luteus (MIC=1.0 ¦ÌM), Staphylococcus epidermidis (MIC=1.0 ¦ÌM).##Gram-negative bacteria: [No NaCl]: Escherichia coli (MIC=3.0 ¦ÌM), Salmonella typhimurium (MIC=2.0 ¦ÌM), Pseudomonas aeruginosa (MIC=6.0 ¦ÌM);[100 mM NaCl]: Escherichia coli (MIC=6.0 ¦ÌM), Salmonella typhimurium (MIC=4.0 ¦ÌM), Pseudomonas aeruginosa (MIC=3.0 ¦ÌM).##Fungi: [No NaCl]: Candida albicans (MIC=8.0 ¦ÌM);[100 mM NaCl]: Candida albicans (MIC=8.0 ¦ÌM)."	[Ref.11467858]Non-hemolysis at 100 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11467858	Biochem Biophys Res Commun. 2001 Jul 27;285(4):1046-51.	"Shin SY, Park EJ, Yang ST, Jung HJ, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI."	"Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide."
DRAMP18620	KKTWWKTWWTKWSQPKKKRKV	21	Pep-1-K (Pep-1 peptide derivative)	No entry found	Derived from the peptide Pep-1	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria. No hemolytic activity.	"[Ref.16945333]Gram-positive bacteria: Bacillus subtilis (KCTC 3068) (MIC=2.0 ¦ÌM), Staphylococcus aureus (KCTC 1621) (MIC=2.0 ¦ÌM), Staphylococcus epidermidis (KCTC 1917) (MIC=1.0 ¦ÌM);##Gram-negative bacteria: Escherichia coli (KCTC 1682) (MIC=2.0 ¦ÌM), Salmonella typhimurium (KCTC 1926) (MIC=1.0 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637) (MIC=2.0 ¦ÌM);##Antibiotic-resistant bacteria: MRSA 1 (CCARM 3001) (MIC=2.0 ¦ÌM), MRSA 2 (CCARM 3089) (MIC=2.0 ¦ÌM), MRSA 3 (CCARM 3543) (MIC=1.0 ¦ÌM), MDRPA 1 (CCARM 2092) (MIC=8.0 ¦ÌM), MDRPA 2 (CCARM 2095) (MIC=8.0 ¦ÌM), MDRPA 3 (CCARM 2109) (MIC=8.0 ¦ÌM)."	[Ref.16945333]Non-hemolysis at 200 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16945333	Biochem Biophys Res Commun. 2006 Oct 20;349(2):769-74.	"Zhu WL, Lan H, Park IS, Kim JI, Jin HZ, Hahm KS, Shin SY."	Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1.
DRAMP18622	FLPIVAKLLSGLLGRKKRRQRRR	23	Temporin-PEb (Temporin-PE peptide derivative)	No entry found	Derived from the peptide Temporin-PE	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.29191658]Gram-positive bacteria: Staphylococcus aureus (MIC=1.0 ¦ÌM), Methicillin-resistant Staphylococcus aureus (MIC=2.0 ¦ÌM), Enterococcus faecalis (MIC=2.0 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2.0 ¦ÌM);##Fungus: Candida albicans (MIC=1.0 ¦ÌM).##Cancer cell lines: NCI-H157 (IC50=3.464 ¦ÌM), U251MG (IC50=3.087 ¦ÌM), PC-3 (IC50=3.051 ¦ÌM), MDA-MB-435s (IC50=3.483 ¦ÌM), HMEC-1 (IC50=9.976 ¦ÌM)."	[Ref.29191658]HC50=44.64 ¦ÌM against horse red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29191658	Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546.	"Sang M, Wu Q, Xi X, Ma C, Wang L, Zhou M, Burrows JF, Chen T."	"Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus."
DRAMP18623	INLKILARLAKKIL	14	"[I5,R8] Mastoparan-L ([I5,R8] MP-L;Mastoparan-L peptide derivative)"	No entry found	Derived from the peptide Mastoparan 	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal"	Synthetic	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. [Ref.27423268]Cytotoxicity against THP-1-derived macrophages, Weak hemolytic activity."	"[Ref.27423268]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=25 ¦ÌM), Streptococcus pyogenes ATCC 19615 (MIC=6.25 ¦ÌM), Listeria ivanovii Li 4pVS2 (MIC=50 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=6.25 ¦ÌM), Klebsiella pneumoniae ATCC 13883 (MIC=6.25 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=3 ¦ÌM);##Fungi: Candida albicans ATCC 90028 (MIC=12.5 ¦ÌM), Candida parapsilosis ATCC 22019 (MIC=25 ¦ÌM)."	[Ref.27423268]LC50>200 ¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27423268	Biochim Biophys Acta. 2016 Nov;1858(11):2699-2708.	"Irazazabal LN, Porto WF, Ribeiro SM, Casale S, Humblot V, Ladram A, Franco OL."	Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan.
DRAMP18624	KLKKLLKKWLKLLKKLLK	18	K9L8W	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Has hemolytic activity.	"[Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=4 ¦ÌM), Staphylococcus epidermidis (MIC=8 ¦ÌM), Staphylococcus aureus (MIC=8 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=8 ¦ÌM), Pseudomonas aeruginosa (MIC=8 ¦ÌM), Salmonella typhimurium (MIC=4 ¦ÌM)."	[Ref.20363271]HC50=14 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20363271	Peptides. 2010 Jul;31(7):1251-61.	"Wang P, Nan YH, Yang ST, Kang SW, Kim Y, Park IS, Hahm KS, Shin SY."	Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.
DRAMP18625	KLKKLLKKWLKLLKKLLK	18	D3-K9L8W-1 (D-amino acid substitution of K9L8W)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. D-Leucine replace L-Leucine at the position 6 and 12 on the peptide K9L8W, D-Lysine replace L-Lysine at the position 18 on the peptide K9L8W. Has hemolytic activity."	"[Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=2 ¦ÌM), Staphylococcus epidermidis (MIC=4 ¦ÌM), Staphylococcus aureus (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=4 ¦ÌM), Pseudomonas aeruginosa (MIC=4 ¦ÌM), Salmonella typhimurium (MIC=2 ¦ÌM)."	[Ref.20363271]HC50=150 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20363271	Peptides. 2010 Jul;31(7):1251-61.	"Wang P, Nan YH, Yang ST, Kang SW, Kim Y, Park IS, Hahm KS, Shin SY."	Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.
DRAMP18626	KLKKLLKKWLKLLKKLLK	18	D3-K9L8W-2 (D-amino acid substitution of K9L8W)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. D-Leucine replace L-Leucine at the position 5 and 10 on the peptide K9L8W, D-Lysine replace L-Lysine at the position 15 on the peptide K9L8W. Has hemolytic activity."	"[Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=1 ¦ÌM), Staphylococcus epidermidis (MIC=4 ¦ÌM), Staphylococcus aureus (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=4 ¦ÌM), Pseudomonas aeruginosa (MIC=4 ¦ÌM), Salmonella typhimurium (MIC=2 ¦ÌM)."	[Ref.20363271]HC50=116 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20363271	Peptides. 2010 Jul;31(7):1251-61.	"Wang P, Nan YH, Yang ST, Kang SW, Kim Y, Park IS, Hahm KS, Shin SY."	Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.
DRAMP18628	KLKKLLKKWLKLLKKLLK	18	D6-K9L8W (D-amino acid substitution of K9L8W)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. D-Leucine replace L-Leucine at the position 6 and 12 on the peptide K9L8W, D-Lysine replace L-Lysine at the position 3,15 and 18 on the peptide K9L8W, D-Tryptophan replace L-Tryptophan at the position 9 on the peptide K9L8W. Weak hemolytic activity."	"[Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=1 ¦ÌM), Staphylococcus epidermidis (MIC=4 ¦ÌM), Staphylococcus aureus (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=4 ¦ÌM), Pseudomonas aeruginosa (MIC=2 ¦ÌM), Salmonella typhimurium (MIC=2 ¦ÌM)."	[Ref.20363271]HC50>800 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20363271	Peptides. 2010 Jul;31(7):1251-61.	"Wang P, Nan YH, Yang ST, Kang SW, Kim Y, Park IS, Hahm KS, Shin SY."	Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.
DRAMP18629	KLKKLLKKWLKLLKKLLK	18	D9-K9L8W-1 (D-amino acid substitution of K9L8W)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. D-Leucine replace L-Leucine at the position 2,6,10,12 and 16 on the peptide K9L8W, D-Lysine replace L-Lysine at the position 4,8,14 and 18 on the peptide K9L8W. Weak hemolytic activity."	"[Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=1 ¦ÌM), Staphylococcus epidermidis (MIC=4 ¦ÌM), Staphylococcus aureus (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2 ¦ÌM), Pseudomonas aeruginosa (MIC=2 ¦ÌM), Salmonella typhimurium (MIC=2 ¦ÌM)."	[Ref.20363271]HC50>800 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20363271	Peptides. 2010 Jul;31(7):1251-61.	"Wang P, Nan YH, Yang ST, Kang SW, Kim Y, Park IS, Hahm KS, Shin SY."	Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.
DRAMP18630	KLKKLLKKWLKLLKKLLK	18	D9-K9L8W-2 (D-amino acid substitution of K9L8W)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. D-Leucine replace L-Leucine at the position 10,12,13,16 and 17 on the peptide K9L8W, D-Lysine replace L-Lysine at the position 11,14,15 and 18 on the peptide K9L8W. Has hemolytic activity."	"[Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=2 ¦ÌM), Staphylococcus epidermidis (MIC=4 ¦ÌM), Staphylococcus aureus (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=4 ¦ÌM), Pseudomonas aeruginosa (MIC=4 ¦ÌM), Salmonella typhimurium (MIC=2 ¦ÌM)."	[Ref.20363271]HC50=154 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	20363271	Peptides. 2010 Jul;31(7):1251-61.	"Wang P, Nan YH, Yang ST, Kang SW, Kim Y, Park IS, Hahm KS, Shin SY."	Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.
DRAMP18631	VGHNADLQIKLSIRRLLAAGVLKQTKGVGA	30	H5(61¨C90) V1 (Histone H5 peptide derivative)	No entry found	Derived from Histone H5	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, Random coil"	The peptide adopts a random coil structure in water and presented an orders alpha-helix structure with 84.2 % alpha-helices in 30?mM SDS	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria.  H5(61	[Ref.29402952] Gram-positive bacteria: Listeria monocytogenes (MIC=23.1¡À8.1?¦Ìg/mL);##Gram-negative bacterium: Pseudomonas aeruginosa (MIC=16¡À0 ¦Ìg/mL)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29402952	Sci Rep. 2018 Feb 5;8(1):2411.	"Jodoin J, Hincke MT."	Histone H5 is a potent Antimicrobial Agent and a template for novel Antimicrobial Peptides.
DRAMP18632	LSIRRLLAAGVLKQTKGVGA	20	Peptide H5 (71-90) (Histone H5 peptide derivative)	No entry found	Derived from Histone H5	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. 	[Ref.29402952] Gram-negative bacterium: Pseudomonas aeruginosa (MIC=26.7¡À14.1 ¦Ìg/mL)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29402952	Sci Rep. 2018 Feb 5;8(1):2411.	"Jodoin J, Hincke MT."	Histone H5 is a potent Antimicrobial Agent and a template for novel Antimicrobial Peptides.
DRAMP18633	VGHNADLQIKLSIRRLLAAGVLKQTKGVGA	30	H5(61-90) V2 (Histone H5 peptide derivative)	No entry found	Derived from Histone H5	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	"Alpha helix, Random coil"	The peptide adopts a random coil structure in water and presented an orders alpha-helix structure with 75.5 % alpha-helices in 30?mM SDS	None	Function: Antibacterial activity against Gram-negative bacteria.  H5(61	[Ref.29402952] Gram-negative bacterium: Pseudomonas aeruginosa (MIC=33.8?¡À?26.3 ¦Ìg/mL)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29402952	Sci Rep. 2018 Feb 5;8(1):2411.	"Jodoin J, Hincke MT."	Histone H5 is a potent Antimicrobial Agent and a template for novel Antimicrobial Peptides.
DRAMP18634	VGHNADLQIKLSIRRLLAAGVLKQTKGVGA	30	H5(61-90) V3 (Histone H5 peptide derivative)	No entry found	Derived from Histone H5	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, Random coil"	The peptide adopts a random coil structure in water and presented an orders alpha-helix structure with 84.7 % alpha-helices in 30?mM SDS	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. H5(61	[Ref.29402952] Gram-positive bacteria: Listeria monocytogenes (MIC=106.7?¡À?37.0?¦Ìg/mL);##Gram-negative bacterium: Pseudomonas aeruginosa (MIC=48.0?¡À?32.4 ¦Ìg/mL)	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29402952	Sci Rep. 2018 Feb 5;8(1):2411.	"Jodoin J, Hincke MT."	Histone H5 is a potent Antimicrobial Agent and a template for novel Antimicrobial Peptides.
DRAMP18635	KLIPIASKTCPAGKNLCYKI	20	NCP-0	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Unordered structure	The peptide adopts overall content of unordered secondary structure that is 67% 	None	Function: Antibacterial activity against the Gram-negative bacteria.	[Ref.29364903] Gram-negative bacteria: Burkholderia cepacia ATCC 17759(MBC=50¦Ìg/ml);Moraxella catarrhalis ATCC 25238(MBC=1.6¦Ìg/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29364903	PLoS One. 2018 Jan 24;13(1):e0190778. 	"Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, Taddei S."	Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity.
DRAMP18636	KLIFILSKTIPAGKNLFYKI	20	NCP-3a (CTX-1 peptide derivative)	No entry found	Derived from CTX-1	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29364903] Gram-positive bacteria: Methicillin-resistant Staphylococcus aureus ATCC 43300 (MBC=6.3 ¦Ìg/ml), Staphylococcus aureus ATCC 22953 (MBC=12.5 ¦Ìg/ml), Enterococcus hirae ATCC 10541 (MBC=6.3 ¦Ìg/ml), Streptococcus agalactiae ATCC 13813 (MBC=3.1 ¦Ìg/ml);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MBC=6.3 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=25 ¦Ìg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=25 ¦Ìg/ml), Acinetobacter baumannii (human, urinary) (MBC=25 ¦Ìg/ml), Klebsiella pneumoniae subsp. pneumoniae (herpetological, cloacal) (MBC=50 ¦Ìg/ml), Burkholderia cepacia ATCC 17759 (MBC=50 ¦Ìg/ml), Moraxella catarrhalis ATCC 25238 (MBC=3.1 ¦Ìg/ml);##Fungi: Candida albicans ATCC 10231 (MBC=6.3 ¦Ìg/mL), Candida glabrata ATCC 90030 (MBC=25 ¦Ìg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=6.3 ¦Ìg/mL)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29364903	PLoS One. 2018 Jan 24;13(1):e0190778. 	"Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, Taddei S."	Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity.
DRAMP18637	KLILILSKTIPAGKNLFYKI	20	NCP-3b (CTX-1 peptide derivative)	No entry found	Derived from CTX-1	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29364903] Gram-positive bacteria: Methicillin-resistant Staphylococcus aureus ATCC 43300 (MBC=6.3 ¦Ìg/ml), Staphylococcus aureus ATCC 22953 (MBC=50 ¦Ìg/ml), Enterococcus hirae ATCC 10541 (MBC=12.5 ¦Ìg/ml), Streptococcus agalactiae ATCC 13813 (MBC=12.5 ¦Ìg/ml);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MBC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=25 ¦Ìg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=25 ¦Ìg/ml), Acinetobacter baumannii (human, urinary) (MBC=25 ¦Ìg/ml), Klebsiella pneumoniae subsp. pneumoniae (herpetological, cloacal) (MBC=25 ¦Ìg/ml), Burkholderia cepacia ATCC 17759 (MBC=25 ¦Ìg/ml), Moraxella catarrhalis ATCC 25238 (MBC=12.5 ¦Ìg/ml);##Fungi: Candida albicans ATCC 10231 (MBC=12.5 ¦Ìg/mL), Candida glabrata ATCC 90030 (MBC=100 ¦Ìg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=25 ¦Ìg/mL)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29364903	PLoS One. 2018 Jan 24;13(1):e0190778. 	"Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, Taddei S."	Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity.
DRAMP18639	CKCRRRKVHGPMIRIRKK	18	CTO17 (TO17 peptide derivative)	No entry found	Derived from TO17	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria.	[Ref.29183811] Gram-negative bacterium: Vibrio vulnificus (MIC=20 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29183811	Fish Shellfish Immunol. 2018 Jan;72:639-645. 	"He SW, Wang GH, Yue B, Zhou S, Zhang M."	"TO17: A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus."
DRAMP18640	KCRRRKVHGPMIRIRKKNL	19	TO19 (TO17 peptide derivative)	No entry found	Derived from TO17	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria.	[Ref.29183811] Gram-negative bacterium: Vibrio vulnificus (MIC=20 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29183811	Fish Shellfish Immunol. 2018 Jan;72:639-645.	"He SW, Wang GH, Yue B, Zhou S, Zhang M."	"TO17: A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus."
DRAMP18641	TWWRWW	6	KCM11	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Low activity against the Gram-negative strains. High activity against the Gram-positive strains	"[Ref.19734717] Gram-negative bacteria: Acidovorax konjaci(MEC=2.5 nM), Pseudomonas syringae pv. tomato DC3000 (MEC=5 nM), Pectobacterium carotovorum subsp. atrosepticum (MEC=5 nM), Xanthomonas albilineans (MEC=0.3 nM), Xanthomonas campestris pv. vesicatoria 833 (MEC=0.3 nM), Xanthomonas campestris pv. vesicatoria 833 pilA (MEC=0.3 nM), Xanthomonas oryzae pv. oryzae 599 (MEC=1.3 nM), Xanthomonas oryzae pv. oryzae 710 (MEC=1.3 nM), Xanthomonas oryzae pv. oryzae 090 (MEC=1.3 nM);##Gram-positive bacterium: Clavibacter michiganensis subsp. michiganensis (MEC=0.3 nM)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19734717	J Microbiol Biotechnol. 2009 Aug;19(8):792-802.	"Choi J, Moon E."	Identification of novel bioactive hexapeptides against phytopathogenic bacteria through rapid screening of a synthetic combinatorial library.
DRAMP18642	KWRWIW	6	KCM12	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: High activity against E. coli DH5	"[Ref.19734717] Gram-negative bacteria: Acidovorax konjaci (MEC=1.3 nM), Pseudomonas syringae pv. tomato DC3000 (MEC=0.3 nM), Escherichia coli DH5¦Á (MEC=1.3 nM), Pseudomonas putida (MEC=0.6 nM), Pectobacterium carotovorum subsp. carotovorum (MEC=5 nM), Pectobacterium carotovorum subsp. atrosepticum (MEC=0.6 nM), Xanthomonas albilineans (MEC=1.3 nM), Xanthomonas campestris pv. vesicatoria 833 (MEC=0.3 nM), Xanthomonas campestris pv. vesicatoria 833 pilA (MEC=0.3 nM), Xanthomonas oryzae pv. oryzae 599 (MEC=0.2 nM), Xanthomonas oryzae pv. oryzae 710 (MEC=0.2 nM), Xanthomonas oryzae pv. oryzae 090 (MEC=0.2 nM);##Gram-positive bacterium: Clavibacter michiganensis subsp. michiganensis (MEC=0.6 nM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19734717	J Microbiol Biotechnol. 2009 Aug;19(8):792-802.	"Choi J, Moon E."	Identification of novel bioactive hexapeptides against phytopathogenic bacteria through rapid screening of a synthetic combinatorial library.
DRAMP18643	KWWWRW	6	KCM21	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: High activity against E. coli DH5	"[Ref.19734717] Gram-negative bacteria: Acidovorax konjaci (MEC=0.6 nM), Pseudomonas syringae pv. tomato DC3000 (MEC=0.6 nM), Escherichia coli DH5¦Á (MEC=1.3 nM), Pseudomonas putida (MEC=1.3 nM), Pectobacterium carotovorum subsp. carotovorum (MEC=5 nM), Pectobacterium carotovorum subsp. atrosepticum (MEC=0.6 nM), Xanthomonas albilineans (MEC=0.2 nM), Xanthomonas campestris pv. vesicatoria 833 (MEC=0.2 nM), Xanthomonas campestris pv. vesicatoria 833 pilA (MEC=0.2 nM), Xanthomonas oryzae pv. oryzae 599 (MEC=0.2 nM), Xanthomonas oryzae pv. oryzae 710 (MEC=0.3 nM), Xanthomonas oryzae pv. oryzae 090 (MEC=0.3 nM);##Gram-positive bacterium: Clavibacter michiganensis subsp. michiganensis (MEC=0.3 nM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19734717	J Microbiol Biotechnol. 2009 Aug;19(8):792-802.	"Choi J, Moon E."	Identification of novel bioactive hexapeptides against phytopathogenic bacteria through rapid screening of a synthetic combinatorial library.
DRAMP18644	WRWFIH	6	KRS22	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not foundn	None	Function: High activity against XCV833 and CM at the high concentration	"[Ref.19734717] Gram-negative bacteria: Acidovorax konjaci (MEC=5 nM), Pseudomonas syringae pv. tomato DC3000 (MEC=2.5 nM), Escherichia coli DH5¦Á (MEC=5 nM), Pectobacterium carotovorum subsp. atrosepticum (MEC=2.5 nM), Xanthomonas albilineans (MEC=2.5 nM), Xanthomonas campestris pv. vesicatoria 833 (MEC=2.5 nM), Xanthomonas campestris pv. vesicatoria 833 pilA (MEC=2.5 nM), Xanthomonas oryzae pv. oryzae 599 (MEC=0.6 nM), Xanthomonas oryzae pv. oryzae 710 (MEC=1.3 nM), Xanthomonas oryzae pv. oryzae 090 (MEC=0.3 nM);##Gram-positive bacterium: Clavibacter michiganensis subsp. michiganensis (MEC=1.3 nM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19734717	J Microbiol Biotechnol. 2009 Aug;19(8):792-802.	"Choi J, Moon E."	Identification of novel bioactive hexapeptides against phytopathogenic bacteria through rapid screening of a synthetic combinatorial library.
DRAMP18647	RKWLFW	6	PAF34	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	"Function: Antifungal activity against Penicillium digitatum PHI-26, Penicillium italicum PHI-1, Penicillium expansum CMP-1, Botrytis cinerea CECT2100, Saccharomyces cerevisiae W303-1A . Antibacterial activity against Escherichia coli DH5"	"[Ref.11976121] Fungi: Penicillium digitatum PHI-26 (MIC=40 ¦ÌM, IC50=15 ¡À 1 ¦ÌM), Penicillium italicum PHI-1 (MIC=20 ¦ÌM, IC50=12 ¡À 4 ¦ÌM), Penicillium expansum CMP-1 (MIC=160 ¦ÌM, IC50> 80 ¦ÌM), Botrytis cinerea CECT2100 (MIC=60 ¦ÌM), Saccharomyces cerevisiae W303-1A (MIC>160 ¦ÌM, IC50=52 ¡À 22 ¦ÌM);##Gram-negative bacterium: Escherichia coli DH5¦Á(MIC=160 ¦ÌM, IC50>80 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	11976121	Appl Environ Microbiol. 2002 May;68(5):2453-60.	"L¨®pez-Garc¨ªa B, P¨¦rez-Pay¨¢ E, Marcos JF."	Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.
DRAMP18648	FVPWFSKFLPRIL	13	"[Pro3,DLeu9]TL(3) (Temporin L peptide derivative)"	No entry found	Derived from Temporin L	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	The analogues bearing a D residue showed a reduction in the percentage of helicity compared to the corresponding L analogues in the MMs 	None	"Function: Antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteria and Fungi. The position 9 of [Pro3,DLeu9]TL(3) is D-Leucine, D-Proline replace L-Proline at the position 10 on the  peptide [Pro3,DLeu9]TL(2)."	"[Ref.28863356] Gram-positive bacterium: Bacillus megaterium Bm11 (MIC=3.125¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=25¦ÌM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=50¦ÌM), Escherichia coli D21 (MIC=50¦ÌM), Pseudomonas syringae pv tabaci 1918 (MIC=50¦ÌM);##Yeasts: Candida albicans ATCC 10231 (MIC=3.125¦ÌM), Candida crusei ATCC 6258 (MIC=3.125¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28863356	Eur J Med Chem. 2017 Oct 20;139:750-763.	"Merlino F, Carotenuto A, Casciaro B, Martora F, Loffredo MR, Di Grazia A, Yousif AM, Brancaccio D, Palomba L, Novellino E, Galdiero M, Iovene MR, Mangoni ML, Grieco P."	"Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities"
DRAMP18649	FQWQRNPRKVR	11	HLP6 (HLP2  peptide derivative)	No entry found	Derived from the peptide HLP 2	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria.  HLP 6 had a proline substituted for methionine in HLP 2.	[Ref.9596699] Gram-negative bacteria: Escherichia coli NCTC 10418 (MIC=750 ¦ÌM);##Gram-negative bacterium: Staphylococcus aureus (MIC=250 ¦ÌM);##Clinical isolates: Acinetobacter sp.(MIC=10 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9596699	Infect Immun. 1998 Jun;66(6):2434-40.	"Chapple DS, Mason DJ, Joannou CL, Odell EW, Gant V, Evans RW."	Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.
DRAMP18650	FQWQRNMRKVR	11	HLP7 (HLP2  peptide derivative)	No entry found	Derived from the peptide HLP 2	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. HLP 7 is the d form of HLP 2.	"[Ref.9596699] Gram-negative bacteria: Escherichia coli NCTC 8007 (MIC=18 ¦ÌM), Escherichia coli NCTC 10418 (MIC=40 ¦ÌM);##Gram-negative bacterium: Staphylococcus aureus (MIC=14 ¦ÌM);##Clinical isolates: Acinetobacter sp. (MIC=0.3 ¦ÌM), Klebsiella sp. strain 3105 (MIC=80 ¦ÌM), Providencia stuartii (MIC=110 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9596699	Infect Immun. 1998 Jun;66(6):2434-40.	"Chapple DS, Mason DJ, Joannou CL, Odell EW, Gant V, Evans RW."	Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.
DRAMP18656	MRTGNAD	7	"Microcin 7 (Bacteriocin; Escherichia coli, Bacteria)"	No entry found	Bacteriocin	Not found	Escherichia coli	"Antimicrobial, Antibacterial, Anti-Gram-"	Natural	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.2861788] Gram-negative bacteria: Escherichia coli , Klebsiella pneumoniae, Salmonella typhi, Salmonella typhimurium, Salmonella sp., Shigella flexneri, Shigella sp., Proteus mirabilis"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2861788	Antimicrob Agents Chemother. 1985 May;27(5):791-7.	"Garcia-Bustos JF, Pezzi N, Mendez E."	"Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli."
DRAMP18658	FLPIVAKLLSGLL	13	"Temporin-PE (Edible frogs, amphibians, animals)"	A0A2H4WAJ8	Not found	Not found	Pelophylax kl.esculentus(Europe edible frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-cancer, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.Has hemolytic activity."	"[Ref.29191658]Gram-positive bacteria: Staphylococcus aureus (MIC=2.0 ¦ÌM), Methicillin-resistant Staphylococcus aureus (MIC=4.0 ¦ÌM), Enterococcus faecalis (MIC=8.0 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=16.0 ¦ÌM);##Fungus: Candida albicans (MIC=4.0 ¦ÌM).##Cancer cell lines: NCI-H157 (IC50=34.56 ¦ÌM), U251MG (IC50=25.13 ¦ÌM), PC-3 (IC50=38.56 ¦ÌM), MDA-MB-435s (IC50=33.23 ¦ÌM), HMEC-1 (IC50=58.62 ¦ÌM)."	[Ref.29191658]HC50=39.64 ¦ÌM against horse red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29191658	Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546.	"Sang M, Wu Q, Xi X, Ma C, Wang L, Zhou M, Burrows JF, Chen T."	"Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus."
DRAMP18659	VKVGINGFGRIGRLVTRAAFHGKKVEVVAIND	32	"YFGAP-OH(Yellowfin tuna GAPDH-related antimicrobial peptide; fish, animals)"	No entry found	Not found	Not found	Yellowfin tuna (Thunnus albacares)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Alpha helix and  Beta strands	One Alpha helix and two parallel Beta strands	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacterial.Weak hemolytic activity.
YFGAP-OH is the C-terminus amidated modification of YFGAP."	"[Ref.22771964]Gram-positive bacteria: Bacillus subtilis KCTC1021 (MIC=13.0 ¦Ìg/ml), Bacillus subtilis RM125 (MIC=1.2 ¦Ìg/ml), Micrococcus luteus ATCC9341 (MIC=6.5 ¦Ìg/ml), Staphylococcus aureus RM4220 (MIC=125.0 ¦Ìg/ml), Staphylococcus aureus KCTC1621 (MIC=11.0 ¦Ìg/ml), Streptococcus iniae FP5229 (MIC=17.0 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli D31 (MIC=6.2 ¦Ìg/ml), Escherichia coli KCTC1116 (MIC=5.0 ¦Ìg/ml), Escherichia coli ML35p (MIC=3.0 ¦Ìg/ml), Enterobacter cloacae KCTC1685 (MIC=12.0 ¦Ìg/ml), Pseudomonas aeroginosa KCTC2004 (MIC=3.7 ¦Ìg/ml), Salmonella enterica KCTC2514 (MIC=3.1 ¦Ìg/ml), Shigella flexneri KCTC2517 (MIC=5.0 ¦Ìg/ml), Aeromonas hydrophila KCTC2358 (MIC=8.0 ¦Ìg/ml), Vibrio parahemolyticus KCCM41664 (MIC=3.2 ¦Ìg/ml)"	[Ref.22771964]0.4% hemolysis at 100 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22771964	Fish Shellfish Immunol. 2012 Oct;33(4):743-52. doi: 10.1016/j.fsi.2012.06.023.	"Seo JK, Lee MJ, Go HJ, Park TH, Park NG."	"Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares."
DRAMP18660	VKVGINGFGRIGRLVTRAAFHGKKVEVVAIND	32	"YFGAP-NH2(Yellowfin tuna GAPDH-related antimicrobial peptide; fish, animals)"	No entry found	Not found	Not found	Yellowfin tuna(Thunnus albacares)	"Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-"	Not found	Alpha helix and  Beta strands	One Alpha helix and two parallel Beta strands	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.
YFGAP-NH2 is the C-terminus free forms of YFGAP."	"[Ref.22771964]Gram-positive bacteria: Bacillus subtilis KCTC1021 (MIC=5.4 ¦Ìg/ml), Bacillus subtilis RM125 (MIC=0.7 ¦Ìg/ml), Micrococcus luteus ATCC9341 (MIC=6.0 ¦Ìg/ml), Staphylococcus aureus RM4220 (MIC=34.0 ¦Ìg/ml), Staphylococcus aureus KCTC1621 (MIC=3.7 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli D31 (MIC=1.9 ¦Ìg/ml), Escherichia coli KCTC1116 (MIC=3.3 ¦Ìg/ml), Escherichia coli ML35p (MIC=0.4 ¦Ìg/ml), Enterobacter cloacae KCTC1685 (MIC=3.5 ¦Ìg/ml), Pseudomonas aeroginosa KCTC2004 (MIC=1.7 ¦Ìg/ml), Salmonella enterica KCTC2514 (MIC=0.9 ¦Ìg/ml), Shigella flexneri KCTC2517 (MIC=2.0 ¦Ìg/ml), Aeromonas hydrophila KCTC2358 (MIC=3.6 ¦Ìg/ml), Vibrio parahemolyticus KCCM41664 (MIC=0.9 ¦Ìg/ml);##Fungi: Candida albicans KCTC7965 (MIC=125.0 ¦Ìg/ml)"	[Ref.22771964]2.7% hemolysis at 100 ¦Ìg/ml against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22771964	Fish Shellfish Immunol. 2012 Oct;33(4):743-52. doi: 10.1016/j.fsi.2012.06.023.	"Seo JK, Lee MJ, Go HJ, Park TH, Park NG."	"Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares."
DRAMP18661	GWLDVAKKIGKAAFNVAKNFL	21	"Ctx-Ha (Frogs, amphibians, animals)"	No entry found	Belongs to the Ceratotoxin family	Not found	Hypsiboas albopunctatus	"Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-"	Not found	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	[Ref.22391524]Gram-positive bacterium: Staphylococcus aureus (MIC=1.7 ¦Ìmol/L; MMC=6.8 ¦Ìmol/L);##Gram-negative bacterium: Escherichia coli (MIC=3.4 ¦Ìmol/L; MMC=3.4 ¦Ìmol/L);##Fungi: Candida albicans (MIC=54.6 ¦Ìmol/L; MMC<100 ¦Ìmol/L)	[Ref.22391524]HC50=37.3¡À1.4 ¦Ìmol/L against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	22391524	Antimicrob Agents Chemother. 2012 Jun;56(6):3004-10.	"Lorenz¨®n EN, Cespedes GF, Vicente EF, Nogueira LG, Bauab TM, Castro MS, Cilli EM."	Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.
DRAMP18662	LLAGLAANFLPKIFCKITRKC	21	"Brevinin 21 (Brevinin-1E truncated peptide 21; Frogs, amphibians, animals)"	No entry found	Derived from the peptide Brevinin-1E 	Not found	Rana esculenta	"Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-"	Not found	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.9748603]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC=12.5 ¦Ìg/ml), Methicillin resistant Staphylococcus aureus (MIC=25 ¦Ìg/ml), Micrococcus luteus ATCC 9341 (MIC=6.25 ¦Ìg/ml);##Gram-negative bacteria:Escherichia coli ATCC 2592 (MIC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=12.5 ¦Ìg/ml);##Fungus: Candida albicans ATCC 36232 (MIC=6.25 ¦Ìg/ml)."	[Ref.9748603]HD50=77 ¦Ìg/ml(oxidized); HD50=110 ¦Ìg/ml(reduced) against mouse red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9748603	Biochim Biophys Acta. 1998 Sep 8;1387(1-2):239-48.	"Kwon MY, Hong SY, Lee KH."	"Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta."
DRAMP18663	GLAANFLPKIFCKITRKC	18	"Brevinin 18 (Brevinin-1E truncated peptide 18; Frogs, amphibians, animals)"	No entry found	Derived from the peptide Brevinin-1E 	Not found	Rana esculenta	"Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-"	Not found	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity."	"[Ref.9748603]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC=25 ¦Ìg/ml), Methicillin resistant Staphylococcus aureus (MIC=100 ¦Ìg/ml), Micrococcus luteus ATCC 9341 (MIC=12.5 ¦Ìg/ml);##Gram-negative bacteria:Escherichia coli ATCC 2592 (MIC=25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=12.5 ¦Ìg/ml);##Fungus: Candida albicans ATCC 36232 (MIC=25 ¦Ìg/ml)."	[Ref.9748603]HD50=146 ¦Ìg/ml(oxidized); HD50=230 ¦Ìg/ml(reduced) against mouse red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9748603	Biochim Biophys Acta. 1998 Sep 8;1387(1-2):239-48.	"Kwon MY, Hong SY, Lee KH."	"Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta."
DRAMP18664	ANFLPKIFCKITRKC	15	"Brevinin 15 (Brevinin-1E truncated peptide 15; Frogs, amphibians, animals)"	No entry found	Derived from the peptide Brevinin-1E 	Not found	Rana esculenta	"Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-"	Not found	Alpha helix 	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.9748603]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC=100 ¦Ìg/ml), Micrococcus luteus ATCC 9341 (MIC=25 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 2592 (MIC=50 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=50 ¦Ìg/ml);##Fungus: Candida albicans ATCC 36232 (MIC=50 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9748603	Biochim Biophys Acta. 1998 Sep 8;1387(1-2):239-48.	"Kwon MY, Hong SY, Lee KH."	"Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta."
DRAMP18665	INLKALAALAKKIL	14	"Mastoparan-L (MP-L; insects, arthropods, invertebrates, animals)"	P01514	Belongs to the tetradecapeptide family	Not found	Vespula lewisii (Korean yellow-jacket isp) (Vespula flaviceps lewisii)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	1D7N resolved by NMR.	"Function: Mast cell degranulating peptide. Activates G proteins that couple to phospholipase C. May be able to switch from an in-plane to a transmembrane orientation in lipid bilayers. Antibacterial activity against Gram-positive bacteria and  Gram-negative bacteria. Has hemolytic activity.
PTM: Leucine amide at the position 14.
Tissue specificity: Expressed by the venom gland."	"[Ref.27423268]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=12.5 ¦ÌM), Enterococcus faecalis ATCC 29212 (MIC=25 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=50 ¦ÌM), Klebsiella pneumoniae ATCC 13883 (MIC=12.5 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=2.7 ¦ÌM)"	[Ref.27423268]40% hemolysis at 10¦ÌM against rat red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27423268	Biochim Biophys Acta. 2016 Nov;1858(11):2699-2708.	"Irazazabal LN, Porto WF, Ribeiro SM, Casale S, Humblot V, Ladram A, Franco OL."	Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan.
DRAMP18666	GLGSVFGRLARILGRVIPKV	20	"P1 (Pilosulin-1 1-20; Ant, insects, arthropods, invertebrates, animals)"	Q07932	"Derived from the peptide Pilosulin-1, Belongs to the pilosulin family."	Not found	Myrmecia pilosula (Jumper ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-"	Protein level	Alpha helix 	Not found	5X3L resolved by NMR.	"Function: Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Adopts an alpha-helical structure.
Allergenic properties: Causes an allergic reaction in human. Binds to IgE."	"[Ref.15639237]Gram-positive bacteria: Staphylococcus aureus 710A (MIC=4 ¦ÌM), Bacillus megaterium BM11 (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli ML-35 (MIC=2 ¦ÌM), Pseudomonas aeruginosa ATCC27853 (MIC=8 ¦ÌM), Salmonella typhimurium ATCC14028 (MIC=8 ¦ÌM).##Drug resistant clinical isolates: Staphylococcus simulans 22 (MIC=2 ¦ÌM), Micrococcus luteus (MIC=0.5 ¦ÌM), Enterococcus spp. I-11305b (MIC=2 ¦ÌM), Enterococcus spp. I-11054 (MIC=2 ¦ÌM), Staphylococcus haemolyticus I-10925 (MIC=2 ¦ÌM), Staphylococcus epidermidis LT1324 (MIC=2 ¦ÌM), Staphylococcus aureus 5185 (MIC=2 ¦ÌM), Staphylococcus aureus I-11574 (MIC=2 ¦ÌM), Staphylococcus aureus LT1338 (MIC=3 ¦ÌM), Staphylococcus aureus T1334 (MIC=1.5 ¦ÌM), Citrobacter freundii I-11090 (MIC=2 ¦ÌM), Klebsiella pneumoniae I-10910 (MIC=2 ¦ÌM), Escherichia coli I-11276b (MIC=4 ¦ÌM), Escherichia coli O-19592 (MIC=2 ¦ÌM), Stenotrophomonas maltophilia O-16451 (MIC=2 ¦ÌM), Stenotrophomonas maltophilia I-10717 (MIC=2 ¦ÌM), Pseudomonas aeruginosa 4991 (MIC=4 ¦ÌM), Pseudomonas aeruginosa I-10968 (MIC=4 ¦ÌM), Candida albicans I-11301 (MIC=4 ¦ÌM)."	"[Ref.15639237]20% hemolysis at 10¦ÌM, 100% hemolysis at 100¦ÌM against human red blood cells"	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15639237	Arch Biochem Biophys. 2005 Feb 15;434(2):358-64.	"Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A."	Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.
DRAMP18667	KETWWETWWTEWSQPKKKRKV	21	Pep-1	No entry found	Not found	Not found	Derived from the nuclear localization sequence of simian virus 40 large T antigen and from reverse t	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria.No hemolytic activity.	"[Ref.16945333]Gram-positive bacteria: Bacillus subtilis (KCTC 3068) (MIC=8.0 ¦ÌM), Staphylococcus aureus (KCTC 1621) (MIC=64.0 ¦ÌM), Staphylococcus epidermidis (KCTC 1917) (MIC=64.0 ¦ÌM);##Gram-negative bacteria: Escherichia coli (KCTC 1682) (MIC=32.0 ¦ÌM);##Antibiotic-resistant bacteria: MDRPA 1 (CCARM 2092) (MIC=32.0 ¦ÌM), MDRPA 3 (CCARM 2109) (MIC=32.0 ¦ÌM)."	[Ref.16945333]Non-hemolysis at 200 ¦ÌM against human red blood cells	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	16945333	Biochem Biophys Res Commun. 2006 Oct 20;349(2):769-74.	"Zhu WL, Lan H, Park IS, Kim JI, Jin HZ, Hahm KS, Shin SY."	Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1.
DRAMP18668	PSVQGAAAQLTADVKK	16	AI-hemocidins 1 (Hb-1  truncated peptide)	No entry found	Belongs to truncated Hb-1 	Not found	Arca inflata	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria.	"[Ref.28661457] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=47.35 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=47.35 ¦ÌM), Pseudomonas aeruginosa clinical isolate (MIC=47.35 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28661457	Mar Drugs. 2017 Jun 29;15(7). pii: E205.	"Li C, Zhu J, Wang Y, Chen Y, Song L, Zheng W, Li J, Yu R."	"Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflata"
DRAMP18669	ISAAEFGKINGPIKK	15	AI-hemocidins 3 (Hb-1  truncated peptide)	No entry found	Belongs to truncated Hb-1 	Not found	Arca inflata	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria.	[Ref.28661457] Gram-negative bacterium: Pseudomonas aeruginosa ATCC 27853 (MIC=95.37 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28661457	Mar Drugs. 2017 Jun 29;15(7). pii: E205.	"Li C, Zhu J, Wang Y, Chen Y, Song L, Zheng W, Li J, Yu R."	"Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflata"
DRAMP18671	KCRRRKVHGPMIRIRKK	17	TO17 (TFPI-1 C-terminal peptide)	No entry found	Belongs to the TFPI-1 C-terminal peptide	Not found	Red drum (Sciaenops ocellatus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria.	"[Ref.29183811] Gram-positive bacteria: Micrococcus luteus (MIC=9 ¦ÌM; MBC=18 ¦ÌM), Staphylococcus aureus (MIC=4 ¦ÌM; MBC=8 ¦ÌM);##Gram-negative bacterium: Vibrio vulnificus (MIC= 80 ¦ÌM; MBC=80 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	29183811	Fish Shellfish Immunol. 2018 Jan;72:639-645. 	"He SW, Wang GH, Yue B, Zhou S, Zhang M."	"TO17: A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus."
DRAMP18672	APPPGLSAGV	10	"Peptide 7 (Mollusca/molluscs/mollusks, invertebrates, animals)"	No entry found	Not found	Not found	Marine snail Rapana venosa	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacterium. 	[Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Klebsiella pneumoniae 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21703315	Peptides. 2011 Jul;32(7):1477-83.	"Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W."	Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.
DRAMP18673	ELVRKNVDHLSTPDVLELV	19	"Peptide 3 (Mollusca/molluscs/mollusks, invertebrates, animals)"	No entry found	Not found	Not found	Marine snail Rapana venosa	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacterium. 	[Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Klebsiella pneumoniae 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21703315	Peptides. 2011 Jul;32(7):1477-83.	"Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W."	Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.
DRAMP18674	SPPNQPSIMTFDYAKTNK	18	"Peptide 2 (Mollusca/molluscs/mollusks, invertebrates, animals)"	No entry found	Not found	Not found	Marine snail Rapana venosa	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacterium. 	[Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Klebsiella pneumoniae 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21703315	Peptides. 2011 Jul;32(7):1477-83.	"Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W."	Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.
DRAMP18675	SLPPTLEEEFNMKKMG	16	"Peptide 4 (Mollusca/molluscs/mollusks, invertebrates, animals)"	No entry found	Not found	Not found	Marine snail Rapana venosa	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacterium. 	[Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Klebsiella pneumoniae 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21703315	Peptides. 2011 Jul;32(7):1477-83.	"Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W."	Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.
DRAMP18676	SPPSEQLGKSFNF	13	"Peptide 5 (Mollusca/molluscs/mollusks, invertebrates, animals)"	No entry found	Not found	Not found	Marine snail Rapana venosa	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacterium. 	[Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Klebsiella pneumoniae 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21703315	Peptides. 2011 Jul;32(7):1477-83.	"Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W."	Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.
DRAMP18677	SPPPGESKVDMSFNYALSNPAQ	22	"Peptide 6 (Mollusca/molluscs/mollusks, invertebrates, animals)"	No entry found	Not found	Not found	Marine snail Rapana venosa	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacterium. 	[Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Klebsiella pneumoniae 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21703315	Peptides. 2011 Jul;32(7):1477-83.	"Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W."	Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.
DRAMP18678	APPPGYAMESDSFS	14	"Peptide 8 (Mollusca/molluscs/mollusks, invertebrates, animals)"	No entry found	Not found	Not found	Marine snail Rapana venosa	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacterium. 	[Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Klebsiella pneumoniae 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21703315	Peptides. 2011 Jul;32(7):1477-83.	"Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W."	Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.
DRAMP18679	FPPPGESAVDMSFFYALSNP	20	"Peptide 9 (Mollusca/molluscs/mollusks, invertebrates, animals)"	No entry found	Not found	Not found	Marine snail Rapana venosa	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacterium. 	[Ref.21703315] Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacterium: Klebsiella pneumoniae 	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	21703315	Peptides. 2011 Jul;32(7):1477-83.	"Dolashka P, Moshtanska V, Borisova V, Dolashki A, Stevanovic S, Dimanov T, Voelter W."	Antimicrobial proline-rich peptides from the hemolymph of marine snail Rapana venosa.
DRAMP18693	RPKPQQFFGLM	11	"Substance P (Mammals, animals)"	"P67932, P67933"	Belongs to the tachykinin family.	TAC1	Not found	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Substance P possesses direct antimicrobial activity. Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.12074933]Gram-negative bacteria: Escherichia coli (MIC=0.06%), Proteus vulgaris (MIC=0.13%), Pseudomonas aeruginosa (MIC=0.13%) ;##Gram-positive bacteria: Staphylococcus aureus (MIC=0.007%), Enterococcus faecalis (MIC=0.13%);##Yeast: Candida albicans (MIC=0.25%)"	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12074933	Life Sci. 2002 Jul 5;71(7):747-50.	"Kowalska K, Carr DB, Lipkowski AW."	Direct antimicrobial properties of substance P.
DRAMP18694	RPKPQQWFWLM	11	"substance P antagonist (Mammals, animals)"	No entry found	Not found	Not found	Not found	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.12074933]Gram-negative bacteria: Escherichia coli (MIC=0.13%), Proteus vulgaris (MIC=0.13%), Pseudomonas aeruginosa (MIC=0.13%) ;##Gram-positive bacteria: Staphylococcus aureus (MIC=0.13%), Enterococcus faecalis (MIC=0.13%);##Yeast: Candida albicans (MIC=0.03%)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12074933	Life Sci. 2002 Jul 5;71(7):747-50.	"Kowalska K, Carr DB, Lipkowski AW."	Direct antimicrobial properties of substance P.
DRAMP18696	FQWQRNMRKVRGPPVS	16	HLP1 (Lactotransferrin truncated peptide)	"P02788, A0A161I202"	Belongs to the Lactotransferrin	LTF	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. HLP 1 corresponded to the loop region of human lactoferricin (residues 20 to 35)."	"[Ref.9596699] Gram-negative bacteria: Escherichia coli NCTC 8007 (MIC=500 ¦ÌM), Escherichia coli NCTC 10418 (MIC=500¦ÌM);##Gram-positive bacterium: Staphylococcus aureus (MIC=500 ¦ÌM);##Clinical isolates: Acinetobacter sp.(MIC=2 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9596699	Infect Immun. 1998 Jun;66(6):2434-40.	"Chapple DS, Mason DJ, Joannou CL, Odell EW, Gant V, Evans RW."	Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.
DRAMP18697	FQWQRNMRKVR	11	HLP2 (Lactotransferrin truncated peptide)	"P02788, A0A161I202"	Belongs to the Lactotransferrin	Not found	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. HLP 2 corresponded to the alpha-helical region of the loop in its native conformation (residues 20 to 30).	"[Ref.9596699] Gram-negative bacteria: Escherichia coli NCTC 8007 (MIC=290 ¦ÌM), Escherichia coli NCTC 10418 (MIC=579 ¦ÌM);##Gram-positive bacterium: Staphylococcus aureus (MIC=14 ¦ÌM);##Clinical isolates: Acinetobacter sp. (MIC=0.86 ¦ÌM), Enterobacter aerogenes (MIC=290 ¦ÌM), Klebsiella sp. strain 3105 (MIC=290 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9596699	Infect Immun. 1998 Jun;66(6):2434-40.	"Chapple DS, Mason DJ, Joannou CL, Odell EW, Gant V, Evans RW."	Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.
DRAMP18699	FLGGLLASLLGKI	13	"Pleurain-B1 (Frogs, amphibians, animals)"	"B5L1B2, B5L1B4, B5L1B6, B5L1B3"	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.19028675]Gram-negative bacterium: Escherichia coli(MIC=25 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ¦Ìg/ml), Bacillus subtilis (MIC=3.1 ¦Ìg/ml);##Yeast: Candida albicans (MIC=1.6¦Ìg /ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP18700	YPELQQDLIARLL	13	"Pleurain-C1 (Frogs, amphibians, animals)"	B5L1A8	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=50 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ¦Ìg/ml), Bacillus subtilis (MIC=3.1 ¦Ìg/ml);##Yeast: Candida albicans(MIC=25 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP18701	FRSGILKLASKIPSVLCAVLKNC	23	"Pleurain-D4 (Frogs, amphibians, animals)"	B5L1I4	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=50 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ¦Ìg/ml), Bacillus subtilis (MIC=50 ¦Ìg/ml);##Yeast: Candida albicans(MIC=25 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP18702	AKAWGIPPHVIPQIVPVRIRPLCGNV	26	"Pleurain-E1 (Frogs, amphibians, animals)"	B5L1I5	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	[Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=25 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6..3 ¦Ìg/ml)##Yeast: Candida albicans (MIC=25 ¦Ìg/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP18703	GFWDSVKEGLKNAAVTILNKIKCKISECPPA	31	"Pleurain-G1 (Frogs, amphibians, animals)"	B5L1I8	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=50 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=50 ¦Ìg/ml), Bacillus subtilis (MIC=100 ¦Ìg/ml);##Yeast: Candida albicans(MIC=12.5 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP18704	FIPGLRRLFATVVPTVVCAINKLPPG	26	"Pleurain-J1 (Frogs, amphibians, animals)"	B5L1L0	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=12.5 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ¦Ìg/ml), Bacillus subtilis (MIC=50 ¦Ìg/ml);##Yeast: Candida albicans(MIC=6.3 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP18705	GFFDRIKALTKNVTLELLNTITCKLPVTPP	30	"Pleurain-N1 (Frogs, amphibians, animals)"	B5L1L8	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	[Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=50 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ¦Ìg/ml);##Yeast: Candida albicans (MIC=12.5 ¦Ìg/ml).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP18706	CVHWMTNTARTACIAP	16	"Pleurain-R1 (Frogs, amphibians, animals)"	No entry found	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Rana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.19028675]Gram-negative bacterium: Escherichia coli (MIC=100 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ¦Ìg/ml), Bacillus subtilis (MIC=100 ¦Ìg/ml);##Yeast: Candida albicans(MIC=50 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP18707	RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPL	60	"BACTENECIN 7 (bac 7, Pro-rich; bovine cathelicidin, cattle, ruminant, mammals, animals)"	P19661	Belongs to the cathelicidin family.	CATHL3	Bos taurus (Bovine neutrophils)	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Not found	Rich	Not found	4JWC resolved by NMR	"Function: Antibacterial activity against an array of gram-negative and gram-positive bacteria.
PTM: Elastase is responsible for its maturation."	"[Ref.2777377] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12 ?g/ml in Murller-Hinton, MIC=50 ?g/ml in Iso-Sensitest), Salmonella typhimurium LT2 (MIC=12 ?g/ml in Murller-Hinton, MIC=200 ?g/ml in Iso-Sensitest), Salmonella typhimurium ATCC 14028 (MIC=25 ?g/ml in Murller-Hinton, MIC=100 ?g/ml in Iso-Sensitest), Klebsiella pneumoniae ATCC 13883 (MIC=12 ?g/ml in Murller-Hinton, MIC=200 ?g/ml in Iso-Sensitest), Enterobacter cloacae ATCC 13047 (MIC=25 ?g/ml in Murller-Hinton, MIC=200 ?g/ml in Iso-Sensitest), Pseudomonas aeruginosa ATCC 7700 (MIC=50 ?g/ml in Murller-Hinton);##Gram-positive bacterium: Staphylococcus epidermidis ATCC 12228 (MIC=200 ?g/ml in Murller-Hinton, MIC=200 ?g/ml in Iso-Sensitest)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2777377	Infect Immun. 1989 Oct;57(10): 3142-6.	"Gennaro R, Skerlavaj B, Romeo D."	"Purification, composition, and activity of two bactenecins, antibacterial peptides of bovine neutrophils."
DRAMP18708	ALWMTLLKKVLKAAAKAALNAVLVGANA	28	"Dermaseptin-S4 (DRS-S4, DS4; frog, amphibians, animals)"	P80280	Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfami	Not found	Phyllomedusa sauvagei (Sauvage's leaf frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix 	Not found	2DD6 resolved by NMR	"Function: Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1. Probably acts by disturbing membrane functions with its amphipathic structure. Binds to healthy erythrocytes (this binding is receptor independent), and has strong hemolytic activity. Does not bind to P.falciparum infected erythrocytes, but accumulates within the parasite. Kills the parasite, and only at high concentrations has a hemolytic activity on the host cell."	"[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1"	[Swiss_Prot Entry P80280]Strong hemolytic activity	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8306981	Eur. J. Biochem. 1994; 219:145-154.	"Mor A, Nicolas P."	Isolation and structure of novel defensive peptides from frog skin.
DRAMP18711	GRKSDCFRKNGFCAFLKCPYLTLISGLCSFHLC	33	"Chicken Heterophil Peptide 2 (CHP-2, avian beta-defensin, birds, animals)"	P80390	Belongs to the beta-defensin family.	Not found	Gallus gallus (Chicken)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge	Not found	None	"Function: Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	7964174	J. Leukoc. Biol. 1994; 56: 661-665.	"Evans EW, Beach GG, Wunderlich J, Harmon BG."	Isolation of antimicrobial peptides from avian heterophils.
DRAMP18712	GFGKAFHSVSNFAKKHKTA	19	"Styelin A (Tunicate, invertebrates, animals)"	P81469	Belongs to the Cecropins family.	Not found	Styela clava (Sea squirt)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Helix 	Not found	None	"Function: Bactericidal against several Gram-positive and Gram-negative bacteria.
Tissue specificity: Hemocytes and pharyngeal tissues."	"[Ref.9467865] Gram positive bacteria: Listeria monocytogenes EGD (MIC=2 ?g/ml), Staphylococcus aureus 930918-3 (MIC=6 ?g/ml), Enterococcus faecalis 94.132 (MIC=2 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa MR 3007 (MIC=4 ?g/ml), Escherichia coli ML-35p (MIC=2.7 ?g/ml), Salmonella typhimurium 14028S (MIC=5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9467865	Comp. Biochem. Physiol. 1997; 118:515-521	"Lee IH, Cho Y, Lehrer RI."	"Styelins, broad-spectrum antimicrobial peptides from the solitary tunicate, Styela clava."
DRAMP18713	GFGPAFHSVSNFAKKHKTA	19	"Styelin B (Tunicate, invertebrates, animals)"	P81470	Belongs to the Cecropins family.	Not found	Styela clava (Sea squirt)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Helix 	Not found	None	"Function: Bactericidal against several Gram-positive and Gram-negative bacteria.
Tissue specificity: Hemocytes and pharyngeal tissues."	"[Ref.9467865] Gram positive bacteria: Listeria monocytogenes EGD (MIC=2 ?g/ml), Staphylococcus aureus 930918-3 (MIC=6 ?g/ml), Enterococcus faecalis 94.132 (MIC=2 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa MR 3007 (MIC=4.5 ?g/ml), Escherichia coli ML-35p (MIC=2.7 ?g/ml), Salmonella typhimurium 14028S (MIC=5 ?g/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9467865	Comp. Biochem. Physiol. 1997; 118:515-521	"Lee IH, Cho Y, Lehrer RI."	"Styelins, broad-spectrum antimicrobial peptides from the solitary tunicate, Styela clava."
DRAMP18714	IIGGR	5	"Cathepsin G(1-5) (Human, primates, mammals, animals)"	No entry found	Belongs to the Cathepsin G N-terminal 1-5 truncted peptide.	Not found	Homo sapiens	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Bactericidal activity against Gram-positive and Gram-negative bacteria.	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2116408	J Biol Chem. 1990 Aug 15;265(23):13584-8. 	"Bangalore N, Travis J, Onunka VC, Pohl J, Shafer WM."	Identification of the primary antimicrobial domains in human neutrophil cathepsin G.
DRAMP18715	HPQYNQR	7	"Cathepsin G(77-83) (Human, primates, mammals, animals)"	No entry found	Belongs to the Cathepsin G 77-83 truncted peptide.	Not found	Homo sapiens	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Bactericidal activity against Gram-positive and Gram-negative bacteria.	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	2116408	J Biol Chem. 1990 Aug 15;265(23):13584-8. 	"Bangalore N, Travis J, Onunka VC, Pohl J, Shafer WM."	Identification of the primary antimicrobial domains in human neutrophil cathepsin G.
DRAMP18716	PDPAKTAPKKGSKKAVTKA	19	"Histone H2B-1(HLP-1) (fish, animals)"	P81903	Belongs to the histone H2B family.	Not found	Ictalurus punctatus (Channel catfish) (Silurus punctatus)	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	The nucleosome is a histone octamer 	Not found	None	"Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad-spectrum antimicrobial and antibacterial activity. It is important in the antimicrobial defenses of fish skin and possesses strong activity against saprolegnia, the most common fungal infection in fish. It is also inhibitory to fish bacterial pathogens, such as aeromonas hydrophila, vibrio alginolyticus and Escherichia coli D31.
PTM: Monoubiquitination at the C-terminal Lys gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation. "	[Ref.9645227] Gram negative bacteria: Escherichia coli (MIC=0.37¡À0.023 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	9645227	Cell. Mol. Life Sci. 1998; 54:467-475	"Robinette D., Wada S., Arroll T., Levy MG., Miller WL., Noga EJ."	Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: characterization of broad-spectrum histone-like antimicrobial proteins.
DRAMP18717	EFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS	37	"Charybdotoxin (Yellow scorpions, arachnids, Chelicerata, arthropods, invertebrates, animals)"	No entry found	Not found	Not found	Leiurus quinquestriatus hebraeus 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Combine Helix and Beta structure 	Not found	2CRD resolved by NMR	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.15118082]Gram-positive bacteria: Bacillus subtilis (Inhibition zone=4 mm completely inhibit in PH5.5, Inhibition zone=7 mm incompletely inhibit and Inhibition zone=6 mm in PH7.5 completely inhibit at 10 ¦Ìg/well), Staphylococcus aureus  (Inhibition zone=3 mm incompletely inhibit in PH5.5, Inhibition zone=6 mm incompletely inhibit and Inhibition zone=1 mm completely inhibit in PH7.5 at 10 ¦Ìg/well);##Gram-negative bacteria: Escherichia coli (Inhibition zone=2 mm incompletely inhibit in PH5.5, Inhibition zone=8 mm incompletely inhibit in PH7.5 at 10 ¦Ìg/well);##Fungi: Candida albicans (Inhibition zone=13 mm completely inhibit in PH5.5, Inhibition zone=15 mm in PH7.5 completely inhibit at 10 ¦Ìg/well)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	15118082	Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8.	"Yount NY, Yeaman MR."	Multidimensional signatures in antimicrobial peptides.
DRAMP18718	GDDDDDD	7	"SAAP fraction 2 (Surfactant-associated anionic peptides; Asp-rich; sheep, ruminant, mammals, animals)"	No entry found	Not found	Not found	Ovis aries	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Rich	Not found	None	Function: Antibacterial activity against negative bacteria.  No amidation at the C-terminus	"[Ref.8552650] Gram-negative bacterium: Pasteurella haemolytica (MBC50=0.04 mM in Zn-saline, MBC50=11.49 mM in Test buffer; Peptide/surfactant mixture MBC50=0.05 mM in Zn-saline, MBC50=6.44 mM in Test buffer; Peptide/serum mixture MBC50=0.05 mM in Zn-saline, MBC50=10.38 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.06 mM in Zn-saline, MBC50=5.93 mM in Test buffer)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8552650	Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):412-6.	"Brogden KA, de Lucca AJ, Bland J, Elliott S."	Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica.
DRAMP18719	DDDDDDD	7	"SAAP fraction 3 (Surfactant-associated anionic peptides; Asp-rich; sheep, ruminant, mammals, animals)"	No entry found	Not found	Not found	Ovis aries	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Rich	Not found	None	Function: Antibacterial activity against Gram positive and negative bacteria. No amidation at the C-terminus	"[Ref.8552650] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MBC50=1.21 mM in Zn-saline), Streptococcus faecalis ATCC 29213 (MBC50=1.39 mM in Zn-saline);##Gram-negative bacteria: Escherichia coli ATCC 12795 (MBC50=0.64 mM in Zn-saline), Klebsiella pneumoniae ATCC 10031 (MBC50=0.62 mM in Zn-saline), Pasteurella haemolytica (MBC50=0.02 mM in Zn-saline, MBC50=8.52 mM in Test buffer; Peptide/surfactant mixture MBC50=0.01 mM in Zn-saline, MBC50=4.43 mM in Test buffer; Peptide/serum mixture MBC50=0.02 mM in Zn-saline, MBC50=4.95 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.03 mM in Zn-saline, MBC50=2.79 mM in Test buffer)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8552650	Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):412-6.	"Brogden KA, de Lucca AJ, Bland J, Elliott S."	Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica.
DRAMP18720	GADDDDD	7	"SAAP fraction 6 (Surfactant-associated anionic peptides; Asp-rich; sheep, ruminant, mammals, animals)"	No entry found	Not found	Not found	Ovis aries	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Rich	Not found	None	Function: Antibacterial activity against negative bacteria. No amidation at the C-terminus	"[Ref.8552650] Gram-negative bacterium: Pasteurella haemolytica (MBC50=0.02 mM in Zn-saline, MBC50=10.10 mM in Test buffer; Peptide/surfactant mixture MBC50=0.04 mM in Zn-saline, MBC50=5.18 mM in Test buffer; Peptide/serum mixture MBC50=0.04 mM in Zn-saline, MBC50=5.59 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.04 mM in Zn-saline, MBC50=4.75 mM in Test buffer)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	8552650	Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):412-6.	"Brogden KA, de Lucca AJ, Bland J, Elliott S."	Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica.
DRAMP18721	GWKIGKKLEHHGQNIRDGLISAGPAVFAVGQAATIYAAAK	40	"Hinnavin I (Hin I; insects, arthropods, invertebrates, animals)"	No entry found	Belongs to the Cecropins family.	Not found	Artogeia rapae (cabbage butterfly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Hinnavin 1 is heat stable; its activity is retained after 60 min incubation at 100 DC, being effective against Gram negative and/or Gram positive bacteria. Hinnavin I and lysozyme 2 showed a powerful synergistic effect on the inhibition of bacterial growth."	"[Ref.9339895] Gram-positive bacteria: Bacillus subtilis (Inhibition zone=3.0 mm), Bacillus megaterium Bm11 (Inhibition zone=5.0 mm), Bacillus thuringiensis (Inhibition zone=3.0 mm);##Gram-negative bacteria: Escherichia coli (Inhibition zone=7.0 mm), Escherichia coli D21 (Inhibition zone=7.1 mm), Enterobacter cloacae (Inhibition zone=6.0 mm);##Fungi: Candida albicans (Inhibition zone=3.0 mm), Aspergillus niger (Inhibition zone=3.0 mm)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Cell membranes	9339895	Mol Cells. 1997 Aug 31;7(4):509-13	"Bang IS, Son SY, Yoe SM."	"Hinnavin I, an antibacterial peptide from cabbage butterfly, Artogeia rapae."
DRAMP18722	AKKFGKAFVGEIM	13	MA (Magainin 2 (9-21) truncated peptide)	P11006	Belongs to truncated magainin 2.	magainins	Xenopus laevis (African clawed frog)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria.	[Ref.28178190] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=32 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28178190	Int J Mol Sci. 2017 Feb 6;18(2). pii: E339. 	"Tan T, Wu D, Li W, Zheng X, Li W, Shan A."	High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
DRAMP18723	KWKLFKKI	8	CE (Cecropin A (1	P01507	Belongs to truncated Cecropin A.	Not found	Hyalophora cecropia (Cecropia moth)	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	random coil	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.	[Ref.28178190] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=64 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28178190	Int J Mol Sci. 2017 Feb 6;18(2). pii: E339. 	"Tan T, Wu D, Li W, Zheng X, Li W, Shan A."	High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
DRAMP18724	PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAGNAK	69	"Oncorhyncin III (Oncorhyncin-3, histone-derived; fish, animals)"	P02315	Belongs to the HMGN family.	Not found	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	"Function: Oncorhyncin III has antibacterial activity against Gram-positive and Gram-negative bacteria at submicromolar concentrations. Non-histone protein that probably binds to the inner side of nucleosomal DNA, altering the association between the DNA and the nucleosome octamer. "	"[Ref.12713443] Gram-positive bacteria: Aerococcus viridans (MIC=0.06-0.12 ¦ÌM), Bacillus subtilis (MIC=0.25-0.5 ¦ÌM), Micrococcus luteus (MIC=0.12-0.25 ¦ÌM), Planococcus citerus (MIC=0.06-0.12 ¦ÌM);##Gram-negative bacteria: Aeromonas hydrophila (MIC>0.5 ¦ÌM), Aeromonas salmonicida (MIC>0.5 ¦ÌM), Escherichia coli (MIC=0.25-0.5 ¦ÌM), Listonella anguillarum (MIC=0.25-0.5 ¦ÌM)."	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	12713443	Biochem 2003; 373 (Pt 2): 621-628	"Fernandes JM., Saint N, Kemp GD, Smith VJ. "	"Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss."
DRAMP02518	KRFKKFFKKLKNSVKKRAKKFFKKPKVIGVTFPF	34	NA-CATH	No entry found	Not found	Not found	Naja atra	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	"Alpha helix, random coil"	NA-CATH has previously been shown to be random coil in water or buffer and 	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.	"[Ref.28089718] Gram-negative bacteria: Acinetobacter baumannii ATCC 9955 (MIC=10¦Ìg/ml), Acinetobacter baumannii ATCC BAA-1794 (MIC=10¦Ìg/ml), Escherichia coli ATCC 51659 (MIC=21¦Ìg/ml), K. pneumoniae ATCC 33495 (MIC=5.2¦Ìg/ml), K. pneumoniae ATCC BAA-1705 (MIC=5.2¦Ìg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=10¦Ìg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (MIC=10¦Ìg/ml)"	[Ref.28089718] 0% hemolysis at 300¦Ìg/ml against sheep red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	28089718	Dev Comp Immunol. 2017 May;70:135-144. 	"Barksdale SM, Hrifko EJ, van Hoek ML."	Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae
DRAMP03714	FLGALWNVAKSVF	13	VmCT1	I0DEB3 	Belongs to the scorpion NDBP 5 family	Not found	Vaejovis mexicanus smithi (Scorpion)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	"Alpha helix, random coil"	"the peptide showed a coiled structure in water, zwitterionic lipid vesicles (POPC and POPC:DOPE) and negatively charge lipid vesicle (POPC:POPG) the analogs tend to adopt helical structures."	None	"Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria, antifungal activity. Has hemolytic activity."	"[Ref.27912176] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=3.12 ¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=25¦Ìmol/L), Staphylococcus epidermidis ATCC 12228 (MIC=3.12¦Ìmol/L);##Gram-negative bacterium: Pseudomonas aeruginosa ATCC 27853 (MIC=0.78¦Ìmol/L), Escherichia coli D31 (MIC=3.12¦Ìmol/L), Serratia marcescens ATCC 4112 (MIC=1.56¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=25¦Ìmol/L), Micrococcus luteus A270 (MIC=1.56¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=12.5¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=6.25¦Ìmol/L), Candida parapsilosis IOC 4564 (MIC=25¦Ìmol/L), Aspergillus niger (MIC=25¦Ìmol/L), Cladosporium herbarum ATCC 26362 (MIC=50¦Ìmol/L), Cryptococcus neoformans (MIC=3.12¦Ìmol/L)"	[Ref.27912176] 10% hemolysis at 1.99¦Ìmol/L against human red blood cells.	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27912176	Eur J Med Chem. 2017 Jan 27;126:456-463. 	"Pedron CN, Torres MT, Lima JADS, Silva PI, Silva FD, Oliveira VX."	Novel designed VmCT1 analogs with increased antimicrobial activity
DRAMP03645	LVQRGRFGRFLRKIRRFRPKVTITIQGSARFG	32	fowlicidin-2	No entry found	Not found	CATHL2	Gallus gallus 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not foundn	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.	"[Ref.27698732] Gram-positive bacterium:Staphylococcus aureus ATCC 29213 (MIC=4?M);##Gram-negative bacterium:Escherichia coli ATCC 25922 (MIC=1?M), Pseudomonas aeruginosa ATCC 27853 (MIC=4?M), Salmonella typhimurium C77-31 (MIC=2?M)"	"[Ref.27698732] 15% hemolysis at 10?M,40% hemolysis at 80?M,60% hemolysis at 200?M against human red blood cells."	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	27698732	Exp Ther Med. 2016 Oct;12(4):2324-2330.	"Xing LW, Tian SX, Gao W, Yang N, Qu P, Liu D, Jiao J, Wang J, Feng XJ."	Recombinant expression and biological characterization of the antimicrobial peptide fowlicidin-2 in Pichia pastoris.
DRAMP20771	GKCSVLKKVACAAAIAGAVAACGGIDLPCVLAALKAAEGCASCFCEDHCHGVCKDLHLC	59	"Acanthaporin (parasite, amoebozoa, protozoa, protists)"	I3NI56	Not found	Not found	Acanthamoeba culbertsoni	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix	Not found	"2LRD, 2LRE resolved by NMR."	"Function: Acanthaporin is antimicrobially active against several Gram-positive and Gram-negative bacteria at pH 5.2 but is inactive at pH 7.4, reflecting a pH-dependent activity of the protein."	No MICs found in DRAMP database	No hemolysis information or data found in the reference(s) presented in this entry	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	23143413	Nat Chem Biol. 2013 Jan;9(1):37-42.	"Michalek M, S?nnichsen FD, Wechselberger R, Dingley AJ, Hung CW, Kopp A, Wienk H, Simanski M, Herbst R, Lorenzen I, Marciano-Cabral F, Gelhaus C, Gutsmann T, Tholey A, Gr?tzinger J, Leippe M."	Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba.
DRAMP20772	PPHKKKLAVYPVFLFYLFLSWFSLIV	26	"cPcAMP1/26 (ciliate, Protists)"	No entry found	Not found	Pcamp1	Paramecium caudatum	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: cPcAMP1/26 is capable of markedly killing A. hydrophila and S. aureus (p < 0.05)	"[Ref.26883426] cPcAMP1/26 is capable of markedly killing A. hydrophila and S. aureus (p < 0.05), with the bactericidal rates being 27.7%, 31.7% and 40.1% as well as 34.4%, 47.4% and 49.2%, respectively"	[Ref.26883426] cPcAMP1/26 showed little hemolytic activity towards human erythrocytes at 100 ¦Ìg/ml	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not included yet	Not found	26883426	Dev Comp Immunol. 2016 Jul;60:53-65.	"Cui P, Dong Y, Li Z, Zhang Y, Zhang S."	Identification and functional characterization of an uncharacterized antimicrobial peptide from a ciliate Paramecium caudatum.
DRAMP20776	IGGYCSWLRL	10	"HaA4 (beetles,insects,animals)"	No entry found	Not found	Not found	Harmonia axyridis (Multicolored Asian lady beetle)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria. HaA4 is proved to have more potent activity against Staphylococcus epidermidis, M. luteus, and Pseudomonas syringae."	"[Ref.23124352] Gram-negative bacteria: Escherichia coli KACC 13821 (MIC=32 microM), Klebsiella pneumoniae KACC 11402 (MIC<64 microM), Pseudomonas aeruginosa KACC 10259 (MIC<64 microM), Pseudomonas syringae KACC 10659 (MIC=2 microM)£»## Gram-positive bacteria: Staphylococcus aureus KACC 13257 (MIC<64 microM),  MR Staphylococcus aureus CCARM 3001(MIC=32 microM), Enterococcus faecalis KACC 13807 (MIC=16 microM), Enterococcus hirae KACC 16328 ( MIC=32 microM), Staphylococcus epidermidis KACC 13234 (MIC=8 microM), Micrococcus luteus KACC 10488 (MIC = 4 microM), Streptococcus pyogenes KACC 11956 (MIC=32 microM)"	"[Ref.23124352] In the hemolytic assay, HaA4 peptide evidenced no hemolytic activity against mouse red blood cells, even at high concentrations, and thus suggesting that the peptide may not be detrimental to eukaryotic cells."	Linear	Free	Amidation	None	L	[Ref.23124352] The cytotoxicity is not found in a dose dependent manner.	Not found	23124352	J Microbiol Biotechnol. 2012 Nov;22(11):1588-90.	"Kim IW, Lee JH, Park HY, Kwon YN, Yun EY, Nam SH, Kim SR, Ahn MY, Hwang JS."	"Characterization and cDNA cloning of a defensin-like peptide, harmoniasin, from Harmonia axyridis."
DRAMP20777	KRFKKFFRKLKKSVKKRAKEFFKKPRVIGVSIPF	34	Cath-BF	No entry found	Derived from three-finger toxin	Not found	Bungarus fasciatus (Banded krait)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29392557] Gram-positive bacteria: MRSA PS-2 (MIC=64 ¦Ìg/ml);##Gram-negative bacteria, MRSA PS-7 (MIC=64 ¦Ìg/ml), MRSA PS-18 (MIC=64 ¦Ìg/ml), MRSA PS-45 (MIC=64 ¦Ìg/ml), MRSA PS-46 (MIC=128 ¦Ìg/ml), MRSA PS-50 (MIC=64 ¦Ìg/ml), MRSA PS-59 (MIC=128 ¦Ìg/ml), MRSA PS-70 (MIC=32 ¦Ìg/ml), MRSA PS-84 (MIC=128 ¦Ìg/ml), MRSA PS-106 (MIC=128 ¦Ìg/ml), MRSA PS-131 (MIC=64 ¦Ìg/ml), MRSA PS-139 (MIC=64 ¦Ìg/ml), MRSA PS-162 (MIC=64 ¦Ìg/ml), MRSA PS-165 (MIC=32 ¦Ìg/ml), Staphylococcus aureus ATCC 25923 (MIC=16 ¦Ìg/ml), Staphylococcus aureus ATCC 33591 (MIC=256 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 ¦Ìg/ml), Escherichia coli ATCC 51446 (MIC=16 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=32 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=4 ¦Ìg/ml)"	"[Ref.29392557] 5% haemolysis at 1.0 ¦Ìg/ml, 5% haemolysis at 2.0 ¦Ìg/ml, 5% haemolysis at 4.0 ¦Ìg/ml, 5% haemolysis at 8.0 ¦Ìg/ml, 7% haemolysis at 16.0 ¦Ìg/ml, 9% haemolysis at 31.2 ¦Ìg/ml, 13% haemolysis at 62.5 ¦Ìg/ml, 17% haemolysis at 125.0 ¦Ìg/ml, 19% haemolysis at 250.0 ¦Ìg/ml, 23% haemolysis at 500.0 ¦Ìg/ml, 24% haemolysis at 1000.0 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.29392557] The cell viability of HUVEC at the peptide concentration of 35.5 ¦Ìg/ml, 71 ¦Ìg/ml and 113 ¦Ìg/ml  is 127%, 100% and 76%. ##The cell viability of H9c2 at the peptide concentration of 35.5, 71, and 113 ¦Ìg/ml is 132, 100, and 80%."	Not found	29392557	J Microbiol. 2018 Feb;56(2):128-137.	"Tajbakhsh M, Karimi A, Tohidpour A, Abbasi N, Fallah F, Akhavan MM."	The antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus.
DRAMP20778	FFFLSRIF	8	"Temporin-SHf (frogs,amphibians,animals)"	No entry found	Belongs to the Temporin family	Not found	Pelophylax saharica(Sahara frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	"Once bound parallel to the microbial membrane surface, it folds into a non-amphipathic hydrophobic "	None	"Function: Antibacterial activity against the Gram-negative bacteria (Escherichia coli ATCC 25922, Escherichia coli ATCC 35218, Escherichia coli D21, Escherichia coli ML-35p, Pseudomonas aeruginosa ATCC 27853) and Gram-positive bacteria (Staphylococcus aureus ATCC 25923, E. faecalis ATCC 29212, Bacillus megaterium. Antifungal activity)"	[Ref.20308076] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=25 ¦ÌM); Escherichia coli ATCC 35218(MIC>200 ¦ÌM); Escherichia coli D21(MIC=100 ¦ÌM); Escherichia coli ML-35p(MIC=30 ¦ÌM); Pseudomonas aeruginosa ATCC 27853(MIC>200 ¦ÌM);## Gram-positive bacteria: Staphylococcus aureus ATCC 25923(MIC=12.5 ¦ÌM); E. faecalis ATCC 29212(MIC=50 ¦ÌM); Bacillus megaterium(MIC=3 ¦ÌM);## Yeasts: Candida albicans ATCC 90028(MIC=50 ¦ÌM); C. parapsilosis ATCC 22019(MIC=50 ¦ÌM); S. cerevisiae(MIC=12.5 ¦ÌM);## Fungus(MIC>200 ¦ÌM)	"[Ref.20308076] Temporin-SHf is not cytotoxic against human erythrocytes (LC50 = 200 ¦Ìm), with a hemolytic activity detected only at peptide concentration far above the MIC values determined for the sensitive strains (3¨C50 ¦Ìm) "	Linear	Free	Amidation	None	L	[Ref.20308076] No cytotoxicity information found	Not found	20308076	J Biol Chem. 2010 May 28;285(22):16880-92. 	"Abbassi F, Lequin O, Piesse C, Goasdou"	"Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide."
DRAMP20779	GMWSKILGHLIR	12	"Halictine 1 (bees,insects,animals)"	No entry found	Not found	Not found	Halictus sexcinctus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Exhibits potent antimicrobial activity against the Gram-positive and Gram-negative bacteria as well as noticeable hemolytic activity. 	"[Ref.20198492] Gram-negative bacteria: Escherichia coli(MIC=3.8 ¦ÌM), Pseudomonas aeruginosa(MIC=45.0 ¦ÌM);## Gram-positive bacteria: Bacillus subtilis(MIC=0.8 ¦ÌM), Staphylococcus aureus(MIC=7.7 ¦ÌM)"	[Ref.20198492]  LC50=82¦ÌM against rat red blood cells	Linear	Free	Amidation	None	L	[Ref.20198492] No cytotoxicity information found	Not found	20198492	Amino Acids. 2010 Aug;39(3):763-75. 	"Monincov¨¢ L, Budes¨ªnsk¦Ì M, Slaninov¨¢ J, Hovorka O, Cvacka J, Voburka Z, Fuc¨ªk V, Borovickov¨¢ L, Bedn¨¢rov¨¢ L, Straka J, Cerovsk¦Ì V."	Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs.
DRAMP20780	GKWMSLLKHILK	12	"Halictine 2 (bees,insects,animals)"	No entry found	Not found	Not found	Halictus sexcinctus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Exhibits potent antimicrobial activity against the Gram-positive and Gram-negative bacteria as well as noticeable hemolytic activity. 	"[Ref.20198492] Gram-negative bacteria: Escherichia coli(MIC=2.5¦ÌM), Pseudomonas aeruginosa(MIC=42.1);## Gram-positive bacteria: Bacillus subtilis(MIC=1.0¦ÌM), Staphylococcus aureus(MIC=8.1¦ÌM)"	[Ref.20198492]  LC50=78.1¦ÌM against rat red blood cells	Linear	Free	Amidation	None	L	[Ref.20198492] No cytotoxicity information found	Not found	20198492	Amino Acids. 2010 Aug;39(3):763-75. 	"Monincov¨¢ L, Budes¨ªnsk¦Ì M, Slaninov¨¢ J, Hovorka O, Cvacka J, Voburka Z, Fuc¨ªk V, Borovickov¨¢ L, Bedn¨¢rov¨¢ L, Straka J, Cerovsk¦Ì V."	Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs.
DRAMP20781	LNWGAILKHIIK	12	"Panurgine 1(bees,insects,animals)"	C0HL84	Not found	Not found	Panurgus calcaratus(communal bee)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria, antifungal activity, and low hemolytic activity against human erythrocytes. "	"[Ref.23483218] Gram-negative bacteria: Escherichia coli(MIC=3.7¦ÌM), Pseudomonas aeruginosa(MIC=51.7¦ÌM) ;## Gram-positive bacteria: Micrococcus luteus(MIC=1.5¦ÌM), Bacillus subtilis(MIC=1.3¦ÌM), Staphylococcus aureus(MIC=10.6¦ÌM) ;## Yeast: Candida albicans(MIC=7.3¦ÌM)"	[Ref.23483218] LC50=119¦ÌM against rat red blood cells	Linear	Free	Amidation	None	L	[Ref.23483218] No cytotoxicity information found	Not found	23483218	Amino Acids. 2013 Jul;45(1):143-57. 	"?ujov¨¢ S, Slaninov¨¢ J, Monincov¨¢ L, Fu¦Ì¨ªk V, Bedn¨¢rov¨¢ L, ¦Ìtokrov¨¢ J, Hovorka O, Voburka Z, Straka J, ¦Ìe¦Ìovsk¦Ì V."	"Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae)."
DRAMP20782	FLSGILKLAFKIPSVLCAVLKNC	23	"Pleurain-D1  (Frogs,amphibians,animals)"	"B5L1C5, B5L1D1, B5L1C3, B5L1C9, B5L1C2, B5L1D4"	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Nidirana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Not found	Not found	None	"Function: Antimicrobial activity  against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.19028675] Gram-negative bacteria: Escherichia coli (MIC=25 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ¦Ìg/ml), Bacillus subtilis (MIC=50 ¦Ìg/ml);##Yeast: Candida albicans(MIC=25 ¦Ìg/ml)"	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	None	L	[Ref.19028675] No cytotoxicity information found	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP20783	GLLDSVKEGLKKVAGQLLDTLKCKISGCTPA	31	"Pleurain-M1  (Frogs,amphibians,animals)"	B5L1L3	Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.	Not found	Nidirana pleuraden (Yunnan pond frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	"Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi."	"[Ref.19028675] Gram-negative bacteria: Escherichia coli (MIC=6.3 ¦Ìg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ¦Ìg/ml), Bacillus subtilis (MIC=25 ¦Ìg/ml);##Yeast: Candida albicans(MIC=12.5 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Free	None	L	[Ref.19028675] No cytotoxicity information found	Not found	19028675	Mol Cell Proteomics. 2009 Mar;8(3):571-83.	"Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R."	Antioxidant peptidomics reveals novel skin antioxidant system.
DRAMP20784	FLKGCWTKWYSLKPKCPF	18	Megin 1	No entry found	Not found	Not found	Amphibian skin	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	The peptide contains an intra-molecular di-sulfide bridge	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27114317] Gram-negative bacteria: Escherichia coli (ATCC 25922)(MIC=25¦Ìg/mL);B. dysenteriae(MIC=3¦Ìg/mL);##Gram-positive bacteria:Staphylococcus aureus (ATCC 2592)(MIC=6.25¦Ìg/mL);Bacillus subtilis (ATCC 6633)(MIC=3¦Ìg/mL) ;##Fungi:C.albicans (ATCC 2002)(MIC=50¦Ìg/mL)	[Ref.27114317] Human red blood cells: 2.3% hemolysis at 25¦Ìg/ml; 5.6% hemolysis at 50¦Ìg/ml; 18.7% hemolysis at 100¦Ìg/ml; 29.5% hemolysis at 200¦Ìg/ml. Rabbit red blood cells :3.1% hemolysis at 25¦Ìg/ml; 7.3% hemolysis at 50¦Ìg/ml; 20.5% hemolysis at 100¦Ìg/ml; 32.9% hemolysis at 200¦Ìg/ml	Cyclic	Free	Amidation	Disulfide bond between Cys5 and Cys16	L	No cytotoxicity information found	Not found	27114317	Chin J Nat Med. 2016 Apr;14(4):294-298. 	"Yang HL, Shen ZQ, Liu X, Kong Y."	Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor.
DRAMP20785	FFVLKFLLKWAGKVGLEHLACKFKNWC	27	Megin 2	No entry found	Not found	Not found	Amphibian skin	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	The peptide contains an intra-molecular di-sulfide bridge	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27114317] Gram-negative bacteria: Escherichia coli (ATCC 25922)(MIC=6.25¦Ìg/mL);B. dysenteriae(MIC=1.5¦Ìg/mL);##Gram-positive bacteria:Staphylococcus aureus (ATCC 2592)(MIC=12.5¦Ìg/mL);Bacillus subtilis (ATCC 6633)(MIC=1.5¦Ìg/mL) ;##Fungi:C.albicans (ATCC 2002)(MIC=12.5¦Ìg/mL)	[Ref.27114317] Human red blood cells: 3.9% hemolysis at 25¦Ìg/ml; 13.7% hemolysis at 50¦Ìg/ml; 27.7% hemolysis at 100¦Ìg/ml; 45.3% hemolysis at 200¦Ìg/ml;Rabbit red blood cells: 5.6% hemolysis at 25¦Ìg/ml; 15.2% hemolysis at 50¦Ìg/ml; 36.2% hemolysis at 100¦Ìg/ml; 50.3% hemolysis at 200 ¦Ìg/ml	Cyclic	Free	Free	Disulfide bond between Cys21 and Cys27.	L	No cytotoxicity information found	Not found	27114317	Chin J Nat Med. 2016 Apr;14(4):294-298. 	"Yang HL, Shen ZQ, Liu X, Kong Y."	Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor.
DRAMP20786	RRLRPRRPRLPRPRPRPRPRPR	22	mini-ChBac7.5N alpha	No entry found	Not found	Not found	Capra hircus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27795854] Gram-negative bacteria: E.coli (ML35p)(MIC=0.3 ¡À 0.1¦ÌM without NaCl;MIC=1.5 ¡À 0.2¦ÌM 100 mM NaCl;MIC=1¦ÌM Broth microdilution assay);E.coli (ATCC 25922)(MIC=0.6 ¡À 0.1¦ÌM without NaCl;MIC=0.9 ¡À 0.2¦ÌM 100 mM NaCl;MIC=2¦ÌM Broth microdilution assay);E.coli (M17)(MIC=0.5 ¡À 0.1¦ÌM without NaCl;MIC=0.8 ¡À 0.1¦ÌM 100 mM NaCl;MIC=2¦ÌM Broth microdilution assay);Pseudomonas aeruginosa (ATCC 27853)(MIC=1.1 ¡À 0.4¦ÌM without NaCl;MIC=3.7 ¡À 1.2¦ÌM 100 mM NaCl;MIC=2¦ÌM Broth microdilution assay);Pseudomonas aeruginosa clinical isolate(MIC=2¦ÌM Broth microdilution assay);Klebsiella spp. clinical isolate(MIC=4¦ÌM Broth microdilution assay);Acinetobacter baumannii clinical isolate(MIC=2¦ÌM Broth microdilution assay);##Gram-positive bacteria:Listeria monocytogenes (EGD)(MIC=0.2 ¡À 0.1¦ÌM without NaCl;MIC=1.0 ¡À 0.2¦ÌM 100 mM NaCl;MIC=2¦ÌM Broth microdilution assay);Micrococcus luteus CIP A270(MIC=1¦ÌM Broth microdilution assay);Staphylococcus aureus (710A)(MIC=0.7 ¡À 0.2¦ÌM without NaCl;MIC> 50¦ÌM 100 mM NaCl;MIC>64¦ÌM Broth microdilution assay);Staphylococcus aureus (ATCC 25923)(MIC>64¦ÌM Broth microdilution assay);MRSA (ATCC 33591)(MIC=0.7 ¡À 0.2¦ÌM without NaCl;MIC> 50¦ÌM 100 mM NaCl;MIC>64¦ÌM Broth microdilution assay);Staphylococcus intermedius clin. isolate(MIC>64¦ÌM Broth microdilution assay);##Fungi:Candida albicans (820)(MIC=0.3 ¡À 0.1¦ÌM without NaCl;MIC> 50¦ÌM 100 mM NaCl;MIC=64¦ÌM Broth microdilution assay);Candida parapsilosis clinical isolate(MIC>64¦ÌM Broth microdilution assay)	[Ref.27818338] No hemolytic activity 	Linear	Free	Free	None	L	"[Ref.27795854] The cytotoxicity values of the experimental samples are not significantly different from the values of the control samples over the entire range of concentrations:1-30 ¦ÌM against various types of cultured human cells: namly, reythroleukemi"	Not found	27795854	Acta Naturae. 2016 Jul-Sep;8(3):136-146.	"Shamova OV, Orlov DS, Zharkova MS, Balandin SV, Yamschikova EV, Knappe D, Hoffmann R, Kokryakov VN, Ovchinnikova TV."	Minibactenecins ChBac7.N
DRAMP20787	RRLRPRRPRLPRPRPRPRPRP	21	mini-ChBac7.5N beta	No entry found	Not found	Not found	Capra hircus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27795854] Gram-negative bacteria:E.coli (ML35p)(MIC=0.3 ¡À 0.1¦ÌM without NaCl;MIC=1.4 ¡À 0.2¦ÌM 100 mM NaCl;MIC=1¦ÌM Broth microdilution assay);E.coli (ATCC 25922)(MIC=0.5 ¡À 0.2¦ÌM without NaCl;MIC=0.8 ¡À 0.2¦ÌM 100 mM NaCl;MIC=2¦ÌM Broth microdilution assay);E.coli (M17)(MIC=0.5 ¡À 0.1¦ÌM without NaCl;MIC=0.9 ¡À 0.2¦ÌM 100 mM NaCl;MIC=1¦ÌM Broth microdilution assay);Pseudomonas aeruginosa (ATCC 27853)(MIC=1.0 ¡À 0.3¦ÌM without NaCl;MIC=3.2 ¡À 0.8¦ÌM 100 mM NaCl;MIC=2¦ÌM Broth microdilution assay);Pseudomonas aeruginosa clinical isolate(MIC=2¦ÌM Broth microdilution assay);Klebsiella spp. clinical isolate(MIC=4¦ÌM Broth microdilution assay);Acinetobacter baumannii clinical isolate(MIC=4¦ÌM Broth microdilution assay);##Gram-positive bacteria:Listeria monocytogenes (EGD)(MIC=0.2 ¡À 0.1¦ÌM without NaCl;MIC=0.9 ¡À 0.2¦ÌM 100 mM NaCl;MIC=2¦ÌM Broth microdilution assay);Micrococcus luteus CIP A270(MIC=1¦ÌM Broth microdilution assay);Staphylococcus aureus (710A)(MIC=0.6 ¡À 0.1¦ÌM without NaCl;MIC> 50¦ÌM 100 mM NaCl;MIC>64¦ÌM Broth microdilution assay);Staphylococcus aureus (ATCC 25923)(MIC>64¦ÌM Broth microdilution assay);MRSA (ATCC 33591)(MIC=0.5 ¡À 0.1¦ÌM without NaCl;MIC> 50¦ÌM 100 mM NaCl;MIC>64¦ÌM Broth microdilution assay);Staphylococcus intermedius clin. isolate(MIC>64¦ÌM Broth microdilution assay);##Fungi:Candida albicans (820)(MIC=0.3 ¡À 0.1¦ÌM without NaCl;MIC> 50¦ÌM 100 mM NaCl;MIC=64¦ÌM Broth microdilution assay);Candida parapsilosis clinical isolate(MIC>64¦ÌM Broth microdilution assay)	[Ref.27818338] No hemolytic activity 	Linear	Free	Free	None	L	"[Ref.27795854] The cytotoxicity values of the experimental samples are not significantly different from the values of the control samples over the entire range of concentrations:1-30 ¦ÌM against various types of cultured human cells: namly, reythroleukemi"	Not found	27795854	Acta Naturae. 2016 Jul-Sep;8(3):136-146.	"Shamova OV, Orlov DS, Zharkova MS, Balandin SV, Yamschikova EV, Knappe D, Hoffmann R, Kokryakov VN, Ovchinnikova TV."	Minibactenecins ChBac7.N
DRAMP20790	KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKALG	36	"Cecropin B (Insects, arthropods, invertebrates, animals)"	P01508	Belongs to the cecropin family.	Not found	Hyalophora cecropia (Cecropia moth)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antibacterial activity against several Gram-positive and Gram-negative bacteria.	"[Ref.7019715] Gram-positive bacteria: Bacillus megaterium Bm11 (Inhibition zone=10.0 mm), Bacillus subtilis (Inhibition zone=7.2 mm);##Gram-negative bacteria: Escherichia coli K12 D31 (Inhibition zone=12.5 mm), Serratia marcescens Db1108 (Inhibition zone=7.2 mm), Pseudomonas aeruginosa OT97 (Inhibition zone=9.7 mm), Xenorhabdus nematophilus Xn21 (Inhibition zone=10.0 mm)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation (Leu35) PMID:3857578	None	L	[Ref.7019715] No cytotoxicity information found	Not found	7019715	Nature. 1981 Jul 16;292(5820):246-8.	"Steiner H, Hultmark D, Engstr?m A, Bennich H, Boman HG."	Sequence and specificity of two antibacterial proteins involved in insect immunity
DRAMP20792	GLFVGVLAKVAAHVVPAIAEHF	22	"Maculatin 1.1 (Frog, amphibians, animals)"	P82066	Not found	Not found	Litoria genimaculata (Green-eyed tree frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Helix	Not found	2MMJ resolved by NMR	"Function: Maculatin-1.1 shows significant antibacterial activity against Gram-positive bacteria, less against Gram-negative bacteria. Maculatin-1.1.1 is inactive.
Tissue specificity: Expressed by the skin dorsal glands."	"[Ref.9620615] Gram positive bacteria: Bacillus cereus (MIC=50 ¦Ìg/ml), Leuconostoc lactis (MIC=25 ¦Ìg/ml), Listeria innocua (MIC=100 ¦Ìg/ml), Micrococcus luteus (MIC=12.5 ¦Ìg/ml), Staphylococcus aureus (MIC=6-12.5 ¦Ìg/ml), Staphylococcus epidermidis (MIC=12.5 ¦Ìg/ml), Streptococcus faecalis (MIC=25 ¦Ìg/ml), Streptococcus uberis (MIC=3 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli (MIC=100 ¦Ìg/ml), Pasteurella multocida (MIC=100 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	None	L	[Ref.9620615] No cytotoxicity information found	Not found	9620615	J. Pept. Sci. 1998 Apr; 4(2): 111-115. 	"Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC."	The maculatin peptide from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
DRAMP20797	GVIDAAKKVVNVLKNLF	17	"Uperin 3.6 (Toad, amphibians, animals)"	P82043	Belongs to the frog skin active peptide (FSAP) family. Uperin subfamily.	Not found	Uperoleia mjobergii (Australian toadlet)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix 	Not found	None	"Function: Antibacterial activity against B.cereus, L.lactis, L.innocua, M.luteus, S.aureus, S.epidermidis and S.uberis.
Tissue specificity: Expressed by the skin dorsal glands.
Mass spectrometry: Molecular mass is 1826 Da from positions 1 - 17. Determined by FAB."	"[Ref.10461748] Gram positive bacteria: Bacillus cereus (MIC=25 ¦Ìg/ml), Leuconostoc lactis  (MIC=3 ¦Ìg/ml), Listeria innocua (MIC=50 ¦Ìg/ml), Micrococcus luteus (MIC=50 ¦Ìg/ml), Staphylococcus aureus (MIC=25 ¦Ìg/ml), Staphylococcus epidermidis (MIC=12 ¦Ìg/ml), Streptococcus uberis (MIC=12 ¦Ìg/ml);##Gram-negative bacterium: Pasteurella haemolytica (MIC=25 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear	Free	Amidation	None	L	[Ref.10461748] No cytotoxicity information found	Not found	10461748	J Pept Res. 1999 Aug;54(2):137-45.	"Chia BC, Carver JA, Mulhern TD, Bowie JH"	"The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii."
DRAMP20798	QGVRNSQSCRRNKGICVPIRCPGSMRQIGTCLGAQVKCCRRK	42	"Lingual antimicrobial peptide (LAP, beta defensin, cattle, ruminant, animals)"	Q28880	Belongs to the beta-defensin family. LAP/TAP subfamily.	LAP	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Bridge 	Not found	None	"Function: Shows a broad spectrum of antibacterial and antifungal activities.
Tissue specificity: In many of the exposed epithelial surfaces including conjunctivae, bronchi, colon, urinary tract and trachea.
Developmental stage: Not found in fetus."	"[Ref.7886453] Gram-positive bacterium: Staphylococcus aureus 29213 (MIC=63-125 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli D31 (MIC=16-32 ¦Ìg/ml), Pseudomonas aeruginosa 27853  (MIC=63-125 ¦Ìg/ml);##Fungi: Candida albicans 14053  (MIC=32-63 ¦Ìg/ml), Candida tropicalis 13803 (MIC=16-32 ¦Ìg/ml)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Free	"Disulfide bonds between Cys9 and Cys38, Cys16 and Cys31, Cys21 and Cys39."	L	[Ref.7886453] No cytotoxicity information found	Not found	7886453	Science. 1995 Mar 17; 267(5204):1645-1648	"Schonwetter BS., Stolzenberg ED., Zasloff MA."	Epithelial antibiotics induced at sites of inflammation.
DRAMP20799	GCWSTVLGGLKKFAKGGLEAIVNPK	25	"XT-2 (frog, amphibians, animals)"	No entry found	Belongs to the Pipidae family.	Not found	"Xenopus tropicalis (Diploid clawed frog, Africa)"	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria (Escherichia coli).	[Ref.11738090] Gram-negative bacteria: Escherichia coli (MIC=8¦ÌM).	[Ref.11738090] HC50 is not determined against human red blood cells.	Linear	Free	Free	None	L	[Ref.11738090] No cytotoxicity information found	Not found	11738090	Biochim Biophys Acta 2001 Nov 26;1550(1):81-9.	"Ali MF, Soto A, Knoop FC, Conlon JM."	"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)."
DRAMP20800	KKKKPLFGLFFGLF	14	the K4 peptide (synthetic; Phe-rich >25%)	No entry found	Not found	Not found	the APD database-aided design.	"Antimicrobial, Antibacterial, Anti-Gram-"	Not found	Alpha helix	Not found	None	"Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Have Hemolytic activity against rabbit erythrocytes. Have Cytotoxicity activity on CHO-K1 cells, the peptide is slightly cytotoxic at 160 "	"[Ref.19573572] Gram-negative bacteria: Escherichia coli (MIC=40-80 ¦Ìg/ml or 24-48 ¦ÌM), Vibrio alginolyticus (MIC=10-20 ¦Ìg/ml or 6-12 ¦ÌM), Vibrio harveyi (MIC=5-10 ¦Ìg/ml or 3-6 ¦ÌM)."	[Ref.19573572] No significant hemolytic activity is observed at 10 and 40 ¦Ìg/ml. Slight hemolysis (6.65%) is shown at 160 ¦Ìg/ml.	Linear	Free	Free	None	L	"[Ref.19573572] The cell viability of CHO-K1 cells is 127%, 123%,78% and 10% at peptide concentrations of 10 ¦Ìg/ml, 40 ¦Ìg/ml, 160 ¦Ìg/ml and 640 ¦Ìg/ml"	Not found	19573572	Peptides. 2009 Sep;30(9):1608-12	"Duval E, Zatylny C, Laurencin M, Baudy-Floc'h M, Henry J."	KKKKPLFGLFFGLF: a cationic peptide designed to exert antibacterial activity
DRAMP20801	GFGCPNNYQCHRHCKSIPGRCGGYCGGWHRLPCTCYRC	38	"Mussel Defensin MGD-1 (Mediterranean mussel defensin 1; mollusca/molluscs/mollusks, invertebrates, animals)"	P80571	Belongs to the invertebrate defensin family. Type 2 subfamily.	FH3	Mytilus galloprovincialis (Mediterranean mussel)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Combine Helix and Beta structure	"The signature of MGD-1 is that of the arthropod defensins which range in length from 34 to 51 amino acid residues with 6 conserved cysteines engaged in three intramolecular disulfide bridges. They are characterized by the presence of a flexible amino-terminal loop, a central amphipathic "	1FJN resolved by NMR	Function: Active against both Gram-positive and Gram-negative bacteria but is not cytotoxic towards human erythrocytes or protozoa.	"[Ref.8925841] Gram-positive bacteria: Micrococcus luteus (MIC=0.08 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli (MIC=6.4 ¦Ìg/ml), Vibrio alginolyticus (MIC=6.4 ¦Ìg/ml), Vibrio splendidus (MIC=1.6 ¦Ìg/ml), Vibrio P1 (MIC=6.4 ¦Ìg/ml)."	[Ref.8925841] The plasma is capable of causing 20% of the total hemolysis. 	Cyclic	Free	Amidation	"Disulfide bonds between Cys4 and Cys25, Cys10 and Cys33, Cys14 and Cys35, Cys21 and Cys38.  Hydroxylation of Trp28 (3hydroxytryptophan)"	L	"[Ref.8925841] The protozoan P. marinus is not killed by pure peptide, even at a concentration of 16 ¦Ìg/ml."	Cell membranes	8925841	Eur J Biochem. 1996 Aug 15;240(1):302-6.	"Hubert F, Noel T, Roch P. "	A member of the arthropod defensin family from edible Mediterranean mussels (Mytilus galloprovincialis)
DRAMP20802	GLGSVLGKALKIGANLL	17	"CPF-AM1 (caerulein precursor fragment-AM1, frogs, amphibians, animals)"	No entry found	Belongs to the CPF family.	Not found	"Xenopus amieti (skin secretions, Africa)"	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.20226221] Gram-positive bacteria: Staphylococcus aureus (MIC>200¦ÌM) ;##Gram-negative bacteria: Escherichia coli (MIC>200¦ÌM).	[Ref.20226221] LC50>200¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.20226221] No cytotoxicity information found	Cell membranes	20226221	Peptides. 2010 Jun;31(6):989-94. 	"Conlon JM, Al-Ghaferi N, Ahmed E, Meetani MA, Leprince J, Nielsen PF. "	"Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae)."
DRAMP20803	FFRNLWKGAKAAFRAGHAAWRA	22	moronecidin-like peptide	No entry found	Not found	Not found	Hippocampus comes 	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix 	The peptide is Schiffer	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria; antifungal activity.	"[Ref.30039186] Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC=3.12 ¦Ìg/ml),Staphylococcus epidermidis ATCC 1435 (MIC=1.56 ¦Ìg/ml),Staphylococcus aureus MRSA (MIC=3.12 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC10662 (MIC=50 ¦Ìg/ml),Acinetobacter baumannii clinical isolate (MIC=6.25 ¦Ìg/ml);##Fungi:Candida albicans clinical isolate (MIC=6.25 ¦Ìg/ml), Candida tropicalis clinical isolate (MIC=6.25 ¦Ìg/ml)"	"[Ref.30039186] 50% hemolysis at 87.5¦Ìg/ml,25% hemolysis at 50¦Ìg/ml,60% hemolysis at 100¦Ìg/ml against human red cells"	Linear	Free	Amidation	None	L	[Ref.30039186] No cytotoxicity information found	Not found	30039186	Mar Biotechnol (NY). 2018 Dec;20(6):718-728.	"Mohammadi M, Taheri B, Momenzadeh N, Salarinia R, Nabipour I, Farshadzadeh Z, Bargahi A."	Identification and Characterization of Novel Antimicrobial Peptide from Hippocampus comes by In Silico and Experimental Studies
DRAMP20804	DLRDSWKVIGSDKK	14	AI-hemocidins 2 (Hb-1  truncated peptide)	No entry found	Belongs to truncated Hb-1 	Not found	Arca inflata	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,random coil"	"Peptides displayed random coil conformations in PBS, the spectra of AI-hemocidin 2 featured an "	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria.	"[Ref.28661457] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=45.54 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=91.08 ¦ÌM), Pseudomonas aeruginosa clinical isolate (MIC=91.08 ¦ÌM);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=22.77 ¦ÌM), Bacillus subtilis ATCC 6633 (MIC=182.16 ¦ÌM)."	[Ref.28661457] 10.27 ¡À 0.42% hemolysis at 500 ¦Ìg/mL against murine red blood cells.	Linear	Free	Free	None	L	[Ref.28661457] The cell viability of HEK293 at the peptide concentration of 250 ¦Ìg/ml is 88.18¡À9.48%. IC50 > 1000 ¦Ìg/ml against HEK293 cells.	Not found	28661457	Mar Drugs. 2017 Jun 29;15(7). 	"Li C, Zhu J, Wang Y, Chen Y, Song L, Zheng W, Li J, Yu R."	"Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflata"
DRAMP20805	FSTKTRNWFSEHFKKVKEKLKDTFA	25	Apo5 APOC164-88 	No entry found	Not found	Not found	American alligator	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,beta-sheet,beta-turn,random coil"	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.27542832] Gram-positive bacteria:Staphylococcus aureus ATCC BAA-1718 (EC50=4.96¦Ìg/ml), Staphylococcus aureus ATCC 33592 (EC50=0.0680¦Ìg/ml);##Gram-negative bacteria:Escherichia coli ATCC 4157 (EC50=19.7¦Ìg/ml), Escherichia coli ATCC 51659 (EC50=13.9¦Ìg/ml), Pseudomonas aeruginosa PAO1 (EC50=0.0878¦Ìg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (EC50=0.467¦Ìg/ml), Acinetobacter baumannii ATCC 9955 (EC50=0.644¦Ìg/ml), Acinetobacter baumannii ATCC BAA-1794 (EC50=0.234¦Ìg/ml)"	[Ref.27542832] Not hemolytic to sheep red blood cells.	Linear	Free	Free	None	L	"[Ref.27542832] The cell proliferation of A549 human lung epithelial cells is 175%, 170%, 145%, 173% and 120% at peptide concentrations of 1 ¦Ìg/ml, 10 ¦Ìg/ml, 25 ¦Ìg/ml, 50 ¦Ìg/ml, 100 ¦Ìg/ml"	Not found	27542832	BMC Microbiol. 2016 Aug 19;16(1):189. 	"Barksdale SM, Hrifko EJ, Chung EM, van Hoek ML."	Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii
DRAMP20806	KTRNWFSEHFKKVKEKLKDTFA	22	Apo6 APOC167-88	No entry found	Not found	Not found	American alligator	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,beta-sheet,beta-turn,random coil"	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.27542832] Gram-positive bacteria:Staphylococcus aureus ATCC BAA-1718 (EC50=2.31¦Ìg/ml), Staphylococcus aureus ATCC 33592 (EC50=0.883¦Ìg/ml);##Gram-negative bacteria:Escherichia coli ATCC 4157 (EC50=3.85¦Ìg/ml), Escherichia coli ATCC 51659 (EC50=9.07¦Ìg/ml), Pseudomonas aeruginosa PAO1 (EC50=1.17¦Ìg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (EC50=0.130¦Ìg/ml), Acinetobacter baumannii ATCC 9955 (EC50=0.233¦Ìg/ml), Acinetobacter baumannii ATCC BAA-1794 (EC50=0.126¦Ìg/ml)"	[Ref.27542832] Not hemolytic to sheep red blood cells.	Linear	Free	Free	None	L	"[Ref.27542832] The cell proliferation of A549 human lung epithelial cells is 190%, 167%, 150%, 135% and 144% at peptide concentrations of 1 ¦Ìg/ml, 10 ¦Ìg/ml, 25 ¦Ìg/ml, 50 ¦Ìg/ml, 100 ¦Ìg/ml"	Not found	27542832	BMC Microbiol. 2016 Aug 19;16(1):189. 	"Barksdale SM, Hrifko EJ, Chung EM, van Hoek ML."	Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii
DRAMP20807	PPPVIKFNRPFLMWIVERDTRSILFMGKIVNPKAP	35	A1P394-428	No entry found	Not found	Not found	American alligator	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,beta-sheet,beta-turn,random coil"	A1P is primarily random coil with two anti-parallel 	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.27542832] Gram-positive bacteria:Staphylococcus aureus ATCC BAA-1718 (EC50=36.5¦Ìg/ml), Staphylococcus aureus ATCC 33592 (EC50=2.68¦Ìg/ml);##Gram-negative bacteria:Escherichia coli ATCC 4157 (EC50=9.2¦Ìg/ml), Escherichia coli ATCC 51659 (EC50=2.51¦Ìg/ml), Pseudomonas aeruginosa PAO1 (EC50=38.6¦Ìg/ml),  Acinetobacter baumannii ATCC 9955 (EC50=24.0¦Ìg/ml), Acinetobacter baumannii ATCC BAA-1794 (EC50=2.36¦Ìg/ml)"	[Ref.27542832] Not hemolytic to sheep red blood cells.	Linear	Free	Free	None	L	"[Ref.27542832] The cell proliferation of A549 human lung epithelial cells is 170%, 180%, 182%, 180% and 180% at peptide concentrations of 1 ¦Ìg/ml, 10 ¦Ìg/ml, 25 ¦Ìg/ml, 50 ¦Ìg/ml, 100 ¦Ìg/ml"	Not found	27542832	BMC Microbiol. 2016 Aug 19;16(1):189. 	"Barksdale SM, Hrifko EJ, Chung EM, van Hoek ML."	Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii
DRAMP20808	RRLRKKTRKRLKKIGKVLKWI	21	RI21 (PMAP-36 peptide derivative)	No entry found	Derived from PMAP-36	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	"Function: Antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and Fungi.."	"[Ref.27251456] Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=4 ¦ÌM, MBC=4 ¦ÌM), Staphylococcus aureus 25923 (MIC=4 ¦ÌM, MBC=4 ¦ÌM), Staphylococcus epidermidis 12228 (MIC=4 ¦ÌM, MBC=8 ¦ÌM), Bacillus subtilis 63501 (MIC=1 ¦ÌM, MBC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=2 ¦ÌM, MBC=8 ¦ÌM), Escherichia coli EC183 (MIC=1 ¦ÌM, MBC=2 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM, MBC=2 ¦ÌM), Salmonella typhimurium C77-31 (MIC=1 ¦ÌM, MBC=2 ¦ÌM);##Fungi: Candida albicans 2.2086 (MIC=8 ¦ÌM, MFC=16 ¦ÌM), Candida albicans CA276 (MIC=8 ¦ÌM, MFC=32 ¦ÌM), Candida tropicalis 2.1975 (MIC=1 ¦ÌM, MFC=2 ¦ÌM), Candida krusei 2.1857 (MIC=2 ¦ÌM, MFC=4 ¦ÌM)."	"[Ref.27251456] 5% hemolysis at 32 ¦ÌM,  MHC=32 ¦ÌM against human red blood cells."	Linear	Free	Amidation	None	L	[Ref.27251456] No cytotoxicity information found	Not found	27251456	Sci Rep. 2016 Jun 2;6:27258. 	"Lyu Y, Yang Y, Lyu X, Dong N, Shan A."	"Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida."
DRAMP20809	RKKTRKRLKKIGKVLKWI	18	RI18 (PMAP-36 peptide derivative)	No entry found	Derived from PMAP-36	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	"Function: Antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and Fungi.."	"[Ref.27251456] Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=4 ¦ÌM, MBC=4 ¦ÌM), Staphylococcus aureus 25923 (MIC=8 ¦ÌM, MBC=8 ¦ÌM), Staphylococcus epidermidis 12228 (MIC=4 ¦ÌM, MBC=16 ¦ÌM), Bacillus subtilis 63501 (MIC=1 ¦ÌM, MBC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=2 ¦ÌM, MBC=4 ¦ÌM), Escherichia coli EC183 (MIC=1 ¦ÌM, MBC=2 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM, MBC=4 ¦ÌM), Salmonella typhimurium C77-31 (MIC=2 ¦ÌM, MBC=4 ¦ÌM);##Fungi: Candida albicans 2.2086 (MIC=16 ¦ÌM, MFC=32 ¦ÌM), Candida albicans CA276 (MIC=8 ¦ÌM, MFC=16 ¦ÌM), Candida tropicalis 2.1975 (MIC=2 ¦ÌM, MFC=4 ¦ÌM), Candida krusei 2.1857 (MIC=4 ¦ÌM, MFC=8 ¦ÌM)."	"[Ref.27251456] 5% hemolysis at 128 ¦ÌM, MHC=128 ¦ÌM against human red blood cells."	Linear	Free	Amidation	None	L	[Ref.27251456] No cytotoxicity information found	Not found	27251456	Sci Rep. 2016 Jun 2;6:27258. 	"Lyu Y, Yang Y, Lyu X, Dong N, Shan A."	"Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida."
DRAMP20810	TRKRLKKIGKVLKWI	15	TI15 (PMAP-36 peptide derivative)	No entry found	Derived from PMAP-36	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	"Function: Antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and Fungi.."	"[Ref.27251456] Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=32 ¦ÌM, MBC=128 ¦ÌM), Staphylococcus aureus 25923 (MIC=32 ¦ÌM, MBC=128 ¦ÌM), Staphylococcus epidermidis 12228 (MIC=32 ¦ÌM, MBC=64 ¦ÌM), Bacillus subtilis 63501 (MIC=2 ¦ÌM, MBC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=8 ¦ÌM, MBC=16 ¦ÌM), Escherichia coli EC183 (MIC=2 ¦ÌM, MBC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM, MBC=8 ¦ÌM), Salmonella typhimurium C77-31 (MIC=8 ¦ÌM, MBC=32 ¦ÌM);##Fungi: Candida albicans 2.2086 (MIC=64 ¦ÌM, MFC=64 ¦ÌM), Candida albicans CA276 (MIC=128 ¦ÌM, MFC=128 ¦ÌM), Candida tropicalis 2.1975 (MIC=2 ¦ÌM, MFC=4 ¦ÌM), Candida krusei 2.1857 (MIC=8 ¦ÌM, MFC=16 ¦ÌM)."	"[Ref.27251456] Non-hemolysis upto 128 ¦ÌM, MHC>128 ¦ÌM against human red blood cells."	Linear	Free	Amidation	None	L	[Ref.27251456] No cytotoxicity information found	Not found	27251456	Sci Rep. 2016 Jun 2;6:27258. 	"Lyu Y, Yang Y, Lyu X, Dong N, Shan A."	"Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida."
DRAMP20811	RLKKIGKVLKWI	12	RI12 (PMAP-36 peptide derivative)	No entry found	Derived from PMAP-36	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	"Function: Antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and Fungi.."	"[Ref.27251456] Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=64 ¦ÌM, MBC=128 ¦ÌM), Staphylococcus aureus 25923 (MIC=128 ¦ÌM, MBC=128 ¦ÌM), Staphylococcus epidermidis 12228 (MIC=64 ¦ÌM, MBC=64 ¦ÌM), Bacillus subtilis 63501 (MIC=2 ¦ÌM, MBC=8 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=8 ¦ÌM, MBC=32 ¦ÌM), Escherichia coli EC183 (MIC=2 ¦ÌM, MBC=4 ¦ÌM), Escherichia coli 1005 (MIC=16 ¦ÌM, MBC=32 ¦ÌM), Salmonella typhimurium C77-31 (MIC=8 ¦ÌM, MBC=32 ¦ÌM);##Fungi: Candida albicans 2.2086 (MIC=128 ¦ÌM, MFC=128 ¦ÌM), Candida albicans CA276 (MIC=128 ¦ÌM, MFC=128 ¦ÌM), Candida tropicalis 2.1975 (MIC=8 ¦ÌM, MFC=8 ¦ÌM), Candida krusei 2.1857 (MIC=16 ¦ÌM, MFC=16 ¦ÌM)."	"[Ref.27251456] Non-hemolysis upto 128 ¦ÌM, MHC>128 ¦ÌM against human red blood cells."	Linear	Free	Amidation	None	L	[Ref.27251456] No cytotoxicity information found	Not found	27251456	Sci Rep. 2016 Jun 2;6:27258. 	"Lyu Y, Yang Y, Lyu X, Dong N, Shan A."	"Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida."
DRAMP20812	GILGKLWKGVKSIF	14	K8	No entry found	Belongs to the Hp1404 family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.26952110] Gram-positive bacteria:Staphylococcus aureus AB94004 (MIC=6.25¦Ìg/mL), Staphylococcus aureus ATCC6538 (MIC=6.25¦Ìg/mL), Staphylococcus aureus ATCC25923 (MIC=12.5¦Ìg/mL), Staphylococcus aureus MRSA P1381 (MIC=6.25¦Ìg/mL), Staphylococcus aureus MRSA P1374 (MIC=6.25¦Ìg/mL);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=25¦Ìg/mL), Escherichia coli ATCC25922 (MIC=100¦Ìg/mL), Pseudomonas aeruginosa AB93066 (MIC=50¦Ìg/mL), Pseudomonas aeruginosa ATCC9027 (MIC=25¦Ìg/mL)"	"[Ref.26952110] 2% hemolysis at 50¦Ìg/mL, 20% hemolysis at 100¦Ìg/mL, 45% hemolysis at 200¦Ìg/mL, 65% hemolysis at 400¦Ìg/mL against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.26952110] No cytotoxicity information found	Not found	26952110	Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77. 	"Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y, Cao Z."	K1K8: an Hp1404-derived antibacterial peptide
DRAMP20813	LILGKLWKGVKSIF	14	L1K8	No entry found	Belongs to the Hp1404 family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.26952110] Gram-positive bacteria:Staphylococcus aureus AB94004 (MIC=12.5¦Ìg/mL), Staphylococcus aureus ATCC6538 (MIC=12.5¦Ìg/mL), Staphylococcus aureus ATCC25923 (MIC=12.5¦Ìg/mL), Staphylococcus aureus MRSA P1381 (MIC=25¦Ìg/mL), Staphylococcus aureus MRSA P1374 (MIC=6.25¦Ìg/mL);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=50¦Ìg/mL), Escherichia coli ATCC25922 (MIC=100¦Ìg/mL), Pseudomonas aeruginosa AB93066 (MIC=100¦Ìg/mL), Pseudomonas aeruginosa ATCC9027 (MIC=25¦Ìg/mL)"	"[Ref.26952110] 2% hemolysis at 200¦Ìg/mL, 10% hemolysis at 400¦Ìg/mL against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.26952110] No cytotoxicity information found	Not found	26952110	Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77. 	"Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y, Cao Z."	K1K8: an Hp1404-derived antibacterial peptide
DRAMP20814	SILGKLWKGVKSIF	14	S1K8	No entry found	Belongs to the Hp1404 family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.26952110] Gram-positive bacteria:Staphylococcus aureus AB94004 (MIC=6.25¦Ìg/mL), Staphylococcus aureus ATCC6538 (MIC=6.25¦Ìg/mL), Staphylococcus aureus ATCC25923 (MIC=6.25¦Ìg/mL), Staphylococcus aureus MRSA P1381 (MIC=12.5¦Ìg/mL), Staphylococcus aureus MRSA P1374 (MIC=6.25¦Ìg/mL);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=25¦Ìg/mL), Escherichia coli ATCC25922 (MIC=50¦Ìg/mL), Pseudomonas aeruginosa AB93066 (MIC=50¦Ìg/mL), Pseudomonas aeruginosa ATCC9027 (MIC=25¦Ìg/mL)"	"[Ref.26952110] 15% hemolysis at 200¦Ìg/mL, 45% hemolysis at 400¦Ìg/mL against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.26952110] No cytotoxicity information found	Not found	26952110	Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77. 	"Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y, Cao Z."	K1K8: an Hp1404-derived antibacterial peptide
DRAMP20815	FILGKLWKGVKSIF	14	F1K8	No entry found	Belongs to the Hp1404 family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.26952110] Gram-positive bacteria:Staphylococcus aureus AB94004 (MIC=6.25¦Ìg/mL), Staphylococcus aureus ATCC6538 (MIC=6.25¦Ìg/mL), Staphylococcus aureus ATCC25923 (MIC=6.25¦Ìg/mL), Staphylococcus aureus MRSA P1381 (MIC=12.5¦Ìg/mL), Staphylococcus aureus MRSA P1374 (MIC=12.5¦Ìg/mL);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=25¦Ìg/mL), Escherichia coli ATCC25922 (MIC=50¦Ìg/mL), Pseudomonas aeruginosa AB93066 (MIC=50¦Ìg/mL), Pseudomonas aeruginosa ATCC9027 (MIC=50¦Ìg/mL)"	"[Ref.26952110] 2% hemolysis at 100¦Ìg/mL, 35% hemolysis at 200¦Ìg/mL, 70% hemolysis at 400¦Ìg/mL against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.26952110] No cytotoxicity information found	Not found	26952110	Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77. 	"Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y, Cao Z."	K1K8: an Hp1404-derived antibacterial peptide
DRAMP20816	KILGKLWKGVKSIF	14	K1K8	No entry found	Belongs to the Hp1404 family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.26952110] Gram-positive bacteria:Staphylococcus aureus AB94004 (MIC=6.25¦Ìg/mL), Staphylococcus aureus ATCC6538 (MIC=12.5¦Ìg/mL), Staphylococcus aureus ATCC25923 (MIC=12.5¦Ìg/mL), Staphylococcus aureus MRSA P1381 (MIC=6.25¦Ìg/mL), Staphylococcus aureus MRSA P1374 (MIC=6.25¦Ìg/mL);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=25¦Ìg/mL), Escherichia coli ATCC25922 (MIC=50¦Ìg/mL), Pseudomonas aeruginosa AB93066 (MIC=50¦Ìg/mL), Pseudomonas aeruginosa ATCC9027 (MIC=50¦Ìg/mL)"	[Ref.26952110] 10% hemolysis at 400¦Ìg/mL against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26952110] The cell vaibility of HFF cell lines is 100%, 108%, 105%  and 38% at peptide concentrations of 0 ¦Ìg/ml, 50 ¦Ìg/ml, 100 ¦Ìg/ml and 200 ¦Ìg/ml. ##The cell viability of HEK293T cell lines is 105%, 125%, 101% and 21% at peptide concentrations of"	Not found	26952110	Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77. 	"Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y, Cao Z."	K1K8: an Hp1404-derived antibacterial peptide
DRAMP20817	RRLIRLILRLLR	12	RR12	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.26795535] Gram-positive bacteria:Bacillus subtilis lab strain (MIC=8¦ÌM), Staphylococcus aureus ATCC25923 (MIC=8¦ÌM), Streptococcus pyogenes ATCC19615 (MIC=12.5¦ÌM), Enterococcus feacalis ATCC29212 (MIC=10¦ÌM);##Gram-negative bacteria:Escherichia coli lab strain (MIC=8¦ÌM), Pseudomonas aeruginosa ATCC27853 (MIC=12.5¦ÌM), Klebsiella pneumoniae ATCC13883 (MIC=8¦ÌM), Salmonella enterica ATCC14028 (MIC=10¦ÌM)"	"[Ref.26795535] 4% hemolysis at 25¦ÌM, 10% hemolysis at 50¦ÌM, 32% hemolysis at 100¦ÌM against mice red cells"	Linear	Free	Amidation	None	L	[Ref.26849911] No cytotoxicity information found	Not found	26849911	Biopolymers. 2016 May;106(3):345-56. 	"Mohanram H, Bhattacharjya S."	Salt-resistant short antimicrobial peptides
DRAMP20818	RRLIWLILRLLR	12	RR12Wpolar	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.26795535] Gram-positive bacteria:Bacillus subtilis lab strain (MIC=4¦ÌM), Staphylococcus aureus ATCC25923 (MIC=4¦ÌM), Streptococcus pyogenes ATCC19615 (MIC=4¦ÌM), Enterococcus feacalis ATCC29212 (MIC=8¦ÌM);##Gram-negative bacteria:Escherichia coli lab strain (MIC=8¦ÌM), Pseudomonas aeruginosa ATCC27853 (MIC=10¦ÌM), Klebsiella pneumoniae ATCC13883 (MIC=4¦ÌM), Salmonella enterica ATCC14028 (MIC=10¦ÌM)"	"[Ref.26795535] 5% hemolysis at 5 ¦ÌM, 12% hemolysis at 10 ¦ÌM, 32% hemolysis at 25 ¦ÌM, 60% hemolysis at 50 ¦ÌM, 78% hemolysis at 100 ¦ÌM against mice red cells"	Linear	Free	Amidation	None	L	[Ref.26849911] No cytotoxicity information found	Not found	26849911	Biopolymers. 2016 May;106(3):345-56. 	"Mohanram H, Bhattacharjya S."	Salt-resistant short antimicrobial peptides
DRAMP20819	RRLIRLWLRLLR	12	RR12Whydro	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.26795535] Gram-positive bacteria:Bacillus subtilis lab strain (MIC=4¦ÌM), Staphylococcus aureus ATCC25923 (MIC=8¦ÌM), Streptococcus pyogenes ATCC19615 (MIC=8¦ÌM), Enterococcus feacalis ATCC29212 (MIC=8¦ÌM);##Gram-negative bacteria:Escherichia coli lab strain (MIC=4¦ÌM), Pseudomonas aeruginosa ATCC27853 (MIC=10¦ÌM), Klebsiella pneumoniae ATCC13883 (MIC=4¦ÌM), Salmonella enterica ATCC14028 (MIC=8¦ÌM)"	"[Ref.26795535] 2% hemolysis at 25 ¦ÌM, 5% hemolysis at 50¦ÌM, 18% hemolysis at 100¦ÌM against mice red cells"	Linear	Free	Amidation	None	L	[Ref.26849911] No cytotoxicity information found	Not found	26849911	Biopolymers. 2016 May;106(3):345-56. 	"Mohanram H, Bhattacharjya S."	Salt-resistant short antimicrobial peptides
DRAMP20820	FRIRVRV	7	FV7	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.28178190] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=64 ¦ÌM), Streptococcus Faecalis ATCC 29212 (MIC=32 ¦ÌM), Bacillus subtilis CMCC 63501 (MIC=16 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=32 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 ¦ÌM), Escherichia coli UB 1005 (MIC=32 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=32 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC=16 ¦ÌM), Salmonella typhimurium ATCC 7731 (MIC=32 ¦ÌM)."	[Ref.28178190] 3% hemolysis at 128 ¦ÌM against human red cells	Linear	Free	Amidation	None	L	[Ref.28178190] No cytotoxicity information found	Not found	28178190	Int J Mol Sci. 2017 Feb 6;18(2). 	"Tan T, Wu D, Li W, Zheng X, Li W, Shan A."	High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
DRAMP20821	FRIRVRVFKRIVQRIKDFLR	20	"FV-LL (FV7 and LL(LL-37,(17-29)) hybrid peptide)"	No entry found	"FV7 and LL(LL-37,(17-29)) hybrid peptide"	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, random coil"	The hybrid peptide displayed an unordered conformation in phosphate buffer.	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.28178190] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=2 ¦ÌM), Streptococcus Faecalis ATCC 29212 (MIC=4 ¦ÌM), Bacillus subtilis CMCC 63501 (MIC=4 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=1 ¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=1 ¦ÌM), Escherichia coli UB 1005 (MIC=4 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=2 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC=2 ¦ÌM), Salmonella typhimurium ATCC 7731 (MIC=2 ¦ÌM)."	[Ref.28178190] 2% hemolysis at 128 ¦ÌM against human red cells	Linear	Free	Amidation	None	L	[Ref.28178190] No cytotoxicity information found	Not found	28178190	Int J Mol Sci. 2017 Feb 6;18(2). 	"Tan T, Wu D, Li W, Zheng X, Li W, Shan A."	High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
DRAMP20822	FRIRVRVAKKFGKAFVGEIM	20	FV-MA (FV7 and MA(Magainin 2 (9-21))  hybrid peptide)	No entry found	FV7 and MA(Magainin 2 (9-21))  hybrid peptide	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, random coil"	The hybrid peptide displayed an unordered conformation in phosphate buffer.	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.28178190] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=8 ¦ÌM), Streptococcus Faecalis ATCC 29212 (MIC=16 ¦ÌM), Bacillus subtilis CMCC 63501 (MIC=4 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=8 ¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=8 ¦ÌM), Escherichia coli UB 1005 (MIC=8 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=2 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC=4 ¦ÌM), Salmonella typhimurium ATCC 7731 (MIC=4 ¦ÌM)."	"[Ref.28178190] 1% hemolysis at 2 ¦ÌM, 8% hemolysis at 4 ¦ÌM, 10% hemolysis at 8 ¦ÌM, 15% hemolysis at 16 ¦ÌM, 20% hemolysis at 32 ¦ÌM, 37% hemolysis at 64 ¦ÌM, 55% hemolysis at 128 ¦ÌM against human red cells"	Linear	Free	Amidation	None	L	[Ref.28178190] No cytotoxicity information found	Not found	28178190	Int J Mol Sci. 2017 Feb 6;18(2). 	"Tan T, Wu D, Li W, Zheng X, Li W, Shan A."	High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
DRAMP20823	FRIRVRVKWKLFKKI	15	FV-CE (FV7 and CE(Cecropin A (1	No entry found	FV7 and CE(Cecropin A (1	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil	The hybrid peptide displayed an unordered conformation in phosphate buffer.	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.28178190] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=8 ¦ÌM), Streptococcus Faecalis ATCC 29212 (MIC=1 ¦ÌM), Bacillus subtilis CMCC 63501 (MIC=1 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=0.5 ¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=2 ¦ÌM), Escherichia coli UB 1005 (MIC=2 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=2 ¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=2 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC=4 ¦ÌM), Salmonella typhimurium ATCC 7731 (MIC=4 ¦ÌM)."	"[Ref.28178190] 1% hemolysis at 2 ¦ÌM, 5% hemolysis at 128 ¦ÌM against human red cells"	Linear	Free	Amidation	None	L	[Ref.28178190] No cytotoxicity information found	Not found	28178190	Int J Mol Sci. 2017 Feb 6;18(2). 	"Tan T, Wu D, Li W, Zheng X, Li W, Shan A."	High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
DRAMP20824	GLFKKLRRKIKKGFKKIFKRLPPIGVGVSIPLAGKR	36	AM-CATH36	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, random coil"	NA-CATH has previously been shown to be random coil in water or buffer and 	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.28089718] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21¦Ìg/ml), Staphylococcus aureus ATCC 33592 (MIC=21¦Ìg/ml);##Gram-negative bacteria:Acinetobacter baumannii ATCC 9955 (MIC=5.2¦Ìg/ml), Acinetobacter baumannii ATCC BAA-1794 (MIC=5.2¦Ìg/ml), Escherichia coli ATCC 4157 (MIC=140¦Ìg/ml), K. pneumoniae ATCC 33495 (MIC=5.2¦Ìg/ml), K. pneumoniae ATCC BAA-1705 (MIC=5.6¦Ìg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=5.2¦Ìg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (MIC=5.2¦Ìg/ml)"	[Ref.28089718] 0% hemolysis at 300¦Ìg/ml against sheep red cells	Linear	Free	Free	None	L	[Ref.28089718] The survival rate of A549 human lung epithelial cells is 124% at a peptide concentration of 300 ¦Ìg/ml	Not found	28089718	Dev Comp Immunol. 2017 May;70:135-144. 	"Barksdale SM, Hrifko EJ, van Hoek ML."	Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae
DRAMP20825	KIKKGFKKIFKRLPPIGVGVSIPLAGKR	28	AM-CATH28	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	"Alpha helix, random coil"	NA-CATH has previously been shown to be random coil in water or buffer and 	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.28089718] Gram-negative bacteria:Acinetobacter baumannii ATCC 9955 (MIC=28¦Ìg/ml), Acinetobacter baumannii ATCC BAA-1794 (MIC=10¦Ìg/ml), K. pneumoniae ATCC 33495 (MIC=5.6¦Ìg/ml), K. pneumoniae ATCC BAA-1705 (MIC=28¦Ìg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=21¦Ìg/ml)"	[Ref.28089718] 1% hemolysis at 300¦Ìg/ml against sheep red cells	Linear	Free	Free	None	L	[Ref.28089718] The survival rate of A549 human lung epithelial cells is 122% at a peptide concentration of 300 ¦Ìg/ml	Not found	28089718	Dev Comp Immunol. 2017 May;70:135-144. 	"Barksdale SM, Hrifko EJ, van Hoek ML."	Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae
DRAMP20826	GLFKKLRRKIKKGFKKIFKRL	21	AM-CATH21	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, random coil"	NA-CATH has previously been shown to be random coil in water or buffer and 	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.28089718] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=28¦Ìg/ml), Staphylococcus aureus ATCC 33592 (MIC=28¦Ìg/ml);##Gram-negative bacteria:Acinetobacter baumannii ATCC 9955 (MIC=42¦Ìg/ml), Acinetobacter baumannii ATCC BAA-1794 (MIC=10¦Ìg/ml), Escherichia coli ATCC 4157 (MIC=21¦Ìg/ml), Escherichia coli ATCC 51659 (MIC=140¦Ìg/ml), K. pneumoniae ATCC 33495 (MIC=5.2¦Ìg/ml), K. pneumoniae ATCC BAA-1705 (MIC=28¦Ìg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=10¦Ìg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (MIC=42¦Ìg/ml)"	[Ref.28089718] 0.5% hemolysis at 300¦Ìg/ml against sheep red cells	Linear	Free	Free	None	L	[Ref.28089718] The survival rate of A549 human lung epithelial cells is 113% at a peptide concentration of 300 ¦Ìg/ml	Not found	28089718	Dev Comp Immunol. 2017 May;70:135-144. 	"Barksdale SM, Hrifko EJ, van Hoek ML."	Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae
DRAMP20827	FLPIVGLLKSLLK	13	TB_L1FK	No entry found	Derived from TB	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria,antifungal activity."	"[Ref.28443279] Gram-positive bacteria: S.aureus ATCC 33591 (MIC=6¦ÌM), Staphylococcus epidermidis (MIC=1.5¦ÌM);##Gram-negative bacteria: Klebsiella pneumoniae ATCC BAA-1706 (MIC=6¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=6¦ÌM)"	"[Ref.28443279] 8% hemolysis at 48¦ÌM, 38% hemolysis at 96¦ÌM against human red cells"	Linear	Free	Amidation	None	L	[Ref.28443279] IC50 = 52 ¦ÌM against PBMCs. ##IC50 = 59 ¦ÌM against A549 cells	Not found	28443279	Front Chem. 2017 Apr 11;5:24	"Grassi L, Maisetta G, Maccari G, Esin S, Batoni G."	Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide
DRAMP20828	KKLLPIVANLLKSLL	15	TB_KKG6A	No entry found	Derived from TB	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	"Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria,antifungal activity."	"[Ref.28443279] Gram-positive bacteria: S.aureus ATCC 33591 (MIC=1.5¦ÌM), Staphylococcus epidermidis (MIC=1.5¦ÌM);##Gram-negative bacteria: Klebsiella pneumoniae ATCC BAA-1706 (MIC=3¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=3¦ÌM)"	"[Ref.28443279] 11% hemolysis at 48¦ÌM, 55% hemolysis at 96¦ÌM against human red cells"	Linear	Free	Amidation	None	L	[Ref.28443279] IC50 = 49 ¦ÌM against PBMCs. ##IC50 = 16 ¦ÌM against A549 cells	Not found	28443279	Front Chem. 2017 Apr 11;5:24	"Grassi L, Maisetta G, Maccari G, Esin S, Batoni G."	Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide
DRAMP20831	ILGKLWEGLKSLF	13	IsCT1L1	No entry found	Belongs to the scorpion NDBP 5 family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.28657596] Gram-positive bacteria:Staphylococcus aureus (MIC=50¦Ìg/mL);##Gram-negative bacteria: S. typhimurium (MIC=100¦Ìg/mL), Escherichia coli (MIC=50¦Ìg/mL)"	"[Ref.28657596] 1% hemolysis at 10 ¦Ìg/ml, 78% hemolysis at 50 ¦Ìg/ml, 90% hemolysis at 100 ¦Ìg/ml against human red cells"	Linear	Free	Amidation	None	L	[Ref.28657596] No cytotoxicity information found	Not found	28657596	Antibiotics (Basel). 2017 Jun 28;6(3). 	"de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM."	Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides
DRAMP20832	IDWKKLLNAAKQIL	14	Polybia-MP1S-D8N	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	"Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria, position 6 and 10 are cross-linked residues connected by the oct-4-enyl hydrocarbon staple"	"[Ref.29075946] Gram-positive bacteria: Bacillus subtilis (MIC=0.8¦ÌM), Staphylococcus aureus (MIC=0.8¦ÌM), Staphylococcus epidermidis (MIC=37.5¦ÌM);##Gram-negative bacteria:Escherichia coli (MIC=50¦ÌM), Shigella dysenteriae (MIC=100¦ÌM), Klebsiella pneumoniae (MIC=37.5¦ÌM)"	"[Ref.29075946] 16.3% hemolysis at 12.5¦ÌM, 37.8% hemolysis at 25¦ÌM against human red cells"	Cyclic	Free	Amidation	The oct-4-enyl hydrocarbon staple between Leu6 and Ala10	L	[Ref.29075946] No cytotoxicity information found	Not found	29075946	Arch Pharm Res. 2017 Dec;40(12):1414-1421.	"Luong HX, Kim DH, Lee BJ, Kim YW"	Antimicrobial activity and stability of stapled helices of polybia-MP1
DRAMP20833	FVPWFSKFLGRIL	13	"[Pro3,DLeu9]TL(1) (Temporin L peptide derivative)"	No entry found	Derived from Temporin L	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	The analogues bearing a D residue shows a reduction in the percentage of helicity compared to the corresponding L analogues in the MMs 	None	"Function: Antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteria and Fungi. The position 9 of [Pro3,DLeu9]TL(1) is D-Leucine."	"[Ref.28863356] Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3.125¦ÌM), Staphylococcus aureus Cowan I (MIC=12.5¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=6.25¦ÌM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=12.5¦ÌM), Escherichia coli D21 (MIC=12.5¦ÌM), Pseudomonas syringae pv tabaci 1918 (MIC=12.5¦ÌM), Pseudomonas aeruginosa ATCC 2785 (MIC=50¦ÌM);##Yeasts: Candida albicans ATCC 10231 (MIC=3.125¦ÌM), Candida crusei ATCC 6258 (3.125¦ÌM)."	"[Ref.28863356] 21¡À4% hemolysis at 50¦ÌM, 7¡À3% hemolysis at 25¦ÌM, 6¡À3% hemolysis at 12.5¦ÌM, 3¡À2% hemolysis at 6.25¦ÌM, 1¡À1%  hemolysis at 3.125¦ÌM against human red blood cells.##20.63 ¡À 2.66% cytotoxic effect at 12.5¦ÌM, 57.52 ¡À 3.99%  cytotoxic effect at 25¦ÌM, 91.58 ¡À 3.85% cytotoxic effect at 50 ¦ÌM on HaCaT cells."	Linear	Free	Amidation	None	Mixed (D-Leu9)	"[Ref.28863356] The cytotoxic effects of the peptide are 20.63¡À2.66%, 57.52¡À3.99% and 91.58¡À3.85% at 12.5, 25 and 50 ¦ÌM "	Not found	28863356	Eur J Med Chem. 2017 Oct 20;139:750-761.	"Merlino F, Carotenuto A, Casciaro B, Martora F, Loffredo MR, Di Grazia A, Yousif AM, Brancaccio D, Palomba L, Novellino E, Galdiero M, Iovene MR, Mangoni ML, Grieco P."	"Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities"
DRAMP20834	RWQWRWQWR	9	PLS	No entry found	Not found	Not found	Not found	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria	"[Ref.29551999] Gram-negative bacteria:E. faecalis-sensitive strain (MIC=25.6 ¦ÌM),Staphylococcus aureus-sensitive strain (MIC=34.9 ¦ÌM),,Staphylococcus aureus-resistant strain (MIC=25.0 ¦ÌM);##Gram-positive bacteria:Klebsiella pneumoniaae-sensitive strain (MIC=30.7 ¦ÌM),Klebsiella pneumoniaae-resistant strain (MIC=26.2 ¦ÌM),Pseudomonas aeruginosa-sensitive strain (MIC=99.7 ¦ÌM),Pseudomonas aeruginosa-resistant strain (MIC=107.2 ¦ÌM)"	"[Ref.29551999] 24.8% hemolysis at 100¦ÌM,50% hemolysis at >100¦ÌM against human red cells"	Linear	Free	Free	None	L	[Ref.29551999] No cytotoxicity information found	Not found	29551999	Front Microbiol. 2018 Mar 2;9:329.	"Vega SC, Mart"	"Design, Synthesis and Evaluation of Branched RRWQWR-Based Peptides as Antibacterial Agents against Clinically Relevant Gram-Positive and Gram-Negative Pathogens"
DRAMP20837	KRVKRFKKFFRKIKKGFRKIFKKTKIFIGGT	31	Pb-CATH1 Python bivittatus  antimicrobial peptides peptide derivative	No entry found	Derived from cathelicidin family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive 	[Ref.28630199]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=2¦Ìg/ml);Pseudomonas aeruginosa (ATCC 27853)(MIC=3¦Ìg/ml);S. typhimurium (ATCC 14028)(MIC=1.5¦Ìg/ml);##Gram-positive bacteria:Staphylococcus aureus (ATCC 29213)(MIC>128¦Ìg/ml);B. cereus (ATCC 10876)(MIC=46¦Ìg/ml)	[Ref.28630199] 0% hemolysis at 4¦Ìg/ml against human red blood cell; 1.4 ¡À 0.4% hemolysis at 8¦Ìg/ml against human red blood cell; 5.1 ¡À 0.5% hemolysis at 16¦Ìg/ml against human red blood cell;7.3 ¡À 0.6% hemolysis at 32¦Ìg/ml against human red blood cell; 12.2 ¡À 0.7% hemolysis at 64¦Ìg/ml against human red blood cell	Linear	Free	Free	None	L	[Ref.28630199] No cytotoxicity information found	Not found	28630199	Antimicrob Agents Chemother. 2017 Aug 24;61(9). 	"Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C."	Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity.
DRAMP20838	TRSRWRRFIRGAGRFARRYGWRIAL	25	Pb-CATH4 bivittatus  antimicrobial peptides peptide derivative 	No entry found	Derived from cathelicidin family	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	"The peptide adopts arginine content of this peptide is 37.5%, and it contains two tryptophan residues (8.3%)"	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria	[Ref.28630199]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=1¦Ìg/ml);Pseudomonas aeruginosa (ATCC 27853)(MIC=3¦Ìg/ml);S. typhimurium (ATCC 14028)(MIC=0.5¦Ìg/ml);##Gram-positive bacteria:Staphylococcus aureus (ATCC 29213)(MIC>128¦Ìg/ml);B. cereus (ATCC 10876)(MIC=10¦Ìg/ml);##Clinical isolates:Escherichia coli(MIC=4.7¦Ìg/ml);K. pneumoniae(MIC=1.18¦Ìg/ml)	[Ref.28630199] 0% hemolysis at 4¦Ìg/ml against human red blood cell; 1.4 ¡À 0.4% hemolysis at 8¦Ìg/ml against human red blood cell; 5.1 ¡À 0.5% hemolysis at 16¦Ìg/ml against human red blood cell;7.3 ¡À 0.6% hemolysis at 32¦Ìg/ml against human red blood cell; 12.2 ¡À 0.7% hemolysis at 64¦Ìg/ml against human red blood cell	Linear	Free	Free	None	L	"[Ref.28630199] The cell viability of Pk15(pig kidney fibroblasts) is 103.8%, 124.6%, 94.7%,55.2% and 53.9% at peptide concentrations of 5, 10, 20, 30 and 64 ¦Ìg/ml. ##The cell viability of HaCaT(human keratinocytes) is 106.9%, 94.6%, 66.2%, 58.1% and 51."	Not found	28630199	Antimicrob Agents Chemother. 2017 Aug 24;61(9). 	"Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C."	Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity.
DRAMP20839	GFVALLKKLPLILKHLH	17	Xylopin 	C0HKQ5	Not found	Not found	Xylocopa appendiculata circumvolans	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Linear cationic alpha-helical	Not found	None	"Function: Antimicrobial and mast cell degranulating peptide which probably acts by forming pores in membranes (PubMed:28546807, PubMed:28855917). Active against both Gram-negative and Gram-positive bacterial strains as well as against yeasts (PubMed:28546807, PubMed:28855917). Has leishmanicidal activity (IC50=25uM)(PubMed:28855917). Has little hemolytic activity (PubMed:28546807, PubMed:28855917)"	[Ref.28855917]Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=15.0¦ÌM);Micrococcus luteus (ATCC 10240)(MIC=1.9¦ÌM);Bacillus subtilis (ATCC 6633)(MIC=3.75¦ÌM);Streptococcus pyogenes (CS)(MIC=3.75¦ÌM);Streptococcus agalactiae (CS)(MIC=3.75¦ÌM);Enterococcus. faecalis (CS)(MIC=15.0¦ÌM);##Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=3.75¦ÌM);Pseudomonas aeruginosa (ATCC 27853)(MIC=7.5¦ÌM);Stenotrophomonas maltophilia (ATCC 13637)(MIC=3.75¦ÌM);Shigella boydii (CS)(MIC=3.75¦ÌM);Klebsiella pneumoniae (CS)(MIC=7.5¦ÌM);Serratia marcescens (CS)(MIC=7.5¦ÌM);Enterobacter cloacae (CS)(MIC=7.5¦ÌM);Proteus mirabilis (CS)(MIC>30¦ÌM);Morganella morgannii (CS)(MIC=30¦ÌM);Acinetobacter baumanii/calcoaceticus (CS)(MIC=3.75¦ÌM) ;##Yeasts:Candida albicans (ATCC 90112)(MIC=7.5¦ÌM);Sacharomyces cerevisae(MIC=3.75¦ÌM)	[Ref.28855917]IC50=25uM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.28855917] No cytotoxicity information found	Not found	28855917	J Venom Anim Toxins Incl Trop Dis. 2017 Aug 29;23:40.	"Kazuma K, Ando K, Nihei KI, Wang X, Rangel M, Franzolin MR, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K."	Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans.
DRAMP20841	SKVWRHWRRFWHRAHRLH	18	C1b	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	"The peptide adopts an low alpha-helical content when dissolved in water.  However, the peptides displayed 3.23"	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=6.25¦ÌM);Pseudomonas aeruginosa(MIC=1.56¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC=3.13¦ÌM);B. cereus(MIC=3.13¦ÌM);S. lactis(MIC=3.13¦ÌM);E. faecalis (MIC=1.56¦ÌM);E. faecium(MIC=3.13¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-1b analogues.
DRAMP20842	SKVWRHWRRFW	11	C1b(1-11)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=12.5¦ÌM);Pseudomonas aeruginosa(MIC=3.13¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 6.25¦ÌM);B. cereus(MIC=6.25¦ÌM);S. lactis(MIC=6.25¦ÌM);E. faecalis (MIC=6.25¦ÌM);E. faecium(MIC=6.25¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-2b analogues.
DRAMP20843	SKVWRHWRRFWHR	13	C1b(1-13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	The peptide adopts 41.93% alpha-helical	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=6.25¦ÌM);Pseudomonas aeruginosa(MIC=3.13¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 3.13¦ÌM);B. cereus(MIC=1.56¦ÌM);S. lactis(MIC=3.13¦ÌM);E. faecalis (MIC=3.13¦ÌM);E. faecium(MIC=6.25¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-3b analogues.
DRAMP20844	VWRHWRRFWHR	11	C1b(3-13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	The peptide adopts 53.49% alpha-helical	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=6.25¦ÌM);Pseudomonas aeruginosa(MIC=3.13¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 3.13¦ÌM);B. cereus(MIC=3.13¦ÌM);S. lactis(MIC=6.25¦ÌM);E. faecalis (MIC=3.13¦ÌM);E. faecium(MIC=3.13¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-4b analogues.
DRAMP20845	VWRHWRRFW	9	C1b(3-11)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=25¦ÌM);Pseudomonas aeruginosa(MIC=50¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC=25¦ÌM);B. cereus(MIC=50¦ÌM);S. lactis(MIC=100¦ÌM);E. faecalis (MIC=100¦ÌM);E. faecium(MIC=50¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-6b analogues.
DRAMP20846	VWRHWRRFWH	10	C1b(3-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=50¦ÌM);Pseudomonas aeruginosa(MIC=12.5¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 12.25¦ÌM);B. cereus(MIC=6.25¦ÌM);S. lactis(MIC=12.25¦ÌM);E. faecalis (MIC=12.25¦ÌM);E. faecium(MIC=6.25¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-7b analogues.
DRAMP20847	WRHWRRFWHR	10	C1b(4-13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	The peptide adopts 65.69% alpha-helical	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=25¦ÌM);Pseudomonas aeruginosa(MIC=3.13¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 50¦ÌM);B. cereus(MIC=6.25¦ÌM);S. lactis(MIC=6.25¦ÌM);E. faecalis (MIC=3.13¦ÌM);E. faecium(MIC=6.25¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-8b analogues.
DRAMP20848	VWRKWRRFW	9	[K4]C1b(3-11)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=6.25¦ÌM);Pseudomonas aeruginosa(MIC=6.25¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 6.25¦ÌM);B. cereus(MIC=6.25¦ÌM);S. lactis(MIC=3.13¦ÌM);E. faecalis (MIC=3.13¦ÌM);E. faecium(MIC=3.13¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-9b analogues.
DRAMP20849	VWRRWRRFW	9	[R4]C1b(3-11)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	The peptide adopts 3.23% alpha-helical	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=12.5¦ÌM);Pseudomonas aeruginosa(MIC=6.25¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 12.25¦ÌM);B. cereus(MIC=6.25¦ÌM);S. lactis(MIC=12.25¦ÌM);E. faecalis (MIC=12.25¦ÌM);E. faecium(MIC=12.5¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-10b analogues.
DRAMP20850	VWRKWRRFWKR	11	"[K4,K10]C1b(3-13)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=3.13¦ÌM);Pseudomonas aeruginosa(MIC=1.56¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 6.25¦ÌM);B. cereus(MIC=3.13¦ÌM);S. lactis(MIC=6.25¦ÌM);E. faecalis (MIC=6.25¦ÌM);E. faecium(MIC=6.25¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-11b analogues.
DRAMP20851	VWRRWRRFWRR	11	"[R4,R10]C1b(3-13)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Random coil conformation	The peptide adopts 70.2% alpha-helical	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27060618]Gram-negative bacteria:Escherichia coli(MIC=3.13¦ÌM);Pseudomonas aeruginosa(MIC=3.13¦ÌM);##Gram-positive bacteria:Staphylococcus aureus(MIC= 3.13¦ÌM);B. cereus(MIC=3.13¦ÌM);S. lactis(MIC=3.13¦ÌM);E. faecalis (MIC=1.56¦ÌM);E. faecium(MIC=1.56¦ÌM)	[Ref.27060618] HC50>500¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27060618] No cytotoxicity information found	Not found	27060618	Acta Biomater. 2016 Jun;37:59-68.	"Dong W, Dong Z, Mao X, Sun Y, Li F, Shang D."	Structure-activity analysis and biological studies of chensinin-12b analogues.
DRAMP20852	ONNRPVYIPRPRPPHPRL	18	Api137 apidaecin petide derivative	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=2¦Ìg/mL);K. pneumoniae (DSM 681)(MIC=16¦Ìg/mL);##Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=256¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>256¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>256¦Ìg/mL);##Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>256¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>256¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>256¦Ìg/mL);Rat cardiomyocytes(IC50>0.6g/L);HEK293 cells(IC50>0.6g/L);HeLa cells(IC50>0.6g/L)	[Ref.27243004] 0.4 ¡À 0.5% hemolysis at 0.1 g/L; 1.0 ¡À 0.2% hemolysis at 0.6 g/L against human red blood cells	Linear	"Guanidation (Orn1 conjugated with N,N,N¡ä,N¡ä-tetramethylguanidino)"	Free	The 'O' in sequence is Ornithine	L	[Ref.27243004] IC50 > 0.6 g/L against Rat cardiomyocytes. ##IC50 > 0.6g/L against HEK293. ##IC50 > 0.6g/L against HeLa.	Not found	27243004	Front Cell Dev Biol. 2016 May 10;4:39. 	"Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R."	N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
DRAMP20853	OIORPVYOPRPRPPHPRL	18	Api755 apidaecin petide derivative	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=8¦Ìg/mL);K. pneumoniae (DSM 681)(MIC=8¦Ìg/mL);##Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=16¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>64¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>16¦Ìg/mL);##Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>128¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>256¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>128¦Ìg/mL)	No hemolysis information or data found in the reference(s) presented in this entry	Linear	"Guanidation (Orn1 conjugated with N,N,N¡ä,N¡ä-tetramethylguanidino)"	Free	The 'O' in sequence is Ornithine	L	[Ref.27243004] No cytotoxicity information found.	Not found	27243004	Front Cell Dev Biol. 2016 May 10;4:39. 	"Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R."	N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
DRAMP20854	OWORPVYOPRPRPPHPRL	18	Api760 apidaecin petide derivative	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=8¦Ìg/mL);K. pneumoniae (DSM 681)(MIC=8¦Ìg/mL);##Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=16¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>32¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>8¦Ìg/mL);##Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>128¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>256¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>128¦Ìg/mL)	No hemolysis information or data found in the reference(s) presented in this entry	Linear	"Guanidation (Orn1 conjugated with N,N,N¡ä,N¡ä-tetramethylguanidino)"	Free	The 'O' in sequence is Ornithine	L	[Ref.27243004] No cytotoxicity information found.	Not found	27243004	Front Cell Dev Biol. 2016 May 10;4:39. 	"Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R."	N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
DRAMP20855	OWOWORPVYOPRPRPPHPRL	20	Api793 apidaecin petide derivative	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=8¦Ìg/mL);K. pneumoniae (DSM 681)(MIC=16¦Ìg/mL);##Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=16¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>16¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>8¦Ìg/mL);##Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>64¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>256¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>64¦Ìg/mL);Rat cardiomyocytes(IC50>0.6g/L);HEK293 cells(IC50=0.64 ¡À 0.05g/L);HeLa cells(IC50=0.64 ¡À 0.05g/L)	[Ref.27243004] 1.3 ¡À 0.4% hemolysis at 0.1 g/L; 1.6 ¡À 0.5% hemolysis at 0.6 g/L against human red blood cells	Linear	"Guanidation (Orn1 conjugated with N,N,N¡ä,N¡ä-tetramethylguanidino)"	Free	The 'O' in sequence is Ornithine	L	[Ref.27243004] IC50 > 0.6 g/L against Rat cardiomyocytes.## IC50 = 0.64 ¡À 0.05 g/L against HEK293. IC50 = 0.64 ¡À 0.15 g/L against HeLa.	Not found	27243004	Front Cell Dev Biol. 2016 May 10;4:39. 	"Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R."	N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
DRAMP20856	OWOWOWORPVYOPRPRPPHPRL	22	Api794 apidaecin petide derivative	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria; highly active against Pseudomonas aeruginosa in vitro	[Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=16¦Ìg/mL);K. pneumoniae (DSM 681)(MIC=32¦Ìg/mL);##Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=16¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>16¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>16¦Ìg/mL);##Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>32¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>128¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>16¦Ìg/mL);Rat cardiomyocytes(IC50>0.6g/L);HEK293 cells(IC50>0.6g/L);HeLa cells(IC50>0.6g/L)	[Ref.27243004] 1.7 ¡À 0.2% hemolysis at 0.1 g/L; 1.9 ¡À 0.3% hemolysis at 0.6 g/L against human red blood cells	Linear	"Guanidation (Orn1 conjugated with N,N,N¡ä,N¡ä-tetramethylguanidino)"	Free	The 'O' in sequence is Ornithine	L	[Ref.27243004] IC50 > 0.6 g/L against Rat cardiomyocytes.## IC50 = 0.28 ¡À 0.03 g/L against HEK293. IC50 = 0.23 ¡À 0.09 g/L against HeLa.	Not found	27243004	Front Cell Dev Biol. 2016 May 10;4:39. 	"Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R."	N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
DRAMP20857	OIOIORPVYOPRPRPPHPRL	20	Api795 apidaecin petide derivative	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria; highly active against Pseudomonas aeruginosa in vitro	[Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=8¦Ìg/mL);K. pneumoniae (DSM 681)(MIC=8¦Ìg/mL);##Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=8¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>16¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>8¦Ìg/mL);##Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>32¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>256¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>128¦Ìg/mL);Rat cardiomyocytes(IC50>0.6g/L);HEK293 cells(IC50>0.6g/L);HeLa cells(IC50>0.6g/L)	[Ref.27243004] 0.8 ¡À 0.4% hemolysis at 0.1 g/L; 0.0 ¡À 0.7% hemolysis at 0.6 g/L against human red blood cells	Linear	"Guanidation (Orn1 conjugated with N,N,N¡ä,N¡ä-tetramethylguanidino)"	Free	The 'O' in sequence is Ornithine	L	[Ref.27243004] IC50 > 0.6 g/L against Rat cardiomyocytes.## IC50 > 0.6g/L against HEK293. IC50 > 0.6g/L against HeLa.	Not found	27243004	Front Cell Dev Biol. 2016 May 10;4:39. 	"Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R."	N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
DRAMP20858	OIOIOIORPVYOPRPRPPHPRL	22	Api796 apidaecin petide derivative	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.27243004]Gram-negative bacteria: Escherichia coli (ATCC 25922 )(MIC=8¦Ìg/mL);K. pneumoniae (DSM 681)(MIC=16¦Ìg/mL);##Gram-positive bacteria:50% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC=8¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>16¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>16¦Ìg/mL);##Gram-positive bacteria:100% MHB:Pseudomonas aeruginosa(DSM 1117)(MIC>64¦Ìg/mL);Pseudomonas aeruginosa(DSM 3227)(MIC>128¦Ìg/mL);Pseudomonas aeruginosa(DSM 9644)(MIC>128¦Ìg/mL);Rat cardiomyocytes(IC50>0.6g/L);HEK293 cells(IC50>0.6g/L);HeLa cells(IC50>0.6g/L)	[Ref.27243004] 0.8 ¡À 0.2% hemolysis at 0.1 g/L;¦Ì0.1 ¡À 0.8 % hemolysis at 0.6 g/L against human red blood cells	Linear	"Guanidation (Orn1 conjugated with N,N,N¡ä,N¡ä-tetramethylguanidino)"	Free	The 'O' in sequence is Ornithine	L	[Ref.27243004] IC50 > 0.6 g/L against Rat cardiomyocytes.## IC50 > 0.6g/L against HEK293. IC50 > 0.6g/L against HeLa.	Not found	27243004	Front Cell Dev Biol. 2016 May 10;4:39. 	"Bluhm ME, Schneider VA, Sch?fer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R."	N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
DRAMP20859	KFRTRRSKSSSNGGRKGSKG	20	TT(1-24)	No entry found	Derived from Cathelicidins	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Unconventional feature	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. TT(1	[Ref.27818338]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=32¦ÌM);A. salmonicida (ATCC 33658)(MIC=32-16¦ÌM);Y. ruckeri (NCIMB 1315)(MIC=32¦ÌM);V. anguillarum (ATCC 43305 With addition of 2% NaCl)(MIC>32¦ÌM);A. hydrophila (ATCC 7966)(MIC>32¦ÌM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=64¦ÌM);L. garvieae (ATCC 49156)(MIC=16-8¦ÌM)	[Ref.27818338] No hemolytic activity to human	Linear	Free	Free	None	L	[Ref.27818338] No cytotoxicity information found	Not found	27818338	Fish Shellfish Immunol. 2016 Dec;59:456-468. 	"D'Este F, Benincasa M, Cannone G, Furlan M, Scarsini M, Volpatti D, Gennaro R, Tossi A, Skerlavaj B, Scocchi M."	Antimicrobial and host cell-directed activities of Gly/Ser-rich peptides from salmonid cathelicidins.
DRAMP20860	KFRTRRSKSSSNGGRKGSKGGSKGRPGSGSSIAGA	35	TT(1-35)	No entry found	Derived from Cathelicidins	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Unconventional feature	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. TT(1	[Ref.27818338]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=4¦ÌM);A. salmonicida (ATCC 33658)(MIC=2¦ÌM);Y. ruckeri (NCIMB 1315)(MIC=8¦ÌM);V. anguillarum (ATCC 43305 With addition of 2% NaCl)(MIC>32¦ÌM);A. hydrophila (ATCC 7966)(MIC>32¦ÌM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=16-8¦ÌM);L. garvieae (ATCC 49156)(MIC=1¦ÌM)	[Ref.27818338] No hemolytic activity to human;No hemolytic activity to trout	Linear	Free	Free	None	L	"[Ref.27818338] The cell viability of RTG-2 cells is 106%,  117%, 126% and 121.5% at peptide concentrations of 0.25, 1, 4, and 8 ¦ÌM."	Not found	27818338	Fish Shellfish Immunol. 2016 Dec;59:456-468. 	"D'Este F, Benincasa M, Cannone G, Furlan M, Scarsini M, Volpatti D, Gennaro R, Tossi A, Skerlavaj B, Scocchi M."	Antimicrobial and host cell-directed activities of Gly/Ser-rich peptides from salmonid cathelicidins.
DRAMP20861	KIRTRRSOARKOSRGNGGGIROPGGGIRLGGGSLIGR	37	STF(1-37)	No entry found	Derived from Cathelicidins	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Unconventional feature	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. The peptides inhibit the growth of V. anguillarum or A. hydrophila (MIC >32 	[Ref.27818338]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=2¦ÌM);A. salmonicida (ATCC 33658)(MIC=8-4¦ÌM);Y. ruckeri (NCIMB 1315)(MIC=16¦ÌM);V. anguillarum (ATCC 43305 With addition of 2% NaCl)(MIC>32¦ÌM);A. hydrophila (ATCC 7966)(MIC>32¦ÌM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=16-8¦ÌM);L. garvieae (ATCC 49156)(MIC=8¦ÌM)	[Ref.27818338] No hemolytic activity to human;No hemolytic activity to trout	Cyclic	Free	Free	Disulfide bond between Cys12 and Cys22.	L	"[Ref.27818338] The cell viability of RTG-2 cells is 108%,  112%, 117% and 118% at peptide concentrations of 0.25, 1, 4, and 8 ¦ÌM."	Not found	27818338	Fish Shellfish Immunol. 2016 Dec;59:456-468. 	"D'Este F, Benincasa M, Cannone G, Furlan M, Scarsini M, Volpatti D, Gennaro R, Tossi A, Skerlavaj B, Scocchi M."	Antimicrobial and host cell-directed activities of Gly/Ser-rich peptides from salmonid cathelicidins.
DRAMP20862	RRGKDSGGPKMGRKNSKGGWRGRPGSGRPGFGSGI	39	rtCATH2(5-40)	No entry found	Derived from Cathelicidins	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Unconventional feature	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria.The peptides inhibit the growth of V. anguillarum or A. hydrophila (MIC >32 	[Ref.27818338]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=16¦ÌM);A. salmonicida (ATCC 33658)(MIC=16¦ÌM);Y. ruckeri (NCIMB 1315)(MIC=16¦ÌM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=64¦ÌM)	[Ref.27818338] No hemolytic activity to human	Linear	Free	Free	None	L	[Ref.27818338] No cytotoxicity information found	Not found	27818338	Fish Shellfish Immunol. 2016 Dec;59:456-468. 	"D'Este F, Benincasa M, Cannone G, Furlan M, Scarsini M, Volpatti D, Gennaro R, Tossi A, Skerlavaj B, Scocchi M."	Antimicrobial and host cell-directed activities of Gly/Ser-rich peptides from salmonid cathelicidins.
DRAMP20863	KIRTRRGKDSGGPKMGRKNSKGGWRGRPGSGSRPGFGSGI	42	rtCATH2(1-40)	No entry found	Derived from Cathelicidins	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Unconventional feature	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. The peptides inhibit the growth of V. anguillarum or A. hydrophila (MIC >32 	[Ref.27818338]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=4¦ÌM);A. salmonicida (ATCC 33658)(MIC=8-4¦ÌM);Y. ruckeri (NCIMB 1315)(MIC=16¦ÌM);V. anguillarum (ATCC 43305 With addition of 2% NaCl)(MIC>32¦ÌM);A. hydrophila (ATCC 7966)(MIC>32¦ÌM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=16-8¦ÌM);L. garvieae (ATCC 49156)(MIC=16-8¦ÌM)	[Ref.27818338] No hemolytic activity to human;No hemolytic activity to trout	Linear	Free	Free	None	L	"[Ref.27818338] The cell viability of RTG-2 cells is 112.5%, 105%, 107%, 94% at peptide concentrations of 0.25, 1, 4, and 8 ¦ÌM."	Not found	27818338	Fish Shellfish Immunol. 2016 Dec;59:456-468. 	"D'Este F, Benincasa M, Cannone G, Furlan M, Scarsini M, Volpatti D, Gennaro R, Tossi A, Skerlavaj B, Scocchi M."	Antimicrobial and host cell-directed activities of Gly/Ser-rich peptides from salmonid cathelicidins.
DRAMP20864	KFRSNGRHGSGSRLGGGSLIGRPGGGS	27	SF(18-45)	No entry found	Derived from Cathelicidins	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Unconventional feature	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. SF(18	[Ref.27818338]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=16¦ÌM);A. salmonicida (ATCC 33658)(MIC=64¦ÌM);Y. ruckeri (NCIMB 1315)(MIC=32¦ÌM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=64¦ÌM)	[Ref.27818338] No hemolytic activity to human	Linear	Free	Free	None	L	[Ref.27818338] No cytotoxicity information found	Not found	27818338	Fish Shellfish Immunol. 2016 Dec;59:456-468. 	"D'Este F, Benincasa M, Cannone G, Furlan M, Scarsini M, Volpatti D, Gennaro R, Tossi A, Skerlavaj B, Scocchi M."	
DRAMP20865	(RRWQWR)2-K-(Ahx)	14	the dimeric RRWQWR motif peptide molecule	No entry found	Derived from bovine LfcinB6	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29984236] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=14 ¦Ìg/ml; MBC=110 ¦Ìg/ml), Staphylococcus aureus ATCC 33591 (MIC=55 ¦Ìg/ml; MBC=110 ¦Ìg/ml);##Gram-negative bacteria: Klebsiella pneumoniae ATCC 13883 (MIC=27 ¦Ìg/ml; MBC=55 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=27 ¦Ìg/ml; MBC=220 ¦Ìg/ml)"	"[Ref.29984236] 0% hemolysis at 5 ¦ÌM, 1% hemolysis at 12 ¦ÌM, 2% hemolysis at 22 ¦ÌM, 2% hemolysis at 50 ¦ÌM, 4% hemolysis at 100 ¦ÌM against human red blood cells"	Branched	Free	Amidation	None	L	[Ref.29984236] No cytotoxicity information found	Not found	29984236	Biomed Res Int. 2018 Jun 10;2018:5252891	"Sandra C. Vega Chaparro, J. Tatiana Valencia Salguero, Diana A. Mart¨ªnez Baquero, Jaiver E. Rosas P¨¦rez."	Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens.
DRAMP20866	(RRWQWR)4-K2-(Ahx)2-C2	30	the tetrameric RRWQWR motif peptide molecule	No entry found	Derived from bovine LfcinB6	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29984236] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=29 ¦Ìg/ml; MBC=57 ¦Ìg/ml), Staphylococcus aureus ATCC 33591 (MIC=57 ¦Ìg/ml; MBC=57 ¦Ìg/ml);##Gram-negative bacteria: Klebsiella pneumoniae ATCC 13883 (MIC=29 ¦Ìg/ml; MBC=115 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=57 ¦Ìg/ml; MBC=115 ¦Ìg/ml)"	"[Ref.29984236] 5% haemolysis at 5 ¦ÌM, 10% haemolysis at 12 ¦ÌM, 10% haemolysis at 22 ¦ÌM, 0% haemolysis at 50 ¦ÌM, 2% haemolysis at 100 ¦ÌM against human red blood cells"	Branched	Free	Amidation	Disulfide bond which links two dimeric motif peptides	L	[Ref.29984237] No cytotoxicity information found	Not found	29984236	Biomed Res Int. 2018 Jun 10;2018:5252891	"Sandra C. Vega Chaparro, J. Tatiana Valencia Salguero, Diana A. Mart¨ªnez Baquero, Jaiver E. Rosas P¨¦rez."	Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens.
DRAMP20867	RWQWRWQWR	9	the palindromic RRWQWR motif peptide molecule	No entry found	Derived from bovine LfcinB6	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29984236] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=74 ¦Ìg/ml; MBC=148 ¦Ìg/ml), Staphylococcus aureus ATCC 33591 (MIC=9 ¦Ìg/ml; MBC=74 ¦Ìg/ml);##Gram-negative bacteria: Klebsiella pneumoniae ATCC 13883 (MIC=74 ¦Ìg/ml; MBC=148 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=74 ¦Ìg/ml; MBC=148 ¦Ìg/ml)"	"[Ref.29984236] 0% haemolysis at 5 ¦ÌM, 1% haemolysis at 12 ¦ÌM, 0% haemolysis at 22 ¦ÌM, 5% haemolysis at 50 ¦ÌM, 25% haemolysis at 100 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.29984238] No cytotoxicity information found	Not found	29984236	Biomed Res Int. 2018 Jun 10;2018:5252891	"Sandra C. Vega Chaparro, J. Tatiana Valencia Salguero, Diana A. Mart¨ªnez Baquero, Jaiver E. Rosas P¨¦rez."	Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens.
DRAMP20868	KFKKLFKKLSPVIGKEFKRIVERIKRFLR	29	H4	No entry found	Derived from BMAP-27 and OP-145	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix 	The peptide adopts a conformational structure with 90 % alpha helix.	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29910626] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=20 ¦ÌM), Staphylococcus aureus ATCC 33591 (MIC=10 ¦ÌM), Staphylococcus aureus ATCC 43300 (MIC=10 ¦ÌM), Staphylococcus aureus ATCC BAA41 (MIC=10 ¦ÌM), Enterococcus faecalis ATCC 19433 (MIC=15 ¦ÌM), Enterococcus faecalis ATCC BAA2365 (MIC=5 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=10 ¦ÌM), Enterococcus faecium ATCC BAA2316 (MIC=5 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=20 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=10 ¦ÌM), Klebsiella pneumoniae ATCC 13883 (MIC=2.5 ¦ÌM), Pseudomonas aeruginosa ATCC BAA2114 (MIC=25 ¦ÌM), Escherichia coli ATCC BAA2452 (MIC=10 ¦ÌM)"	"[Ref.29910626] 0% haemolysis at 5 ¦ÌM, 0% haemolysis at 10 ¦ÌM, 0% haemolysis at 25 ¦ÌM, 0% haemolysis at 40 ¦ÌM, 0% haemolysis at 55 ¦ÌM, 0% haemolysis at 75 ¦ÌM, 0% haemolysis at 80 ¦ÌM, 2.1% haemolysis at 100 ¦ÌM against human red blood cells"	Linear	Free	Free	None	L	[Ref.29910626] IC50 = 61.9¡À0.18 ¦ÌM against HEK293.## IC50 = 64.9¡À1.01 ¦ÌM against Vero.	Not found	29910626	Infect Drug Resist. 2018 Jun 1;11:835-847. 	"Almaaytah A, Qaoud MT, Abualhaijaa A, Al-Balas Q, Alzoubi KH."	Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides.
DRAMP20869	GLLKRIKTL	9	Pal-ano-9 (Pal-anoplin peptide derivative)	No entry found	Derived from the peptide Pal-anoplin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. The peptide is palmitoylated.	[Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=0.406 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.406 ¦Ìg/mL);##Fungi: Candida albicans ATCC 10231 (MIC=3.25 ¦Ìg/mL).	[Ref.29614317] HC50=18.92¦Ìg/mL against human red blood cells	Linear	Acylation (Gly1 conjugated with a palmitoyl group)	Amidation	None	L	[Ref.29614317] No cytotoxicity information found	Not found	29614317	Peptides. 2018 Jun;104:7-14.	"Salas RL, Garcia JKDL, Miranda ACR, Rivera WL, Nellas RB, Sabido PMG."	Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin.
DRAMP20870	GLLKRIKT	8	Pal-ano-8 (Pal-anoplin peptide derivative)	No entry found	Derived from the peptide Pal-anoplin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Random coil	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. The peptide is palmitoylated.	[Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1.63 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.25 ¦Ìg/mL);##Fungi: Candida albicans ATCC 10231 (MIC=26 ¦Ìg/mL).	[Ref.29614317] HC50=33.74¦Ìg/mL against human red blood cells	Linear	Acylation (Gly1 conjugated with a palmitoyl group)	Amidation	None	L	[Ref.29614318] No cytotoxicity information found	Not found	29614317	Peptides. 2018 Jun;104:7-14.	"Salas RL, Garcia JKDL, Miranda ACR, Rivera WL, Nellas RB, Sabido PMG."	Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin.
DRAMP20871	GLLKRIK	7	Pal-ano-7 (Pal-anoplin peptide derivative)	No entry found	Derived from the peptide Pal-anoplin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Random coil	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. The peptide is palmitoylated.	[Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=0.813 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1.63 ¦Ìg/mL);##Fungi: Candida albicans ATCC 10231 (MIC=13 ¦Ìg/mL).	[Ref.29614317] HC50=37.70¦Ìg/mL against human red blood cells	Linear	Acylation (Gly1 conjugated with a palmitoyl group)	Amidation	None	L	[Ref.29614319] No cytotoxicity information found	Not found	29614317	Peptides. 2018 Jun;104:7-14.	"Salas RL, Garcia JKDL, Miranda ACR, Rivera WL, Nellas RB, Sabido PMG."	Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin.
DRAMP20872	GLLKRI	6	Pal-ano-6 (Pal-anoplin peptide derivative)	No entry found	Derived from the peptide Pal-anoplin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix 	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. The peptide is palmitoylated.	[Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=0.61 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.25 ¦Ìg/mL);##Fungi: Candida albicans ATCC 10231 (MIC=1.63 ¦Ìg/mL).	[Ref.29614317] HC50=7.51¦Ìg/mL against human red blood cells	Linear	Acylation (Gly1 conjugated with a palmitoyl group)	Amidation	None	L	[Ref.29614320] No cytotoxicity information found	Not found	29614317	Peptides. 2018 Jun;104:7-14.	"Salas RL, Garcia JKDL, Miranda ACR, Rivera WL, Nellas RB, Sabido PMG."	Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin.
DRAMP20873	GLLKR	5	Pal-ano-5 (Pal-anoplin peptide derivative)	No entry found	Derived from the peptide Pal-anoplin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Random coil	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. The peptide is palmitoylated.	[Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3.25 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.5 ¦Ìg/mL);##Fungi: Candida albicans ATCC 10231 (MIC=13 ¦Ìg/mL).	[Ref.29614317] HC50= 66.12¦Ìg/mL against human red blood cells	Linear	Acylation (Gly1 conjugated with a palmitoyl group)	Amidation	None	L	[Ref.29614321] No cytotoxicity information found	Not found	29614317	Peptides. 2018 Jun;104:7-14.	"Salas RL, Garcia JKDL, Miranda ACR, Rivera WL, Nellas RB, Sabido PMG."	Effects of truncation of the peptide chain on the secondary structure and bioactivities of palmitoylated anoplin.
DRAMP20874	SKVWRHWRRFWHRAHRKL	18	Chensinin-1b	No entry found	Derived from chensinin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, beta sheet and Random coil"	The peptide adopts a random coil structure in water and presents an ordered alpha-helix structure with 11.96 % beta-strands and 28.06 % alpha-helices in TFE solution	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Anticancer activities against HeLa cervical carcinoma and MCF-7 breast carcinoma.	"[Ref.29549839] Gram-positive bacteria: Staphylococcus aureus (MIC=3.13 ¦ÌM), Bacillus cereus (MIC=3.13 ¦ÌM), Streptococcus lactis (MIC=3.13 ¦ÌM), Enterococcus faecalis (MIC=1.56 ¦ÌM), Enterococcus faecium (MIC=3.13 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa (MIC=1.56 ¦ÌM);##cancer cells: HeLa cervical carcinoma (IC50=113.10¦Ì¡À¦Ì4.10 ¦ÌM), MCF-7 breast carcinoma (IC50=51.85¦Ì¡À¦Ì0.88 ¦ÌM)"	[Ref.29549839] HC50>500 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.29549839] No cytotoxicity information found	Cell membrane (disrupted the bacterial cell membranes through a 	29549839	Eur J Med Chem. 2018 Apr 25;150:546-558.	"Dong W, Liu Z, Sun L, Wang C, Guan Y, Mao X, Shang D."	Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails.
DRAMP20875	SKVWRHWRRFWHRAHRKL	18	OA-C1b	No entry found	Derived from Chensinin-1b	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, Random coil"	The peptide adopts a random coil structure in water and presents an ordered alpha-helix structure with 12.88 % beta-strands and 47.36 % alpha-helices in TFE solution	None	"Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Anticancer activities against HeLa cervical carcinoma, A375 melanoma and MCF-7 breast carcinoma. The peptide is a lipopeptide with CH3(CH2)6CO-."	"[Ref.29549839] Gram-positive bacteria: Staphylococcus aureus (MIC=3.13 ¦ÌM), Bacillus cereus (MIC=1.56 ¦ÌM), Streptococcus lactis (MIC=1.56 ¦ÌM), Enterococcus faecalis (MIC=1.56 ¦ÌM), Enterococcus faecium (MIC=1.56 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa (MIC=1.56 ¦ÌM);##cancer cells: HeLa cervical carcinoma (IC50=23.86¦Ì¡À¦Ì0.95 ¦ÌM), A375 melanoma (IC50=50.97¦Ì¡À¦Ì1.45 ¦ÌM), MCF-7 breast carcinoma (IC50=34.94¦Ì¡À¦Ì2.99 ¦ÌM)"	[Ref.29549839] HC50>500 ¦ÌM against human red blood cells	Linear	Acylation (Ser1 conjugated with octanoic acid)	Free	None	L	[Ref.29549839] No cytotoxicity information found	Not found	29549839	Eur J Med Chem. 2018 Apr 25;150:546-558.	"Dong W, Liu Z, Sun L, Wang C, Guan Y, Mao X, Shang D."	Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails.
DRAMP20876	SKVWRHWRRFWHRAHRKL	18	LA-C1b	No entry found	Derived from Chensinin-1b	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, Random coil"	The peptide adopts a random coil structure in water and presents an ordered alpha-helix structure with 6.31 % beta-strands and 32.16 % alpha-helices in TFE solution	None	"Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Anticancer activities against HeLa cervical carcinoma, A375 melanoma and MCF-7 breast carcinoma. The peptide is a lipopeptide with CH3(CH2)6CO-."	"[Ref.29549839] Gram-positive bacteria: Staphylococcus aureus (MIC=3.13 ¦ÌM), Bacillus cereus (MIC=3.13 ¦ÌM), Streptococcus lactis (MIC=3.13 ¦ÌM), Enterococcus faecalis (MIC=1.56 ¦ÌM), Enterococcus faecium (MIC=3.13 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa (MIC=1.56 ¦ÌM);##cancer cells: HeLa cervical carcinoma (IC50=20.38¦Ì¡À¦Ì0.28 ¦ÌM), A375 melanoma (IC50=21.25¦Ì¡À¦Ì1.51 ¦ÌM), MCF-7 breast carcinoma (IC50=25.77¦Ì¡À¦Ì2.02 ¦ÌM)"	[Ref.29549839] HC50>500 ¦ÌM against human red blood cells	Linear	Acylation (Ser1 conjugated with lauric acid)	Free	None	L	[Ref.29549839] No cytotoxicity information found	Not found	29549839	Eur J Med Chem. 2018 Apr 25;150:546-558.	"Dong W, Liu Z, Sun L, Wang C, Guan Y, Mao X, Shang D."	Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails.
DRAMP20877	SKVWRHWRRFWHRAHRKL	18	PA-C1b	No entry found	Derived from Chensinin-1b	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix, Random coil"	The peptide adopts a random coil structure in water and presents an ordered alpha-helix structure with 12.88 % beta-strands and 22.67 % alpha-helices in TFE solution	None	"Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Anticancer activities against HeLa cervical carcinoma, A375 melanoma and MCF-7 breast carcinoma. The peptide is a lipopeptide with CH3(CH2)6CO-."	"[Ref.29549839] Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ¦ÌM), Bacillus cereus (MIC=6.25 ¦ÌM), Streptococcus lactis (MIC=3.13 ¦ÌM), Enterococcus faecalis (MIC= 3.13 ¦ÌM), Enterococcus faecium (MIC= 6.25 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa (MIC=6.25 ¦ÌM);##cancer cells: HeLa cervical carcinoma (IC50=21.04¦Ì¡À¦Ì0.18 ¦ÌM), A375 melanoma (IC50=18.15¦Ì¡À¦Ì0.21 ¦ÌM), MCF-7 breast carcinoma (IC50=20.63¦Ì¡À¦Ì0.47 ¦ÌM)"	[Ref.29549839] HC50>500 ¦ÌM against human red blood cells	Linear	Acylation (Ser1 conjugated with palmitic acid)	Free	None	L	[Ref.29549839] No cytotoxicity information found	Not found	29549839	Eur J Med Chem. 2018 Apr 25;150:546-558.	"Dong W, Liu Z, Sun L, Wang C, Guan Y, Mao X, Shang D."	Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails.
DRAMP20878	MGFGCPEDEYECHNHCKNSVGCRGGYCDAGTLRQRCTCYGCNQKGRSIQE	50	rVpDef	No entry found	Derived from VpDef	ATGGGTTTTGGTTGTCCAGA	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29524591] Gram-positive bacteria: Listeria monocytogenes ATCC 21633 (MIC=75 ¦Ìg/ml), Bacillu subtilis Lzz-133 (MIC=95 ¦Ìg/ml), Staphylococcus aureus ATCC 25923 (MIC=120 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli O157 ATCC 35150 (MIC=50 ¦Ìg/ml), Eschericha coli ATCC 10305 (MIC=75 ¦Ìg/ml), Salmonella enterica ATCC 10467 (MIC=120 ¦Ìg/ml)"	"[Ref.29524591] 0% haemolysis at 30 ¦Ìg/ml, 0% haemolysis at 60 ¦Ìg/ml, 0% haemolysis at 90 ¦Ìg/ml, 0% haemolysis at 115 ¦Ìg/ml, 0.2% haemolysis at 145 ¦Ìg/ml, 1.5% haemolysis at 175 ¦Ìg/ml against rabbit red blood cells"	Linear	Free	Free	None	L	[Ref.29524591] No cytotoxicity information found	Not found	29524591	Protein Expr Purif. 2018 Jul;147:78-84. 	"Meng DM, Lv YJ, Zhao JF, Liu QY, Shi LY, Wang JP, Yang YH, Fan ZC."	Efficient production of a recombinant Venerupis philippinarum defensin (VpDef) in Pichia pastoris and characterization of its antibacterial activity and stability.
DRAMP20879	KWKIFKKIEKVGRNVRDGIIKAGPAVQVVGQATSIAK	37	DAN1	A0A212EJN7	Belongs to the cecropin family.	KGM_210268	Danaus plexippus (monarch butterfly)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Random coil	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29501691] Gram-positive bacteria: Bacillus subtilis (MIC=131.3¦Ì¡À¦Ì46.1 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli (MIC=4.9¦Ì¡À¦Ì2.3 ¦Ìg/mL), Pseudomonas aeruginosa (MIC=7¦Ì¡À¦Ì0.8 ¦Ìg/mL), Klebsiella pneumoniae (MIC=16.2¦Ì¡À¦Ì1.9 ¦Ìg/mL)"	"[Ref.29501691] 0% haemolysis at 10 ¦Ìg/ml, 0% haemolysis at 25 ¦Ìg/ml, 0% haemolysis at 50 ¦Ìg/ml, 0% haemolysis at 100 ¦Ìg/ml, 0% haemolysis at 200 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Amidation	None	L	[Ref.29501691] No cytotoxicity information found	Not found	29501691	Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017.	"Duwadi D, Shrestha A, Yilma B, Kozlovski I, Sa-Eed M, Dahal N, Jukosky J."	Identification and screening of potent antimicrobial peptides in arthropod genomes.
DRAMP20880	RWKFLKKIEKVGRKVRDGVIKAGPAVGVVGQATSIYK	37	DAN2	A0A212F3T6	Belongs to the?cecropin family.	KGM_210265	Monarch butterfly (Danaus plexippus)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Random coil	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29501691] Gram-positive bacteria: Bacillus subtilis (MIC=50¦Ì¡À¦Ì19 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli (MIC=2.1¦Ì¡À¦Ì0.7 ¦Ìg/mL), Pseudomonas aeruginosa (MIC=5¦Ì¡À¦Ì2.5 ¦Ìg/mL), Klebsiella pneumoniae (MIC=4.3¦Ì¡À¦Ì1.4 ¦Ìg/mL);##Fungi: Candida albicans  (MIC=72.5¦Ì¡À¦Ì35.2 ¦Ìg/mL)"	"[Ref.29501691] 0% haemolysis at 10 ¦Ìg/ml, 0% haemolysis at 25 ¦Ìg/ml, 0% haemolysis at 50 ¦Ìg/ml, 0% haemolysis at 100 ¦Ìg/ml, 0% haemolysis at 200 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Amidation	None	L	[Ref.29501691] No cytotoxicity information found	Not found	29501691	Peptides. 2018 May;103:26-30. doi: 10.1016/j.peptides.2018.01.017.	"Duwadi D, Shrestha A, Yilma B, Kozlovski I, Sa-Eed M, Dahal N, Jukosky J."	Identification and screening of potent antimicrobial peptides in arthropod genomes.
DRAMP20883	KRFKKFFRKLKKSVKKRKKEFKKKPRVIKVSIPF	34	Cath-A	No entry found	Derived from three-finger toxin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29392557] Gram-positive bacteria: MRSA PS-2 (MIC=64 ¦Ìg/ml);##Gram-negative bacteria, MRSA PS-7 (MIC=64 ¦Ìg/ml), MRSA PS-18 (MIC=32 ¦Ìg/ml), MRSA PS-45 (MIC=32 ¦Ìg/ml), MRSA PS-46 (MIC=32 ¦Ìg/ml), MRSA PS-50 (MIC=32 ¦Ìg/ml), MRSA PS-59 (MIC=64 ¦Ìg/ml), MRSA PS-70 (MIC=32 ¦Ìg/ml), MRSA PS-84 (MIC=128 ¦Ìg/ml), MRSA PS-106 (MIC=32 ¦Ìg/ml), MRSA PS-131 (MIC=128 ¦Ìg/ml), MRSA PS-139 (MIC=32 ¦Ìg/ml), MRSA PS-162 (MIC=128 ¦Ìg/ml), MRSA PS-165 (MIC=32 ¦Ìg/ml), Staphylococcus aureus ATCC 25923 (MIC=32 ¦Ìg/ml), Staphylococcus aureus ATCC 33591 (MIC=128 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 ¦Ìg/ml), Escherichia coli ATCC 51446 (MIC=16 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=64 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=16 ¦Ìg/ml)"	"[Ref.29392557] 0% haemolysis at 1.0 ¦Ìg/ml, 0% haemolysis at 2.0 ¦Ìg/ml, 0% haemolysis at 4.0 ¦Ìg/ml, 0% haemolysis at 8.0 ¦Ìg/ml, 0% haemolysis at 16.0 ¦Ìg/ml, 0% haemolysis at 31.2 ¦Ìg/ml, 2% haemolysis at 62.5 ¦Ìg/ml, 4% haemolysis at 125.0 ¦Ìg/ml, 15% haemolysis at 250.0 ¦Ìg/ml, 23% haemolysis at 500.0 ¦Ìg/ml, 53% haemolysis  at 1000.0 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.29392557] The cell viability of HUVEC is 132%, 99% and 79%  at peptide concentrations of 35.5, 71 and 113 ¦Ìg/ml .## The cell viability of H9c2is 129%, 97%, and 80% at peptide concentrations of 35.5, 71, and 113 ¦Ìg/ml ."	Not found	29392557	J Microbiol. 2018 Feb;56(2):128-137.	"Tajbakhsh M, Karimi A, Tohidpour A, Abbasi N, Fallah F, Akhavan MM."	The antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus.
DRAMP20884	KRFKKFFRKLKKSVKKRKKEFKKKPRVIGVSIPF	34	Cath-B	No entry found	Derived from three-finger toxin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	"[Ref.29392557] Gram-positive bacteria: MRSA PS-2 (MIC=256 ¦Ìg/ml);##Gram-negative bacteria, MRSA PS-7 (MIC=32 ¦Ìg/ml), MRSA PS-18 (MIC=128 ¦Ìg/ml), MRSA PS-45 (MIC=64 ¦Ìg/ml), MRSA PS-46 (MIC=128 ¦Ìg/ml), MRSA PS-50 (MIC=128 ¦Ìg/ml), MRSA PS-59 (MIC=32 ¦Ìg/ml), MRSA PS-84 (MIC=128 ¦Ìg/ml), MRSA PS-131 (MIC=64 ¦Ìg/ml), MRSA PS-139 (MIC=64 ¦Ìg/ml), MRSA PS-162 (MIC=256 ¦Ìg/ml), MRSA PS-165 (MIC=128 ¦Ìg/ml), Staphylococcus aureus ATCC 25923 (MIC=32 ¦Ìg/ml), Staphylococcus aureus ATCC 33591 (MIC=256 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ¦Ìg/ml), Escherichia coli ATCC 51446 (MIC=8 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=32 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=8 ¦Ìg/ml)"	"[Ref.29392557] 0% haemolysis at 1.0 ¦Ìg/ml, 0% haemolysis at 2.0 ¦Ìg/ml, 0% haemolysis at 4.0 ¦Ìg/ml, 0% haemolysis at 8.0 ¦Ìg/ml, 3% haemolysis at 16.0 ¦Ìg/ml, 3% haemolysis at 31.2 ¦Ìg/ml, 3% haemolysis at 62.5 ¦Ìg/ml, 3% haemolysis at 125.0 ¦Ìg/ml, 3% haemolysis at 250.0 ¦Ìg/ml, 4% haemolysis at 500.0 ¦Ìg/ml, 5% haemolysis at 1000.0 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.29392557] The cell viability of HUVEC is 118%, 100% and 75% at peptide concentrations of 35.5 ¦Ìg/ml, 71 ¦Ìg/ml and 113 ¦Ìg/ml.## The cell viability of H9c2 is 123%, 97%, and 88% at peptide concentrations of 35.5, 71, and 113 ¦Ìg/ml."	Not found	29392557	J Microbiol. 2018 Feb;56(2):128-137.	"Tajbakhsh M, Karimi A, Tohidpour A, Abbasi N, Fallah F, Akhavan MM."	The antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus.
DRAMP20885	ILKKLWEGVKSI	12	Hp1404-T1a	No entry found	Derived from Hp1404	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix	The peptide adopts an alpha-helical conformation in the membrane-mimicking environments and adopts a random coil conformation in the presence of all liposome types .	None	Function: Antibacterial activity against the Gram-negative bacteria. 	"[Ref.29379033] Gram-negative bacteria: Pseudomonas aeruginosa 431 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 434 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 3399 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 3592 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 3904 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 4891 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 671973 (MIC=25 ¦ÌM)"	"[Ref.29379033] Hp1404-T1a does not induce substantial hemolysis, even at the high tested concentration (200¦Ì¦ÌM) against mouse red blood cells"	Linear	Free	Amidation	None	L	[Ref.29379033] No cytotoxicity information found	Lipopolysaccharide (LPS)-binding	29379033	Sci Rep. 2018 Jan 29;8(1):1763. 	"Kim MK, Kang HK, Ko SJ, Hong MJ, Bang JK, Seo CH, Park Y."	Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa.
DRAMP20886	ILKKLLEGVKSI	12	Hp1404-T1b	No entry found	Derived from Hp1404	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix	The peptide adopts an alpha-helical conformation in the membrane-mimicking environments and adopts a random coil conformation in the presence of all liposome types .	None	Function: Antibacterial activity against the Gram-negative bacteria. 	"[Ref.29379033] Gram-negative bacteria: Pseudomonas aeruginosa 434 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 3592 (MIC=25 ¦ÌM)"	"[Ref.29379033] Hp1404-T1b does not induce substantial hemolysis, even at the high tested concentration (200¦Ì¦ÌM) against mouse red blood cells"	Linear	Free	Amidation	None	L	[Ref.29379033] No cytotoxicity information found	Lipopolysaccharide (LPS)-binding	29379033	Sci Rep. 2018 Jan 29;8(1):1763. 	"Kim MK, Kang HK, Ko SJ, Hong MJ, Bang JK, Seo CH, Park Y."	Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa.
DRAMP20887	KLIPILSKTIPAGKNLFYKI	20	NCP-2 (CTX-1 peptide derivative)	No entry found	Derived from CTX-1	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	"The peptide adopts a conformational structure with 20 % alpha helix, 25 % beta sheet and 35 % random coil in the presence of DMPE-DMPG mixed vesicles."	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29364903] Gram-positive bacteria: Staphylococcus aureus ATCC 22953 (MBC=50 ¦Ìg/ml), Streptococcus agalactiae ATCC 13813 (MBC=12.5 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MBC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=12.5 ¦Ìg/ml), Acinetobacter baumannii (herpetological, cloacal) (MBC=1.6 ¦Ìg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=50 ¦Ìg/ml), Acinetobacter baumannii (human, urinary) (MBC=1.6 ¦Ìg/ml), Moraxella catarrhalis ATCC 25238 (MBC=1.6 ¦Ìg/ml);##Fungi: Candida albicans ATCC 10231 (MBC=50 ¦Ìg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=6.3 ¦Ìg/mL)"	"[Ref.29364903] 2% haemolysis at 12.5 ¦Ìg/ml, 8% haemolysis at 100.0 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Free	None	L	[Ref.29364903] The cell death rate of Madin-Darby Bovine Kidney(MDBK) cells is 3 % and 5% at peptide concentrations of 12.5 and 100  ¦Ìg/ml	Not found	29364903	PLoS One. 2018 Jan 24;13(1):e0190778. 	"Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, Taddei S."	Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity.
DRAMP20888	KLIWILSKTIPAGKNLFYKI	20	NCP-3 (CTX-1 peptide derivative)	No entry found	Derived from CTX-1	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	The peptide adopts a conformational structure with 43 % beta sheet and 35 % random coil in the presence of DMPE-DMPG mixed vesicles.	None	"Function: Antimicrobial activity against the Gram-positive bacteria, Gram-negative bacteria and fungi. NCP-3 completely inhibits the viral activity of BoHV-1 on MDBK cells at the concentration of 25 "	"[Ref.29364903] Gram-positive bacteria: Methicillin-resistant Staphylococcus aureus ATCC 43300 (MBC=6.3 ¦Ìg/ml), Staphylococcus aureus ATCC 22953 (MBC=1.6 ¦Ìg/ml), Enterococcus hirae ATCC 10541 (MBC=1.6 ¦Ìg/ml), Streptococcus agalactiae ATCC 13813 (MBC=1.6 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MBC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=12.5 ¦Ìg/ml), Acinetobacter baumannii (herpetological, cloacal) (MBC=1.6 ¦Ìg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=6.3 ¦Ìg/ml), Acinetobacter baumannii (human, urinary) (MBC=1.6 ¦Ìg/ml), Klebsiella pneumoniae subsp. pneumoniae (herpetological, cloacal) (MBC=50 ¦Ìg/ml), Enterobacter cloacae (herpetological, cloacal) (MBC=25 ¦Ìg/ml), Burkholderia cepacia ATCC 17759 (MBC=50 ¦Ìg/ml), Moraxella catarrhalis ATCC 25238 (MBC=1.6 ¦Ìg/ml);##Fungi: Candida albicans ATCC 10231 (MBC=12.5 ¦Ìg/mL), Candida glabrata ATCC 90030 (MBC=50 ¦Ìg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=6.3 ¦Ìg/mL)."	"[Ref.29364903] 3% haemolysis at 12.5 ¦Ìg/ml, 9% haemolysis at 100.0 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Free	None	L	[Ref.29364903] The cell death rate of Madin-Darby Bovine Kidney(MDBK) cells is 3 % and 7% at peptide concentrations of 12.5 and 100  ¦Ìg/ml	Not found	29364903	PLoS One. 2018 Jan 24;13(1):e0190778. 	"Sala A, Cabassi CS, Santospirito D, Polverini E, Flisi S, Cavirani S, Taddei S."	Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity.
DRAMP20893	FIHHIIGGLFSAGKAAHRLIRRRRR	25	I16A	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=64 ¦Ìg/ml; MBC=128 ¦Ìg/ml), Methicillin-resistant Staphylococcus aureus (MIC=64 ¦Ìg/ml; MBC=512 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 ¦Ìg/ml; MBC>512 ¦Ìg/ml);##Fungi: Candida albicans (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml)"	"[Ref.29040295] 10% haemolysis at 6.25 ¦Ìg/ml, 20% haemolysis at 12.50 ¦Ìg/ml, 35% haemolysis at 25.00 ¦Ìg/ml, 80% haemolysis at 50.00 ¦Ìg/ml, 95% haemolysis at 100.00 ¦Ìg/ml, 100% haemolysis at 200.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20894	FIHHIIGGLFSAGKAIHRHHRRRRR	25	L19H/I20H	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=128 ¦Ìg/ml; MBC=512 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 ¦Ìg/ml; MBC>512 ¦Ìg/ml);##Fungi: Candida albicans (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml)	"[Ref.29040295] 10% haemolysis at 6.25 ¦Ìg/ml, 13% haemolysis at 12.50 ¦Ìg/ml, 16% haemolysis at 25.00 ¦Ìg/ml, 40% haemolysis at 50.00 ¦Ìg/ml, 85% haemolysis at 100.00 ¦Ìg/ml, 100% haemolysis at 200.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20895	AAHHIIGGLFSAGKAIHRLIRRRRR	25	F1A/I2A	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=128 ¦Ìg/ml; MBC=256 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 ¦Ìg/ml; MBC=256 ¦Ìg/ml);##Fungi: Candida albicans (MIC=64 ¦Ìg/ml; MBC=128 ¦Ìg/ml)	"[Ref.29040295] 10% haemolysis at 12.50 ¦Ìg/ml,  15% haemolysis at 25.00 ¦Ìg/ml,  30% haemolysis at 50.00 ¦Ìg/ml,  90% haemolysis at 100.00 ¦Ìg/ml,  95% haemolysis at 200.00 ¦Ìg/ml,  100% haemolysis at 400.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20899	FIHHAAGGLFSAGKAIHRLIRRRRR	25	I5A/I6A	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria. Antifungal activity.	[Ref.29040295] Gram-negative bacteria: Pseudomonas aeruginosa (MIC=512 ¦Ìg/ml; MBC=512 ¦Ìg/ml);##Fungi: Candida albicans (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml)	"[Ref.29040295] 5% haemolysis at 25.00 ¦Ìg/ml,  7% haemolysis at 50.00 ¦Ìg/ml,  10% haemolysis at 100.00 ¦Ìg/ml,  40% haemolysis at 200.00 ¦Ìg/ml,  80% haemolysis at 400.00 ¦Ìg/ml,  100% haemolysis at 800.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20900	FIHHIIGGLFSIGKIIHRLIRRRRR	25	A12I/A15I	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=16 ¦Ìg/ml; MBC=64 ¦Ìg/ml), Methicillin-resistant Staphylococcus aureus (MIC=64 ¦Ìg/ml; MBC=256 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=512 ¦Ìg/ml; MBC>512 ¦Ìg/ml);##Fungi: Candida albicans (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml)"	"[Ref.29040295] 0% haemolysis at 0.20 ¦Ìg/ml,  5% haemolysis at 0.39 ¦Ìg/ml,  25% haemolysis at 0.78 ¦Ìg/ml,  85% haemolysis at 1.56 ¦Ìg/ml,  95% haemolysis at 3.13 ¦Ìg/ml,  100% haemolysis at 6.25 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20901	FIHHIIGGLFSVGKHIHRLIRRRRR	25	A12V/A15H	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=16 ¦Ìg/ml; MBC=16 ¦Ìg/ml), Methicillin-resistant Staphylococcus aureus (MIC=32 ¦Ìg/ml; MBC=64 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml);##Fungi: Candida albicans (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml)"	"[Ref.29040295] 0% haemolysis at 0.78 ¦Ìg/ml,  10% haemolysis at 1.56 ¦Ìg/ml,  55% haemolysis at 3.13 ¦Ìg/ml,  85% haemolysis at 6.25 ¦Ìg/ml,  98% haemolysis at 12.50 ¦Ìg/ml,  100% haemolysis at 25.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20903	FIHHIIGGLFSAGKAIHRLIRRR	23	dC2	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=16 ¦Ìg/ml; MBC=32 ¦Ìg/ml), Methicillin-resistant Staphylococcus aureus (MIC=32 ¦Ìg/ml; MBC=32 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=512 ¦Ìg/ml; MBC>512 ¦Ìg/ml);##Fungi: Candida albicans (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml)"	"[Ref.29040295] 2% haemolysis at 3.13 ¦Ìg/ml,  5% haemolysis at 6.25 ¦Ìg/ml,  25% haemolysis at 12.50 ¦Ìg/ml,  65% haemolysis at 25.00 ¦Ìg/ml,  90% haemolysis at 50.00 ¦Ìg/ml,  100% haemolysis at 100.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20904	FIHHIIGGLFSAGKAIHSLIHRRRR	25	R18S/R21H	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=32 ¦Ìg/ml; MBC=64 ¦Ìg/ml), Methicillin-resistant Staphylococcus aureus (MIC=32 ¦Ìg/ml; MBC=32 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 ¦Ìg/ml; MBC=512 ¦Ìg/ml);##Fungi: Candida albicans (MIC=256 ¦Ìg/ml; MBC=512 ¦Ìg/ml)"	"[Ref.29040295] 8% haemolysis at 6.25 ¦Ìg/ml,  10% haemolysis at 12.50 ¦Ìg/ml,  15% haemolysis at 25.00 ¦Ìg/ml,  40% haemolysis at 50.00 ¦Ìg/ml,  80% haemolysis at 100.00 ¦Ìg/ml,  100% haemolysis at 200.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20906	HHIIGGLFSAGKAIHRLIRRRRR	23	dN2	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=512 ¦Ìg/ml; MBC=512 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=512 ¦Ìg/ml; MBC>512 ¦Ìg/ml);##Fungi: Candida albicans (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml)	"[Ref.29040295] 5% haemolysis at 12.50 ¦Ìg/ml,  5% haemolysis at 25.00 ¦Ìg/ml,  20% haemolysis at 50.00 ¦Ìg/ml,  65% haemolysis at 100.00 ¦Ìg/ml,  90% haemolysis at 200.00 ¦Ìg/ml,  100% haemolysis at 400.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20907	IIGGLFSAGKAIHRLIRRRRR	21	dN4	No entry found	Derived from TP4	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=128 ¦Ìg/ml; MBC=128 ¦Ìg/ml), Methicillin-resistant Staphylococcus aureus (MIC=64 ¦Ìg/ml; MBC=256 ¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 ¦Ìg/ml; MBC>512 ¦Ìg/ml);##Fungi: Candida albicans (MIC=64 ¦Ìg/ml; MBC=128 ¦Ìg/ml)"	"[Ref.29040295] 10% haemolysis haemolysis at 12.50 ¦Ìg/ml,  12% haemolysis haemolysis at 25.00 ¦Ìg/ml,  20% haemolysis haemolysis at 50.00 ¦Ìg/ml,  35% haemolysis haemolysis at 100.00 ¦Ìg/ml,  75% haemolysis haemolysis at 200.00 ¦Ìg/ml,  100% haemolysis haemolysis at 400.00 ¦Ìg/ml,  100% haemolysis haemolysis at 800.00 ¦Ìg/ml against mouse red blood cells"	Linear	Free	Free	None	L	[Ref.29040295] No cytotoxicity information found	Not found	29040295	PLoS One. 2017 Oct 17;12(10):e0186442. 	"Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD."	"Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4."
DRAMP20910	FLGGLIKPWWPWRR	14	RN7-IN7(designed based on indolicidin and ranalexin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria.	"[Ref.26046345] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=31.25¦Ìg/ml), Pseudomonas aeruginosa ATCC 15442(MIC=62.5¦Ìg/ml), Acinetobacter baumanii ATCC 15308(MIC=125¦Ìg/ml), citrobacter spp(MIC>250¦Ìg/ml), Klebsiella pneumoniae(MIC>250¦Ìg/ml) ;## Gram-positive bacteria: Streptococcus pneumoniae(30 clinical isolates)(MIC=31.25-62.5¦Ìg/ml), Staphylococcus aureus ATCC 25923(MIC=31.25¦Ìg/ml), Methicillin resistant Staphylococcus aureus (MRSA)(MIC=31.25¦Ìg/ml), Enterococcus cloacae(MIC>250¦Ìg/ml), "	[Ref.26046345] The hemolytic activities of RN7-IN7 is 0.0% at 15.62¦Ìg/ml against human RBCs.	Linear	Free	Amidation	None	L	"[Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 62.5 ¦Ìg/ml. The cell viability of NL-20 is 95%, 92% and 6% at peptide concentrations of 62.5, 125 and 250 ¦Ìg/ml.## The cell viability of WRL-68 cell line is not affected("	Not found	26046345	PLoS One. 2015 Jun 5;10(6):e0128532. 	"Jindal HM, Le CF, Mohd Yusof MY, Velayuthan RD, Lee VS, Zain SM, Isa DM, Sekaran SD."	Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae.
DRAMP20912	FLGGLIKKWPWWPWRR	16	RN7-IN9(designed based on indolicidin and ranalexin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria.	"[Ref.26046345] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=7.81¦Ìg/ml), Pseudomonas aeruginosa ATCC 15442(MIC=31.25¦Ìg/ml), Acinetobacter baumanii ATCC 15308(MIC=31.25¦Ìg/ml), citrobacter spp(MIC>250¦Ìg/ml), Klebsiella pneumoniae(MIC>250¦Ìg/ml) ;## Gram-positive bacteria: Streptococcus pneumoniae(30 clinical isolates)(MIC=7.81¨C15.62¦Ìg/ml), Staphylococcus aureus ATCC 25923(MIC=7.81¦Ìg/ml), Methicillin resistant Staphylococcus aureus (MRSA)(MIC=7.81¦Ìg/ml), Enterococcus cloacae(MIC>250¦Ìg/ml), "	[Ref.26046345] The hemolytic activities of RN7-IN7 is 0.0% at 15.62¦Ìg/ml against human RBCs.	Linear	Free	Amidation	None	L	"[Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 31.25 ¦Ìg/ml. The cell viability of NL-20 is 51%, 13% and 7% at peptide concentrations of 62.5, 125 and 250 ¦Ìg/ml.## The cell viability of WRL-68 cell line is not affected"	Not found	26046345	PLoS One. 2015 Jun 5;10(6):e0128532.	"Jindal HM, Le CF, Mohd Yusof MY, Velayuthan RD, Lee VS, Zain SM, Isa DM, Sekaran SD."	Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae.
DRAMP20913	AIHDILKYGKPS	12	Myxinidin (G1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC >50 microM), Pseudomonas aeruginosa (MIC =10 microM), S. Salmonella typhimurium (MIC =3 microM), Klebsiella pneumoniae (MIC >50 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =10 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 3%, 5% and 10% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20914	GAHDILKYGKPS	12	Myxinidin (I2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC >50 microM), Pseudomonas aeruginosa (MIC >50 microM), S. Salmonella typhimurium (MIC >50 microM), Klebsiella pneumoniae (MIC >50 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =30 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 6%, 6.6% and 15.5% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20915	GIADILKYGKPS	12	Myxinidin (H3)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC >50 microM), Pseudomonas aeruginosa (MIC =15 microM), S. Salmonella typhimurium (MIC =10 microM), Klebsiella pneumoniae (MIC =30 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =20 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 4.9%,12%  and 20% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20916	GIHAILKYGKPS	12	Myxinidin (D4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC >50 microM), Pseudomonas aeruginosa (MIC >50 microM), S. Salmonella typhimurium (MIC >50 microM), Klebsiella pneumoniae (MIC =30 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =5 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 10%, 29.9%  and 34.9% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20917	GIHDALKYGKPS	12	Myxinidin (I5)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC =20 microM), Pseudomonas aeruginosa (MIC =10 microM), S. Salmonella typhimurium (MIC =4 microM), Klebsiella pneumoniae (MIC =20 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =20 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 4%, 11.7%  and 20% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90.	"Cantisani M1, Finamore E2, Mignogna E2, Falanga A3, Nicoletti GF4, Pedone C3, Morelli G3, Leone M5, Galdiero M6, Galdiero S7."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20918	GIHDIAKYGKPS	12	Myxinidin (L6)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC >50 microM), Pseudomonas aeruginosa (MIC >50 microM), S. Salmonella typhimurium (MIC >50 microM), Klebsiella pneumoniae (MIC =20 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =5 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 8%, 19.9%  and 29.9% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90.	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20919	GIHDILAYGKPS	12	Myxinidin (K7)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.2495783[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC =15 microM), Pseudomonas aeruginosa (MIC =15 microM), S. Salmonella typhimurium (MIC =15 microM), Klebsiella pneumoniae (MIC =20 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =10 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 2%, 5.7%  and 14% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20920	GIHDILKAGKPS	12	Myxinidin (Y8)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC =20 microM), Pseudomonas aeruginosa (MIC >50 microM), S. Salmonella typhimurium (MIC >50 microM), Klebsiella pneumoniae (MIC =20 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =10 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 3%  and 10% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20921	GIHDILKYAKPS	12	Myxinidin (G9)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC =5 microM), Pseudomonas aeruginosa (MIC =15 microM), S. Salmonella typhimurium (MIC =10 microM), Klebsiella pneumoniae (MIC =10 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =10 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 0.7%, 4.9%  and 15% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20922	GIHDILKYGAPS	12	Myxinidin (K10)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC =15 microM), Pseudomonas aeruginosa (MIC >50 microM), S. Salmonella typhimurium (MIC >50 microM), Klebsiella pneumoniae (MIC =10 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =20 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 2%, 7%  and 12% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20923	GIHDILKYGKAS	12	Myxinidin (P11)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC >50 microM), Pseudomonas aeruginosa (MIC =30 microM), S. Salmonella typhimurium (MIC =10 microM), Klebsiella pneumoniae (MIC =30 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =10 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 4.9%, 12%  and 9.9% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20924	GIHDILKYGKPA	12	Myxinidin (S12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC >50 microM), Pseudomonas aeruginosa (MIC >50 microM), S. Salmonella typhimurium (MIC >50 microM), Klebsiella pneumoniae (MIC =30 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC >50 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	"[Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 7%, 14.9%  and 19.9% at peptide concentrations of 1, 20, 50, 100 and 200 ¦ÌM."	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90. 	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20925	GIRDILKYGKPS	12	MH3R	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-nagative and Gram-positive bacteria.	"[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC =5 microM), Pseudomonas aeruginosa (MIC =20 microM), S. Salmonella typhimurium (MIC =5 microM), Klebsiella pneumoniae (MIC =5 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =10 microM)"	"[Ref.24957834] Some peptides at 50 ¦ÌM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 ¦ÌM and 200 ¦ÌM peptide."	Linear	Free	Amidation	None	L	[Ref.24957834] No cytotoxicity information found	Not found	24957834	Antimicrob Agents Chemother. 2014 Sep;58(9):5280-90.	"Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S."	Structural insights into and activity analysis of the antimicrobial peptide myxinidin.
DRAMP20926	LLPWKWPWWKWRR	13	IN1(designed based on indolicidin and ranalexin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function: Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria.	"[Ref.26046345] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=31.25¦Ìg/ml), Pseudomonas aeruginosa ATCC 15442(MIC=31.25¦Ìg/ml), Acinetobacter baumanii ATCC 15308(MIC>250¦Ìg/ml), citrobacter spp(MIC>250¦Ìg/ml), Klebsiella pneumoniae(MIC>250¦Ìg/ml) ;## Gram-positive bacteria: Streptococcus pneumoniae(30 clinical isolates)(MIC=31.25¨C62.5¦Ìg/ml), Staphylococcus aureus ATCC 25923(MIC=31.25¦Ìg/ml), Methicillin resistant Staphylococcus aureus (MRSA)(MIC=31.25¦Ìg/ml), Enterococcus cloacae(MIC>250¦Ìg/ml), "	[Ref.26046345] The hemolytic activities of IN1 is 3.6% at 250¦Ìg/ml against human RBCs.	Linear	Free	Amidation	None	L	[Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 62.5 ¦Ìg/ml. The cell viability of NL-20 is 37% and 17% at peptide concentrations of 125 and 250 ¦Ìg/ml.## The cell viability of WRL-68 cell line is not affected (<10%) bel	Not found	26046345	PLoS One. 2015 Jun 5;10(6):e0128532. 	"Jindal HM, Le CF, Mohd Yusof MY, Velayuthan RD, Lee VS, Zain SM, Isa DM, Sekaran SD."	Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae.
DRAMP20927	RRPWRWPWWPWRR	13	IN2(designed based on indolicidin and ranalexin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria.	"[Ref.26046345] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=31.25¦Ìg/ml), Pseudomonas aeruginosa ATCC 15442(MIC=31.25¦Ìg/ml), Acinetobacter baumanii ATCC 15308(MIC>250¦Ìg/ml), citrobacter spp(MIC>250¦Ìg/ml), Klebsiella pneumoniae(MIC>250¦Ìg/ml) ;## Gram-positive bacteria: Streptococcus pneumoniae(30 clinical isolates)(MIC=31.25¨C62.5¦Ìg/ml), Staphylococcus aureus ATCC 25923(MIC=31.25¦Ìg/ml), Methicillin resistant Staphylococcus aureus (MRSA)(MIC=31.25¦Ìg/ml), Enterococcus cloacae(MIC>250¦Ìg/ml), "	[Ref.26046345] IN2 showed 15.39% hemolytic activity at concentration of 250¦Ìg/ml against human RBCs.	Linear	Free	Amidation	None	L	[Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 62.5 ¦Ìg/ml. The cell viability of NL-20 is 40% and 19% at peptide concentrations of 125 and 250 ¦Ìg/ml.## The cell viability of WRL-68 cell line is not affected (<10%) bel	Not found	26046345	PLoS One. 2015 Jun 5;10(6):e0128532. 	"Jindal HM, Le CF, Mohd Yusof MY, Velayuthan RD, Lee VS, Zain SM, Isa DM, Sekaran SD."	Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae.
DRAMP20928	RRPWRWPRWPWRR	13	IN3(designed based on indolicidin and ranalexin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria.	"[Ref.26046345] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=31.25¦Ìg/ml), Pseudomonas aeruginosa ATCC 15442(MIC=31.25¦Ìg/ml), Acinetobacter baumanii ATCC 15308(MIC>250¦Ìg/ml), citrobacter spp(MIC>250¦Ìg/ml), Klebsiella pneumoniae(MIC>250¦Ìg/ml) ;## Gram-positive bacteria: Streptococcus pneumoniae(30 clinical isolates)(MIC=62.5¦Ìg/ml), Staphylococcus aureus ATCC 25923(MIC=31.25¦Ìg/ml), Methicillin resistant Staphylococcus aureus (MRSA)(MIC=62.5¦Ìg/ml), Enterococcus cloacae(MIC>250¦Ìg/ml), "	[Ref.26046345] The hemolytic activities of IN3 is 2.39% at 250¦Ìg/ml against human RBCs.	Linear	Free	Amidation	None	L	[Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 62.5 ¦Ìg/ml. The cell viability of NL-20 is 93% and 26% at peptide concentrations of 125 and 250 ¦Ìg/ml.## The cell viability of WRL-68 cell line is not affected (<10%) bel	Not found	26046345	PLoS One. 2015 Jun 5;10(6):e0128532. 	"Jindal HM, Le CF, Mohd Yusof MY, Velayuthan RD, Lee VS, Zain SM, Isa DM, Sekaran SD."	Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae.
DRAMP20929	FLGGLIKWWPWRR	13	RN7-IN6(designed based on indolicidin and ranalexin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria.	"[Ref.26046345] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=7.81¦Ìg/ml), Pseudomonas aeruginosa ATCC 15442(MIC=31.25¦Ìg/ml), Acinetobacter baumanii ATCC 15308(MIC>31.25¦Ìg/ml), citrobacter spp(MIC>250¦Ìg/ml), Klebsiella pneumoniae(MIC>250¦Ìg/ml) ;## Gram-positive bacteria: Streptococcus pneumoniae(30 clinical isolates)(MIC=7.81¨C15.62¦Ìg/ml), Staphylococcus aureus ATCC 25923(MIC=7.81¦Ìg/ml), Methicillin resistant Staphylococcus aureus (MRSA)(MIC=7.81¦Ìg/ml), Enterococcus cloacae(MIC>250¦Ìg/ml), "	[Ref.26046345] The hemolytic activities of RN7-IN6 is 0.0% at 15.62¦Ìg/ml against human RBCs. 	Linear	Free	Amidation	None	L	"[Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 31.25 ¦Ìg/ml. The cell viability of NL-20 is 70%, 6% and 8% at peptide concentrations of 62.5, 125 and 250 ¦Ìg/ml.## The cell viability of WRL-68 cell line is not affected "	Not found	26046345	PLoS One. 2015 Jun 5;10(6):e0128532. 	"Jindal HM, Le CF, Mohd Yusof MY, Velayuthan RD, Lee VS, Zain SM, Isa DM, Sekaran SD."	Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae.
DRAMP20930	KKLFKKILKYLA	12	BP100-Ala-NH-C16H33	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Alpha helix	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.29750913] Gram-negative bacteria:Escherichia coli(ATCC 25922)(MIC=16¦ÌM);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=8¦ÌM);Bacillus subtilis(PY79)(MIC=8¦ÌM)	[Ref.29750913] C50 =6.3¦ÌM against human red blood cells	Linear	Free	"Amidation and Acylation (-NH-C??H??, conjugated with a n?hexadecyl acyl chain)"	None	L	[Ref.29750913] No cytotoxicity information found	Not found	29750913	Biochim Biophys Acta. 2018 Aug;1860(8):1502-1516. 	"Carretero GPB, Saraiva GKV, Cauz ACG, Rodrigues MA, Kiyota S, Riske KA, Dos Santos AA, Pinatto-Botelho MF, Bemquerer MP, Gueiros-Filho FJ, Chaimovich H, Schreier S, Cuccovia IM."	"Synthesis, biophysical and functional studies of two BP101 analogues modified by a hydrophobic chain and a cyclic peptide."
DRAMP20932	GILGKLWEGVKSIF	14	Hp1404	No entry found	Melittin	Not found	Heterometrus petersii	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	Alpha helix	"The peptide adopts an alpha-helical conformation in the membrane-mimicking environments and the presence of PE:PG and PC:CH liposomes, adopts a random coil conformation when mixed with PC:CH:SM liposomes. "	None	Function: Antibacterial activity against Gram-negative bacteria. 	"[Ref.29379033] Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 138 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 431 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 434 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 557 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 559 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 778 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 1034 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 1162 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 3290 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 3399 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 3543 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 3592 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 3904 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 4007 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 4319 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 4891 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 5018 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 671973 (MIC=3.13 ¦ÌM)"	"[Ref.29379033]Hemolysis 2% at 12.5 ¦ÌM against mouse red blood cell, hemolysis 11% at 25.0 ¦ÌM against mouse red blood cell, hemolysis 55% at 50.0 ¦ÌM against mouse red blood cell, hemolysis 92% at 100.0 ¦ÌM against mouse red blood cell, hemolysis 100% at 200.0 ¦ÌM against mouse red blood cell"	Linear	Free	Amidation	None	L	"[Ref.29379033] The cell survial  against HaCaT cells is 85%, 26%, 5% and 6% at peptide concentrations of 25, 50, 100 and 200 ¦ÌM"	Lipopolysaccharide (LPS)-binding	29379033	Sci Rep. 2018 Jan 29;8(1):1763. 	"Kim MK, Kang HK, Ko SJ, Hong MJ, Bang JK, Seo CH, Park Y."	Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa.
DRAMP20934	MNFNKFFVLFALIMVAVVGQSEAGWLKKLGKKIERVGQHTRDATIQTIGVAQQAVNVAATLKG	63	Lucilin Peptide	D7RT24	Cecropins	ATGAATTTTAATAAATTTTT	L. eximia maggots	"Antimicrobial, Antibacterial, Anti-Gram-, Wound-healing"	Transcript level	Alpha helix 	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria. Immunomodulatory activity. Decreasing the TNF-alpha production in PBMCs and inducing cellular migration in human keratinocytes.	"[Ref.29890152] Gram-negative bacteria: Escherichia coli DH10B (MIC=7.8 ¦Ìg/ml; MBC=7.8 ¦Ìg/ml), Escherichia coli ESBL (MIC=15.6 ¦Ìg/ml; MBC=15.6 ¦Ìg/ml), Enterobacter cloacae (MIC=125 ¦Ìg/ml; MBC=125 ¦Ìg/ml)"	"[Ref.29890152]Hemolysis 0% at 0.24 ¦Ìg/ml, hemolysis 0% at 0.49 ¦Ìg/ml, hemolysis 0% at 0.98 ¦Ìg/ml, hemolysis 0% at 1.95 ¦Ìg/ml, hemolysis 0% at 3.91 ¦Ìg/ml, hemolysis 0% at 7.81 ¦Ìg/ml, hemolysis 0% at 15.60 ¦Ìg/ml, hemolysis 0% at 31.00 ¦Ìg/ml, hemolysis 0% at 63.00 ¦Ìg/ml, hemolysis 0% at 125.00 ¦Ìg/ml, hemolysis 0% at 250.00 ¦Ìg/ml against human red blood cell"	Linear	Free	Free	None	L	[Ref.29890152] The peptide did not show cytotoxic activities against Vero cells. ##The peptide showed a toxic concentration from 62.5 ¦Ìg/ml with IC50 of 58.30 ¦Ìg/ml against PBMCs	Not found	29890152	Bioorg Med Chem Lett. 2012 Jun 15;22(12):4185-8.	"T¨¦llez GA, Zapata JA, Toro LJ, Henao DC, Bedoya JP, Rivera JD, Trujillo JV, Rivas-Santiago B, Hoyos RO, Castano JC."	"Identification, Characterization, Immunolocalization, and Biological Activity of Lucilin Peptide."
DRAMP20935	GFGMALKLLKKVL	13	"Macropin 1(solitary bee, insects, animals)"	C0HL98	Not found	Not found	Macropis fulvipes (Solitary bee) (Megilla fulvipes)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	"Alpha helix,random coil"	Not found	None	"[Ref.24616110] Antimicrobial peptide active against Gram-positive bacteria like B.subtilis, S.aureus and L.monocytogenes as well as against Gram-negative bacteria like E.coli and P.aeruginosa with minimum inhibitory concentrations (MIC) between 1.3 ?M and 35 ?M.Active against fungus C.albicans (MIC=6.3 ?M).Has little hemolytic activity . Adopts an alpha-helical structure in a membrane mimic environment. [Ref.29185466] Acts by disrupting membranes and bacterial cell wall structures.Binds to peptidoglycan and lipopolysaccharide (LPS)"	"[Ref.24616110] Gram-negative bacteria: Escherichia coli(MIC=3.0 ¦ÌM), Pseudomonas aeruginosa(MIC=35.0 ¦ÌM);## Gram-positive bacteria: Bacillus subtilis (MIC=1.3 ¦ÌM), Staphylococcus aureus(MIC=3.7 ¦ÌM);## Fungus: Candida albicans (MIC=6.3 ¦ÌM). ##[Ref.29185466]Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC=3.13 ¦ÌM), Staphylococcus aureus ATCC 29213 (MIC=3.13 ¦ÌM), Listeria monocytogenes KCTC 3710 (MIC=25 ¦ÌM);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa ATCC 15692 (MIC=6.25 ¦ÌM), Escherichia coli ATCC 25922 (MIC=6.25 ¦ÌM)"	"[Ref.24616110] LC50=160 ¦ÌM against human red blood cells. ##[Ref.29185466]5% hemolysis at 25 ¦ÌM against red blood cells, 93% hemolysis at 50 ¦ÌM against red blood cells"	Linear	Free	Amidation	None	L	"[Ref.29185466] In HaCaT cells, Macropin produced cell survival rates of 82% and 41% at  peptide concentrations of 25 and 50 ¦ÌM.## In Raw cells, Macropin produce cell survival rates of 41% and 0% at peptide concentrations of 25 and 50 ¦ÌM."	Not found	24616110##29185466	J Pept Sci. 2014 Jun;20(6):375-84. doi: 10.1002/psc.2625. Epub 2014 Mar 11.## Sci Rep. 2017 Nov 29;7(1):16580. doi: 10.1038/s41598-017-16784-6.	"Monincov¨¢ L, Veverka V, Slaninov¨¢ J, Bud¨§?¨ªnsk? M, Fu?¨ªk V, Bedn¨¢rov¨¢ L, Straka J, Ce?ovsk? V.## Ko SJ, Kim MK, Bang JK, Seo CH, Luchian T, Park Y."	"Structure-activity study of macropin, a novel antimicrobial peptide from the venom of solitary bee Macropis fulvipes (Hymenoptera: Melittidae).## Macropis fulvipes Venom component Macropin Exerts its Antibacterial and Anti-Biofilm Properties by Damaging the Plasma Membranes of Drug Resistant Bacteria."
DRAMP20936	RVKRFKKFFRKIKKGFRKIFKKTKIFIG	28	¦¤Pb-CATH1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.	"[Ref.28630199] Gram-positive bacteria: Staphylococcus aureus (ATCC 29213)(MIC>128 ¦Ìg/ml); B. cereus ATCC 10876 (MIC=46 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=3 ¦Ìg/ml), S. typhimurium ATCC 14028 (MIC=1.5 ¦Ìg/ml)"	"[Ref.28630199]1.4 ¡À 0.4% hemolysis at 8 ¦Ìg/ml, 5.1 ¡À 0.5%  hemolysis at 16 ¦Ìg/ml, 7.3 ¡À 0.6%  hemolysis at 32 ¦Ìg/ml, 12.2 ¡À 0.7% hemolysis at 64 ¦Ìg/ml against chicken red blood cells"	Linear	Free	Free	None	L	[Ref.28630199] No cytotoxicity information found	Not found	28630199	Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00530-17.	"Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C."	Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity
DRAMP20937	HRVKRNGFRKFMRRLKKFFAGG	22	Pb-CATH3	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.	"[Ref.28630199] Gram-positive bacteria: B. cereus ATCC 10876 (MIC=32 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦Ìg/ml), S. typhimurium ATCC 14028 (MIC=2 ¦Ìg/ml);##Clinical isolates: Escherichia coli (4.7 ¦Ìg/ml), K. pneumoniae (1.18 ¦Ìg/ml)"	"[Ref.28630199]0% hemolysis at 8 ¦Ìg/ml, 1.7 ¡À 0.5%  hemolysis at 16 ¦Ìg/ml, 3.1 ¡À 0.5%  hemolysis at 32 ¦Ìg/ml, 4.0 ¡À 0.2% hemolysis at 64 ¦Ìg/ml against chicken red blood cells"	Linear	Free	Free	None	L	[Ref.28630199] No cytotoxicity information found	Not found	28630199	Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00530-17.	"Kim D, Soundrarajan N, Lee J, Cho HS, Choi M, Cha SY, Ahn B, Jeon H, Le MT, Song H, Kim JH, Park C."	Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity
DRAMP20938	RLLRKFFRKLKKSV	14	Cbf-14	No entry found	Belongs to cathelicidin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix,beta-sheet,beta-turn,random coil"	"The percentages of possible occurring conformations involved helix, beta, turn and random are also quantified in various solutions "	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.	"[Ref.28522372]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=64 ¦Ìg/ml), Staphylococcus aureus (MIC=32 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=32 ¦Ìg/ml), Escherichia coli (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa (MIC=32 ¦Ìg/ml);##Yeasts: Candida albicans ATCC 10231 (MIC=64 ¦Ìg/ml), Candida albicans (MIC=64 ¦Ìg/ml)"	[Ref.28522372]2% hemolysis at 800 ¦Ìg/ml against mice red blood cells	Linear	Free	Free	None	L	"The percentages of possible occurring conformations involved helix, beta, turn and random are also quantified in various solutions "	Not found	28522372	Eur J Pharm Sci. 2017 Jul 15;105:169-177.	"Kang W, Liu H, Ma L, Wang M, Wei S, Sun P, Jiang M, Guo M, Zhou C, Dou J."	Effective antimicrobial activity of a peptide mutant Cbf-14-2 against penicillin-resistant bacteria based on its unnatural amino acids
DRAMP20939	RLLRKFFRKLKKSV	14	D-Cbf-14	No entry found	Belongs to cathelicidin	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic	"Alpha helix,beta-sheet,beta-turn,random coil"	"The percentages of possible occurring conformations involved helix, beta, turn and random are also quantified in various solutions "	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. All amino acids in the sequence are D-type.	"[Ref.28522372] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=64 ¦Ìg/ml), Staphylococcus aureus (MIC=32 ¦Ìg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=32 ¦Ìg/ml), Escherichia coli (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa (MIC=64 ¦Ìg/ml);##Yeasts: Candida albicans ATCC 10231 (MIC=64 ¦Ìg/ml), Candida albicans (MIC=64 ¦Ìg/ml)"	[Ref.28522372]1% hemolysis at 800 ¦Ìg/ml against mice red blood cells	Linear	Free	Free	None	D	"[Ref.28522372] In mice spleen cells, the peptide produced cell viability of 97% at 800 ¦Ìg/ml"	Not found	28522372	Eur J Pharm Sci. 2017 Jul 15;105:169-182.	"Kang W, Liu H, Ma L, Wang M, Wei S, Sun P, Jiang M, Guo M, Zhou C, Dou J."	Effective antimicrobial activity of a peptide mutant Cbf-14-3 against penicillin-resistant bacteria based on its unnatural amino acids
DRAMP20941	FVPWFSKFLKRIL	13	"[Pro3,DLeu9]TL(8) (Temporin L peptide derivative)"	No entry found	Derived from Temporin L	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	The analogues bearing a D residue showed a reduction in the percentage of helicity compared to the corresponding L analogues in the MMs 	None	"Function: Antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteria and Fungi. The position 9 of [Pro3,DLeu9]TL(8) is D-Leucine, L-Lysine replace L-Proline at the position 10 on the  peptide [Pro3,DLeu9]TL(2)."	"[Ref.28863356] Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3.125¦ÌM), Staphylococcus aureus Cowan I (MIC=6.25¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=3.125¦ÌM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=3.125¦ÌM), Escherichia coli D21 (MIC=12.5¦ÌM), Pseudomonas syringae pv tabaci 1918 (MIC=6.25¦ÌM), Pseudomonas aeruginosa ATCC 2785 (MIC=12.5¦ÌM);##Yeasts: Candida albicans ATCC 10231 (MIC=1.56¦ÌM), Candida crusei ATCC 6258 (MIC=1.56¦ÌM)"	"[Ref.28863356]49.30 ¡À 2.88% cytotoxic effect at 12.5 ¦ÌM, 66.86 ¡À 2.81%  cytotoxic effect at 25 ¦ÌM, 96.79 ¡À 1.24% cytotoxic effect at 50 ¦ÌM on HaCaT cells."	Linear	Free	Amidation	None	Mixed (D-Leu9)	"[Ref.28863356] The cytotoxic effect is 49.30¡À2.88%, 66.86¡À2.81% and 96.79¡À1.24% at peptide concentrations of 12.5, 25 and 50 ¦ÌM"	Not found	28863356	Eur J Med Chem. 2017 Oct 20;139:750-761.	"Merlino F, Carotenuto A, Casciaro B, MartorMerlino F, Carotenuto A, Casciaro B, Martora F, Loffredo MR, Di Grazia A, Yousif AM, Brancaccio D, Palomba L, Novellino E, Galdiero M, Iovene MR, Mangoni ML, Grieco P."	"Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities"
DRAMP20942	FVPWFSKFLKRIL	13	"[Pro3,DLeu9]TL(9) (Temporin L peptide derivative)"	No entry found	Derived from Temporin L	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	The analogues bearing a D residue showed a reduction in the percentage of helicity compared to the corresponding L analogues in the MMs 	None	"Function: Antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteria and Fungi. The position 9 of [Pro3,DLeu9]TL(9) is D-Leucine, D-Lysine replace L-Proline at the position 10 on the  peptide [Pro3,DLeu9]TL(2)."	"[Ref.28863356] Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3.125 ¦ÌM), Staphylococcus aureus Cowan I (MIC=12.5 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=3.125 ¦ÌM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=6.25 ¦ÌM), Escherichia coli D21 (MIC=12.5 ¦ÌM), Pseudomonas syringae pv tabaci 1918 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa ATCC 2785 (MIC=12.5 ¦ÌM);##Yeasts: Candida albicans ATCC 10231 (MIC=1.56 ¦ÌM), Candida crusei ATCC 6258 (MIC=1.56 ¦ÌM)"	"[Ref.28863356]7¡À4% hemolysis at 50 ¦ÌM, 5¡À3% hemolysis at 25 ¦ÌM, 5¡À2% hemolysis at 12.5 ¦ÌM, 1¡À2% hemolysis at 6.25 ¦ÌM, 0¡À1%  hemolysis at 3.125 ¦ÌM against human red blood cells. ##28.22 ¡À 3.52%  cytotoxic effect at 25 ¦ÌM, 87.9 ¡À 1.07% cytotoxic effect at 50 ¦ÌM on HaCaT cells."	Linear	Free	Amidation	None	"Mixed (D-Leu9, D-Lys10)"	"[Ref.28863356] The cytotoxic effect is 0%, 28.22¡À3.52% and 87.9¡À1.07% at 12.5, 25 and 50 ¦ÌM"	Not found	28863356	Eur J Med Chem. 2017 Oct 20;139:750-761.	"Merlino F, Carotenuto A, Casciaro B, Martora F, Loffredo MR, Di Grazia A, Yousif AM, Brancaccio D, Palomba L, Novellino E, Galdiero M, Iovene MR, Mangoni ML, Grieco P."	"Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities"
DRAMP20943	FVPWFSKFLWRIL	13	"[Pro3,DLeu9]TL(10) (Temporin L peptide derivative)"	No entry found	Derived from Temporin L	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	A distorted (type IV) 	None	"Function: Antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteria and Fungi. The position 9 of [Pro3,DLeu9]TL(8) is D-Leucine, L-Tryptophan replace L-Proline at the position 10 on the  peptide [Pro3,DLeu9]TL(2)."	"[Ref.28863356] Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=1.56 ¦ÌM), Staphylococcus aureus Cowan I (MIC=3.125 ¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=1.56 ¦ÌM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=3.125 ¦ÌM), Escherichia coli D21 (MIC=25 ¦ÌM), Pseudomonas syringae pv tabaci 1918 (MIC=1.56 ¦ÌM);##Yeasts: Candida albicans ATCC 10231 (MIC=3.125 ¦ÌM), Candida crusei ATCC 6258 (MIC=3.125 ¦ÌM)"	"[Ref.28863356]37¡À1% hemolysis at 50¦ÌM, 20¡À3% hemolysis at 25¦ÌM, 7¡À1% hemolysis at 12.5¦ÌM, 4¡À2% hemolysis at 6.25¦ÌM, 2¡À1%  hemolysis at 3.125¦ÌM against human red blood cells.##32.1 ¡À 2.21%  cytotoxic effect at 25¦ÌM, 89.3 ¡À 0.8% cytotoxic effect at 50 ¦ÌM on HaCaT cells."	Linear	Free	Amidation	None	Mixed (D-Leu9)	"[Ref.28863356] The cytotoxic effect is 0%, 32.1¡À2.21% and 89.3¡À0.8% at  12.5, 25 and 50 ¦ÌM"	Not found	28863356	Eur J Med Chem. 2017 Oct 20;139:750-761.	"Merlino F, Carotenuto A, Casciaro B, Martora F, Loffredo MR, Di Grazia A, Yousif AM, Brancaccio D, Palomba L, Novellino E, Galdiero M, Iovene MR, Mangoni ML, Grieco P."	"Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities"
DRAMP20944	FVPWFSKFLWRIL	13	"[Pro3,DLeu9]TL(11) (Temporin L peptide derivative)"	No entry found	Derived from Temporin L	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix	The analogues bearing a D residue showed a reduction in the percentage of helicity compared to the corresponding L analogues in the MMs 	None	"Function: Antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteria and Fungi. The position 9 of [Pro3,DLeu9]TL(10) is D-Leucine, D-Tryptophan replace L-Proline at the position 10 on the  peptide [Pro3,DLeu9]TL(2)."	"[Ref.28863356] Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3.125¦ÌM), Staphylococcus aureus Cowan I (MIC=3.125¦ÌM), Staphylococcus epidermidis ATCC 12228 (MIC=1.56¦ÌM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=3.125¦ÌM), Escherichia coli D21 (MIC=25¦ÌM), Pseudomonas syringae pv tabaci 1918 (MIC=3.125¦ÌM), Pseudomonas aeruginosa ATCC 2785 (MIC=50¦ÌM);##Yeasts: Candida albicans ATCC 10231 (MIC=3.125¦ÌM),Candida crusei ATCC 6258 (MIC=3.125¦ÌM)"	"[Ref.28863356]19.21 ¡À 1.44% cytotoxic effect at 12.5¦ÌM, 35.34 ¡À 5.99%  cytotoxic effect at 25¦ÌM, 96.77 ¡À 0.81% cytotoxic effect at 50 ¦ÌM on HaCaT cells."	Linear	Free	Amidation	None	"Mixed (D-Leu9, D-Trp10)"	"[Ref.28863356] The cytotoxic effect is 19.21¡À1.44%, 35.34¡À5.99% and 96.77¡À0.81% at 12.5, 25 and 50 ¦ÌM"	Not found	28863356	Eur J Med Chem. 2017 Oct 20;139:750-761.	"Merlino F, Carotenuto A, Casciaro B, Martora F, Loffredo MR, Di Grazia A, Yousif AM, Brancaccio D, Palomba L, Novellino E, Galdiero M, Iovene MR, Mangoni ML, Grieco P."	"Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities"
DRAMP20945	KWKLFKKIFKRIVQRIKDFLRN	22	Recombinant  Cecropin A (1¨C8)¨CLL37 (17¨C30) (C¨CL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria	"[Ref.29925795] Gram-negative bacteria: Escherichia coli CVCC 245 (MIC=7.2 ¡À 0.14 ¦Ìg/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2.2 ¡À 0.05 ¦Ìg/mL),L. mono. CVCC 1599 (MIC=2.1 ¡À 0.03 ¦Ìg/mL)"	[Ref.29925795] 50% hemolysis at 221 ¡À 3.45¦Ìg/ml against sheep red blood cells	Linear	Free	Free	None	L	[Ref.29925795] No cytotoxicity information found	Not found	29925795	Molecules. 2018 Jun 20;23(6). pii: E1491. 	"Wei X, Wu R, Zhang L, Ahmad B, Si D, Zhang R."	"Expression, Purification, and Characterization of a Novel Hybrid Peptide with Potent Antibacterial Activity"
DRAMP20955	LGDFFRKSKEKIGKEFKRIVQRIKDFLRNLAKRHHGYKRKFH	42	L31-P113	No entry found	Derived from LL-37	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix 	The peptide adopts a conformational structure with 80 % alpha helix.	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	[Ref.29859288] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=25?¡À?0 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16.6?¡À?7.2 ¦ÌM);##Fungi: Candida albicans ATCC 90028 (MIC=166.6?¡À?57.7 ¦Ìg/mL)	[Ref.29859288] Hemolysis 12.0?¡À?0.7% at 500 ¦Ìg/ml against human red blood cells	Linear	Free	Free	None	L	[Ref.29859288] No cytotoxicity information found	Not found	29859288	Gene. 2018 May 30. pii: S0378-1119(18)30617-6.	"Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S."	Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro.
DRAMP20956	ALGDFFRKSKEKIGKEFKRIVQRIKDFLRNLAKRHHGYKRKFHLEY	46	AL32-P113	No entry found	Derived from LL-37 and Hst-5	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic	Alpha helix 	The peptide adopts a conformational structure with 81 % alpha helix.	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity.	"[Ref.29859288] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=66.6?¡À?28.8 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=41.6?¡À?14.4 ¦ÌM), Extended-spectrum beta-lactamase producing Escherichia coli (MIC=41.6?¡À?14.4 ¦Ìg/mL), New Delhi metallo-bata-lactamase-1 producing Acinetobacter baumannii  (MIC=20.8?¡À?7.2 ¦Ìg/mL);##Fungi: Candida albicans ATCC 90028 (MIC=166.6?¡À?57.7 ¦Ìg/mL)"	[Ref.29859288] Hemolysis 10.4?¡À?2.2% at 500 ¦Ìg/ml against human red blood cells	Linear	Free	Free	None	L	[Ref.29859288] No cytotoxicity information found	Not found	29859288	Gene. 2018 May 30. pii: S0378-1119(18)30617-6.	"Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S."	Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro.
DRAMP20957	FFSLIPKLVKGLISAFK	17	StigA6	No entry found	Derived from scorpion venom peptide	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic, Antiproliferative"	Synthetic	Alpha helix 	"The peptide adopts helical conformation with some random structure at the N- and C-terminals. In sodium phosphate buffer (PBS) and water they have a predominantly random structure, but in 20 mM sodium dodecyl sulfate (SDS) and 2,2,2-trifluoroethanol (TFE) they have a typical alpha-helix structure."	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity against yeasts.Antiparasitic Activity against epimastigote forms of Trypanosoma cruzi. Antiproliferative Activity against HeLa cells.	"[Ref.29670004] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=2.34 ¦ÌM), Staphylococcus epidermidis ATCC 122225 (MIC=9.38 ¦ÌM), Enterococcus faecalis ATCC 4028 (MIC=1.17 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.69 ¦ÌM), Enterobacter cloacae ATCC 13047 (MIC=18.75 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=9.38 ¦ÌM);##yeasts: Candida albicans ATCC 90028 (MIC=9.38 ¦ÌM), Candida krusei ATCC 6258 (MIC=37.5 ¦ÌM), Candida glabrata ATCC 90030 (MIC=18.75 ¦ÌM);##StigA6 inhibit 100% of the epimastigote forms of Trypanosoma cruzi growth at 2.5 ?M;##HeLa cell line: IC50=14.01 ?M"	"[Ref.29670004] Hemolysis 0% at 1.17 ¦ÌM, hemolysis 2% at 2.34 ¦ÌM, hemolysis 15% at 4.69 ¦ÌM, hemolysis 27% at 9.38 ¦ÌM, hemolysis 30% at 18.75 ¦ÌM, hemolysis 30% at 37.50 ¦ÌM, hemolysis 27% at 75.00 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.29670004] The cell viability of HeLa cell lines is 19%, 15%, 11%, 29%, 9%, 13% and 8% at peptide concentrations of 2, 4, 8, 10, 15, 20 and 40 ¦ÌM.  ##The cell viability of 3T3 cell lines is 81%, 73%, 69%, 61%, 51%, 20% and 15% at peptide concentrati"	Not found	29670004	Toxins (Basel). 2018 Apr 18;10(4). pii: E161.	"Parente AMS, Daniele-Silva A, Furtado AA, Melo MA, Lacerda AF, Queiroz M, Moreno C, Santos E, Rocha HAO, Barbosa EG, Carvalho E, Silva-J¨²nior AA, Silva MS, Fernandes-Pedrosa MF."	"Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity."
DRAMP20958	FFKLIPKLVKGLISAFK	17	StigA16	No entry found	Derived from scorpion venom peptide	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic, Antiproliferative"	Synthetic	Alpha helix 	"The peptide adopts helical conformation with some random structure at the N- and C-terminals. In sodium phosphate buffer (PBS) and water they have a predominantly random structure, but in 20 mM sodium dodecyl sulfate (SDS) and 2,2,2-trifluoroethanol (TFE) they have a typical alpha-helix structure."	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity against yeasts.Antiparasitic Activity against epimastigote forms of Trypanosoma cruzi. Antiproliferative Activity against HeLa cells.	"[Ref.29670004] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=2.34 ¦ÌM), Staphylococcus epidermidis ATCC 122225 (MIC=9.38 ¦ÌM), Enterococcus faecalis ATCC 4028 (MIC=1.17 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2.34 ¦ÌM), Enterobacter cloacae ATCC 13047 (MIC=9.38 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=1.17 ¦ÌM);##yeasts: Candida albicans ATCC 90028 (MIC=4.69 ¦ÌM), Candida krusei ATCC 6258 (MIC=9.38 ¦ÌM), Candida glabrata ATCC 90030 (MIC=9.38 ¦ÌM);##StigA16 inhibit 100% of the epimastigote forms of Trypanosoma cruzi growth at 2.5 ?M;##HeLa cell line: IC50=13.01 ?M"	"[Ref.29670004] Hemolysis 0% at 1.17 [Ref.29670004] Hemolysis 0% at 1.17 ¦ÌM, hemolysis 2% at 2.34 ¦ÌM, hemolysis 10% at 4.69 ¦ÌM, hemolysis 20% at 9.38 ¦ÌM, hemolysis 35% at 18.75 ¦ÌM, hemolysis 37% at 37.50 ¦ÌM, hemolysis 40% at 75.00 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.29670004] The cell viability of HeLa cell lines is 15%, 21%, 16%, 9%, 8%, 10% and 11% at peptide concentrations of 2, 4, 8, 10, 15, 20 and 40 ¦ÌM. ##The cell viability of 3T3 cell lines is 69%, 77%, 62%, 47%, 21%, 15% and 15% at peptide concentratio"	Not found	29670004	Toxins (Basel). 2018 Apr 18;10(4). pii: E161.	"Parente AMS, Daniele-Silva A, Furtado AA, Melo MA, Lacerda AF, Queiroz M, Moreno C, Santos E, Rocha HAO, Barbosa EG, Carvalho E, Silva-J¨²nior AA, Silva MS, Fernandes-Pedrosa MF."	"Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity."
DRAMP20959	ILKKLLKGVKSI	12	Hp1404-T1c	No entry found	Derived from Hp1404	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix	The peptide adopts an alpha-helical conformation in the membrane-mimicking environments and adopts a random coil conformation in the presence of all liposome types .	None	Function: Antibacterial activity against Gram-negative bacteria. 	"[Ref.29379033] Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 138 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 431 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 434 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 557 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 559 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 778 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 1034 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 1162 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 3399 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 3592 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 3904 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 4007 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 4319 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 4891 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 5018 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 671973 (MIC=6.25 ¦ÌM)"	"[Ref.29379033] Hp1404-T1c does not induce substantial hemolysis, even at the high tested concentration (200?¦ÌM) against mouse red blood cells"	Linear	Free	Amidation	None	L	"[Ref.29379033] The cell survial  against HaCaT cells is 100%, 70%, 66% and 53% at peptide concentrations of 25, 50, 100 and 200 ¦ÌM"	Lipopolysaccharide (LPS)-binding and entering bacterial cells and interact with their DNA	29379033	Sci Rep. 2018 Jan 29;8(1):1763. 	"Kim MK, Kang HK, Ko SJ, Hong MJ, Bang JK, Seo CH, Park Y."	Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa.
DRAMP20960	ILKKLLKKVKSI	12	Hp1404-T1d	No entry found	Derived from Hp1404	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix	The peptide adopts an alpha-helical conformation in the membrane-mimicking environments and adopts a random coil conformation in the presence of all liposome types .	None	Function: Antibacterial activity against Gram-negative bacteria. 	"[Ref.29379033] Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 138 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 431 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 434 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 557 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 559 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 778 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 1034 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 1162 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 3290 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 3399 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 3543 (MIC=25 ¦ÌM), Pseudomonas aeruginosa 3592 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 3904 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 4007 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 4319 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 4891 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 5018 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 671973 (MIC=1.56 ¦ÌM)"	"[Ref.29379033] Hp1404-T1d does not induce substantial hemolysis, even at the high tested concentration (200?¦ÌM) against mouse red blood cells"	Linear	Free	Amidation	None	L	"[Ref.29379033] The cell survial  against HaCaT cells is 58%, 48%, 52% and 34% at peptide concentrations of 25, 50, 100 and 200 ¦ÌM"	Lipopolysaccharide (LPS)-binding	29379033	Sci Rep. 2018 Jan 29;8(1):1763. 	"Kim MK, Kang HK, Ko SJ, Hong MJ, Bang JK, Seo CH, Park Y."	Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa.
DRAMP20961	ILKKLLKKVKKI	12	Hp1404-T1e	No entry found	Derived from Hp1404	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic	Alpha helix	The peptide adopts an alpha-helical conformation in the membrane-mimicking environments and adopts a random coil conformation in the presence of all liposome types .	None	Function: Antibacterial activity against Gram-negative bacteria. 	"[Ref.29379033] Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 138 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 431 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 434 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 557 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 559 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 778 (MIC= 1.56 ¦ÌM), Pseudomonas aeruginosa 1034 (MIC= 1.56 ¦ÌM), Pseudomonas aeruginosa 1162 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 3290 (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa 3399 (MIC=0.78 ¦ÌM), Pseudomonas aeruginosa 3543 (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa 3592 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 3904 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 4007 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 4319 (MIC=3.13 ¦ÌM), Pseudomonas aeruginosa 4891 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 5018 (MIC=1.56 ¦ÌM), Pseudomonas aeruginosa 671973 (MIC=1.56 ¦ÌM)"	"[Ref.29379033] Hp1404-T1e does not induce substantial hemolysis, even at the high tested concentration (200?¦ÌM) against mouse red blood cells"	Linear	Free	Amidation	None	L	"[Ref.29379033] The cell survial  against HaCaT cells is 100%, 100%, 100%, 99% at peptide concentrations of 25, 50, 100 and 200 ¦ÌM"	Lipopolysaccharide (LPS)-binding and entering bacterial cells and interact with their DNA	29379033	Sci Rep. 2018 Jan 29;8(1):1763. 	"Kim MK, Kang HK, Ko SJ, Hong MJ, Bang JK, Seo CH, Park Y."	Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa.
DRAMP20963	LRLKKYKVPQL	11	Cp1 alpha s1-casein peptide derivative	No entry found	Derived from bovine alpha S1-casein	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, low hemolytic and toxic effects"	Synthetic	Unordered conformation	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.29783753] Gram-negative bacteria: Escherichia coli (ATCC 25922)(MIC=64¦ÌM);Escherichia coli (UB1005)(MIC=128¦ÌM);Salmonella pullorum (C7913)(MIC=256¦ÌM);Salmonella enterica subsp enterica (CMCC 50071)(MIC=256¦ÌM);##Gram-positive bacteria: Staphylococcus aureus (ATCC 29213)(MIC=640¦ÌM);L. monocytogenes (CMCC 54004)(MIC=64¦ÌM)	[Ref.2978375]Hemolysis 0% at 16¦ÌM;Hemolysis 23.54% at 512¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.29783753] In 293 cells, The peptide had no cytotoxic activity at concentrations of 1-512 ¦ÌM. The cell survival rates are 100%, 96%, 98%, 105%, 104%, 112%, 116%, 114% and 103% at concentrations of 1, 2, 4, 8, 16, 32, 64, 128, 256, 512 ¦ÌM"	Not found	29783753	Molecules. 2018 May 19;23(5). pii: E1220.	"Hou J, Liu Z, Cao S, Wang H, Jiang C, Hussain MA, Pang S"	Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine 
DRAMP20964	KWKLFKKIFKRIVQRIKDFLRN	22	Synthesized Cecropin A (1¨C8)¨CLL37 (17¨C30) (C¨CL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. 	[Ref.29920061] Gram-negative bacteria: Escherichia coli (CVCC 245)(MIC=7.0 ¡À 0.21¦Ìg/mL);##Gram-positive bacteria: Staphylococcus aureus (ATCC 25923)(MIC=2.0 ¡À 0.02¦Ìg/mL );L. mono. (CVCC 1599)(MIC=2.2 ¡À 0.05¦Ìg/mL)	[Ref.29920061]HC50 =219 ¡À 2.98¦Ìg/mL against sheep erythrocyte cells	Linear	Free	Free	None	L	[Ref.29925795] No cytotoxicity information found	Not found	29920061	Molecules. 2018 Jun 20;23(6). pii: E1491.	"Wei X, Wu R, Zhang L, Ahmad B, Si D, Zhang R."	"Expression, Purification, and Characterization of a Novel Hybrid Peptide with Potent Antibacterial Activity."
DRAMP20965	MNKVKEWIKYLKSLFSM	17	"LPcin-YK3 (bovine cathelicidin, cattle, ruminant, mammals, animals)"	No entry found	Not found	Not found	Bovine Lactophoricin	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	"Random coil, alpha helix"	LPcin-YK3 peptide is a random coil in aqueous solution and forms an 	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	"[Ref.30021422] Gram-positive bacteria : Streptococcus mutans KCCM 40105 (MIC=1.25 ¦Ìg/ml), Propionibacteria acnes KCCM 41747 (MIC=1.25 ¦Ìg/ml), Staphylococcus aureus KCTC 1621 (MIC=0.62 ¦Ìg/ml);##Gram-negative bacteria : Porphyromonas gingvalis KCTC 5352 (MIC=0.62 ¦Ìg/ml), Escherichia coli KCCM 41290 (MIC=1.25 ¦Ìg/ml);##Fungi : Candida albicans KCTC 17712 (MIC=10.0 ¦Ìg/ml)"	[Ref.30021422] 0% hemolysis  at 40 ¦Ìg/ml against mouse red blood cell	Linear	Free	Free	None	L	[Ref.30021422] No cytotoxicity information found	Not found	30021422	J Microbiol Biotechnol.?2018 Aug 28;28(8):1299-1309. doi: 10.4014/jmb.1805.05001.	"Ji-Sun Kim,Ji-Ho Jeong, Jang-Hee Cho,Dong-Hee Lee and Yongae Kim"	Antimicrobial Activity of Antimicrobial Peptide LPcin-YK3 Derived from Bovine Lactophoricin
DRAMP20966	GLTRLFSVIK	10	"andricin B (Andrias davidianus, Amphibians, Animals)"	No entry found	Not found	Not found	Andrias davidianus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Random coil	"The residues Lys and Arg possess the positive charge, and charge-induced folding may influence the structure."	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Saccharomyces cerevisiae, Aspergillus niger"	"[Ref.29130500]Gram-positive bacteria : Bacillus subtilis CICC 10034 (MIC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml;MBC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml), Staphylococcus aureus CICC10306 (MIC=16 ¦Ìg/ml, 16.7 ¦ÌMol/ml;MBC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml), Staphylococcus aureus CICC 10384 (MIC=16 ¦Ìg/ml, 16.7 ¦ÌMol/ml;MBC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml), Listeria innocua CICC 10417 (MIC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml;MBC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml);##Gram-negative bacteria : Escherichia coli CICC10293 (MIC=16 ¦Ìg/ml, 16.7 ¦ÌMol/ml;MBC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml), Pseudomonas aeruginosa CICC 21636 (MIC=8 ¦Ìg/ml, 8.3 ¦ÌMol/ml;MBC=16 ¦Ìg/ml, 16.7 ¦ÌMol/ml), Serratia marcescens ATCC 4112 (MIC=8 ¦Ìg/ml, 8.3 ¦ÌMol/ml;MBC=16 ¦Ìg/ml, 16.7 ¦ÌMol/ml), Enterobacter cloacae CICC 21539 (MIC=16 ¦Ìg/ml, 16.7 ¦ÌMol/ml;MBC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml), Salmonella paratyphi CICC 10437 (MIC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml;MBC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml);##Fungi : Aspergillus niger CICC 2124 (MIC=64 ¦Ìg/ml, 66.8 ¦ÌMol/ml;MBC=64 ¦Ìg/ml, 66.8 ¦ÌMol/ml), Candida albicans CICC 1965 (MIC=32 ¦Ìg/ml, 33.4 ¦ÌMol/ml;MBC=64 ¦Ìg/ml, 66.8 ¦ÌMol/ml), Saccharomyces cerevisiae CICC 1002 (MIC=64 ¦Ìg/ml, 66.8 ¦ÌMol/ml;MBC=64 ¦Ìg/ml, 66.8 ¦ÌMol/ml)"	"[Ref.29130500] 0% hemolysis  at 64 ¦Ìg/ml , 0.5% hemolysis at 128 ¦Ìg/ml , 2% hemolysis  at 256 ¦Ìg/ml , 13% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	[Ref.29130500] No cytotoxicity information found	Not found	29130500	Lett Appl Microbiol.?2018 Jan;66(1):38-43. doi: 10.1111/lam.12823.	"J. Pei, Z. Feng,T. Ren,H. Sun,H. Han,W. Jin,J. Dang and Y. Tao"	"Purifification, characterization and application of a novel antimicrobial peptide from Andrias davidianus blood"
DRAMP20967	AIGHCLGATL	10	"andricin 01 (Andrias davidianus, Amphibians, Animals)"	No entry found	Not found	Not found	Andrias davidianus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28461043] Gram-positive bacteria : Bacillus subtilis CICC 10034 (MIC=32 ¦Ìg/ml;MBC=32 ¦Ìg/ml), Bacillus megaterium CICC 10448 (MIC=8 ¦Ìg/ml;MBC=16 ¦Ìg/ml), Staphylococcus aureus CICC 10306 (MIC=32 ¦Ìg/ml;MBC=32 ¦Ìg/ml), Staphylococcus aureus CICC 10384 (MIC=32 ¦Ìg/ml;MBC=32 ¦Ìg/ml), Listeria innocua CICC 10417 (MIC=32 ¦Ìg/ml;MBC=32 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli CICC 10293 (MIC=8 ¦Ìg/ml;MBC=16 ¦Ìg/ml), Escherichia coli CGMCC 3373 (MIC=8 ¦Ìg/ml;MBC=16 ¦Ìg/ml), Escherichia coli CICC 10302 (MIC=8 ¦Ìg/ml;MBC=16 ¦Ìg/ml), Escherichia coli CICC 10300 (MIC=8 ¦Ìg/ml;MBC=16 ¦Ìg/ml), Pseudomonas aeruginosa CICC 21636 (MIC=4 ¦Ìg/ml;MBC=8 ¦Ìg/ml), Alcaligenes faecalis ATCC 8750 (MIC=8 ¦Ìg/ml;MBC=16 ¦Ìg/ml), Serratia marcescens ATCC 4112 (MIC=8 ¦Ìg/ml;MBC=8 ¦Ìg/ml), Enterobacter cloacae CICC 21539 (MIC=4 ¦Ìg/ml;MBC=8 ¦Ìg/ml), Salmonella Paratyphi CICC 10437 (MIC=8 ¦Ìg/ml;MBC=16 ¦Ìg/ml)"	"[Ref.28461043] 0% hemolysis at 25 ¦Ìg/ml , 0% hemolysis at 50 ¦Ìg/ml , 4.3 ¡À 0.16% hemolysis at 100 ¦Ìg/ml , 16.3 ¡À 2.16% hemolysis at 200 ¦Ìg/ml against human hepatocyte cell line and human renal epithelial cells;0% hemolysis at 0¨C50 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.28461043] The cell viability of HL-7702 cells is 100.0¡À0.30%, 100.5¡À0.52%, 86.8¡À2.10% and 52.1¡À1.81% at peptide concentrations of 25, 50, 100 and 200 ¦Ìg/ml. ##The cell viability of HREpiC cells is 100.1¡À0.20%, 103.1¡À1.20%, 82.3¡À1.84% and 50.3¡À2.05%"	Not found	28461043	Int J Antimicrob Agents.?2017 Jul;50(1):41-46. doi: 10.1016/j.ijantimicag.2017.02.013.	"Jinjin Pei, Lei Jiang"	Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique
DRAMP20968	MMRVMRRKTKVIWEKKDFIGLYSID	25	"Catesbeianin-1 (Ranidae, Anura, Amphibia, Animals)"	C5IAX4	Not found	Not found	Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	Alpha helix	"Catesbeianin-1 is an amphi pathic a-helix and that the helical wheel is divided into two parts, namely, a hydrophobic face and a hydro philic face."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28258530] Gram-positive bacteria : Staphylococcus aureus ATCC 25923 (MIC=3.1 ¦Ìg/ml;MBC=6.3 ¦Ìg/ml), B. subtilis ATCC6633 (MIC=25 ¦Ìg/ml;MBC=50 ¦Ìg/ml), Streptococcus suis CVCC606 (MIC=3.1 ¦Ìg/ml;MBC=12.5 ¦Ìg/ml), Listeria monocytogenes ATCC19115 (MIC=12.5 ¦Ìg/ml;MBC=25 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=3.1 ¦Ìg/ml;MBC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC227853 (MIC=12.5 ¦Ìg/ml;MBC=25 ¦Ìg/ml), Salmonella spp. CVCC 3377 (MIC=6.3 ¦Ìg/ml;MBC=25 ¦Ìg/ml), Klebsiella pneumoniae H507 (MIC=25 ¦Ìg/ml;MBC=100 ¦Ìg/ml)"	"[Ref.28258530] 0% hemolysis at 0 ¦Ìg/ml , hemolysis 3% at 25 ¦Ìg/ml , 7% hemolysis at 50 ¦Ìg/ml , 8% hemolysis at 100 ¦Ìg/ml , 35% hemolysis at 200 ¦Ìg/ml , 50% hemolysis at 300 ¦Ìg/ml , 85% hemolysis at 400 ¦Ìg/ml , 95% hemolysis at 500 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.28258530] The cell viability of HEK293T cells is 102%, 103%, 103%, 100%, 98% and 85% at peptide concentrations of 0, 20, 40, 60, 80 and 100 ¦Ìg/ml. ##The cell viability of HL-7200 cells is 107%, 106%, 99%, 95% and 88% at peptide concentrations of 0,"	Not found	28258530	Biotechnol Lett. 2017 Jun;39(6):897-903. doi: 10.1007/s10529-017-2312-7.	Huihui Xu . Yang Zhang . Xin Feng . Kunyuan Tie . Yuan Cao . Wenyu Han	"Catesbeianin-1, a novel antimicrobial peptide isolatedfrom the skin of Lithobates catesbeianus (American bullfrog)"
DRAMP20969	KLLKHKLLVTLA	12	"HJH-1 (bovine cathelicidin, cattle, ruminant, mammals, animals)"	No entry found	Not found	Not found	Bovine	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	"[Ref.30110916]Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=25 ¦Ìg/ml), Clinical Staphylococcus aureus (MIC=25 ¦Ìg/ml), ;##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=12.5 ¦Ìg/ml), Clinical Escherichia coli (MIC=25 ¦Ìg/ml), Salmonella pullorum CVCC3533 (MIC=6.25 ¦Ìg/ml), Clinical Salmonella (MIC=6.25 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90029 (MIC=50 ¦Ìg/ml)"	"[Ref.30110916] 8% hemolysis at 50 ¦Ìg/ml , 12% hemolysis at 100 ¦Ìg/ml , 16% hemolysis at 200 ¦Ìg/ml , 17% hemolysis at 300 ¦Ìg/ml , 18% hemolysis at 400 ¦Ìg/ml against rabbit red blood cells"	Linear	Free	Free	None	L	[Ref.30110916] No cytotoxicity information found	Not found	30110916	Molecules. 2018 Aug 14;23(8). pii: E2026. doi: 10.3390/molecules23082026.	"Qing Wang, Yanzhao Xu, Mengmeng Dong, Bolin Hang, Yawei Sun, Lei Wang,Yongqiang Wang, Jianhe Hu, and Wenju Zhang "	"HJH-1, a Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity Antimicrobial Peptide"
DRAMP20970	VNFKLLSHSLLVTLASHL	18	"P3 (bovine cathelicidin, cattle, ruminant, mammals, animals)"	P01966	Belongs to the globin family.	HBA	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	"[Ref.25753638] Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=25 ¦Ìg/ml), Clinical Staphylococcus aureus (MIC=12.5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=12.5 ¦Ìg/ml), Clinical Escherichia coli (MIC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa clinical strain (MIC=25 ¦Ìg/ml);##Fungi : Candida albicans Clinical strain (MIC=25 ¦Ìg/ml), Candida albicans ATCC 90029 (MIC=50 ¦Ìg/ml)"	"[Ref.25753638] 3% hemolysis at 50 ¦Ìg/ml , 5% hemolysis  at 100 ¦Ìg/ml , 7% hemolysis at 200 ¦Ìg/ml , 7.5% hemolysis at 300 ¦Ìg/ml , 8% hemolysis at 400 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.25753638] The cell viability of HaCaT cell lines is 93% and 94% at peptide concentrations of 200 and 400 ¦Ìg/ml. In kumning mice, the LD50 of P3 is 160 mg/kg for i.p. injection, while the LD50 of PMB(served as a control) is 50 mg/kg. No mortality w"	Not found	25753638	Antimicrob Agents Chemother. 2015 May;59(5):2835-41. doi: 10.1128/AAC.04932-14.	"Qinghua Zhang, Yanzhao Xu, Qing Wang, Bolin Hang, Yawei Sun, Xiaoxiao Wei, Jianhe Hu"	Potential of Novel Antimicrobial Peptide P3 from Bovine Erythrocytes and Its Analogs To Disrupt Bacterial Membranes In Vitro and Display Activity against Drug-Resistant Bacteria in a Mouse Model
DRAMP20971	KLLSHSLLVTLA	12	JH-0 (Derived from  P3)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25753638]Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=6.25 ¦Ìg/ml), Clinical Staphylococcus aureus (MIC=6.25 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=6.25 ¦Ìg/ml), Clinical Escherichia coli (MIC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa clinical strain (MIC=6.25 ¦Ìg/ml)"	"[Ref.25753638] 2.5% hemolysis at 50 ¦Ìg/ml , 4% hemolysis at 100 ¦Ìg/ml , 5% hemolysis at 200 ¦Ìg/ml , 6% hemolysis at 300 ¦Ìg/ml , 7% hemolysis at 400 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.25753638] The cell viability of HaCaT cell lines is 88% and 85% at peptide concentrations of 200 and 400 ¦Ìg/ml. In Kunming mice,  the LD50 of JH-0 is 120 mg/kg for i.p. injection, while the LD50 of PMB(served as a control) is 50 mg/kg. No mortalit"	Not found	25753638	Antimicrob Agents Chemother. 2015 May;59(5):2835-41. doi: 10.1128/AAC.04932-14.	"Qinghua Zhang, Yanzhao Xu, Qing Wang, Bolin Hang, Yawei Sun, Xiaoxiao Wei, Jianhe Hu"	Potential of Novel Antimicrobial Peptide P3 from Bovine Erythrocytes and Its Analogs To Disrupt Bacterial Membranes In Vitro and Display Activity against Drug-Resistant Bacteria in a Mouse Model
DRAMP20972	KLLRHRLLVTLA	12	JH-1 (Derived from  P3)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25753638] Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=6.25 ¦Ìg/ml), Clinical Staphylococcus aureus (MIC=6.25 ¦Ìg/ml), ;##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=3.125 ¦Ìg/ml), Clinical Escherichia coli (MIC=6.25 ¦Ìg/ml), Pseudomonas aeruginosa clinical strain (MIC=12.5 ¦Ìg/ml)"	"[Ref.25753638] 2% hemolysis at 50 ¦Ìg/ml , 2.5% hemolysis at 100 ¦Ìg/ml , 2.5% hemolysis at 200 ¦Ìg/ml , 3% hemolysis at 300 ¦Ìg/ml , 4% hemolysis at 400 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.25753638] The cell viability of HaCaT cell lines is 84% and 80% at peptide concentrations of 200 and 400 ¦Ìg/ml. In Kunming mice, the LD50 of JH-1 is 94 mg/kg for i.p. injection, while the LD50 of PMB(served as a control) is 50 mg/kg. No mortality "	Not found	25753638	Antimicrob Agents Chemother. 2015 May;59(5):2835-41. doi: 10.1128/AAC.04932-14.	"Qinghua Zhang, Yanzhao Xu, Qing Wang, Bolin Hang, Yawei Sun, Xiaoxiao Wei, Jianhe Hu"	Potential of Novel Antimicrobial Peptide P3 from Bovine Erythrocytes and Its Analogs To Disrupt Bacterial Membranes In Vitro and Display Activity against Drug-Resistant Bacteria in a Mouse Model
DRAMP20973	VRFKLLSHSLLVTLASHL	18	JH-2 (Derived from  P3)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	"[Ref.25753638] Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=12.5 ¦Ìg/ml), Clinical Staphylococcus aureus (MIC=6.25 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=6.25 ¦Ìg/ml), Clinical Escherichia coli (MIC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa clinical strain (MIC=6.25 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90029 (MIC=25 ¦Ìg/ml), Candida albicans Clinical strain (MIC=25 ¦Ìg/ml)"	"[Ref.25753638] 2% hemolysis at 50 [Ref.25753638] 2% hemolysis at 50 ¦Ìg/ml , 2.5% hemolysis at 100 ¦Ìg/ml , 3.5% hemolysis at 200 ¦Ìg/ml , 4% hemolysis at 300 ¦Ìg/ml , 4% hemolysis at 400 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.25753638] The cell viability of HaCaT cell lines is 88% and 84% at peptide concentrations of 200 and 400 ¦Ìg/ml. In Kunming mice, the LD50 of JH-2 is 133 mg/kg for i.p. injection, while the LD50 of PMB(served as a control) is 50 mg/kg. no mortality"	Not found	25753638	Antimicrob Agents Chemother. 2015 May;59(5):2835-41. doi: 10.1128/AAC.04932-14.	"Qinghua Zhang, Yanzhao Xu, Qing Wang, Bolin Hang, Yawei Sun, Xiaoxiao Wei, Jianhe Hu"	Potential of Novel Antimicrobial Peptide P3 from Bovine Erythrocytes and Its Analogs To Disrupt Bacterial Membranes In Vitro and Display Activity against Drug-Resistant Bacteria in a Mouse Model
DRAMP20974	RRFKLLSHSLLVTLASHL	18	JH-3 (Derived from  P3)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	"[Ref.25753638]Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=6.25 ¦Ìg/ml), Clinical Staphylococcus aureus (MIC=3.125 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=3.125 ¦Ìg/ml), Clinical Escherichia coli (MIC=3.125 ¦Ìg/ml), Pseudomonas aeruginosa clinical strain (MIC=6.25 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90029 (MIC=12.5 ¦Ìg/ml), Candida albicans Clinical strain (MIC=6.25 ¦Ìg/ml)"	"[Ref.25753638] 8% hemolysis at 50 ¦Ìg/ml , 13% hemolysis at 100 ¦Ìg/ml , 17% hemolysis at 200 ¦Ìg/ml , 18% hemolysis at 300 ¦Ìg/ml , 18.5% hemolysis at 400 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.25753638] The cell viability of HaCaT cell lines is 86% and 86% at peptide concentrations of 200 and 400 ¦Ìg/ml. In Kunming mice, the LD50 of JH-3 is 180 mg/kg for i.p. injection, , while the LD50 of PMB(served as a control) is 50 mg/kg. No mortali"	Not found	25753638	Antimicrob Agents Chemother. 2015 May;59(5):2835-41. doi: 10.1128/AAC.04932-14.	"Qinghua Zhang, Yanzhao Xu, Qing Wang, Bolin Hang, Yawei Sun, Xiaoxiao Wei, Jianhe Hu"	Potential of Novel Antimicrobial Peptide P3 from Bovine Erythrocytes and Its Analogs To Disrupt Bacterial Membranes In Vitro and Display Activity against Drug-Resistant Bacteria in a Mouse Model
DRAMP20975	KFFKKLKKAVKKGFKKFAKV	20	OH-CM6 (Derived from  OH-CATH30)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	"[Ref.22491685] Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=12.5 ¦Ìg/ml), Staphylococcuss aureus ATCC 43300 MRSA (MIC=3.125 ¦Ìg/ml), Staphylococcuss aureus clinical strain 1 (MIC=6.25 ¦Ìg/ml), Staphylococcuss aureus clinical strain 2 (MIC=3.125 ¦Ìg/ml), Staphylococcuss aureus clinical strain 3 (MIC=12.5 ¦Ìg/ml), Enterococcus faecalis ATCC 29212 (MIC=25 ¦Ìg/ml) ;##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=12.5 ¦Ìg/ml), Escherichia coli ML-35p (MIC=6.25 ¦Ìg/ml), Escherichia coli clinical strain 1 (MIC=12.5 ¦Ìg/ml), Escherichia coli clinical strain 2 (MIC=3.125 ¦Ìg/ml), Escherichia coli clinical strain 3 (MIC=1.56 ¦Ìg/ml), Escherichia coli clinical strain 4 (MIC=12.5 ¦Ìg/ml), Escherichia coli clinical strain 5 (MIC=6.25 ¦Ìg/ml), Escherichia coli clinical strain 6 (MIC=3.125 ¦Ìg/ml), Enterobacter cloacae ATCC 13047 (MIC>100 ¦Ìg/ml), Enterobacter cloacae clinical strain (MIC>100 ¦Ìg/ml), Enterobacter aerogenes clinical strain (MIC>100 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa PA 01 (MIC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa clinical strain 1 (MIC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa clinical strain 2 (MIC=6.25 ¦Ìg/ml), Haemophilus influenzae ATCC 49247 (MIC=3.125 ¦Ìg/ml), Haemophilus influenzae ATCC 49766 (MIC=6.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=6.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=3.125 ¦Ìg/ml) ;##Fungi : Candida albicans ATCC 2002 (MIC>200 ¦Ìg/ml), Candida albicans clinical strain (MIC>200 ¦Ìg/ml)"	"[Ref.22491685] 13% hemolysis at 100 ¦Ìg/ml , 17% hemolysis at 200 ¦Ìg/ml , 18% hemolysis at 300 ¦Ìg/ml , 18.5% hemolysis at 400 ¦Ìg/ml against human red blood cells"	Linear	Free	Free	None	L	"[Ref.22491685] The cell viability of HaCaT cell lines is 76%, 62% and 53% at peptide concentrations of 50, 100, 200 ¦Ìg/ml. In Kunming mice, the LD50 of OH-CATH30 is 120 mg/kg for i.p. injection, while those of pexiganan(control 1) and PMB(control 2) are"	Not found	22491685	Antimicrob Agents Chemother. 2012 Jun;56(6):3309-17. doi: 10.1128/AAC.06304-11.	"Sheng-An Li, Wen-Hui Lee, and Yun Zhang"	Efficacy of OH-CATH30 and Its Analogs against Drug-ResistantBacteria In Vitro and in Mouse Models
DRAMP20976	RKYVRFLHRWVKYFRAYL	18	"adevonin (Derived from Adenanthera pavonina trypsin inhibitor (ApTI))
inhibitor (ApTI))"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	"Adevonin showed that its secondary structure varies according to the environment, acquiring "	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.30570384]Gram-positive bacteria : Staphylococcus aureus ATCC 80958 (MIC=7.35 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 35218 (MIC=7.35 ¦ÌM), Klebsiella oxytoca ATCC 13182 (MIC=1.84 ¦ÌM), Klebsiella pneumoniae ATCC 70603 (MIC=3.67 ¦ÌM), Serratia marcesens ATCC 13880 (MIC=1.84 ¦ÌM), Klebsiella pneumoniae KpC+ 001825971 (MIC=25.6 ¦ÌM)"	"[Ref.30570384] 0% hemolysis at 43.75 ¦ÌM , 72.5% hemolysis at 175 ¦ÌM , 77% hemolysis at 350 ¦Ìg/ml against human type O erythrocytes"	Linear	Free	Free	None	L	"[Ref.30570384] In fibroblasts, a significant reduction of cell viability, of 25% on average, is observed in each time interval(24,48 and 72h) in the highest peptide concentration(10 ¦ÌM)"	Not found	30570384	Pathog Glob Health.?2018 Dec;112(8):438-447. doi: 10.1080/20477724.2018.1559489.	"Mayara S. Rodrigues, Caio F. R. de Oliveira, Lu¨ªs H. O. Almeida, Simone M.Neto, Ana Paula A. Boleti, Edson L. dos Santos, Marlon H. Cardoso, Suzana,M. Ribeiro, Oct¨¢vio L. Franco, Fernando S. Rodrigues, Alexandre J. Macedo,Fl¨¢via R. Brust & Maria L¨ªgia R. Macedo"	"Adevonin, a novel synthetic antimicrobial peptide designed from the Adenanthera pavonina trypsin inhibitor (ApTI) sequence"
DRAMP20977	WLLKRWKKLL	10	Anoplin-1 (Derived from  Anoplin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25316570]Gram-positive bacteria : Staphylococcus aureus (MIC=32 ¦Ìg/ml), bacillus subtilis (MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli (MIC=64 ¦Ìg/ml), Peudomonas eruginosa (MIC=8 ¦Ìg/ml)"	"[Ref.25316570] 0% hemolysis at 100 ¦Ìg/ml , 1% hemolysis at 200 ¦Ìg/ml against mice red blood cells"	Linear	Free	Amidation	None	L	[Ref.25316570] No cytotoxicity information found	Not found	25316570	J Pept Sci. 2014 Dec;20(12):945-51. doi: 10.1002/psc.2705.	"Yang Wang, Jianbo Chen, Xin Zheng, Xiaoli Yang, Panpan Ma,Ying Cai,Bangzhi Zhangb,and Yuan Chen"	Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity
DRAMP20978	wllkrwkkll	10	Anoplin-2 (Derived from  Anoplin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25316570]Gram-positive bacteria : Staphylococcus aureus (MIC=16 ¦Ìg/ml), bacillus subtilis (MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli (MIC=16 ¦Ìg/ml), Peudomonas eruginosa (MIC=8 ¦Ìg/ml)"	"[Ref.25316570] 0% hemolysis at 25 ¦Ìg/ml , 1% hemolysis at 50 ¦Ìg/ml , 0% hemolysis at 100 ¦Ìg/ml , 0.5% hemolysis at 200 ¦Ìg/ml against mice red blood cells"	Linear	Free	Amidation	None	D	[Ref.25316570] No cytotoxicity information found	Not found	25316570	J Pept Sci. 2014 Dec;20(12):945-51. doi: 10.1002/psc.2705.	"Yang Wang, Jianbo Chen, Xin Zheng, Xiaoli Yang, Panpan Ma,Ying Cai,Bangzhi Zhangb,and Yuan Chen"	Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity
DRAMP20979	KLLKWWKKLL	10	Anoplin-3 (Derived from  Anoplin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25316570]Gram-positive bacteria : Staphylococcus aureus (MIC=16 ¦Ìg/ml), bacillus subtilis (MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli (MIC=16 ¦Ìg/ml), Peudomonas eruginosa (MIC=8 ¦Ìg/ml)"	"[Ref.25316570] 0% hemolysis at 12.5 ¦Ìg/ml , 0.5% hemolysis at 25 ¦Ìg/ml , 0.5% hemolysis at 50 ¦Ìg/ml , 4% hemolysis at 100 ¦Ìg/ml , 14% hemolysis at 200 ¦Ìg/ml against mice red blood cells"	Linear	Free	Amidation	None	L	[Ref.25316570] No cytotoxicity information found	Not found	25316570	J Pept Sci. 2014 Dec;20(12):945-51. doi: 10.1002/psc.2705.	"Yang Wang, Jianbo Chen, Xin Zheng, Xiaoli Yang, Panpan Ma,Ying Cai,Bangzhi Zhangb,and Yuan Chen"	Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity
DRAMP20980	kllkwwkkll	10	Anoplin-4 (Derived from  Anoplin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25316570]Gram-positive bacteria : Staphylococcus aureus (MIC=8 ¦Ìg/ml), bacillus subtilis (MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli (MIC=8 ¦Ìg/ml), Peudomonas eruginosa (MIC=8 ¦Ìg/ml)"	"[Ref.25316570] 0.5% hemolysis at 12.5 ¦Ìg/ml , 0.5% hemolysis at 25 ¦Ìg/ml , 2% hemolysis at 50 ¦Ìg/ml , 1% hemolysis at 100 ¦Ìg/ml , 4% hemolysis at 200 ¦Ìg/ml against mice red blood cells"	Linear	Free	Amidation	None	D	[Ref.25316570] No cytotoxicity information found	Not found	25316570	J Pept Sci. 2014 Dec;20(12):945-51. doi: 10.1002/psc.2705.	"Yang Wang, Jianbo Chen, Xin Zheng, Xiaoli Yang, Panpan Ma,Ying Cai,Bangzhi Zhangb,and Yuan Chen"	Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity
DRAMP20981	GFGSLLGKALRLGANVL	17	"CPF-C1 (Frogs, Amphibians, Animals)"	No entry found	Not found	Not found	Tetraploid frog Xenopus clivii	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Not found	"Random coil, alpha helix"	"CPF-C1 revealed a random coil structure in PBS, displayed typical "	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=4 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=32 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 ¦Ìg/ml), Escherichia coli 780 (MIC=8 ¦Ìg/ml), Escherichia coli 804 (MIC=8 ¦Ìg/ml), Escherichia coli 850 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=128 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=64 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=4 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=16 ¦Ìg/ml)"	"[Ref.28371431] 0% hemolysis at 32 ¦Ìg/ml , 5% hemolysis at 64 ¦Ìg/ml , 7% hemolysis at 128 ¦Ìg/ml , 15% hemolysis at 256 ¦Ìg/ml , 57% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20982	KFWSLLKKALRLWANVL	17	CPF-1 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	CPF-1 displayed typical 	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=16 ¦Ìg/ml), Escherichia coli 780 (MIC=16 ¦Ìg/ml), Escherichia coli 804 (MIC=32 ¦Ìg/ml), Escherichia coli 850 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=64 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=16 ¦Ìg/ml)"	"[Ref.28371431] 0% hemolysis at 0 ¦Ìg/ml , 5% hemolysis at 4 ¦Ìg/ml , 8% hemolysis at 8 ¦Ìg/ml , 20% hemolysis at 16 ¦Ìg/ml , 35% hemolysis at 32 ¦Ìg/ml , 58% hemolysis at 64 ¦Ìg/ml , 70% hemolysis at 128 ¦Ìg/ml , 78% hemolysis at 256 ¦Ìg/ml , 80% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20983	kFwSLLkKALRLwANVL	17	CPF-2 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	CPF-2 displayed typical 	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 ¦Ìg/ml), Escherichia coli 780 (MIC=8 ¦Ìg/ml), Escherichia coli 804 (MIC=8 ¦Ìg/ml), Escherichia coli 850 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=16 ¦Ìg/ml)"	"[Ref.28371431] 0% hemolysis at 4 ¦Ìg/ml , 5% hemolysis at 8 ¦Ìg/ml , 8% hemolysis at 16 ¦Ìg/ml , 24% hemolysis at 32 ¦Ìg/ml , 48% hemolysis at 64 ¦Ìg/ml , 68% hemolysis at 128 ¦Ìg/ml , 85% hemolysis at 256 ¦Ìg/ml , 90% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Lys1, D-Trp3, D-Lys7, D-Trp13)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20984	KFWKLLKKALRLWAKVL	17	CPF-3 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	CPF-3 displayed typical 	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 ¦Ìg/ml), Escherichia coli 780 (MIC=8 ¦Ìg/ml), Escherichia coli 804 (MIC=8 ¦Ìg/ml), Escherichia coli 850 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=16 ¦Ìg/ml)"	"[Ref.28371431] 0% hemolysis at 256 ¦Ìg/ml , 5% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20985	kFWKlLKkAlrLWAkVL	17	CPF-4 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=16 ¦Ìg/ml), Escherichia coli 780 (MIC=16 ¦Ìg/ml), Escherichia coli 804 (MIC=16 ¦Ìg/ml), Escherichia coli 850 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=32 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=16 ¦Ìg/ml)"	"[Ref.28371431] 0% hemolysis at 32 ¦Ìg/ml , 5% hemolysis at 64 ¦Ìg/ml , 8% hemolysis at 128 ¦Ìg/ml , 10% hemolysis at 256 ¦Ìg/ml , 25% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Lys1, D-Leu5, D-Lys8, D-Leu10, D-Arg11, D-Lys15)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20986	kFwKLLkKALrLwAkVL	17	CPF-5 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 ¦Ìg/ml), Escherichia coli 780 (MIC=8 ¦Ìg/ml), Escherichia coli 804 (MIC=8 ¦Ìg/ml), Escherichia coli 850 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=8 ¦Ìg/ml)"	"[Ref.28371431] 0% hemolysis at 16 ¦Ìg/ml , 5% hemolysis at 32 ¦Ìg/ml , 10% hemolysis at 64 ¦Ìg/ml , 20% hemolysis at 128 ¦Ìg/ml , 40% hemolysis at 256 ¦Ìg/ml , 37% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Lys1, D-Trp3, D-Lys7, D-Arg11, D-Trp13, D-Lys15)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20987	lFwKLLlKAlrLwAkVL	17	CPF-6 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=16 ¦Ìg/ml), Escherichia coli 780 (MIC=16 ¦Ìg/ml), Escherichia coli 804 (MIC=16 ¦Ìg/ml), Escherichia coli 850 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=64 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC8=¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=8 ¦Ìg/ml)"	"[Ref.28371431] 0% hemolysis at 4 ¦Ìg/ml , 3% hemolysis at 8 ¦Ìg/ml , 17.5% hemolysis at 16 ¦Ìg/ml , 45% hemolysis at 32 ¦Ìg/ml , 70% hemolysis at 64 ¦Ìg/ml , 80% hemolysis at 128 ¦Ìg/ml , 85% hemolysis at 256 ¦Ìg/ml , 90% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Leu1, D-Trp3, D-Leu7, D-Leu10, D-Arg11, D-Trp13, D-Lys15)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20988	WFKKLLKKALRLWKKVL	17	CPF-7 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	CPF-7 displayed typical 	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=16 ¦Ìg/ml), Escherichia coli 780 (MIC=16 ¦Ìg/ml), Escherichia coli 804 (MIC=16 ¦Ìg/ml), Escherichia coli 850 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=32 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=16 ¦Ìg/ml)"	"[Ref.28371431] 0% hemolysis at 4 [Ref.28371431] 0% hemolysis at 4 ¦Ìg/ml , 5% hemolysis at 8 ¦Ìg/ml , 23% hemolysis at 16 ¦Ìg/ml , 50% hemolysis at 32 ¦Ìg/ml , 70% hemolysis at 64 ¦Ìg/ml , 95% hemolysis at 128 ¦Ìg/ml , 90% hemolysis at 256 ¦Ìg/ml , 100% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20989	wFKKlLKkAlrLWKkVL	17	CPF-8 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 ¦Ìg/ml), Escherichia coli 780 (MIC=8 ¦Ìg/ml), Escherichia coli 804 (MIC=8 ¦Ìg/ml), Escherichia coli 850 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=8 ¦Ìg/ml)"	"[Ref.28371431]13% hemolysis at 4 ¦Ìg/ml , 5% hemolysis at 8 ¦Ìg/ml , 0% hemolysis at 16 ¦Ìg/ml , 0% hemolysis at 32 ¦Ìg/ml , 0% hemolysis at 64 ¦Ìg/ml , 0% hemolysis at 128 ¦Ìg/ml , 0% hemolysis at 256 ¦Ìg/ml , 0% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Trp1, D-Leu5, D-Lys8, D-Leu10, D-Arg11, D-Lys15)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20990	kFwKLLkKAlrLwKkVL	17	CPF-9 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 ¦Ìg/ml), Escherichia coli 780 (MIC=8 ¦Ìg/ml), Escherichia coli 804 (MIC=8 ¦Ìg/ml), Escherichia coli 850 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=64 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=8 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=8 ¦Ìg/ml)"	"[Ref.28371431]0% hemolysis at 256 ¦Ìg/ml , 5% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Lys1, D-Trp3, D-Lys7, D-Leu10, D-Arg11, D-Trp13, D-Lys15)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20991	wFwKLLwKAlrLwWkVL	17	CPF-10 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=16 ¦Ìg/ml), Escherichia coli 780 (MIC=16 ¦Ìg/ml), Escherichia coli 804 (MIC=32 ¦Ìg/ml), Escherichia coli 850 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=256 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=16 ¦Ìg/ml)"	"[Ref.28371431]0% hemolysis at 4 ¦Ìg/ml , 5% hemolysis at 8 ¦Ìg/ml , 21% hemolysis at 16 ¦Ìg/ml , 40% hemolysis at 32 ¦Ìg/ml , 56% hemolysis at 64 ¦Ìg/ml , 65% hemolysis at 128 ¦Ìg/ml , 73% hemolysis at 256 ¦Ìg/ml , 85% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Trp1, D-Trp3, D-Trp7, D-Leu10, D-Arg11, D-Trp13, D-Lys15)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20992	lLKkAlrLWKkVL	13	CPF-11 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=64 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=32 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=64 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=32 ¦Ìg/ml), Escherichia coli 780 (MIC=16 ¦Ìg/ml), Escherichia coli 804 (MIC=16 ¦Ìg/ml), Escherichia coli 850 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=128 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=64 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=64 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=32 ¦Ìg/ml)"	"[Ref.28371431]2% hemolysis at 4 ¦Ìg/ml , 3% hemolysis at 8 ¦Ìg/ml , 1% hemolysis at 16 ¦Ìg/ml , 0% hemolysis at 32 ¦Ìg/ml , 0% hemolysis at 64 ¦Ìg/ml , 0% hemolysis at 128 ¦Ìg/ml , 10% hemolysis at 256 ¦Ìg/ml , 20% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Leu1, D-Lys4, D-Leu6, D-Arg7, D-Lys11)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20993	LLwKAlrLwWkVL	13	CPF-12 (Derived from  CPF-C1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28371431]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 725 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 794 (MIC=16 ¦Ìg/ml), Staphylococcuss aureus 936 (MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=16 ¦Ìg/ml), Escherichia coli 780 (MIC=16 ¦Ìg/ml), Escherichia coli 804 (MIC=32 ¦Ìg/ml), Escherichia coli 850 (MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=64 ¦Ìg/ml), Pseudomonas aeruginosa 2760 (MIC=64 ¦Ìg/ml), Pseudomonas aeruginosa 9132 (MIC>256 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 1980 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 2982 (MIC=16 ¦Ìg/ml), Acinetobacter baumannii 4956 (MIC=16 ¦Ìg/ml)"	"[Ref.28371431]0% hemolysis at 4 ¦Ìg/ml , 3% hemolysis at 8 ¦Ìg/ml , 0% hemolysis at 16 ¦Ìg/ml , 0% hemolysis at 32 ¦Ìg/ml , 0% hemolysis at 64 ¦Ìg/ml , 3% hemolysis at 128 ¦Ìg/ml , 8% hemolysis at 256 ¦Ìg/ml , 38% hemolysis at 512 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	"Mixed(D-Trp3, D-Leu6, D-Arg7, D-Trp9, D-Lys11)"	[Ref.28371431] No cytotoxicity information found	Not found	28371431	Chem Biol Drug Des. 2017 Nov;90(5):690-702. doi: 10.1111/cbdd.12988.	"Junqiu Xie,Qian Zhao,Sisi Li,Zhibin Yan,Jing Li,Yao Li,Lingyun Mou,Bangzhi Zhang,Wenle Yang,Xiaokang Miao,Xianxing Jiang,and Rui Wang"	Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria
DRAMP20994	GLLKFIKKLL	10	anoplin analog 4	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida parapsilosis"	"[Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=15 ¦Ìg/ml), Bacillus subtilis DELTA (MIC=30 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli DH5a (MIC=300 ¦Ìg/ml), Zymomonas mobilis 10988 (MIC=7 ¦Ìg/ml);##Fungi : Candida parapsilosis (MIC=40 ¦Ìg/ml)"	"[Ref.27862650]0% hemolysis at 55¦Ìg/ml , 7% hemolysis at 100¦Ìg/ml , 17% hemolysis at 200¦Ìg/ml , 24% hemolysis at 300 ¦Ìg/ml , 33% hemolysis at 400¦Ìg/ml , 35% hemolysis at 500 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.27862650] No cytotoxicity information found	Not found	27862650	J Pept Sci. 2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.	"Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis"	Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin
DRAMP20995	KLLKFIKKLL	10	anoplin analog 5	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida parapsilosis"	"[Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=15 ¦Ìg/ml), Bacillus subtilis DELTA (MIC=40 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli DH5a (MIC=400 ¦Ìg/ml), Zymomonas mobilis 10988 (MIC=10 ¦Ìg/ml);##Fungi : Candida parapsilosis (MIC=30 ¦Ìg/ml)"	"[Ref.27862650]0% hemolysis at 100 ¦Ìg/ml , 4% hemolysis at 200 ¦Ìg/ml , 11% hemolysis at 300 ¦Ìg/ml , 13% hemolysis at 400 ¦Ìg/ml , 15% hemolysis at 500 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.27862650] No cytotoxicity information found	Not found	27862650	J Pept Sci. 2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.	"Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis"	Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin
DRAMP20996	RLLKFIKKLL	10	anoplin analog 6	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida parapsilosis"	"[Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=20 ¦Ìg/ml), Bacillus subtilis DELTA (MIC=40 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli DH5a (MIC=400 ¦Ìg/ml), Zymomonas mobilis 10988 (MIC=10 ¦Ìg/ml);##Fungi : Candida parapsilosis (MIC=30 ¦Ìg/ml)"	"[Ref.27862650]0% hemolysis at 300 ¦Ìg/ml , 3% hemolysis at 400 ¦Ìg/ml , 12% hemolysis at 500 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.27862650] No cytotoxicity information found	Not found	27862650	J Pept Sci. 2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.	"Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis"	Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin
DRAMP20997	GLLKFIKKLL	10	anoplin analog 7	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli DH5a (MIC=30 ¦Ìg/ml), Pseudomonas aeruginosa PAO (MIC=5 ¦Ìg/ml), Zymomonas mobilis 10988 (MIC=5 ¦Ìg/ml)"	"[Ref.27862650]3% hemolysis at 100 ¦Ìg/ml , 5% hemolysis at 200 ¦Ìg/ml , 9% hemolysis at 300 ¦Ìg/ml , 8% hemolysis at 400 ¦Ìg/ml , 7% hemolysis at 500 ¦Ìg/ml against human red blood cells"	Linear	Acylation (Conjugated with octanoic acid)	Amidation	None	L	[Ref.27862650] No cytotoxicity information found	Not found	27862650	J Pept Sci. 2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.	"Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis"	Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin
DRAMP20998	GLLKFIKKLL	10	anoplin analog 8	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli DH5a (MIC=30 ¦Ìg/ml), Pseudomonas aeruginosa PAO (MIC=5 ¦Ìg/ml), Zymomonas mobilis 10988 (MIC=5 ¦Ìg/ml)"	"[Ref.27862650]10% hemolysis at 50 ¦Ìg/ml , 12% hemolysis at 100 ¦Ìg/ml , 10% hemolysis at 400 ¦Ìg/ml , 11% hemolysis at 500 ¦Ìg/ml against human red blood cells"	Linear	Acylation (Conjugated with decanoic acid) 	Amidation	None	L	[Ref.27862650] No cytotoxicity information found	Not found	27862650	J Pept Sci. 2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.	"Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis"	Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin
DRAMP20999	GLLKFIKKLL	10	anoplin analog 9	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27862650]Gram-positive bacteria : Mycobacteria smegmatis mc2 155 (MIC=5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli DH5a (MIC=40 ¦Ìg/ml), Pseudomonas aeruginosa PAO (MIC=5 ¦Ìg/ml), Zymomonas mobilis 10988 (MIC=30 ¦Ìg/ml)"	"[Ref.27862650]10% hemolysis at 50 ¦Ìg/ml , 12% hemolysis at 100 ¦Ìg/ml , 10% hemolysis at 400 ¦Ìg/ml , 11% hemolysis at 500 ¦Ìg/ml against human red blood cells"	Linear	Acylation (Conjugated with dodecanoic acid)	Amidation	None	L	[Ref.27862650] No cytotoxicity information found	Not found	27862650	J Pept Sci. 2016 Nov;22(11-12):731-736. doi: 10.1002/psc.2939.	"Kostas Chionis, Dimitrios Krikorian, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou-Pomonis"	Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin
DRAMP21000	GCRRLCYKQRCVTYCRGR	18	cGm (Derived from Gm)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 ¦ÌM), Escherichia coli CGSC 5167 (MIC=0.06 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MIC=4-8 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=1-2 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=1-4 ¦ÌM), Helicobacter pylori ATCC 43504 (MIC= ¦ÌM);##Fungi : Candida albicans ATCC 90028 (MIC=4-8 ¦ÌM), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 ¦ÌM)"	"[Ref.28741926] 5% hemolysis at 0.03 ¦ÌM , 0% hemolysis at 1.1 ¦ÌM , 10% hemolysis at 17 ¦ÌM , 50% hemolysis at 100¦ÌM against human red blood cells"	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bond between Cys2 and Cys15,Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 39.8 ¡À 1.0 ¦ÌM against CRL-1739, CC50 = 2.9 ¡À 0.1 ¦ÌM against MM96L, CC50 = 71.7 ¡À 9.2 ¦ÌM against HFF-1, CC50 > 64 ¦ÌM against HeLa, CC50 = 15.3 ¡À 1.4 ¦ÌM against MCF-7, CC50 = 2.7 ¡À 0.1 ¦ÌM against K-562, CC50 = 12.7 ¡À 1.1 ¦ÌM PBMCs."	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21001	GCRRLCWKQRCVTYCRGR	18	[Y7W]cGm (Derived from Gm)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1-2 ¦ÌM)	[Ref.28741926] 35.1-55.5% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 23.3 ¡À 0.4 ¦ÌM against CRL-1739, CC50 = 5.1 ¡À 0.3 ¦ÌM against MM96L, CC50 = 39.7 ¡À 3.8 ¦ÌM against HFF-1, CC50 > 64 ¦ÌM against HeLa, CC50 = 3.9 ¡À 0.2 ¦ÌM against K-562. "	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21002	GCRRLCYKQRCVTWCRGR	18	[Y14W]cGm (Derived from Gm) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1-2 ¦ÌM)	[Ref.28741926] 46.1-55.5% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 30.3 ¡À 1.1 ¦ÌM against CRL-1739, CC50 = 4.0 ¡À 0.1 ¦ÌM against MM96L, CC50 = 68.4 ¡À 9.6 ¦ÌM against HFF-1, CC50 = 50.4 ¡À 2.4 ¦ÌM against HeLa, CC50 = 2.7 ¡À 0.1 ¦ÌM against K-562. "	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21003	GCRRLCYRQRCVTYCRGR	18	[K8R]cGm (Derived from Gm) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1-2 ¦ÌM)	[Ref.28741926] 34.8-54.8% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 29.4 ¡À 1.1 ¦ÌM against CRL-1739, CC50 = 5.0 ¡À 0.3 ¦ÌM against MM96L, CC50 = 34.5 ¡À 3.6 ¦ÌM against HFF-1, CC50 = 39.4 ¡À 2.6 ¦ÌM against HeLa, CC50 = 3.1 ¡À 0.1 ¦ÌM against K-562."	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21004	GCRRLCWRQRCVTWCRGR	18	"[Y7W, K8R, Y14W]cGm (Derived from Gm) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1 ¦ÌM)	[Ref.28741926] 42-49.8% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 31.6 ¡À 1.3 ¦ÌM against CRL-1739, CC50 = 5.4 ¡À 0.3 ¦ÌM against MM96L, CC50 = 31.3 ¡À 2.6 ¦ÌM against HFF-1, CC50 = 41.0 ¡À 4.2 ¦ÌM against HeLa, CC50 = 15.1 ¡À 1.4 ¦ÌM against MCF-7, CC50 = 3.9 ¡À 0.1 ¦ÌM against K-562."	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21005	GCRALCYKQRCVTYCRGA	18	"[R4A, R18A]cGm (Derived from Gm) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 ¦ÌM), Escherichia coli CGSC 5167 (MIC=0.5-1 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MIC=32 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=8-16 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ¦ÌM), Helicobacter pylori ATCC 43504 (MIC>80 ¦ÌM);##Fungi : Candida albicans ATCC 90028 (MIC=32 ¦ÌM), Cryptococcus neoformans ATCC 208821 (MIC=8-16 ¦ÌM)"	"[Ref.28741926] 0% hemolysis at 17 ¦ÌM , 3% hemolysis at 35 ¦ÌM , 30-48.6% hemolysis at 64 ¦ÌM , 40% hemolysis at 100 ¦ÌM against human red blood cells"	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 > 64 ¦ÌM against CRL-1739, CC50 = 10.3 ¡À 1.1 ¦ÌM against MM96L, CC50 = 51.2 ¡À 4.0 ¦ÌM against HFF-1, CC50 > 64 ¦ÌM against HeLa, CC50 = 48.4 ¡À 0.7 ¦ÌM against MCF-7, CC50 = 11.5 ¡À 0.6 ¦ÌM against K-562, CC50 = 34.1 ¡À 3.9 ¦ÌM against HL-60;CC50=30.8 ¡À 2.5¦ÌM against PBMCs."	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21006	KCRRLCYRQRCVTYCRGR	18	"[G1K, K8R]cGm (Derived from Gm) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=0.5-1 ¦ÌM), Escherichia coli CGSC 5167 (MIC<0.015 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MIC=8 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=1-2 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC<0.25 ¦ÌM), Helicobacter pylori ATCC 43504 (MIC>80 ¦ÌM);##Fungi : Candida albicans ATCC 90028 (MIC=2 ¦ÌM), Cryptococcus neoformans ATCC 208821 (MIC=0.125-0.25 ¦ÌM)"	"[Ref.28741926] 0% hemolysis at 0.5 ¦ÌM , 2.5% hemolysis at 0.6 ¦ÌM , 20% hemolysis at 8 ¦ÌM , 43.3-56.9% hemolysis at 64 ¦ÌM , 50% hemolysis at 100 ¦ÌM against human red blood cells"	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 19.5 ¡À 0.5 ¦ÌM against CRL-1739, CC50 = 1.7 ¡À 0.1 ¦ÌM against MM96L, CC50 = 9.0 ¡À 0.5 ¦ÌM against HFF-1, CC50 = 44.2 ¡À 2.2¦ÌM against HeLa, CC50 = 6.7 ¡À 0.7 ¦ÌM against MCF-7, CC50 = 2.1 ¡À 0.2 ¦ÌM against K-562, CC50 = 9.0 ¡À 1.1¦ÌM against HL-60;CC50=5.1 ¡À 0.3¦ÌM against PBMCs."	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21007	GURRLUYKQRUVTYURGR	18	[C/U]cGm (Derived from Gm) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4-8 ¦ÌM), Escherichia coli CGSC 5167 (MIC=0.03-0.06 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MIC=8-16 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=4 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=2-4 ¦ÌM), Helicobacter pylori ATCC 43504 (MIC>80 ¦ÌM);##Fungi : Candida albicans ATCC 90028 (MIC=4-8 ¦ÌM), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 ¦ÌM)"	[Ref.28741926] 32.3-33.3% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between SeCys2 and SeCys15, SeCys6 and SeCys11. The 'U' in sequence is SelenoCys."	L	"[Ref.28741926] CC50 = 51.0 ¡À 4.6 ¦ÌM against CRL-1739, CC50 = 4.6 ¡À 0.2 ¦ÌM against MM96L, CC50 = 15.6 ¡À 3.6 ¦ÌM against HFF-1, CC50 > 64 ¦ÌM against HeLa, CC50 = 37.5 ¡À 3.3 ¦ÌM against MCF-7, CC50 = 1.4 ¡À 0.2 ¦ÌM against K-562, CC50 = 38.5 ¡À 4.8 ¦ÌM against HL-60;CC50=15.5 ¡À 0.8¦ÌM against PBMCs."	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21008	GCRRWCYKQRCVTYCRGR	18	[L5W]cGm (Derived from Gm) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria	[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8-16 ¦ÌM)	[Ref.28741926] 36.8-43.4% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 18.3 ¡À 1.4 ¦ÌM against CRL-1739, CC50 = 4.0 ¡À 0.1 ¦ÌM against MM96L, CC50 = 25.0 ¡À 2.9 ¦ÌM against HFF-1, CC50 = 17.1 ¡À 0.7 ¦ÌM against HeLa, CC50 = 1.0 ¡À 0.1 ¦ÌM against K-562. "	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21009	GCRRLCYKQRCVTYCRGpPR	20	[D-P L-P]cGm (Derived from Gm) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MIC=1-4 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=1-4 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ¦ÌM);##Fungi : Candida albicans ATCC 90028 (MIC=8 ¦ÌM), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 ¦ÌM)"	[Ref.28741926] 41.5-44.9% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 22.5 ¡À 3.3 ¦ÌM against CRL-1739, CC50 = 3.0 ¡À 0.1 ¦ÌM against MM96L, CC50 = 14.9 ¡À 0.8 ¦ÌM against HFF-1, CC50 = 51.5 ¡À 3.9 ¦ÌM against HeLa, CC50 = 3.9 ¡À 0.2 ¦ÌM against K-562, CC50 = 14.1 ¡À 0.9 ¦ÌM against PBMCs"	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21010	KCRRYCYRQRCVTYCRGR	18	"[G1K, L5Y, K8R]cGm (Derived from Gm) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=0.5-1 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MIC=4-8 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=1-2 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC<0.25-0.5 ¦ÌM);##Fungi : Candida albicans ATCC 90028 (MIC=4 ¦ÌM), Cryptococcus neoformans ATCC 208821 (MIC=0.5 ¦ÌM)"	[Ref.28741926] 20.6-32% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11."	L	"[Ref.28741926] CC50 = 26.5 ¡À 2.4 ¦ÌM against CRL-1739, CC50 = 2.0 ¡À 0.1 ¦ÌM against MM96L, CC50 = 14.7 ¡À 1.5 ¦ÌM against HFF-1, CC50 = 20.9 ¡À 1.4 ¦ÌM against HeLa, CC50 = 15.2 ¡À 1.9 ¦ÌM against MCF-7, CC50 = 1.3 ¡À 0.1 ¦ÌM against K-562, CC50 = 15.7 ¡À1.1¦ÌM against HL-60;CC50=10.4 ¡À 1.0¦ÌM against PBMCs."	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21011	KURRYUYRQRUVTYURGR	18	"[C/U, G1K, L5Y, K8R]cGm (Derived from Gm)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1-2 ¦ÌM), Klebsiella pneumoniae ATCC 700603 (MIC=4-16 ¦ÌM), Acinetobacter baumannii ATCC 19606 (MIC=1-2 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ¦ÌM);##Fungi : Candida albicans ATCC 90028 (MIC=4 ¦ÌM), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 ¦ÌM)"	[Ref.28741926] 17.8-24% hemolysis at 64 ¦ÌM against human red blood cells	Cyclic	No specific N-terminal	No specific C-terminal	"Disulfide bonds between SeCys2 and SeCys15, SeCys6 and SeCys11. The 'U' in sequence is SelenoCys."	L	"[Ref.28741926] CC50 = 46.2 ¡À 7.6 ¦ÌM against CRL-1739, CC50 = 2.3 ¡À 0.2 ¦ÌM against MM96L, CC50 = 30.8 ¡À 2.0 ¦ÌM against HFF-1, CC50 = 36.2 ¡À 2.8 ¦ÌM against HeLa, CC50 = 29.0 ¡À 3.7 ¦ÌM against MCF-7, CC50 = 6.4 ¡À 0.6 ¦ÌM against K-562, CC50 = 33.3 ¡À7.4¦ÌM against HL-60;CC50=9.5 ¡À 0.5¦ÌM against PBMCs."	Not found	28741926	ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?	"Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik"	Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
DRAMP21012	KILRGVCKKIMRTFLRRISKDILTGKK	27	"NK-2 (Mammals, Animals)"	No entry found	Not found	Not found	Mammal	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Not found	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.29043494]Gram-positive bacteria : Staphylococcus aureus (MIC=2 ¦ÌM), Staphylococcus epidermidis (MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=4 ¦ÌM), Pseudomonas aeruginosa (MIC=8 ¦ÌM)"	"[Ref.29043494] 2.5% hemolysis at 10 ¦Ìg/ml , 8% hemolysis at 25 ¦Ìg/ml , 22% hemolysis at 50 ¦Ìg/ml , 32.5% hemolysis at 75 ¦Ìg/ml , 36% hemolysis at 150 ¦Ìg/ml , 38% hemolysis at 300 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.29043494] IC50 = 25.1 ¦ÌM against NK-2. ##IC50 = 8.4 ¦ÌM against EJ. ##IC50 = 4.1 ¦ÌM against PC-3. ##IC50 = 10.1 ¦ÌM against T24. ##IC50 = 13.7  ¦ÌM against HL-60. ##The proliferation inhibition activity on K562 is not significant.	Not found	29043494	Probiotics Antimicrob Proteins. 2018 Mar;10(1):118-127. doi: 10.1007/s12602-017-9335-1.	Jiexi Yan & Xiaolei Liang & Chang Liu & Yuemei Cheng & Lanxia Zhou & Kairong Wang & Li Zhao	Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2
DRAMP21013	KILRGVCKKIMRPFLRRISKDILTGKK	27	NK-pro (Derived from NK-2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.29043494]Gram-positive bacteria : Staphylococcus aureus (MIC=4 ¦ÌM), Staphylococcus epidermidis (MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=4 ¦ÌM), Pseudomonas aeruginosa (MIC=16 ¦ÌM)"	"[Ref.29043494] 0.3% hemolysis at 10 ¦Ìg/ml , 2% hemolysis at 25 ¦Ìg/ml , 5.5% hemolysis at 50 ¦Ìg/ml , 8% hemolysis at 75 ¦Ìg/ml , 15% hemolysis at 150 ¦Ìg/ml , 28% hemolysis at 300 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.29043494] IC50 = 43.7 ¦ÌM against NK-2. ##IC50 = 23.3 ¦ÌM against EJ. ##IC50 = 9.3 ¦ÌM against PC-3. ##IC50 = 33.0 ¦ÌM against T24. ##IC50 = 26.1  ¦ÌM against HL-60. ####The proliferation inhibition activity on K562 is not significant.	Not found	29043494	Probiotics Antimicrob Proteins. 2018 Mar;10(1):118-127. doi: 10.1007/s12602-017-9335-1.	Jiexi Yan & Xiaolei Liang & Chang Liu & Yuemei Cheng & Lanxia Zhou & Kairong Wang & Li Zhao	Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2
DRAMP21014	KILPGVCKKIMRPFLRRISKDILTGKK	27	NK-dpro (Derived from NK-2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.29043494]Gram-positive bacteria : Staphylococcus aureus (MIC=8 ¦ÌM), Staphylococcus epidermidis (MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=8 ¦ÌM), Pseudomonas aeruginosa (MIC=32 ¦ÌM)"	"[Ref.29043494] 0% hemolysis at 10 ¦Ìg/ml , 2% hemolysis at 25 ¦Ìg/ml , 3% hemolysis at 50 ¦Ìg/ml , 4.5% hemolysis at 75 ¦Ìg/ml , 10% hemolysis at 150 ¦Ìg/ml , 20% hemolysis at 300 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.29043494] IC50 = 32.5 ¦ÌM against NK-2. ##IC50 = 28.7 ¦ÌM against EJ. ##IC50 = 9.6 ¦ÌM against PC-3. ##IC50 = 39.6 ¦ÌM against T24. ##IC50 = 48.4  ¦ÌM against HL-60. ##The proliferation inhibition activity on K562 is not significant.	Not found	29043494	Probiotics Antimicrob Proteins. 2018 Mar;10(1):118-127. doi: 10.1007/s12602-017-9335-1.	Jiexi Yan & Xiaolei Liang & Chang Liu & Yuemei Cheng & Lanxia Zhou & Kairong Wang & Li Zhao	Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2
DRAMP21015	RIGSILGALAKGLPTLISWIKNR	23	A (A1R) (Derived from AR-23)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=6.25 ¦ÌM), Staphylococcus epidermidis (MIC=3.13 ¦ÌM), Bacillus subtilis (MIC=6.25 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa (MIC=6.25 ¦ÌM), Klebsiella pneumoniae (MIC=12.5 ¦ÌM)"	[Ref.27271216] 100% hemolysis at  20¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 82%, 40%, 8%, 2% and almost 0% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 ¦ÌM."	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity
DRAMP21016	AIGSILGRLAKGLPTLISWIKNR	23	A (A8R) (Derived from AR-23)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=3.13 ¦ÌM), Staphylococcus epidermidis (MIC=3.13 ¦ÌM), Bacillus subtilis (MIC=3.13 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa (MIC=12.5 ¦ÌM), Klebsiella pneumoniae (MIC=12.5 ¦ÌM)"	"[Ref.27271216] 80% hemolysis at 20 ¦ÌM , 100% hemolysis at 40 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 97%, 58%, 10%, 2% and almost 0% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 ¦ÌM."	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity
DRAMP21017	AIGSILGALAKGLPTLKSWIKNR	23	A (I17K) (Derived from AR-23)  	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=50 ¦ÌM), Staphylococcus epidermidis (MIC=12.5 ¦ÌM), Bacillus subtilis (MIC=6.25 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=25 ¦ÌM), Pseudomonas aeruginosa (MIC=25 ¦ÌM), Klebsiella pneumoniae (MIC=50 ¦ÌM)"	"[Ref.27271216] 5% hemolysis at 20 ¦ÌM , 13% hemolysis at 40 ¦ÌM , 20% hemolysis at 60 ¦ÌM , 30% hemolysis at 80 ¦ÌM , 35% hemolysis at 100 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 98%, 92%, 53%, 34% and 7.9% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 ¦ÌM."	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity
DRAMP21018	AIGSILGALAKGLPTLRSWIKNR	23	A (I17R) (Derived from AR-23)  	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=25 ¦ÌM), Staphylococcus epidermidis (MIC=6.25 ¦ÌM), Bacillus subtilis (MIC=3.13 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa (MIC=12.5 ¦ÌM), Klebsiella pneumoniae (MIC=25 ¦ÌM)"	"[Ref.27271216] 10% hemolysis at 20 ¦ÌM , 15% hemolysis at 40 ¦ÌM , 20% hemolysis at 60 ¦ÌM , 30% hemolysis at 80 ¦ÌM , 35% hemolysis at 100 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 85%, 68%, 21% and 6.6% at peptide concentrations of 6.25, 12.5, 25 and 50 ¦ÌM. "	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity
DRAMP21019	RIGSILGRLAKGLPTLISWIKNR	23	"A (A1R, A8R) (Derived from AR-23)  "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=12.5 ¦ÌM), Staphylococcus epidermidis (MIC=3.13 ¦ÌM), Bacillus subtilis (MIC=6.25 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=6.25 ¦ÌM), Pseudomonas aeruginosa (MIC=6.25 ¦ÌM), Klebsiella pneumoniae (MIC=6.25 ¦ÌM)"	"[Ref.27271216] 58% hemolysis at 20 ¦ÌM , 80% hemolysis at 40 ¦ÌM , 100% hemolysis at 60 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 92%, 80%, 29%, 1% and almost 0% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 ¦ÌM."	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity
DRAMP21020	RIGSILGALAKGLPTLKSWIKNR	23	"A (A1R, I17K) (Derived from AR-23)  "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=100 ¦ÌM), Staphylococcus epidermidis (MIC=6.25 ¦ÌM), Bacillus subtilis (MIC=6.25 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=25 ¦ÌM), Pseudomonas aeruginosa (MIC=12.5 ¦ÌM), Klebsiella pneumoniae (MIC=25 ¦ÌM)"	"[Ref.27271216] 2% hemolysis at 20 ¦ÌM , 5% hemolysis at 40 ¦ÌM , 10% hemolysis at  60 ¦ÌM , 20% hemolysis at 80 ¦ÌM , 30% hemolysis at 100 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 95%, 92%, 60%, 33% and 24% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 ¦ÌM."	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	"Design of an Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"
DRAMP21021	AIGSILGRLAKGLPTLKSWIKNR	23	"A (A8R, I17K) (Derived from AR-23)  "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=100 ¦ÌM), Staphylococcus epidermidis (MIC=6.25 ¦ÌM), Bacillus subtilis (MIC=12.5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=25 ¦ÌM), Pseudomonas aeruginosa (MIC=25 ¦ÌM), Klebsiella pneumoniae (MIC=25 ¦ÌM)"	"[Ref.27271216] 2% hemolysis at 20 [Ref.27271216] 2% hemolysis at 20 ¦ÌM , 5% hemolysis at 40 ¦ÌM , 10% hemolysis at  60 ¦ÌM , 20% hemolysis at 80 ¦ÌM , 30% hemolysis at 100 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 100%, 99%, 92%, 64% and 21.1% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 ¦ÌM."	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity
DRAMP21022	RIGSILGRLAKGLPTLKSWIKNR	23	"A (A1R, A8R, I17K) (Derived from AR-23)  "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=100 ¦ÌM), Staphylococcus epidermidis (MIC=6.25 ¦ÌM), Bacillus subtilis (MIC=12.5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa (MIC=12.5 ¦ÌM), Klebsiella pneumoniae (MIC=12.5 ¦ÌM)"	"[Ref.27271216] 0% hemolysis at 40 ¦ÌM , 1% hemolysis at 60 ¦ÌM , 2% hemolysis at  80 ¦ÌM , 2% hemolysis at 100 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 96%, 95%, 92%, 68% and 31.4% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 ¦ÌM"	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity
DRAMP21023	RIGSILGRLAKGLPTLRSWIKNR	23	"A (A1R, A8R, I17R) (Derived from AR-23) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=100 ¦ÌM), Staphylococcus epidermidis (MIC=3.13 ¦ÌM), Bacillus subtilis (MIC=12.5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MIC=12.5 ¦ÌM), Pseudomonas aeruginosa (MIC=12.5 ¦ÌM), Klebsiella pneumoniae (MIC=12.5 ¦ÌM)"	"[Ref.27271216] 4% hemolysis at 40 ¦ÌM , 10% hemolysis at 60 ¦ÌM , 15% hemolysis at 80 ¦ÌM , 20% hemolysis at 100 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27271216] In L929 cells, the cell viability is 92%, 92%, 80%, 60% and 12% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 ¦ÌM "	Not found	27271216	Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394.	"Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji"	Design of an ¦Á-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity
DRAMP21024	FFSLIPSLVGGLISAFK	17	"Stigmurin (Tityus, Scorpionida, Arachnida)"	No entry found	Not found	Not found	Scorpion Tityus stigmurus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida glabrata, Candida krusei"	"[Ref.30709056]Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=9.4 ¦ÌM), Staphylococcus epidermidis (ATCC 12228)(MIC=9.4 ¦ÌM), Enterococcus faecalis (ATCC 4028)(MIC>150 ¦ÌM);##Gram-negative bacteria : Pseudomonas aeruginosa (ATCC 27853)(MIC>150 ¦ÌM), Escherichia coli (ATCC 25922)(MIC>150 ¦ÌM), Enterobacter cloacae (ATCC 13047)(MIC>150 ¦ÌM);##Fungi : Candida albicans (ATCC 90028)(MIC=37.5 ¦ÌM), Candida glabrata (ATCC 90030)(MIC>150 ¦ÌM), Candida krusei (ATCC 6258)(MIC>150 ¦ÌM)"	"[Ref.30709056] 7% hemolysis at 1.2 ¦Ìg/ml , 4% hemolysis at 2.3 ¦Ìg/ml , 2% hemolysis at 4.7 ¦Ìg/ml , 0% hemolysis at 9.4 ¦Ìg/ml , 3% hemolysis at 18.8 ¦Ìg/ml , 2% hemolysis at 37.5 ¦Ìg/ml , 3% hemolysis at 75 ¦Ìg/ml , 5% hemolysis at 150 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.30709056] No cytotoxicity information found.	Not found	30709056	Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.	"Bruno Amorim-Carmo , Alessandra Daniele-Silva , Adriana M. S. Parente ,Allanny A. Furtado , Eneas Carvalho , Johny W. F. Oliveira , Elizabeth C. G. Santos , Marcelo S. Silva , S¨¦rgio R. B. Silva , Arn¨®bio A. Silva-J¨²nior , Norberto K. Monteiro and Matheus F. Fernandes-Pedrosa"	Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin
DRAMP21025	FFSLIPSLVKKLIKAFK	17	StigA25 (Derived from Stigmurin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida glabrata, Candida krusei"	"[Ref.30709056]Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=1.2 ¦ÌM), Staphylococcus epidermidis (ATCC 12228)(MIC=2.3 ¦ÌM), Enterococcus faecalis (ATCC 4028)(MIC=4.7 ¦ÌM);##Gram-negative bacteria : Pseudomonas aeruginosa (ATCC 27853)(MIC=4.7 ¦ÌM), Escherichia coli (ATCC 25922)(MIC=2.3 ¦ÌM), Enterobacter cloacae (ATCC 13047)(MIC=18.8 ¦ÌM);##Fungi : Candida albicans (ATCC 90028)(MIC=9.4 ¦ÌM), Candida glabrata (ATCC 90030)(MIC=9.4 ¦ÌM), Candida krusei (ATCC 6258)(MIC=9.4 ¦ÌM)"	"[Ref.30709056] 1% hemolysis at 1.2 ¦Ìg/ml , 5% hemolysis at 2.3 ¦Ìg/ml , 9% hemolysis at 4.7 ¦Ìg/ml , 19% hemolysis at 9.4 ¦Ìg/ml , 33% hemolysis at 18.8 ¦Ìg/ml , 60% hemolysis at 37.5 ¦Ìg/ml , 78% hemolysis at 75 ¦Ìg/ml , 93% hemolysis at 150 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.30709056] No cytotoxicity information found.	Not found	30709056	Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.	"Bruno Amorim-Carmo , Alessandra Daniele-Silva , Adriana M. S. Parente ,Allanny A. Furtado , Eneas Carvalho , Johny W. F. Oliveira , Elizabeth C. G. Santos , Marcelo S. Silva , S¨¦rgio R. B. Silva , Arn¨®bio A. Silva-J¨²nior , Norberto K. Monteiro and Matheus F. Fernandes-Pedrosa"	Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin
DRAMP21026	FFKLIPKLVKKLIKAFK	17	StigA31 (Derived from Stigmurin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida glabrata, Candida krusei"	"[Ref.30709056]Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=2.3 ¦ÌM), Staphylococcus epidermidis (ATCC 12228)(MIC=2.3 ¦ÌM), Enterococcus faecalis (ATCC 4028)(MIC=1.2 ¦ÌM);##Gram-negative bacteria : Pseudomonas aeruginosa (ATCC 27853)(MIC=2.3 ¦ÌM), Escherichia coli (ATCC 25922)(MIC=1.2 ¦ÌM), Enterobacter cloacae (ATCC 13047)(MIC=4.7 ¦ÌM);##Fungi : Candida albicans (ATCC 90028)(MIC=4.7 ¦ÌM), Candida glabrata (ATCC 90030)(MIC=4.7 ¦ÌM), Candida krusei (ATCC 6258)(MIC=4.7 ¦ÌM)"	"[Ref.30709056] 1% hemolysis at 1.2 ¦Ìg/ml , 6% hemolysis at 2.3 ¦Ìg/ml , 10% hemolysis at 4.7 ¦Ìg/ml , 12 % hemolysis at 9.4 ¦Ìg/ml , 23% hemolysis at 18.8 ¦Ìg/ml , 45% hemolysis at 37.5 ¦Ìg/ml , 65% hemolysis at 75 ¦Ìg/ml , 70% hemolysis at 150 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.30709056] No cytotoxicity information found.	Not found	30709056	Int J Mol Sci. 2019 Jan 31;20(3). pii: E623. doi: 10.3390/ijms20030623.	"Bruno Amorim-Carmo , Alessandra Daniele-Silva , Adriana M. S. Parente ,Allanny A. Furtado , Eneas Carvalho , Johny W. F. Oliveira , Elizabeth C. G. Santos , Marcelo S. Silva , S¨¦rgio R. B. Silva , Arn¨®bio A. Silva-J¨²nior , Norberto K. Monteiro and Matheus F. Fernandes-Pedrosa"	Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin
DRAMP21027	ALWKKILKNAGKAALNKINQIVQ	23	"K5, 17-DPS3 (Derived from dermaseptin-PS3 (DPS3))"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix"	"These three peptides existed in random coils in aqueous solution, they all adopted "	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	[Ref.30087268]Gram-positive bacteria : Staphylococcuss aureus (NCTC 10788)(MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli (NCTC 10418)(MIC=8 ¦ÌM);##Fungi : Candida albicans (NCYC 1467)(MIC=4 ¦ÌM)	"[Ref.30087268] 8% hemolysis at 0 ¦ÌM , 40% hemolysis at 1 ¦ÌM , 90% hemolysis at 2 ¦ÌM against horse red blood cells"	Linear	Free	Amidation	None	L	[Ref.30087268] IC50 = 18.20 ¦ÌM for H157. ##IC50 = 18.20 ¦ÌM for PC3. ##IC50 = 132.10 ¦ÌM for HMEC-1	Not found	30087268	Toxins (Basel). 2018 Aug 7;10(8). pii: E320. doi: 10.3390/toxins10080320.	"Yining Tan ,Xiaoling Chen , Chengbang Ma , Xinping Xi ,Lei Wang , Mei Zhou ,James F. Burrows ,Hang Fai Kwok 2 ID and Tianbao Chen"	"Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii"
DRAMP21028	ALWKDILKNLLKAALNEINQIVQ	23	"L10, 11-DPS3 (Derived from dermaseptin-PS3 (DPS3))"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix"	"These three peptides existed in random coils in aqueous solution, they all adopted "	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	[Ref.30087268]Gram-positive bacteria : Staphylococcuss aureus (NCTC 10788)(MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli (NCTC 10418)(MIC=16 ¦ÌM);##Fungi : Candida albicans (NCYC 1467)(MIC=16 ¦ÌM)	"[Ref.30087268] 20% hemolysis at 0 ¦ÌM , 70% hemolysis at 1 ¦ÌM , 95% hemolysis at 2 ¦ÌM against horse red blood cells"	Linear	Free	Amidation	None	L	[Ref.30087268] IC50 = 0.12 ¦ÌM for H157. ##IC50 = 1.85 ¦ÌM for PC3. ##IC50 = 8.76 ¦ÌM for HMEC-1	Not found	30087268	Toxins (Basel). 2018 Aug 7;10(8). pii: E320. doi: 10.3390/toxins10080320.	"Yining Tan ,Xiaoling Chen , Chengbang Ma , Xinping Xi ,Lei Wang , Mei Zhou ,James F. Burrows ,Hang Fai Kwok 2 ID and Tianbao Chen"	"Yining Tan ,Xiaoling Chen , Chengbang Ma , Xinping Xi ,Lei Wang , Mei Zhou ,James F. Burrows ,Hang Fai Kwok 2 ID and Tianbao Chen"
DRAMP21029	ATYRTGRATRESLSGVEISGRLYRLR	26	D5R (Derived from HD5) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Alpha helix, beta sheet, beta turn"	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Saccharomyces cerevisiae"	"[Ref.26206286]Gram-positive bacteria : Staphylococcus aureus (NCTC 8530)(MIC=100 ¦ÌM), Bacillus subtilis (NCIM 2162)(MIC=20 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MG 1655)(MIC=50 ¦ÌM), Pseudomonas aeruginosa (NCTC 6750)(MIC=100 ¦ÌM);##Fungi : Candida albicans (ATCC 18804)(MIC=20 ¦ÌM), Saccharomyces cerevisiae (BY4741)(MIC=100 ¦ÌM)"	[Ref.26206286] 0% hemolysis at 100¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.26206286] No cytotoxic information found.	Not found	26206286	Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.	Basil Mathew Ramakrishnan Nagaraj	Antimicrobial activity of human-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs
DRAMP21030	ATYrTGrATrESLSGVEISGrLYrLR	26	D5r (Derived from HD5) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Alpha helix, beta sheet, beta turn"	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans"	"[Ref.26206286]Gram-positive bacteria : Staphylococcus aureus (NCTC 8530)(MIC=100 ¦ÌM), Bacillus subtilis (NCIM 2162)(MIC=50 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MG 1655)(MIC=50 ¦ÌM), Pseudomonas aeruginosa (NCTC 6750)(MIC=200 ¦ÌM);##Fungi : Candida albicans (ATCC 18804)(MIC=20 ¦ÌM)"	[Ref.26206286] 0% hemolysis at 100¦ÌM against human red blood cells	Linear	Free	Free	None	"Mixed(D-Arg4, D-Arg7, D-Arg10, D-Arg21, D-Arg24)"	[Ref.26206286] No cytotoxic information found.	Not found	26206286	Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.	Basil Mathew Ramakrishnan Nagaraj	Antimicrobial activity of human-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs
DRAMP21031	ATYRTGRATRESLSGVEISGRLYRLR	26	MyD5R (Derived from HD5) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Alpha helix, beta sheet, beta turn"	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Saccharomyces cerevisiae"	"[Ref.26206286]Gram-positive bacteria : Staphylococcus aureus (NCTC 8530)(MIC=7.5 ¦ÌM), Bacillus subtilis (NCIM 2162)(MIC=20 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MG 1655)(MIC=5 ¦ÌM), Pseudomonas aeruginosa (NCTC 6750)(MIC=10 ¦ÌM);##Fungi : Candida albicans (ATCC 18804)(MIC=10 ¦ÌM), Saccharomyces cerevisiae (BY4741)(MIC=20 ¦ÌM)"	"[Ref.26206286] 23% hemolysis at 10 ¦ÌM , 50% hemolysis at 20 ¦ÌM , 75% hemolysis at 50 ¦ÌM , 87.5% hemolysis at 100 ¦ÌM against human red blood cells"	Linear	Acylation (Conjugated with myristic acid)	Free	None	L	[Ref.26206286] No cytotoxic information found.	Not found	26206286	Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.	Basil Mathew Ramakrishnan Nagaraj	Antimicrobial activity of human-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs
DRAMP21032	ATYrTGrATrESLSGVEISGrLYrLR	26	MyD5r (Derived from HD5) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Alpha helix, beta sheet, beta turn"	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Saccharomyces cerevisiae"	"[Ref.26206286]Gram-positive bacteria : Staphylococcus aureus (NCTC 8530)(MIC=7.5 ¦ÌM), Bacillus subtilis (NCIM 2162)(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MG 1655)(MIC=5 ¦ÌM), Pseudomonas aeruginosa (NCTC 6750)(MIC=7.5 ¦ÌM);##Fungi : Candida albicans (ATCC 18804)(MIC=10 ¦ÌM), Saccharomyces cerevisiae (BY4741)(MIC=20 ¦ÌM)"	"[Ref.26206286] 17% hemolysis at 10 ¦ÌM , 25% hemolysis at 20 ¦ÌM , 50% hemolysis at 50 ¦ÌM , 70% hemolysis at 100 ¦ÌM against human red blood cells"	Linear	Acylation (Conjugated with myristic acid)	Free	None	"Mixed(D-Arg4, D-Arg7, D-Arg10, D-Arg21, D-Arg24)"	[Ref.26206286] No cytotoxic information found.	Not found	26206286	Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.	Basil Mathew Ramakrishnan Nagaraj	Antimicrobial activity of human-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs
DRAMP21033	ATYRTGRATRESLSGVEISGRLYRLR	26	LaD5R (Derived from HD5) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Alpha helix, beta sheet, beta turn"	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Saccharomyces cerevisiae"	"[Ref.26206286]Gram-positive bacteria : Staphylococcus aureus (NCTC 8530)(MIC=2 ¦ÌM), Bacillus subtilis (NCIM 2162)(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MG 1655)(MIC=20 ¦ÌM), Pseudomonas aeruginosa (NCTC 6750)(MIC=10 ¦ÌM);##Fungi : Candida albicans (ATCC 18804)(MIC=10 ¦ÌM), Saccharomyces cerevisiae (BY4741)(MIC=10 ¦ÌM)"	[Ref.26206286] 0% hemolysis at 100¦ÌM against human red blood cells	Linear	Acylation (Conjugated with lauric acid)	Free	None	L	[Ref.26206286] No cytotoxic information found.	Not found	26206286	Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.	Basil Mathew Ramakrishnan Nagaraj	Antimicrobial activity of human-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs
DRAMP21034	ATYrTGrATrESLSGVEISGrLYrLR	26	LaD5r (Derived from HD5) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Alpha helix, beta sheet, beta turn"	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Saccharomyces cerevisiae"	"[Ref.26206286]Gram-positive bacteria : Staphylococcus aureus (NCTC 8530)(MIC=20 ¦ÌM), Bacillus subtilis (NCIM 2162)(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (MG 1655)(MIC=10 ¦ÌM), Pseudomonas aeruginosa (NCTC 6750)(MIC=50 ¦ÌM);##Fungi : Candida albicans (ATCC 18804)(MIC=10 ¦ÌM), Saccharomyces cerevisiae (BY4741)(MIC=10 ¦ÌM)"	[Ref.26206286] 0% hemolysis at 100¦ÌM against human red blood cells	Linear	Acylation (Conjugated with lauric acid)	Free	None	"Mixed(D-Arg4, D-Arg7, D-Arg10, D-Arg21, D-Arg24)"	[Ref.26206286] No cytotoxic information found.	Not found	26206286	Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.	Basil Mathew Ramakrishnan Nagaraj	Antimicrobial activity of human-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs
DRAMP21035	KAAKAAKKAAKAAWK	15	AC-UM-14W (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26235946]Gram-positive bacteria : Bacillus subtilis (MIC>200 ¦Ìg/ml), Staphylococcus aureus (MIC>200 ¦Ìg/ml), Staphylococcus epidermis (MIC>200 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli (MIC>200 ¦Ìg/ml), Shigella dysentariae (MIC>200 ¦Ìg/ml), Salmonella typhimurium (MIC>200 ¦Ìg/ml), Klebsiella pneumonia (MIC>200 ¦Ìg/ml), Pseudomonas aeruginosa (MIC>200 ¦Ìg/ml)"	"[Ref.26235946] <1% hemolysis at 12.5 ¦ÌM , <1% hemolysis at 25 ¦ÌM against human red blood cells"	Linear	Acylation (Conjugated with acetyl group)	Amidation	None	L	[Ref.26235946] No cytotoxic information found.	Not found	26235946	Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. doi: 10.1016/j.bmcl.2015.06.053.	"Thuy T. T. Dinh , Do-Hee Kim , Huy X. Luong  , Bong-Jin Lee , Young-Woo Kim"	Antimicrobial activity of doubly-stapled alanine/lysine-based peptides
DRAMP21036	RWKIFKKIPKFLHSAKKF	18	PapMA (Derived from Papiliocin and Magainin 2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	PapMA and PapMA-k exhibited ¦Á-helical structures in 50 mM DPC micelles and 50% TFE/H2O but displayed unordered structures in aqueous solution.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26053120] Gram-positive bacteria : Bacillus subtilis(MIC=4.0 ¦ÌM), Enterococcus faecalis(MIC=16 ¦ÌM), Staphylococcus aureus(MIC=4.0 ¦ÌM), ;##Gram-negative bacteria : Escherichia coli(MIC=2.0 ¦ÌM), Pseudomonas aeruginosa(MIC=4.0 ¦ÌM), Salmonella typhimurium(MIC=4.0 ¦ÌM)"	[Ref.26053120] MHC=100 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26053120] IC50 = 10 ¦ÌM against mouse macrophage-derived RAW264.7 cells. ##IC50 = 9 ¦ÌM for NIH3T3 fibroblasts.	Not found	26053120	Biochemistry. 2015 Jun 30;54(25):3921-31. doi: 10.1021/acs.biochem.5b00392.	"Areum Shin, Eunjung Lee,  Dasom Jeon, Young-Guen Park, Jeong Kyu Bang, Yong-Sun Park, Song Yub Shin, and Yangmee Kim"	Peptoid-Substituted Hybrid Antimicrobial Peptide Derived from Papiliocin and Magainin 2 with Enhanced Bacterial Selectivity and Anti-inflammatory Activity
DRAMP21037	RWKIFKKIkKFLHSAKKF	18	PapMA-k (Derived from Papiliocin and Magainin 2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	PapMA and PapMA-k exhibited ¦Á-helical structures in 50 mM DPC micelles and 50% TFE/H3O but displayed unordered structures in aqueous solution.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26053120] Gram-positive bacteria : Bacillus subtilis(MIC=4.0 ¦ÌM), Enterococcus faecalis(MIC=16 ¦ÌM), Staphylococcus aureus(MIC=4.0 ¦ÌM), ;##Gram-negative bacteria : Escherichia coli(MIC=2.0 ¦ÌM), Pseudomonas aeruginosa(MIC=4.0 ¦ÌM), Salmonella typhimurium(MIC=2.0 ¦ÌM)"	[Ref.26053120] MHC=200 ¦ÌM against human red blood cells	Linear	Free	Amidation	The 'k'  in sequence is lysine peptoid	L	[Ref.26053120] IC50 = 42 ¦ÌM against mouse macrophage-derived RAW264.7 cells. ##IC50 = 39 ¦ÌM for NIH3T3 fibroblasts.	Not found	26053120	Biochemistry. 2015 Jun 30;54(25):3921-31. doi: 10.1021/acs.biochem.5b00392.	"Areum Shin, Eunjung Lee,  Dasom Jeon, Young-Guen Park, Jeong Kyu Bang, Yong-Sun Park, Song Yub Shin, and Yangmee Kim"	Peptoid-Substituted Hybrid Antimicrobial Peptide Derived from Papiliocin and Magainin 2 with Enhanced Bacterial Selectivity and Anti-inflammatory Activity
DRAMP21038	WGRRGWGPGRRYVRN	15	analog 1 (Derived from  Ib-AMP1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, beta turn"	" In sodium phosphate buffer, the CD spectra of Ib-AMP1 and all linear analogs showed a large absorbance in the region of 190-200 nm, indicating a random coil structure. The spectra of Ib-AMP1 and analogs 1, 2, 3, and 4 became significantly more b-turn in 30 mM SDS micelles"	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19778562] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=8 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus(KCTC 1621)(MIC=4 ¦ÌM), Staphylococcus aureus (MRSA)(CCARM 3543)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=16 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=4 ¦ÌM), Pseudomonas aeruginosa (MDRPA)(CCARM 2095)(MIC=16 ¦ÌM) "	[Ref.19778562] MHC>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.19778562] No cytotoxicity information found.	Not found	19778562	Peptides. 2009 Dec;30(12):2144-9. doi: 10.1016/j.peptides.2009.09.020.	"Peng Wang  , Jeong-Kyu Bang  , Hak Jun Kim  , Jin-Kyoung Kim  , Yangmee Kim , Song Yub Shin"	Antimicrobial specificity and mechanism of action of disulfide-removed linear analogs of the plant-derived Cys-rich antimicrobial peptide Ib-AMP1
DRAMP21039	WGRRGWGpGRRYVRN	15	analog 2 (Derived from  Ib-AMP2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, beta turn"	" In sodium phosphate buffer, the CD spectra of Ib-AMP1 and all linear analogs showed a large absorbance in the region of 190-200 nm, indicating a random coil structure. The spectra of Ib-AMP1 and analogs 1, 2, 3, and 4 became significantly more b-turn in 30 mM SDS micelles"	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.19778562] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4 	[Ref.19778562] MHC>400 	Linear	Free	Amidation	None	Mixed(D-Pro8)	[Ref.19778562] No cytotoxicity information found.	Not found	19778562	Peptides.?2009 Dec;30(12):2144-9. doi: 10.1016/j.peptides.2009.09.020.	"Peng Wang  , Jeong-Kyu Bang  , Hak Jun Kim  , Jin-Kyoung Kim  , Yangmee Kim , Song Yub Shin"	Antimicrobial specificity and mechanism of action of disulfide-removed linear analogs of the plant-derived Cys-rich antimicrobial peptide Ib-AMP1
DRAMP21040	WGRRGWGaGRRYVRW	15	analog 3 (Derived from  Ib-AMP2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, beta turn"	" In sodium phosphate buffer, the CD spectra of Ib-AMP1 and all linear analogs showed a large absorbance in the region of 190¨C200 nm, indicating a random coil structure. The spectra of Ib-AMP1 and analogs 1, 2, 3, and 4 became significantly more b-turn in 30 mM SDS micelles"	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19778562] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus(KCTC 1621)(MIC=4 ¦ÌM), Staphylococcus aureus (MRSA)(CCARM 3543)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=16 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=4 ¦ÌM), Pseudomonas aeruginosa (MDRPA)(CCARM 2095)(MIC=16 ¦ÌM) "	[Ref.19778562] MHC>400 [Ref.19778562] MHC>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	The 'a' in sequence is Ala peptoid residue (Nala) (CH3¨CNH¨CCH2¨CCOOH)	L	[Ref.19778562] No cytotoxicity information found.	Not found	19778562	Peptides. 2009 Dec;30(12):2144-9. doi: 10.1016/j.peptides.2009.09.020.	"Peng Wang  , Jeong-Kyu Bang  , Hak Jun Kim  , Jin-Kyoung Kim  , Yangmee Kim , Song Yub Shin"	Antimicrobial specificity and mechanism of action of disulfide-removed linear analogs of the plant-derived Cys-rich antimicrobial peptide Ib-AMP1
DRAMP21041	WGRRGWGkGRRYVRW	15	analog 4 (Derived from  Ib-AMP2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, beta turn"	" In sodium phosphate buffer, the CD spectra of Ib-AMP1 and all linear analogs showed a large absorbance in the region of 190¨C200 nm, indicating a random coil structure. The spectra of Ib-AMP1 and analogs 1, 2, 3, and 4 became significantly more b-turn in 30 mM SDS micelles"	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19778562] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=8 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus(KCTC 1621)(MIC=4 ¦ÌM), Staphylococcus aureus (MRSA)(CCARM 3543)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=4 ¦ÌM), Pseudomonas aeruginosa (MDRPA)(CCARM 2095)(MIC=16 ¦ÌM)"	[Ref.19778562] MHC>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	The 'k' in sequence is Lys peptoid residue (Nlys) (NH2¨CCH2¨CCH2¨CCH2¨CCH2¨CNH¨CCH2¨CCOOH).	L	[Ref.19778562] No cytotoxicity information found.	Not found	19778562	Peptides. 2009 Dec;30(12):2144-9. doi: 10.1016/j.peptides.2009.09.020.	"Peng Wang  , Jeong-Kyu Bang  , Hak Jun Kim  , Jin-Kyoung Kim  , Yangmee Kim , Song Yub Shin"	Antimicrobial specificity and mechanism of action of disulfide-removed linear analogs of the plant-derived Cys-rich antimicrobial peptide Ib-AMP1
DRAMP21042	ILPWKWPWWKWRR	13	A2 (Derived from Indolicidin (IN))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=10 ¦Ìg/ml), Staphylococcus epidermidis(MIC=10 ¦Ìg/ml), Staphylococcus aureus(MIC=5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli(MIC=20 ¦Ìg/ml), Pseudomonas aeruginosa(MIC=20 ¦Ìg/ml), Salmonella typhimurium(MIC=10 ¦Ìg/ml)"	[Ref.19428758] HC50=490 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	L	[Ref.19428758] No cytotoxicity information found.	Not found	19428758	Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.	"Yong Hai Nan , Jeong-Kyu Bang , Song Yub Shin"	Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity
DRAMP21043	ILKWKWPWWPWRR	13	A3 (Derived from Indolicidin (IN))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=5 ¦Ìg/ml), Staphylococcus epidermidis(MIC=10 ¦Ìg/ml), Staphylococcus aureus(MIC=5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli(MIC=10 ¦Ìg/ml), Pseudomonas aeruginosa(MIC=20 ¦Ìg/ml), Salmonella typhimurium(MIC=10 ¦Ìg/ml)"	[Ref.19428758] HC50=400 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	L	[Ref.19428758] No cytotoxicity information found.	Not found	19428758	Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.	"Yong Hai Nan , Jeong-Kyu Bang , Song Yub Shin"	Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity
DRAMP21044	ILKWKWKWWPWRR	13	A4 (Derived from Indolicidin (IN))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=10 ¦Ìg/ml), Staphylococcus epidermidis(MIC=10 ¦Ìg/ml), Staphylococcus aureus(MIC=10 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli(MIC=10 ¦Ìg/ml), Pseudomonas aeruginosa(MIC=10 ¦Ìg/ml), Salmonella typhimurium(MIC=10 ¦Ìg/ml)"	[Ref.19428758] HC50=560 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	L	[Ref.19428758] No cytotoxicity information found.	Not found	19428758	Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.	"Yong Hai Nan , Jeong-Kyu Bang , Song Yub Shin"	Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity
DRAMP21045	ILPWKWKWWKWRR	13	A5 (Derived from Indolicidin (IN))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=5 ¦Ìg/ml), Staphylococcus epidermidis(MIC=10 ¦Ìg/ml), Staphylococcus aureus(MIC=5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli(MIC=10 ¦Ìg/ml), Pseudomonas aeruginosa(MIC=10 ¦Ìg/ml), Salmonella typhimurium(MIC=10 ¦Ìg/ml)"	[Ref.19428758] HC50>800 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	L	[Ref.19428758] No cytotoxicity information found.	Not found	19428758	Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.	"Yong Hai Nan , Jeong-Kyu Bang , Song Yub Shin"	Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity
DRAMP21046	ILKWKWPWWKWRR	13	A6 (Derived from Indolicidin (IN))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=5 ¦Ìg/ml), Staphylococcus epidermidis(MIC=10 ¦Ìg/ml), Staphylococcus aureus(MIC=5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli(MIC=10 ¦Ìg/ml), Pseudomonas aeruginosa(MIC=10 ¦Ìg/ml), Salmonella typhimurium(MIC=10 ¦Ìg/ml)"	[Ref.19428758] HC50>800 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	L	[Ref.19428758] No cytotoxicity information found.	Not found	19428758	Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.	"Yong Hai Nan , Jeong-Kyu Bang , Song Yub Shin"	Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity
DRAMP21047	ILKWKWKWWKWRR	13	A7 (Derived from Indolicidin (IN))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.19428758] Gram-positive bacteria : Bacillus subtilis(MIC=5 ¦Ìg/ml), Staphylococcus epidermidis(MIC=10 ¦Ìg/ml), Staphylococcus aureus(MIC=5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli(MIC=10 ¦Ìg/ml), Pseudomonas aeruginosa(MIC=10 ¦Ìg/ml), Salmonella typhimurium(MIC=5 ¦Ìg/ml)"	[Ref.19428758] HC50>800 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	L	[Ref.19428758] No cytotoxicity information found.	Not found	19428758	Peptides. 2009 May;30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.	"Yong Hai Nan , Jeong-Kyu Bang , Song Yub Shin"	Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity
DRAMP21048	GLLWKWGWKWKEFLRIVGY	19	peptide 6 (Derived from seq2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.28236791] Gram-positive bacteria : Staphylococcus aureus(MIC>1024 ¦Ìg/ml);##Gram-negative bacteria : Pseudomonas aeruginosa(MIC>1024 ¦Ìg/ml)	[Ref.28236791] 51.36% hemolysis at 128 ¦Ìg/ml	Linear	Free	Amidation	None	L	[Ref.28236791] No cytotoxicity information found.	Not found	28236791	Colloids Surf B Biointerfaces. 2017 May 1;153:152-159. doi: 10.1016/j.colsurfb.2017.02.003.	"P. Maturanaa, M. Martinez , M.E. Noguerac, N.C. Santos , E.A. Disalvoa, L. Semorile , P.C. Maffia , A. Hollmann"	Lipid selectivity in novel antimicrobial peptides: Implication on antimicrobial and hemolytic activity
DRAMP21049	GLLRKWGKKWKEFLRRVWK	19	peptide 6.2 (Derived from seq2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	The spectra obtained confirmed an alpha-helix conversion in the presence of negatively charged micelles.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.28236791] Gram-positive bacteria : Staphylococcus aureus(MIC=32 ¦Ìg/ml);##Gram-negative bacteria : Pseudomonas aeruginosa(MIC=32 ¦Ìg/ml)	[Ref.28236791] 34.46% hemolysis at 128 ¦Ìg/ml	Linear	Free	Amidation	None	L	[Ref.28236791] No cytotoxicity information found.	Not found	28236791	Colloids Surf B Biointerfaces. 2017 May 1;153:152-159. doi: 10.1016/j.colsurfb.2017.02.003.	"P. Maturanaa, M. Martinez , M.E. Noguerac, N.C. Santos , E.A. Disalvoa, L. Semorile , P.C. Maffia , A. Hollmann"	Lipid selectivity in novel antimicrobial peptides: Implication on antimicrobial and hemolytic activity
DRAMP21050	AWCFRVCYRGICYRRCR	17	TP1[K1A] (Derived from TP1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.03 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=0.5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.03 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.06 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=2 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.125 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.125 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=0.5 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.25 ¦Ìg/ml)"	[Ref.28960954] MHC10=2.1 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1
DRAMP21051	KACFRVCYRGICYRRCR	17	TP1[W2A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.5 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=4 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 ¦Ìg/ml)"	[Ref.28960954] MHC10=8 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-2
DRAMP21052	KWAFRVCYRGICYRRSR	17	"TP1[C3A, C16S] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.5 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC>16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=4 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=16 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=16 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC>16 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC>16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=4 ¦Ìg/ml)"	[Ref.28960954] MHC10=8 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	Disulfide bond between Cys7 and Cys12.	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-3
DRAMP21053	KWCARVCYRGICYRRCR	17	TP1[F4A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=2 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 ¦Ìg/ml)"	[Ref.28960954] MHC10=40 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-4
DRAMP21054	KWCFAVCYRGICYRRCR	17	TP1[R5A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.03 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=0.5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=8 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.06 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.125 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=0.5 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=4 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.25 ¦Ìg/ml)"	[Ref.28960954] MHC10=2 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-5
DRAMP21055	KWCFRACYRGICYRRCR	17	TP1[V6A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=2 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=1 ¦Ìg/ml)"	[Ref.28960954] MHC10=1.2 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-6
DRAMP21056	KWCFRVAYRGISYRRCR	17	"TP1[C7A, C12S] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 [Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=2 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=4 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=4 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 ¦Ìg/ml)"	[Ref.28960954] MHC10=1 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	Disulfide bond between Cys3 and Cys16.	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis.2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-7
DRAMP21057	KWCFRVCARGICYRRCR	17	TP1[Y8A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.06 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=8 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=0.125 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC= ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 ¦Ìg/ml)"	[Ref.28960954] MHC10=8 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bond between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-8
DRAMP21058	KWCFRVCYAGICYRRCR	17	TP1[R9A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=1 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.03 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=2 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.06 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.125 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=1 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=2 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.25 ¦Ìg/ml)"	[Ref.28960954] MHC10=2 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-9
DRAMP21059	KWCFRVCYRAICYRRCR	17	TP1[G10A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.03 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=0.5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.06 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.03 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=4 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.6 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.6 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=0.5 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=2 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.06 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.5 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-10
DRAMP21060	KWCFRVCYRGACYRRCR	17	TP1[I11A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=2 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=8 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=1 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=2 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 ¦Ìg/ml)"	[Ref.28960954] MHC10=32 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation (Arg17)	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-11
DRAMP21061	KWCFRVSYRGIAYRRCR	17	"TP1[C7S, C12A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=4 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=16 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=8 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=2 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.6 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	Disulfide bond between Cys3 and Cys16.	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-12
DRAMP21062	KWCFRVCYRGICARRCR	17	TP1[Y13A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.06 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=8 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.125 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=2 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=4 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 ¦Ìg/ml)"	[Ref.28960954] MHC10=1 [Ref.28960954] MHC10=1 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bond between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-13
DRAMP21063	KWCFRVCYRGICYARCR	17	TP1[R14A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=0.5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.06 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=1 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.125 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.125 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.125 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=0.25 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.25 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.5 [Ref.28960954] MHC10=0.5 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-14
DRAMP21064	KWCFRVCYRGICYRACR	17	TP1[R15A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.03 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=4 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=2 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.25 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.45 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-15
DRAMP21065	KWSFRVCYRGICYRRAR	17	"TP1[C3S, C16A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=4 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=4 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.25 ¦Ìg/ml)"	[Ref.28960954] MHC10=3 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	Disulfide bond between Cys7 and Cys12.	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-16
DRAMP21066	KWCFRVCYRGICYRRCA	17	TP1[R17A] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.015 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=0.5 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.015 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=4 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.125 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.125 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=0.5 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=4 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.25 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.45 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-17
DRAMP21067	KWAFRVCYRGICYRRAR	17	"TP1[C3A, C16A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=8 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=1 ¦Ìg/ml)"	[Ref.28960954] MHC10=40 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	Disulfide bond between Cys7 and Cys12.	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-18
DRAMP21068	KWCFRVAYRGIAYRRCR	17	"TP1[C7A, C12A] (Derived from TP1)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=2 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=2 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=1 ¦Ìg/ml)"	[Ref.28960954] MHC10=8 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	Disulfide bond between Cys3 and Cys16.	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-19
DRAMP21069	KWAFRVAYRGIAYRRAR	17	"TP1[C3A, C7A, C12A, C16A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=1 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=8 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=16 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=16 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=16 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=4 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC>16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=1 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.24 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-20
DRAMP21070	KWCFRRCYAGICYRRCR	17	"TP1[V6R, R9A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC>16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=16 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=16 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC>16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=4 ¦Ìg/ml)"	[Ref.28960954] MHC10=11 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-21
DRAMP21071	RWCFRVCYRGICYRRCR	17	TP1[K1R] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=1 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=4 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.125 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=0.5 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=4 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.25 ¦Ìg/ml)"	[Ref.28960954] MHC10=1 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-22
DRAMP21072	KWCGRVCYRGICYRRCR	17	TP1[F4G] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.5 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=2 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.47 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-23
DRAMP21073	KWCSRVCYRGICYRRCR	17	TP1[F4S] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.5 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=4 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=4 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC>16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=4 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.23 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-24
DRAMP21074	KWCFRVCGRGICYRRCR	17	TP1[Y8G] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.5 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=8 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=8 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=2 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=4 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC>16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=4 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.4 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-25
DRAMP21075	KWCFRVCYRGGCYRRCR	17	TP1[I11G] (Derived from TP1) 	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 [Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=8 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=4 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=1 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.2 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12."	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-26
DRAMP21076	KWCARVCARGACYRRCR	17	"TP1[F4A, Y8A, I11A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC>16 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC>16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=8 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC>16 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC>16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC>16 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.9 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis.2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-27
DRAMP21077	KWCFVCYRGICYRRCG	16	"TP1[-R5, R17G] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=1 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC>16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=8 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC>16 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=16 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC>16 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC>16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=4 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.3 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis.2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-28
DRAMP21078	AWCARVCYRGICYRRCR	17	"TP1[K1A, F4A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=16 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC>16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=2 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=4 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=4 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=4 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC>16 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=2 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=8 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC>16 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC>16 ¦Ìg/ml)"	[Ref.28960954] MHC10=32 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-29
DRAMP21079	AWCFRVCARGICYRRCR	17	"TP1[K1A, Y8A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.5 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=8 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=1 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=8 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=1 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=4 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=2 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.4 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-30
DRAMP21080	AWCFRVCYRGACYRRCR	17	"TP1[K1A, I11A] (Derived from TP1) "	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.125 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.125 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.25 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=4 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.25 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=2 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC>16 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=1 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.2 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-31
DRAMP21081	KWCFRVCYAGICYRRCA	17	"TP1[R9A, R17A] (Derived from TP1)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans"	"[Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.06 ¦Ìg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=2 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.03 ¦Ìg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.06 ¦Ìg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.5 ¦Ìg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=4 ¦Ìg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 ¦Ìg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.5 ¦Ìg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=2 ¦Ìg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 ¦Ìg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 ¦Ìg/ml)"	[Ref.28960954] MHC10=0.2 ¦Ìg/ml against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys7 and Cys12"	L	"[Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 ¦Ìg/ml."	Not found	28960954	ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.	"Ingrid A. Edwards , Alysha G. Elliott , Angela M. Kavanagh , Mark A. T. Blaskovich , and Matthew A. Cooper"	Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-32
DRAMP21082	KWCFCVCYRGICRCRCRG	18	ccTP 3 (Derived from TP2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Beta tile	Although there is insufficient information to deconvolute these CD spectra of these two-b-strand cyclic cystine-knot structures due to the various contributions by 	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida kefyr, Candida tropicalis"	"[Ref.10673369] Gram-positive bacteria : Staphylococcus aureus(MIC=1.3 ¦ÌM(low-salt);MIC=0.9 ¦ÌM(high-salt)), Micrococcus luteus(MIC=0.5 ¦ÌM(low-salt);MIC=0.5 ¦ÌM(high-salt)), Enterococcus faecalis(MIC=1.9 ¦ÌM(low-salt);MIC=1.3 ¦ÌM(high-salt));##Gram-negative bacteria : Escherichia coli(MIC=10.4 ¦ÌM(low-salt);MIC=0.9 ¦ÌM(high-salt)), Pseudomonas aeruginosa(MIC=6.2 ¦ÌM(low-salt);MIC=10.4 ¦ÌM(high-salt)), Primula vulgaris(MIC=16.4 ¦ÌM(low-salt);MIC=28.9 ¦ÌM(high-salt)), Klebsiella oxytoca(MIC=4.0 ¦ÌM(low-salt);MIC=7.6 ¦ÌM(high-salt));##Fungi : Candida albicans(MIC=24.2 ¦ÌM(low-salt);MIC=30.2 ¦ÌM(high-salt)), Candida kefyr(MIC=1.1 ¦ÌM(low-salt);MIC=4.3 ¦ÌM(high-salt)), Candida tropicalis(MIC=12.4 ¦ÌM(low-salt);MIC=3.9 ¦ÌM(high-salt))"	[Ref.10673369] EC25=590 ¦ÌM against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys5 and Cys14, Cys7 and Cys12."	L	[Ref.10673369] No cytotoxicity information found.	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"James P. Tam, Yi-An Lu, and Jin-Long Yang"	Marked Increase in Membranolytic Selectivity of Novel Cyclic Tachyplesins Constrained with an Antiparallel Two-b Strand Cystine Knot Framework
DRAMP21083	KWCRCVCRRGICRCFCRG	18	ccTP 5 (Derived from TP2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Beta tile	Although there is insufficient information to deconvolute these CD spectra of these two-b-strand cyclic cystine-knot structures due to the various contributions by 	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida kefyr, Candida tropicalis"	"[Ref.10673369] Gram-positive bacteria : Staphylococcus aureus(MIC=1.7 ¦ÌM(low-salt);MIC=1.3 ¦ÌM(high-salt)), Micrococcus luteus(MIC=0.5 ¦ÌM(low-salt);MIC=0.8 ¦ÌM(high-salt)), Enterococcus faecalis(MIC=0.7 ¦ÌM(low-salt);MIC=0.5 ¦ÌM(high-salt));##Gram-negative bacteria : Escherichia coli(MIC=5.5 ¦ÌM(low-salt);MIC=1.2 ¦ÌM(high-salt)), Pseudomonas aeruginosa(MIC=3.9 ¦ÌM(low-salt);MIC=4.7 ¦ÌM(high-salt)), Primula vulgaris(MIC=16.8 ¦ÌM(low-salt);MIC=55.6 ¦ÌM(high-salt)), Klebsiella oxytoca(MIC=2.4 ¦ÌM(low-salt);MIC=5.4 ¦ÌM(high-salt));##Fungi : Candida albicans(MIC=7.1 ¦ÌM(low-salt);MIC=5.1 ¦ÌM(high-salt)), Candida kefyr(MIC=4.2 ¦ÌM(low-salt);MIC=0.7 ¦ÌM(high-salt)), Candida tropicalis(MIC=1.9 ¦ÌM(low-salt);MIC=4.8 ¦ÌM(high-salt))"	[Ref.10673369] EC25=920 ¦ÌM against human red blood cells	Cyclic	Free	Amidation	"Disulfide bonds between Cys3 and Cys16, Cys5 and Cys14, Cys7 and Cys12."	L	[Ref.10673369] No cytotoxicity information found.	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"James P. Tam, Yi-An Lu, and Jin-Long Yang"	Marked Increase in Membranolytic Selectivity of Novel Cyclic Tachyplesins Constrained with an Antiparallel Two-b Strand Cystine Knot Framework
DRAMP21084	GWCRCVCRRGICRCFCRK	18	ccTP 6 (Derived from TP2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Beta tile	Although there is insufficient information to deconvolute these CD spectra of these two-b-strand cyclic cystine-knot structures due to the various contributions by 	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Candida kefyr, Candida tropicalis"	"[Ref.10673369] Gram-positive bacteria : Staphylococcus aureus(MIC=1.7 ¦ÌM(low-salt);MIC=0.7 ¦ÌM(high-salt)), Micrococcus luteus(MIC=0.3 ¦ÌM(low-salt);MIC=0.4 ¦ÌM(high-salt)), Enterococcus faecalis(MIC=1.4 ¦ÌM(low-salt);MIC=1.2 ¦ÌM(high-salt));##Gram-negative bacteria : Escherichia coli(MIC=6.1 ¦ÌM(low-salt);MIC=1.2 ¦ÌM(high-salt)), Pseudomonas aeruginosa(MIC=2.0 ¦ÌM(low-salt);MIC=4.7 ¦ÌM(high-salt)), Primula vulgaris(MIC=17.0 ¦ÌM(low-salt);MIC=39.8 ¦ÌM(high-salt)), Klebsiella oxytoca(MIC=4.1 ¦ÌM(low-salt);MIC=4.1 ¦ÌM(high-salt));##Fungi : Candida albicans(MIC=10.5 ¦ÌM(low-salt);MIC=5.2 ¦ÌM(high-salt)), Candida kefyr(MIC=1.1 ¦ÌM(low-salt);MIC=0.7 ¦ÌM(high-salt)), Candida tropicalis(MIC=2.3 ¦ÌM(low-salt);MIC=1.9 ¦ÌM(high-salt))"	[Ref.10673369] EC25=3900 ¦ÌM against human red blood cells	Cyclic	Free	Amidation (Gly18)	"Disulfide bonds between Cys3 and Cys16, Cys5 and Cys14, Cys7 and Cys12."	L	No cytotoxicity information found	Not found	10673369	Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.	"James P. Tam, Yi-An Lu, and Jin-Long Yang"	Marked Increase in Membranolytic Selectivity of Novel Cyclic Tachyplesins Constrained with an Antiparallel Two-b Strand Cystine Knot Framework
DRAMP21085	RFRRLRWKTRWRLKKI	16	PRW4 (PR) (Derived from PMAP-36)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix, beta Sheet"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25818457] Gram-positive bacteria : Staphylococcus aureus 25923(MIC=73.6 mg/L), Staphylococcus aureus 29213(MIC=9.2 mg/L), Staphylococcus epidermidis 12228(MIC=18.4 mg/L), Enterococcus faecalis 29212(MIC=9.2 mg/L), Bacillus subtilis 11060(MIC=18.4 mg/L);##Gram-negative bacteria : Escherichia coli 078(MIC=9.2 mg/L), Escherichia coli K88(MIC=9.2 mg/L), Escherichia coli ER2566(MIC=18.4 mg/L), Escherichia coli 44102(MIC=18.4 mg/L), Escherichia coli 1515(MIC=9.2 mg/L), Escherichia coli 25922(MIC=9.2 mg/L), Escherichia coli UB1005(MIC=9.2 mg/L), Salmonella typhimurium 7731(MIC=18.4 mg/L), Salmonella typhimurium 1402(MIC=18.4 mg/L), Pseudomonas aeruginosa 21625(MIC=73.6 mg/L), Pseudomonas aeruginosa 21630(MIC=36.8 mg/L), Pseudomonas aeruginosa 10419(MIC=36.8 mg/L), Pseudomonas aeruginosa 27853(MIC>294.3 mg/L), Salmonella pullorum 7913(MIC>294.3 mg/L)"	[Ref.25818457] 0 % hemolysis at 294.3 mg/L against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.25818457] The cell viability of PRW4 is 100%, 96%, 92%, 86%, 85%, 83%, 82%, 80% and 80% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 ¦Ìg/ml"	Not found	25818457	Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.	"Zhi Ma, Dandan Wei, Ping Yan, Xin Zhu, Anshan Shan , Zhongpeng Bi"	"Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of a-helix-based peptide amphiphiles"
DRAMP21086	RFRRLRWKTRWRLKKIRFGRFLRKIRRFRPK	31	PR-FO (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix, beta Sheet"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25818457] Gram-positive bacteria : Staphylococcus aureus 25923(MIC=8.6 mg/L), Staphylococcus aureus 29213(MIC=4.3 mg/L), Staphylococcus epidermidis 12228(MIC=2.2 mg/L), Enterococcus faecalis 29212(MIC=1.1 mg/L), Bacillus subtilis 11060(MIC=2.2 mg/L);##Gram-negative bacteria : Escherichia coli 078(MIC=2.2 mg/L), Escherichia coli K88(MIC=4.3 mg/L), Escherichia coli ER2566(MIC=2.2 mg/L), Escherichia coli 44102(MIC=8.6 mg/L), Escherichia coli 1515(MIC=2.2 mg/L), Escherichia coli 25922(MIC=2.2 mg/L), Escherichia coli UB1005(MIC=4.3 mg/L), Salmonella typhimurium 7731(MIC=0.5 mg/L), Salmonella typhimurium 1402(MIC=8.6 mg/L), Pseudomonas aeruginosa 21625(MIC=8.6 mg/L), Pseudomonas aeruginosa 21630(MIC=0.5 mg/L), Pseudomonas aeruginosa 10419(MIC=4.3 mg/L), Pseudomonas aeruginosa 27853(MIC=8.6 mg/L), Salmonella pullorum 7913(MIC=8.6 mg/L)"	"[Ref.25818457] 0% hemolysis at 9.2 mg/L , 1% hemolysis at 18.4 mg/L , 4% hemolysis at 36.8mg/L  , 5% hemolysis at 73.6 mg/L , 10% hemolysis at 147.1 mg/L , 13% hemolysis at 294.3 mg/L against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.25818457] The cell viability of PR-FO is 93%, 89%, 84%, 79%, 74%, 69%, 67%, 64% and 62% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 ¦Ìg/ml."	Not found	25818457	Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.	"Zhi Ma, Dandan Wei, Ping Yan, Xin Zhu, Anshan Shan , Zhongpeng Bi"	"Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of a-helix-based peptide amphiphiles"
DRAMP21087	RFRRLRWKTRWRLKKICYCRRRFCVCV	27	PR-PG (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix, beta Sheet"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25818457] Gram-positive bacteria : Staphylococcus aureus 25923(MIC=29.6 mg/L), Staphylococcus aureus 29213(MIC=7.4 mg/L), Staphylococcus epidermidis 12228(MIC=7.4 mg/L), Enterococcus faecalis 29212(MIC=3.7 mg/L), Bacillus subtilis 11060(MIC=7.4 mg/L);##Gram-negative bacteria : Escherichia coli 078(MIC=14.8 mg/L), Escherichia coli K88(MIC=1.9 mg/L), Escherichia coli ER2566(MIC=3.7 mg/L), Escherichia coli 44102(MIC=1.9 mg/L), Escherichia coli 1515(MIC=14.8 mg/L), Escherichia coli 25922(MIC=3.7 mg/L), Escherichia coli UB1005(MIC=7.4 mg/L), Salmonella typhimurium 7731(MIC=14.8 mg/L), Salmonella typhimurium 1402(MIC=7.4 mg/L), Pseudomonas aeruginosa 21625(MIC=14.8 mg/L), Pseudomonas aeruginosa 21630(MIC=7.4 mg/L), Pseudomonas aeruginosa 10419(MIC=14.8 mg/L), Pseudomonas aeruginosa 27853(MIC=14.8 mg/L), Salmonella pullorum 7913(MIC=14.8 mg/L)"	"[Ref.25818457] 0.5% hemolysis at 1.1 mg/L , 2% hemolysis at 2.3 mg/L , 10% hemolysis at 4.6 mg/L , 23% hemolysis at 9.2 mg/L , 30% hemolysis at 18.4 mg/L , 45% hemolysis at 36.8mg/L  , 46% hemolysis at 73.6 mg/L , 47% hemolysis at 147.1 mg/L , 50% hemolysis at 294.3 mg/L against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.25818457] The cell viability of PR-FG is 92.7%, 76%, 64%, 58%, 53%, 43%, 39%, 37% and 34% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 ¦Ìg/ml."	Not found	25818457	Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.	"Zhi Ma, Dandan Wei, Ping Yan, Xin Zhu, Anshan Shan , Zhongpeng Bi"	"Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of a-helix-based peptide amphiphiles"
DRAMP21088	RFRRLRWKTRWRLKKIWWPFLRR	23	PR-TR (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix, beta Sheet"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25818457] Gram-positive bacteria : Staphylococcus aureus 25923(MIC=26.7 mg/L), Staphylococcus aureus 29213(MIC=6.7 mg/L), Staphylococcus epidermidis 12228(MIC=13.4 mg/L), Enterococcus faecalis 29212(MIC=3.3 mg/L), Bacillus subtilis 11060(MIC=3.3 mg/L);##Gram-negative bacteria : Escherichia coli 078(MIC=13.4 mg/L), Escherichia coli K88(MIC=1.7 mg/L), Escherichia coli ER2566(MIC=3.3 mg/L), Escherichia coli 44102(MIC=6.7 mg/L), Escherichia coli 1515(MIC=1.7 mg/L), Escherichia coli 25922(MIC=6.7 mg/L), Escherichia coli UB1005(MIC=3.3 mg/L), Salmonella typhimurium 7731(MIC=6.7 mg/L), Salmonella typhimurium 1402(MIC=13.4 mg/L), Pseudomonas aeruginosa 21625(MIC=6.7 mg/L), Pseudomonas aeruginosa 21630(MIC=13.4 mg/L), Pseudomonas aeruginosa 10419(MIC=6.7 mg/L), Pseudomonas aeruginosa 27853(MIC=13.4 mg/L), Salmonella pullorum 7913(MIC=13.4 mg/L)"	"[Ref.25818457] 0% hemolysis at 9.2 mg/L , 1% hemolysis at 18.4 mg/L , 4% hemolysis at 36.8mg/L  , 10% hemolysis at 73.6 mg/L , 17% hemolysis at 147.1 mg/L , 22% hemolysis at 294.3 mg/L against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.25818457] The cell viability of PR-TR is 94%, 89%, 83%, 77%, 74%, 71%, 68%, 66% and 60% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 ¦Ìg/ml"	Not found	25818457	Biomaterials. 2015 Jun;52:517-30. doi: 10.1016/j.biomaterials.2015.02.063.	"Zhi Ma, Dandan Wei, Ping Yan, Xin Zhu, Anshan Shan , Zhongpeng Bi"	"Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of a-helix-based peptide amphiphiles"
DRAMP21089	RFRRLRCKTRCRLKKI	16	C4 (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>128 ¦ÌM), Staphylococcus epidermidis 12228(MIC>128 ¦ÌM), Enterococcus faecalis 29212(MIC>128 ¦ÌM);##Gram-negative bacteria : Escherichia coli 25922(MIC=2 ¦ÌM), Escherichia coli 1005(MIC>128 ¦ÌM), Salmonella typhimurium 7731(MIC128 ¦ÌM)"	[Ref.25735802] MHC5>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 ¦ÌM.	Not found	25735802	Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.	"Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan"	Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ¦Á-helical propensity
DRAMP21090	RFRRLRDKTRDRLKKI	16	D4 (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>128 ¦ÌM), Staphylococcus epidermidis 12228(MIC>128 ¦ÌM), Enterococcus faecalis 29212(MIC>128 ¦ÌM);##Gram-negative bacteria : Escherichia coli 25922(MIC>128 ¦ÌM), Escherichia coli 1005(MIC>128 ¦ÌM), Salmonella typhimurium 7731(MIC>128 ¦ÌM)"	[Ref.25735802] MHC5>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 ¦ÌM.	Not found	25735802	Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.	"Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan"	Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ¦Á-helical propensity
DRAMP21091	RFRRLRIKTRIRLKKI	16	I4 (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=64 ¦ÌM), Staphylococcus epidermidis 12228(MIC=16 ¦ÌM), Enterococcus faecalis 29212(MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli 25922(MIC=8 ¦ÌM), Escherichia coli 1005(MIC=16 ¦ÌM), Salmonella typhimurium 7731(MIC=16 ¦ÌM)"	[Ref.25735802] MHC5>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 ¦ÌM.	Not found	25735802	Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.	"Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan"	Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ¦Á-helical propensity
DRAMP21092	RFRRLRPKTRPRLKKI	16	P4 (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>128 ¦ÌM), Staphylococcus epidermidis 12228(MIC>128 ¦ÌM), Enterococcus faecalis 29212(MIC>128 ¦ÌM);##Gram-negative bacteria : Escherichia coli 25922(MIC=32 ¦ÌM), Escherichia coli 1005(MIC=32 ¦ÌM), Salmonella typhimurium 7731(MIC=32 ¦ÌM)"	[Ref.25735802] MHC5>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 ¦ÌM.	Not found	25735802	Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.	"Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan"	Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ¦Á-helical propensity
DRAMP21093	RFRRLRwKTRwRLKKI	16	PRW4-d (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=8 ¦ÌM), Staphylococcus epidermidis 12228(MIC=16 ¦ÌM), Enterococcus faecalis 29212(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli 25922(MIC=4 ¦ÌM), Escherichia coli 1005(MIC=8 ¦ÌM), Salmonella typhimurium 7731(MIC=4 ¦ÌM)"	[Ref.25735802] MHC5>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	"Mixed(D-Trp7, D-Trp11)"	[Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 ¦ÌM.	Not found	25735802	Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.	"Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan"	Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ¦Á-helical propensity
DRAMP21094	RFRRLRWRTRWRLRRI	16	PRW4-R (Derived from PRW4)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25735802] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=4 ¦ÌM), Staphylococcus epidermidis 12228(MIC=4 ¦ÌM), Enterococcus faecalis 29212(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli 25922(MIC=4 ¦ÌM), Escherichia coli 1005(MIC=2 ¦ÌM), Salmonella typhimurium 7731(MIC=4 ¦ÌM)"	[Ref.25735802] MHC5>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25735802] The peptide exhibited no cytoxicity against HaCaT cells in the range of 0/25-256 ¦ÌM.	Not found	25735802	Acta Biomater. 2015 May;18:155-67. doi: 10.1016/j.actbio.2015.02.023.	"Xin Zhu, Licong Zhang, Jue Wang, Zhi Ma, Wei Xu, Jianping Li, Anshan Shan"	Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different ¦Á-helical propensity
DRAMP21095	IRCRRRFCRI	10	IR1 (Derived from PG-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=64 ¦ÌM), Staphylococcus epidermidis(MIC=64 ¦ÌM), Streptococcus faecalis(MIC=64 ¦ÌM), Bacillus subtilis(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=8 ¦ÌM), Salmonella pullorum(MIC=16 ¦ÌM), Salmonella typhimurium(MIC=128 ¦ÌM), Bacteriump yocyaneum(MIC=64 ¦ÌM)"	[Ref.24621994] MHC10>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.24621994] No cytotoxicity information found.	Not found	24621994	PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.	"Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang"	Antimicrobial potency and selectivity of simplified symmetric-end peptides
DRAMP21096	IRIRCRRRFCRIRI	14	IR2 (Derived from PG-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Beta sheet, beta hairpin"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=4 ¦ÌM), Staphylococcus epidermidis(MIC=4 ¦ÌM), Streptococcus faecalis(MIC=4 ¦ÌM), Bacillus subtilis(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=1 ¦ÌM), Salmonella pullorum(MIC=1 ¦ÌM), Salmonella typhimurium(MIC=4 ¦ÌM), Bacteriump yocyaneum(MIC=4 ¦ÌM)"	[Ref.24621994] MHC10=128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.24621994] No cytotoxicity information found.	Not found	24621994	PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.	"Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang"	Antimicrobial potency and selectivity of simplified symmetric-end peptides
DRAMP21097	FRCRRRFCRF	10	FR1 (Derived from PG-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=32 ¦ÌM), Staphylococcus epidermidis(MIC=16 ¦ÌM), Streptococcus faecalis(MIC=32 ¦ÌM), Bacillus subtilis(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=4 ¦ÌM), Salmonella pullorum(MIC=16 ¦ÌM), Salmonella typhimurium(MIC=32 ¦ÌM), Bacteriump yocyaneum(MIC>128 ¦ÌM)"	[Ref.24621994] MHC10>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.24621994] No cytotoxicity information found.	Not found	24621994	PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.	"Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang"	Antimicrobial potency and selectivity of simplified symmetric-end peptides
DRAMP21098	FRFRCRRRFCRFRF	14	FR2 (Derived from PG-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=2 ¦ÌM), Staphylococcus epidermidis(MIC=2 ¦ÌM), Streptococcus faecalis(MIC=4 ¦ÌM), Bacillus subtilis(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=1 ¦ÌM), Salmonella pullorum(MIC=1 ¦ÌM), Salmonella typhimurium(MIC=2 ¦ÌM), Bacteriump yocyaneum(MIC=4 ¦ÌM)"	[Ref.24621994] MHC10=64 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.24621994] No cytotoxicity information found.	Not found	24621994	PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.	"Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang"	Antimicrobial potency and selectivity of simplified symmetric-end peptides
DRAMP21099	WRCRRRFCRW	10	WR1 (Derived from PG-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=8 ¦ÌM), Staphylococcus epidermidis(MIC=8 ¦ÌM), Streptococcus faecalis(MIC=8 ¦ÌM), Bacillus subtilis(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=2 ¦ÌM), Salmonella pullorum(MIC=4 ¦ÌM), Salmonella typhimurium(MIC=16 ¦ÌM), Bacteriump yocyaneum(MIC>128 ¦ÌM)"	[Ref.24621994] MHC10>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.24621994] No cytotoxicity information found.	Not found	24621994	PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.	"Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang"	Antimicrobial potency and selectivity of simplified symmetric-end peptides
DRAMP21100	WRWRCRRRFCRWRW	14	WR2 (Derived from PG-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC=4 ¦ÌM), Staphylococcus epidermidis(MIC=2 ¦ÌM), Streptococcus faecalis(MIC=2 ¦ÌM), Bacillus subtilis(MIC=1 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=4 ¦ÌM), Salmonella pullorum(MIC=2 ¦ÌM), Salmonella typhimurium(MIC=4 ¦ÌM), Bacteriump yocyaneum(MIC=8 ¦ÌM)"	[Ref.24621994] MHC10=64 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.24621994] No cytotoxicity information found.	Not found	24621994	PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.	"Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang"	Antimicrobial potency and selectivity of simplified symmetric-end peptides
DRAMP21101	PRCRRRFCRP	10	PR1 (Derived from PG-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC>128 ¦ÌM), Staphylococcus epidermidis(MIC>128 ¦ÌM), Streptococcus faecalis(MIC>128 ¦ÌM), Bacillus subtilis(MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=16 ¦ÌM), Salmonella pullorum(MIC>128 ¦ÌM), Salmonella typhimurium(MIC>128 ¦ÌM), Bacteriump yocyaneum(MIC>128 ¦ÌM)"	[Ref.24621994] MHC10>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.24621994] No cytotoxicity information found.	Not found	24621994	PLoS One.2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.	"Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang"	Antimicrobial potency and selectivity of simplified symmetric-end peptides
DRAMP21102	PRPRCRRRFCRPRP	14	PR2 (Derived from PG-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC>128 [Ref.24621994] Gram-positive bacteria : Staphylococcus aureus(MIC>128 ¦ÌM), Staphylococcus epidermidis(MIC>128 ¦ÌM), Streptococcus faecalis(MIC>128 ¦ÌM), Bacillus subtilis(MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=16 ¦ÌM), Salmonella pullorum(MIC>128 ¦ÌM), Salmonella typhimurium(MIC>128 ¦ÌM), Bacteriump yocyaneum(MIC>128 ¦ÌM)"	[Ref.24621994] MHC10>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.24621994] No cytotoxicity information found.	Not found	24621994	PLoS One. 2014 Mar 12;9(3):e91007. doi: 10.1371/journal.pone.0091007.	"Na Dong , Xin Zhu , Shuli Chou , Anshan Shan , Weizhong Li , Junguang Jiang"	Antimicrobial potency and selectivity of simplified symmetric-end peptides
DRAMP21165	GIMSSLMKKLKKIIKK	16	HYL-11 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=54 ¦ÌM), Staphylococcus epidermidis(MIC=1.7 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=22 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=7.1 ¦ÌM);##Fungi : Candida albicans(MIC=6.3 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21166	GILSSLLKKLKKIIAK	16	HYL-12 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=16 ¦ÌM), Staphylococcus epidermidis(MIC=1.8 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=8 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=5 ¦ÌM);##Fungi : Candida albicans(MIC=10 ¦ÌM)"	[Ref.26998557] LC50=284 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21164	GIMSSLMKKLAKIIKK	16	HYL-10 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=33 ¦ÌM), Staphylococcus epidermidis(MIC=2.9 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=15 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=5.2 ¦ÌM);##Fungi : Candida albicans(MIC=7.6 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21158	GIMSSLMKKLKKHIAK	16	HYL-4 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC>100 ¦ÌM), Staphylococcus epidermidis(MIC=10 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=26 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=6.4 ¦ÌM);##Fungi : Candida albicans(MIC=12 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21159	GIMISLMKKLAAHIAK	16	HYL-5 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=43 ¦ÌM), Staphylococcus epidermidis(MIC=8.8 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=12 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=47 ¦ÌM);##Fungi : Candida albicans(MIC=12 ¦ÌM)"	[Ref.26998557] LC50=320 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21160	GIMSSLMKKLAAIIAK	16	HYL-6 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=7.2 ¦ÌM), Staphylococcus epidermidis(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=3.6 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=8 ¦ÌM);##Fungi : Candida albicans(MIC=8.4 ¦ÌM)"	[Ref.26998557] LC50=93 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21161	GIMSSLMKKLAKIIAK	16	HYL-7 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=9 ¦ÌM), Staphylococcus epidermidis(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=3.7 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=4.5 ¦ÌM);##Fungi : Candida albicans(MIC=11 ¦ÌM)"	[Ref.26998557] LC50=88 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21162	GIMSSLMKKLKKIIAK	16	HYL-8 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=32 ¦ÌM), Staphylococcus epidermidis(MIC=1.9 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=9 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=5 ¦ÌM);##Fungi : Candida albicans(MIC=5.2 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21163	gimsslmkklkkiiak	16	HYL-9 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=13 ¦ÌM), Staphylococcus epidermidis(MIC=2.2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=6.3 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=3.2 ¦ÌM);##Fungi : Candida albicans(MIC=8 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	D	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21157	GIMSSLMKKLAAHIKK	16	HYL-3 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=85 ¦ÌM), Staphylococcus epidermidis(MIC=11 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=20 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=23 ¦ÌM);##Fungi : Candida albicans(MIC=5 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21156	GIMSSLMKKLAKHIAK	16	HYL-2 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=63 ¦ÌM), Staphylococcus epidermidis(MIC=6.2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=15 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=7.9 ¦ÌM);##Fungi : Candida albicans(MIC=14 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21155	GIMSSLMKKLKAHIAK	16	HYL-1 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC>100 ¦ÌM), Staphylococcus epidermidis(MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=30 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=26 ¦ÌM);##Fungi : Candida albicans(MIC=23 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21154	GIMSSLMKKLAAHIAK	16	"HYL (Bee, Insecta, Animals)"	No entry found	Not found	Not found	Solitary wild bee Hylaeus signatus	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=63 ¦ÌM), Staphylococcus epidermidis(MIC=13 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=15 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=20 ¦ÌM);##Fungi : Candida albicans(MIC=18 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21153	KRIRKRIKKWKR	12	KR-12-a8 (Derived from KR-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	"The CD spectra for all the peptides in 10 mM sodium phosphate buffer (pH 7.2) displayed a negative band at approximately 200 nm, indicating that the structure is random. In presence of 0.1% LPS, all the peptides showed characteristic ¦Á-helical CD spectra with two dichroic minimal values at 208 and 222 nm and a positive band near 192 nm .Among these peptides, KR-12-a8 had shown the least ¦Á-helical structure."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=2 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=2 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.24105706] HC50>800 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.24105706] The cell viability of RAW264.7 macrophage cells is 91.2%, 112.8%, 104.1%, 114.4%, 104.4%, 109.4%, 107.2% and 82.2% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	24105706	J Pept Sci.?2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.	"Jacob B, Park IS, Bang JK, Shin SY"	Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
DRAMP21151	LRIVKLILKWLR	12	KR-12-a6 (Derived from KR-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	"The CD spectra for all the peptides in 10 mM sodium phosphate buffer (pH 7.2) displayed a negative band at approximately 200 nm, indicating that the structure is random. In presence of 0.1% LPS, all the peptides showed characteristic ¦Á-helical CD spectra with two dichroic minimal values at 208 and 222 nm and a positive band near 192 nm ."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=8 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=2 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=16 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.24105706] HC50=22 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.24105706] The cell viability of RAW264.7 macrophage cells is 100%, 99.1%, 100%, 98.8%, 99.9%, 85.3%, 5.9% and 0% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	24105706	J Pept Sci.?2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.	"Jacob B, Park IS, Bang JK, Shin SY"	Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
DRAMP21150	KRIVKLILKWLR	12	KR-12-a5 (Derived from KR-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	"The CD spectra for all the peptides in 10 mM sodium phosphate buffer (pH 7.2) displayed a negative band at approximately 200 nm, indicating that the structure is random. In presence of 0.1% LPS, all the peptides showed characteristic ¦Á-helical CD spectra with two dichroic minimal values at 208 and 222 nm and a positive band near 192 nm ."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.24105706] HC50=96 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.24105706] The cell viability of RAW264.7 macrophage cells is 96.6%, 100.1%, 96.6%, 96.8%, 81.2%, 3.1%, 0% and 0% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	24105706	J Pept Sci.?2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.	"Jacob B, Park IS, Bang JK, Shin SY"	Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
DRAMP21152	KRIRKRIKKWLR	12	KR-12-a7 (Derived from KR-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	"The CD spectra for all the peptides in 10 mM sodium phosphate buffer (pH 7.2) displayed a negative band at approximately 200 nm, indicating that the structure is random. In presence of 0.1% LPS, all the peptides showed characteristic ¦Á-helical CD spectra with two dichroic minimal values at 208 and 222 nm and a positive band near 192 nm ."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=4 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.24105706] HC50>800 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.24105706] The cell viability of RAW264.7 macrophage cells is 92.5%, 100.9%, 97.2%, 96.6%, 92.5%, 101.2%, 90.6% and 81.9% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	24105706	J Pept Sci.?2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.	"Jacob B, Park IS, Bang JK, Shin SY"	Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
DRAMP21149	KRIVKLIKKWLR	12	KR-12-a4 (Derived from KR-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	"The CD spectra for all the peptides in 10 mM sodium phosphate buffer (pH 7.2) displayed a negative band at approximately 200 nm, indicating that the structure is random. In presence of 0.1% LPS, all the peptides showed characteristic ¦Á-helical CD spectra with two dichroic minimal values at 208 and 222 nm and a positive band near 192 nm ."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=8 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=4 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=1 ¦ÌM)"	[Ref.24105706] HC50>800 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.24105706] The cell viability of RAW264.7 macrophage cells is 101.9%, 99.9%, 96.6%, 95.6%, 95.3%, 80.9%, 17.8% and 0% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	24105706	J Pept Sci.?2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.	"Jacob B, Park IS, Bang JK, Shin SY"	Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
DRAMP21146	KRIVQRIKDWLR	12	KR-12-a1 (Derived from KR-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	"The CD spectra for all the peptides in 10 mM sodium phosphate buffer (pH 7.2) displayed a negative band at approximately 200 nm, indicating that the structure is random. In presence of 0.1% LPS, all the peptides showed characteristic ¦Á-helical CD spectra with two dichroic minimal values at 208 and 222 nm and a positive band near 192 nm ."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.24105706] HC50>800 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.24105706] The cell viability of RAW264.7 macrophage cells is 108.7%, 111.2%, 107.5%, 107.5%, 103.1%, 111.2%, 107.2%, 98.1% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	24105706	J Pept Sci.?2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.	"Jacob B, Park IS, Bang JK, Shin SY"	Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
DRAMP21148	KRIVKRIKKWLR	12	KR-12-a3 (Derived from KR-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	"The CD spectra for all the peptides in 10 mM sodium phosphate buffer (pH 7.2) displayed a negative band at approximately 200 nm, indicating that the structure is random. In presence of 0.1% LPS, all the peptides showed characteristic ¦Á-helical CD spectra with two dichroic minimal values at 208 and 222 nm and a positive band near 192 nm ."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.24105706] HC50>800 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.24105706] The cell viability of RAW264.7 macrophage cells is 104.7%, 111.6%, 105.3%, 108.4%, 111.2%, 104.4%, 108.8% and 95.0% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	24105706	J Pept Sci.?2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.	"Jacob B, Park IS, Bang JK, Shin SY"	Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
DRAMP21147	KRIVQRIKKWLR	12	KR-12-a2 (Derived from KR-12)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	"The CD spectra for all the peptides in 10 mM sodium phosphate buffer (pH 7.2) displayed a negative band at approximately 200 nm, indicating that the structure is random. In presence of 0.1% LPS, all the peptides showed characteristic ¦Á-helical CD spectra with two dichroic minimal values at 208 and 222 nm and a positive band near 192 nm ."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.24105706] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=8 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=1 ¦ÌM)"	[Ref.24105706] HC50>800 ¦ÌM against human red blood cells	Linear	Free	Amidation 	None	L	"[Ref.24105706] The cell viability of RAW264.7 macrophage cells is 111.9%, 103.4%, 102.2%, 102.2%, 100%, 101.2%, 112.5% and 95.0% at peptide concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	24105706	J Pept Sci.?2013 Nov;19(11):700-7. doi: 10.1002/psc.2552.	"Jacob B, Park IS, Bang JK, Shin SY"	Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
DRAMP21145	RIRWILRYWRWS	12	Myxinidin3 (Derived from Myxinidin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Beta Sheet	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26450121] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=1 ¦ÌM), Staphylococcus aureus CCARM 3114(MIC=8 ¦ÌM), Staphylococcus aureus CCARM 3709(MIC=2 ¦ÌM), Listeria monocytogenes (KCTC 3710)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2 ¦ÌM), Escherichia coli CCARM 1229(MIC=1 ¦ÌM), Escherichia coli CCARM 1238(MIC=2 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM), Salmonella typhimurium CCARM 8009(MIC=4 ¦ÌM), Salmonella typhimurium CCARM 8013(MIC=4 ¦ÌM), Pseudomonas aeruginosa (ATCC 27853)(MIC=4 ¦ÌM), Pseudomonas aeruginosa 3592(MIC=8 ¦ÌM), Pseudomonas aeruginosa 5018(MIC=8 ¦ÌM)"	"[Ref.26450121] 27% hemolysis at 50 ¦ÌM , 45% hemolysis at 100 ¦ÌM , 63% hemolysis at 200 ¦ÌM , 59% hemolysis at 400 ¦ÌM against human red blood cells"	Linear	Free	Free	None	L	"[Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 ¦ÌM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of"	Not found	26450121	Amino Acids.?2016 Feb;48(2):505-22. doi: 10.1007/s00726-015-2104-0.	"Han HM, Gopal R, Park Y"	"Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties."
DRAMP21142	HKCAKIKWRGVHVKYCA	17	AMP2041 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix, beta sheet, beta turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.23893489] Gram-positive bacteria : Staphylococcus aureus(MBC=3.71 ¦Ìg/ml, 1.83 ¦ÌM), MRSA(MBC=2.25 ¦Ìg/ml, 1.11 ¦ÌM), Streptococcus agalactiae(MBC>100 ¦Ìg/ml, 55 ¦ÌM);##Gram-negative bacteria : Pseudomonas aeruginosa(MBC=4.35 ¦Ìg/ml, 2.14 ¦ÌM), Escherichia coli(MBC=1.79 ¦Ìg/ml, 0.88 ¦ÌM), Salmonella enteritidis(MBC=10.41 ¦Ìg/ml, 5.13 ¦ÌM), Stenotrophomonas maltophilia(MBC=7.00 ¦Ìg/ml, 3.45 ¦ÌM)"	"[Ref.23893489] <1% hemolysis at 1 ¦Ìg/ml , <1% hemolysis at 12.5 ¦Ìg/ml , 5.73% hemolysis at 100 ¦Ìg/ml , 6.4% hemolysis at 250 ¦Ìg/ml , 9.4% hemolysis at 500 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Free	None	L	[Ref.23893489] The cytotoxicity (vs control) of P2041 is 6% against HUVEC (endothelial) cells at a peptide concentration of 100 ¦Ìg/ml. ##The cytotoxicity (vs control) of P2041 is 3% agaisnt WI-38 (fibroblast) cells at a peptide concentration of 100 ¦Ìg/m	Not found	23893489	J Pept Sci.?2013 Sep;19(9):554-65. doi: 10.1002/psc.2532.	"Romani AA, Baroni MC, Taddei S, Ghidini F, Sansoni P, Cavirani S, Cabassi CS"	In vitro activity of novel in silico-developed antimicrobial peptides against a panel of bacterial pathogens.
DRAMP21141	KWCRKWQWRGVKFIKCV	17	AMP126 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix, beta sheet, beta turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.23893489] Gram-positive bacteria : Staphylococcus aureus(MBC=46.5 ¦Ìg/ml, 20.65 ¦ÌM), MRSA(MBC>100 ¦Ìg/ml, 55 ¦ÌM), Streptococcus agalactiae(MBC=2.81 ¦Ìg/ml, 1.24 ¦ÌM);##Gram-negative bacteria : Pseudomonas aeruginosa(MBC=0.40 ¦Ìg/ml, 0.17 ¦ÌM), Escherichia coli(MBC=2.22 ¦Ìg/ml, 0.98 ¦ÌM), Salmonella enteritidis(MBC=10.8 ¦Ìg/ml, 4.80 ¦ÌM), Stenotrophomonas maltophilia(MBC=16.6 ¦Ìg/ml, 7.37 ¦ÌM)"	"[Ref.23893489] <1% hemolysis at 1 ¦Ìg/ml , <1% hemolysis at 12.5 ¦Ìg/ml , 5.30% hemolysis at 100 ¦Ìg/ml , 6.9% hemolysis at 250 ¦Ìg/ml , 12.5% hemolysis at 500 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Free	None	L	[Ref.23893489] The cytotoxicity (vs control) of P126 is 5% against HUVEC (endothelial) cells at a peptide concentration of 100 ¦Ìg/ml. ##The cytotoxicity (vs control) of P126 is 6% agaisnt WI-38 (fibroblast) cells at a peptide concentration of 100 ¦Ìg/ml.	Not found	23893489	J Pept Sci.?2013 Sep;19(9):554-65. doi: 10.1002/psc.2532.	"Romani AA, Baroni MC, Taddei S, Ghidini F, Sansoni P, Cavirani S, Cabassi CS"	In vitro activity of novel in silico-developed antimicrobial peptides against a panel of bacterial pathogens.
DRAMP21144	KIKWILKYWKWS	12	Myxinidin2 (Derived from Myxinidin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26450121] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=0.25 ¦ÌM), Staphylococcus aureus CCARM 3114(MIC=16 ¦ÌM), Staphylococcus aureus CCARM 3709(MIC=2 ¦ÌM), Listeria monocytogenes (KCTC 3710)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=1 ¦ÌM), Escherichia coli CCARM 1229(MIC=2 ¦ÌM), Escherichia coli CCARM 1238(MIC=4 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM), Salmonella typhimurium CCARM 8009(MIC=8 ¦ÌM), Salmonella typhimurium CCARM 8013(MIC=16 ¦ÌM), Pseudomonas aeruginosa (ATCC 27853)(MIC=4 ¦ÌM), Pseudomonas aeruginosa 3592(MIC=8 ¦ÌM), Pseudomonas aeruginosa 5018(MIC=4 ¦ÌM)"	"[Ref.26450121] 10% hemolysis at 50 ¦ÌM , 28% hemolysis at 100 ¦ÌM , 30% hemolysis at 200 ¦ÌM , 50% hemolysis at 400 ¦ÌM against human red blood cells"	Linear	Free	Free	None	L	"[Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 ¦ÌM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of"	Not found	26450121	Amino Acids.?2016 Feb;48(2):505-22. doi: 10.1007/s00726-015-2104-0.	"Han HM, Gopal R, Park Y"	"Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties."
DRAMP21143	GIHHILKYGKPS	12	Myxinidin1 (Derived from Myxinidin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26450121] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC>32 ¦ÌM), Staphylococcus aureus CCARM 3114(MIC>32 ¦ÌM), Staphylococcus aureus CCARM 3709(MIC>32 ¦ÌM), Listeria monocytogenes (KCTC 3710)(MIC>32 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC>32 ¦ÌM), Escherichia coli CCARM 1229(MIC>32 ¦ÌM), Escherichia coli CCARM 1238(MIC>32 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC>32 ¦ÌM), Salmonella typhimurium CCARM 8009(MIC>32 ¦ÌM), Salmonella typhimurium CCARM 8013(MIC>32 ¦ÌM), Pseudomonas aeruginosa (ATCC 27853)(MIC>32 ¦ÌM), Pseudomonas aeruginosa 3592(MIC>32 ¦ÌM), Pseudomonas aeruginosa 5018(MIC>32 ¦ÌM)"	"[Ref.26450121] 0% hemolysis at 50 ¦ÌM , 0% hemolysis at 100 ¦ÌM , 0% hemolysis at 200 ¦ÌM , 0% hemolysis at 400 ¦ÌM against human red blood cells"	Linear	Free	Free	None	L	"[Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 ¦ÌM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of"	Not found	26450121	Amino Acids.?2016 Feb;48(2):505-22. doi: 10.1007/s00726-015-2104-0.	"Han HM, Gopal R, Park Y"	"Design and membrane-disruption mechanism of charge-enriched AMPs exhibiting cell selectivity, high-salt resistance, and anti-biofilm properties."
DRAMP21140	KGCALVKVRGLTLKVCK	17	AMP72 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix, beta sheet, beta turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.23893489] Gram-positive bacteria : Staphylococcus aureus(MBC=6.88 ¦Ìg/ml, 3.78 ¦ÌM), MRSA(MBC=1.72 ¦Ìg/ml, 0.94 ¦ÌM), Streptococcus agalactiae(MBC>55 ¦Ìg/ml, 100 ¦ÌM);##Gram-negative bacteria : Pseudomonas aeruginosa(MBC=3.30 ¦Ìg/ml, 1.81 ¦ÌM), Escherichia coli(MBC=3.40 ¦Ìg/ml, 1.87 ¦ÌM), Salmonella enteritidis(MBC=3.20 ¦Ìg/ml, 1.76 ¦ÌM), Stenotrophomonas maltophilia(MBC=18.5 ¦Ìg/ml, 10.19 ¦ÌM)"	"[Ref.23893489] <1% hemolysis at 1 ¦Ìg/ml , <1% hemolysis at 12.5 ¦Ìg/ml , 1.5% hemolysis at 100 ¦Ìg/ml , 4.2% hemolysis at 250 ¦Ìg/ml , 12.0% hemolysis at 500 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Free	None	L	[Ref.23893489] The cytotoxicity (vs control) of P72 is 3% against HUVEC (endothelial) cells at a peptide concentration of 100 ¦Ìg/ml. ##The cytotoxicity (vs control) of P72 is 4% agaisnt WI-38 (fibroblast) cells at a peptide concentration of 100 ¦Ìg/ml. #	Not found	23893489	J Pept Sci.?2013 Sep;19(9):554-65. doi: 10.1002/psc.2532.	"Romani AA, Baroni MC, Taddei S, Ghidini F, Sansoni P, Cavirani S, Cabassi CS"	In vitro activity of novel in silico-developed antimicrobial peptides against a panel of bacterial pathogens.
DRAMP21139	RLLRPLLQLLKQKLR	15	GNU7 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae"	"[Ref.23946320] Gram-positive bacteria : Bacillus subtilis(MIC=2 mg/L), Enterococcus faecalis(MIC=2 mg/L), Micrococcus luteus(MIC=2 mg/L), Staphylococcus aureus(MIC=2 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=2 mg/L), Pseudomonas aeruginosa(MIC=2 mg/L), Salmonella typhimurium(MIC=2 mg/L);##Fungi : Candida albicans(MIC=2 mg/L), Cryptococcus neoformans(MIC=2 mg/L), Saccharomyces cerevisiae(MIC=4 mg/L)"	[Ref.23946320] 0% hemolysis at 140 mg/L against human red blood cells	Linear	Free	Free	None	L	"[Ref.23946320] The cell viability of hPBMCs is at peptide concentrations of 4, 8, 16, 32, 64 ¦Ìg/ml"	Not found	23946320	J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.	"Hyun Kim, Ju Hye Jang, Sun Chang Kim and Ju Hyun Cho"	De novo generation of short antimicrobial peptides with enhanced stability and cell specificity
DRAMP21138	RIIRPIIQIIKQKIR	15	GNU6 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae"	"[Ref.23946320] Gram-positive bacteria : Bacillus subtilis(MIC=2 mg/L), Enterococcus faecalis(MIC=2 mg/L), Micrococcus luteus(MIC=2 mg/L), Staphylococcus aureus(MIC=2 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=4 mg/L), Pseudomonas aeruginosa(MIC=2 mg/L), Salmonella typhimurium(MIC=4 mg/L);##Fungi : Candida albicans(MIC=2 mg/L), Cryptococcus neoformans(MIC=2 mg/L), Saccharomyces cerevisiae(MIC=4 mg/L)"	[Ref.23946320] 0% hemolysis at 140 mg/L against human red blood cells	Linear	Free	Free	None	L	"[Ref.23946320] The cell viability of hPBMCs is 102.6%, 102.6%, 107.9%, 96.8% and 97.9% at peptide concentrations of 4, 8, 16, 32, 64 ¦Ìg/ml"	Not found	23946320	J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.	"Hyun Kim, Ju Hye Jang, Sun Chang Kim and Ju Hyun Cho"	De novo generation of short antimicrobial peptides with enhanced stability and cell specificity
DRAMP21137	RVVRPVVQVVKQKVR	15	GNU5 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae"	"[Ref.23946320] Gram-positive bacteria : Bacillus subtilis(MIC=16 mg/L), Enterococcus faecalis(MIC=8 mg/L), Micrococcus luteus(MIC=2 mg/L), Staphylococcus aureus(MIC=4 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=32 mg/L), Pseudomonas aeruginosa(MIC=8 mg/L), Salmonella typhimurium(MIC>64 mg/L);##Fungi : Candida albicans(MIC=2 mg/L), Cryptococcus neoformans(MIC=2 mg/L), Saccharomyces cerevisiae(MIC=2 mg/L)"	[Ref.23946320] 0% hemolysis at 140 mg/L against human red blood cells	Linear	Free	Free	None	L	"[Ref.23946320] The cell viability of hPBMCs is at peptide concentrations of 4, 8, 16, 32, 64 ¦Ìg/ml"	Not found	23946320	J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322.	"Hyun Kim, Ju Hye Jang, Sun Chang Kim and Ju Hyun Cho"	De novo generation of short antimicrobial peptides with enhanced stability and cell specificity
DRAMP21135	RRWWHWWRR	9	P7 (Derived from P5)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=4.33 ¦ÌM, MBC=16 ¦ÌM), Staphylococcus aureus(MIC=11.3 ¦ÌM, MBC=128 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=8.67 ¦ÌM, MBC=128 ¦ÌM)"	[Ref.28372989] MHC5=86.67 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28372989] IC50 > 86.67 ¦ÌM for hPBMCs. The cell viability of hPBMCs is 102.4%, 99.2%, 112.8%, 107.2% and 85.2% at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 ¦ÌM."	Not found	28372989	Biochim Biophys Acta Gen Subj.?2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.	"Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M"	Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
DRAMP21136	HRWWRWWRH	9	P8 (Derived from P5)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=1 ¦ÌM, MBC=1 ¦ÌM), Staphylococcus aureus(MIC=16 ¦ÌM, MBC=32 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=8 ¦ÌM, MBC=32 ¦ÌM)"	[Ref.28372989] MHC5=86.67 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28372989] IC50 > 86.67 ¦ÌM for hPBMCs. The cell viability of hPBMCs is 96%, 98.4%, 86.8%, 84.8% and 88.8% and  at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 ¦ÌM."	Not found	28372989	Biochim Biophys Acta Gen Subj.?2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.	"Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M"	Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
DRAMP21134	HRWWRWWRR	9	P6 (Derived from P5)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=1 ¦ÌM, MBC=1 ¦ÌM), Staphylococcus aureus(MIC=8 ¦ÌM, MBC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=8 ¦ÌM, MBC=32 ¦ÌM)"	[Ref.28372989] MHC5=86.67 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28372989] IC50 > 86.67 ¦ÌM for hPBMCs. The cell viability of hPBMCs is 92.4%, 83.2%, 82.4%, 76% and 68% at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 ¦ÌM."	Not found	28372989	Biochim Biophys Acta Gen Subj.?2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.	"Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M"	Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
DRAMP21133	RRWWRWWRR	9	P5 (Derived from Octa 2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=1 ¦ÌM, MBC=1 ¦ÌM), Staphylococcus aureus(MIC=5.6 ¦ÌM, MBC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=3 ¦ÌM, MBC=16 ¦ÌM)"	[Ref.28372989] MHC5=33.33 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28372989] IC50 = 86.67 ¦ÌM for hPBMCs. The cell viability of hPBMCs is 98%, 96%, 89.6%, 78%, 92.8% at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 ¦ÌM."	Not found	28372989	Biochim Biophys Acta Gen Subj.?2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.	"Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M"	Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
DRAMP21132	RRWHRHWRR	9	P4 (Derived from P5)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=2 ¦ÌM, MBC=8 ¦ÌM), Staphylococcus aureus(MIC=128 ¦ÌM, MBC=128 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=40 ¦ÌM, MBC>128 ¦ÌM)"	[Ref.28372989] MHC5>86.67 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28372989] IC50 > 86.67 ¦ÌM for hPBMCs. The cell viability of hPBMCs is 90.8%, 94.1%, 92%, 95.6% and 86.5% at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 ¦ÌM."	Not found	28372989	Biochim Biophys Acta Gen Subj.?2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.	"Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M"	Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
DRAMP21131	RRHWRWWRR	9	P3 (Derived from P5)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=7.3 ¦ÌM, MBC=64 ¦ÌM), Staphylococcus aureus(MIC=40 ¦ÌM, MBC>128 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=26 ¦ÌM, MBC=128 ¦ÌM)"	[Ref.28372989] MHC5>86.67 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28372989] IC50 > 86.67 ¦ÌM for hPBMCs. The cell viability of hPBMCs is 99.6%, 97.6%, 100%, 99.6% and 93.2% at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 ¦ÌM."	Not found	28372989	Biochim Biophys Acta Gen Subj.?2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.	"Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M"	Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
DRAMP21130	RRWHRWWRR	9	P2 (Derived from P5)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=5.2 ¦ÌM, MBC=32 ¦ÌM), Staphylococcus aureus(MIC=25.6 ¦ÌM, MBC=128 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=14.4 ¦ÌM, MBC>128 ¦ÌM)"	[Ref.28372989] MHC5>86.67 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28372989] IC50 > 86.67 ¦ÌM for hPBMCs. The cell viability of hPBMCs is 99.6%, 98%, 95.6%, 98.8% and 90.4% at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 ¦ÌM."	Not found	28372989	Biochim Biophys Acta Gen Subj.?2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.	"Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M"	Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
DRAMP21129	RRWWRHWRR	9	P1 (Derived from P5)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28372989] Gram-positive bacteria : Bacillus subtilis(MIC=10 ¦ÌM, MBC=32 ¦ÌM), Staphylococcus aureus(MIC=48 ¦ÌM, MBC>128 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=21.33 ¦ÌM, MBC=128 ¦ÌM)"	[Ref.28372989] MHC5>86.67 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28372989] IC50 > 86.67 ¦ÌM for hPBMCs. The cell viability of hPBMCs is 104.0%, 107.6%, 112.4%, 101.6% and 93.2% at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 ¦ÌM."	Not found	28372989	Biochim Biophys Acta Gen Subj.?2017 Jul;1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.	"Bacalum M, Janosi L, Zorila F, Tepes AM, Ionescu C, Bogdan E, Hadade N, Craciun L, Grosu I, Turcu I, Radu M"	Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine.
DRAMP21128	RFRRLRKKFRKRLKKI	16	T9F (Derived from RI16)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25494332] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=128 ¦ÌM), Staphylococcus epidermidis 12228(MIC=32 ¦ÌM), ;##Gram-negative bacteria : Escherichia coli 25922(MIC=64 ¦ÌM), Salmonella typhimurium 7731(MIC=128 ¦ÌM), Pseudomonas aeruginosa 27853(MIC=256 ¦ÌM), Pseudomonas aeruginosa 10419(MIC=256 ¦ÌM), Pseudomonas aeruginosa 21625(MIC=256 ¦ÌM), Pseudomonas aeruginosa 21630(MIC=256 ¦ÌM), Pseudomonas aeruginosa LC(MIC=64 ¦ÌM), Pseudomonas aeruginosa LCCI(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCGE(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCCE(MIC=256 ¦ÌM)"	[Ref.25494332] HC50>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 ¦ÌM	Not found	25494332	PLoS One.?2014 Dec 10;9(12):e114605. doi: 10.1371/journal.pone.0114605.	"Zhu X, Ma Z, Wang J, Chou S, Shan A"	Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.
DRAMP21127	RFRRLRKKKRKRLKKI	16	T9K (Derived from RI16)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25494332] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=128 ¦ÌM), Staphylococcus epidermidis 12228(MIC=128 ¦ÌM), ;##Gram-negative bacteria : Escherichia coli 25922(MIC=128 ¦ÌM), Salmonella typhimurium 7731(MIC=256 ¦ÌM), Pseudomonas aeruginosa 27853(MIC=128 ¦ÌM), Pseudomonas aeruginosa 10419(MIC=256 ¦ÌM), Pseudomonas aeruginosa 21625(MIC=256 ¦ÌM), Pseudomonas aeruginosa 21630(MIC=256 ¦ÌM), Pseudomonas aeruginosa LC(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCCI(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCGE(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCCE(MIC=256 ¦ÌM)"	[Ref.25494332] HC50>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 ¦ÌM	Not found	25494332	PLoS One.?2014 Dec 10;9(12):e114605. doi: 10.1371/journal.pone.0114605.	"Zhu X, Ma Z, Wang J, Chou S, Shan A"	Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.
DRAMP21126	RFRRLRKKIRKRLKKI	16	T9I (Derived from RI16)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25494332] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=256 ¦ÌM), Staphylococcus epidermidis 12228(MIC=32 ¦ÌM), ;##Gram-negative bacteria : Escherichia coli 25922(MIC=128 ¦ÌM), Salmonella typhimurium 7731(MIC=256 ¦ÌM), Pseudomonas aeruginosa 27853(MIC=256 ¦ÌM), Pseudomonas aeruginosa 10419(MIC=256 ¦ÌM), Pseudomonas aeruginosa 21625(MIC=256 ¦ÌM), Pseudomonas aeruginosa 21630(MIC=256 ¦ÌM), Pseudomonas aeruginosa LC(MIC=64 ¦ÌM), Pseudomonas aeruginosa LCCI(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCGE(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCCE(MIC=256 ¦ÌM)"	[Ref.25494332] HC50>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 ¦ÌM	Not found	25494332	PLoS One.?2014 Dec 10;9(12):e114605. doi: 10.1371/journal.pone.0114605.	"Zhu X, Ma Z, Wang J, Chou S, Shan A"	Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.
DRAMP21125	RFRRLRKKWRKRLKKI	16	T9W (Derived from RI16)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25494332] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=128 ¦ÌM), Staphylococcus epidermidis 12228(MIC=64 ¦ÌM), ;##Gram-negative bacteria : Escherichia coli 25922(MIC=64 ¦ÌM), Salmonella typhimurium 7731(MIC=128 ¦ÌM), Pseudomonas aeruginosa 27853(MIC=2 ¦ÌM), Pseudomonas aeruginosa 10419(MIC=4 ¦ÌM), Pseudomonas aeruginosa 21625(MIC=4 ¦ÌM), Pseudomonas aeruginosa 21630(MIC=4 ¦ÌM), Pseudomonas aeruginosa LC(MIC=1 ¦ÌM), Pseudomonas aeruginosa LCCI(MIC=2 ¦ÌM), Pseudomonas aeruginosa LCGE(MIC=4 ¦ÌM), Pseudomonas aeruginosa LCCE(MIC=4 ¦ÌM)"	[Ref.25494332] HC50>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 ¦ÌM	Not found	25494332	PLoS One.?2014 Dec 10;9(12):e114605. doi: 10.1371/journal.pone.0114605.	"Zhu X, Ma Z, Wang J, Chou S, Shan A"	Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.
DRAMP21124	RFRRLRKKTRKRLKKI	16	RI16 (Derived from PMAP-36)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25494332] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=128 ¦ÌM), Staphylococcus epidermidis 12228(MIC=32 ¦ÌM), ;##Gram-negative bacteria : Escherichia coli 25922(MIC=128 ¦ÌM), Salmonella typhimurium 7731(MIC=128 ¦ÌM), Pseudomonas aeruginosa 27853(MIC=256 ¦ÌM), Pseudomonas aeruginosa 10419(MIC=256 ¦ÌM), Pseudomonas aeruginosa 21625(MIC=256 ¦ÌM), Pseudomonas aeruginosa 21630(MIC=256 ¦ÌM), Pseudomonas aeruginosa LC(MIC=32 ¦ÌM), Pseudomonas aeruginosa LCCI(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCGE(MIC=256 ¦ÌM), Pseudomonas aeruginosa LCCE(MIC=256 ¦ÌM)"	[Ref.25494332] HC50>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 ¦ÌM	Not found	25494332	PLoS One.?2014 Dec 10;9(12):e114605. doi: 10.1371/journal.pone.0114605.	"Zhu X, Ma Z, Wang J, Chou S, Shan A"	Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide.
DRAMP21123	KRIVKLlLKWLR	12	KR-12-a5 (7-(D)L) (Derived from LL-37)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28525841] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28525841] MHC10=111 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	Mixed(7 is D)	"[Ref.28525841] The cell viability of mouse macrophage RAW264.7 cells is 100%, 97.4%, 98.1%, 93.6%, 100.8%, 104.5% and 104.5% at peptide concentrations of 0, 4, 8, 16, 32, 64, 128 and 256 ¦ÌM"	Not found	28525841	Eur J Med Chem.?2017 Aug 18;136:428-441. doi: 10.1016/j.ejmech.2017.05.028.	"Kim EY, Rajasekaran G, Shin SY"	"LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity."
DRAMP21122	KRIVKlILKWLR	12	KR-12-a5 (6-(D)L) (Derived from LL-37)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28525841] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=4 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28525841] MHC10=202 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	Mixed(6 is D)	"[Ref.28525841] The cell viability of mouse macrophage RAW264.7 cells is 100%, 101.9%, 118.9%, 107.5%, 111.3%, 110.6% and 110.6% at peptide concentrations of 0, 4, 8, 16, 32, 64, 128 and 256 ¦ÌM"	Not found	28525841	Eur J Med Chem.?2017 Aug 18;136:428-441. doi: 10.1016/j.ejmech.2017.05.028.	"Kim EY, Rajasekaran G, Shin SY"	"LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity."
DRAMP21121	KRIVkLILKWLR	12	KR-12-a5 (5-(D)K) (Derived from LL-37)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28525841] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=8 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28525841] MHC10=79 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	Mixed(5 is D)	"[Ref.28525841] The cell viability of mouse macrophage RAW264.7 cells is 100%, 103.4%, 116.6%, 118.9%, 115.1%, 107.9% and 105.7% at peptide concentrations of 0, 4, 8, 16, 32, 64, 128 and 256 ¦ÌM"	Not found	28525841	Eur J Med Chem.?2017 Aug 18;136:428-441. doi: 10.1016/j.ejmech.2017.05.028.	"Kim EY, Rajasekaran G, Shin SY"	"LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity."
DRAMP21119	KWCFRVCYRGRCYRRCR	17	I11R (Derived from tachyplesin I)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26549611] Gram-positive bacteria : Staphylococcus aureus 209P(MIC=1.56 ¦ÌM);##Gram-negative bacteria : Escherichia coli C600(MIC=1.56 ¦ÌM), Pseudomonas aeruginosa PAO1(MIC=6.25 ¦ÌM)"	[Ref.26549611] MHC2=180 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26549611] No cytotoxicity information found.	Not found	26549611	Biotechnol Appl Biochem. 2017 Jan;64(1):35-42. doi: 10.1002/bab.1456.	"Panteleev PV, Ovchinnikova TV"	Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity.
DRAMP21120	KRIVKLILKWLR	12	KR-12-a5 (Derived from LL-37)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28525841] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=8 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28525841] MHC10=25 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28525841] The cell viability of mouse macrophage RAW264.7 cells is 100%, 116.6%, 112.1%, 115.1%, 112.8%, 106.8% and 108.3% at peptide concentrations of 0, 4, 8, 16, 32, 64, 128 and 256 ¦ÌM"	Not found	28525841	Eur J Med Chem.?2017 Aug 18;136:428-441. doi: 10.1016/j.ejmech.2017.05.028.	"Kim EY, Rajasekaran G, Shin SY"	"LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity."
DRAMP21118	KWCFRVCYRGSCYRRCR	17	I11S (Derived from tachyplesin I)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26549611] Gram-positive bacteria : Staphylococcus aureus 209P(MIC=3.13 ¦ÌM);##Gram-negative bacteria : Escherichia coli C600(MIC=0.8 ¦ÌM), Pseudomonas aeruginosa PAO1(MIC=3.13 ¦ÌM)"	[Ref.26549611] MHC2=190 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26549611] The cell viability of human embryonic fibroblasts HEF is 90.6%, 92.9%, 84.1%, 70.6% and 34.1% at peptide concentrations of 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	26549611	Biotechnol Appl Biochem. 2017 Jan;64(1):35-42. doi: 10.1002/bab.1456.	"Panteleev PV, Ovchinnikova TV"	Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity.
DRAMP21117	KWCFRVCRRGICYRRCR	17	Y8R (Derived from tachyplesin I)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26549611] Gram-positive bacteria : Staphylococcus aureus 209P(MIC=3.13 ¦ÌM);##Gram-negative bacteria : Escherichia coli C600(MIC=1.56 ¦ÌM), Pseudomonas aeruginosa PAO1(MIC=6.25 ¦ÌM)"	[Ref.26549611] MHC2=195 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26549611] No cytotoxicity information found.	Not found	26549611	Biotechnol Appl Biochem. 2017 Jan;64(1):35-42. doi: 10.1002/bab.1456.	"Panteleev PV, Ovchinnikova TV"	Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity.
DRAMP21116	KWCFRVCSRGICYRRCR	17	Y8S (Derived from tachyplesin I)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26549611] Gram-positive bacteria : Staphylococcus aureus 209P(MIC=3.13 ¦ÌM);##Gram-negative bacteria : Escherichia coli C600(MIC=0.8 ¦ÌM), Pseudomonas aeruginosa PAO1(MIC=3.13 ¦ÌM)"	[Ref.26549611] MHC2=310 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26549611] The cell viability of human embryonic fibroblasts HEF is 100%, 92.9%, 87.1%, 72.9%, 60.0% and 45.0% at peptide concentrations of 0, 6.25, 12.5, 25, 50 and 100 ¦ÌM."	Not found	26549611	Biotechnol Appl Biochem. 2017 Jan;64(1):35-42. doi: 10.1002/bab.1456.	"Panteleev PV, Ovchinnikova TV"	Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity.
DRAMP21115	KWCFRRCYRGICYRRCR	17	V6R (Derived from tachyplesin I)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26549611] Gram-positive bacteria : Staphylococcus aureus 209P(MIC>50 ¦ÌM);##Gram-negative bacteria : Escherichia coli C600(MIC=1.56 ¦ÌM), Pseudomonas aeruginosa PAO1(MIC>50 ¦ÌM)"	[Ref.26549611] MHC2=200 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26549611] No cytotoxicity information found.	Not found	26549611	Biotechnol Appl Biochem. 2017 Jan;64(1):35-42. doi: 10.1002/bab.1456.	"Panteleev PV, Ovchinnikova TV"	Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity.
DRAMP21114	KWCFRSCYRGICYRRCR	17	V6S (Derived from tachyplesin I)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26549611] Gram-positive bacteria : Staphylococcus aureus 209P(MIC=6.25 ¦ÌM);##Gram-negative bacteria : Escherichia coli C600(MIC=1.56 ¦ÌM), Pseudomonas aeruginosa PAO1(MIC=12.5 ¦ÌM)"	[Ref.26549611] MHC2=280 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26549611] No cytotoxicity information found.	Not found	26549611	Biotechnol Appl Biochem. 2017 Jan;64(1):35-42. doi: 10.1002/bab.1456.	"Panteleev PV, Ovchinnikova TV"	Improved strategy for recombinant production and purification of antimicrobial peptide tachyplesin I and its analogs with high cell selectivity.
DRAMP21111	LRRAARWARRLLRR	14	ASA (Derived from SLZP)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Sporothrix schenckii, Trichophyton mentagrophytes, Aspergillus fumigatus, Candida parapsilosis"	"[Ref.25069749] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=3.15 ¦Ìg/ml), Bacillus cereus(MIC=3.15 ¦Ìg/ml);##Gram-negative bacteria : E. coli (ATCC 9637)(MIC=25 ¦Ìg/ml), Pseudomonas aeruginosa (ATCC BAA-427)(MIC=25 ¦Ìg/ml), Klebsiella pneumoniae (ATCC 27736)(MIC=6.25 ¦Ìg/ml);##Fungi : Sporothrix schenckii(MIC=12.5 ¦Ìg/ml), Trichophyton mentagrophytes(MIC=100 ¦Ìg/ml), Aspergillus fumigatus(MIC=50 ¦Ìg/ml), Candida parapsilosis (ATCC 22019)(MIC=12.5 ¦Ìg/ml)"	"[Ref.25069749] 3% hemolysis at 10 ¦Ìg/ml , 5% hemolysis at 20 ¦Ìg/ml , 7.5% hemolysis at 30 ¦Ìg/ml , 10% hemolysis at 40 ¦Ìg/ml , 12% hemolysis at 50 ¦Ìg/ml , 13% hemolysis at 60 ¦Ìg/ml , 15% hemolysis at 70 ¦Ìg/ml , 19% hemolysis at 80 ¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.25069749] The cell viability of murine fibroblast cells (3T3) is 100%, 93.6%, 86.8%, 82.9%, 80% and 77.9% at peptide concentrations of 1.5, 3, 4.5, 6 and 9 ¦ÌM."	Not found	25069749	Amino Acids.?2014 Nov;46(11):2531-43. doi: 10.1007/s00726-014-1802-3.	"Ahmad A, Azmi S, Srivastava S, Kumar A, Tripathi JK, Mishra NN, Shukla PK, Ghosh JK"	Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms
DRAMP21112	LRRllRWlRRLLRR	14	DLSA (Derived from SLZP)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Sporothrix schenckii, Trichophyton mentagrophytes, Aspergillus fumigatus, Candida parapsilosis"	"[Ref.25069749] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=3.15 ¦Ìg/ml), Bacillus cereus(MIC=3.15 ¦Ìg/ml);##Gram-negative bacteria : E. coli (ATCC 9637)(MIC=12.5 ¦Ìg/ml), Pseudomonas aeruginosa (ATCC BAA-427)(MIC=12.5 ¦Ìg/ml), Klebsiella pneumoniae (ATCC 27736)(MIC=6.25 ¦Ìg/ml);##Fungi : Sporothrix schenckii(MIC=6.25 ¦Ìg/ml), Trichophyton mentagrophytes(MIC=12.5 ¦Ìg/ml), Aspergillus fumigatus(MIC=6.25 ¦Ìg/ml), Candida parapsilosis (ATCC 22019)(MIC=12.5 ¦Ìg/ml)"	[Ref.25069749] 0% hemolysis at 80 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	"Mixed(4, 5, 8 is D)"	"[Ref.25069749] The cell viability of murine fibroblast cells (3T3) is 84.8%, 83.4%, 76.9%, 72.1% and 62.8% at peptide concentrations of 1.5, 3, 4.5, 6 and 9 ¦ÌM."	Not found	25069749	Amino Acids.?2014 Nov;46(11):2531-43. doi: 10.1007/s00726-014-1802-3.	"Ahmad A, Azmi S, Srivastava S, Kumar A, Tripathi JK, Mishra NN, Shukla PK, Ghosh JK"	Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms
DRAMP21113	LRRPPRWPRRLLRR	14	PSA (Derived from SLZP)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Sporothrix schenckii, Trichophyton mentagrophytes, Aspergillus fumigatus, Candida parapsilosis"	"[Ref.25069749] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=12.5 ¦Ìg/ml), Bacillus cereus(MIC>100 ¦Ìg/ml);##Gram-negative bacteria : E. coli (ATCC 9637)(MIC=25 ¦Ìg/ml), Pseudomonas aeruginosa (ATCC BAA-427)(MIC=100 ¦Ìg/ml), Klebsiella pneumoniae (ATCC 27736)(MIC=12.5 ¦Ìg/ml);##Fungi : Sporothrix schenckii(MIC=100 ¦Ìg/ml), Trichophyton mentagrophytes(MIC>100 ¦Ìg/ml), Aspergillus fumigatus(MIC>100 ¦Ìg/ml), Candida parapsilosis (ATCC 22019)(MIC>100 ¦Ìg/ml)"	[Ref.25069749] 0% hemolysis at 80 ¦Ìg/ml against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.25069749] The cell viability of murine fibroblast cells (3T3) is 100%, 100%, 100%, 99.9%, 84.8% and 82.1% at peptide concentrations of 1.5, 3, 4.5, 6 and 9 ¦ÌM."	Not found	25069749	Amino Acids.?2014 Nov;46(11):2531-43. doi: 10.1007/s00726-014-1802-3.	"Ahmad A, Azmi S, Srivastava S, Kumar A, Tripathi JK, Mishra NN, Shukla PK, Ghosh JK"	Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms
DRAMP21103	RWTWRGSGRWTWR	13	L-RW (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.25683050] Gram-positive bacteria : Staphylococcus aureus(MIC=8 ¦Ìg/ml), Micrococcus luteus(MIC=16 ¦Ìg/ml), Bacillus subtilis(MIC=16 ¦Ìg/ml);##Gram-negative bacteria : Escherichia coli(MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa(MIC=125 ¦Ìg/ml), Acinetobacter baumannii(MIC=32 ¦Ìg/ml), Stenotrophomonas maltophilia(MIC>500 ¦Ìg/ml)"	"[Ref.25683050] 0% hemolysis at 8 mg/L , 3.25% hemolysis at 16 mg/L , 0% hemolysis at 32mg/L  , 0% hemolysis at 64 mg/L , 0% hemolysis at 125 mg/L , 0% hemolysis at  mg/L , 2.5%  hemolysis at 500 mg/L against rabbit red blood cells"	Linear	Acylation (Conjugated with acetyl group)	Amidation	None	L	"[Ref.25683050] The inhibition ratio of I-RW against human bronchial epithelial cell line BEAS-2B cells is 11.3%, 2.1%, 0.5%, 6.2%, 1.5%, 8.2%, 37.4% and 51.8% at peptide concentrations of 2.5, 5, 10, 20, 40, 80, 160 and 320 ¦Ìg/ml"	Not found	25683050	J Pept Sci.?2015 Apr;21(4):274-82. doi: 10.1002/psc.2728.?	"Lanlan Yu, Qiannan Fan, Xiu Yue, Yexuan Maoa and Lingbo Qu"	Activity of a novel-designed antimicrobial peptide and its interaction with lipids
DRAMP21110	LRRLLRWLRRLLRR	14	SLZP (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Sporothrix schenckii, Trichophyton mentagrophytes, Aspergillus fumigatus, Candida parapsilosis"	"[Ref.25069749] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=1.56 ¦Ìg/ml), Bacillus cereus(MIC=3.15 ¦Ìg/ml);##Gram-negative bacteria : E. coli (ATCC 9637)(MIC=25 ¦Ìg/ml), Pseudomonas aeruginosa (ATCC BAA-427)(MIC=25 ¦Ìg/ml), Klebsiella pneumoniae (ATCC 27736)(MIC=3.15 ¦Ìg/ml);##Fungi : Sporothrix schenckii(MIC=3.15 ¦Ìg/ml), Trichophyton mentagrophytes(MIC=6.25 ¦Ìg/ml), Aspergillus fumigatus(MIC=6.25 ¦Ìg/ml), Candida parapsilosis (ATCC 22019)(MIC=6.25 ¦Ìg/ml)"	"[Ref.25069749] 15% hemolysis at 10 ¦Ìg/ml , 25% hemolysis at 20 ¦Ìg/ml , 30% hemolysis at 30 ¦Ìg/ml , 40% hemolysis at 40 ¦Ìg/ml , 50% hemolysis at 50 ¦Ìg/ml , 55% hemolysis at 60 ¦Ìg/ml , 70% hemolysis at 70 ¦Ìg/ml , 80% hemolysis at 80¦Ìg/ml against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.25069749] The cell viability of murine fibroblast cells (3T3) is 85.9%, 77.5%, 73.7%, 50.0%, 23.7% and 0% at peptide concentrations of 1.5, 3, 4.5, 6 and 9 ¦ÌM."	Not found	25069749	Amino Acids.?2014 Nov;46(11):2531-43. doi: 10.1007/s00726-014-1802-3.	"Ahmad A, Azmi S, Srivastava S, Kumar A, Tripathi JK, Mishra NN, Shukla PK, Ghosh JK"	Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms
DRAMP21109	GIGGALLSAKAALGLAKGLAEHFAN	25	"FPA-Bombinin-BO (toads, amphibians, animals)"	No entry found	Not found	Not found	"Asian bombinid toad species, Bombina orientalis"	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.25056849] Gram-positive bacteria : Staphylococcus aureus(MIC=7 ¦ÌM, MBC=14 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=14 ¦ÌM, MBC=14 ¦ÌM);##Fungi : Candida albicans(MIC=7 ¦ÌM, MBC=14 ¦ÌM)"	[Ref.25056849] 100% hemolysis at 125 mg/L against horse red blood cells	Linear	Free	Amidation	None	L	[Ref.25056849] No cytotoxicity information found	Not found	25056849	Chem Biol Drug Des.?2015 Mar;85(3):259-67. doi: 10.1111/cbdd.12396.	"Xiaojuan Hou, Qiang Du, Renjie Li, Mei Zhou, Hui Wang, Lei Wang, Can Guo, Tianbao Chen and Chris Shaw"	"Feleucin-BO1: A Novel Antimicrobial Non-Apeptide Amide from the Skin Secretion of the Toad, Bombina orientalis, and Design of a Potent Broad-Spectrum Synthetic Analogue, Feleucin-K3"
DRAMP21108	FLKLLKKLL	9	Feleucin-K3 (Derived from Feleucin-BO1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	"In F-K3, these latter residues are substituted with Lys (K) residues, whose side-chains occupied the same positions, producing a model cationic amphipathic character in this analogue."	None	Function: Antibacterial activity against Gram-positive bacteria	"[Ref.25056849] Gram-positive bacteria : Staphylococcus aureus(MIC=34 ¦ÌM, MBC=128 ¦ÌM)"	[Ref.25056849] 100% hemolysis at >250 mg/L against horse red blood cells	Linear	Free	Amidation	None	L	[Ref.25056849] No cytotoxicity information found	Not found	25056849	Chem Biol Drug Des.?2015 Mar;85(3):259-67. doi: 10.1111/cbdd.12396.	"Xiaojuan Hou, Qiang Du, Renjie Li, Mei Zhou, Hui Wang2, Lei Wang2, Can Guo, Tianbao Chen and Chris Shaw"	"Feleucin-BO1: A Novel Antimicrobial Non-Apeptide Amide from the Skin Secretion of the Toad, Bombina orientalis, and Design of a Potent Broad-Spectrum Synthetic Analogue, Feleucin-K3"
DRAMP21104	GIGGALLNVGKVALKGLAKGLAEHFAN	27	"Feleucin-2 (toads, amphibians, animals)"	X5JB11?	Belongs to the?bombinin family.	feleucin-2	Bombina variegata (Yellow-bellied toad)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.25003126] Gram-positive bacteria : Staphylococcus aureus(MIC=8 mg/L, MBC=32 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=32 mg/L, MBC=32 mg/L);##Fungi : Candida albicans(MIC=32 mg/L, MBC=32 mg/L)"	[Ref.25003126] 100% hemolysis at 64 mg/L against horse red blood cells	Linear	Free	Amidation	None	L	[Ref.25003126] No cytotoxicity information found	Not found	25003126	Biomed Res Int. 2014;2014:671362. doi: 10.1155/2014/671362.	"Bing Bai, Xiaojuan Hou, Lei Wang, Lilin Ge, Yu Luo, Chengbang Ma, Mei Zhou, Jinao Duan, Tianbao Chen, and Chris Shaw"	Feleucins: Novel Bombinin Precursor-Encoded Nonapeptide Amides from the Skin Secretion of Bombina variegata
DRAMP21107	FLGLLGSLL	9	"Feleucin-BO1 (toads, amphibians, animals)"	No entry found	Not found	Not found	"Asian bombinid toad species, Bombina orientalis"	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Not found	Alpha helix	"The Phe (F) and Leu (L) residue side-chains are oriented on one side of the peptide In feleucin-BO1, while the short side-chains of the hydrophilic Gly (G) and Ser (S) residues are oriented on the other."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.25056849] Gram-positive bacteria : Staphylococcus aureus(MIC=3 ¦ÌM, MBC=6 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=12 ¦ÌM, MBC=25 ¦ÌM);##Fungi : Candida albicans(MIC=6 ¦ÌM, MBC=12 ¦ÌM)"	[Ref.25056849] 100% hemolysis at 80 mg/L against horse red blood cells	Linear	Free	Amidation	None	L	[Ref.25056849] No cytotoxicity information found	Not found	25056849	Chem Biol Drug Des.?2015 Mar;85(3):259-67. doi: 10.1111/cbdd.12396.	"Xiaojuan Hou, Qiang Du, Renjie Li, Mei Zhou, Hui Wang, Lei Wang, Can Guo, Tianbao Chen and Chris Shaw"	"Feleucin-BO1: A Novel Antimicrobial Non-Apeptide Amide from the Skin Secretion of the Toad, Bombina orientalis, and Design of a Potent Broad-Spectrum Synthetic Analogue, Feleucin-K3"
DRAMP21232	GIMDTVKNAAKNLAGQLLDKLKCKITAC	28	"Ranatuerin-2PLx (R2PLx; Frogs, Amphibians, Animals)"	A0A3P8MS06	Belongs to the?frog skin active peptide (FSAP) family.?Brevinin subfamily.	Not found	Lithobates palustris (Pickerel frog) (Rana palustris)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	"Random coil, alpha helix"	The CD spectra of both peptides shows the pattern of random coil in aqueous solution and a typical ¦Á-helix CD spectra in 50% of TFE solution.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.30279210] Gram-positive bacteria : Staphylococcus aureus(NCTC 10788)(MIC=32 ¦ÌM, MBC=128 ¦ÌM), MRSA (ATCC 12493)(MIC=256 ¦ÌM, MBC=512 ¦ÌM), Enterococcus faecalis(NCTC 12697)(MIC=128 ¦ÌM, MBC=512 ¦ÌM);##Gram-negative bacteria : Escherichia coli(NCTC 10418)(MIC=32 ¦ÌM, MBC=64 ¦ÌM), Pseudomonas aeruginosa(ATCC 27853)(MIC>512 ¦ÌM, MBC>512 ¦ÌM);##Fungi : Candida albicans(NCTC 1467)(MIC=256 ¦ÌM, MBC=512 ¦ÌM)"	"[Ref.30279210] 0% hemolysis at 4 ¦ÌM , 1% hemolysis at 8 ¦ÌM , 5% hemolysis at 16 ¦ÌM , 10% hemolysis at 32 ¦ÌM , 13% hemolysis at 64 ¦ÌM , 20% hemolysis at 128 ¦ÌM , 30% hemolysis at 256 ¦ÌM , 44% hemolysis at 512 ¦ÌM against human red blood cells"	Linear	Free	Free	None	L	[Ref.30279210] No cytotoxicity information found	Not found	30279210	Biosci Rep.?2018 Nov 9;38(6). pii: BSR20180710. doi: 10.1042/BSR20180710.	"Chen X,?Zhang L,?Ma C,?Zhang Y,?Xi X,?Wang L,?Zhou M,?Burrows JF,?Chen T"	"A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells."
DRAMP21231	KKKKKKNGFAAWGAFGA	17	S-6K-F17-3GN (Derived from S-6K-F17)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Not found	"Substitutions with polar, known ¡®helix-breaker¡¯ Gly residues led to losses in helical character until finally the peptide containing 3 Gly and 1 Asn (S- 6K-F17-3GN) shows a severe loss in helical structure."	None	Function: Antibacterial activity against Gram-negative bacteria	[Ref.29275987] Gram-negative bacteria : Escherichia coli(MIC=4.2 ¦ÌM)	[Ref.29275987] MHC2=587 ¦ÌM against human red blood cells	Cyclic	Free	Amidation (Ala17)	The 'A' at position 10 and 14 are 2-(4'-pentenyl)alanine residues and there is a hydrocarbon staple crosslinking them.	L	No cytotoxicity information found	Not found	29275987	Bioorg Med Chem.?2018 Mar 15;26(6):1189-1196. doi: 10.1016/j.bmc.2017.10.020.	"Stone TA, Cole GB, Nguyen HQ, Sharpe S, Deber CM"	Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides.
DRAMP21230	KKKKKKAGFAAWGAFGA	17	S-6K-F17-3G (Derived from S-6K-F17)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria	[Ref.29275987] Gram-negative bacteria : Escherichia coli(MIC=4.2 ¦ÌM)	[Ref.29275987] MHC2=128 ¦ÌM against human red blood cells	Cyclic	Free	Amidation (Ala17)	The 'A' at position 10 and 14 are 2-(4'-pentenyl)alanine residues and there is a hydrocarbon staple crosslinking them.	L	No cytotoxicity information found	Not found	29275987	Bioorg Med Chem.?2018 Mar 15;26(6):1189-1196. doi: 10.1016/j.bmc.2017.10.020.	"Stone TA, Cole GB, Nguyen HQ, Sharpe S, Deber CM"	Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides.
DRAMP21229	KKKKKKAGFAAWAAFGA	17	S-6K-F17-2G (Derived from S-6K-F17)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-negative bacteria	[Ref.29275987] Gram-negative bacteria : Escherichia coli(MIC=1.6 ¦ÌM)	[Ref.29275987] MHC2=15 ¦ÌM against human red blood cells	Cyclic	Free	Amidation (Ala17)	The 'A' at position 10 and 14 are 2-(4'-pentenyl)alanine residues and there is a hydrocarbon staple crosslinking them.	L	No cytotoxicity information found	Not found	29275987	Bioorg Med Chem.?2018 Mar 15;26(6):1189-1196. doi: 10.1016/j.bmc.2017.10.020.	"Stone TA, Cole GB, Nguyen HQ, Sharpe S, Deber CM"	Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides.
DRAMP21227	ILKKIWKPIKKLF	13	IsCT-P (Derived from IsCT)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.16871429] Gram-positive bacteria : Staphylococcus aureus (KCTC 1621)(MIC=1 ¦ÌM), Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 ¦ÌM), MRSA (CCARM 3001)(MIC=2 ¦ÌM), MRSA (CCARM 3543)(MIC=1 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=1 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM), MDRPA (CCARM 2095)(MIC=1 ¦ÌM)"	[Ref.16871429] HC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.16871429] No cytotoxicity information found	Not found	16871429	Biotechnol Lett.?2006 Sep;28(18):1431-7.?	"Lim SS,?Yoon SP,?Park Y,?Zhu WL,?Park IS,?Hahm KS,?Shin SY"	Mechanism of antibacterial action of a synthetic peptide with an Ala-peptoid residue based on the scorpion-derived antimicrobial peptide IsCT.
DRAMP21228	ILKKIWKaIKKLF	13	IsCT-a (Derived from IsCT-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.16871429] Gram-positive bacteria : Staphylococcus aureus (KCTC 1621)(MIC=1 ¦ÌM), Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=1 ¦ÌM), MRSA (CCARM 3001)(MIC=2 ¦ÌM), MRSA (CCARM 3543)(MIC=1 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=2 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM), MDRPA (CCARM 2095)(MIC=2 ¦ÌM)"	[Ref.16871429] HC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	The 'a' in sequence is Ala peptoid residue (N-methylglycine)	L	[Ref.16871429] No cytotoxicity information found	Not found	16871429	Biotechnol Lett.?2006 Sep;28(18):1431-7.?	"Lim SS,?Yoon SP,?Park Y,?Zhu WL,?Park IS,?Hahm KS,?Shin SY"	Mechanism of antibacterial action of a synthetic peptide with an Ala-peptoid residue based on the scorpion-derived antimicrobial peptide IsCT.
DRAMP21225	KKFkWWWkFKK	11	STPk (Derived from STP)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.17604338] Gram-positive bacteria : Staphylococcus epidermidis(KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus(KCTC 1621)(MIC=1 ¦ÌM), MRSA1 (CCARM 3001)(MIC=2 ¦ÌM), MRSA2 (CCARM 3543)(MIC=0.5 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=1 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=2 ¦ÌM), MDRPA1 (CCARM 2095)(MIC=4 ¦ÌM), MDRPA2 (CCARM 2109)(MIC=8 ¦ÌM)"	[Ref.17604338] MHC10>200 ¦ÌM against human red blood cells	Linear	Free	Amidation	The 'k' in sequence is lysine peptoid residue [NH2-(CH2)4-NH-CH2-COOH]	L	[Ref.17604338] No cytotoxicity information found	Not found	17604338	J Pept Sci.?2007 Aug;13(8):529-35.	"Zhu WL,?Hahm KS,?Shin SY"	Cathelicidin-derived Trp/Pro-rich antimicrobial peptides with lysine peptoid residue (Nlys): therapeutic index and plausible mode of action.
DRAMP21226	ILkWKWkWWkWRR	13	Ink (Derived from IN)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.17604338] Gram-positive bacteria : Staphylococcus epidermidis(KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus(KCTC 1621)(MIC=1 ¦ÌM), MRSA1 (CCARM 3001)(MIC=2 ¦ÌM), MRSA2 (CCARM 3543)(MIC=1 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=2 ¦ÌM), MDRPA1 (CCARM 2095)(MIC=4 ¦ÌM), MDRPA2 (CCARM 2109)(MIC=8 ¦ÌM)"	[Ref.17604338] MHC10>200 ¦ÌM against human red blood cells	Linear	Free	Amidation	The 'k' in sequence is lysine peptoid residue [NH2-(CH2)4-NH-CH2-COOH]	L	[Ref.17604338] No cytotoxicity information found	Not found	17604338	J Pept Sci.?2007 Aug;13(8):529-35.	"Zhu WL,?Hahm KS,?Shin SY"	Cathelicidin-derived Trp/Pro-rich antimicrobial peptides with lysine peptoid residue (Nlys): therapeutic index and plausible mode of action.
DRAMP21223	ILKKIWKpIKKLF	13	IsCT-p (Derived from IsCT-P)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil	This result indicated that D-Pro in the central position of a short a-helical peptide provides more remarkable structural flexibility than L-Pro.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.16040002] Gram-positive bacteria : Staphylococcus aureus(KCTC 1621)(MIC=1 ¦ÌM), MRSA (CCARM 3001)(MIC=2 ¦ÌM), MRSA (CCARM 3543)(MIC=1 ¦ÌM), Bacillus subtilis(KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=1 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=2 ¦ÌM), MDRPA (CCARM 2095)(MIC=2 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.16040002] 0% hemolysis at 200 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	Mixed(D-Pro8)	[Ref.16040002] No cytotoxicity information found	Not found	16040002	Biochem Biophys Res Commun.?2005 Sep 9;334(4):1329-35.	"Lim SS, Kim Y, Park Y, Kim JI, Park IS, Hahm KS, Shin SY"	The role of the central L- or D-Pro residue on structure and mode of action of a cell-selective alpha-helical IsCT-derived antimicrobial peptide.
DRAMP21224	VRRPkWWWkFLRR	13	TPk (Derived from TP)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.17604338] Gram-positive bacteria : Staphylococcus epidermidis(KCTC 1917)(MIC=1 ¦ÌM), Staphylococcus aureus(KCTC 1621)(MIC=1 ¦ÌM), MRSA1 (CCARM 3001)(MIC=1 ¦ÌM), MRSA2 (CCARM 3543)(MIC=0.5 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=2 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=4 ¦ÌM), MDRPA1 (CCARM 2095)(MIC=4 ¦ÌM), MDRPA2 (CCARM 2109)(MIC=8 ¦ÌM)"	[Ref.17604338] MHC10>200 ¦ÌM against human red blood cells	Linear	Free	Amidation	The 'k' in sequence is lysine peptoid residue [NH2-(CH2)4-NH-CH2-COOH]	L	[Ref.17604338] No cytotoxicity information found	Not found	17604338	J Pept Sci.?2007 Aug;13(8):529-35.	"Zhu WL,?Hahm KS,?Shin SY"	Cathelicidin-derived Trp/Pro-rich antimicrobial peptides with lysine peptoid residue (Nlys): therapeutic index and plausible mode of action.
DRAMP21222	IirKIirK	8	Control-4D (Derived from IK12-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=125 mg/L), Staphylococcus aureus(MIC>500 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=31.3 mg/L), Pseudomonas aeruginosa(MIC=125 mg/L);##Fungi : Candida albicans(MIC=62.5 mg/L)"	[Ref.24211081] HC10>2000 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	"Mixed(D-Ile2, D-Arg3, D-Ile6, D-Arg7)"	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21221	iirkiirk	8	Control-all D (Derived from IK12-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC>500 mg/L), Staphylococcus aureus(MIC>500 mg/L);##Gram-negative bacteria : Escherichia coli(MIC>500 mg/L), Pseudomonas aeruginosa(MIC>500 mg/L);##Fungi : Candida albicans(MIC=250 mg/L)"	[Ref.24211081] HC10>2000 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	D	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21219	irvkirvkirvk	12	IK12-all D (Derived from IK12-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=1.0 mg/L), Staphylococcus aureus(MIC=7.8 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=7.8 mg/L), Pseudomonas aeruginosa(MIC=15.6 mg/L);##Fungi : Candida albicans(MIC=31.3 mg/L)"	[Ref.24211081] HC10>125 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	D	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21220	IIRKIIRK	8	Control-all L (Derived from IK12-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC>500 mg/L), Staphylococcus aureus(MIC>500 mg/L);##Gram-negative bacteria : Escherichia coli(MIC>500 mg/L), Pseudomonas aeruginosa(MIC>500 mg/L);##Fungi : Candida albicans(MIC=500 mg/L)"	[Ref.24211081] HC10>2000 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	L	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21218	IRVKIRVKIRVK	12	IK12-all L (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Beta sheet	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=2.0 mg/L), Staphylococcus aureus(MIC=31.3 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=15.6 mg/L), Pseudomonas aeruginosa(MIC=62.5 mg/L);##Fungi : Candida albicans(MIC=125 mg/L)"	[Ref.24211081] HC10>125 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	L	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21217	IRIkIrIK	8	IK8-2D (Derived from IK8-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=3.9 mg/L), Staphylococcus aureus(MIC=31.3 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=15.6 mg/L), Pseudomonas aeruginosa(MIC=7.8 mg/L);##Fungi : Candida albicans(MIC=3.9 mg/L)"	[Ref.24211081] HC10=1600 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	"Mixed (D-Lys4, D-Arg6)"	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21215	irik	4	IK4-all D (Derived from IK8-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC>500 mg/L), Staphylococcus aureus(MIC>500 mg/L);##Gram-negative bacteria : Escherichia coli(MIC>500 mg/L), Pseudomonas aeruginosa(MIC>500 mg/L);##Fungi : Candida albicans(MIC>500 mg/L)"	[Ref.24211081] HC10>2000 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	D	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21216	IrIkIrIk	8	IK8-4D (Derived from IK8-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC>500 mg/L), Staphylococcus aureus(MIC>500 mg/L);##Gram-negative bacteria : Escherichia coli(MIC>500 mg/L), Pseudomonas aeruginosa(MIC>500 mg/L);##Fungi : Candida albicans(MIC>500 mg/L)"	[Ref.24211081] HC10>2000 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	"Mixed (D-Arg2, D-Lys4, D-Arg6, D-Lys8)"	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21213	irikirik	8	IK8-all D (Derived from IK8-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=2.0 mg/L), Staphylococcus aureus(MIC=3.9 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=3.9 mg/L), Pseudomonas aeruginosa(MIC=7.8 mg/L);##Fungi : Candida albicans(MIC=3.9 mg/L)"	[Ref.24211081] HC10=1750 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	D	"[Ref.24211081] The cell viability of mouse alveolar macrophage RAW264.7 cells is 100%, 100%, 95%, 90%, 83.8%, 86.2%, 50%, 8.8% and 5% at peptide concentrations of 1, 2, 4, 8, 16, 31, 62, 100 and 125 mg/L. ##The cell viability of human fetatl lung fibrobl"	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21214	irikir	6	IK6-all D (Derived from IK8-all L)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=31.3 mg/L), Staphylococcus aureus(MIC=250 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=125 mg/L), Pseudomonas aeruginosa(MIC=250 mg/L);##Fungi : Candida albicans(MIC=15.6 mg/L)"	[Ref.24211081] HC10>2000 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	D	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21212	IRIKIRIK	8	IK8-all L (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Beta sheet	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.24211081] Gram-positive bacteria : Staphylococcus epidermidis(MIC=3.9 mg/L), Staphylococcus aureus(MIC=62.5 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=15.6 mg/L), Pseudomonas aeruginosa(MIC=31.3 mg/L);##Fungi : Candida albicans(MIC=3.9 mg/L)"	[Ref.24211081] HC10=2000 mg/L against rabbit red blood cells	Linear	Free	Amidation	None	L	[Ref.24211081] No cytotoxicity information found	Not found	24211081	Biomaterials.?2014 Jan;35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.	"Ong ZY,?Cheng J,?Huang Y,?Xu K,?Ji Z,?Fan W,?Yang YY"	"Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic ¦Â-sheet forming peptide amphiphiles."
DRAMP21211	HLLKRVQRELIRWLDWLK	18	"AmyI-1-18 (N3L, G12R) (Derived from AmyI-1-18)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=2.9¡À0.2 ¦ÌM)	[Ref.27478151] 14% hemolysis at 50 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151] No cytotoxicity information found	Not found	27478151	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-18 and its amino acid-substituted?analogs.
DRAMP21208	HLNKRVQRLLIGWLDWLK	18	AmyI-1-18 (E9L) (Derived from AmyI-1-18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=3.7¡À1.5 ¦ÌM). 	[Ref.27478151] 5% hemolysis at 50 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151] No cytotoxicity information found	Not found	27478151	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-23 and its amino acid-substituted?analogs.
DRAMP21209	HLNKRVQRLLIRWLDWLK	18	"AmyI-1-18 (E9L, G12R) (Derived from AmyI-1-18)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=4.9¡À0.5 ¦ÌM)	[Ref.27478151] 9% hemolysis at 50 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151] No cytotoxicity information found	Not found	27478151	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-18 and its amino acid-substituted?analogs.
DRAMP21205	HLNKRVQRELIRWLDWLK	18	AmyI-1-18 (G12R) (Derived from AmyI-1-18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antifungal activity against Candida albicans	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=4.6¡À1.1 ¦ÌM). ##[Ref.26850838] Fungi: Candida albicans(IC50=61¡À8 ¦ÌM)	[Ref.27478151] 2% hemolysis at 50 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151##26850840] No cytotoxicity information found	Not found	27478151##26850840	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008. ##Biopolymers. 2016 Mar;106(2):219-229. doi: 10.1002/bip.22819.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	"Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-20 and its amino acid-substituted?analogs. ##Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from ¦Á-amylase of rice."
DRAMP21210	HLLKRVQRLLIGWLDWLK	18	"AmyI-1-18 (N3L, E9L) (Derived from AmyI-1-18)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=4.2¡À0.5 ¦ÌM)	[Ref.27478151] 14% hemolysis at 50 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151] No cytotoxicity information found	Not found	27478151	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-18 and its amino acid-substituted?analogs.
DRAMP21207	HLLKRVQRELIGWLDWLK	18	AmyI-1-18 (N3L) (Derived from AmyI-1-18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antifungal activity against Candida albicans	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=2.5¡À0.7 ¦ÌM). ##[Ref.26850838] Fungi: Candida albicans(IC50=58¡À22 ¦ÌM)	[Ref.27478151] 3% hemolysis at 50 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151##26850842] No cytotoxicity information found	Not found	27478151##26850842	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008. ##Biopolymers. 2016 Mar;106(2):219-229. doi: 10.1002/bip.22821.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	"Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-22 and its amino acid-substituted?analogs. ##Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from ¦Á-amylase of rice."
DRAMP21206	HLNKRVQRELIGWLRWLK	18	AmyI-1-18 (D15R) (Derived from AmyI-1-18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antifungal activity against Candida albicans	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=11¡À1 ¦ÌM). ##[Ref.26850838] Fungi: Candida albicans(IC50=31¡À4 ¦ÌM)	[Ref.27478151] 2% hemolysis at 50 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151##26850841] No cytotoxicity information found	Not found	27478151##26850841	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008. ##Biopolymers. 2016 Mar;106(2):219-229. doi: 10.1002/bip.22820.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	"Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-21 and its amino acid-substituted?analogs. ##Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from ¦Á-amylase of rice."
DRAMP21204	HLNKRVQRELRGWLDWLK	18	AmyI-1-18 (I11R) (Derived from AmyI-1-18)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antifungal activity against Candida albicans	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=10¡À2 ¦ÌM). ##[Ref.26850838] Fungi: Candida albicans(IC50=62¡À2 ¦ÌM)	[Ref.27478151] 1% hemolysis at 50 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151##26850839] No cytotoxicity information found	Not found	27478151##26850839	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008. ##Biopolymers. 2016 Mar;106(2):219-229. doi: 10.1002/bip.22818.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	"Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-19 and its amino acid-substituted?analogs. ##Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from ¦Á-amylase of rice."
DRAMP21203	HLNKRVQRELIGWLDWLK	18	"AmyI-1-18 (Oryza sativa L., Angiospermae, Plants)"	P17654	Belongs to the?glycosyl hydrolase 13 family.	AMY1.1	Oryza sativa subsp. japonica (Rice)	"Antimicrobial, Antibacterial, Anti-Gram-, Antifungal"	Protein level	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Antifungal activity gaginst Candida albicans. Important for breakdown of endosperm starch during germination.	[Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=13¡À3 ¦ÌM). ##[Ref.26850838] Fungi: Candida albicans(IC50=64¡À2 ¦ÌM)	[Ref.27478151] 0.1% hemolysis at 100 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.27478151##26850838] No cytotoxicity information found	Not found	27478151##26850838	J Biosci Bioeng.?2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008. ##Biopolymers. 2016 Mar;106(2):219-229. doi: 10.1002/bip.22817.	"Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T"	"Antimicrobial?activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-18 and its amino acid-substituted?analogs. ##Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from ¦Á-amylase of rice."
DRAMP21202	FKKLKKLFKKILKLK	15	HPA3NT3-analog (Derived from HPA3NT3)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli"	"[Ref.19642077] Gram-positive bacteria : Staphylococcus aureus(MIC=8 ¦ÌM), Bacillus subtilis(MIC=8 ¦ÌM), Listeria monocytogenes(MIC=4 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=8 ¦ÌM), Salmonella typhimurium(MIC=1 ¦ÌM), Pseudomonas aeruginosa(MIC=2 ¦ÌM);##Fungi : Candida albicans(MIC=4-8 ¦ÌM), Trichosporon beigelli(MIC=1 ¦ÌM)"	"[Ref.19642077] 0% hemolysis at 100 ¦ÌM , 3% hemolysis at 200 ¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	[Ref.19642077] No cytotoxicity information found.	Not found	19642077	J Pept Sci.?2009 Sep;15(9):589-94. doi: 10.1002/psc.1155.	"Gopal R, Park SC, Ha KJ, Cho SJ, Kim SW, Song PI, Nah JW, Park Y, Hahm KS"	Effect of Leucine and Lysine substitution on the antimicrobial activity and evaluation of the mechanism of the HPA3NT3 analog peptide.
DRAMP21201	GIGKFLHSAKKWGKAFVGEIMNS	23	"Magainin 2a (M2a; Frogs, Amphibians, Animals)"	No entry found	Belongs to the gastrin/cholecystokinin family. Magainin subfamily	N/A	From frog	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=128 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=128 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=128 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=128 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=128 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=32 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=64 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=64 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=64 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=128 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=32 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=128 ¦Ìg/ml)"	[Ref.18586467] MHC=128 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21200	GYKYINNIIKYINKFFKYIW	20	GW-M4 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=8 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=8 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=8 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=32 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=32 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=128 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=32 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=16 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=16 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=128 ¦Ìg/ml)"	[Ref.18586467] MHC=4 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21199	GANAAKKFANLIKKIFNYIW	20	GW-M3 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=8 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=16 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=16 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=32 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=128 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=128 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=32 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=16 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=16 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=128 ¦Ìg/ml)"	[Ref.18586467] MHC=8 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21198	GANAAKKLATFAKKIFTAYW	20	GW-M1 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=64 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=64 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=64 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=128 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=128 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=256 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=128 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=64 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=32 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=32 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=16 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=256 ¦Ìg/ml)"	[Ref.18586467] MHC=64 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21197	GLTFLKKILNFAKKIYTAIW	20	GW-H3 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=16 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=16 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=16 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=8 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=32 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=32 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=128 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=32 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=32 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=16 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=64 ¦Ìg/ml)"	[Ref.18586467] MHC=8 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21196	GYNYAKKLANLAKKFANALW	20	GW-H1 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=16 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=8 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=32 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=16 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=64 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=32 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=32 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=8 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=8 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=32 ¦Ìg/ml)"	[Ref.18586467] MHC=128 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21195	GATYAKKIIKTITKIATTAW	20	GW-A5 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=128 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=64 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=128 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=128 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=128 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=128 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=64 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=64 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=16 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=64 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=32 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=128 ¦Ìg/ml)"	[Ref.18586467] MHC=128 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21194	GAKALTKAATAFTKFYKTIW	20	GW-A4 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=128 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=64 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=128 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=64 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=128 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=128 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=16 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=64 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=16 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=16 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=128 ¦Ìg/ml)"	[Ref.18586467] MHC=64 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21193	GAKYAKIIYNYLKKIANALW	20	GW-A2 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=8 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=16 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=16 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=32 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=32 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=64 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=128 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=128 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=64 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=16 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=128 ¦Ìg/ml)"	[Ref.18586467] MHC=8 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21192	GAKYAKYIYNFYKYIAKYIW	20	GW-A1 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=128 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=64 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=128 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=128 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=128 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=256 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=128 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=64 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=64 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=64 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=64 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=256 ¦Ìg/ml)"	[Ref.18586467] MHC=8 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21191	GIKIAKKAITIAKKIAKIYW	20	GW-Q6 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=32 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=4 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=32 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=32 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=128 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=128 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=16 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=16 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=8 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=32 ¦Ìg/ml)"	[Ref.18586467] MHC=128 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21190	GANALKKYFTILKKFFKLAW	20	GW-Q5 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=16 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=16 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=16 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=16 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=64 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=64 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=64 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=16 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=8 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=8 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=32 ¦Ìg/ml)"	[Ref.18586467] MHC=4 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21189	GANAAKKFATIAKKFINYLW	20	GW-Q4 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=16 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=8 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=16 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=8 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=128 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=128 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=32 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=16 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=16 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=8 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=8 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=64 ¦Ìg/ml)"	[Ref.18586467] MHC=128 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21188	GANLAKKFYTYINKFINYAW	20	GW-Q3 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=128 ¦Ìg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=64 ¦Ìg/ml), Staphylococcus aureus (BCRC 10781)(MIC=128 ¦Ìg/ml), Listeria monocytogenes (BCRC 14845)(MIC=128 ¦Ìg/ml), Streptococcus bovis (BCRC 14729)(MIC=256 ¦Ìg/ml), Streptococcus iniae (laboratory strain)(MIC=256 ¦Ìg/ml), Lactococcus garvieae (laboratory strain)(MIC=256 ¦Ìg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=128 ¦Ìg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=128 ¦Ìg/ml), Escherichia coli (BCRC 10675)(MIC=64 ¦Ìg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=32 ¦Ìg/ml), Enterobacter cloacae (BCRC 10401)(MIC=64 ¦Ìg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=128 ¦Ìg/ml)"	[Ref.18586467] MHC=128 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.18586467] No cytotoxicity information found.	Not found	18586467	Int J Antimicrob?Agents.?2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.	"Chou HT, Kuo TY, Chiang JC, Pei MJ, Yang WT, Yu HC, Lin SB, Chen WJ"	Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
DRAMP21187	WLRAFRRLVRRLARLLRR	18	WRL4 (Derived from leucocin A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix, beta sheet, turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=6.65 ¦ÌM), Staphylococcus aureus 1.160(MIC=1.66 ¦ÌM), Listeria monocytogenes 21662(MIC=3.32 ¦ÌM), Listeria monocytogenes 21633(MIC=3.32 ¦ÌM), Bacillus cereus 63301(MIC=53.18 ¦ÌM), Micrococcus luteus 28001(MIC=13.29 ¦ÌM), Bacillus pumilus 63202(MIC=26.59 ¦ÌM), Pseudomonas fluorescens 21620(MIC=53.18 ¦ÌM), MRSA 43300(MIC=3.32 ¦ÌM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC=3.32 ¦ÌM), Escherichia coli 25922(MIC=13.29 ¦ÌM), Escherichia coli 35150(MIC=26.59 ¦ÌM), Salmonella paratyphi-A 20501(MIC=6.65 ¦ÌM), Salmonella paratyphi paratyphi-B 21495(MIC=3.32 ¦ÌM), Salmonella paratyphi paratyphi-C 21512(MIC=6.65 ¦ÌM), Shigella flexneri 51571(MIC=1.66 ¦ÌM), Salmonella choleraesuis 13312(MIC=13.29 ¦ÌM), Salmonella typhimurium 51005(MIC>53.18 ¦ÌM), Salmonella enteritidis 21527(MIC>53.28 ¦ÌM), Vibrio parahemolyticus 21617(MIC=6.65 ¦ÌM);##Fungi : Candida albicans 10231(MIC=26.59 ¦ÌM)"	[Ref.28002968] MHC10=53.18 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28002968] The cell viability of RAW264.7 cells induced by WRL4 is 91.27%, 90.42%, 81.13%, 73.24%, 70.14%, 69.30%, 56.62%, 51.27% and 48.25% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	28002968	J Med Chem.?2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.	"Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X"	Insights into the?Antimicrobial?Activity and Cytotoxicity of Engineered ¦Á-Helical?PeptideAmphiphiles.
DRAMP21186	WLRAFRRLVRRLARGLRR	18	WRL3 (Derived from leucocin A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix, beta sheet, turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=0.43 ¦ÌM), Staphylococcus aureus 1.160(MIC=0.43 ¦ÌM), Listeria monocytogenes 21662(MIC=0.21 ¦ÌM), Listeria monocytogenes 21633(MIC=0.21 ¦ÌM), Bacillus cereus 63301(MIC=0.85 ¦ÌM), Micrococcus luteus 28001(MIC=0.43 ¦ÌM), Bacillus pumilus 63202(MIC=0.85 ¦ÌM), Pseudomonas fluorescens 21620(MIC=0.43 ¦ÌM), MRSA 43300(MIC=0.85 ¦ÌM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC=0.85 ¦ÌM), Escherichia coli 25922(MIC=1.70 ¦ÌM), Escherichia coli 35150(MIC=1.70 ¦ÌM), Salmonella paratyphi-A 20501(MIC=0.43 ¦ÌM), Salmonella paratyphi paratyphi-B 21495(MIC=0.85 ¦ÌM), Salmonella paratyphi paratyphi-C 21512(MIC=0.43 ¦ÌM), Shigella flexneri 51571(MIC=0.43 ¦ÌM), Salmonella choleraesuis 13312(MIC=1.70 ¦ÌM), Salmonella typhimurium 51005(MIC=6.81 ¦ÌM), Salmonella enteritidis 21527(MIC=6.81 ¦ÌM), Vibrio parahemolyticus 21617(MIC=1.70 ¦ÌM);##Fungi : Candida albicans 10231(MIC=3.40 ¦ÌM)"	[Ref.28002968] MHC10=27.22 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28002968] The cell viability of RAW264.7 cells induced by WRL3 is 98.31%, 95.21%, 92.96%, 90.70%, 89.30%, 89.01%, 76.90%, 48.45% and 40.73% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	28002968	J Med Chem.?2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.	"Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X"	Insights into the?Antimicrobial?Activity and Cytotoxicity of Engineered ¦Á-Helical?PeptideAmphiphiles.
DRAMP21185	WGRAFRRLVRRLARGLRR	18	WRL2 (Derived from leucocin A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix, beta sheet, turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=3.49 ¦ÌM), Staphylococcus aureus 1.160(MIC=1.74 ¦ÌM), Listeria monocytogenes 21662(MIC=1.74 ¦ÌM), Listeria monocytogenes 21633(MIC=1.74 ¦ÌM), Bacillus cereus 63301(MIC=55.78 ¦ÌM), Micrococcus luteus 28001(MIC=27.89 ¦ÌM), Bacillus pumilus 63202(MIC=55.78 ¦ÌM), Pseudomonas fluorescens 21620(MIC=55.78 ¦ÌM), MRSA 43300(MIC=6.97 ¦ÌM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC=6.97 ¦ÌM), Escherichia coli 25922(MIC=27.89 ¦ÌM), Escherichia coli 35150(MIC=13.94 ¦ÌM), Salmonella paratyphi-A 20501(MIC=3.49 ¦ÌM), Salmonella paratyphi paratyphi-B 21495(MIC=6.97 ¦ÌM), Salmonella paratyphi paratyphi-C 21512(MIC=3.49 ¦ÌM), Shigella flexneri 51571(MIC=3.49 ¦ÌM), Salmonella choleraesuis 13312(MIC=13.94 ¦ÌM), Salmonella typhimurium 51005(MIC=13.94 ¦ÌM), Salmonella enteritidis 21527(MIC>55.78 ¦ÌM), Vibrio parahemolyticus 21617(MIC=13.94 ¦ÌM);##Fungi : Candida albicans 10231(MIC=13.94 ¦ÌM)"	[Ref.28002968] MHC10>55.78 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28002968] The cell viability of RAW264.7 cells induced by WRL2 is 87.32%, 85.35%, 81.13%, 79.15%, 78.87%, 78.03%, 76.34%, 69.86% and 64.79% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	28002968	J Med Chem.?2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.	"Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X"	Insights into the?Antimicrobial?Activity and Cytotoxicity of Engineered ¦Á-Helical?PeptideAmphiphiles.
DRAMP21184	WGRAFRRGVRRLARGGRR	18	WR7 (Derived from leucocin A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix, beta sheet, turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=14.66 ¦ÌM), Staphylococcus aureus 1.160(MIC=7.33 ¦ÌM), Listeria monocytogenes 21662(MIC=7.33 ¦ÌM), Listeria monocytogenes 21633(MIC=7.33 ¦ÌM), Bacillus cereus 63301(MIC=14.66 ¦ÌM), Micrococcus luteus 28001(MIC=7.33 ¦ÌM), Bacillus pumilus 63202(MIC>58.64 ¦ÌM), Pseudomonas fluorescens 21620(MIC=29.32 ¦ÌM), MRSA 43300(MIC=14.66 ¦ÌM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC=3.67 ¦ÌM), Escherichia coli 25922(MIC=14.66 ¦ÌM), Escherichia coli 35150(MIC=29.32 ¦ÌM), Salmonella paratyphi-A 20501(MIC=7.33 ¦ÌM), Salmonella paratyphi paratyphi-B 21495(MIC=3.67 ¦ÌM), Salmonella paratyphi paratyphi-C 21512(MIC=7.33 ¦ÌM), Shigella flexneri 51571(MIC=7.33 ¦ÌM), Salmonella choleraesuis 13312(MIC=14.66 ¦ÌM), Salmonella typhimurium 51005(MIC>58.64 ¦ÌM), Salmonella enteritidis 21527(MIC>58.64 ¦ÌM), Vibrio parahemolyticus 21617(MIC=29.32 ¦ÌM);##Fungi : Candida albicans 10231(MIC=29.32 ¦ÌM)"	[Ref.28002968] MHC10>58.64 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28002968] The cell viability of RAW264.7 cells induced by WR7 is 97.46%, 94.65%, 89.01%, 82.25%, 81.41%, 80.85%, 78.59%, 76.06% and 74.80% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	28002968	J Med Chem.?2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.	"Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X"	Insights into the?Antimicrobial?Activity and Cytotoxicity of Engineered ¦Á-Helical?PeptideAmphiphiles.
DRAMP21183	WGRAFSRGVRRLARGGRG	18	WR5 (Derived from leucocin A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix, beta sheet, turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=31.77 ¦ÌM), Staphylococcus aureus 1.160(MIC=15.89 ¦ÌM), Listeria monocytogenes 21662(MIC=15.89 ¦ÌM), Listeria monocytogenes 21633(MIC=31.77 ¦ÌM), Bacillus cereus 63301(MIC>63.54 ¦ÌM), Micrococcus luteus 28001(MIC>63.54 ¦ÌM), Bacillus pumilus 63202(MIC>63.54 ¦ÌM), Pseudomonas fluorescens 21620(MIC>63.54 ¦ÌM), MRSA 43300(MIC>63.54 ¦ÌM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC=7.94 ¦ÌM), Escherichia coli 25922(MIC=31.77 ¦ÌM), Escherichia coli 35150(MIC=31.77 ¦ÌM), Salmonella paratyphi-A 20501(MIC=15.89 ¦ÌM), Salmonella paratyphi paratyphi-B 21495(MIC=15.89 ¦ÌM), Salmonella paratyphi paratyphi-C 21512(MIC=15.89 ¦ÌM), Shigella flexneri 51571(MIC=15.89 ¦ÌM), Salmonella choleraesuis 13312(MIC=15.89 ¦ÌM), Salmonella typhimurium 51005(MIC>63.54 ¦ÌM), Salmonella enteritidis 21527(MIC>63.54 ¦ÌM), Vibrio parahemolyticus 21617(MIC>63.54 ¦ÌM);##Fungi : Candida albicans 10231(MIC>63.54 ¦ÌM)"	[Ref.28002968] MHC10>63.54 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28002968] The cell viability of RAW264.7 cells induced by WR5 is 98.59%, 97.46%, 96.06%, 96.09%, 92.96%, 91.83%, 89.58%, 87.32% and 85.48% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	28002968	J Med Chem.?2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.	"Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X"	Insights into the?Antimicrobial?Activity and Cytotoxicity of Engineered ¦Á-Helical?PeptideAmphiphiles.
DRAMP21182	WGRAFSAGVHRLARGGRG	18	WR3 (Derived from leucocin A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix, beta sheet, turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>67.01 ¦ÌM), Staphylococcus aureus 1.160(MIC>67.01 ¦ÌM), Listeria monocytogenes 21662(MIC=33.50 ¦ÌM), Listeria monocytogenes 21633(MIC=67.01 ¦ÌM), Bacillus cereus 63301(MIC>67.01 ¦ÌM), Micrococcus luteus 28001(MIC>67.01 ¦ÌM), Bacillus pumilus 63202(MIC>67.01 ¦ÌM), Pseudomonas fluorescens 21620(MIC>67.01 ¦ÌM), MRSA 43300(MIC>67.01 ¦ÌM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC=16.75 ¦ÌM), Escherichia coli 25922(MIC>67.01 ¦ÌM), Escherichia coli 35150(MIC>67.01 ¦ÌM), Salmonella paratyphi-A 20501(MIC=33.50 ¦ÌM), Salmonella paratyphi paratyphi-B 21495(MIC>67.01 ¦ÌM), Salmonella paratyphi paratyphi-C 21512(MIC>67.01 ¦ÌM), Shigella flexneri 51571(MIC>67.01 ¦ÌM), Salmonella choleraesuis 13312(MIC=33.50 ¦ÌM), Salmonella typhimurium 51005(MIC>67.01 ¦ÌM), Salmonella enteritidis 21527(MIC>67.01 ¦ÌM), Vibrio parahemolyticus 21617(MIC>67.01 ¦ÌM);##Fungi : Candida albicans 10231(MIC>67.01 ¦ÌM)"	[Ref.28002968] MHC10>67.01 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28002968] The cell viability of RAW264.7 cells induced by WR3 is 100%, 98.87%, 92.11%, 90.42%, 90.42%, 88.45%, 87.61%, 87.89% and 87.22% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	28002968	J Med Chem.?2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.	"Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X"	Insights into the?Antimicrobial?Activity and Cytotoxicity of Engineered ¦Á-Helical?PeptideAmphiphiles.
DRAMP21181	WGRAFSAGVHRLANGGNG	18	WR1 (Derived from leucocin A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix, beta sheet, turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>70.09s ¦ÌM), Staphylococcus aureus 1.160(MIC=70.09 ¦ÌM), Listeria monocytogenes 21662(MIC>70.09 ¦ÌM), Listeria monocytogenes 21633(MIC>70.09 ¦ÌM), Bacillus cereus 63301(MIC>70.09 ¦ÌM), Micrococcus luteus 28001(MIC>70.09 ¦ÌM), Bacillus pumilus 63202(MIC>70.09 ¦ÌM), Pseudomonas fluorescens 21620(MIC>70.09 ¦ÌM), MRSA 43300(MIC>70.09 ¦ÌM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC>70.09 ¦ÌM), Escherichia coli 25922(MIC>70.09 ¦ÌM), Escherichia coli 35150(MIC>70.09 ¦ÌM), Salmonella paratyphi-A 20501(MIC>70.09 ¦ÌM), Salmonella paratyphi paratyphi-B 21495(MIC>70.09 ¦ÌM), Salmonella paratyphi paratyphi-C 21512(MIC>70.09 ¦ÌM), Shigella flexneri 51571(MIC>70.09 ¦ÌM), Salmonella choleraesuis 13312(MIC>70.09 ¦ÌM), Salmonella typhimurium 51005(MIC>70.09 ¦ÌM), Salmonella enteritidis 21527(MIC>70.09 ¦ÌM), Vibrio parahemolyticus 21617(MIC>70.09 ¦ÌM);##Fungi : Candida albicans 10231(MIC>70.09 ¦ÌM)"	[Ref.28002968] MHC10>70.09 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28002968] The cell viability of RAW264.7 cells induced by WR1 is 99.44%, 96.62%, 95.21%, 94.08%, 92.96%, 92.99%, 92.68%, 87.04% and 77.58% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	28002968	J Med Chem.?2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.	"Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X"	Insights into the?Antimicrobial?Activity and Cytotoxicity of Engineered ¦Á-Helical?PeptideAmphiphiles.
DRAMP21180	WGEAFSAGVHRLANGGNG	18	WG18 (Derived from leucocin A)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"Random coil, alpha helix, beta sheet, turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.28002968] Gram-positive bacteria : Staphylococcus aureus 29213(MIC>71.15 ¦ÌM), Staphylococcus aureus 1.160(MIC>71.15 ¦ÌM), Listeria monocytogenes 21662(MIC>71.15 ¦ÌM), Listeria monocytogenes 21633(MIC>71.15 ¦ÌM), Bacillus cereus 63301(MIC>71.15 ¦ÌM), Micrococcus luteus 28001(MIC>71.15 ¦ÌM), Bacillus pumilus 63202(MIC>71.15 ¦ÌM), Pseudomonas fluorescens 21620(MIC>71.15 ¦ÌM), MRSA 43300(MIC>71.15 ¦ÌM);##Gram-negative bacteria : Escherichia coli O157 : H7 21530(MIC>71.15 ¦ÌM), Escherichia coli 25922(MIC>71.15 ¦ÌM), Escherichia coli 35150(MIC>71.15 ¦ÌM), Salmonella paratyphi-A 20501(MIC>71.15 ¦ÌM), Salmonella paratyphi paratyphi-B 21495(MIC>71.15 ¦ÌM), Salmonella paratyphi paratyphi-C 21512(MIC>71.15 ¦ÌM), Shigella flexneri 51571(MIC>71.15 ¦ÌM), Salmonella choleraesuis 13312(MIC>71.15 ¦ÌM), Salmonella typhimurium 51005(MIC>71.15 ¦ÌM), Salmonella enteritidis 21527(MIC>71.15 ¦ÌM), Vibrio parahemolyticus 21617(MIC>71.15 ¦ÌM);##Fungi : Candida albicans 10231(MIC>71.15 ¦ÌM)"	[Ref.28002968] MHC10>71.15 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28002968] The cell viability of RAW264.7 cells induced by WG18 is 98.87%, 94.93%, 93.52%, 90.14%, 85.35%, 83.10%, 80.56%, 75.77% and 73.62% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	28002968	J Med Chem.?2016 Dec 22;59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.	"Ma Z, Yang J, Han J, Gao L, Liu H, Lu Z, Zhao H, Bie X"	Insights into the?Antimicrobial?Activity and Cytotoxicity of Engineered ¦Á-Helical?PeptideAmphiphiles.
DRAMP21179	GILSSLWKKPKKIIAK	16	HYL-26 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC>100 ¦ÌM), Staphylococcus epidermidis(MIC>100 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC>100¦ÌM), Pseudomonas aeruginosa 5482(MIC=98 ¦ÌM);##Fungi : Candida albicans(MIC>100 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21178	GILSSLWKKLKKWIAK	16	HYL-25 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=2.5 ¦ÌM), Staphylococcus epidermidis(MIC=1.6 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=2.5 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=13 ¦ÌM);##Fungi : Candida albicans(MIC=13 ¦ÌM)"	[Ref.26998557] LC50=57 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21177	GILSSLLKKLKKWIAK	16	HYL-24 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=8 ¦ÌM), Staphylococcus epidermidis(MIC=1.6 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=4 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=8 ¦ÌM);##Fungi : Candida albicans(MIC=16 ¦ÌM)"	[Ref.26998557] LC50=115 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21176	GILSSLLKKWKKIIAK	16	HYL-23 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=20 ¦ÌM), Staphylococcus epidermidis(MIC=2.7 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=7.5 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=5 ¦ÌM);##Fungi : Candida albicans(MIC=11 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21175	GKLSSLWKKLKKIIAK	16	HYL-22 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=26 ¦ÌM), Staphylococcus epidermidis(MIC=2.5 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=20 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=6.8 ¦ÌM);##Fungi : Candida albicans(MIC=34 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21174	gilsslwkklkkiiak	16	HYL-21 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=6.3 ¦ÌM), Staphylococcus epidermidis(MIC=1.7 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=5 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=6.7 ¦ÌM);##Fungi : Candida albicans(MIC=8 ¦ÌM)"	[Ref.26998557] LC50=191 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	D	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21173	GILSSLWKKLKKIIAK	16	HYL-20 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=5.3 ¦ÌM), Staphylococcus epidermidis(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=3.4 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=5.3 ¦ÌM);##Fungi : Candida albicans(MIC=11 ¦ÌM)"	[Ref.26998557] LC50=197 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21172	GILSSWLKKLKKIIAK	16	HYL-19 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=16 ¦ÌM), Staphylococcus epidermidis(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=11 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=4 ¦ÌM);##Fungi : Candida albicans(MIC=17 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21168	GILKSLLKKLKKIIAK	16	HYL-15 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=17 ¦ÌM), Staphylococcus epidermidis(MIC=2.2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=10 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=5 ¦ÌM);##Fungi : Candida albicans(MIC=24 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21169	GILSKLLKKLKKIIAK	16	HYL-16 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=23 ¦ÌM), Staphylococcus epidermidis(MIC=1.8 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=18 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=4.5 ¦ÌM);##Fungi : Candida albicans(MIC=45 ¦ÌM)"	[Ref.26998557] LC50>400 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21170	kILSSLLKKLKKIIAK	16	HYL-17 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=32 ¦ÌM), Staphylococcus epidermidis(MIC=1.4 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=16 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=5 ¦ÌM);##Fungi : Candida albicans(MIC=25 ¦ÌM)"	[Ref.26998557] LC50=364 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	Mixed(1 is D)	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21171	GIWSSLLKKLKKIIAK	16	HYL-18 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=20 ¦ÌM), Staphylococcus epidermidis(MIC=1.5 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=1.6 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=6.3 ¦ÌM);##Fungi : Candida albicans(MIC=16 ¦ÌM)"	[Ref.26998557] LC50=165 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21243	GFFALIPKIISSPLFKTLLSAVGSALS	27	pardaxin-6 (GE-6) (Derived from pardaxin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.23598079] Gram-positive bacteria : Micrococcus luteus(MIC=25 mg/L), Staphylococcus aureus(MIC=50 mg/L), Streptococcus pneumoniae(MIC=50 mg/L), Streptococcus agalactiae(MIC=50 mg/L), Staphylococcus sp.(MIC=6.25 mg/L);##Gram-negative bacteria : Grouper Vibrio alginolyticus(MIC=12.5 mg/L), Vibrio harveyi(MIC=12.5 mg/L), Vibrio vulnificus(MIC=50 mg/L)"	"[Ref.23598079] 8% hemolysis at 12.5 mg/L , 29% hemolysis at 25 mg/L , 38% hemolysis at 50 mg/L , 57.5% hemolysis at 100 mg/L , 99% hemolysis at 200 mg/L , 98% hemolysis at 400 mg/L against sheep red blood cells"	Linear	Free	Free	None	L	[Ref.23598079] No cytotoxicity information found.	Not found	23598079	Peptides.?2013 Jun;44:139-48. doi: 10.1016/j.peptides.2013.04.004.	"Lin MC, Hui CF, Chen JY, Wu JL"	Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus.
DRAMP21242	FIFHIIKGLFHAGKMI	16	Epinecidin-8 (Derived from Epinecidin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.23598079] Gram-positive bacteria : Staphylococcus aureus(MIC=6.25 mg/L), Staphylococcus sp.(MIC=12.5 mg/L);##Gram-negative bacteria : Grouper Vibrio alginolyticus(MIC=12.5 mg/L), Vibrio harveyi(MIC=6.25 mg/L)"	"[Ref.23598079] 0% hemolysis at 50 mg/L , 10% hemolysis at 100 mg/L , 20% hemolysis at 200 mg/L , 50% hemolysis at 400 mg/L against sheep red blood cells"	Linear	Free	Free	None	L	[Ref.23598079] No cytotoxicity information found.	Not found	23598079	Peptides.?2013 Jun;44:139-48. doi: 10.1016/j.peptides.2013.04.004.	"Lin MC, Hui CF, Chen JY, Wu JL"	Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus.
DRAMP21241	GFIFHIIKGLFHAGKMIHGLV	21	Epinecidin-1 (Derived from Epinecidin)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.23598079] Gram-positive bacteria : Micrococcus luteus(MIC=6.25 mg/L), Staphylococcus aureus(MIC=50 mg/L), Streptococcus pneumoniae(MIC=50 mg/L), Streptococcus agalactiae(MIC>=100 mg/L), Staphylococcus sp.(MIC=6.25 mg/L);##Gram-negative bacteria : Grouper Vibrio alginolyticus(MIC=6.25 mg/L), Vibrio harveyi(MIC=6.25 mg/L), Vibrio vulnificus(MIC=50 mg/L)"	"[Ref.23598079] 0% hemolysis at 25 mg/L , 10% hemolysis at 50 mg/L , 15% hemolysis at 100 mg/L , 30% hemolysis at 200 mg/L , 50% hemolysis at 400 mg/L against sheep red blood cells"	Linear	Free	Free	None	L	[Ref.23598079] No cytotoxicity information found.	Not found	23598079	Peptides.?2013 Jun;44:139-48. doi: 10.1016/j.peptides.2013.04.004.	"Lin MC, Hui CF, Chen JY, Wu JL"	Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus.
DRAMP21240	WKRWVRRWKRWLR	13	FK13-a7 (Derived from FK13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28161291] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28161291] HC50=138.0 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a7 is 100.2%, 112.8%, 97.0%, 95.1%, 83.4% and 83.8% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 ¦ÌM.## The cell viablity of human keratinocyte HaCaT induced by FK1"	Not found	28161291	Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.	"Rajasekaran G,?Kim EY,?Shin SY"	"LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity."
DRAMP21239	WKRWVQRWKRWLR	13	FK13-a6 (Derived from FK13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28161291] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=8 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28161291] HC50=167.5 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a6 is 91.3%, 94.6%, 103.0%, 96.6%, 61.9% and 28.7% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 ¦ÌM.## The cell viablity of human keratinocyte HaCaT induced by FK13"	Not found	28161291	Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.	"Rajasekaran G,?Kim EY,?Shin SY"	"LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity."
DRAMP21238	WKRWVQRWKRFLR	13	FK13-a5 (Derived from FK13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28161291] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28161291] HC50=230.0 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a5 is 105.3%, 103.9%, 97.1%, 94.0%, 47.5% and 44.2% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 ¦ÌM.## The cell viablity of human keratinocyte HaCaT induced by FK1"	Not found	28161291	Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.	"Rajasekaran G,?Kim EY,?Shin SY"	"LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity."
DRAMP21237	FKRWVQRWKRFLR	13	FK13-a4 (Derived from FK13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28161291] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28161291] HC50>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a4 is 94.0%, 95.7%, 108.7%, 93.2%, 52.8% and 10.6% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 ¦ÌM.## The cell viablity of human keratinocyte HaCaT induced by FK13"	Not found	28161291	Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.	"Rajasekaran G,?Kim EY,?Shin SY"	"LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity."
DRAMP21236	WKRIVRRIWRWLR	13	FK13-a3 (Derived from FK13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28161291] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.28161291] HC50=12.5 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a3 is 102.3%, 112.1%, 104.5%, 103.8%, 74.3% and 70.2% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 ¦ÌM.## The cell viablity of human keratinocyte HaCaT induced by F"	Not found	28161291	Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.	"Rajasekaran G,?Kim EY,?Shin SY"	"LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity."
DRAMP21235	WKRIVRWIKRWLR	13	FK13-a2 (Derived from FK13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28161291] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=4 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.28161291] HC50=14.0 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a2 is 104.5%, 101.7%, 100.4%, 77.0%, 58.9% and 15.8% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 ¦ÌM.## The cell viablity of human keratinocyte HaCaT induced by FK"	Not found	28161291	Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.	"Rajasekaran G,?Kim EY,?Shin SY"	"LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity."
DRAMP21167	gilssllkklkkiiak	16	HYL-13 (Derived from HYL)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.26998557] Gram-positive bacteria : Staphylococcus aureus 6271(MIC=5.7 ¦ÌM), Staphylococcus epidermidis(MIC=3.2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=4.5 ¦ÌM), Pseudomonas aeruginosa 5482(MIC=4.5 ¦ÌM);##Fungi : Candida albicans(MIC=9 ¦ÌM)"	[Ref.26998557] LC50=333 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	D	[Ref.26998557] No cytotoxicity information found.	Not found	26998557	J Nat Prod.?2016 Apr 22;79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.	"Ne?uta O, Hexnerov¨¢ R, Bud¨§?¨ªnsk? M, Slaninov¨¢ J, Bedn¨¢rov¨¢ L, Hadravov¨¢ R, Straka J, Veverka V, ?e?ovsk? V"	Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
DRAMP21234	WKRIVRRIKRWLR	13	FK13-a1 (Derived from FK13)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.28161291] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus(KCTC1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa(KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium(KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.28161291] HC50>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a1 is 95.5%, 107.5%, 100.2%, 96.2%, 44.9% and 37.4% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 ¦ÌM.## The cell viablity of human keratinocyte HaCaT induced by FK1"	Not found	28161291	Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.	"Rajasekaran G,?Kim EY,?Shin SY"	"LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity."
DRAMP21233	GIMDTVKNAAKNLAGQLLDKLK	22	R2PLx-22 (Derived from R2PLx)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	The CD spectra of both peptides shows the pattern of random coil in aqueous solution and a typical ¦Á-helix CD spectra in 50% of TFE solution.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.30279210] Gram-positive bacteria : Staphylococcus aureus(NCTC 10788)(MIC=256 ¦ÌM, MBC=256 ¦ÌM), MRSA (ATCC 12493)(MIC>512 ¦ÌM, MBC>512 ¦ÌM), Enterococcus faecalis(NCTC 12697)(MIC>512 ¦ÌM, MBC>512 ¦ÌM);##Gram-negative bacteria : Escherichia coli(NCTC 10418)(MIC=128 ¦ÌM, MBC=256 ¦ÌM), Pseudomonas aeruginosa(ATCC 27853)(MIC= ¦ÌM, MBC= ¦ÌM);##Fungi : Candida albicans(NCTC 1467)(MIC=512 ¦ÌM, MBC>512 ¦ÌM)"	"[Ref.30279210] 3% hemolysis at 1 ¦ÌM , 4% hemolysis at 2 ¦ÌM , 1% hemolysis at 4 ¦ÌM , 0% hemolysis at 8 ¦ÌM , 2% hemolysis at 16 ¦ÌM , 0% hemolysis at 32 ¦ÌM , 0% hemolysis at 128 ¦ÌM , 3% hemolysis at 256 ¦ÌM , 13% hemolysis at 512 ¦ÌM against human red blood cells"	Linear	Free	Free	None	L	[Ref.30279210] No cytotoxicity information found	Not found	30279210	Biosci Rep.?2018 Nov 9;38(6). pii: BSR20180710. doi: 10.1042/BSR20180710.	"Chen X,?Zhang L,?Ma C,?Zhang Y,?Xi X,?Wang L,?Zhou M,?Burrows JF,?Chen T"	"A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells."
DRAMP21244	FLSLIPKLVKKIIKAFK	17	TsAP-S1 (Derived from TsAP-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Anticancer against H157, H838, MCF-7, PC3 and U251-MG"	"[Ref.23770440] Gram-positive bacteria : Staphylococcus aureus(MIC=2.5 ¦ÌM, MBC=20 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=5 ¦ÌM, MBC=20 ¦ÌM);##Fungi : Candida albicans(MIC=2.5 ¦ÌM, MBC=5 ¦ÌM)"	"[Ref.23770440] 30% hemolysis at 5 ¦ÌM , 85% hemolysis at 10 ¦ÌM , 100% hemolysis at 20 ¦ÌM against horse red blood cells"	Linear	Free	Amidation	None	L	[Ref.23770440] No cytotoxicity information found.	Not found	23770440	Biochimie.?2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.	"Guo X,?Ma C,?Du Q,?Wei R,?Wang L,?Zhou M,?Chen T,?Shaw C"	"Two?peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their?antimicrobial?and anticancer activities."
DRAMP21245	FLGMIPKLIKKLIKAFK	17	TsAP-S2 (Derived from TsAP-2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Alpha helix	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Anticancer against H157, H838, MCF-7, PC3 and U252-MG"	"[Ref.23770440] Gram-positive bacteria : Staphylococcus aureus(MIC=5 ¦ÌM, MBC=20 ¦ÌM);##Gram-negative bacteria : Escherichia coli(MIC=5 ¦ÌM, MBC=40 ¦ÌM);##Fungi : Candida albicans(MIC=2.5 ¦ÌM, MBC=10 ¦ÌM)"	"[Ref.23770440] 30% hemolysis at 5 ¦ÌM , 85% hemolysis at 10 ¦ÌM , 100% hemolysis at 20 ¦ÌM against horse red blood cells"	Linear	Free	Amidation	None	L	[Ref.23770440] No cytotoxicity information found.	Not found	23770440	Biochimie.?2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.	"Guo X,?Ma C,?Du Q,?Wei R,?Wang L,?Zhou M,?Chen T,?Shaw C"	"Two?peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their?antimicrobial?and anticancer activities."
DRAMP21246	KKWRWWLKALAKK	13	pEM-2 (Derived from the venom of the snake Bothrops asper)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=5.3 ¡À 2.3 mg/L, MBC=6.7 ¡À 2.3 mg/L), Enterococcus faecalis isolates(MIC=6.7 ¡À 2.3 mg/L, MBC=8.0 ¡À 0.0 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=4.0 ¡À 3.5 mg/L, MBC=4.0 ¡À 3.5 mg/L), Acinetobacter baumannii isolates(MIC=4.0 ¡À 0.0 mg/L, MBC=5.3 ¡À 2.3 mg/L)"	"[Ref.27591703] 0% hemolysis at 2 ¦Ìg/ml , 5% hemolysis at 4 ¦Ìg/ml , 15% hemolysis at 8 ¦Ìg/ml , 55% hemolysis at 16 ¦Ìg/ml , 87% hemolysis at 32 ¦Ìg/ml , 92% hemolysis at 64 ¦Ìg/ml against human red blood cells; 0% hemolysis at 16 ¦Ìg/ml , 2.5% hemolysis at 32 ¦Ìg/ml , 10% hemolysis at 64 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27591703] The cell viability of HEK293 cells induced by PV is 99.1%, 99.1%, 98.3%, 94.8%, 93.9%, 87.5% and 84.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦Ìg/mL within 24h."	Not found	27591703	Chem Biol Drug Des.?2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864.	"Memariani H,?Shahbazzadeh D,?Ranjbar R,?Behdani M,?Memariani M,?Pooshang Bagheri K"	"Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B."
DRAMP21247	KKWRWWLKALAKKLL	15	PV (Derived from pEM-2 and MP-VT1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=0.5 ¡À 0.0 mg/L, MBC=0.5 ¡À 0.0 mg/L), Enterococcus faecalis isolates(MIC=0.7 ¡À 0.3 mg/L, MBC=0.8 ¡À 0.3 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=1.2 ¡À 0.8 mg/L, MBC=1.3 ¡À 0.6 mg/L), Acinetobacter baumannii isolates(MIC=0.4 ¡À 0.1 mg/L, MBC=0.5 ¡À 0.0 mg/L)"	"[Ref.27591703] 0% hemolysis at 32 ¦Ìg/ml , 5% hemolysis at 64 ¦Ìg/ml against human red blood cells; 0% hemolysis at 32 ¦Ìg/ml , 8% hemolysis at 64 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27591703] The cell viability of HEK293 cells induced by PV is 98.8%, 97.4%, 85.8%, 56.2%, 22.8%, 12.2% and 2.3% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦Ìg/mL within 24h."	Not found	27591703	Chem Biol Drug Des.?2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864.	"Memariani H,?Shahbazzadeh D,?Ranjbar R,?Behdani M,?Memariani M,?Pooshang Bagheri K"	"Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B."
DRAMP21248	LKLKAIAALAKKKW	14	BVP (Derived from pEM-2 and MP-VT1 and MP-B)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=24.0 ¡À 13.9 mg/L, MBC=37.3 ¡À 24.4 mg/L), Enterococcus faecalis isolates(MIC=12.0 ¡À 6.9 mg/L, MBC=18.7 ¡À 12.2 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=16.0 ¡À 13.9 mg/L, MBC=18.7 ¡À 12.2 mg/L), Acinetobacter baumannii isolates(MIC=8.0 ¡À 0.0 mg/L, MBC=10.7 ¡À 4.6 mg/L)"	"[Ref.27591703] 0% hemolysis at 64 ¦Ìg/ml against human red blood cells; 0% hemolysis at 16 ¦Ìg/ml , 2.5% hemolysis at 32 ¦Ìg/ml , 10% hemolysis at 64 ¦Ìg/ml against sheep red blood cells"	Linear	Free	Amidation	None	L	"[Ref.27591703] The cell viability of HEK293 cells induced by PV is 98.9%, 95.4%, 89.7%, 83.4%, 83.1%, 73.7% and 71.5% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦Ìg/mL within 24h."	Not found	27591703	Chem Biol Drug Des.?2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864.	"Memariani H,?Shahbazzadeh D,?Ranjbar R,?Behdani M,?Memariani M,?Pooshang Bagheri K"	"Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B."
DRAMP21249	KKWRKLLKWLAKK	13	PVP (Derived from MP-B and MP-VT1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=4.3 ¡À 3.5 mg/L, MBC=6.0 ¡À 3.5 mg/L), Enterococcus faecalis isolates(MIC=2.7 ¡À 1.2 mg/L, MBC=3.3 ¡À 1.2 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=1.3 ¡À 0.6 mg/L, MBC=1.7 ¡À 0.6 mg/L), Acinetobacter baumannii isolates(MIC=2.3 ¡À 1.5 mg/L, MBC=2.7 ¡À 1.2 mg/L)"	[Ref.27591703] 0% hemolysis at 64 ¦Ìg/ml against human red blood cells; 0% hemolysis at 64 ¦Ìg/ml against sheep red blood cells	Linear	Free	Amidation	None	L	"[Ref.27591703] The cell viability of HEK293 cells induced by PV is 98.8%, 100%, 97.3%, 94.2%, 92.3%, 89.2% and 84.6% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦Ìg/mL within 24h."	Not found	27591703	Chem Biol Drug Des.?2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864.	"Memariani H,?Shahbazzadeh D,?Ranjbar R,?Behdani M,?Memariani M,?Pooshang Bagheri K"	"Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B."
DRAMP21250	KKWRKLLKKLKKLL	14	PV3 (Derived from pEM-2 and MP-VT1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=2.0 ¡À 1.7 mg/L, MBC=2.3 ¡À 1.5 mg/L), Enterococcus faecalis isolates(MIC=1.2 ¡À 0.8 mg/L, MBC=1.3 ¡À 0.6 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=1.0 ¡À 0.0 mg/L, MBC=1.3 ¡À 0.6 mg/L), Acinetobacter baumannii isolates(MIC=1.0 ¡À 0.0 mg/L, MBC=1.7 ¡À 0.6 mg/L)"	[Ref.27591703] 0% hemolysis at 64 ¦Ìg/ml against human red blood cells; 10% hemolysis at 64 ¦Ìg/ml against sheep red blood cells	Linear	Free	Amidation	None	L	"[Ref.27591703] The cell viability of HEK293 cells induced by PV is 98.8%, 99.2%, 95.4%, 93.8%, 91.9%, 77.3% and 55.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦Ìg/mL within 24h."	Not found	27591703	Chem Biol Drug Des.?2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864.	"Memariani H,?Shahbazzadeh D,?Ranjbar R,?Behdani M,?Memariani M,?Pooshang Bagheri K"	"Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B."
DRAMP21253	FLFKLIPKAIKGLVKAIRK	19	AaeAP1a (Derived from AaeAP1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.25626077] Gram-positive bacteria : Staphylococcus aureus(MIC=4 mg/L, MBC=32 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=16 mg/L, MBC=32 mg/L);##Fungi : Candida albicans(MIC=4 mg/L, MBC=16 mg/L)"	[Ref.25626077] 100% hemolysis at 32 ¦Ìg/ml against horse red blood cells	Linear	Free	Amidation	None	L	[Ref.25626077] No cytotoxicity information found.	Not found	25626077	Toxins (Basel).?2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.	"Du Q,?Hou X,?Wang L,?Zhang Y,?Xi X,?Wang H,?Zhou M,?Duan J,?Wei M,?Chen T,?Shaw C"	"AaeAP1 and AaeAP2: novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAs and engineering of analogues with enhanced antimicrobial and anticancer activities."
DRAMP21254	FLFKLIPKVIKGLVKAIRK	19	AaeAP2a (Derived from AaeAP2)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans	"[Ref.25626077] Gram-positive bacteria : Staphylococcus aureus(MIC=4 mg/L, MBC=32 mg/L);##Gram-negative bacteria : Escherichia coli(MIC=16 mg/L, MBC=32 mg/L);##Fungi : Candida albicans(MIC=4 mg/L, MBC=16 mg/L)"	[Ref.25626077] 100% hemolysis at 64 ¦Ìg/ml against horse red blood cells	Linear	Free	Amidation	None	L	[Ref.25626077] No cytotoxicity information found.	Not found	25626077	Toxins (Basel).?2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.	"Du Q,?Hou X,?Wang L,?Zhang Y,?Xi X,?Wang H,?Zhou M,?Duan J,?Wei M,?Chen T,?Shaw C"	"AaeAP1 and AaeAP2: novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAs and engineering of analogues with enhanced antimicrobial and anticancer activities."
DRAMP21255	WLSKTAKKL	9	WL1 (Derived from CP-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unordered conformation	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.29266746] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 ¦ÌM), Staphylococcus aureus ATCC 43300(MIC>128 ¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC>128 ¦ÌM), Bacillus subtilis CMCC 63501(MIC>128 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC>128 ¦ÌM), Escherichia coli UB1005(MIC>128 ¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC>128 ¦ÌM), Salmonella typhimurium ATCC 7731(MIC>128 ¦ÌM), Salmonella pullorum C79-13(MIC>128 ¦ÌM)"	[Ref.29266746] MHC5>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.29266746] The cell viability of IPEC-J2 cells induced by WL1 is 99.2%, 89.8%, 86.2%, 90.8%, 87.8%, 94.3% and 76.5% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. The cell viability of IPEC-J2 cells induced by the control Melittin is 7"	Not found	29266746	Chem Biol Drug Des.?2018 May;91(5):1017-1029. doi: 10.1111/cbdd.13165.	"Dong N,?Wang Z,?Chou S,?Zhang L,?Shan A,?Jiang J"	Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1.
DRAMP21256	WLSKTAKKLWLSKTAKKL	18	WL2 (Derived from CP-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.29266746] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC=128 ¦ÌM), Staphylococcus aureus ATCC 43300(MIC=128 ¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=128 ¦ÌM), Bacillus subtilis CMCC 63501(MIC=64 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC=8 ¦ÌM), Escherichia coli UB1005(MIC=8 ¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC=16 ¦ÌM), Salmonella typhimurium ATCC 7731(MIC=32 ¦ÌM), Salmonella pullorum C79-13(MIC=16 ¦ÌM)"	[Ref.29266746] MHC5>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.29266746] The cell viability of IPEC-J2 cells induced by WL2 is 99.0%, 95.0%, 89%, 89.8%, 85.2%, 86.8% and 75.1% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. The cell viability of IPEC-J2 cells induced by the control Melittin is 77."	Not found	29266746	Chem Biol Drug Des.?2018 May;91(5):1017-1029. doi: 10.1111/cbdd.13165.	"Dong N,?Wang Z,?Chou S,?Zhang L,?Shan A,?Jiang J"	Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1.
DRAMP21257	WLSKTAKKLWLSKTAKKLWLSKTAKKL	27	WL3 (Derived from CP-1)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Random coil, alpha helix"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.29266746] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC=32 ¦ÌM), Staphylococcus aureus ATCC 43300(MIC=32 ¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=32 ¦ÌM), Bacillus subtilis CMCC 63501(MIC=8 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC=2 ¦ÌM), Escherichia coli UB1005(MIC=2 ¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC=2 ¦ÌM), Salmonella typhimurium ATCC 7731(MIC=8 ¦ÌM), Salmonella pullorum C79-13(MIC=2 ¦ÌM)"	[Ref.29266746] MHC5>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.29266746] The cell viability of IPEC-J2 cells induced by WL3 is 97.0%, 100.4%, 91.4%, 91.5%, 87.2%, 86.7% and 78.7% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. The cell viability of IPEC-J2 cells induced by the control Melittin is "	Not found	29266746	Chem Biol Drug Des.?2018 May;91(5):1017-1029. doi: 10.1111/cbdd.13165.	"Dong N,?Wang Z,?Chou S,?Zhang L,?Shan A,?Jiang J"	Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1.
DRAMP21258	SWLSKTAKKLENSAKKRISEGIAIAIQGGPR	31	"Cecropin P1 (CP-1) (nematodes, animals)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	2N92 resolved by NMR	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.29266746] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 ¦ÌM), Staphylococcus aureus ATCC 43300(MIC>128 ¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC>128 ¦ÌM), Bacillus subtilis CMCC 63501(MIC=1 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC=0.5 ¦ÌM), Escherichia coli UB1005(MIC=0.5 ¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC>128 ¦ÌM), Salmonella typhimurium ATCC 7731(MIC=2 ¦ÌM), Salmonella pullorum C79-13(MIC=0.5 ¦ÌM)"	[Ref.29266746] MHC5>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.29266746] The cell viability of IPEC-J2 cells induced by CP-1 is 87.9%, 100.4%, 93.5%, 88.5%, 91.8%, 84.2% and 86.3% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. The cell viability of IPEC-J2 cells induced by the control Melittin is"	Not found	29266746	Chem Biol Drug Des.?2018 May;91(5):1017-1029. doi: 10.1111/cbdd.13165.	"Dong N,?Wang Z,?Chou S,?Zhang L,?Shan A,?Jiang J"	Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1.
DRAMP21259	MDSFQKIEKIGEGTYGVVYKAKDKVSGRLVALKKIRLENESEGVPSTA	48	"Scolopendin 1 (Centipedes, Arthropoda, Animals)"	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Not found	Not found	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Candida parapsilosis, Trichosporon beigelii"	"[Ref.25209888] Gram-positive bacteria : Staphylococcus aureus ATCC 25923(MIC=5.0 ¡À 4.3 ¦ÌM), Enterococcus faecium ATCC 19434(MIC=10.0 ¡À 8.7 ¦ÌM);##Gram-negative bacteria : Escherichia coli O-157 ATCC 43895(MIC=5.0 ¡À 4.3 ¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC= 5.0 ¡À 4.3 ¦ÌM);##Fungi : Candida albicans ATCC 90028(MIC=10.0 ¡À 8.7 ¦ÌM), Candida parapsilosis ATCC 22019(MIC= 10.0 ¡À 8.7 ¦ÌM), Trichosporon beigelii KCTC 7707(MIC=20.0 ¡À 17.3 ¦ÌM)"	[Ref.25209888] 0% hemolysis at 80 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.25209888] No cytotoxicity information found	Not found	25209888	Insect Mol Biol.?2014 Dec;23(6):788-99. doi: 10.1111/imb.12124.	"Choi H,?Hwang JS,?Lee DG"	"Identification of a novel antimicrobial peptide, scolopendin 1, derived from centipede Scolopendra subspinipes mutilans and its antifungal mechanism."
DRAMP21260	AAKAAAKAAAKAA	13	KL0A10 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Uncertain antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.26385363] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 ¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC>128 ¦ÌM), Streptococcus faecalis ATCC 29212(MIC>128 ¦ÌM), Bacillus subtilis CMCC 63501(MIC>128 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC>128 ¦ÌM), Escherichia coli K88(MIC>128 ¦ÌM), Escherichia coli CVCC 1515(MIC>128 ¦ÌM), Escherichia coli UB1005(MIC>128 ¦ÌM), Bacterium pyocyaneum ATCC 27853(MIC>128 ¦ÌM), Salmonella typhimurium ATCC 14028(MIC>128 ¦ÌM), Salmonella pullorum C79¨C13(MIC>128 ¦ÌM)"	[Ref.26385363] MHC5>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26385363] The cell viability of HEK293 cells induced by KL0A10 is 103.9%, 110%, 110.6%, 107.8%, 110.3%, 110.1%, 107.2% and 106.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. The cell viability of HEK293 cells induced by control M"	Not found	26385363	Amino Acids.?2016 Feb;48(2):403-17. doi: 10.1007/s00726-015-2094-y.	"Li W, Tan T,?Xu W,?Xu L,?Dong N,?Ma D,?Shan A"	Rational design of mirror-like peptides with alanine regulation.
DRAMP21261	LLKAAAKAAAKLL	13	KL4A6 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26385363] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 ¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=128 ¦ÌM), Streptococcus faecalis ATCC 29212(MIC=16 ¦ÌM), Bacillus subtilis CMCC 63501(MIC=32 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC=2 ¦ÌM), Escherichia coli K88(MIC=32 ¦ÌM), Escherichia coli CVCC 1515(MIC=32 ¦ÌM), Escherichia coli UB1005(MIC=32 ¦ÌM), Bacterium pyocyaneum ATCC 27853(MIC>128 ¦ÌM), Salmonella typhimurium ATCC 14028(MIC=128 ¦ÌM), Salmonella pullorum C79¨C13(MIC>128 ¦ÌM)"	[Ref.26385363] MHC5>256 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26385363] The cell viability of HEK293 cells induced by KL4A6 is 107.8%, 108.3%, 104.4%, 104.7%, 105.6%, 100%, 94.4% and 96.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. The cell viability of HEK293 cells induced by control Meli"	Not found	26385363	Amino Acids.?2016 Feb;48(2):403-17. doi: 10.1007/s00726-015-2094-y.	"Li W, Tan T,?Xu W,?Xu L,?Dong N,?Ma D,?Shan A"	Rational design of mirror-like peptides with alanine regulation.
DRAMP21262	AAKLLLKLLLKAA	13	KL6A4 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26385363] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC=32 ¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=16 ¦ÌM), Streptococcus faecalis ATCC 29212(MIC=16 ¦ÌM), Bacillus subtilis CMCC 63501(MIC=16 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC=1 ¦ÌM), Escherichia coli K88(MIC=16 ¦ÌM), Escherichia coli CVCC 1515(MIC=16 ¦ÌM), Escherichia coli UB1005(MIC=32 ¦ÌM), Bacterium pyocyaneum ATCC 27853(MIC>128 ¦ÌM), Salmonella typhimurium ATCC 14028(MIC>128 ¦ÌM), Salmonella pullorum C79¨C13(MIC>128 ¦ÌM)"	[Ref.26385363] MHC5=8 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26385363] The cell viability of HEK293 cells induced by KL6A4 is 102.8%, 109.4%, 103.9%, 109.4%, 105.3%, 90.6%,  83.1% and 81.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. The cell viability of HEK293 cells induced by control Me"	Not found	26385363	Amino Acids.?2016 Feb;48(2):403-17. doi: 10.1007/s00726-015-2094-y.	"Li W, Tan T,?Xu W,?Xu L,?Dong N,?Ma D,?Shan A"	Rational design of mirror-like peptides with alanine regulation.
DRAMP21263	LLKLLLKLLLKLL	13	KL10A0 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Uncertain antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.26385363] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 ¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC>128 ¦ÌM), Streptococcus faecalis ATCC 29212(MIC>128 ¦ÌM), Bacillus subtilis CMCC 63501(MIC>128 ¦ÌM);##Gram-negative bacteria : Escherichia coli ATCC25922(MIC>128 ¦ÌM), Escherichia coli K88(MIC>128 ¦ÌM), Escherichia coli CVCC 1515(MIC>128 ¦ÌM), Escherichia coli UB1005(MIC>128 ¦ÌM), Bacterium pyocyaneum ATCC 27853(MIC>128 ¦ÌM), Salmonella typhimurium ATCC 14028(MIC>128 ¦ÌM), Salmonella pullorum C79¨C13(MIC>128 ¦ÌM)"	[Ref.26385363] MHC5=2 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26385363] The cell viability of HEK293 cells induced by KL10A0 is 93.9%, 93.3%, 81.9%, 77.2%, 75.6%, 67.8%, 51.9% and 19.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. The cell viability of HEK293 cells induced by control Melitti"	Not found	26385363	Amino Acids.?2016 Feb;48(2):403-17. doi: 10.1007/s00726-015-2094-y.	"Li W, Tan T,?Xu W,?Xu L,?Dong N,?Ma D,?Shan A"	Rational design of mirror-like peptides with alanine regulation.
DRAMP21264	LKKLLKLLKKLLKLAG	16	LK (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=10 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=20 ¦ÌM)	[Ref.23894079] MHC10=0.08 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21265	AKKLLKLLKKLLKLAG	16	LK-L1A (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=10 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=1.25 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21266	LKKALKLLKKLLKLAG	16	LK-L4A (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=1.25 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21267	LKKLAKLLKKLLKLAG	16	LK-L5A (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=10 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10=1.25 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21268	LKKLLKALKKLLKLAG	16	LK-L7A (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=10 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10=1.25 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21269	LKKLLKLAKKLLKLAG	16	LK-L8A (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=1.25 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21270	LKKLLKLLKKALKLAG	16	LK-L11A (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=1.25 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21271	LKKLLKLLKKLAKLAG	16	LK-L12A (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=10 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10=0.63 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21272	LKKLLKLLKKLLKAAG	16	LK-L14A (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=10 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10=1.25 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21273	LKKLLKLGKKLLKLAG	16	LK-L8G (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=5 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2.5 ¦ÌM)	[Ref.23894079] MHC10=10 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21274	LKKLLKLSKKLLKLAG	16	LK-L8S (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=10 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2.5 ¦ÌM)	[Ref.23894079] MHC10=20 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21275	LKKLLKLPKKLLKLAG	16	LK-L8P (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=160 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21276	LKKLLKLNKKLLKLAG	16	LK-L8N (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2.5 ¦ÌM)	[Ref.23894079] MHC10=640 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21277	LKKLLKLQKKLLKLAG	16	LK-L8Q (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2.5 ¦ÌM)	[Ref.23894079] MHC10=320 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21278	LKKLLKLDKKLLKLAG	16	LK-L8D (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10=1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21279	LKKLLKLEKKLLKLAG	16	LK-L8E (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=320 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21280	LKKLLKLKKKLLKLAG	16	LK-L8K (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=160 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21281	LKKLLKLHKKLLKLAG	16	LK-L8H (Derived from LK)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2.5 ¦ÌM)	[Ref.23894079] MHC10=80 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21282	AKRIVQRIKDFLR	13	Lt-F1A (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>640 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21283	FKRAVQRIKDFLR	13	Lt-I4A (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10>640 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21284	FKRIAQRIKDFLR	13	Lt-V5A (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=320 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21285	FKRIVQRAKDFLR	13	Lt-I8A (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>640 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21286	FKRIVQRIKDALR	13	Lt-F11A (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10>640 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21287	FKRIVQRIKDFAR	13	Lt-F12A (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>640 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21288	FKRGVQRIKDFLR	13	Lt-I4G (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21289	FKRSVQRIKDFLR	13	Lt-I4S (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21290	FKRNVQRIKDFLR	13	Lt-I4N (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=20 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21291	FKRQVQRIKDFLR	13	Lt-I4Q (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21292	FKRHVQRIKDFLR	13	Lt-I4H (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21293	FKRIGQRIKDFLR	13	Lt-V5G (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21294	FKRISQRIKDFLR	13	Lt-V5S (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=640 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21295	FKRINQRIKDFLR	13	Lt-V5N (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21296	FKRIQQRIKDFLR	13	Lt-V5Q (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10=1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21297	FKRIHQRIKDFLR	13	Lt-V5H (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21298	FKRIVQRIKDGLR	13	Lt-F11G (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=20 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21299	FKRIVQRIKDSLR	13	Lt-F11S (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21300	FKRIVQRIKDNLR	13	Lt-F11N (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=20 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21301	FKRIVQRIKDQLR	13	Lt-F11Q (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21302	FKRIVQRIKDHLR	13	Lt-F11H (Derived from Lt)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.	[Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 ¦ÌM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=10 ¦ÌM)	[Ref.23894079] MHC10>1280 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.23894079] No cytotoxicity information found.	Not found	23894079	ChemMedChem.?2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.	"Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J"	Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of ¦Á-helical amphipathic peptides.
DRAMP21303	RIIDLLARVRRPQKPKFVTVWVR	23	A7-PMAP-23 (Derived from PMAP-23)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Alpha helix, beta turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.10527878] Gram-positive bacteria : Bacillus subtilis (KCTC 1918)(MIC=1.56 ¦ÌM), Streptococcus pyogenes (KCTC 3096)(MIC=1.56 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=3.125 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=3.125 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=1.56 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=1.56 ¦ÌM)"	[Ref.10527878] 0% hemolysis at 100 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.10527878] No cytotoxicity information found.	Not found	10527878	Biochem Biophys Res Commun.?1999 Oct 14;264(1):281-6.	"Kang JH,?Shin SY,?Jang SY,?Kim KL,?Hahm KS."	Effects of tryptophan residues of porcine myeloid antibacterial?peptide?PMAP-23 on antibiotic activity.
DRAMP21304	RIIDLLWRVRRPQKPKFVTVAVR	23	A21-PMAP-23 (Derived from PMAP-23)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Alpha helix, beta turn"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.10527878] Gram-positive bacteria : Bacillus subtilis (KCTC 1918)(MIC=3.125 ¦ÌM), Streptococcus pyogenes (KCTC 3096)(MIC=3.125 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=6.25 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=6.25 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=3.125 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=3.125 ¦ÌM)"	[Ref.10527878] 0% hemolysis at 100 ¦ÌM against human red blood cells	Linear	Free	Free	None	L	[Ref.10527878] No cytotoxicity information found.	Not found	10527878	Biochem Biophys Res Commun.?1999 Oct 14;264(1):281-6.	"Kang JH,?Shin SY,?Jang SY,?Kim KL,?Hahm KS."	Effects of tryptophan residues of porcine myeloid antibacterial?peptide?PMAP-23 on antibiotic activity.
DRAMP21305	RRRRRRRR	8	R8 (De novo synthesis)	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Alpha helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	[Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=44 ¦ÌM);##Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=44 ¦ÌM)	[Ref.23085001] HC50>128 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	[Ref.23085001] No cytotoxicity information found.	Not found	23085001	Biochim Biophys Acta.?2013 Feb;1828(2):223-32. doi: 10.1016/j.bbamem.2012.10.010.	"Bahnsen JS,?Franzyk H,?Sandberg-Schaal A,?Nielsen HM"	Antimicrobial?and cell-penetrating properties of penetratin?analogs: effect of sequence and secondary structure.
DRAMP21306	FVQWWSKWLGRIL	13	TL-1 (Derived from Temporin-1Tl (TL))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26311041] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=2 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=4 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=4 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=32 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.26311041] HC50=21.4 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26311041] The cell viability of RAW264.7 macrophages cells induced by TL-1 is 112.2%, 109.3% and 109.3% at peptide concentrations of 2.5, 5 and 10 ¦ÌM."	Not found	26311041	J Pept Sci.?2015 Oct;21(10):779-85. doi: 10.1002/psc.2807.	"Rajasekaran G,?Kamalakannan R,?Shin SY"	"Enhancement of the anti-inflammatory activity of temporin-1Tl-derived?antimicrobial?peptides?by tryptophan, arginine and lysine substitutions."
DRAMP21307	FVRWWSKWLRRIL	13	TL-2 (Derived from Temporin-2Tl (TL))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26311041] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.26311041] HC50=8.5 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26311041] The cell viability of RAW264.7 macrophages cells induced by TL-2 is 111.8%, 112.5% and 81.0% at peptide concentrations of 2.5, 5 and 10 ¦ÌM."	Not found	26311041	J Pept Sci.?2015 Oct;21(10):779-85. doi: 10.1002/psc.2807.	"Rajasekaran G,?Kamalakannan R,?Shin SY"	"Enhancement of the anti-inflammatory activity of temporin-1Tl-derived?antimicrobial?peptides?by tryptophan, arginine and lysine substitutions."
DRAMP21308	FVRWWSRWLRRIL	13	TL-3 (Derived from Temporin-3Tl (TL))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26311041] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=8 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=4 ¦ÌM)"	[Ref.26311041] HC50=8.0 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26311041] The cell viability of RAW264.7 macrophages cells induced by TL-3 is 117.4%, 111.5% and 110.5% at peptide concentrations of 2.5, 5 and 10 ¦ÌM."	Not found	26311041	J Pept Sci.?2015 Oct;21(10):779-85. doi: 10.1002/psc.2807.	"Rajasekaran G,?Kamalakannan R,?Shin SY"	"Enhancement of the anti-inflammatory activity of temporin-1Tl-derived?antimicrobial?peptides?by tryptophan, arginine and lysine substitutions."
DRAMP21309	FVKWWSKWLKKIL	13	TL-4 (Derived from Temporin-4Tl (TL))	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.26311041] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 ¦ÌM), Staphylococcus epidermidis (KCTC 1917)(MIC=8 ¦ÌM), Staphylococcus aureus (KCTC 1621)(MIC=2 ¦ÌM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 ¦ÌM), Pseudomonas aeruginosa (KCTC 1637)(MIC=16 ¦ÌM), Salmonella typhimurium (KCTC 1926)(MIC=2 ¦ÌM)"	[Ref.26311041] HC50=15.9 ¦ÌM against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.26311041] The cell viability of RAW264.7 macrophages cells induced by TL-4 is 116.7%, 118.2% and 87.2% at peptide concentrations of 2.5, 5 and 10 ¦ÌM."	Not found	26311041	J Pept Sci.?2015 Oct;21(10):779-85. doi: 10.1002/psc.2807.	"Rajasekaran G,?Kamalakannan R,?Shin SY"	"Enhancement of the anti-inflammatory activity of temporin-1Tl-derived?antimicrobial?peptides?by tryptophan, arginine and lysine substitutions."
DRAMP21311	RWLRKWTRKRLK	12	2W-1 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=64 ¦ÌM), Staphylococcus aureus 25923 (MIC=32 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=16 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=16 ¦ÌM), Escherichia coli 1005 (MIC=16 ¦ÌM), Staphylococcus typhi (MIC=64 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 2W-1 is 95.9%, 92.4%, 89.0%, 86.4%, 85.7%, 94.1%, 91.9% and 98.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00289.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21312	RRLRWKTRWRLK	12	2W-2 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=16 ¦ÌM), Staphylococcus aureus 25923 (MIC=16 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=16 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=16 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=32 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 2W-2 is 94.8%, 92.1%, 95.5%, 98.3%, 94.5%, 95%, 89.5% and  84.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00290.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21313	RRLRKKTWKRLW	12	2W-3 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=64 ¦ÌM), Staphylococcus aureus 25923 (MIC>128 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=64 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=16 ¦ÌM), Escherichia coli 1005 (MIC=32 ¦ÌM), Staphylococcus typhi (MIC=64 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 2W-3 is 95.2%, 89.7%, 87.2%, 91.6%, 85%, 88.4%, 84.8% AND 89.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00291.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21314	RWLRKWTRKWLK	12	3W-1 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=8 ¦ÌM), Staphylococcus aureus 25923 (MIC=16 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=8 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=16 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 3W-1 is 99.5%, 96.2%, 95.7%, 90.9%, 69.1%, 6.4%, -1% and 0% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00292.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21315	WRLRWKTRWRLK	12	3W-2 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=4 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=4 ¦ÌM), Staphylococcus aureus 11011  (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=8 ¦ÌM),  Acinetobacter baumannii AB1901 (MIC=4 ¦ÌM),  Acinetobacter baumannii AB1902 (MIC=4 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 3W-2 is 100.9%, 96%, 103.4%, 97.2%, 104.7%, 103.6%, 97.6%, 90.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00293.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21316	RRLWKKTWKRLW	12	3W-3 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=8 ¦ÌM), Staphylococcus aureus 25923 (MIC=16 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=8 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=8 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 3W-3 is 94.8%, 100.9%, 93.4%, 94.0%, 93.6%, 73.4%, 14.5% and -1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00294.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21317	RWLRWKTRWRLK	12	3W-4 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=4 ¦ÌM), Staphylococcus aureus 25923 (MIC=16 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=16 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=2 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=8 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 3W-4 is 100.2%, 92.2%, 96.2%, 89.0%, 94.1%, 97.4%, 94.3% and 88.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00295.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21318	RRLRWWTRWRLK	12	3W-5 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=4 ¦ÌM), Staphylococcus aureus 25923 (MIC=8 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=8 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=8 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 3W-5 is 96.4%, 99.1%, 100.2%, 101.4%, 97.8%, 99%, 102.6% and 82.6% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00296.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21319	VRLRVKTRVRLK	12	3V (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=16 ¦ÌM), Staphylococcus aureus 25923 (MIC=64 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=32 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=16 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 3V is 98.6%, 101.4%, 103.4%, 92.4%, 101%, 101.9%, 93.6% and 97.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00297.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21320	LRLRLKTRLRLK	12	3L (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=32 ¦ÌM), Staphylococcus aureus 25923 (MIC=32 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=64 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=16 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 3L is 95.9%, 92.4%, 91.6%, 82.1%, 104.3%, 97.1%, 99.5% and 96.6% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00298.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21321	RWLRWWTRWRLK	12	4W (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=4 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=4 ¦ÌM)"	[Ref.31276398] MHC=128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 4W is 95.3%, 88.3%, 89.7%, 97.9%, 91.2%, 77.6%, 32.8% and 0% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00299.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21322	WRVRWKTRWRVK	12	RTV (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=2 ¦ÌM), Staphylococcus aureus 25923 (MIC=4 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=4 ¦ÌM), Staphylococcus aureus 11011 (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=4 ¦ÌM), Escherichia coli 20411 (MIC=4 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=8 ¦ÌM),  Acinetobacter baumannii AB1902 (MIC=8 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=32 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RTV is 106.6%, 103.1%, 94.0%, 106.4%, 96.4%, 104.8%, 95.5% and 96.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00300.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21323	WRIRWKTRWRIK	12	RTI (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=2 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=2 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=8 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RTI is 103.1%, 97.4%, 103.8%, 106.4%, 96.4%, 104.8%, 95.7% and 96.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00301.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21324	WRFRWKTRWRFK	12	RTF (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=2 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=4 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=8 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RTF is 100.7%, 101.6%, 97.8%, 99.0%, 100.9%, 97.4%, 95.3% and 90.3% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00302.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21325	WRLRWRTRWRLR	12	RTL (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=2 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=4 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=4 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=16 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RTL is 102.2%, 104.5%, 94.8%, 103.1%, 103.6%, 103.6%, 105.5% and 105.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00303.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21326	WRLRWRLRWRLR	12	RLR (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=1 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=1 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=4 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=4 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RLR is 100%, 91.4%, 104.8%, 94.5%, 98.6%, 99.8%, 98.8% and 82.6% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00304.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21327	WRVRWRVRWRVR	12	RVR  (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=1 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=1 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=4 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=2 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=4 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RVR is 97.9%, 98.6%, 91.7%, 102.9%, 102.2%, 100.3%, 98.1% and 97.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00305.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21328	WRTRWRTRWRTR	12	RTR (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=4 ¦ÌM), Staphylococcus aureus 25923 (MIC=8 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=8 ¦ÌM), Staphylococcus aureus 11011 (MIC=4 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=4 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=32 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=32 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC>64 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RTR is 97.2%, 106.9%, 96.7%, 104.0%, 94.5%, 98.6%, 102.2% and 103.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00306.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21329	WRFRWRFRWRFR	12	RFR (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=1 ¦ÌM), Staphylococcus aureus 25923 (MIC=1 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=8 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=4 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=2 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=8 ¦ÌM)."	[Ref.31276398] MHC=64¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RFR is 106.2%, 97.6%, 99.8%, 101.7%, 100.9%, 101.6%, 78.1% and 45.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00307.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21330	WKVKWKVKWKVK	12	KVK (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=1 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=2 ¦ÌM) ;##Gram-negative bacteria: Escherichia coli 25922 (MIC=2 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=1 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=1 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=4 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by KVK is 101.2%, 98.3%, 98.3%, 99.1%, 95.2%, 101.9%, 96.6% and 100.5% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00308.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21331	WKLKWKLKWKLK	12	KLK (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=2 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=4 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=4 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=4 ¦ÌM)."	[Ref.31276398] MHC=128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by KLK is 103.3%, 100.2%, 100.5%, 97.8%, 99.1%, 96.4%, 98.4% and 44.5% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00309.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21332	WKIKWKIKWKIK	12	KIK (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=2 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=2 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=1 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=2 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=4 ¦ÌM)."	[Ref.31276398] MHC=64¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by KIK is 100.7%, 106.9%, 95.5%, 101.6%, 103.1%, 102.8%, 61.9% and 32.2% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00310.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21333	WRVRWKVRWRVK	12	RVK (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=1 ¦ÌM), Staphylococcus aureus 25923 (MIC=2 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC=2 ¦ÌM), Staphylococcus aureus 11011 (MIC=2 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 ¦ÌM), Escherichia coli 1005 (MIC=2 ¦ÌM), Staphylococcus typhi (MIC=2 ¦ÌM), Escherichia coli 20411 (MIC=1 ¦ÌM), Acinetobacter baumannii AB1901 (MIC=2 ¦ÌM), Acinetobacter baumannii AB1902 (MIC=4 ¦ÌM), Pseudomonas aeruginosa 25349 (MIC=4 ¦ÌM)."	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RVK is 101.0%, 98.6%, 100.3%, 103.3%, 104.1%, 101.0%, 103.8% and 91.9% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00311.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21334	SFLTTVKKLVTNLAALAGTVIDTIKCKVTGGCRT	34	"Ranatuerin-2Pb (Frogs, amphibians, animals)"	A0A513ZTP5	Not found	Not found	Lithobates pipiens (Northern leopard frog) (Rana pipiens)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Transcript level	"50% Helix, 7.8% antiparallel, 1.2% parallel, 10.9% turn and 29.8% others in 50% TFE/H2O. ##3.5% Helix, 26.6% antiparallel, 0% parallel, 18.3% turn and"	"Ranatuerin-2Pb might also possess two helical segments at respective N-terminus and C-terminus, and the last two residues are probably included in the helix domain."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31242693] Gram-positive bacteria:Staphylococcus aureus (MIC=8 ¦ÌM; MBC=8 ¦ÌM), MRSA (MIC=16 ¦ÌM; MBC=32 ¦ÌM), Enterococcus faecalis (MIC>256 ¦ÌM; MBC>256 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=8 ¦ÌM; MBC=8 ¦ÌM), Pseudomonas aeruginosa (MIC>256 ¦ÌM; MBC>256 ¦ÌM);##Fungi: Candida albicans (MIC=8 ¦ÌM; MBC=16 ¦ÌM)"	"[Ref.31242693] 7% hemolysis at 2 ¦ÌM, 23% hemolysis at 8 ¦ÌM, 50% hemolysis at 16 ¦ÌM, 71% hemolysis at 32 ¦ÌM, 100% hemolysis at 64 ¦ÌM on horse erythrocytes."	Linear	Free	Free	None	L	"[Ref.31242693] The IC50 values which represents the inhibitory effect of Ranatuerin-2Pb on the proliferation of NCI-H157, MCF-7, U251MG and PC-3 are 1.453 ¦ÌM, 7.254 ¦ÌM, 2.172 ¦ÌM and 2.251 ¦ÌM. In addtion, Ranatuerin-2Pb showed no inhibitory effect on the proliferation of MDA-MB-435s.  DETAILED DATA: ¢ÙThe cell viabillity of NCI-H157 induced by Ranatuerin-2Pb is 96.2%, 96.9%, 85.6%, 60%, 5% and 4.4% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 100%, 95%, 89.4%, 41.2%, 16.2% and 16.2% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÚThe cell viability of MCF-7 induced by Ranatuerin-2Pb is 100.6%, 92.5%, 90%, 99.4%, 36.2% and 11.2% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 100%, 98.1%, 92.5%, 7.5%, 8.7% and 8.7% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÛThe cell viability of U251-MG induced by Ranatuerin-2Pb is 100%, 105.6%, 108.1%, 102.5%, 59.4% and 17.5% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 99.4%, 99.4%, 75.6%, 18.7%, 11.9% and 18.1% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÜThe cell viability of PC-3 induced by Ranatuerin-2Pb is 108.7%, 112.5%, 84.4%, 80.6%, 28.1% and 16.2% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 110%, 113.1%, 109.4%, 33.1%, 16.9% and 16.2% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢Ý The cell viability of MDA-MB-435S induced by Ranatuerin-2Pb is 96.9%, 88.8%, 96.9%, 88.1%, 100 and 25.6%, while the cell viability induced by Melittin is 100%, 93.1%, 82.5%, 18.8%, 18.8% and 18.1%."	Not found	31242693	Biomolecules. 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249.	"Zhou, XW; Shi, DN; Zhong, RM; Ye, ZM; Ma, CB; Zhou, M; Xi, XP; Wang, L; Chen, TB; Kwok, HF"	Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and its Truncated Analogues
DRAMP21335	SFLTTVKKLVTNLAALAGTVIDTIKCKVTGGC	32	"RPa (Frogs, amphibians, animals)"	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"33.6% Helix, 18.1% antiparallel, 4.3% parallel, 11.4% turn and 32.5% others in 50% TFE/H2O. ##2.4% Helix, 30.6% antiparallel, 0% parallel, 17.3% turn "	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31242693] Gram-positive bacteria:Staphylococcus aureus (MIC=16 ¦ÌM; MBC=32 ¦ÌM), MRSA (MIC=>256 ¦ÌM; MBC>256 ¦ÌM), Enterococcus faecalis (MIC>256 ¦ÌM; MBC>256 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=32 ¦ÌM; MBC=64 ¦ÌM), Pseudomonas aeruginosa (MIC>256 ¦ÌM; MBC>256 ¦ÌM);##Fungi: Candida albicans (MIC>256 ¦ÌM; MBC>256 ¦ÌM)"	"[Ref.31242693] 7% hemolysis at 16 ¦ÌM, 23% hemolysis at 32 ¦ÌM, 50% hemolysis at 64 ¦ÌM, 76% hemolysis at 128 ¦ÌM, 90% hemolysis at 256 ¦ÌM, 100% hemolysis at 512 ¦ÌM on horse erythrocytes."	Linear	Free	Free	None	L	"[Ref.31242693] RPa only possessed inhibitory effect on the proliferation of H157 with the IC value of 5.841 ¦ÌM, while showed no inhibitory effect on the proliferation of MCF-7, U251MG, PC-3 and MDA-MB-435s. DETAILED DATA: ¢ÙThe cell viabillity of NCI-H157 induced by RPa is 97.5%, 94.4%, 92.5%, 71.2%, 40.6% and 4.4% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 100%, 95%, 89.4%, 41.2%, 16.2% and 16.2% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÚThe cell viability of MCF-7 induced by RPa is 100.6%, 93.1%, 97.5%, 97.5%, 93.7% and 78.1% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM , while the cell viability induced by Melittin is 100%, 98.1%, 92.5%, 7.5%, 8.7% and 8.7% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÛThe cell viability of U251-MG induced by RPa is 100%, 105.6%, 108.1%, 102.5%, 59.4% and 17.5% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 99.4%, 99.4%, 75.6%, 18.7%, 11.9% and 18.1% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM.¢ÜThe cell viability of PC-3 induced by RPb is 108.7%, 104.4%, 92.5%, 92.5%, 82.5% and 24.4% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 110%, 113.1%, 109.4%, 33.1%, 16.9% and 16.2% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÝThe cell viability of MDA-MB-435S induced by RPa is 97.5%, 95%, 97.5%, 73.1%, 68.8% and 36.9%, while the cell viability induced by Melittin is 100%, 93.1%, 82.5%, 18.8%, 18.8% and 18.1%."	Not found	31242693	Biomolecules. 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249.	"Zhou, XW; Shi, DN; Zhong, RM; Ye, ZM; Ma, CB; Zhou, M; Xi, XP; Wang, L; Chen, TB; Kwok, HF"	Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and its Truncated Analogues
DRAMP21336	SFLTTVKKLVTNLAAL	16	"RPb (Frogs, amphibians, animals)"	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"49.6% Helix, 7.6% antiparallel, 0% parallel, 9.8% turn and 33% others in 50% TFE/H2O. ##0.3% Helix, 25.4% antiparallel, 0% parallel, 19.4% turn and 55"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31242693] Gram-positive bacteria:Staphylococcus aureus (MIC=8 ¦ÌM; MBC=8 ¦ÌM), MRSA (MIC=16 ¦ÌM; MBC=32 ¦ÌM), Enterococcus faecalis (MIC=32 ¦ÌM; MBC=128 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=16 ¦ÌM; MBC=16 ¦ÌM), Pseudomonas aeruginosa (MIC=64 ¦ÌM; MBC=256 ¦ÌM);##Fungi: Candida albicans (MIC=16 ¦ÌM; MBC=16 ¦ÌM)"	"[Ref.31242693] 7% hemolysis at 16 ¦ÌM, 18% hemolysis at 32 ¦ÌM, 20% hemolysis at 64 ¦ÌM, 40% hemolysis at 128 ¦ÌM, 70% hemolysis at 256 ¦ÌM, 100% hemolysis at 512 ¦ÌM on horse erythrocytes. "	Linear	Free	Amidation	None	L	"[Ref.31242693] RPb only possessed inhibitory effect on the proliferation of H157 with the IC value of 6.856 ¦ÌM, while showed no inhibitory effect on the proliferation of MCF-7, U251MG, PC-3 and MDA-MB-435s. DETAILED DATA: ¢ÙThe cell viabillity of NCI-H157 induced by RPb is 98.7%, 102.5%, 96.9%, 98.1%, 38.1%, 9.4% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 100%, 95%, 89.4%, 41.2%, 16.2% and 16.2% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÚThe cell viability of MCF-7 induced by RPb is 100.6%, 92.5%, 90%, 99.4%, 36.2% and 11.2% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, , while the cell viability induced by Melittin is 100%, 98.1%, 92.5%, 7.5%, 8.7% and 8.7% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÛThe cell viability of U251-MG induced by RPb is 105%, 103.1%, 109.4%, 102.5%, 105.6% and 13.1% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 99.4%, 99.4%, 75.6%, 18.7%, 11.9% and 18.1% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM.¢ÜThe cell viability of PC-3 induced by RPa is 108.8%, 103.8%, 118.1%, 125.6%, 116.9% and 68.8% at peptide concentrations of 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM, while the cell viability induced by Melittin is 110%, 113.1%, 109.4%, 33.1%, 16.9% and 16.2% at 0.001, 0.01, 0.1, 1, 10, 100 ¦ÌM. ¢ÝThe cell viability of MDA-MB-435S induced by RPa is 98.1%, 95%, 100.6%, 97.5%, 80.6% and 43.1%, while the cell viability induced by Melittin is 100%, 93.1%, 82.5%, 18.8%, 18.8% and 18.1%."	Not found	31242693	Biomolecules. 2019 Jun 25;9(6):249. doi: 10.3390/biom9060249.	"Zhou, XW; Shi, DN; Zhong, RM; Ye, ZM; Ma, CB; Zhou, M; Xi, XP; Wang, L; Chen, TB; Kwok, HF"	Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and its Truncated Analogues
DRAMP21337	GRFKRFRKKFKKLFKKLSPVIPLLHL	26	"BMAP-27 (Bovine, mammals, animals)"	P54228	Belongs to the?cathelicidin family	CATHL6	Bos taurus (Bovine)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	73% ¦Á-helix in 50% TFE/H2O	An ¦Á-helix occurred from Arg2 to Leu17 in the N-terminal region and a short ¦Á-helix is observed from Leu23 to Leu26 in the Cterminal region; the two regions are connected with a flexible region containing two proline residues. 	2KET resolved by NMR	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.31226350] Gram-positive bacteria:Staphylococcus aureus (MIC=1-2 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2-4 ¦ÌM)	[Ref.31226350] 50% hemolysis at 75 ¦ÌM for human red blood cells	Linear	Free	Amidation	None	L	"[Ref.31226350] The CC50 values which represent peptide concentration (¦ÌM) inducing 50% cytotoxicity to human cancer cell lines of BMAP-27 on MDA361 and A549 are 4.2 ¦ÌM and 5.3 ¦ÌM.  DETAILED DATA: ¢ÙThe cell viability of MDA-361 induced by BMAP-27 is 100%, 100%, 98.9%, 97.7%, 87.6%, 59.8%, 34.7%, 12.4%, 10.3%, 8.3% and 9.4% at peptide concentrations of 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.4, 13, 25, 50 and 100 ¦ÌM. ¢ÚThe cell viability of A549 induced by BMAP-27 is 100%, 99.1%, 97.7%, 94.7%, 74.5%, 41.4%, 24.4%, 11.3%, 9.7%, 10.3% and 7.4% at peptide concentrations of 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.4, 13, 25, 50 and 100 ¦ÌM."	Not found	31226350	Peptides.?2019 Jun 18;118:170106. doi: 10.1016/j.peptides.2019.170106.	"Yang S,?Lee CW,?Kim HJ,?Jung HH,?Kim JI,?Shin SY,?Shin SH"	"Structural analysis and mode of action of BMAP-27, a cathelicidin-derived antimicrobial peptide"
DRAMP21338	FLRALWNVAKSVF	13	[Arg]3-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	23% ¦Á-helix in 60% TFE/Water. ## 0%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4560.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=1.6?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=1.6?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=0.8?¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=0.8?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=1.6?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.4?¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=6.3?¦Ìmol/L), Pseudomonas aeruginosa ATCC 27853 (MIC=6.3?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=0.8?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.8?¦Ìmol/L)"	"[Ref.31212183] 25% hemolysis at 6.3 ¦Ìmol/L, 65% hemolysis at 25 ¦Ìmol/L, 75% hemolysis at 50 ¦Ìmol/L, 100% hemolysis at 100 ¦Ìmol/L for human red blood cells"	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21339	FLGALWRVAKSVF	13	[Arg]7-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	22% ¦Á-helix in 60% TFE/Water. ## 0%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4561.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=1.6?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=1.6?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=0.4?¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=0.8?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=1.6?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.2?¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=6.3?¦Ìmol/L), Pseudomonas aeruginosa ATCC 27853 (MIC=6.3?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=0.8?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.8?¦Ìmol/L)"	"[Ref.31212183] 10% hemolysis at 6.3 ¦Ìmol/L, 50% hemolysis at 12.5 ¦Ìmol/L, 60% hemolysis at 25 ¦Ìmol/L, 90% hemolysis at 500 ¦Ìmol/L for human red blood cells"	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21340	FLGALWNVAKRVF	13	[Arg]11-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	25% ¦Á-helix in 60% TFE/Water. ## 2%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4562.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=1.6?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=1.6?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=0.8?¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=0.8?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=1.6?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.2?¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=6.3?¦Ìmol/L), Pseudomonas aeruginosa ATCC 27853 (MIC=12.5?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=0.8?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.8?¦Ìmol/L)"	"[Ref.31212183] 25% hemolysis at 6.3 ¦Ìmol/L, 50% hemolysis at 12.5 ¦Ìmol/L, 70% hemolysis at 25 ¦Ìmol/L, 90% hemolysis at 500 ¦Ìmol/L for human red blood cells"	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21341	GLGALWNVAKSVF	13	[Gly]1-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	37% ¦Á-helix in 60% TFE/Water. ## 2%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4563.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.8?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=25?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=3.1?¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=3.1?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=50?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.4?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=25?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=6.3?¦Ìmol/L)"	"[Ref.31212183] 10% hemolysis at 50 ¦Ìmol/L, 30% hemolysis at 100 ¦Ìmol/L for human red blood cells"	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21342	FLGALWNPAKSVF	13	[Pro]8-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	12% ¦Á-helix in 60% TFE/Water. ## 2%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida tropicalis IOC 4564.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=12.5?¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=50?¦Ìmol/L);##Gram-negative bacteria: Serratia marcescens ATCC 4112 (MIC=12.5?¦Ìmol/L);##Fungi: Candida tropicalis IOC 4560 (MIC=50?¦Ìmol/L)"	[Ref.31212183] 0% hemolysis at 100 ¦Ìmol/L for human red blood cells	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21343	FLGALWNVLKSVF	13	[Leu]9-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	62% ¦Á-helix in 60% TFE/Water. ## 3%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4565.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=0.8?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=3.1?¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=0.8?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=0.8?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.4?¦Ìmol/L), Pseudomonas aeruginosa ATCC 27853 (MIC=50?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=1.6?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=1.6?¦Ìmol/L)"	"[Ref.31212183] 20% hemolysis at 3.1 ¦Ìmol/L, 70% hemolysis at 25 ¦Ìmol/L, 100% hemolysis at 100 ¦Ìmol/L for human red blood cells"	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21344	FLGALWNVFKSVF	13	[Phe]9-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	32% ¦Á-helix in 60% TFE/Water. ## 1%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4566.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.2?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=0.8?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=1.6?¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=0.8?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=1.6?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.2?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=6.3?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.8?¦Ìmol/L)"	"[Ref.31212183] 10% hemolysis at 1.6 ¦Ìmol/L, 40% hemolysis at 3.1 ¦Ìmol/L, 60% hemolysis at 6.3 ¦Ìmol/L, 85% hemolysis at 25 ¦Ìmol/L for human red blood cells"	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21345	FLGALWNVAKSLF	13	[Leu]12-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	23% ¦Á-helix in 60% TFE/Water. ## 2%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4567.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=0.8?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=1.6¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=0.8?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=0.8?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.4?¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=6.3?¦Ìmol/L), Pseudomonas aeruginosa ATCC 27853 (MIC=50?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=3.1?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=1.6?¦Ìmol/L)"	"[Ref.31212183] 20% hemolysis at 6.3 ¦Ìmol/L, 60% hemolysis at 12.5 ¦Ìmol/L, 75% hemolysis at 25 ¦Ìmol/L, 90% hemolysis at 50 ¦Ìmol/L for human red blood cells"	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21346	FLGALWNVAKSYF	13	[Tyr]12-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	24% ¦Á-helix in 60% TFE/Water. ## 2%¦Á-helix in water.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4568.	"[Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.8?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=1.6?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=1.6?¦Ìmol/L), Bacillus subtilis ATCC 6633 (MIC=1.6?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=6.3?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.2?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=12.5?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=6.3?¦Ìmol/L)"	"[Ref.31212183] 25% hemolysis at 12.5 ¦Ìmol/L, 60% hemolysis at 25 ¦Ìmol/L, 85% hemolysis at 50 ¦Ìmol/L, 100% hemolysis at 100 ¦Ìmol/L for human red blood cells"	Linear	Free	Amidation	None	L	[Ref.31212183] No cytotoxicity information found	Not found	31212183	Bioorg Chem.?2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.	"Pedron CN,?Ara¨²jo I,?da Silva Junior PI,?Dias da Silva F,?Torres MT,?Oliveira Junior VX"	Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens
DRAMP21347	IHHIHHH	7	2IH1 (De Novo Synthesis) 	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	18% ¦Á-helix in 50% TFE/H2O	"The ¦Á-helical coiled coils would show a sequence periodicity of seven residues (heptad repeat), indicated as ¡°abcdefg¡±, with hydrophobic residues in the ¡°a¡± and ¡°d¡± positions ¡°forming the knobs-into-holes packing interactions and providing the energy needed to distort the mechanical-stabilized ¦Á-helices¡±."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31199117] Gram-negative Bacteria: Escherichia coli 25922 (MIC>64¦ÌM), Escherichia coli UB1005 (MIC>64¦ÌM), Escherichia coli K88 (MIC>64¦ÌM), Escherichia coli K99 (MIC>64¦ÌM), Escherichia coli 078 (MIC>64¦ÌM), Escherichia coli 987P (MIC>64¦ÌM), Pseudomonas aeruginosa 27853 (MIC>64¦ÌM), Pseudomonas aeruginosa PAO1 (MIC>64¦ÌM), Salmonella typhimurium 14028 (MIC>64¦ÌM), Salmonella typhimurium 7731 (MIC>64¦ÌM)"	"[Ref.31199117] 5% hemolysis at 63¦ÌM, 8% hemolysis at 128¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31199117] ¢ÙThe cell viability of HEK293T cells induced by 2IH1 is 103.6%, 102.2%, 101.7%, 103.9%, 103.6%, 106.1% and 103.3% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. ¢ÚThe cell viability of HEK293T cells induced by 2IH1 is 107.9%, 104.5%, 103.4%, 102.5%, 101.1%, 105.6% and 102.0% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	31199117	ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.	"Lai Z,?Tan P,?Zhu Y,?Shao C,?Shan A,?Li L."	Highly Stabilized ¦Á-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
DRAMP21348	IHHIHHHIHHIHHH	14	2IH2 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	95% ¦Á-helix in 50% TFE/H2O	"The ¦Á-helical coiled coils would show a sequence periodicity of seven residues (heptad repeat), indicated as ¡°abcdefg¡±, with hydrophobic residues in the ¡°a¡± and ¡°d¡± positions ¡°forming the knobs-into-holes packing interactions and providing the energy needed to distort the mechanical-stabilized ¦Á-helices¡±."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31199117] Gram-negative Bacteria: Escherichia coli 25922 (MIC=64¦ÌM), Escherichia coli UB1005 (MIC=64¦ÌM), Escherichia coli K88 (MIC>64¦ÌM), Escherichia coli K99 (MIC=64¦ÌM), Escherichia coli 078 (MIC>64¦ÌM), Escherichia coli 987P (MIC=64¦ÌM), Pseudomonas aeruginosa 27853 (MIC=8¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=64¦ÌM), Salmonella typhimurium 14028 (MIC>64¦ÌM), Salmonella typhimurium 7731 (MIC>64¦ÌM)"	"[Ref.31199117] 5% hemolysis at 63¦ÌM, 8% hemolysis at 128¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31199117] ¢ÙThe cell viability of HEK293T cells induced by 2IH2 is 104.7%, 104.7%, 102.8%, 103.6%, 105.3%, 102.2% and 102.5% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. ¢ÚThe cell viability of HEK293T cells induced by 2IH2 is 105.1%, 104.8%, 103.7%, 104.2%, 104.2%, 105.6%, 104.2% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	31199117	ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.	"Lai Z,?Tan P,?Zhu Y,?Shao C,?Shan A,?Li L."	Highly Stabilized ¦Á-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
DRAMP21349	IHHIHHHIHHIHHHIHHIHHH	21	2IH3 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	95% ¦Á-helix in 50% TFE/H2O	"The ¦Á-helical coiled coils would show a sequence periodicity of seven residues (heptad repeat), indicated as ¡°abcdefg¡±, with hydrophobic residues in the ¡°a¡± and ¡°d¡± positions ¡°forming the knobs-into-holes packing interactions and providing the energy needed to distort the mechanical-stabilized ¦Á-helices¡±."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31199117] Gram-negative Bacteria: Escherichia coli 25922 (MIC=2¦ÌM), Escherichia coli UB1005 (MIC=2¦ÌM), Escherichia coli K88 (MIC=2¦ÌM), Escherichia coli K99 (MIC=2¦ÌM), Escherichia coli 078 (MIC=4¦ÌM), Escherichia coli 987P (MIC=2¦ÌM), Pseudomonas aeruginosa 27853 (MIC=0.5¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=1¦ÌM), Salmonella typhimurium 14028 (MIC=16>64¦ÌM), Salmonella typhimurium 7731 (MIC=8¦ÌM)"	"[Ref.31199117] 5% hemolysis at 63¦ÌM, 8% hemolysis at 128¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31199117] ¢ÙThe cell viability of HEK293T cells induced by 2IH3 is 108.3%, 102.8%, 104.4%, 102.2%, 105%, 105.3% and 103.3% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. ¢ÚThe cell viability of HEK293T cells induced by 2IH3 is 102.5%, 104.5%, 105.6%, 103.7%, 102.0%, 103.1% and 103.1% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	31199117	ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.	"Lai Z,?Tan P,?Zhu Y,?Shao C,?Shan A,?Li L."	Highly Stabilized ¦Á-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
DRAMP21350	IHHIHHHIHHIHHHIHHIHHHIHHIHHH	28	2IH4 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	95% ¦Á-helix in 50% TFE/H2O	"The ¦Á-helical coiled coils would show a sequence periodicity of seven residues (heptad repeat), indicated as ¡°abcdefg¡±, with hydrophobic residues in the ¡°a¡± and ¡°d¡± positions ¡°forming the knobs-into-holes packing interactions and providing the energy needed to distort the mechanical-stabilized ¦Á-helices¡±."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31199117] Gram-negative Bacteria: Escherichia coli 25922 (MIC=1¦ÌM), Escherichia coli UB1005 (MIC=2¦ÌM), Escherichia coli K88 (MIC=4>64¦ÌM), Escherichia coli K99 (MIC=1¦ÌM), Escherichia coli 078 (MIC=4>64¦ÌM), Escherichia coli 987P (MIC=1¦ÌM), Pseudomonas aeruginosa 27853 (MIC=1¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=1¦ÌM), Salmonella typhimurium 14028 (MIC=64¦ÌM), Salmonella typhimurium 7731 (MIC>64¦ÌM)"	"[Ref.31199117] 5% hemolysis at 63¦ÌM, 8% hemolysis at 128¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31199117] ¢ÙThe cell viability of HEK293T cells induced by 2IH4 is  at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. ¢ÚThe cell viability of HEK293T cells induced by 2IH4 is 103.7%, 103.7%, 104.8%, 103.4%, 105.3%, 94.9% and 57.9% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	31199117	ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.	"Lai Z,?Tan P,?Zhu Y,?Shao C,?Shan A,?Li L."	Highly Stabilized ¦Á-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
DRAMP21351	IHHIHHI	7	3IH1 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	53% ¦Á-helix in 50% TFE/H2O	"The ¦Á-helical coiled coils would show a sequence periodicity of seven residues (heptad repeat), indicated as ¡°abcdefg¡±, with hydrophobic residues in the ¡°a¡± and ¡°d¡± positions ¡°forming the knobs-into-holes packing interactions and providing the energy needed to distort the mechanical-stabilized ¦Á-helices¡±."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31199117] Gram-negative Bacteria: Escherichia coli 25922 (MIC>64¦ÌM), Escherichia coli UB1005 (MIC>64¦ÌM), Escherichia coli K88 (MIC>64¦ÌM), Escherichia coli K99 (MIC>64¦ÌM), Escherichia coli 078 (MIC>64¦ÌM), Escherichia coli 987P (MIC>64¦ÌM), Pseudomonas aeruginosa 27853 (MIC>64¦ÌM), Pseudomonas aeruginosa PAO1 (MIC>64¦ÌM), Salmonella typhimurium 14028 (MIC>64¦ÌM), Salmonella typhimurium 7731 (MIC>64¦ÌM)"	"[Ref.31199117] 5% hemolysis at 63¦ÌM, 8% hemolysis at 128¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31199117] ¢ÙThe cell viability of HEK293T cells induced by 3IH1 is 105.6%, 101.1%, 100.6%, 102.5%, 100.3%, 101.4% and 101.1% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. ¢ÚThe cell viability of HEK293T cells induced by 3IH1 is 102.2%, 103.1%, 102.0%, 103.4%, 103.1%, 102.0% and 101.7% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	31199117	ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.	"Lai Z,?Tan P,?Zhu Y,?Shao C,?Shan A,?Li L."	Highly Stabilized ¦Á-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
DRAMP21352	IHHIHHIIHHIHHI	14	3IH2 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	95% ¦Á-helix in 50% TFE/H2O	"The ¦Á-helical coiled coils would show a sequence periodicity of seven residues (heptad repeat), indicated as ¡°abcdefg¡±, with hydrophobic residues in the ¡°a¡± and ¡°d¡± positions ¡°forming the knobs-into-holes packing interactions and providing the energy needed to distort the mechanical-stabilized ¦Á-helices¡±."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31199117] Gram-negative Bacteria: Escherichia coli 25922 (MIC=4¦ÌM), Escherichia coli UB1005 (MIC=8¦ÌM), Escherichia coli K88 (MIC=4¦ÌM), Escherichia coli K99 (MIC=4¦ÌM), Escherichia coli 078 (MIC=8¦ÌM), Escherichia coli 987P (MIC=2¦ÌM), Pseudomonas aeruginosa 27853 (MIC=4¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=4¦ÌM), Salmonella typhimurium 14028 (MIC=32¦ÌM), Salmonella typhimurium 7731 (MIC=16¦ÌM)"	"[Ref.31199117] 5% hemolysis at 63¦ÌM, 8% hemolysis at 128¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31199117] ¢ÙThe cell viability of HEK293T cells induced by 3IH2 is 105.8%, 105.8%, 105.2%, 104.2%, 101.1%, 101.7% and 100.8% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. ¢ÚThe cell viability of HEK293T cells induced by 3IH2 is 106.2%, 105.9%, 105.9%, 105.6%, 104.2%, 104.8% and 101.4% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	31199117	ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.	"Lai Z,?Tan P,?Zhu Y,?Shao C,?Shan A,?Li L."	Highly Stabilized ¦Á-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
DRAMP21353	IHHIHHIIHHIHHIIHHIHHI	21	3IH3 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	95% ¦Á-helix in 50% TFE/H2O	"The ¦Á-helical coiled coils would show a sequence periodicity of seven residues (heptad repeat), indicated as ¡°abcdefg¡±, with hydrophobic residues in the ¡°a¡± and ¡°d¡± positions ¡°forming the knobs-into-holes packing interactions and providing the energy needed to distort the mechanical-stabilized ¦Á-helices¡±."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31199117] Gram-negative Bacteria: Escherichia coli 25922 (MIC=1¦ÌM), Escherichia coli UB1005 (MIC=1¦ÌM), Escherichia coli K88 (MIC=1¦ÌM), Escherichia coli K99 (MIC=1¦ÌM), Escherichia coli 078 (MIC=0.5¦ÌM), Escherichia coli 987P (MIC=0.5¦ÌM), Pseudomonas aeruginosa 27853 (MIC=1¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=0.5¦ÌM), Salmonella typhimurium 14028 (MIC=2¦ÌM), Salmonella typhimurium 7731 (MIC=1¦ÌM)"	"[Ref.31199117] 5% hemolysis at 63¦ÌM, 8% hemolysis at 128¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31199117] ¢ÙThe cell viability of HEK293T cells induced by 3IH3 is 103.6%, 102.2%, 102.8%, 105%, 103.1%, 104.2% and 105.8% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. ¢ÚThe cell viability of HEK293T cells induced by 3IH3 is 103.9%, 103.1%, 103.9%, 102.2%, 104.2%, 103.1% and 101.7% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	31199117	ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.	"Lai Z,?Tan P,?Zhu Y,?Shao C,?Shan A,?Li L."	Highly Stabilized ¦Á-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
DRAMP21354	IHHIHHIIHHIHHIIHHIHHIIHHIHHI	28	3IH4 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	95% ¦Á-helix in 50% TFE/H2O	"The ¦Á-helical coiled coils would show a sequence periodicity of seven residues (heptad repeat), indicated as ¡°abcdefg¡±, with hydrophobic residues in the ¡°a¡± and ¡°d¡± positions ¡°forming the knobs-into-holes packing interactions and providing the energy needed to distort the mechanical-stabilized ¦Á-helices¡±."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31199117] Gram-negative Bacteria: Escherichia coli 25922 (MIC=2¦ÌM), Escherichia coli UB1005 (MIC=4¦ÌM), Escherichia coli K88 (MIC=2¦ÌM), Escherichia coli K99 (MIC=4¦ÌM), Escherichia coli 078 (MIC=4¦ÌM), Escherichia coli 987P (MIC=4¦ÌM), Pseudomonas aeruginosa 27853 (MIC=8¦ÌM), Pseudomonas aeruginosa PAO1 (MIC=4¦ÌM), Salmonella typhimurium 14028 (MIC>64¦ÌM), Salmonella typhimurium 7731 (MIC>64¦ÌM)"	"[Ref.31199117] 8% hemolysis at 63¦ÌM, 15% hemolysis at 128¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31199117] ¢ÙThe cell viability of HEK293T cells induced by 3IH4 is 106.9%, 101.1%, 101.9%, 103.6%, 102.5%, 101.7% and 80.6% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 7.4, while that induced by Melittin is 47.2%, 1.7%, 1.9%, 0.6%, 0.6%, 0.6% and 1.7% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM. ¢ÚThe cell viability of HEK293T cells induced by 3IH4 is 104.2%, 105.3, 104.2%, 104.2%, 101.4%, 100.6%, 56.5% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 ¦ÌM at pH 6.0, while that induced by Melittin is 43.8%, 3.4%, 3.4%, 0%, 2.2%, 0% and 1.1% at 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	31199117	ACS Appl Mater Interfaces. 2019 Jun 26;11(25):22113-22128. doi: 10.1021/acsami.9b04654. Epub 2019 Jun 14.	"Lai Z,?Tan P,?Zhu Y,?Shao C,?Shan A,?Li L."	Highly Stabilized ¦Á-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition
DRAMP21355	KKKKKAAFAKAWAAFAA	17	5Kamp (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=6.3¦ÌM), Pseudomonas aeruginosa PAO1(MIC=25¦ÌM), Pseudomonas aeruginosa PA214(MIC=25¦ÌM), Pseudomonas aeruginosa PA287(MIC=50¦ÌM), Pseudomonas aeruginosa PA330(MIC=50¦ÌM), Pseudomonas aeruginosa PA380(MIC=50¦ÌM)"	[Ref.31194548] 0% hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21356	KKKKAAFAKAWAKAFAA	17	4Kamp (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=12.5¦ÌM), Pseudomonas aeruginosa PAO1(MIC=50¦ÌM), Pseudomonas aeruginosa PA214(MIC=50¦ÌM), Pseudomonas aeruginosa PA287(MIC>50¦ÌM), Pseudomonas aeruginosa PA330(MIC>50¦ÌM), Pseudomonas aeruginosa PA380(MIC=50¦ÌM)"	[Ref.31194548] 0% hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21357	KKKAAFAKAWAKAFKAA	17	3Kamp (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=25¦ÌM), Pseudomonas aeruginosa PAO1(MIC=50¦ÌM), Pseudomonas aeruginosa PA214(MIC=50¦ÌM), Pseudomonas aeruginosa PA287(MIC>50¦ÌM), Pseudomonas aeruginosa PA330(MIC>50¦ÌM), Pseudomonas aeruginosa PA380(MIC>50¦ÌM)"	[Ref.31194548] 0% hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21358	KKAKAFAKAWAKAFKAA	17	2Kamp (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=12.5¦ÌM), Pseudomonas aeruginosa PAO1(MIC=25¦ÌM), Pseudomonas aeruginosa PA214(MIC=50¦ÌM), Pseudomonas aeruginosa PA287(MIC=50¦ÌM), Pseudomonas aeruginosa PA330(MIC>50¦ÌM), Pseudomonas aeruginosa PA380(MIC>50¦ÌM)"	[Ref.31194548] 0% hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21359	KAAKKFAKAWAKAFKAA	17	1Kamp (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=12.5¦ÌM), Pseudomonas aeruginosa PAO1(MIC=50¦ÌM), Pseudomonas aeruginosa PA214(MIC>50¦ÌM), Pseudomonas aeruginosa PA287(MIC>50¦ÌM), Pseudomonas aeruginosa PA330(MIC>50¦ÌM), Pseudomonas aeruginosa PA380(MIC>50¦ÌM)"	[Ref.31194548] 0% hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21360	KKKKKKALFALWLAFLA	17	6K-F17-4L (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=12.5¦ÌM), Pseudomonas aeruginosa PAO1(MIC>50¦ÌM), Pseudomonas aeruginosa PA214(MIC=50¦ÌM), Pseudomonas aeruginosa PA287(MIC=25¦ÌM), Pseudomonas aeruginosa PA330(MIC>50¦ÌM), Pseudomonas aeruginosa PA380(MIC>50¦ÌM)"	[Ref.31194548] 33% (¡À 22) hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21361	KKKKKALFLKLWAAFLA	17	5Kamp-4L (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=3.1¦ÌM), Pseudomonas aeruginosa PAO1(MIC=12.5¦ÌM), Pseudomonas aeruginosa PA214(MIC=6.3¦ÌM), Pseudomonas aeruginosa PA287(MIC=6.3¦ÌM), Pseudomonas aeruginosa PA330(MIC=12.5¦ÌM), Pseudomonas aeruginosa PA380(MIC>50¦ÌM)"	[Ref.31194548] 49% (¡À 22) hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21362	KKKKAAFLKLWLKLFAA	17	4Kamp-4L (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=12.5¦ÌM), Pseudomonas aeruginosa PAO1(MIC>50¦ÌM), Pseudomonas aeruginosa PA214(MIC>50¦ÌM), Pseudomonas aeruginosa PA287(MIC>50¦ÌM), Pseudomonas aeruginosa PA330(MIC>50¦ÌM), Pseudomonas aeruginosa PA380(MIC>50¦ÌM)"	[Ref.31194548] 8% (¡À 2.0) hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21363	KKKAAFLKLWAKLFKAL	17	3Kamp-4L (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=3.1¦ÌM), Pseudomonas aeruginosa PAO1(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA214(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA287(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA330(MIC=6.3¦ÌM), Pseudomonas aeruginosa PA380(MIC=3.1¦ÌM)"	[Ref.31194548] 100% (¡À 4.5) hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21364	KKLKAFLKAWAKLFKAL	17	2Kamp-4L (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=1.6¦ÌM), Pseudomonas aeruginosa PAO1(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA214(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA287(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA330(MIC=6.3¦ÌM), Pseudomonas aeruginosa PA380(MIC=1.5¦ÌM)"	[Ref.31194548] 89% (¡À 7.3) hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21365	KALKKFLKAWAKLFKAL	17	1Kamp-4L (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM Tris buffer 10 Mm NaCl pH 7.4, supplemented with either 2 mg/ml E.coli or POPC lipid extract."	"Peptides are shown as ideal helices with side chains shown as stick models for Lys, Trp, and Phe and  as space-filling models."	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.31194548] Gram-negative Bacteria: Escherichia coli K12 (MIC=1.6¦ÌM), Pseudomonas aeruginosa PAO1(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA214(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA287(MIC=3.1¦ÌM), Pseudomonas aeruginosa PA330(MIC=6.3¦ÌM), Pseudomonas aeruginosa PA380(MIC=6.3¦ÌM)"	[Ref.31194548] 81% (¡À 9.4) hemolysis at 40¦ÌM against human blood cells.	Linear	Free	Amidation	None	L	[Ref.31194548] No cytotoxicity information found	Not found	31194548	J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.	"Stone TA,?Cole GB,?Ravamehr-Lake D,?Nguyen HQ,?Khan F,?Sharpe S,?Deber CM"	"Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability"
DRAMP21366	KLGALWNVAKSVF	13	[Lys]1-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"3% Helical content in water, 2% helical content in PBS (pH7.4), 30% helical content in SDS (20 mmol/L), 32% helical content in TFE/Water (3:2, v:v), 4"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans MDM8 and Candida tropicalis IOC 4560.	"[Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=25?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=3.1?¦Ìmol/L);##Gram-negative bacteria: Serratia marcescens ATCC 4112 (MIC=1.6?¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=25?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=3.1?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.8?¦Ìmol/L)"	"[Ref.31181304] 15% hemolysis at 25 ¦Ìmol/L, 25% hemolysis at 50 ¦Ìmol/L, 40% hemolysis at 100 ¦Ìmol/L against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31181304] The cell viability of MCF-7 cells induced by [Lys1]-VmCT1-NH2 is 120%, 120%, 120%, 110%, 120%, 120%, 115% and 115% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 ¦ÌM. "	Not found	31181304	Eur J Pharm Sci.?2019 Jun 7;136:104952. doi: 10.1016/j.ejps.2019.06.006.	"Pedron CN,?de Oliveira CS,?da Silva AF,?Andrade GP,?da Silva Pinhal MA,?Cerchiaro G,?da Silva Junior PI,?da Silva FD,?Torres MT,?Oliveira VX"	The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1
DRAMP21368	KLGALWNVAKSKF	13	[Lys]1[Lys]12-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"2% Helical content in water, 0% helical content in PBS (pH7.4), 19% helical content in SDS (20 mmol/L), 13% helical content in TFE/Water (3:2, v:v), 0"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans MDM8 and Candida tropicalis IOC 4560.	"[Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=12.5?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=6.3?¦Ìmol/L);##Gram-negative bacteria: Enterobacter cloacae ¦Â-12 (MIC=25¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=6.3?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=3.1?¦Ìmol/L)"	[Ref.31181304] 0% hemolysis at 100 ¦Ìmol/L against human red blood cells	Linear	Free	Amidation	None	L	"[Ref.31181304] The cell viability of MCF-7 cells induced by [Lys1][Lys12]-VmCT1-NH2 is 105%, 110%, 95%, 100%, 110%, 120%, 120% and 120% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 ¦ÌM. "	Not found	31181304	Eur J Pharm Sci.?2019 Jun 7;136:104952. doi: 10.1016/j.ejps.2019.06.006.	"Pedron CN,?de Oliveira CS,?da Silva AF,?Andrade GP,?da Silva Pinhal MA,?Cerchiaro G,?da Silva Junior PI,?da Silva FD,?Torres MT,?Oliveira VX"	The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1
DRAMP21369	FLKALWKVAKSVF	13	[Lys]3[Lys]7-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"0% Helical content in water, 5% helical content in PBS (pH7.4), 37% helical content in SDS (20 mmol/L), 52% helical content in TFE/Water (3:1, v:v), 0"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans MDM8 and Candida tropicalis IOC 4560.	"[Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=0.4?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=0.4?¦Ìmol/L), Staphylococcus epidermidis ATCC 12228 (MIC=3.1?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=1.6?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.1?¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=3.1?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=0.8?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.4?¦Ìmol/L)"	"[Ref.31181304] 15% hemolysis at 3.1 ¦Ìmol/L, 45% hemolysis at 6.3 ¦Ìmol/L, 65% hemolysis at 12.5 ¦Ìmol/L, 85% hemolysis at 25 ¦Ìmol/L, 90% hemolysis at 100 ¦Ìmol/L against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31181304] ¢ÙThe cell viability of MCF-7 cells induced by [Lys3][Lys7]-VmCT1-NH2 is 95%, 95%, 90%, 85%, 80%, 70%, 50%, 40% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 ¦ÌM. ¢ÚThe cell viability of MCF-10A cells induced by [Lys3][Lys7]-VmCT1-NH2 is 120%, 120%, 120%,120%, 95% and 90% at peptide concentrations of 0.8, 1.6, 3.1, 6.3, 12.5 and 25 ¦ÌM."	Not found	31181304	Eur J Pharm Sci.?2019 Jun 7;136:104952. doi: 10.1016/j.ejps.2019.06.006.	"Pedron CN,?de Oliveira CS,?da Silva AF,?Andrade GP,?da Silva Pinhal MA,?Cerchiaro G,?da Silva Junior PI,?da Silva FD,?Torres MT,?Oliveira VX"	The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1
DRAMP21370	FLKALWNVAKKVF	13	[Lys]3[Lys]11-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"0% Helical content in water, 4% helical content in PBS (pH7.4), 28% helical content in SDS (20 mmol/L), 33% helical content in TFE/Water (3:2, v:v), 2"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans MDM8 and Candida tropicalis IOC 4560.	"[Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=0.8?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=0.4?¦Ìmol/L), Staphylococcus epidermidis ATCC 12228 (MIC=1.6?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=1.6?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.2?¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=3.1?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=1.6?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.4?¦Ìmol/L)"	"[Ref.31181304] 40% hemolysis at 12.5 ¦Ìmol/L, 70% hemolysis at 25 ¦Ìmol/L, 80% hemolysis at 50 ¦Ìmol/L against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31181304] ¢ÙThe cell viability of MCF-7 cells induced by [Lys3][Lys11]-VmCT1-NH2 is 95%, 100%, 80%, 80%, 55%, 45%, 20% and 20% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 ¦ÌM. ¢ÚThe cell viability of MCF-10A cells induced by [Lys3][Lys11]-VmCT1-NH2 is 120%, 120%, 90%, 100%, 120% and 95%  at  peptide concentrations of 0.8, 1.6, 3.1, 6.3, 12.5 and 25 ¦ÌM."	Not found	31181304	Eur J Pharm Sci.?2019 Jun 7;136:104952. doi: 10.1016/j.ejps.2019.06.006.	"Pedron CN,?de Oliveira CS,?da Silva AF,?Andrade GP,?da Silva Pinhal MA,?Cerchiaro G,?da Silva Junior PI,?da Silva FD,?Torres MT,?Oliveira VX"	The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1
DRAMP21371	FLGALWKVAKKVF	13	[Lys]7[Lys]11-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"0% Helical content in water, 3% helical content in PBS (pH7.4), 27% helical content in SDS (20 mmol/L), 39% helical content in TFE/Water (3:2, v:v), 1"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans MDM8 and Candida tropicalis IOC 4560.	"[Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=0.8?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=0.4?¦Ìmol/L), Staphylococcus epidermidis ATCC 12228 (MIC=6.3?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=3.1?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.2?¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=3.1?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=1.6?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.4¦Ìmol/L)"	"[Ref.31181304] 45% hemolysis at 12.5 ¦Ìmol/L, 100% hemolysis at 50 ¦Ìmol/L against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31181304] ¢ÙThe cell viability of MCF-7 cells induced by [Lys7][Lys11]-VmCT1-NH2 is 105%, 105%, 95%, 85%, 65%, 45%, 25% and 25% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 ¦ÌM. ¢ÚThe cell viability of MCF-10A cells induced by [Lys7][Lys11]-VmCT1-NH2 is 120%, 120%, 85%, 90%, 120% and 120%at peptide concentrations of 0.8, 1.6, 3.1, 6.3, 12.5 and 25 ¦ÌM."	Not found	31181304	Eur J Pharm Sci.?2019 Jun 7;136:104952. doi: 10.1016/j.ejps.2019.06.006.	"Pedron CN,?de Oliveira CS,?da Silva AF,?Andrade GP,?da Silva Pinhal MA,?Cerchiaro G,?da Silva Junior PI,?da Silva FD,?Torres MT,?Oliveira VX"	The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1
DRAMP21372	FLKALWKVAKKVF	13	[Lys]3[Lys]7[Lys]11-VmCT1-NH2 (Derived from VmCT1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	"0% Helical content in water, 3% helical content in PBS (pH7.4), 25% helical content in SDS (20 mmol/L), 23% helical content in TFE/Water (3:2, v:v), 2"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans MDM8 and Candida tropicalis IOC 4560.	"[Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4?¦Ìmol/L), Staphylococcus aureus ATCC 29213 (MIC=0.8?¦Ìmol/L), Bacillus megaterium ATCC 10778 (MIC=0.2?¦Ìmol/L), Staphylococcus epidermidis ATCC 12228 (MIC=3.1?¦Ìmol/L);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=1.6?¦Ìmol/L)£¬Serratia marcescens ATCC 4112 (MIC=0.1¦Ìmol/L), Enterobacter cloacae ¦Â-12 (MIC=3.1?¦Ìmol/L);##Fungi: Candida albicans MDM8 (MIC=0.8?¦Ìmol/L), Candida tropicalis IOC 4560 (MIC=0.4¦Ìmol/L)"	"[Ref.31181304] 40% hemolysis at 12.5 ¦Ìmol/L, 60% hemolysis at 25 ¦Ìmol/L, 80% hemolysis at 50 ¦Ìmol/L, 100% hemolysis at 100 ¦Ìmol/L against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31181304] ¢ÙThe cell viability of MCF-7 cells induced by [Lys3][Lys7][Lys11]-VmCT1-NH2 is 90%, 90%, 90%, 60%, 50%, 30%, 20% and 20% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 ¦ÌM. ¢ÚThe cell viability of MCF-10A cells induced by [Lys3][Lys7][Lys11]-VmCT1-NH2 is 120%, 120%, 85%, 120%, 115% and 120%at peptide concentrations of 0.8, 1.6, 3.1, 6.3, 12.5 and 25 ¦ÌM."	Not found	31181304	Eur J Pharm Sci.?2019 Jun 7;136:104952. doi: 10.1016/j.ejps.2019.06.006.	"Pedron CN,?de Oliveira CS,?da Silva AF,?Andrade GP,?da Silva Pinhal MA,?Cerchiaro G,?da Silva Junior PI,?da Silva FD,?Torres MT,?Oliveira VX"	The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1
DRAMP21373	AIKIRKLFKKLLR	13	SP1 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=12.5¨C25 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP1 is 87.8%, 88.5%, 83.1%, 95.3%, 97.3% and 68.9% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21374	GIKIRKLFKKLLR	13	SP2 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=6.25¨C12.5 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP2 is 108.8%, 110.1%, 116.9%, 104.7%, 108.8% and 83.1% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21375	GWAKLITKAIKKI	13	SP3 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=25¨C50 ?g/mL)	[Ref.31163671] 10% hemolysis at 50¨C100 ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP3 is 80.4%, 77.0%, 87.8%, 98.0%, 76.4% and 84.5% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21376	GIKFFLKKLKKHI	13	SP4 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=25¨C50 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP4 is 102.0%, 114.2%, 100.7%, 93.2%, 108.1% and 83.1% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21377	IRPAKLRWFKKIK	13	SP5 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC >100 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP5 is 110.8%, 100.7%, 104.7%, 110.1%, 87.8% and 90.5% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21378	RLFIKKLKFITRR	13	SP6 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=25¨C50 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP6 is 92.6%, 100%, 102.7%, 106.8%, 93.2% and 99.3% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21379	NAMRGAKRVWRHI	13	SP7 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC >100 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP7 is 91.9%, 95.9%, 103.4%, 94.6%, 93.9% and 91.2% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21380	KFRKFGKQVWVRL	13	SP8 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=12.5¨C25 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP8 is 98.0%, 104.7%, 98.0%, 103.4%, 93.2%, 92.6% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21381	aikirklfkkllr	13	SP1D * (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=12.5¨C25 ?g/mL)	[Ref.31163671] 10% hemolysis at 25¨C50 ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	D	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP1D is 80.4%, 102.0%, 81.8%, 81.8%, 74.3% and 66.2% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21382	KVWSRLRKIFSTR	13	SP9 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=6.25¨C12.5 ?g/mL)	[Ref.31163671] 10% hemolysis at 50¨C100 ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP9 is 104.7%, 110.8%, 108.8%, 108.8%, 97.3% and 79.1% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21383	AKVLKISRRAFRK	13	SP10 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC >100 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP10 is 114.2%, 82.4%, 94.6%, 98.6%, 103.4% and 98.6% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21384	IRRWRLHWFRRAI	13	SP11 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=12.5¨C25 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP11 is 95.3%, 109.5%, 108.1%, 89.2%, 112.8% and 81.1% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21385	IRRRIRLIVRRQI	13	SP12 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=12.5¨C25 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP12 is 98.0%, 99.3%, 95.9%, 92.6%, 100% and 89.2% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21386	HFKIRKRFVKKLV	13	SP13 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC >100 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP13 is 104.1%, 106.8%, 111.5%, 101.4%, 107.4%, 118.2% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21387	RWIRWVWRKKLRI	13	SP14 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=12.5¨C25 ?g/mL)	[Ref.31163671] 10% hemolysis at 50¨C100 ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP14 is 102.7%, 95.3%, 88.5%, 93.9%, 100% and 98.6% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21388	RWIRWVWRKKLR	12	SP15 * (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC= 3.125¨C6.25 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	L	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP15 is 90.5%, 90.5%, 89.2%, 83.1%, 93.2% and 52.7% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21389	rwirwvwrkklr	12	SP15D * (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix mainly	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=0.78¨C1.56 ?g/mL)	[Ref.31163671] 10% hemolysis at >100  ¦Ìg/mL against human blood cells.	Linear	Free	Amidation	None	D	"[Ref.31163671] The cell viability of Hepa 1-6 induced by SP15D is 91.2%, 96.6%, 96.6%, 73.6%, 58.1% and 25% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ¦Ìg/mL."	Not found	31163671	Pharmaceuticals (Basel).?2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.	"Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava and Malak Pirtskhalava"	De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.
DRAMP21390	RWKRHISEQLRRRDRLQR	18	K17 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=45.5-91 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC>120¦ÌM), Pseudomonas aeruginosa (MIC>120¦ÌM);##Fungi: Candida albicans (MIC>120¦ÌM)"	"[Ref.31145591] 2% hemolysis at 600 ¦ÌM, 3% hemolysis at 700 ¦ÌM, 4% hemolysis at 800 ¦ÌM, 5% hemolysis at 900 ¦ÌM, 6% hemolysis at 1000 ¦ÌM, against mouse blood cells."	Linear	Free	Free	None	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21391	RWKRHISEQLRRRDRLQRQAF	21	K18 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=28.8-57.6 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=60-120¦ÌM), Pseudomonas aeruginosa (MIC=60-120¦ÌM);##Fungi: Candida albicans (MIC>120¦ÌM)"	"[Ref.31145591] 3% hemolysis at 500¦ÌM, 16% hemolysis at 600 ¦ÌM, 27% hemolysis at 700 ¦ÌM, 38% hemolysis at 800 ¦ÌM, 50% hemolysis at 900 ¦ÌM, 62% hemolysis at 1000¦ÌM against mouse blood cells."	Linear	Free	Free	None	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21392	RWKRHISEQLRRRDRLQRQAJ	21	K22 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=14.4-28.8 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=30-60¦ÌM), Pseudomonas aeruginosa (MIC=60-120¦ÌM);##Fungi: Candida albicans (MIC=60-120¦ÌM)"	"[Ref.31145591] 3% hemolysis at 500¦ÌM, 10% hemolysis at 600 ¦ÌM, 13% hemolysis at 700 ¦ÌM, 17% hemolysis at 800 ¦ÌM, 20% hemolysis at 900 ¦ÌM, 25% hemolysis at 1000¦ÌM against mouse blood cells."	Linear	Free	Free	The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue.	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21393	RWKRHISEQLRRRDRLQRQAJ	21	K22.2 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=4-8 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=17.5-35¦ÌM), Pseudomonas aeruginosa (MIC=17.5-35¦ÌM);##Fungi: Candida albicans (MIC=60-120¦ÌM)"	"[Ref.31145591] 3% hemolysis at 500¦ÌM, 5% hemolysis at 600 ¦ÌM, 10% hemolysis at 700 ¦ÌM, 15% hemolysis at 800 ¦ÌM, 17% hemolysis at 900 ¦ÌM, 20% hemolysis at 1000¦ÌM against mouse blood cells."	Linear	Free	"Amidation (2-Nal, position 21)"	The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue.	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21394	RWKRHISEQLRRRDRLQRQAJ	21	K30 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Helix¨Cloop¨Chelix in the presence of anionic membrane lipids mimicking bacterial membranes.	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=0.9-1.8 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=6.4-12.8¦ÌM), Pseudomonas aeruginosa (MIC=13.5-27¦ÌM);##Fungi: Candida albicans (MIC=30-60¦ÌM)"	"[Ref.31145591] 3% hemolysis at 600¦ÌM, 4% hemolysis at 700 ¦ÌM, 5% hemolysis at 800 ¦ÌM, 6% hemolysis at 900 ¦ÌM, 9% hemolysis at 1000 ¦ÌM,against mouse blood cells."	Linear	Acylation (Arg1 conjugated with 4-methylhexanoyl group)	"Amidation (2-Nal, position 21)"	The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue.	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21395	RWKRHISEQLRRRDRLQRQAJ	21	K31 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=1.8-3.2 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=3.2-6.4¦ÌM), Pseudomonas aeruginosa (MIC=3.2-6.4¦ÌM);##Fungi: Candida albicans (MIC=3.2-6.4¦ÌM)"	"[Ref.31145591] 50% hemolysis at 10¦ÌM, 70% hemolysis at 61¦ÌM, 75% hemolysis at 100 ¦ÌM, 80% hemolysis at 200 ¦ÌM, 85% hemolysis at 300 ¦ÌM, 90% hemolysis at 900 ¦ÌM, 92% hemolysis at 500¦ÌM against mouse blood cells."	Linear	Acylation (Arg1 conjugated with myristoyl group)	"Amidation (2-Nal, position 21)"	The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue.	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21396	RWKRHISEQLRRRDRLQRQAJ	21	K33 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=1.8-3.2 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=3.2-6.4¦ÌM), Pseudomonas aeruginosa (MIC=6.4-12.8¦ÌM);##Fungi: Candida albicans (MIC=1.8-3.7¦ÌM)"	"[Ref.31145591] 75% hemolysis at 10¦ÌM, 97% hemolysis at 123¦ÌM, 100% hemolysis at 500¦ÌM against mouse blood cells."	Linear	Acylation (Arg1 conjugated with palmitoyl group)	"Amidation (2-Nal, position 21)"	The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue.	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21397	RWKRHISEQLRRRDRLQRQAJ	21	K36 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=0.9-1.8 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=3.2-6.4¦ÌM), Pseudomonas aeruginosa (MIC=6.4-12.8¦ÌM);##Fungi: Candida albicans (MIC=15-30¦ÌM)"	"[Ref.31145591] 5% hemolysis at 200¦ÌM, 10% hemolysis at 300 ¦ÌM, 17% hemolysis at 400 ¦ÌM, 23% hemolysis at 500 ¦ÌM, 30% hemolysis at 600¦ÌM, 32% hemolysis at 700 ¦ÌM, 35% hemolysis at 800 ¦ÌM, 40% hemolysis at 900 ¦ÌM, 42% hemolysis at 1000¦ÌM against mouse blood cells."	Linear	Acylation (Arg1 conjugated with Fmoc group)	"Amidation (2-Nal, position 21)"	The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue.	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21398	RWKRHISEQLRRRDRLQRQAJ	21	K46 (Derived from ATG16)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans.	"[Ref.31145591] Gram-positive bacteria: Staphylococcus aureus(MIC=1.8-3.2 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=3.2-6.4¦ÌM), Pseudomonas aeruginosa (MIC=6.4-12.8¦ÌM);##Fungi: Candida albicans (MIC=30-60¦ÌM)"	"[Ref.31145591] 10% hemolysis at 200¦ÌM, 15% hemolysis at 500¦ÌM, 17% hemolysis at 600 ¦ÌM, 20% hemolysis at 700 ¦ÌM, 25% hemolysis at 800 ¦ÌM, 30% hemolysis at 900 ¦ÌM, 42% hemolysis at 1000¦ÌM against mouse blood cells."	Linear	Acylation (Arg1 conjugated with capryl group)	"Amidation (2-Nal, position 21)"	The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue.	L	[Ref.31145591] No cytotoxicity information found	Not found	31145591	Bioconjug Chem. 2019 Jun 18. doi: 10.1021/acs.bioconjchem.9b00290.	"Varnava KG, Mohid SA, Calligari P, Stella L, Reynison J, Bhunia A, Sarojini V"	"Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide."
DRAMP21400	CGIYRSLKLIKSLVLIK	17	NBC2253 (De Novo Synthesis)?	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	[Ref.31119600] Gram-positive bacteria:MRSA(MIC=6.7 ¡À 0.02?M);##Gram-negative bacteria:Escherichia coli O157:H7(MIC=25 ¡À 0.03?M)	[Ref.31119600] No hemolytic activity against bovine blood cells	Linear	The sulfhydryl side chain of the cysteine residue was conjugated to AuNC(previously modified with SPDP) via a disulfide bond.	Free	None	L	"[Ref.31119600] The cell viability of Vero ATCC CCL 1-81 cells induced by NBC2253 is 87.8%, 66.4%, 62.2%, 69.1% and 68.8% at peptide concentrations of 1.2, 3.7, 11.1, 33.3 and 100 ¦ÌM."	Not found	31119600	Protein J. 2019 May 22. doi: 10.1007/s10930-019-09840-9.	"Prada YA, Guzm¨¢n F, Ort¨ªz C, Cabanzo R, Torres R, Mej¨ªa-Ospino E"	New Synthetic Peptides Conjugated to Gold Nanoclusters: Antibiotic Activity Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA).
DRAMP21401	CALKLTKAKRLVRKIGF	17	NBC2254 (De Novo Synthesis)?	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	[Ref.31119600] Gram-positive bacteria:MRSA(MIC=73 ¡À 0.02?M);##Gram-negative bacteria:Escherichia coli O157:H7(MIC=3.5 ¡À 0.05?M)	[Ref.31119600] No hemolytic activity against bovine blood cells	Linear	The sulfhydryl side chain of the cysteine residue was conjugated to AuNC(previously modified with SPDP) via a disulfide bond.	Free	None	L	"[Ref.31119600] The cell viability of Vero ATCC CCL 1-81 cells induced by NBC2254 is 93.7%, 90.1%, 89.5%, 95.9% and 78.6% at peptide concentrations of 1.2, 3.7, 11.1, 33.3 and 100 ¦ÌM."	Not found	31119600	Protein J. 2019 May 22. doi: 10.1007/s10930-019-09840-9.	"Prada YA, Guzm¨¢n F, Ort¨ªz C, Cabanzo R, Torres R, Mej¨ªa-Ospino E"	New Synthetic Peptides Conjugated to Gold Nanoclusters: Antibiotic Activity Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA).
DRAMP21402	KFKKLFKKLSPVFKRIVQRIKDFLR	25	B1 (Derived from LL-37 and BMAP-27)	No entry found	Belongs to the cathelicidin family.	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	88 % of the ¦Á-helices and 12% of the random coil was predicted using HNN	The helicity percentages of the secondary structure of B1 are predicted using HNN	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31118709] Gram-positive bacteria:Staphylococcus aureus ATCC 29213(MIC=20¦ÌM), Staphylococcus aureus ATCC 33591(MIC=20¦ÌM), Staphylococcus aureus ATCC 43300(MIC=20¦ÌM), Staphylococcus aureus ATCC BAA-41(MIC=20¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=20¦ÌM), Escherichia coli 35218 (MIC=20¦ÌM), Pseudomonas aeruginosa BAA-2114 (MIC=10¦ÌM)"	"[Ref.31118709] 0% hemolysis at 10¦ÌM, 8% hemolysis at 25¦ÌM, 19% hemolysis at 50¦ÌM, 23% hemolysis at 75¦ÌM, 30% hemolysis at 100¦ÌM, 38% hemolysis at 125¦ÌM, 40% hemolysis at 150¦ÌM, 43% hemolysis at 175¦ÌM, 50% hemolysis at 200¦ÌM against human blood cells."	Linear	Free	Free	None	L	"[Ref.31118709] The cell viability of HEK293 mammalian cell line induced by B1 is 87.0%, 67.1%, 52.3%, 54.3%, 50.6% and 50% at peptide concentrations of 10, 20, 40, 60, 80 and 100 ¦ÌM."	Not found	31118709	Infect Drug Resist. 2019; 12: 1035¨C1045. Published online 2019 Apr 30. doi:?10.2147/IDR.S199473	"Yara Al Tall, Ahmad Abualhaijaa, Mohammad Alsaggar, Ammar Almaaytah, Majed Masadeh, and Karem H Alzoub"	Design and characterization of a new hybrid peptide from LL-37 and BMAP-27
DRAMP21403	ITEVITILLNRLTDRLEK	18	peptide 1 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM phosphate buffer, pH7.4"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31117348] Gram-positive bacteria:Staphylococcus aureus ATCC 6538(MIC>100¦ÌM), Bacillus subtilis ATCC 6633(MIC>100¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 15597(MIC>100¦ÌM), Pseudomonas aeruginosa (MIC>100¦ÌM), Salmonella Typhimurium 6192(MIC>100¦ÌM), Klebsiella pneumoniae NCTC 5055(MIC>100¦ÌM)"	[Ref.31117348] 5% hemolysis at 250 ¦ÌM against human blood cells.	Linear	Free	Free	None	L	[Ref.31117348] No cytotoxicity information found	Not found	31117348	ACS Infect Dis. 2019 May 30. doi: 10.1021/acsinfecdis.9b00157.	"Hammond K, Lewis H, Faruqui N, Russell C, Hoogenboom BW, Ryadnov MG"	Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics.
DRAMP21404	ITKVITKLLNRLTKILSK	18	peptide 2 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-helix mainly in 10 mM phosphate buffer, pH7.4"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31117348] Gram-positive bacteria:Staphylococcus aureus ATCC 6538(MIC=15 ¡À 2.5¦ÌM), Bacillus subtilis ATCC 6633(MIC=15 ¡À 2.5¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 15597(MIC=3.1¦ÌM), Pseudomonas aeruginosa (MIC=25¦ÌM), Salmonella Typhimurium 6192(MIC=40 ¡À 5¦ÌM), Klebsiella pneumoniae NCTC 5055(MIC=50¦ÌM)"	[Ref.31117348] 5% hemolysis at 250 ¦ÌM against human blood cells.	Linear	Free	Free	None	L	"[Ref.31117348] ¢ÙThe cell viability of MCF7 cells induced by peptide 2 is 94.2%, 88.6%, 82.0%, 55.0%, 44.0%, 32.4%, 15.3%, 15.8%, 12.8% and 1.2% at peptide concentrations of 1, 10, 15, 20, 25, 30, 35, 40, 50 and 100 ¦ÌM. EC50=22.5¡À0.7 ¦ÌM. ¢ÚThe cell viability of Hela cells induced by peptide 2 is 96.1%, 95.4%, 83.8%, 64.2%, 57.7%, 49.5%, 31.5%, 30.2%, 7.8% and 0.2% at peptide concentrations of 1, 10, 15, 20, 25, 30, 35, 40, 50 and 100 ¦ÌM. EC50=29.8¡À1 ¦ÌM. ¢ÛThe cell viabiity of HDF cells induced by peptide 2 is 96.3%, 89.7%, 89.9%, 92.7%, 95.0%, 93.4%, 93.1%, 96.1%, 88.6% and 67.4% at peptide concentrations of 1, 10, 15, 20, 25, 30, 35, 40, 50 and 100 ¦ÌM."	Not found	31117348	ACS Infect Dis. 2019 May 30. doi: 10.1021/acsinfecdis.9b00157.	"Hammond K, Lewis H, Faruqui N, Russell C, Hoogenboom BW, Ryadnov MG"	Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics.
DRAMP21405	GKIIKLKASLKLL	13	LGL13K (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31071184] Gram-positive bacteria:Staphylococcus aureus Xen36(MIC=83.3¦Ìg/ml), Staphylococcus aureus USA300(Uknow);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=10.4¦Ìg/ml)"	[Ref.31071184] LD50=560¦Ìg/ml against human blood cells	Linear	Free	Amidation	None	L	"[Ref.31071184] The cytotoxicity of L-GL13K on HEK cells is 2.1%, 3.3%, 2.4%, 1.2%24.3%, 51.7% and 73.6% at peptide concentrations of 1, 3.9, 15.6, 62.5, 250 and 1000 ¦Ìg/mL, while the cytotoxicity of PMX on HEK cells (Control samples) is 1.2%, 1.2%, 6.6%, 3.6%, 39.6%, 47.1% and 68.5% at peptide concentrations of 1, 3.9, 15.6, 62.5, 250 and 1000 ¦Ìg/mL."	Not found	31071184	PLoS One. 2019 May 9;14(5):e0216669. doi: 10.1371/journal.pone.0216669. eCollection 2019.	"Gorr SU, Flory CM, Schumacher RJ"	In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K.
DRAMP21406	Gkiiklkaslkll	13	DGL13K (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31071184] Gram-positive bacteria:Staphylococcus aureus Xen36(MIC=2.6¦Ìg/ml), Staphylococcus aureus USA300(MIC=5.2¦Ìg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=5.2¦Ìg/ml)"	[Ref.31071184] LD50=950¦Ìg/ml against human blood cells	Linear	Free	Amidation	None	Mixed (L-Gly1)	"[Ref.31071184] The cytotoxicity of D-GL13K on HEK cells is 1.5%, 0.9%, 2.1%, 1.5%, 34.2%, 32.4% and 41.1% at peptide concentrations of 1, 3.9, 15.6, 62.5, 250 and 1000 ¦Ìg/mL, while the cytotoxicity of PMX on HEK cells (Control samples) is 1.2%, 1.2%, 6.6%, 3.6%, 39.6%, 47.1% and 68.5% at peptide concentrations of 1, 3.9, 15.6, 62.5, 250 and 1000 ¦Ìg/mL."	Not found	31071184	PLoS One. 2019 May 9;14(5):e0216669. doi: 10.1371/journal.pone.0216669. eCollection 2019.	"Gorr SU, Flory CM, Schumacher RJ"	In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K.
DRAMP21407	KLCKIVVIKVCK	12	Bac4K (Derived from CAMPs)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Â-turn	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC>64¦ÌM), Staphylococcus epidermidis (MIC=32¦ÌM), Bacillus subtilis (MIC>64¦ÌM), Enterococcus faecalis (MIC>64¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=8¦ÌM), Salmonella typhimurium (MIC>64¦ÌM), Pseudomonas aeruginosa (MIC>64¦ÌM), Acinetobacter baumannii (MIC>64¦ÌM)"	[Ref.31056261] 0.6% hemolysis at 100?¦ÌM against human red blood cells.	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys11.	L	[Ref.31056261] No cytotoxicity information found	Not found	31056261	Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2	"Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI"	A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.
DRAMP21408	RLCRIWWIRWCR	12	Bac3W (Derived from CAMPs)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Â-turn	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC=16¦ÌM), Staphylococcus epidermidis (MIC=8¦ÌM), Bacillus subtilis (MIC=32¦ÌM), Enterococcus faecalis (MIC=32¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2-4 ¦ÌM), Salmonella typhimurium (MIC=8 ¦ÌM), Pseudomonas aeruginosa (MIC=4¦ÌM), Acinetobacter baumannii (MIC=16-32¦ÌM)"	[Ref.31056261] 0.9% hemolysis at 100?¦ÌM against human red blood cells	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys11.	L	[Ref.31056261] No cytotoxicity information found	Not found	31056261	Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2	"Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI"	A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.
DRAMP21409	ricrivvirvcr	12	dBac (Derived from CAMPs)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Â-turn	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC=16¦ÌM), Staphylococcus epidermidis (MIC=4-8¦ÌM), Bacillus subtilis (MIC=16¦ÌM), Enterococcus faecalis (MIC>64¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=4-8¦ÌM), Salmonella typhimurium (MIC=32-64¦ÌM), Pseudomonas aeruginosa (MIC>64¦ÌM), Acinetobacter baumannii (MIC>64¦ÌM)"	[Ref.31056261] 0.7% hemolysis at 100?¦ÌM against human red blood cells	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys11.	D	[Ref.31056261] No cytotoxicity information found	Not found	31056261	Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2	"Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI"	A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.
DRAMP21410	klckivvikvck	12	dBac4K (Derived from CAMPs)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Â-turn	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC>64¦ÌM), Staphylococcus epidermidis (MIC=8-16¦ÌM), Bacillus subtilis (MIC>64¦ÌM), Enterococcus faecalis (MIC>64¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=4-8¦ÌM), Salmonella typhimurium (MIC=32-64¦ÌM), Pseudomonas aeruginosa (MIC>64¦ÌM), Acinetobacter baumannii (MIC>64¦ÌM)"	[Ref.31056261] 0.7% hemolysis at 100?¦ÌM against human red blood cells	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys11.	D	[Ref.31056261] No cytotoxicity information found	Not found	31056261	Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2	"Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI"	A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.
DRAMP21411	ricriwwirwcr	12	dBac3W (Derived from CAMPs)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Â-turn	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC=16¦ÌM), Staphylococcus epidermidis (MIC=16¦ÌM), Bacillus subtilis (MIC=32¦ÌM), Enterococcus faecalis (MIC=16-32¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=4-8¦ÌM), Salmonella typhimurium (MIC=4-8¦ÌM), Pseudomonas aeruginosa (MIC=4-8¦ÌM), Acinetobacter baumannii (MIC=32¦ÌM)"	[Ref.31056261] 1.0% hemolysis at 100?¦ÌM against human red blood cells	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys11.	D	[Ref.31056261] No cytotoxicity information found	Not found	31056261	Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2	"Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI"	A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.
DRAMP21412	rkcrivvirvcr	12	dBacK (Derived from CAMPs)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Â-turn	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC=4-8¦ÌM), Staphylococcus epidermidis (MIC=1-2¦ÌM), Bacillus subtilis (MIC=1-2¦ÌM), Enterococcus faecalis (MIC=4¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=1-2¦ÌM), Salmonella typhimurium (MIC=1-2¦ÌM), Pseudomonas aeruginosa (MIC=2-4¦ÌM), Acinetobacter baumannii (MIC=2-4¦ÌM)"	[Ref.31056261] 0.6% hemolysis at 100?¦ÌM against human red blood cells	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys11.	D	[Ref.31056261] No cytotoxicity information found	Not found	31056261	Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2	"Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI"	A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.
DRAMP21413	rkcrivvirvcr	12	dBacK- (cap) (Derived from CAMPs)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Â-turn	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC=1-2¦ÌM), Staphylococcus epidermidis (MIC=2¦ÌM), Bacillus subtilis (MIC=2¦ÌM), Enterococcus faecalis (MIC=4-8¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC=2-4¦ÌM), Salmonella typhimurium (MIC=2-4¦ÌM), Pseudomonas aeruginosa (MIC=4-8¦ÌM), Acinetobacter baumannii (MIC=1-2¦ÌM)"	[Ref.31056261] 2.1% hemolysis at 100?¦ÌM against human red blood cells	Cyclic	Free	Free	Disulfide bond between Cys3 and Cys11. The lysine side-chain residue at position 2(Lys2) is conjugated to the capric acid 	D	[Ref.31056261] No cytotoxicity information found	Not found	31056261	Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2	"Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI"	A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.
DRAMP21414	RWKIFKKIEKMGRNIRDGIVKAGPAIQVLGSAKAI	35	CecB Q53 (Derived from CecB E53)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Random coil in aqueous solution and amphipathic helix upon interaction with cell membranes	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria. Antifungal activity against Candida albicans ATCC 1023.	"[Ref.31045339] Gram-positive bacteria: Staphylococcus aureus ATCC BAA-44(MIC>20¦ÌM), Staphylococcus epidermidis ATCC 700565(MIC=8¦ÌM);##Gram-negative bacteria:  Escherichia coli ATCC 25922 (MIC=0.15¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC=2.2¦ÌM), Pseudomonas aeruginosa ATCC 25668(MIC=2.2¦ÌM);##Fungi:Candida albicans ATCC 1023(MIC>20¦ÌM)"	"[Ref.31045339] 0.1% hemolysis at 20¦ÌM, 0.5% hemolysis at 30¦ÌM, 0.5% hemolysis at 200¦ÌM against human red blood cells"	Linear	Free	Amidation	None	L	"[Ref.31045339] ¢ÙThe cell viability of Hela cells induced by CecB Q53 is 102.6%, 104.0%, 99.1% and 95.6% at peptide concentrations of 10, 20, 30 and 200 ¦ÌM. ¢ÚThe cell viability of CCD cells induced by CecB Q53 is 108.4%, 111.5%, 108.8% and 88.5% at peptide concentrations of 10, 20, 30 and 200 ¦ÌM."	Not found	31045339	ACS Infect Dis. 2019 May 10. doi: 10.1021/acsinfecdis.9b00042.	"Romoli O, Mukherjee S, Mohid SA, Dutta A, Montali A, Franzolin E, Brady D, Zito F, Bergantino E, Rampazzo C, Tettamanti G, Bhunia A, Sandrelli F"	Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation.
DRAMP21415	LKKWWKTSKGLLGGLLGKVTSVIK	24	¦Á4-short (Derived from ¦Á4)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30967458] Gram-positive bacteria: Staphylococcus aureus 467-1 (MIC=2¦ÌM), Staphylococcus aureus 0154-17 (MIC=2¦ÌM), Staphylococcus aureus 187-10 (MIC=16¦ÌM), Staphylococcus aureus 0194-19 (MIC=2¦ÌM), Staphylococcus aureus US300 (MIC=8¦ÌM), Staphylococcus aureus 122-12 (MIC=2¦ÌM), Enterococcus faecium 23614 (MIC=1¦ÌM), Enterococcus faecium 14678 (MIC=1¦ÌM), Enterococcus faecium 26125 (MIC=1¦ÌM);##Gram-negative bacteria:Pseudomonas aeruginosa 16-21 (MIC=2¦ÌM), Pseudomonas aeruginosa 16-72 (MIC=2¦ÌM), Pseudomonas aeruginosa 16-73 (MIC=2¦ÌM), Pseudomonas aeruginosa 0038-13 (MIC=2¦ÌM), Pseudomonas aeruginosa 0038-14 (MIC=1¦ÌM), Pseudomonas aeruginosa 0040-21 (MIC=2¦ÌM), Pseudomonas aeruginosa 0046-106 (MIC=8¦ÌM), Pseudomonas aeruginosa 0068-37 (MIC=16¦ÌM), Pseudomonas aeruginosa 0071-75 (MIC=2¦ÌM), Pseudomonas aeruginosa 97-5 (MIC=2¦ÌM), Pseudomonas aeruginosa 109-10 (MIC=2¦ÌM), Pseudomonas aeruginosa 16-21 (MIC=2¦ÌM)Pseudomonas aeruginosa 132-37 (MIC=2¦ÌM), Pseudomonas aeruginosa 129-5 (MIC=2¦ÌM), Pseudomonas aeruginosa 152-19 (MIC=2¦ÌM), Pseudomonas aeruginosa 159-30 (MIC=2¦ÌM), Pseudomonas aeruginosa 474-1 (MIC=2¦ÌM), Acinetobacter baumannii C3 (MIC=1¦ÌM), Acinetobacter baumannii D4 (MIC=2¦ÌM), Acinetobacter baumannii A2 (MIC=4¦ÌM), Escherichia coli YDC518 (MIC=1¦ÌM), Escherichia coli YDC575 (MIC=2¦ÌM), Escherichia coli YDC596 (MIC=1¦ÌM), Escherichia coli YDC107 (MIC=1¦ÌM), Escherichia coli YDC337 (MIC=1¦ÌM), Escherichia coli YDC748 (MIC=1¦ÌM), Klebsiella pneumoniae A2 (MIC=4¦ÌM), Klebsiella pneumoniae D4 (MIC=2¦ÌM), Klebsiella pneumoniae 438-16 (MIC=4¦ÌM)"	"[Ref.30967458] 1% hemolysis at 17?¦ÌM, 2% hemolysis at 30?¦ÌM, 3% hemolysis at 63?¦ÌM against human red blood cells"	Linear	Free	Free	None	L	"[Ref.30967458] The white blood cell toxicity of ¦Á4-short is ~0%, ~0%, ~0%, ~0%, ~0%, 1.8% and 3.1% at peptide concentrations of 1, 2, 4, 8, 16, 32 and 64 ¦ÌM."	Not found	30967458	mBio. 2019 Mar-Apr; 10(2): e00226-19. Published online 2019 Apr 9. doi:?10.1128/mBio.00226-19	"Shasha Jiang, Berthony Deslouches, Chen Chen, Matthew E. Di, Y. Peter Di"	"Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, ¦Á6-Short, in a Murine Model of Respiratory Infection"
DRAMP21416	WVKAAAKAAAKVW	13	WV (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-helix predicted by I-TASSER, random coil in PBS, ¦Á-helix in SDS"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30897850] Gram-positive bacteria:Staphylococcus aureus ATCC 27853(MIC>128¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC>128¦ÌM), Staphylococcus faecalis ATCC 29212(MIC=64¦ÌM), Bacillus subtilis CMCC 63501(MIC>128¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=32¦ÌM), Escherichia coli UB 1005 (MIC>128¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC>128¦ÌM), Salmonella typhimurium ATCC 14028(MIC>128¦ÌM)"	[Ref.30897850] 1.5% hemolysis at 256¦ÌM against human red blood cells	Linear	Free	Amidaton	None	L	"[Ref.30897850] ¢ÙThe cell viability of RAW 264.7 induced by WV is 102.5%, 93.5%, 97.8%, 95.7%, 99.3%, 99.6%, 93.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM, while the cytotoxicity of WV on RAW 264.7 cells (Control samples) is 93.1%, 67.8%, 37.7%, 17.8%, 0%, 1.4% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM.¢ÚThe cell viability of HEK293T induced by WV is 115.2%, 104.3%, 114.5%, 107.6%, 105.8%, 108.0% and 93.8% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM, while the cytotoxicity of WV on HEK293T cells (Control samples) is 101.4%, 80.1%, 31.9%, 1.4%, 1.4%, 1.8% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM."	Not found	30897850	Int J Mol Sci. 2019 Mar; 20(6): 1417. Published online 2019 Mar 20. doi:?10.3390/ijms20061417	"Changxuan Shao, Weizhong Li, Peng Tan, Anshan Shan, Xiujing Dou, Deying Ma, Chunyu Liu"	Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency
DRAMP21417	WIKAAAKAAAKIW	13	WI (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-helix predicted by I-TASSER, random coil in PBS, ¦Á-helix in SDS"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30897850] Gram-positive bacteria:Staphylococcus aureus ATCC 27853(MIC=32¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=32¦ÌM), Staphylococcus faecalis ATCC 29212(MIC=32¦ÌM), Bacillus subtilis CMCC 63501(MIC=8¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=8¦ÌM), Escherichia coli UB 1005 (MIC=8¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC=32¦ÌM), Salmonella typhimurium ATCC 14028(MIC=32¦ÌM)"	[Ref.30897850] 15% hemolysis at 256¦ÌM against human red blood cells	Linear	Free	Amidaton	None	L	"[Ref.30897850] ¢ÙThe cell viability of RAW 264.7 induced by WI is 104.0%, 98.2%, 98.6%, 106.5%, 103.6%, 101.8% and 100% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM, while the cytotoxicity of WV on RAW 264.7 cells (Control samples) is 93.1%, 67.8%, 37.7%, 17.8%, 0%, 1.4% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM.¢ÚThe cell viability of HEK293T induced by WV is 98.9%, 99.3%, 107.2%, 99.6%, 110.5%, 108.3%, 96.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM, while the cytotoxicity of WV on HEK293T cells (Control samples) is 101.4%, 80.1%, 31.9%, 1.4%, 1.4%, 1.8% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM."	Not found	30897850	Int J Mol Sci. 2019 Mar; 20(6): 1417. Published online 2019 Mar 20. doi:?10.3390/ijms20061417	"Changxuan Shao, Weizhong Li, Peng Tan, Anshan Shan, Xiujing Dou, Deying Ma, Chunyu Liu"	Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency
DRAMP21418	WFKAAAKAAAKFW	13	WF (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-helix predicted by I-TASSER, random coil in PBS, ¦Á-helix in SDS"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30897850] Gram-positive bacteria:Staphylococcus aureus ATCC 27853(MIC=8¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=16¦ÌM), Staphylococcus faecalis ATCC 29212(MIC=32¦ÌM), Bacillus subtilis CMCC 63501(MIC=8¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=4¦ÌM), Escherichia coli UB 1005 (MIC=4¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC=16¦ÌM), Salmonella typhimurium ATCC 14028(MIC=32¦ÌM)"	[Ref.30897850] 12% hemolysis at 256¦ÌM against human red blood cells	Linear	Free	Amidaton	None	L	"[Ref.30897850] ¢ÙThe cell viability of RAW 264.7 induced by WF is 102.5%, 103.6%, 105.4%, 108.3%, 105.8%, 101.1% and 92.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM, while the cytotoxicity of WV on RAW 264.7 cells (Control samples) is 93.1%, 67.8%, 37.7%, 17.8%, 0%, 1.4% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM.¢ÚThe cell viability of HEK293T induced by WV is 101.8%, 101.4%, 93.5%, 97.1%, 93.8%, 107.6% and 92.0% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM, while the cytotoxicity of WV on HEK293T cells (Control samples) is 101.4%, 80.1%, 31.9%, 1.4%, 1.4%, 1.8% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM."	Not found	30897850	Int J Mol Sci. 2019 Mar; 20(6): 1417. Published online 2019 Mar 20. doi:?10.3390/ijms20061417	"Changxuan Shao, Weizhong Li, Peng Tan, Anshan Shan, Xiujing Dou, Deying Ma, Chunyu Liu"	Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency
DRAMP21419	WWKAAAKAAAKWW	13	WW (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-helix predicted by I-TASSER, random coil in PBS, ¦Á-helix in SDS"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30897850] Gram-positive bacteria:Staphylococcus aureus ATCC 27853(MIC=4¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=4¦ÌM), Staphylococcus faecalis ATCC 29212(MIC=4¦ÌM), Bacillus subtilis CMCC 63501(MIC=4¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=2¦ÌM), Escherichia coli UB 1005 (MIC=4¦ÌM), Pseudomonas aeruginosa ATCC 27853(MIC=8¦ÌM), Salmonella typhimurium ATCC 14028(MIC=8¦ÌM)"	[Ref.30897850] 24% hemolysis at 256¦ÌM against human red blood cells	Linear	Free	Amidaton	None	L	"[Ref.30897850] ¢ÙThe cell viability of RAW 264.7 induced by WW is 104.3%, 103.6%, 109.4%, 103.6%, 97.5%, 89.9%, 63.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM, while the cytotoxicity of WV on RAW 264.7 cells (Control samples) is 93.1%, 67.8%, 37.7%, 17.8%, 0%, 1.4% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM.¢ÚThe cell viability of HEK293T induced by WV is 102.9%, 111.6%, 105.1%, 104.3%, 101.8%, 84.8%, 43.5% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM, while the cytotoxicity of WV on HEK293T cells (Control samples) is 101.4%, 80.1%, 31.9%, 1.4%, 1.4%, 1.8% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 ¦ÌM."	Not found	30897850	Int J Mol Sci. 2019 Mar; 20(6): 1417. Published online 2019 Mar 20. doi:?10.3390/ijms20061417	"Changxuan Shao, Weizhong Li, Peng Tan, Anshan Shan, Xiujing Dou, Deying Ma, Chunyu Liu"	Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency
DRAMP21420	FLPKLFAKITKKNMAHIRC	19	AY1C (Derived from AY1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Helix-loop-helix derived from NMR	Not found	5YKL resolved by NMR	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.30872680] Gram-negative bacteria:Pseudomonas aeruginosa (MIC=15¦ÌM), Escherichia coli  (MIC=17¦ÌM), Salmonella typhi(MIC=15¦ÌM), Klebsiella pneumoniae(MIC=12¦ÌM)"	"[Ref.30872680] 4% hemolysis at 10?¦ÌM, 9% hemolysis at 50?¦ÌM, 8% hemolysis at 100¦ÌM against human red blood cells"	Linear	Free	Free	None	L	[Ref.30872680] No cytotoxicity information found.	Not found	30872680	Sci Rep. 2019; 9: 4485. Published online 2019 Mar 14. doi:?10.1038/s41598-019-41005-7	"Pal I, Bhattacharyya D, Kar RK, Zarena D, Bhunia A, Atreya HS"	A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria
DRAMP21421	FLPKLFAKITKKNMAHIRC	19	AY1C-AgNP (Derived from AY1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Helix-loop-helix derived from NMR	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.30872680] Gram-negative bacteria:Pseudomonas aeruginosa (MIC=15¦ÌM), Escherichia coli  (MIC=12¦ÌM), Salmonella typhi(MIC=15¦ÌM), Klebsiella pneumoniae(MIC=10¦ÌM)"	"[Ref.30872680] 4% hemolysis at 10?¦ÌM, 6% hemolysis at 50?¦ÌM, 9% hemolysis at 100¦ÌM against human red blood cells"	Linear	Free	Free	Conjugation with silver nanoparticles	L	[Ref.30872680] No cytotoxicity information found.	Not found	30872680	Sci Rep. 2019; 9: 4485. Published online 2019 Mar 14. doi:?10.1038/s41598-019-41005-7	"Pal I, Bhattacharyya D, Kar RK, Zarena D, Bhunia A, Atreya HS"	A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria
DRAMP21422	CFLPKLFAKITKKNMAHIR	19	CAY1 (Derived from AY1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Helix-loop-helix derived from NMR	Not found	5YKQ resolved by NMR	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.30872680] Gram-negative bacteria:Pseudomonas aeruginosa (MIC=10¦ÌM), Escherichia coli  (MIC=10¦ÌM), Salmonella typhi(MIC=Not know), Klebsiella pneumoniae(MIC=7¦ÌM)"	"[Ref.30872680] 4% hemolysis at 10?¦ÌM, 9% hemolysis at 50?¦ÌM, 10% hemolysis at 100¦ÌM against human red blood cells"	Linear	Free	Free	None	L	[Ref.30872680] No cytotoxicity information found.	Not found	30872680	Sci Rep. 2019; 9: 4485. Published online 2019 Mar 14. doi:?10.1038/s41598-019-41005-7	"Pal I, Bhattacharyya D, Kar RK, Zarena D, Bhunia A, Atreya HS"	A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria
DRAMP21423	CFLPKLFAKITKKNMAHIR	19	CAY1-AgNP (Derived from AY1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Helix-loop-helix derived from NMR	Not found	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.30872680] Gram-negative bacteria:Pseudomonas aeruginosa (MIC=10¦ÌM), Escherichia coli  (MIC=10¦ÌM), Salmonella typhi(MIC=15¦ÌM), Klebsiella pneumoniae(MIC=5¦ÌM)"	"[Ref.30872680] 3% hemolysis at 10?¦ÌM, 9% hemolysis at 50?¦ÌM, 9.5% hemolysis at 100¦ÌM against human red blood cells"	Linear	Free	Free	Conjugation with silver nanoparticles	L	[Ref.30872680] No cytotoxicity information found.	Not found	30872680	Sci Rep. 2019; 9: 4485. Published online 2019 Mar 14. doi:?10.1038/s41598-019-41005-7	"Pal I, Bhattacharyya D, Kar RK, Zarena D, Bhunia A, Atreya HS"	A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria
DRAMP21424	KKGKGGG	7	B1 (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coils most likely	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=2-4?g/ml), MSSA ATCC 29213(MIC=8-16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=8-16?g/ml)"	"[Ref.30842436] EC10=64¦ÌM, EC50=230¦ÌM, 32% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	¢ÙResidue 3 is N-butylglycine. ¢ÚResidue 5 and residue 7 are  N-1-naphthylmethylglycine. ¢ÛResidue 6 is N-4-methylbenzylglycine. 	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21425	KKGKGGG	7	peptide 2 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=4?g/ml), MSSA ATCC 29213(MIC=8-16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	[Ref.30842436] < 8% hemolysis at 150 ?M against human red blood cells	Linear	Free	Amidation	¢ÙResidue 3 is N-butylglycine. ¢ÚResidue 5 and residue 7 are N-1-naphthylmethylglycine. ¢ÛResidue 6 is N-benzylglycine resembling Phe.	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21426	KKKGGGG	7	peptide 3 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=4?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	[Ref.30842436] < 8% hemolysis at 150 ?M against human red blood cells	Linear	Free	Amidation	¢ÙResidue 4 is N-butylglycine. ¢ÚResidue 5 and residue 7 are N-1-naphthylmethylglycine. ¢ÛResidue 6 is N-benzylglycine resembling Phe. 	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21427	GGGGKKK	7	peptide 4 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=8?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	"[Ref.30842436] EC10=54¦ÌM, 24% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	¢ÙResidue 1 and residue 3 are  N-1-naphthylmethylglycine.¢ÚResidue 2 is N-benzylglycine resembling Phe.¢ÛResidue 4 is N-butylglycine. 	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21428	GGGKGKK	7	peptide 5 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=8?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	[Ref.30842436] < 8% hemolysis at 150 ?M against human red blood cells	Linear	Free	Amidation	¢ÙResidue 1 and residue 3 are  N-1-naphthylmethylglycine.¢ÚResidue 2 is N-benzylglycine resembling Phe.¢ÛResidue 5 is N-butylglycine. 	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21429	KKLKAFA	7	peptide 6 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=8?g/ml), MSSA ATCC 29213(MIC=32?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=8?g/ml)"	"[Ref.30842436] EC10=5¦ÌM, EC50=58¦ÌM, 96% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 1-naphthylmethylglycine	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21430	KKKLAFA	7	peptide 7 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=8?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=16?g/ml)"	"[Ref.30842436] EC10=8¦ÌM, EC50=140¦ÌM, 55% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 1-naphthylmethylglycine	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21431	KKLKAFA	7	peptide 8 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=8?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	"[Ref.30842436] EC10=56¦ÌM, 34% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 2-naphthylmethylglycine	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21432	KKKLAFA	7	peptide 9 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=8?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=16?g/ml)"	"[Ref.30842436] EC10=46¦ÌM, 39% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 2-naphthylmethylglycine	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21433	AFAKLKK	7	peptide 10 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=8-16?g/ml), MSSA ATCC 29213(MIC=16-32?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=64?g/ml)"	[Ref.30842436] < 8% hemolysis at 150 ?M against human red blood cells	Linear	Free	Amidation	Residue 1 and residue 3 are 1-naphthylmethylglycine	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21434	AFAKLKK	7	peptide 11 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=4-8?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=64?g/ml)"	[Ref.30842436] < 8% hemolysis at 150 ?M against human red blood cells	Linear	Free	Amidation	Residue 1 and residue 3 are 2-naphthylmethylglycine	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21437	KKlKafa	7	peptide 14 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=4-8?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=16-32?g/ml)"	"[Ref.30842436] EC10=28¦ÌM, EC50=128¦ÌM, 58% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 1-naphthylmethylglycine	"Mixed (D-Leu3, D-Ala5, D-Phe6 and D-Ala7)"	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21438	KKKlafa	7	peptide 15 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=2?g/ml), MSSA ATCC 29213(MIC=8?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=8?g/ml)"	"[Ref.30842436] EC10=8¦ÌM, EC50=40¦ÌM, 88% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 1-naphthylmethylglycine	"Mixed (D-Leu4, D-Ala5, D-Phe6 and D-Ala7)"	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21439	KKKlafa	7	peptide 16 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=2-4?g/ml), MSSA ATCC 29213(MIC=8-16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	"[Ref.30842436] EC10=18¦ÌM, EC50=118¦ÌM, 60% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 2-naphthylmethylglycine	"Mixed (D-Leu4, D-Ala5, D-Phe6 and D-Ala7)"	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21440	KKlKafa	7	peptide 17 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=8?g/ml), MSSA ATCC 29213(MIC=16?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	"[Ref.30842436] EC10=8¦ÌM, 40% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 2-naphthylmethylglycine	"Mixed (D-Leu3, D-Ala5, D-Phe6 and D-Ala7)"	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21444	afalKKK	7	peptide 21 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=16?g/ml), MSSA ATCC 29213(MIC=32?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	[Ref.30842436] < 8% hemolysis at 150 ?M against human red blood cells	Linear	Free	Amidation	Residue 1 and residue 3 are 1-naphthylmethylglycine	"Mixed (D-Ala1, D-Phe2, D-Ala3, D-Leu4)"	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21446	KKKXAFA	7	peptide 23 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coils most likely	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria	"[Ref.30842436] Gram-positive bacteria: MRSP C22963(MIC=2-4 ?g/ml), MSSA ATCC 29213(MIC=32-64 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa(MIC= 8 ?g/ml)"	"[Ref.30842436] EC10=14¦ÌM, EC50=104¦ÌM, 59% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Nle4 is norleucine. Residue 5 and residue 7 are 2-naphthylmethylglycine	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21448	KKKlaya	7	peptide 25 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=2-4?g/ml), MSSA ATCC 29213(MIC=32-64?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=8?g/ml)"	"[Ref.30842436] EC10=38¦ÌM, EC50=138¦ÌM, 53% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 1-naphthylmethylglycine	"Mixed (D-Leu4, D-Ala5, D-Tyr6, D-Ala7)"	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21450	KKKxAYA	7	peptide 27 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria: MRSP C22963(MIC=2-4 ?g/ml), MSSA ATCC 29213(MIC=64 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa(MIC=64 ?g/ml)"	"[Ref.30842436] EC10=3¦ÌM, EC50=56¦ÌM, 54% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Nle4 is norleucine. Residue 5 and residue 7 are 2-naphthylmethylglycine.	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21451	KKKlaya	7	peptide 28 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=2-4?g/ml), MSSA ATCC 29213(MIC=32?g/ml);##Gram-negative bacteria:Pseudomonas aeruginosa(MIC=32?g/ml)"	"[Ref.30842436] EC10=6¦ÌM, EC50=50¦ÌM, 64% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	Residue 5 and residue 7 are 2-naphthylmethylglycine	"Mixed (D-Leu4, D-Ala5, D-Tyr6, D-Ala7)"	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21452	KKKLAFA	7	peptide 29 (Derived from B1)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Unknown	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30842436] Gram-positive bacteria: MRSP C22963(MIC=4-8 ?g/ml), MSSA ATCC 29213(MIC=16-32 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa(MIC=32 ?g/ml)"	"[Ref.30842436] EC10=9¦ÌM, 46% hemolysis at 150 ?M against human red blood cells"	Linear	Free	Amidation	"Residue 5 and residue 7 are 2-naphthylmethylglycine. Residue 1, residue 2 and residue 3 are N-(4-aminobutyl)glycine"	L	[Ref.30842436] No cytotoxicity information found.	Not found	30842436	Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi:?10.1038/s41598-019-39042-3	"Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen"	"Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections"
DRAMP21453	GLPLLISWIKRKRQQGSKKPVPIIYCNRRTGKCQRM	36	Hybrid (Derived from Melittin and thanatin)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	A combination of ¦Á-helix and ¦Â-lamellar	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30701481] Gram-positive bacteria:Staphylococcus aureus(MIC=0.9-1.5¦Ìmol/L), Bacillus subtilis(MIC=0.6-1.2¦Ìmol/L);##Gram-negative bacteria:Escherichia coli JM 109(MIC=0.6-1.2 ¦Ìmol/L), Salmonella typhimurium(MIC=0.3-0.6¦Ìmol/L)"	[Ref.30701481] 0% hemolysis at 45 ¦Ìmol/L and >0% hemolysis at 60 ¦Ìmol/L against sheep blood cells	Linear	Free	Free	None	L	[Ref.30701481] The average inhibitory rate of the hybrid peptide in the SMMC-7721 cells was 19.14%.	Not found	30701481	AMB Express. 2019; 9: 14. Published online 2019 Jan 30. doi:?10.1186/s13568-019-0739-z	"Xiaofeng Jiang, Kun Qian, Guangping Liu, Laiyu Sun, Guoqing Zhou, Jingfen Li, Xinqiang Fang, Haixia Ge, Zhengbing Lv"	Design and activity study of a melittin¨Cthanatin hybrid peptide
DRAMP21454	GILDWGKKVMDWIKDKM	17	"PLP1 (Insects, animals)"	A0A348G6I7	Belongs to the formicidae venom precursor-01 superfamily.	Not found	Odontomachus monticola (Trap-jaw ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	¦Á-helix predicted by Proteus	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria. Antifungal activity against Saccharomyces cerevisiae.	[Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC<3.1¦ÌM);##Gram-negative bacteria:Escherichia coli (MIC<3.1¦ÌM);##Fungi:Saccharomyces cerevisiae (MIC<50¦ÌM)	[Ref.30658410] 0% hemolysis at 50 ¦ÌM against rat blood cells	Linear	Free	Amidation	None	L	[Ref.30658410] No cytotoxicity information found.	Not found	30658410	Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi:?10.3390/toxins11010050	"Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki"	Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components
DRAMP21455	GWGSIFKTVGKMIAKAAVKAAPEAISAMASQNE	33	"PLP2 (Insects, animals)"	A0A348G5V8	Belongs to the formicidae venom precursor-01 superfamily.	Not found	Odontomachus monticola (Trap-jaw ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	¦Á-helix predicted by Proteus	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria. Antifungal activity against Saccharomyces cerevisiae.	[Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC<6.2¦ÌM);##Gram-negative bacteria:Escherichia coli (MIC<6.2¦ÌM);##Fungi:Saccharomyces cerevisiae (MIC<50¦ÌM)	[Ref.30658410] 10.4% hemolysis at 50 ¦ÌM against rat blood cells	Linear	Free	Free	None	L	[Ref.30658410] No cytotoxicity information found.	Not found	30658410	Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi:?10.3390/toxins11010050	"Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki"	Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components
DRAMP21456	KIKWGKIFKKGGKLIGKTALEAAANAAASEAISAMASQNE	40	"PLP3 (Insects, animals)"	A0A348G5V9	Belongs to the formicidae venom precursor-01 superfamily.	Not found	Odontomachus monticola (Trap-jaw ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	¦Á-helix predicted by Proteus	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria. Antifungal activity against Saccharomyces cerevisiae.	[Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC<25¦ÌM);##Gram-negative bacteria:Escherichia coli (MIC<3.1¦ÌM);##Fungi:Saccharomyces cerevisiae (MIC<50¦ÌM)	[Ref.30658410] 0% hemolysis at 50 ¦ÌM against rat blood cells	Linear	Free	Free	None	L	[Ref.30658410] No cytotoxicity information found.	Not found	30658410	Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi:?10.3390/toxins11010050	"Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki"	Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components
DRAMP21457	GVKELFGKAWGLVKKHLPKACGLLGYVKQ	29	"PLP4 (Insects, animals)"	A0A348G5W0	Belongs to the formicidae venom precursor-01 superfamily.	Not found	Odontomachus monticola (Trap-jaw ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	¦Á-helix predicted by Proteus	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria. Antifungal activity against Saccharomyces cerevisiae.	[Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC<3.1¦ÌM);##Gram-negative bacteria:Escherichia coli (MIC<3.1¦ÌM);##Fungi:Saccharomyces cerevisiae (MIC<3.1¦ÌM)	[Ref.30658410] 10.5% hemolysis at 50 ¦ÌM against rat blood cells	Cyclic	Free	Free	Cys21 is S-(carbamoylmethyl)-L-cysteine and there is a interchain disulfide bond between two PLP4 peptide molecules.	L	[Ref.30658410] No cytotoxicity information found.	Not found	30658410	Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi:?10.3390/toxins11010050	"Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki"	Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components
DRAMP21458	IWGALLGTLIPAITSAIQ	18	"PLP5 (Insects, animals)"	A0A348G5W1	Belongs to the formicidae venom precursor-01 superfamily.	Not found	Odontomachus monticola (Trap-jaw ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	¦Á-helix predicted by Proteus	Not found	None	Function: Antibacterial activity against Gram-nagetive bacteria. 	[Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC Negative);##Gram-negative bacteria:Escherichia coli (MIC<50¦ÌM);##Fungi:Saccharomyces cerevisiae (MIC Negative)	[Ref.30658410] 6.9% hemolysis at 10¦ÌM and 94.8% at 50 ¦ÌM against rat blood cells	Linear	Free	Amidation	None	L	[Ref.30658410] No cytotoxicity information found.	Not found	30658410	Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi:?10.3390/toxins11010050	"Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki"	Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components
DRAMP21459	IKGKKIMKNMGKAMKIAGKVAKAMAPIVVPLIVSAA	36	"PLP6 (Insects, animals)"	A0A348G5W2	Belongs to the formicidae venom precursor-01 superfamily.	Not found	Odontomachus monticola (Trap-jaw ant)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	¦Á-helix predicted by Proteus	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	[Ref.30658410] Gram-positive bacteria:Staphylococcus aureus (MIC<3.1¦ÌM);##Gram-negative bacteria:Escherichia coli (MIC<3.1¦ÌM);##Fungi:Saccharomyces cerevisiae (MIC Negative)	[Ref.30658410] 0% hemolysis at 50 ¦ÌM against rat blood cells	Linear	Free	Amidation	None	L	[Ref.30658410] No cytotoxicity information found.	Not found	30658410	Toxins (Basel). 2019 Jan; 11(1): 50. Published online 2019 Jan 17. doi:?10.3390/toxins11010050	"Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki"	Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components
DRAMP21460	IHKFWRCRRRFCRWFKHI	18	PQ (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix predicted by I-Tasser	"In PBS, the ¦Á-helix content of PQ is 26.91% and the ¦Â-strand content of that is 11.16%. In SDS, the ¦Á-helix content of PQ is 32.02% and the ¦Â-strand of that is 6.15%. In TFE, the ¦Á-helix content of PQ is 36.82% and the ¦Â-strand of that is 4.28%."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30538681] Gram-positive bacteria:Staphylococcus aureus ATCC 29213(MIC=8¦ÌM), Staphylococcus aureus ATCC 43300(MIC=8¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=8¦ÌM), Streptococci faecalis ATCC 29212(MIC=16¦ÌM), Bacillus subtilis CMCC 63501(MIC=16¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=16¦ÌM), Escherichia coli UB 1005(MIC=8¦ÌM), bacteria pyocyaneum ATCC 27853(MIC=8¦ÌM), Salmonella typhimurium ATCC 7731(MIC=8¦ÌM), Salmonella Pulloru C79-13(MIC=8¦ÌM)"	[Ref.30538681] MHC>128¦ÌM against human blood cells.The minimum hemolytic concentration (MHC) is defined as the peptide concentration resulting in 5% hemolysis.	Linear	Free	Amidation	None	L	"[Ref.30538681] The cell viability of intestinal epithelial cells (IPEC-J2) induced by PQ is 68.2%, 68.6%, 66.8%,63.6%, 69.1%, 62.2%, 55.8% and 28.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	30538681	Front Microbiol. 2018; 9: 2832. Published online 2018 Nov 27. doi:?10.3389/fmicb.2018.02832	"Na Dong,?Shuli Chou,?Jiawei Li,?Chenyu Xue,?Xinran Li,?Baojing Cheng,?Anshan Shan,?and?Li Xu"	Short Symmetric-End Antimicrobial Peptides Centered on ¦Â-Turn Amino Acids Unit Improve Selectivity and Stability
DRAMP21461	IHKFWRPGRWFKHI	14	PP (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	A combination of ¦Á-helical and ¦Â-hairpin	"In PBS, the ¦Á-helix content of PQ is 12.35% and the ¦Â-strand content of that is 16.30%. In SDS, the ¦Á-helix content of PQ is 9.86% and the ¦Â-strand of that is 11.56%. In TFE, the ¦Á-helix content of PQ is 37.54% and the ¦Â-strand of that is 2.54%."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30538681] Gram-positive bacteria:Staphylococcus aureus ATCC 29213(MIC=16¦ÌM), Staphylococcus aureus ATCC 43300(MIC=16¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=16¦ÌM), Streptococci faecalis ATCC 29212(MIC=8¦ÌM), Bacillus subtilis CMCC 63501(MIC=8¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8¦ÌM), Escherichia coli UB 1005(MIC=4¦ÌM), bacteria pyocyaneum ATCC 27853(MIC=4¦ÌM), Salmonella typhimurium ATCC 7731(MIC=8¦ÌM), Salmonella Pulloru C79-13(MIC=4¦ÌM)"	[Ref.30538681] MHC>128¦ÌM against human blood cells.The minimum hemolytic concentration (MHC) is defined as the peptide concentration resulting in 5% hemolysis.	Linear	Free	Amidation	None	L	"[Ref.30538681] The cell viability of intestinal epithelial cells (IPEC-J2) induced by PP is 67.7%, 69.1%, 70.5%, 65.4%, 61.3%, 65.0%, 70.5% and 68.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	30538681	Front Microbiol. 2018; 9: 2832. Published online 2018 Nov 27. doi:?10.3389/fmicb.2018.02832	"Na Dong,?Shuli Chou,?Jiawei Li,?Chenyu Xue,?Xinran Li,?Baojing Cheng,?Anshan Shan,?and?Li Xu"	Short Symmetric-End Antimicrobial Peptides Centered on ¦Â-Turn Amino Acids Unit Improve Selectivity and Stability
DRAMP21462	IHKFWRGGRWFKHI	14	GG (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	A combination of ¦Á-helical and ¦Â-hairpin	"In PBS, the ¦Á-helix content of PQ is 1.49% and the ¦Â-strand content of that is 32.19%. In SDS, the ¦Á-helix content of PQ is 11.99% and the ¦Â-strand of that is 9.42%. In TFE, the ¦Á-helix content of PQ is 18.98% and the ¦Â-strand of that is 11.53%."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30538681] Gram-positive bacteria:Staphylococcus aureus ATCC 29213(MIC=16¦ÌM), Staphylococcus aureus ATCC 43300(MIC=32¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=32¦ÌM), Streptococci faecalis ATCC 29212(MIC=32¦ÌM), Bacillus subtilis CMCC 63501(MIC=16¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8¦ÌM), Escherichia coli UB 1005(MIC=8¦ÌM), bacteria pyocyaneum ATCC 27853(MIC=16¦ÌM), Salmonella typhimurium ATCC 7731(MIC=64¦ÌM), Salmonella Pulloru C79-13(MIC=8¦ÌM)"	[Ref.30538681] MHC>128¦ÌM against human blood cells.The minimum hemolytic concentration (MHC) is defined as the peptide concentration resulting in 5% hemolysis.	Linear	Free	Amidation	None	L	"[Ref.30538681] The cell viability of intestinal epithelial cells (IPEC-J2) induced by GG is 67.7%, 74.2%, 76.5%, 72.4%, 72.8%, 69.1%, 65.9% and 59.9% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	30538681	Front Microbiol. 2018; 9: 2832. Published online 2018 Nov 27. doi:?10.3389/fmicb.2018.02832	"Na Dong,?Shuli Chou,?Jiawei Li,?Chenyu Xue,?Xinran Li,?Baojing Cheng,?Anshan Shan,?and?Li Xu"	Short Symmetric-End Antimicrobial Peptides Centered on ¦Â-Turn Amino Acids Unit Improve Selectivity and Stability
DRAMP21463	IHKFWRRWFKHI	12	Qa (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix predicted by I-Tasser	"In PBS, the ¦Á-helix content of PQ is 2.89% and the ¦Â-strand content of that is 19.89%. In SDS, the ¦Á-helix content of PQ is 5.54% and the ¦Â-strand of that is 14.12%. In TFE, the ¦Á-helix content of PQ is 3.08% and the ¦Â-strand of that is 18.1%."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30538681] Gram-positive bacteria:Staphylococcus aureus ATCC 29213(MIC=8¦ÌM), Staphylococcus aureus ATCC 43300(MIC=16¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=16¦ÌM), Streptococci faecalis ATCC 29212(MIC=16¦ÌM), Bacillus subtilis CMCC 63501(MIC=32¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=16¦ÌM), Escherichia coli UB 1005(MIC=8¦ÌM), bacteria pyocyaneum ATCC 27853(MIC=16¦ÌM), Salmonella typhimurium ATCC 7731(MIC=16¦ÌM), Salmonella Pulloru C79-13(MIC=16¦ÌM)"	[Ref.30538681] MHC>128¦ÌM against human blood cells.The minimum hemolytic concentration (MHC) is defined as the peptide concentration resulting in 5% hemolysis.	Linear	Free	Amidation	None	L	"[Ref.30538681] The cell viability of intestinal epithelial cells (IPEC-J2) induced by Qa is 61.3%, 66.8%, 76.5%, 71.4%, 72.4%, 73.3%, 65.9% and 39.6% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	30538681	Front Microbiol. 2018; 9: 2832. Published online 2018 Nov 27. doi:?10.3389/fmicb.2018.02832	"Na Dong,?Shuli Chou,?Jiawei Li,?Chenyu Xue,?Xinran Li,?Baojing Cheng,?Anshan Shan,?and?Li Xu"	Short Symmetric-End Antimicrobial Peptides Centered on ¦Â-Turn Amino Acids Unit Improve Selectivity and Stability
DRAMP21464	IHFKWRRWKFHI	12	Qna (De Novo Synthesis)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Linear and unordered conformation	"In PBS, the ¦Á-helix content of PQ is 3.46% and the ¦Â-strand content of that is 17.46%. In SDS, the ¦Á-helix content of PQ is 1.29% and the ¦Â-strand of that is 21.49%. In TFE, the ¦Á-helix content of PQ is 0.73% and the ¦Â-strand of that is 18.82%."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	"[Ref.30538681] Gram-positive bacteria:Staphylococcus aureus ATCC 29213(MIC=32¦ÌM), Staphylococcus aureus ATCC 43300(MIC=32¦ÌM), Staphylococcus epidermidis ATCC 12228(MIC=32¦ÌM), Streptococci faecalis ATCC 29212(MIC=64¦ÌM), Bacillus subtilis CMCC 63501(MIC=64¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=32¦ÌM), Escherichia coli UB 1005(MIC=16¦ÌM), bacteria pyocyaneum ATCC 27853(MIC=32¦ÌM), Salmonella typhimurium ATCC 7731(MIC=32¦ÌM), Salmonella Pulloru C79-13(MIC=32¦ÌM)"	[Ref.30538681] MHC>128¦ÌM against human blood cells.The minimum hemolytic concentration (MHC) is defined as the peptide concentration resulting in 5% hemolysis.	Linear	Free	Amidation	None	L	"[Ref.30538681] The cell viability of intestinal epithelial cells (IPEC-J2) induced by Qna is 67.3%, 65.0%, 73.7%, 77.9%, 68.2%, 68.2%, 62.2% and 51.2% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM."	Not found	30538681	Front Microbiol. 2018; 9: 2832. Published online 2018 Nov 27. doi:?10.3389/fmicb.2018.02832	"Na Dong,?Shuli Chou,?Jiawei Li,?Chenyu Xue,?Xinran Li,?Baojing Cheng,?Anshan Shan,?and?Li Xu"	Short Symmetric-End Antimicrobial Peptides Centered on ¦Â-Turn Amino Acids Unit Improve Selectivity and Stability
DRAMP21465	DEMKLDGFNMHLE	13	P1-Ll-1577 (De Novo Synthesis)	No entry found	Not found	Not found	?Leptodactylus latrans?(Anura: Leptodactylidae)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil predicted by PSIPRED and GOR V	"P1-Ll-1577, although presenting contributions of turn structure, is less ordered in the presence of TFE (percentage of an unordered structure higher than 40%)."	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	[Ref.30423858] Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=40.5¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=20¦ÌM)	[Ref.30423858] 100% hemolysis MHC=640¦ÌM against human blood cells	Linear	Free	Amidation	None	L	[Ref.30423858] No cytotoxicity information found.	Not found	30423858	Molecules. 2018 Nov; 23(11): 2943. Published online 2018 Nov 11. doi:?10.3390/molecules23112943	"Alvaro Siano, Maria Veronica Humpola, Eliandre de Oliveira, Fernando Albericio, Arturo C Simonetta, Rafael Lajmanovich, Georgina G Tonarelli"	Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides
DRAMP21466	AAGKGLVSNLLEK	13	P2-Ll-1298 (De Novo Synthesis)	No entry found	Not found	Not found	?Leptodactylus latrans?(Anura: Leptodactylidae)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Helix(K4-E12) predicted by PSIPRED and helix(L6-L10) predicted by GOR V	P2-Ll-1298 showed contributions of ¦Á-helix.	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	[Ref.30423858] Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=49¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=24.6¦ÌM)	[Ref.30423858] 100% hemolysis MHC=320¦ÌM against human blood cells	Linear	Free	Amidation	None	L	[Ref.30423858] No cytotoxicity information found.	Not found	30423858	Molecules. 2018 Nov; 23(11): 2943. Published online 2018 Nov 11. doi:?10.3390/molecules23112943	"Alvaro Siano, Maria Veronica Humpola, Eliandre de Oliveira, Fernando Albericio, Arturo C Simonetta, Rafael Lajmanovich, Georgina G Tonarelli"	Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides
DRAMP21467	GLLDFLKAAGKGLVSNLLEK	20	P3-Ll-2085 (De Novo Synthesis)	No entry found	Not found	Not found	?Leptodactylus latrans?(Anura: Leptodactylidae)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"Helix(L2-E19) predicted by PSIPRED and Helix(L3-A9, L13-L17) predicted by GOR V"	Deconvolution spectra by SELCON and CONTILL method indicated more than 70% helical structure for P3-Ll-2085	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.	[Ref.30423858] Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=15¦ÌM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=15¦ÌM)	[Ref.30423858] 100% hemolysis MHC=40¦ÌM against human blood cells	Linear	Free	Amidation	None	L	[Ref.30423858] No cytotoxicity information found.	Not found	30423858	Molecules. 2018 Nov; 23(11): 2943. Published online 2018 Nov 11. doi:?10.3390/molecules23112943	"Alvaro Siano, Maria Veronica Humpola, Eliandre de Oliveira, Fernando Albericio, Arturo C Simonetta, Rafael Lajmanovich, Georgina G Tonarelli"	Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides
DRAMP21310	RRLRKKTRKRLK	12	RK12 (Derived from PMAP-36)	No entry found	Not found	Not found	synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	No ¦Á-helix content in 50%TFE	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC>128 ¦ÌM), Staphylococcus aureus 25923 (MIC>128 ¦ÌM), Staphylococcus  epidermidis 12228 (MIC>128 ¦ÌM);##Gram-negative bacteria: Escherichia coli 25922 (MIC>128 ¦ÌM), Escherichia coli 1005 (MIC=64 ¦ÌM), Staphylococcus typhi (MIC>128 ¦ÌM)"	[Ref.31276398] MHC>128¦ÌM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs).	Linear	Free	Amidation	None	L	"[Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RK12 is 91.7%, 96.2%, 95.2%, 95.3%, 96.2%, 94.7%, 98.8% and 99.3% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 ¦ÌM"	Not found	31276398	J Med Chem. 2019 Aug 8;62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00288.	"Lyu Y,?Chen T,?Shang L,?Yang Y,?Li Z,?Zhu J,?Shan A."	Design of Trp-rich dodecapeptides with broad-spectrum antimicrobial potency and membrane-disruptive mechanism
DRAMP21481	KKKKKKAAFAAWAAFAA	17	6K-F17	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¢ÙRandom coils in aqueous buffer. ¢Ú¦Á-helix in SDS detergent micelles.	"As previously reported, 6K-F17 adopts a random coil structure in aqueous buffer and an ¦Á helix in the presence of SDS detergent micelles."	None	Function: Antibacterial activity against Gram-negative bacteria. No experiments about antibacterial activity against Gram-positive bacteria are recorded.	[Ref.29275987] Gram-negative bacteria: E. coli (MIC= 1.6 ¦ÌM)	[Ref.29275987] MHC = 320 ¦ÌM against human red blood cells. Note: Minimum hemolytic concentration (MHC) is the minimum peptide concentration at which red blood cells undergo > 2% hemolysis.	Linear 	Free	Amidation	None	L	No cytotoxicity information found in the reference	Not found	29275987	Bioorg Med Chem. 2018 Mar 15;26(6):1189-1196. doi: 10.1016/j.bmc.2017.10.020. Epub 2017 Oct 21.	"Tracy A Stone, Gregory B Cole, Huong Q Nguyen, Simon Sharpe, Charles M Deber"	Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides
DRAMP21494	GFLSILKKVLPKVJAHJK	18	MEP-N	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	¢Ù12% ¦Á-helical content in water.¢Ú43% ¦Á-helical content in 50% TFE. ¢Û48% ¦Á-helical content in 8mM SDS.	No other descriptive information about the structure found in the literature	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria and Antifungal activity against Candida albicans.	"[Ref.22526241] Gram-positive bacteria: Micrococcus luteus (MIC = 1 ¦ÌM), Bacillus subtilis (MIC = 0.5 ¦ÌM), Staphylococcus aureus (MIC = 2.5 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 0.9 ¦ÌM), Pseudomonas aeruginosa (MIC = 17.3 ¦ÌM);##Fungi: Candida albicans (MIC = 15 ¦ÌM)."	[Ref.22526241] LC50 = 50 ¦ÌM. Note: LC50 is the concentration of a peptide able to lyse 50% of human erthrocytes in the assay.	Linear 	Free	Amidation	The J (position: 14 and 17) in sequence are norleucine. 	L	No cytotoxicity information found in the reference	Not found	22526241	Amino Acids. 2012 Nov;43(5):2047-58. doi: 10.1007/s00726-012-1283-1. Epub 2012 Apr 27.	"Hubert Chapuis, Ji?ina Slaninov¨¢, Lucie Bedn¨¢rov¨¢, Lenka Monincov¨¢, Milo? Bud¨§?¨ªnsk?, V¨¢clav ?e?ovsk?"	Effect of hydrocarbon stapling on the properties of ¦Á-helical antimicrobial peptides isolated from the venom of hymenoptera
DRAMP21579	WWVXARAXRR	10	Val-nHSLP	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	0.7% ¦Á-helix and 33.4% ¦Â-strand in 20 mM potassium phosphate buffer; 0.8% ¦Á-helix and 35.8% ¦Â-strand in 20 mM potassium phosphate buffer made 30% in T	"Overall, the peptides showed some ¦Â-strand secondary structural characteristics and little ¦Á-helical content."	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Antifungal activity against Candida albicans is not noteable under 20 ¦ÌM.	"[Ref.28073163] Gram-positive bacteria: Bacillus megaterium ATCC 14581 (IC50 = 2.25 ¦ÌM, MIC = 5.00 ¦ÌM), Staphylococcus aureus ATCC 6538 (IC50 = 0.63 ¦ÌM, MIC = 10.0 ¦ÌM), Enterococcus faecalis ATCC 29212 (IC50 = 0.66 ¦ÌM, MIC = 5.00 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 700926 (IC50 = 38.3 ¦ÌM, MIC > 20 ¦ÌM);## Fungi: Candida albicans 002 ATCC 64385 (IC50 > 20 ¦ÌM, MIC > 20 ¦ÌM), C. albicans 004 ATCC MYA-2876 (IC50 > 20 ¦ÌM, MIC > 20 ¦ÌM)."	[Ref.28073163] HC50 = 13.4 ¦ÌM against human red blood cells. Note:  HC50 is the half-maximal hemolytic concentration.	Linear 	Acylation (Valerylamide)	Amidation	¢ÙThe X (position: 4 and 8) in sequence are (S)-2-(4'-pentenyl)-alanine. ¢ÚX (4) and X (8) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple.	L	No cytotoxicity information found in the reference	Not found	28073163	Biopolymers. 2017 May;108(3). doi: 10.1002/bip.23006.	"Zachary B Jenner, Christopher M Crittenden, Mart¨ªn Gonzalez, Jennifer S Brodbelt, Kerry A Bruns"	Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity
DRAMP21604	KXWKAXK	7	U1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix in 25 mM potassium phosphate buffer solution (pH 6.5)	"As expected, in the far ultraviolet circular dichroism (CD) experiment, the stapled heptapeptides displayed enhanced helical contents compared to their corresponding unstapled counterparts."	None	Function: Antibacterial activity against Gram-negative bacteria. Antibacterial activity against Gram-positive bacteria is not noteable under 100 ¦ÌM.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC > 100 ¦ÌM), Staphylococcus aureus ATCC 6538p (MIC > 100 ¦ÌM), Staphylococcus epidermis ATCC 12228 (MIC > 100 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC = 100 ¦ÌM), Shigella dysentariae ATCC 9752 (MIC > 100 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC > 100 ¦ÌM), Klebsiella pneumonia ATCC 10031 (MIC > 100 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC > 100 ¦ÌM)."	"0.91%, 0.76%, 0.70%, 0.91%, 0.88%, 0.90%, 0.75% and 0.99% hemolysis against human red blood cells at 0.8, 1.6, 3.1, 6.3, 12.5, 25.0, 50.0 and 100.0 ¦ÌM."	Linear	Acetylation	Amidation	"¢ÙThe X (position: 2 and 6) in sequence are (S)-¦Á-methyl, ¦Á-pentenylglycine. Note: the Experimental section presenst that X is (S)-¦Á-methyl, ¦Á-pentenylglycine, while the Results section presents that X is pentenylalanine. We incline to the former representation according to previous papers published by the research group which the author belonged. "	L	No cytotoxicity information found.	Not found	Not found	B KOREAN CHEM SOC	"Thuy T.T. Dinh, Do-Hee Kim, Song-Jin Lee, Young-Woo Kim"	De Novo Design and Their Antimicrobial Activity of Stapled Amphipathic Helices of Heptapeptides
DRAMP21606	KXAKWXK	7	U2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	¦Á-helix in 25 mM potassium phosphate buffer solution (pH 6.5)	"As expected, in the far ultraviolet circular dichroism (CD) experiment, the stapled heptapeptides displayed enhanced helical contents compared to their corresponding unstapled counterparts."	None	Function: Antibacterial activity against Gram-negative bacteria. Antibacterial activity against Gram-positive bacteria is not noteable under 100 ¦ÌM.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC > 100 ¦ÌM), Staphylococcus aureus ATCC 6538p (MIC > 100 ¦ÌM), Staphylococcus epidermis ATCC 12228 (MIC > 100 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC > 100 ¦ÌM), Shigella dysentariae ATCC 9752 (MIC > 100 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC > 100 ¦ÌM), Klebsiella pneumonia ATCC 10031 (MIC = 100 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC > 100 ¦ÌM)."	"0.76%, 0.86%, 0.84%, 1.05%, 0.97%, 0.93%, 0.96% and 0.88% hemolysis against human red blood cells at 0.8, 1.6, 3.1, 6.3, 12.5, 25.0, 50.0 and 100.0 ¦ÌM."	Linear	Acetylation	Amidation	"¢ÙThe X (position: 2 and 6) in sequence are (S)-¦Á-methyl, ¦Á-pentenylglycine. Note: the Experimental section presenst that X is (S)-¦Á-methyl, ¦Á-pentenylglycine, while the Results section presents that X is pentenylalanine. We incline to the former representation according to previous papers published by the research group which the author belonged. "	L	No cytotoxicity information found.	Not found	Not found	B KOREAN CHEM SOC	"Thuy T.T. Dinh, Do-Hee Kim, Song-Jin Lee, Young-Woo Kim"	De Novo Design and Their Antimicrobial Activity of Stapled Amphipathic Helices of Heptapeptides
DRAMP21608	KXWKLXK	7	U3	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 25 mM potassium phosphate buffer solution (pH 6.5)	"As expected, in the far ultraviolet circular dichroism (CD) experiment, the stapled heptapeptides displayed enhanced helical contents compared to their corresponding unstapled counterparts."	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC = 25 ¦ÌM), Staphylococcus aureus ATCC 6538p (MIC = 25 ¦ÌM), Staphylococcus epidermis ATCC 12228 (MIC = 100 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC = 25 ¦ÌM), Shigella dysentariae ATCC 9752 (MIC = 100 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC > 100 ¦ÌM), Klebsiella pneumonia ATCC 10031 (MIC = 50 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC = 100 ¦ÌM)."	"0.88%, 0.72%, 0.90%, 1.25%, 0.75%, 0.98%, 1.03% and 1.12% hemolysis against human red blood cells at 0.8, 1.6, 3.1, 6.3, 12.5, 25.0, 50.0 and 100.0 ¦ÌM."	Linear	Acetylation	Amidation	"¢ÙThe X (position: 2 and 6) in sequence are (S)-¦Á-methyl, ¦Á-pentenylglycine. Note: the Experimental section presenst that X is (S)-¦Á-methyl, ¦Á-pentenylglycine, while the Results section presents that X is pentenylalanine. We incline to the former representation according to previous papers published by the research group which the author belonged. "	L	No cytotoxicity information found.	Not found	Not found	B KOREAN CHEM SOC	"Thuy T.T. Dinh, Do-Hee Kim, Song-Jin Lee, Young-Woo Kim"	De Novo Design and Their Antimicrobial Activity of Stapled Amphipathic Helices of Heptapeptides
DRAMP21610	KXLKWXK	7	U4	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 25 mM potassium phosphate buffer solution (pH 6.5)	"As expected, in the far ultraviolet circular dichroism (CD) experiment, the stapled heptapeptides displayed enhanced helical contents compared to their corresponding unstapled counterparts."	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC = 25 ¦ÌM), Staphylococcus aureus ATCC 6538p (MIC = 25 ¦ÌM), Staphylococcus epidermis ATCC 12228 (MIC = 100 ¦ÌM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC = 25 ¦ÌM), Shigella dysentariae ATCC 9752 (MIC > 100 ¦ÌM), Salmonella typhimurium ATCC 14028 (MIC > 100 ¦ÌM), Klebsiella pneumonia ATCC 10031 (MIC = 50 ¦ÌM), Pseudomonas aeruginosa ATCC 27853 (MIC = 100 ¦ÌM)."	"0.80%, 1.98%, 1.28%, 0.81%, 0.97%, 1.19%, 1.19% and 1.22% hemolysis against human red blood cells at 0.8, 1.6, 3.1, 6.3, 12.5, 25.0, 50.0 and 100.0 ¦ÌM."	Linear	Acetylation	Amidation	"¢ÙThe X (position: 2 and 6) in sequence are (S)-¦Á-methyl, ¦Á-pentenylglycine. Note: the Experimental section presenst that X is (S)-¦Á-methyl, ¦Á-pentenylglycine, while the Results section presents that X is pentenylalanine. We incline to the former representation according to previous papers published by the research group which the author belonged. "	L	No cytotoxicity information found.	Not found	Not found	B KOREAN CHEM SOC	"Thuy T.T. Dinh, Do-Hee Kim, Song-Jin Lee, Young-Woo Kim"	De Novo Design and Their Antimicrobial Activity of Stapled Amphipathic Helices of Heptapeptides
DRAMP21616	qqrkrkiwsilaplgttlvklvagig	26	DRIM	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¢ÙDisordered conformation in aqueous solutions [pure water (H?O), phosphate buffer (PB, 10 mM), and phosphate buffer with high salt (NaF, 100 mM)]. ¢Ú50"	"Our CD data show that all four linear peptides were generally disordered in aqueous solution, as expected, but prominent effects were seen regarding the impact of the staple."	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.28921993] Gram-positive bacteria: Staphylococcus aureus (MIC = 32 ¦Ìg/mL), Enterococcus faecalis (MIC = 32 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli (MIC = 32 ¦Ìg/mL), Pseudomonas aeruginosa (MIC = 64 ¦Ìg/mL)"	"[Ref.28921993] 60.5%, 98.0%, 95.1%, 99.0%, 97.9%, 96.3%, 98.8% and 98.2% hemolysis against human red blood cells at 5, 7.5, 10, 15, 20, 25, 30 and 40 ¦Ìg/ml."	Linear	Free	Amidation	None	D	[Ref.28921993] The toxicity of DRIM toward HEK293 and HeLa cells is much less than nonaarginine (R9) by use of flow cytometry and the peptide doesn't show any cytotoxicity at 2 ¦ÌM.	Not found	28921993	J Med Chem. 2017 Oct 12;60(19):8071-8082. doi: 10.1021/acs.jmedchem.7b00813. Epub 2017 Sep 26.	"Marco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen B¨¹rck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich"	Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties.
DRAMP21618	PLILLRLLRGQF	12	WWSP	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¢ÙDisordered conformation in aqueous solutions [pure water (H?O), phosphate buffer (PB, 10 mM), and phosphate buffer with high salt (NaF, 100 mM)]. ¢ÚMi"	"Our CD data show that all four linear peptides were generally disordered in aqueous solution, as expected, but prominent effects were seen regarding the impact of the staple."	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.28921993] Gram-positive bacteria: Staphylococcus aureus (MIC = 16 ¦Ìg/mL), Enterococcus faecalis (MIC = 64 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli (MIC = 256 ¦Ìg/mL), Pseudomonas aeruginosa (MIC > 256 ¦Ìg/mL)"	"[Ref.28921993] 3.9%, 2.6%, 3.6%, 4.3%, 4.0%, 4.6%, 3.3% and 2.9% hemolysis against human red blood cells at 5, 7.5, 10, 15, 20, 25, 30 and 40 ¦Ìg/ml."	Linear	Free	Amidation	None	L	[Ref.28921993] The toxicity of WWSP toward HEK293 and HeLa cells is much less than nonaarginine (R9) by use of flow cytometry and the peptide doesn't show any cytotoxicity at 2 ¦ÌM.	Not found	28921993	J Med Chem. 2017 Oct 12;60(19):8071-8082. doi: 10.1021/acs.jmedchem.7b00813. Epub 2017 Sep 26.	"Marco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen B¨¹rck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich"	Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties.
DRAMP21620	AAVLLPVLLAAP	12	KFGF	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¢ÙDisordered conformation in aqueous solutions [pure water (H?O), phosphate buffer (PB, 10 mM), and phosphate buffer with high salt (NaF, 100 mM)]. ¢Ú31"	"Our CD data show that all four linear peptides were generally disordered in aqueous solution, as expected, but prominent effects were seen regarding the impact of the staple."	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.28921993] Gram-positive bacteria: Staphylococcus aureus (MIC > 256 ¦Ìg/mL), Enterococcus faecalis (MIC > 256 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli (MIC > 256 ¦Ìg/mL), Pseudomonas aeruginosa (MIC > 256 ¦Ìg/mL)"	"[Ref.28921993] 0.4%, 0.2%, 0.3%, 0.2%, 1.5%, 0.2% and 0.1% hemolysis against human red blood cells at 7.5, 10, 15, 20, 25, 30 and 40 ¦Ìg/ml."	Linear	Free	Amidation	None	L	[Ref.28921993] The toxicity of KFGF toward HEK293 and HeLa cells is much less than nonaarginine (R9) by use of flow cytometry and the peptide doesn't show any cytotoxicity at 2 ¦ÌM.	Not found	28921993	J Med Chem. 2017 Oct 12;60(19):8071-8082. doi: 10.1021/acs.jmedchem.7b00813. Epub 2017 Sep 26.	"Marco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen B¨¹rck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich"	Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties.
DRAMP21622	KLALKALKALKAALKLA	17	MAP-1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¢ÙDisordered conformation in aqueous solutions [pure water (H?O), phosphate buffer (PB, 10 mM), and phosphate buffer with high salt (NaF, 100 mM)]. ¢ÚTy"	"Our CD data show that all four linear peptides were generally disordered in aqueous solution, as expected, but prominent effects were seen regarding the impact of the staple."	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.28921993] Gram-positive bacteria: Staphylococcus aureus (MIC = 16 ¦Ìg/mL), Enterococcus faecalis (MIC = 256 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli (MIC = 16 ¦Ìg/mL), Pseudomonas aeruginosa (MIC = 256 ¦Ìg/mL)"	"[Ref.28921993] 1.6%, 0.8%, 0.6%, 0.4%, 0.7%, 1.8%, 0.4% and 0.1% hemolysis against human red blood cells at 5, 7.5, 10, 15, 20, 25, 30 and 40 ¦Ìg/ml."	Linear	Free	Amidation	None	L	[Ref.28921993] The toxicity of MAP-1 toward HEK293 and HeLa cells is much less than nonaarginine (R9) by use of flow cytometry and the peptide doesn't show any cytotoxicity at 2 ¦ÌM.	Not found	28921993	J Med Chem. 2017 Oct 12;60(19):8071-8082. doi: 10.1021/acs.jmedchem.7b00813. Epub 2017 Sep 26.	"Marco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen B¨¹rck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich"	Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties.
DRAMP21627	TLKQFAKGVGKWLVK	15	E2EM15W	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Random coil coformation with 4% helical content in a 25 mM potassium phosphate buffer solution at 20 ¡æ.	"Circular dichroism also revealed that E2EM15W is even less structured under the same conditions, displaying a helical content of 4%; it is well established that the shorter a peptide is, the more difficult it is to form an ¦Á-helical conformation."	None	Function: Antibacterial activity against Gram-positive bacteria. Antibacterial activity against Gram-negative bacteria is not noteable under 200 ¦Ìg/mL.	"[Ref.24211019] Gram-positive bacteria: Bacillus subtilis (MIC = 200 ¦Ìg/mL), Staphylococcus aureus (MIC = 100 ¦Ìg/mL), Staphylococcus epidermis (MIC > 200 ¦Ìg/mL);##Gram-negative bacteria: Escherichia coli (MIC = 200 ¦Ìg/mL), Shigella dysentariae (MIC > 200 ¦Ìg/mL), Salmonella typhimurium (MIC > 200 ¦Ìg/mL), Klebsiella pneumonia (MIC > 200 ¦Ìg/mL), Proteus mirabilis (MIC > 200 ¦Ìg/mL), Pseudomonas aeuginose (MIC > 200 ¦Ìg/mL)."	[Ref.24211019] No hemolytic activity information found.	Linear	Acetylation	Amidation	None	L	No cytotoxicity information found in the reference	Not found	24211019	Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. doi: 10.1016/j.bmcl.2013.10.031. Epub 2013 Oct 26.	"Thanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim"	Truncated and constrained helical analogs of antimicrobial esculentin-2EM
DRAMP21631	RLVRILVSKRPVAIKPYFRL	20	SLAY-P1	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 2 ¦ÌM), Acinetobacter baumannii 5075 (MBC ¡Ü 2 ¦ÌM), Pseudomonas aeruginosa 14 (MBC ¡Ü 2 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC ¡Ü 2 ¦ÌM)."	[Ref.29307492] The peptide showed 4.0% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21632	TTSIRRRYQVSLIRRHRGKR	20	SLAY-P2	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 16 ¦ÌM), Acinetobacter baumannii 5075 (MBC ¡Ü 2 ¦ÌM), Pseudomonas aeruginosa 14 (MBC ¡Ü 2 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 4 ¦ÌM)."	[Ref.29307492] The peptide showed 3.1% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21633	TCRTNRPCFYDLDLNVCRCS	20	SLAY-P3 cyclic	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC ¡Ü 2 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 4 ¦ÌM), Pseudomonas aeruginosa 14 (MBC ¡Ü 2 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 4 ¦ÌM)."	[Ref.29307492] The peptide showed 0.9% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Cyclic	Free	Free	"Disulfide bonds between Cys2 and Cys19, Cys8 and Cys17."	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21634	SNGDGTLDAGSTCAPFYARA	20	SLAY-P4	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 2 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 16 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 4 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 4 ¦ÌM)."	[Ref.29307492] The peptide showed 1.8% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21635	YYNPLPHDCGRDNNTDICSR	20	SLAY-P5 cyclic	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 4 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 8 ¦ÌM), Pseudomonas aeruginosa 14 (MBC ¡Ü 2 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC ¡Ü 2 ¦ÌM)."	[Ref.29307492] The peptide showed 1.1% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Cyclic	Free	Free	Disulfide bonds between Cys9 and Cys18	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21636	LSVDKRPVLHPEHIYGHNHY	20	SLAY-P6	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 4 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 32 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 8 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC ¡Ü 128 ¦ÌM)."	[Ref.29307492] The peptide showed 3.1% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21637	IHRDQQHESFLDARPEPGLTE	21	SLAY-P7	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 4 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 16 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 4 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 4 ¦ÌM)."	[Ref.29307492] The peptide showed 0.7% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21638	TIDFGVRNINQSNLVYDTER	20	SLAY-P8	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 8 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 16 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 8 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC  > 128 ¦ÌM)."	[Ref.29307492] The peptide showed 10.8% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21639	PCNPDHDYRPFGNFRIAFTT	20	SLAY-P9	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 8 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 16 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 8 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 8 ¦ÌM)."	[Ref.29307492] The peptide showed 0% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21640	TRDTNDLISSRTAAPSMV	18	SLAY-P10	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 16 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 64 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 8 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 32 ¦ÌM)."	[Ref.29307492] The peptide showed 8.4% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21641	LPLPSCSSHGGDADNTSQRN	20	SLAY-P11	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 16 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 16 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 32 ¦ÌM)."	[Ref.29307492] The peptide showed 2.6% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21642	PNDPDSPCVYRMPNARGCSI	20	SLAY-P12	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 16 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 16 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 16 ¦ÌM)."	[Ref.29307492] The peptide showed 0.9% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21643	YDLSDSNCLPANRDKRYYVI	20	SLAY-P13	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 16 ¦ÌM), Acinetobacter baumannii 5075 (MBC > 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 16 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC > 128 ¦ÌM)."	[Ref.29307492] The peptide showed 3.1% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21644	SMLAYVDKNDHINPPHSPRS	20	SLAY-P14	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 32 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 32 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 64 ¦ÌM)."	[Ref.29307492] The peptide showed 1.5% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21645	DATPHAALFFTVKDHTAGDN	20	SLAY-P15	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 32 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 64 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 32 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 64 ¦ÌM)."	[Ref.29307492] The peptide showed 0.6% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21646	SDDAQRCYPHNRTPFTYTYI	20	SLAY-P16	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 32 ¦ÌM), Acinetobacter baumannii 5075 (MBC > 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 16 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC = 32 ¦ÌM)."	[Ref.29307492] The peptide showed 3.3% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21647	EPCSPKNNYHDLFYRT	16	SLAY-P17	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Slight antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 128 ¦ÌM), Acinetobacter baumannii 5075 (MBC > 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 128 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC > 128 ¦ÌM)."	[Ref.29307492] The peptide showed 1.7% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21648	CNPLNGADRRTDSFPRFTVI	20	SLAY-P18	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC = 128 ¦ÌM), Acinetobacter baumannii 5075 (MBC > 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 64 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC > 128 ¦ÌM)."	[Ref.29307492] The peptide showed 1.7% hemolysis against human red blood cells at 50 ¦ÌM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21649	TCRTNRPCFYDLDLNVCRCS	20	SLAY-P3	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Slight antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC > 128 ¦ÌM), Acinetobacter baumannii 5075 (MBC = 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC > 128 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC > 128 ¦ÌM)."	[Ref.29307492] No hemolytic activity information found.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP21650	YYNPLPHDCGRDNNTDICSR	20	SLAY-P5	No entry found	N/A	N/A	Synthetic construct after SLAY screening and prediction	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Unknown	Not mentioned	None	Function: Slight antibacterial activity against Gram-negative bacteria.	"[Ref.29307492] Gram-negative bacteria: E. coli W3110 (MBC > 128 ¦ÌM), Acinetobacter baumannii 5075 (MBC > 128 ¦ÌM), Pseudomonas aeruginosa 14 (MBC = 128 ¦ÌM), E. coli conferring New Delhi metallo-beta-lactamase (MBC > 128 ¦ÌM)."	[Ref.29307492] No hemolytic activity information found.	Linear	Free	Free	None	L	No cytotoxicity information found	Unknown	29307492	Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.	"Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies"	Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries
DRAMP04654	IKLSPETKDNLKKVLKGAIKGAIAVAKMV	29	Hymenochirin-1B	Not found	Unknown		Hymenochirus boettgeri (Congo dwarf clawed frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Experimental evidence at transcript level	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 12.5 ¦ÌM), S. aureus ATCC 25923 (MIC = 12.5 ¦ÌM), S.epidermidis RP62A (MIC = 3.1 ¦ÌM), S.epidermidis RP62A/1 (MIC = 1.6 ¦ÌM), C.albicans ATCC 90028 (MIC = 100 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 25 ¦ÌM), A. baumannii (MIC = 6.25 ¦ÌM), S. maltophilia (MIC = 6.25 ¦ÌM), K. pneumoniae (MIC = 25 ¦ÌM), P. aeruginosa (MIC = 50 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM)."	[Ref.24172540] LC?? = 213 ¡À 18 ¦ÌM against freshly prepared human erythrocytes.											
DRAMP28985	GIKKFLKSXKKFVKXFK	17	peptide 1 (Derived from Mag2)	No entry found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helix in 20 mM PBS solution (pH = 7.4) with 1% SDS at peptide concentrations of 100 ¦ÌM	No detailed structure description	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria	"[Ref.33466998] Gram-positive bacteria: Staphylococcus aureus (MIC = 12.5 ¦ÌM). 
##Gram-negative bacteria: Escherichia coli (MIC = 3.125 ¦ÌM), Pseudomonas aeruginosa (MIC = 3.125 ¦ÌM), 
multiple-drug resistant P.aeruginosa (MIC = 3.125 ¦ÌM)"	[Ref.33466998] It has hemolysis against human red blood cells at 50 ¦ÌM	Linear	Free	Amidation	The X (position: 9 and 15) in sequence indicate Aib residues (2-Aminoisobutyric acid)	L	No cytotoxicity information found in the reference		33466998	Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444.	"Motoharu Hirano,?Chihiro Saito,?Hidetomo Yokoo,?Chihiro Goto,?Ryuji Kawano,?Takashi Misawa,?Yosuke Demizu"	Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence
DRAMP29028	KLLKKAGKLLKKAGKLLKKAG	21	Stripe	No entry found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-Helix content = 42% in 20 mM phosphate buffered saline (PBS) solution (pH 7.4), with 1% sodium dodecyl sulfate"	No detailed structure description found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
The 'Stripe' is a rationally-designed amphipathic helical AMP comprising natural amino acids: the AMP has hydrophobic Ala/Leu on one side of the helix and cationic Lys residues on the other. It has great antimicrobial activity and weak hemolysis. However, Stripe was compeletely degraded within an hour after incubation with proteinase K at 37¡æ, which means a bad stability."	"[Ref.33369262] Gram-positive bacteria: Staphylococcus aureus NBRC13276 (MIC = 12.5 ¦ÌM) ;##Gram-negative bacteria: Escherichia coli DH5¦Á (MIC = 3.125 ¦ÌM), Pseudomonas aeruginosa NBRC13275 (MIC = 3.125 ¦ÌM), multidrug-resistant Pseudomonas aeruginosa ATCCBAA-2111 (MDRP) (MIC = 3.125 ¦ÌM)"	[Ref.33369262] Stripe showed no hemolytic activity up to a concentration of 100 ¦ÌM.	Linear	Free	Free	None	L	No cytotoxicity information found in the reference		33369262	Chempluschem. 2020 Dec;85(12):2731-2736. doi: 10.1002/cplu.202000749.	"Motoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa, Yosuke Demizu"	"Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing ¦Á,¦Á-Disubstituted Amino Acids or Side-Chain Stapling"
DRAMP29029	KLLKKGGKLLKKGGKLLKKGG	21	Stripe-based foldamer peptide 1	No entry found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	"¦Á-Helix content = 25% in 20 mM phosphate buffered saline (PBS) solution (pH 7.4), with 1% sodium dodecyl sulfate"	"[Ref.33369262] Conversely, the Gly-substitutde peptide 1 showed weaker spectral intensity than other peptides, which suggests a decrease in helicity."	None	"Function: Antibacterial activity against Gram-negative bacteria.
It is a helical foldmer peptide based on ""Stripe"" (an AMP  manually designed) by substituting Ala (position: 6, 13 and 20) with Gly. The peptide was less active than Stripe against four bacteria: S.aureus, E.coli, P.aeruginosa, MDRP. "	"[Ref.33369262] Gram-positive bacteria: Staphylococcus aureus NBRC13276 (MIC > 50 ¦ÌM) ;##Gram-negative bacteria: Escherichia coli DH5¦Á (MIC = 12.5 ¦ÌM), Pseudomonas aeruginosa NBRC13275 (MIC > 50 ¦ÌM), multidrug-resistant Pseudomonas aeruginosa ATCCBAA-2111 (MDRP) (MIC > 50 ¦ÌM)"	[Ref.33369262] Peptide 1 showed no hemolytic activity up to a concentration of 100 ¦ÌM.	Linear	Free	Free	None	L	No cytotoxicity information found in the reference		33369262	Chempluschem. 2020 Dec;85(12):2731-2736. doi: 10.1002/cplu.202000749.	"Motoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa, Yosuke Demizu"	"Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing ¦Á,¦Á-Disubstituted Amino Acids or Side-Chain Stapling"
DRAMP29030	KLLKKXGKLLKKXGKLLKKXG	21	Stripe-based foldamer peptide 2	No entry found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-Helix content = 31% in 20 mM phosphate buffered saline (PBS) solution (pH 7.4), with 1% sodium dodecyl sulfate"	"[Ref.33369262] As shown in Figure 2, peptides 2, 3, 4 and 5 showed negative maxima at around 208 and 222nm, which suggests that they formed stable ¦Á-helical structures, similar to Stripe."	None	"Function: Antibacterial activity against Gram-negative bacteria.
It is a helical foldmer peptide based on ""Stripe"" (an AMP  manually designed) by introducing hydrophobic ¦Á,¦Á-disubstituted amino acids (Aib). The peptide exhibited two to four times higher antimicrobial activity than Stripe. Besides, it is much more stable than Stripe against proteinase K."	"[Ref.33369262] Gram-positive bacteria: Staphylococcus aureus NBRC13276 (MIC = 3.125 ¦ÌM) ;##Gram-negative bacteria: Escherichia coli DH5¦Á (MIC = 1.56 ¦ÌM), Pseudomonas aeruginosa NBRC13275 (MIC = 1.56 ¦ÌM), multidrug-resistant Pseudomonas aeruginosa ATCCBAA-2111 (MDRP) (MIC = 1.56 ¦ÌM)"	[Ref.33369262] Peptide 2 showed no hemolytic activity up to a concentration of 100 ¦ÌM.	Linear	Free	Free	"The X (position: 6, 13 and 20) in sequence denote Aib residue."	L	No cytotoxicity information found in the reference		33369262	Chempluschem. 2020 Dec;85(12):2731-2736. doi: 10.1002/cplu.202000749.	"Motoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa, Yosuke Demizu"	"Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing ¦Á,¦Á-Disubstituted Amino Acids or Side-Chain Stapling"
DRAMP29031	KLLKKZGKLLKKZGKLLKKZG	21	Stripe-based foldamer peptide 3	No entry found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	"¦Á-Helix content = 49% in 20 mM phosphate buffered saline (PBS) solution (pH 7.4), with 1% sodium dodecyl sulfate"	"[Ref.33369262] As shown in Figure 2, peptides 2, 3, 4 and 5 showed negative maxima at around 208 and 222nm, which suggests that they formed stable ¦Á-helical structures, similar to Stripe."	None	"Function: Antibacterial activity against Gram-negative bacteria.
It is a helical foldmer peptide based on ""Stripe"" (an AMP  manually designed) by introducing hydrophobic ¦Á,¦Á-disubstituted amino acids (1-aminocyclohexanecarboxylic acid Ac?c). The peptide showed similar or silightly weaker activity than Stripe."	"[Ref.33369262] Gram-positive bacteria: Staphylococcus aureus NBRC13276 (MIC = 6.25 ¦ÌM) ;##Gram-negative bacteria: Escherichia coli DH5¦Á (MIC = 3.125 ¦ÌM), Pseudomonas aeruginosa NBRC13275 (MIC = 6.25 ¦ÌM), multidrug-resistant Pseudomonas aeruginosa ATCCBAA-2111 (MDRP) (MIC = 12.5 ¦ÌM)"	[Ref.33369262] It exhibits hemolysis at 1.56 ¦ÌM agasint human red blood cells.	Linear	Free	Free	"The Z (position: 6, 13 and 20) in sequence denote Ac?c residue (1-Aminocyclohexanecarboxylic acid)."	L	No cytotoxicity information found in the reference		33369262	Chempluschem. 2020 Dec;85(12):2731-2736. doi: 10.1002/cplu.202000749.	"Motoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa, Yosuke Demizu"	"Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing ¦Á,¦Á-Disubstituted Amino Acids or Side-Chain Stapling"
DRAMP29034	IKLSKETKDNLKKVLKGAIKGAIAVAKMV	29	[P5K]Hymenochirin-1B	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anticancer"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria; Anticancer activity.
Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays"	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 6.25 ¦ÌM), S. aureus ATCC 25923 (MIC = 6.25 ¦ÌM), S.epidermidis RP62A (MIC = 1.6 ¦ÌM), S.epidermidis RP62A/1 (MIC = 1.6 ¦ÌM), C.albicans ATCC 90028 (MIC = 50 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 12.5 ¦ÌM), A. baumannii (MIC = 6.25 ¦ÌM), S. maltophilia (MIC = 3.1 ¦ÌM), K. pneumoniae (MIC = 12.5 ¦ÌM), P. aeruginosa (MIC = 25 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM).##[Ref.30789695] Cancer cell lines: A549 (IC50 = 2.35 ¡À 0.31 ¦ÌM), HCT116 (IC50 = 8.09 ¡À 0.40 ¦ÌM), HepG2 (IC50 = 4.28 ¡À 0.38 ¦ÌM)"	[Ref.24172540] LC?? = 205 ¡À 15 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	None	L	No cytotoxicity information found in the reference		24172540##30789695	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.##ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon##Yulei Li,?Yihan Zhang,?Minghao Wu,?Qi Chang,?Honggang Hu,?Xia Zhao"	"An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties##Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy"
DRAMP29035	IKLSPKTKDNLKKVLKGAIKGAIAVAKMV	29	[E6K]Hymenochirin-1B	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 ¦ÌM), S. aureus ATCC 25923 (MIC = 1.6 ¦ÌM), S.epidermidis RP62A (MIC = 0.8 ¦ÌM), S.epidermidis RP62A/1 (MIC = 0.8 ¦ÌM), C.albicans ATCC 90028 (MIC = 100 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 6.25 ¦ÌM), A. baumannii (MIC = 6.25 ¦ÌM), S. maltophilia (MIC = 1.6 ¦ÌM), K. pneumoniae (MIC = 6.25 ¦ÌM), P. aeruginosa (MIC = 12.5 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM)."	[Ref.24172540] LC?? = 186 ¡À 4 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	None	L	No cytotoxicity information found in the reference		24172540	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon"	An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties
DRAMP29036	IKLSPETKKNLKKVLKGAIKGAIAVAKMV	29	[D9K]Hymenochirin-1B	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anticancer"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria; Anticancer activity.
Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays"	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 ¦ÌM), S. aureus ATCC 25923 (MIC = 3.1 ¦ÌM), S.epidermidis RP62A (MIC = 1.6 ¦ÌM), S.epidermidis RP62A/1 (MIC = 0.8 ¦ÌM), C.albicans ATCC 90028 (MIC = 50 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 6.25 ¦ÌM), A. baumannii (MIC = 3.1 ¦ÌM), S. maltophilia (MIC = 3.1 ¦ÌM), K. pneumoniae (MIC = 12.5 ¦ÌM), P. aeruginosa (MIC = 25 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM).##[Ref.30789695] Cancer cell lines: A549 (IC50 = 1.82 ¡À 0.23 ¦ÌM), HCT116 (IC50 = 6.50 ¡À 0.32 ¦ÌM), HepG2 (IC50 = 4.96 ¡À 0.43 ¦ÌM)."	[Ref.24172540] LC?? = 174 ¡À 12 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	None	L	No cytotoxicity information found in the reference		24172540##30789695	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.##ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon.##Yulei Li,?Yihan Zhang,?Minghao Wu,?Qi Chang,?Honggang Hu,?Xia Zhao."	"An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties.##Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy."
DRAMP29037	IKLSKKTKDNLKKVLKGAIKGAIAVAKMV	29	"[P5K,E6K]Hymenochirin-1B"	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 ¦ÌM), S. aureus ATCC 25923 (MIC = 3.1 ¦ÌM), S.epidermidis RP62A (MIC = 1.6 ¦ÌM), S.epidermidis RP62A/1 (MIC = 0.8 ¦ÌM), C.albicans ATCC 90028 (MIC = 100 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 3.1 ¦ÌM), A. baumannii (MIC = 3.1 ¦ÌM), S. maltophilia (MIC = 1.6 ¦ÌM), K. pneumoniae (MIC = 6.25 ¦ÌM), P. aeruginosa (MIC = 12.5 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM)."	[Ref.24172540] LC?? = 137 ¡À 11 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	None	L	No cytotoxicity information found in the reference		24172540	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon"	An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties
DRAMP29038	IKLSKETKKNLKKVLKGAIKGAIAVAKMV	29	"[P5K,D9K]Hymenochirin-1B"	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anticancer"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria; Anticancer activity.
Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays"	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 6.25 ¦ÌM), S. aureus ATCC 25923 (MIC = 3.1 ¦ÌM), S.epidermidis RP62A (MIC = 1.6 ¦ÌM), S.epidermidis RP62A/1 (MIC = 1.6 ¦ÌM), C.albicans ATCC 90028 (MIC = 50 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 6.25 ¦ÌM), A. baumannii (MIC = 3.1 ¦ÌM), S. maltophilia (MIC = 3.1 ¦ÌM), K. pneumoniae (MIC = 6.25 ¦ÌM), P. aeruginosa (MIC = 12.5 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM).##[Ref.30789695] Cancer cell lines: A549 (IC50 = 1.17 ¡À 0.23 ¦ÌM), HCT116 (IC50 = 4.93 ¡À 0.51 ¦ÌM), HepG2 (IC50 = 2.46 ¡À 0.32 ¦ÌM)."	[Ref.24172540] LC?? = 127 ¡À 9 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	None	L	No cytotoxicity information found in the reference		24172540##30789695	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.##ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon.##Yulei Li,?Yihan Zhang,?Minghao Wu,?Qi Chang,?Honggang Hu,?Xia Zhao."	"An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties.##Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Nov"
DRAMP29039	IKLSPKTKKNLKKVLKGAIKGAIAVAKMV	29	"[E6K,D9K]Hymenochirin-1B"	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,
Immunomodulatory, Anti-inflammatory"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	"Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.
The peptide, at a concentration of 2.5 ¦ÌM, significantly (P<0.05) stimulates the production of the anti-inflammatory IL-4 and IL-10 but is without significant effect on production of the pro-inflammatory cytokines TNF-¦Á and IL-17"	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 ¦ÌM), S. aureus ATCC 25923 (MIC = 1.6 ¦ÌM), S.epidermidis RP62A (MIC = 1.6 ¦ÌM), S.epidermidis RP62A/1 (MIC = 0.8 ¦ÌM), C.albicans ATCC 90028 (MIC = 50 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 3.1 ¦ÌM), A. baumannii (MIC = 3.1 ¦ÌM), S. maltophilia (MIC = 1.6 ¦ÌM), K. pneumoniae (MIC = 3.1 ¦ÌM), P. aeruginosa (MIC = 6.25 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM)."	[Ref.24172540] LC?? = 85 ¡À 5 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	None	L	No cytotoxicity information found in the reference		24172540	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon"	An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties
DRAMP29040	IKLSPkTKDNLKKVLKGAIKGAIAVAKMV	29	[E6k]Hymenochirin-1B	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 ¦ÌM), S. aureus ATCC 25923 (MIC = 3.1 ¦ÌM), S.epidermidis RP62A (MIC = 1.6 ¦ÌM), S.epidermidis RP62A/1 (MIC = 0.8 ¦ÌM), C.albicans ATCC 90028 (MIC = 100 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 3.1 ¦ÌM), A. baumannii (MIC = 3.1 ¦ÌM), S. maltophilia (MIC = 3.1 ¦ÌM), K. pneumoniae (MIC = 6.25 ¦ÌM), P. aeruginosa (MIC = 12.5 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM)."	[Ref.24172540] LC?? = 188 ¡À 8 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	¢ÙIntroduction of D-amino acid(s). (Look at 'Stereochemistry')	Mixed (D-Lys6)	No cytotoxicity information found in the reference		24172540	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon"	An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties
DRAMP29041	IKLSPETKkNLKKVLKGAIKGAIAVAKMV	29	[D9k]Hymenochirin-1B	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 6.25 ¦ÌM), S. aureus ATCC 25923 (MIC = 6.25 ¦ÌM), S.epidermidis RP62A (MIC = 0.8 ¦ÌM), S.epidermidis RP62A/1 (MIC = 0.8 ¦ÌM), C.albicans ATCC 90028 (MIC = 100 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 6.25 ¦ÌM), A. baumannii (MIC = 3.1 ¦ÌM), S. maltophilia (MIC = 3.1 ¦ÌM), K. pneumoniae (MIC = 6.25 ¦ÌM), P. aeruginosa (MIC = 25 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM)."	[Ref.24172540] LC?? > 400 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	¢ÙIntroduction of D-amino acid(s). (Look at 'Stereochemistry')	Mixed (D-Lys9)	No cytotoxicity information found in the reference		24172540	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon"	An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties
DRAMP29042	IKLSPkTKkNLKKVLKGAIKGAIAVAKMV	29	"[E6k,D9k]Hymenochirin-1B"	Not found	N/A	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helical (most likely)	No structure indentification experiment and detailed structure description found	None	Function: Antibacterial activity against Gram-positive and Gram-negative bacteria.	"[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 ¦ÌM), S. aureus ATCC 25923 (MIC = 1.6 ¦ÌM), S.epidermidis RP62A (MIC = 0.8 ¦ÌM), S.epidermidis RP62A/1 (MIC = 0.8 ¦ÌM), C.albicans ATCC 90028 (MIC = 100 ¦ÌM);##Gram-negative bacteria: E.coli (MIC = 3.1 ¦ÌM), A. baumannii (MIC = 1.6 ¦ÌM), S. maltophilia (MIC = 1.6 ¦ÌM), K. pneumoniae (MIC = 3.1 ¦ÌM), P. aeruginosa (MIC = 6.25 ¦ÌM), P.mirabilis (MIC > 100 ¦ÌM)."	[Ref.24172540] LC?? = 302 ¡À 21 ¦ÌM against freshly prepared human erythrocytes.	Linear	Free	Amidation	¢ÙIntroduction of D-amino acid(s). (Look at 'Stereochemistry')	Mixed (D-Lys6 and D-Lys9)	No cytotoxicity information found in the reference		24172540	Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.	"Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon"	An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties
DRAMP29043	VDKPPYLPRPRPPRRIYNR	19	Oncocin (variant of Oncopeltus antibacterial peptide 4)	No entry found	Not found	N/A	"Synthetic construct (Oncocin is a variant of the 2 kDa Oncopeltus antibacterial peptide 4, which was originally isolated from oncopeltus fasciatus (milkweed bug))"	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Not found	Not found	None	Comment: Oncocin inhibits bacterial protein translation by targeting the ribosome.	"[Ref.20565063] Gram-negative pathogens: P.aeruginosa DSM3227 (MIC = 4 ¦Ìg/mL), P. aeruginosa Walter (MIC = 8 ¦Ìg/mL), P. aeruginosa ATCC27853 (MIC = 4 ¦Ìg/mL), P. aeruginosa PAO1 (MIC = 2 ¦Ìg/mL), P. aeruginosa 60811001 (MIC = 2 ¦Ìg/mL), P. aeruginosa 60909001 (MIC = 2 ¦Ìg/mL), P. aeruginosa 61118003 (MIC = 2 ¦Ìg/mL), P. aeruginosa 70108001 (MIC = 4 ¦Ìg/mL), E. coli 70329001 (MIC = 1 ¦Ìg/mL), E. coli 70430001 (MIC = 1 ¦Ìg/mL), E. coli 70419002 (MIC = 8 ¦Ìg/mL), E. coli 70502001 (MIC = 1 ¦Ìg/mL), E. coli Neumann (MIC = 2 ¦Ìg/mL), E. coli 205024 (MIC = 4 ¦Ìg/mL), E. coli 455/7 (MIC = 0.5 ¦Ìg/mL), E. coli 8474 (MIC = 0.5 ¦Ìg/mL), K. pneumoniae DSM681 (MIC = 0.25 ¦Ìg/mL), K. pneumoniae 57 USA (MIC = 0.25 ¦Ìg/mL), K. pneumoniae 63 (MIC = 8 ¦Ìg/mL), K. pneumoniae 8085 (MIC = 0.5 ¦Ìg/mL), K. pneumoniae ATCC12657 (0.5 ¦Ìg/mL), K. pneumoniae ATCC27799 (MIC = 1 ¦Ìg/mL), A. baumannii ICB14067 (MIC = 1 ¦Ìg/mL), A. baumannii ICB14072 (MIC = 1 ¦Ìg/mL), A. baumannii ICB14073 (MIC = 2 ¦Ìg/mL), A. baumannii ICB9250 (MIC = 0.5 ¦Ìg/mL), A. baumannii M17 (MIC = 1 ¦Ìg/mL), E. cloacae 34654 (MIC = 0.25 ¦Ìg/mL), E. cloacae Ha088 (MIC = 0.125 ¦Ìg/mL), E. cloacae Ha089 (0.125 ¦Ìg/mL), E. cloacae Ha185 (MIC = 0.5 ¦Ìg/mL), E. cloacae Ha89 (MIC = 0.25 ¦Ìg/mL), P. vulgaris ICB9081 (MIC = 4 ¦Ìg/mL), P. vulgaris ICB9095 (MIC = 4 ¦Ìg/mL), Stenotrophomonas ICB308054 (MIC = 32 ¦Ìg/mL), Stenotrophomonas ICB7569 (MIC = 8 ¦Ìg/mL), Stenotrophomonas ICB7789 (MIC = 32 ¦Ìg/mL)"	[Ref.20565063]None of the tested peptides showed any hemolytic activity against human erythrocytes in the studied peptide concentration range up to 600 ¦Ìg/mL.	Linear 	Free	Amidation	None	L	"[Ref.20565063] Oncocin showed no toxic effects on HeLa- or neuronal-cell-like differentiated SH-SY5Y cells at a peptide concentration of 600 ¦Ìg/mL, which was about 100-fold above their MIC-values against E.coli BL21 AI."	Bacterial ribosome	20565063	J Med Chem. 2010 Jul 22;53(14):5240-7. doi: 10.1021/jm100378b.	"Daniel Knappe, Stefania Piantavigna, Anne Hansen, Adam Mechler, Annegret Binas, Oliver Nolte, Lisandra L Martin, Ralf Hoffmann"	Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens
DRAMP29044	KFFRKLKKSVKKRAKKFFKKPRVIGVSIPF	30	Cbf-K-16 (variant of BF-30)	No entry found	Not found	N/A	"Synthetic construct (Cbf-K16 is a variant of BF-30, which was found in the venom of the snake bungarus fasciatus)"	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	"Comment: Cbf-K16 possessed effective antimicrobial and anti-inflammatory activities and downregulated the expression of adhesion- and cytotoxin-associated genes of drug-resistant H. pylori SS1, making it a potential candidate for anti-infective therapy."	"[Ref.31704464] Gram-negative drug-resistant clinical isolates: H. pylori SS1 (MIC = 16 ¦Ìg/mL, MBC = 32 ¦Ìg/mL); Gram -negative bacteria: H. pylori 26695 (MIC = 32 ¦Ìg/mL, MBC = 64 ¦Ìg/mL), H. pylori 11637 (MIC = 16 ¦Ìg/mL, MBC = 64 ¦Ìg/mL) ##[Ref.27287456] Gram-positive drug-resistant clinical isolates: MRSA strain no.1 (MIC = 32 ¦Ìg/mL), MRSA strain no.2 (MIC = 16 ¦Ìg/mL), S.aureus strain no.1 (MIC = 16 ¦Ìg/mL), S.aureus strain no.2 (MIC = 64 ¦Ìg/mL), S.aureus strain no.3 (MIC = 8 ¦Ìg/mL), S.aureus strain no.4 (MIC = 16 ¦Ìg/mL), S.aureus strain no.5 (MIC = 4 ¦Ìg/mL), S.aureus strain no.6 (MIC = 8 ¦Ìg/mL), S.aureus strain no.7 (MIC = 32 ¦Ìg/mL), S.epidermidis strain no.1 (MIC = 16 ¦Ìg/mL), S.epidermidis strain no.2 (MIC = 32 ¦Ìg/mL);## Gram-positive bacteria: S.aureus ATCC 25923 (MIC = 8 ¦Ìg/mL);## Gram-negative drug-resistant clinical isolates: E.coli strain no.1 (MIC = 4 ¦Ìg/mL), E.coli strain no.2 (MIC = 8 ¦Ìg/mL), E.coli strain no.3 (MIC = 8 ¦Ìg/mL); ##Gram-negative bacteria: E.coli ATCC 25922 (MIC = 4 ¦Ìg/mL)"	[Ref.27287456]Cbf-K-16 has low hemolytic activity	Linear	Free	Free	None	L	[Ref.27287456] Cbf-K-16 has low cytotoxicity.	Genomic DNA	31704464##27287456	Microb Pathog. 2020 Jan;138:103847. doi: 10.1016/j.micpath.2019.103847. Epub 2019 Nov 5.##Arch Pharm Res. 2016 Jul;39(7):978-88. doi: 10.1007/s12272-016-0769-x. Epub 2016 Jun 10.	"Jiang M, Ma L, Huang Y, Wu H, Dou J, Zhou C##Bo Li, Wei Kang, Hanhan Liu, Yanrong Wang, Changzhong Yu, Xinyi Zhu, Jie Dou, Haibo Cai, Changlin Zhou"	Antimicrobial activities of peptide Cbf-K 16 against drug-resistant Helicobacter pylori infection in vitro and in vivo. ##The antimicrobial activity of Cbf-K16 against MRSA was enhanced by ¦Â-lactamantibiotics through cell wall non-integrity.
DRAMP29045	SQRKLAAKLTSKGGGRLLRPLLQLLKQKLR	30	PA2-GNU7	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Helix-loop-helix structure	¢ÙMolecular modelling showed that the hybrid peptide was predicted to form a helix-loop-helix structure. ¢ÚThe hybrid peptide PA2-GNU7 was constructed by joining the PA2 peptide (SQRKLAAKLTSK) to GNU7 (RLLRPLLQLLKQKLR) with a short linker (Gly?¡Á?3).	None	Comment: The specific binding activity of PA2-GNU7 against P. aeruginosa was derived from the binding activity of PA2 peptide.	"[Ref.31704464] Gram-positive bacteria: S. aureus (MIC = 2 ¦ÌM);##Gram-negative bacteria: P. aeruginosa (MIC = 2 ¦ÌM), E. coli (MIC = 1 ¦ÌM), S. typhimurium (MIC = 2 ¦ÌM); ##Fungi: C.albicans (MIC = 8 ¦ÌM)"	[Ref.31678742]PA2-GNU7 was not toxic to human RBCs at the tested concentrations (0 - 65 ¦ÌM).The haemolysis was less than 2.5 % up to the concentration of 65 ¦ÌM.	Linear 	Free	Free	None	L	Not found	"Outer membrane proteins (OMPs) like OprF, the major outer membrane porin of P.aeruginosa"	31678742	Eur J Med Chem. 2020 Jan 1;185:111814. doi: 10.1016/j.ejmech.2019.111814. Epub 2019 Oct 25.	"Kim H, Jang JH, Kim SC, Cho JH."	Development of a novel hybrid antimicrobial peptide for targeted killing of Pseudomonas aeruginosa 
DRAMP29046	FRKKWNKWALSR	12	PAMP(9-20) ( the C-terminal 12-residues of PAMP)	"P53366, O62827, P43145, P35318"	Belongs to the?adrenomedullin family	ADM	Homo sapiens et.al	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	¦Á-helical (most likely)	Not found	None	"Function: Kuwasako et al. identified the C-terminal 12-residues of PAMP [PAMP(9¨C20)] in porcine adrenal medulla as a major endogenous active peptide of the AM precursor and demonstrated that its hypotensive activity is comparable to that of PAMP. PAMP(9-20) can acts as an potent antimicrobial peptide which is more selective than melittin, and antimicrobial action of PAMP(9-20) seems to exert via an intracellular target. "	"[Ref.32439180] Gram-negative bacteria: E. coli (MIC = 4 ¦ÌM), P. aeruginosa (MIC = 16 ¦ÌM), S. typhimurium (MIC = 4 ¦ÌM)##Gram-positive bacteria:B. subtilis (MIC = 8 ¦ÌM), S. epidermidis (MIC = 8 ¦ÌM), S. aureus(MIC = 16 ¦ÌM)"	[Ref.32439180]HC10 > 256 ¦ÌM against sheep RBCs.Note: HC10 is the minimum peptide concentration that caused >10% hemolysis of sheep red blood cells.	Linear 	Free	Amidation	None	L	Not found	Bacterial DNA	32439180	Biochem Biophys Res Commun. 2020 Jun 30;527(3):744-750. doi: 10.1016/j.bbrc.2020.04.063. Epub 2020 May 18.	"Ajish C, Yang S, Kumar SD, Shin SY. "	"Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism"
DRAMP29047	ARLDVASEFRKKWNKWALSR	20	PAMP (Proadrenomedullin N-terminal 20 peptide)	"P35318, E9PML4, L5L428"	Belongs to the?adrenomedullin family	ADM	Homo sapiens et.al	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Protein level	¦Á-helical	Not found	2FLY	"Introduction: Proadrenomedullin N-terminal 20 peptide (PAMP) is a biologically active molecule (20 amino acid residues) produced by post-translational enzymatic processing of the common precursor of adrenomedullin (AM), a 185-amino acid proadrenomedullin molecule. PMAP can bee found in various types.  Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. PAMP can acts as an potent antimicrobial peptide which is more selective than melittin, and antimicrobial action of PAMP seems to exert via an intracellular target."	"[Ref.32439180] Gram-negative bacteria: E. coli (MIC = 8 ¦ÌM), P. aeruginosa (MIC = 32 ¦ÌM), S. typhimurium (MIC = 16 ¦ÌM)##Gram-positive bacteria:B. subtilis (MIC = 8 ¦ÌM), S. epidermidis (MIC = 8 ¦ÌM), S. aureus(MIC = 16 ¦ÌM)"	[Ref.32439180]HC10 > 256 ¦ÌM against sheep RBCs.Note: HC10 is the minimum peptide concentration that caused >10% hemolysis of sheep red blood cells.	Linear 	Free	Amidation	None	L	Not found	Bacterial DNA	32439180	Biochem Biophys Res Commun. 2020 Jun 30;527(3):744-750. doi: 10.1016/j.bbrc.2020.04.063. Epub 2020 May 18.	"Ajish C, Yang S, Kumar SD, Shin SY. "	"Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism"
DRAMP29048	KIAKRIWKILRRR	13	PA-13	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helical	Not found	None	"Function: PA-13 exhibited potent antibacterial activity against P. aeruginosa, including multidrug resistant strains, via penetration through the bacteria¡¯s membrane and causing depolarization, permeabilization and rupture of membranes, and subsequent leakage of intracellular contents and cell death. The peptide displayed low hemolytic and cytotoxic activities against mammalian cells suggesting a therapeutic potential. Furthermore, PA-13 showed anti-inflammatory activity via LPS neutralization. Note: It maintained antimicrobial activity in the presence of physiological salts and displayed rapid binding and penetration activity which resulted in membrane depolarization and permeabilization.?"	"[Ref.32499514] Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC = 3.91 ?g/ml), Escherichia coli ATCC 25922 (MIC = 31.25 ?g/ml), Escherichia coli O157:H7 MT strain (MIC = 31.25 ?g/ml), Shigella sonnei ATCC 11060 (MIC = 3.91 ?g/ml), Salmonella Typhimurium ATCC 13311 (MIC = 1.95 ?g/ml), Vibrio cholera O1 Inaba DMST 16261 (MIC = 31.25 ?g/ml), Acinetobacter baumannii MT strain (MIC = 7.81 ?g/ml). ##Clinically isolated MDR P. aeruginosa: P. aeruginosa No.1 (3.91 ¦Ìg/mL), P. aeruginosa No.2	(7.81¦Ìg/mL), P. aeruginosa No.3 (7.81 ¦Ìg/mL), P. aeruginosa No.4 (7.81 ¦Ìg/mL), P. aeruginosa No.5 (7.81 ¦Ìg/mL), P. aeruginosa No.6 (7.81 ¦Ìg/mL), P. aeruginosa No.7 (7.81 ¦Ìg/mL), P. aeruginosa No.8 (7.81 ¦Ìg/mL), P. aeruginosa No.9 (7.81 ¦Ìg/mL), P. aeruginosa No.10 (7.81 ¦Ìg/mL), P. aeruginosa No.11 (7.81 ¦Ìg/mL), P. aeruginosa No.12 (3.91 ¦Ìg/mL), P. aeruginosa No.13 (15.63 ¦Ìg/mL), P. aeruginosa No.14 (7.81 ¦Ìg/mL),##Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC = 62.5 ?g/ml) Staphylococcus epidermidis ATCC 12228 (MIC = 3.91 ?g/ml), Bacillus cereus ATCC 11778 (MIC = 15.63 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC = 250 ?g/ml), Listeria monocytogenes 10403?s (MIC = 3.91 ?g/ml)"	"[Ref.32499514]MHC = 125 ¦Ìg/mL. Note:MHC is the minimum concentration that caused 10% hemolysis of human red blood cells (hRBC). When no 10% hemolysis was observed at 250??g/ml, a value of 500??g/ml was used to calculate the therapeutic index."	Linear 	Free	Amidation	None	L	"[Ref.32499514]Cytotoxic activity of PA-13 against the L929 mouse fibroblast cell line was determined by a colorimetric MTT viability assay. At the MIC (3.91??g/ml), the cell survival was up to 90%. Even at the maximum concentration (250??g/ml), the survival was common (81.29%). Melittin, used as a positive control, showed a strong and dose-dependent cytotoxic effect; no living cells were detected at 62.5??g/ml. Peptide PA-13 displayed very little cytotoxicity on L929 cells when compared to melittin."	Membrane	32499514	Sci Rep. 2020 Jun 4;10(1):9117. doi: 10.1038/s41598-020-65688-5.	"Klubthawee N, Adisakwattana P, Hanpithakpong W, Somsri S, Aunpad R"	"A novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas aeruginosa "
DRAMP29049	ALLKRIKTLL	10	Ano-1¦Â (variant of Anoplin)	No entry found	Not found	N/A	"Synthetic construct (Ano-1¦Â is a variant of Anoplin, which is a linear cationic ¦Á-helical AMPs isolated from the venom sac of anoplius samariensis(solitary spider wasps))"	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	75.3% ¦Á-helical content in 30 mM SDS	"As shown in?Fig. 1, the new peptides displayed mostly unordered conformations in the aqueous environment as demonstrated by a negative peak at approximately 195 nm. However, in 30 mM SDS, the new peptides folded typical ¦Á-helical conformations, as evidenced by a characteristic positive peak at approximately 195 nm and double negative peaks at approximately 208 nm and 222 nm.?"	None	"Comment: the incorporation of ¦Â-Ala had significant influence on the antimicrobial activity of peptides mainly due to the changes of hydrophobicity and net positive charge. Ano-1¦Â exhibited good antimicrobial potency, which was stable under physiological conditions and displayed preferable in vivo antimicrobial activity with less acute toxicity. In particular, Ano-1¦Â showed low tendency to develop bacterial resistance in contrast to conventional antibiotics rifampicin and gentamicin, and they exhibited better anti-biofilm activity and synergistic or additive effects in combination with conventional antibiotics. Ano-1¦Â might stands as a promising antimicrobial candidate to overcome increasing bacterial resistance, and the incorporation of ¦Â-Ala was a reasonable strategy for the development of promising antimicrobial agents."	"[Ref.32654770] Gram-negative multidrug-resistant bacteria: P. aeruginosa 119 (MIC = 8 ¦ÌM or 8.93 ¦Ìg/mL), P. aeruginosa 124 (MIC = 8 ¦ÌM or 8.93 ¦Ìg/mL), P. aeruginosa 86 (MIC = 4 ¦ÌM or 4.47 ¦Ìg/mL); ##Gram-negative bacteria: P. aeruginosa ATCC 27853 (MIC = 8 ¦ÌM or 8.93 ¦Ìg/mL), P. aeruginosa ATCC 9027 (MIC = 8 ¦ÌM or 8.93 ¦Ìg/mL), E. coli ATCC 25922  (MIC = 32 ¦ÌM or 35.72 ¦Ìg/mL), K. pneumonia ATCC 700603 (MIC = 32 ¦ÌM or 35.72 ¦Ìg/mL), A. baumannii ATCC 19606 (MIC = 64 ¦ÌM or 71.44 ¦Ìg/mL); ##Gram-positive bacteria: S. aureus ATCC 25923 (MIC = 128 ¦ÌM or 142.88 ¦Ìg/mL), S. epidermidis ATCC 12228 (MIC = 8 ¦ÌM or 8.93 ¦Ìg/mL)"	"[Ref.32654770]Ano-1¦Â induced inappreciable hemolytic activity with less than 5 % hemolysis at all the tested concentrations and HC > 256 ¦ÌM. Note: Minimum hemolysis concentration (HC, ¦ÌM) was defined as the minimal peptide concentration induced 10 % hemolysis."	Linear 	Free	Amidation	[Ref.32654770] The residue A at position 1 indicates the ¦Â-Ala	L	"[Ref.32654770]After 1 h of incubation, Ano-1¦Â, similar to their parent peptide anoplin, maintained more than 80 % cell viability of the two cells at all tested concentrations. After incubating for 24 h, Ano-1¦Â still maintained more than 80 % cell viability of HEK 293 T cells at all tested concentrations but displayed cytotoxicity against Hela cells at the highest concentration (256 ¦ÌM). The cell viability of Hela after 24 h of incubation is around 80%."	Membrane	32654770	Int J Med Microbiol. 2020 Jul;310(5):151433. doi: 10.1016/j.ijmm.2020.151433. Epub 2020 May 27.	"Zhong C, Zhu Y, Zhu N, Liu T, Gou S, Zhang F, Yao J, Xie J, Ni J"	Synthesis and anti-pseudomonal activity of new ?-Ala modified analogues of the antimicrobial peptide anoplin
DRAMP29050	GLLKRIKALL	10	Ano-8¦Â (variant of Anoplin)	No entry found	Not found	N/A	"Synthetic construct (Ano-1¦Â is a variant of Anoplin, which is a linear cationic ¦Á-helical AMPs isolated from the venom sac of anoplius samariensis(solitary spider wasps))"	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	72.82% ¦Á-helical content in 30 mM SDS	"As shown in?Fig. 1, the new peptides displayed mostly unordered conformations in the aqueous environment as demonstrated by a negative peak at approximately 195 nm. However, in 30 mM SDS, the new peptides folded typical ¦Á-helical conformations, as evidenced by a characteristic positive peak at approximately 195 nm and double negative peaks at approximately 208 nm and 222 nm.?"	None	"Comment: the incorporation of ¦Â-Ala had significant influence on the antimicrobial activity of peptides mainly due to the changes of hydrophobicity and net positive charge. Ano-8¦Â exhibited good antimicrobial potency, which was stable under physiological conditions and displayed preferable in vivo antimicrobial activity with less acute toxicity. In particular, Ano-8¦Â showed low tendency to develop bacterial resistance in contrast to conventional antibiotics rifampicin and gentamicin, and they exhibited better anti-biofilm activity and synergistic or additive effects in combination with conventional antibiotics. Ano-8¦Â might stands as a promising antimicrobial candidate to overcome increasing bacterial resistance, and the incorporation of ¦Â-Ala was a reasonable strategy for the development of promising antimicrobial agents."	"[Ref.32654770] Gram-negative multidrug-resistant bacteria: P. aeruginosa 119 (MIC = 8 ¦ÌM or 9.00 ¦Ìg/mL), P. aeruginosa 124 (MIC = 16 ¦ÌM or 17.98 ¦Ìg/mL), P. aeruginosa 86 (MIC = 8 ¦ÌM or 9.00 ¦Ìg/mL); ##Gram-negative bacteria: P. aeruginosa ATCC 27853 (MIC = 4 ¦ÌM or 4.50 ¦Ìg/mL), P. aeruginosa ATCC 9027 (MIC = 8 ¦ÌM or 9.00 ¦Ìg/mL), E. coli ATCC 25922  (MIC = 32 ¦ÌM or 36 ¦Ìg/mL), K. pneumonia ATCC 700603 (MIC = 128 ¦ÌM or 144 ¦Ìg/mL), A. baumannii ATCC 19606 (MIC > 128 ¦ÌM or 144 ¦Ìg/mL); ##Gram-positive bacteria: S. aureus ATCC 25923 (MIC = 128 ¦ÌM or 144 ¦Ìg/mL), S. epidermidis ATCC 12228 (MIC = 16 ¦ÌM or 18 ¦Ìg/mL)"	"[Ref.32654770]Ano-8¦Â induced inappreciable hemolytic activity with less than 5 % hemolysis at all the tested concentrations and HC > 256 ¦ÌM. Note: Minimum hemolysis concentration (HC, ¦ÌM) was defined as the minimal peptide concentration induced 10 % hemolysis."	Linear 	Free	Amidation	[Ref.32654770] The residue A at position 8 indicates the ¦Â-Ala	L	"[Ref.32654770]After 1 h of incubation, Ano-8¦Â, similar to their parent peptide anoplin, maintained more than 80 % cell viability of the two cells at all tested concentrations. After incubating for 24 h, Ano-8¦Â still maintained more than 80 % cell viability of HEK 293 T cells at all tested concentrations but displayed cytotoxicity against Hela cells at the highest concentration (256 ¦ÌM). The cell viability of Hela after 24 h of incubation is around 70%"	Membrane	32654770	Int J Med Microbiol. 2020 Jul;310(5):151433. doi: 10.1016/j.ijmm.2020.151433. Epub 2020 May 27.	"Zhong C, Zhu Y, Zhu N, Liu T, Gou S, Zhang F, Yao J, Xie J, Ni J"	Synthesis and anti-pseudomonal activity of new ?-Ala modified analogues of the antimicrobial peptide anoplin
DRAMP29052	FLGALFKVASKLVPAAICSISKKC	24	Brevinin-1GHd	A0A6M4CA40	Belongs to the?frog skin active peptide (FSAP) family.?Brevinin subfamily	N/A	Sylvirana guentheri (Gunther's frog) (Rana guentheri)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Transcript level	¦Á-helical	"The results of CD spectroscopy revealed that Brevinin-1GHd adopt a random coil structure in an aqueous environment, while forming an alpha-helix structure in a membrane-mimetic environment."	None	"Comment: Brevinin-1GHd with its excellent antimicrobial and anticancer activities is a promising candidate for a novel antibiotic agent, and study of its structure activity relationships also provided a rational template for further research and peptide analog design. In the reference, the example of Brevinin-1GHd is used to challenge the importance of ""Rana-Box"", which appears in many AMPs originating from frogs and contains an intermolecular disulfide bridge at the C-terminus of the peptide and seven to nine amino acid residues."	"[Ref.32347293] Gram-positive bacteria: S. aureus (MIC = 2 ¦ÌM/MBC= 4 ?M), MRSA(MIC = 4 ¦ÌM/MBC = 4?M); ##Gram-negative: E. coli(MIC = 8 ¦ÌM/MBC = 8 ?M), P. aeruginosa(MIC = 32 ¦ÌM/MBC = 32?M); ##Fungi: C. albicans(MIC = 4 ¦ÌM/MBC = 8?M£©"	"[Ref.32347293] Brevinin-1GHd displayed 13% hemolysis on horse red blood cells at its highest MIC/MBC value of the tested bacteria P. aeruginosa (32 ?M). However, when the concentration increased above 64 ¦ÌM, the hemolytic activity of Brevinin-1GHd also gradually increased. At the concentration of 64, 128, 256 and 512 ¦ÌM, it displayed about 36%, 64%, 83% and 108% hemolysis."	Cyclic 	Free	Free	Free	L	"[Ref.32347293]Brevinin-1GHd showed significant cytotoxicity toward human HMEC-1 and HaCaT cells at concentrations of 0.00001 and 0.0001 M, respectively. Brevinin-1GHd induced one cell viability of 56% on HMEC-1 and the other cell viability of 75% on HaCat."	Cell membrane	32347293	Biosci Rep. 2020 May 29;40(5):BSR20200019. doi: 10.1042/BSR20200019.	"Jiang Y, Wu Y, Wang T, Chen X, Zhou M, Ma C, Xi X, Zhang Y, Chen T, Shaw C, Wang L. "	Brevinin-1GHd: a novel Hylarana guentheri skin secretion-derived Brevinin-1 type peptide with antimicrobial and anticancer therapeutic potential 
DRAMP29053	AKLIPTIAL	9	RcAlb-PepI (designed in silico using as template the amino acid sequence of Rc-2S-Alb)	No entry found	Not found	N/A	Synthetic construct (Rc-2S-Alb comes from Ricinus communis (Castor bean))	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Partially ordered (non-regular) and ¦Á-helical	RcAlb-PepI and RcAlb-PepII in aqueous solution showed SRCD spectra typical of peptides that present major unordered content of secondary structure. The small (albeit significant) shift of the minimum for the RcAlb-PepII spectrum showed a more partially ordered peptide (although non-canonical) compared with RcAlb-PepI. The SRCD spectra of RcAlb-PepI and RcAlb-PepII in the film were characteristics of partially ordered (non-regular) and ¦Á-helix secondary structures.	None	Comment: RcAlb-PepI is safe and apparently effective for its intended use and has great potential for the future development of an antimicrobial agent with the ability to kill or inhibit K. pneumoniae and C. parapsilosis cells.	"[Ref.31678367] Gram-negative bacteria: E. coli (MIC50 = 102 ¦ÌM, MIC90 >  250 ¦ÌM, MBC > 250 ¦ÌM), K. pneumoniae(MIC50 = 121 ¦ÌM, MIC90 > 250 ¦ÌM, MBC > 250 ¦ÌM)##Gram-positive bacteria: S. aureus (MIC50 = 123 ¦ÌM, MIC90 > 250 ¦ÌM, MBC > 250 ¦ÌM)##Yeast: C. albicans (MIC50 = 62 ¦ÌM, MIC90 > 250 ¦ÌM, MFC > 250 ¦ÌM), C. parapsilosis (MIC50 = 14 ¦ÌM, MIC90 = 32 ¦ÌM, MFC = 103 ¦ÌM), C. tropicalis (MIC50 = 21 ¦ÌM, MIC90 = 38 ¦ÌM, MFC = 127 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Free	None	L	Not found	Not found	31678367	Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183092. doi: 10.1016/j.bbamem.2019.183092. Epub 2019 Oct 31.	"Dias LP, Souza PFN, Oliveira JTA, Vasconcelos IM, Ara¨²jo NMS, Tilburg MFV, Guedes MIF, Carneiro RF, Lopes JLS, Sousa DOB"	"RcAlb-PepII, a synthetic small peptide bioinspired in the 2S albumin from the seed cake of Ricinus communis, is a potent antimicrobial agent against Klebsiella pneumoniae and Candida parapsilosis "
DRAMP29054	SLRGCC	6	RcAlb-PepII (designed in silico using as template the amino acid sequence of Rc-2S-Alb)	No entry found	Not found	N/A	Synthetic construct (Rc-2S-Alb comes from Ricinus communis (Castor bean))	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Partially ordered (non-regular) and ¦Á-helical	RcAlb-PepI and RcAlb-PepII in aqueous solution showed SRCD spectra typical of peptides that present major unordered content of secondary structure. The small (albeit significant) shift of the minimum for the RcAlb-PepII spectrum showed a more partially ordered peptide (although non-canonical) compared with RcAlb-PepI. The SRCD spectra of RcAlb-PepI and RcAlb-PepII in the film were characteristics of partially ordered (non-regular) and ¦Á-helix secondary structures.	None	Comment: RcAlb-PepII is safe and apparently effective for its intended use and has great potential for the future development of an antimicrobial agent with the ability to kill or inhibit K. pneumoniae and C. parapsilosis cells.	"[Ref.31678367] Gram-negative bacteria: E. coli (MIC50 = 31 ¦ÌM, MIC90 = 29 ¦ÌM, MBC > 250 ¦ÌM), K. pneumoniae(MIC50 = 11 ¦ÌM, MIC90 = 21 ¦ÌM, MBC = 42 ¦ÌM)##Gram-positive bacteria: S. aureus (MIC50 = 79 ¦ÌM, MIC90 > 250 ¦ÌM, MBC > 250 ¦ÌM)##Yeast: C. albicans (MIC50 = 129 ¦ÌM, MIC90 > 250 ¦ÌM, MFC > 250 ¦ÌM), C. parapsilosis (MIC50 = 9 ¦ÌM, MIC90 = 17 ¦ÌM, MFC = 25 ¦ÌM), C. tropicalis (MIC50 = 29 ¦ÌM, MIC90 = 28 ¦ÌM, MFC = 67 ¦ÌM)"	"[Ref.31678367] RcAlb-PepII was not harmful to human erythrocytes, even at a concentration 10 times higher than the MBC and MFC for K. pneumoniae and C. parapsilosis, respectively."	Linear 	Free	Free	None	L	"[Ref.31678367] At 420?¦ÌM concentration (10 and 16.8 times higher than the MBC and MFC for K. pneumoniae and C. parapsilosis, respectively) RcAlb-PepII reduced only in 21.5% the Vero cell viability"	Intracellular targets	31678367	Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183092. doi: 10.1016/j.bbamem.2019.183092. Epub 2019 Oct 31.	"Dias LP, Souza PFN, Oliveira JTA, Vasconcelos IM, Ara¨²jo NMS, Tilburg MFV, Guedes MIF, Carneiro RF, Lopes JLS, Sousa DOB"	"RcAlb-PepII, a synthetic small peptide bioinspired in the 2S albumin from the seed cake of Ricinus communis, is a potent antimicrobial agent against Klebsiella pneumoniae and Candida parapsilosis "
DRAMP29055	FFPVIGRILNGIL	13	temporin G	P79875	Belongs to the?frog skin active peptide (FSAP) family.?Temporin subfamily.	N/A	Rana temporaria (European common frog)	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antibiofilm"	Protein level	Amphipathic alpha-helical (Uniprot:P79875)	Not found	None	"Function: Amphipathic alpha-helical antimicrobial peptide with activity against Gram-positive bacteria (M.luteus), Gram-negative bacteria (E.coli), and fungi (S.cerevisiae) (PubMed:22439858). Stimulates insulin release from pancreatic beta-cells in a dose-dependent manner, without increasing intracellular calcium (PubMed:29349894). Does not protects BRIN-BD11 beta-cells against cytokine-induced apoptosis (PubMed:29349894). In vivo, intraperitoneal injection together with a glucose load into mice improves glucose tolerance with a concomitant increase in insulin secretion (PubMed:29349894)."	"[Ref.33321906] S. aureus ATCC 25923 biofilm: TG was capable of killing at least 39%, 78% and 87% at 3.12, 6.25, 12.5 and 25 ?M. ##[Ref.22439858] Summary: TG had specific bactericidal activities against E. coli ATCC2592, M. luteus or S. cerevisiae."	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	None	L	[Ref.33321906]TG was shown to be harmless against human keratinocytes at all concentrations tested with a slight cytotoxicity (~20% reduction of metabolically-active cells) at the highest active concentration	Not found	33321906##22439858	Int J Mol Sci. 2020 Dec 10;21(24):9410. doi: 10.3390/ijms21249410.##BMC Biotechnol. 2012 Mar 23;12:10. doi: 10.1186/1472-6750-12-10.	"Casciaro B, Loffredo MR, Cappiello F, Fabiano G, Torrini L, Mangoni ML##Tao Ke, Su Liang, Jin Huang, Han Mao, Jibao Chen, Caihua Dong, Junyan Huang, Shengyi Liu, Jianxiong Kang, Dongqi Liu, Xiangdong Ma"	"The Antimicrobial Peptide Temporin G: Anti-Biofilm, Anti-Persister Activities, and Potentiator Effect of Tobramycin Efficacy Against Staphylococcus aureus.##A novel PCR-based method for high throughput prokaryotic expression of antimicrobial peptide genes"
DRAMP29056	LRCMCIKWWSGKHPK	15	TC19 (derived from the human thrombocidin-1-derived peptide L3)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	Not found	Not found	None	"Comment: TC19 combined low cytotoxicity towards human fibroblasts with efficient and rapid killing in human plasma of MDR strains of several bacterial species of the ESKAPE panel. However, the hemolytic activity data and secondary structure is missing."	"[Ref.32376222] Gram-positive bacteria: E. coli ESBL (LC99.9 = 3.75 ¦ÌM in PT buffer, LC99.9 = 15 ¦ÌM in PBS buffer); ##Gram-negative bacteria: S. aureus JAR060131 (LC99.9 = 3.75 ¦ÌM in PT buffer, LC99.9 = 7.5-15 ¦ÌM in PBS buffer, LC99.9 = 15-30 ¦ÌM in 50% plasma).##Multi-drug resistant (MDR) gram-positive bacteria:  E.faecium LUH10330 (LC99.9 = 1.6(1.6-3.2) ¦ÌM in PBS buffer, LC99.9 =6.4 (3.2-6.4) ¦ÌM in 50% plasma), S.aureus LUH14616 (LC99.9 = 3.2(3.2-6.4) ¦ÌM in PBS buffer, LC99.9 = 12.8 (3.2-12.8) ¦ÌM in 50% plasma).##Multi-drug resistant (MDR) and pan-drug resistant (PDR) gram-negative bacteria: K.pneumoniae LUH8995 (LC99.9 = 1.6(0.8-1.6) ¦ÌM in PBS buffer, LC99.9 = 3.2 ¦ÌM in 50% plasma), A.baumannii RUH875 (LC99.9 = 1.6(1.6-3.2) ¦ÌM in PBS buffer, LC99.9 =6.4 (6.4-12.8) ¦ÌM in 50% plasma), P.aeruginosa LUH15100 (LC99.9 = 4.8(3.2-6.4) ¦ÌM in PBS buffer, LC99.9 > 204.8 ¦ÌM in 50% plasma), E.cloacae LUH15114 (LC99.9 = 25.6 ¦ÌM in PBS buffer, LC99.9 = 204.8 ¦ÌM in 50% plasma)##Note: Results are expressed as the lethal concentration (LC) 99.9%, i.e. the lowest peptide concentration that resulted in >= 99.9% killing of bacteria after 2 h of incubation in PT buffer (10 mM phosphate buffer, pH 7.0, with 1% (v/v) TSB), phosphate buffered saline (PBS, pH 7.4) and in PBS with 50% (v/v) human plasma (one experiment, performed in duplicate). "	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	None	L	"[Ref.32891601]Up to 40 ¦ÌM TC19 did not permeabilize human fibroblasts, whereas at 80 ¦ÌM an increase in PI-positivity was recorded after 4 h of exposure. After 4h of incubation with TC19 at indicated concentration (80 ¦ÌM), PI-uptake by normal human dermal fibroblasts (NHDF) had increased from 5% to 20% comparing to the result after 1h of incubation."	Bacterial membrane	32376222	Biochim Biophys Acta Biomembr. 2020 Aug 1;1862(8):183282. doi: 10.1016/j.bbamem.2020.183282. Epub 2020 May 3.	"Riool M, de Breij A, Kwakman PHS, Schonkeren-Ravensbergen E, de Boer L, Cordfunke RA, Malanovic N, Drijfhout JW, Nibbering PH, Zaat SAJ."	Thrombocidin-1-derived antimicrobial peptide TC19 combats superficial multi-drug resistant bacterial wound infections 
DRAMP29057	RIVQRIKKWLLKWKKLGY	18	P5	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helical	Not found	None	Comment: This new peptide could be good candidates for future drug development for anti-biofilm and anti-infective therapy.	"[Ref.31778756] Gram-negative bacteria: P. aeruginosa (MIC = 64 ¦Ìg/mL, MBC = 128 ¦Ìg/mL); ##Gram-positive bacteria: S. aureus (MIC = 16 ?g/mL, MBC = 64 ¦Ìg/mL)"	[Ref.31778756]P5 displayed less than 10% hemolysis in all the range tested (0-1024 ¦Ìg/mL)	Linear 	Free	Free	None	L	Not found	Bacterial cytoplasmic membranes	31778756	Microb Pathog. 2020 Feb;139:103886. doi: 10.1016/j.micpath.2019.103886. Epub 2019 Nov 25.	"Mart¨ªnez M, Polizzotto A, Flores N, Semorile L, Maff¨ªa PC"	"Antibacterial, anti-biofilm and in vivo activities of the antimicrobial peptides P5 and P6.2 "
DRAMP29058	KGLLRKWGKKWKEFLRRVW	19	P6.2	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-"	Synthetic form	¦Á-helical	Not found	None	Comment: This new peptide could be good candidates for future drug development for anti-biofilm and anti-infective therapy.	"[Ref.31778756] Gram-negative bacteria: P. aeruginosa (MIC = 16 ¦Ìg/mL, MBC = 32 ¦Ìg/mL); ##Gram-positive bacteria: S. aureus (MIC = 32 ?g/mL, MBC = 128 ¦Ìg/mL)"	"[Ref.31778756]P6.2 exhibited a concentration dependent hemolytic activity, reaching values of 30% at the highest concentration(1024 ¦Ìg/mL), but remaining below 5% until 128 ¦Ìg/ml, which is fourfold or eightfold the MIC obtained for S.aureus or P.aeruginosa, respectively."	Linear 	Free	Free	None	L	Not found	Bacterial cytoplasmic membranes	31778756	Microb Pathog. 2020 Feb;139:103886. doi: 10.1016/j.micpath.2019.103886. Epub 2019 Nov 25.	"Mart¨ªnez M, Polizzotto A, Flores N, Semorile L, Maff¨ªa PC"	"Antibacterial, anti-biofilm and in vivo activities of the antimicrobial peptides P5 and P6.2 "
DRAMP29059	FLQRIIGALGRLF	13	temporin-GHaR	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	¦Á-helical	Not found	None	Comment: It showed potent antimicrobial activity with strong hemolytic toxicity	"[Ref.33291521] Gram-positive bacteria: S. aureus(MIC / MBC = 1.6¦ÌM / 1.6¦ÌM), B. subtilis(MIC / MBC = 12.5¦ÌM / 25¦ÌM), S. mutans(MIC / MBC = 3.1¦ÌM / 6.2¦ÌM), MRSA(MIC / MBC = 3.1¦ÌM / 3.1¦ÌM), MRSA-1(MIC /MBC = 3.1¦ÌM / 25¦ÌM), MRSA-2(MIC / MBC = 6.2¦ÌM / 12.5¦ÌM), MRSA-3(MIC / MBC = 3.1¦ÌM /6.2¦ÌM)##Gram-negative bacteria: E. coli(MIC / MBC = 6.2¦ÌM / 6.2¦ÌM),  D31(MIC /MBC = 12.5¦ÌM / 25¦ÌM), P. aeruginosa(MIC / MBC = 6.2¦ÌM / 6.2¦ÌM), PAO1(MIC / MBC = 25¦ÌM / 50¦ÌM)##Fungi: C. albicans(MIC / MBC = 12.5¦ÌM / 50¦ÌM)"	[Ref.33291521]HL50 = 48¦ÌM against human red blood cells (hRBCs)	Linear 	Free	Free	None	L	Not found	Cell membrane	33291521	Molecules. 2020 Dec 4;25(23):5724. doi: 10.3390/molecules25235724.	"Wei H, Xie Z, Tan X, Guo R, Song Y, Xie X, Wang R, Li L, Wang M, Zhang Y"	Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis 
DRAMP29060	FLQRIRGALGRLF	13	GHaR6R (variant of temporin-GHaR)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	¦Á-helical	Not found	None	"Comment: GHaR6R not only exerted antimicrobial activity by destroying cell membranes of planktonic bacteria, but also exhibited anti-biofilm activity.?The low-toxicity peptides of GHaR6R is expected to become promising antimicrobial candidate to develop anti-caries agents."	"[Ref.33291521] Gram-positive bacteria: S. aureus(MIC / MBC = 3.1¦ÌM / 12.5¦ÌM), B. subtilis(MIC / MBC = 25¦ÌM / 50¦ÌM), S. mutans(MIC / MBC = 12.5¦ÌM /  12.5¦ÌM), MRSA(MIC / MBC = 6.2¦ÌM / 12.5¦ÌM), MRSA-1(MIC /MBC = 12.5¦ÌM / 25¦ÌM), MRSA-2(MIC / MBC = 12.5¦ÌM / 25¦ÌM), MRSA-3(MIC / MBC = 6.2¦ÌM / 25¦ÌM)##Gram-negative bacteria: E. coli(MIC / MBC = 12.5¦ÌM / 12.5¦ÌM),  D31(MIC /MBC = 25¦ÌM / 50¦ÌM), P. aeruginosa(MIC / MBC > 50¦ÌM / 50¦ÌM), PAO1(MIC / MBC = 3.1¦ÌM / 25¦ÌM)##Fungi: C. albicans(MIC / MBC = 50¦ÌM / 50¦ÌM)"	[Ref.33291521]HL10 = 150¦ÌM against human red blood cells (hRBCs)	Linear 	Free	Free	None	L	"[Ref.33291521]GHaR6R induced a cell viability of 98%, 95% and 83% to human oral epithelial cells at 3.1¦ÌM, 6.2¦ÌM and 12.5¦ÌM."	Cell membrane	33291521	Molecules. 2020 Dec 4;25(23):5724. doi: 10.3390/molecules25235724.	"Wei H, Xie Z, Tan X, Guo R, Song Y, Xie X, Wang R, Li L, Wang M, Zhang Y"	Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis 
DRAMP29061	FLQRIIRALGRLF	13	GHaR7R (variant of temporin-GHaR)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	¦Á-helical	Not found	None	"Comment: GHaR6R not only exerted antimicrobial activity by destroying cell membranes of planktonic bacteria, but also exhibited anti-biofilm activity.?However, the hemolysis and cytotoxicity to HOECs of GHaR7R is too strong to make it not suitable be a good antimicrobial candidate"	"[Ref.33291521] Gram-positive bacteria: S. aureus(MIC / MBC = 3.1¦ÌM / 3.1¦ÌM), B. subtilis(MIC / MBC > 50¦ÌM / 50¦ÌM), S. mutans(MIC / MBC = 6.2¦ÌM /  12.5¦ÌM), MRSA(MIC / MBC = 3.1¦ÌM / 6.2¦ÌM), MRSA-1(MIC /MBC = 6.2¦ÌM / 25¦ÌM), MRSA-2(MIC / MBC = 6.2¦ÌM / 50¦ÌM), MRSA-3(MIC / MBC = 6.2¦ÌM / 25¦ÌM)##Gram-negative bacteria: E. coli(MIC / MBC = 3.1¦ÌM / 12.5¦ÌM),  D31(MIC /MBC = 12.5¦ÌM / 50¦ÌM), P. aeruginosa(MIC / MBC > 50¦ÌM / 50¦ÌM), PAO1(MIC / MBC > 50¦ÌM / 50¦ÌM)##Fungi: C. albicans(MIC / MBC = 25¦ÌM / 25¦ÌM)"	[Ref.33291521]HL50 = 10¦ÌM against human red blood cells (hRBCs)	Linear 	Free	Free	None	L	"[Ref.33291521]GHaR6R induced a cell viability of 62%, 50% and 39% to human oral epithelial cells at 3.1¦ÌM, 6.2¦ÌM and 12.5¦ÌM."	Cell membrane	33291521	Molecules. 2020 Dec 4;25(23):5724. doi: 10.3390/molecules25235724.	"Wei H, Xie Z, Tan X, Guo R, Song Y, Xie X, Wang R, Li L, Wang M, Zhang Y"	Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis 
DRAMP29062	FLQRIIGRLGRLF	13	GHaR8R (variant of temporin-GHaR)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	¦Á-helical	Not found	None	"Comment: GHaR6R not only exerted antimicrobial activity by destroying cell membranes of planktonic bacteria, but also exhibited anti-biofilm activity.?The low-toxicity peptides of GHaR6R is expected to become promising antimicrobial candidate to develop anti-caries agents."	"[Ref.33291521] Gram-positive bacteria: S. aureus(MIC / MBC = 1.6-3.1¦ÌM / 3.1¦ÌM), B. subtilis(MIC / MBC = 12.5¦ÌM / 12.5¦ÌM), S. mutans(MIC / MBC = 6.2¦ÌM /  6.2¦ÌM), MRSA(MIC / MBC = 3.1¦ÌM / 3.1¦ÌM), MRSA-1(MIC /MBC = 6.2¦ÌM / 6.2¦ÌM), MRSA-2(MIC / MBC = 3.1¦ÌM / 12.5¦ÌM), MRSA-3(MIC / MBC = 6.2¦ÌM / 12.5¦ÌM)##Gram-negative bacteria: E. coli(MIC / MBC = 3.1¦ÌM / 3.1¦ÌM),  D31(MIC /MBC = 12.5¦ÌM / 25¦ÌM), P. aeruginosa(MIC / MBC > 50¦ÌM / 50¦ÌM), PAO1(MIC / MBC = 6.2¦ÌM / 12.5¦ÌM)##Fungi: C. albicans(MIC / MBC = 12.5¦ÌM / 12.5¦ÌM)"	[Ref.33291521]HL50 = 160¦ÌM against human red blood cells (hRBCs)	Linear 	Free	Free	None	L	"[Ref.33291521]GHaR6R induced a cell viability of 83%, 64% and 50% to human oral epithelial cells at 3.1¦ÌM, 6.2¦ÌM and 12.5¦ÌM."	Cell membrane	33291521	Molecules. 2020 Dec 4;25(23):5724. doi: 10.3390/molecules25235724.	"Wei H, Xie Z, Tan X, Guo R, Song Y, Xie X, Wang R, Li L, Wang M, Zhang Y"	Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis 
DRAMP29064	FLQRIIGAWGRLL	13	GHaR9W (variant of temporin-GHaR)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	¦Á-helical	Not found	None	"Comment: GHaR6R not only exerted antimicrobial activity by destroying cell membranes of planktonic bacteria, but also exhibited anti-biofilm activity.?The low-toxicity peptides of GHaR6R is expected to become promising antimicrobial candidate to develop anti-caries agents."	"[Ref.33291521] Gram-positive bacteria: S. aureus(MIC / MBC = 3.1¦ÌM / 6.2¦ÌM), B. subtilis(MIC / MBC = 12.5¦ÌM / 50¦ÌM), S. mutans(MIC / MBC = 6.2¦ÌM /  6.2¦ÌM), MRSA(MIC / MBC = 6.2¦ÌM / 12.5¦ÌM), MRSA-1(MIC / MBC = 6.2¦ÌM / 12.5¦ÌM), MRSA-2(MIC / MBC = 6.2¦ÌM / 12.5¦ÌM), MRSA-3(MIC / MBC = 6.2¦ÌM / 12.5¦ÌM)##Gram-negative bacteria: E. coli(MIC / MBC = 12.5¦ÌM / 12.5¦ÌM),  D31(MIC /MBC = 12.5¦ÌM / 50¦ÌM), P. aeruginosa(MIC / MBC > 50¦ÌM / 50¦ÌM), PAO1(MIC / MBC = 25¦ÌM / 50¦ÌM)##Fungi: C. albicans(MIC / MBC = 25¦ÌM / 25¦ÌM)"	[Ref.33291521]HL50 = 90¦ÌM against human red blood cells (hRBCs)	Linear 	Free	Free	None	L	"[Ref.33291521]GHaR6R induced a cell viability of 74%, 63% and 60% to human oral epithelial cells at 3.1¦ÌM, 6.2¦ÌM and 12.5¦ÌM."	Cell membrane	33291521	Molecules. 2020 Dec 4;25(23):5724. doi: 10.3390/molecules25235724.	"Wei H, Xie Z, Tan X, Guo R, Song Y, Xie X, Wang R, Li L, Wang M, Zhang Y"	Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis 
DRAMP29065	KTMMQSGGTFGTFMAIGMGIR	21	AMPR-11(derived from Romo1)	P60602	Belongs to the?MGR2 family.	ROMO1	Homo sapiens (Human)	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Protein level	¦Á-helical	"AMPR-11 formed a random coil structure in distilled water but formed an ordered conformation in 50% hexafluoro-2-propanol (HFIP), which has been used for implementing a membrane-mimic environment "	None	"Comment: AMP derived from Romo1 (AMPR-11) is a promising agent for treatment of sepsis caused by MDR bacteria, and AMPR-11 could be combined with other potential antibiotics for clinical treatment."	"[Ref.33291307] Gram-positive bacteria: S. aureus(MBC=100 ¦Ìg/mL), B. subtilis(MBC=90 ¦Ìg/mL), E. faecium(MBC=85 ¦Ìg/mL), S. sindenensis(MBC=95 ¦Ìg/mL), E. faecalis(MBC=85 ¦Ìg/mL), S. pneumoniae(MBC=100 ¦Ìg/mL)##Gram-negative bacteria: E. coli(MBC=85 ¦Ìg/mL), P. aeruginosa(MBC=100 ¦Ìg/mL), K. pneumoniae(MBC=100 ¦Ìg/mL), A.?baumannii(MBC=100 ¦Ìg/mL), E. aerogenes(MBC=90 ¦Ìg/mL)##Multi-drug resistant bacteria: Methicillin-resistant S. aureus(MBC=100 ¦Ìg/mL), Carbapenem-resistant P. aeruginosa(MBC=110 ¦Ìg/mL), Carbapenem-resistant A.?baumannii(MBC=110 ¦Ìg/mL), Carbapenem-resistant K. pneumoniae(MBC=100 ¦Ìg/mL), Vancomycin-resistant S. aureus(MBC=120 ¦Ìg/mL), Vancomycin-resistant E. faecium(MBC=100 ¦Ìg/mL )"	"[Ref.33291307]At the concentration of 32 ¦Ìg/mL, AMPR-11 induced a hemolysis of 20% on mouse red blood cells; At the concentration of 256 ¦Ìg/mL, AMPR-11 induced a hemolysis of 23%."	Linear 	Free	Free	None	L	"[Ref.33291307] ¢ÙThe cell viability of HeLa cells was 90%, 87%, 83% and 79% at the concentration of 32, 64, 128 and 256 ¦Ìg/mL. ¢ÚThe cell viability of HEK293 cells was 86%, 83%, 80% and 78% at the concentration of 32, 64, 128 and 256 ¦Ìg/mL. ¢ÛThe cell viability of HeLa cells was 89%, 86%, 83% and 80% at the concentration of 32, 64, 128 and 256 ¦Ìg/mL. "	Bacterial membrane	32291307	mBio. 2020 Apr 14;11(2):e03258-19. doi: 10.1128/mBio.03258-19.	"Lee HR, You DG, Kim HK, Sohn JW, Kim MJ, Park JK, Lee GY, Yoo YD"	Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent against Multidrug-Resistant Bacteria in a Murine Model of Sepsis 
DRAMP29066	GFAWNVCVYRNGVRVCHRRAN	21	Marine peptide-N6	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	"¦Â-turn, coil and antiparallel sheet"	"¢ÙThe structure analysis showed that N6  have one rigid disulfide bridge Cys7-Cys16, which links the two ¦Â-strands (Cys3-Asn10 and Arg13-Cys20) and forms an anti-parallel ¦Â-sheet. ¢ÚThe secondary structures of N6NH2 and N6 in ddH2O were characterized by a coil and antiparallel strand or ¦Â-turn with a negative minimum at 200 nm. N6NH2 showed a more significant increase in ¦Á-helix and antiparallel strand in SDS solution than N6. Similarly, the CD spectrum of N6 and N6NH2 in 50% TFE showed one negative dichroic band at approximately 205 nm, and the positive maximum at 180 nm (strong) and at 230 nm "	5Y0H	Comment: N6NH2 and N6 are different from common antimicrobial peptides in the secondary structure. N6 has good antimicrobial activity.	"[Ref.33348729] Gram-negative bacteria: Edwardsiella tarda(MIC = 6.4 ¦Ìg/mL), Aeromonas veronii(MIC = 6.4 ¦Ìg/mL), Escherichia coli CVCC195(MIC = 0.5 ¦Ìg/mL), E. coli CVCC1515(MIC = 1 ¦Ìg/mL), E. coli CVCC25922(MIC = 0.25 ¦Ìg/mL), E. coli CVCCO157(MIC = 0.5 ¦Ìg/mL), Salmonella typhimurium CVCC533(MIC = 1 ¦Ìg/mL), S. typhimurium ATCC14028(MIC = 2 ¦Ìg/mL), S. enteritidis CVCC3377(MIC = 0.25 ¦Ìg/mL), S. pullorum CVCC1802(MIC = 0.5 ¦Ìg/mL), S. pullorum CVCC1789(MIC = 0.5 ¦Ìg/mL), Pseudomonas aeruginosa CICC21630(MIC = 4 ¦Ìg/mL). ##Gram-positive bacteria: Staphylococcus aureus ATCC43300(MIC = 16 ¦Ìg/mL), S. aureus ATCC546(MIC = 4 ¦Ìg/mL), S. aureus ATCC25923(MIC = 0.25 ¦Ìg/mL), S. hyicus 437-2(MIC = 64 ¦Ìg/mL), S. hyicus 15095(MIC = 16 ¦Ìg/mL)."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic 	Free	Free	There is a disulfide bond between Cys7 and Cys16	L	[Ref.33348729]Had very low cytotoxicity to mouse peritoneal RAW 264.7 macrophages (cell survival rate >93.35%)	Lipopolysaccharide (LPS) and genomic DNA	33348729	Mar Drugs. 2020 Dec 17;18(12):650. doi: 10.3390/md18120650.	"Han H, Li T, Wang Z, Teng D, Mao R, Hao Y, Yang N, Wang X, Wang J."	Improved Stability and Activity of a Marine Peptide-N6NH2 against Edwardsiella tarda and Its Preliminary Application in Fish 
DRAMP29067	GFAWNVCVYRNGVRVCHRRAN	21	N6NH2 (N6 amidated at its C-terminus)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	"¦Â-turn, coil and antiparallel sheet"	"¢ÙThe structure analysis showed that N6  have one rigid disulfide bridge Cys7-Cys16, which links the two ¦Â-strands (Cys3-Asn10 and Arg13-Cys20) and forms an anti-parallel ¦Â-sheet. ¢ÚThe secondary structures of N6NH2 and N6 in ddH2O were characterized by a coil and antiparallel strand or ¦Â-turn with a negative minimum at 200 nm. N6NH2 showed a more significant increase in ¦Á-helix and antiparallel strand in SDS solution than N6. Similarly, the CD spectrum of N6 and N6NH2 in 50% TFE showed one negative dichroic band at approximately 205 nm, and the positive maximum at 180 nm (strong) and at 230 nm "	5Y0H	"Comment: In the model of fish peritonitis caused by E. tarda, superior to norfloxacin, N6NH2 improved the survival rate of fish, reduced the bacterial load on the organs, alleviated the organ injury and regulated the immunity of the liver and kidney. Amidation of the C-termini seems to be important in improving the lytic activity of the peptides against pathogenic bacteria. N6NH2 and N6 are different from common antimicrobial peptides in the secondary structure."	"[Ref.33348729] Gram-negative bacteria: Edwardsiella tarda(MIC = 0.5 ¦Ìg/mL), Aeromonas veronii(MIC = 2 ¦Ìg/mL), Escherichia coli CVCC195(MIC = 0.06 ¦Ìg/mL), E. coli CVCC1515(MIC = 0.06 ¦Ìg/mL), E. coli CVCC25922(MIC = 0.06 ¦Ìg/mL), E. coli CVCCO157(MIC = 0.06 ¦Ìg/mL), Salmonella typhimurium CVCC533(MIC = 0.25 ¦Ìg/mL), S. typhimurium ATCC14028(MIC = 0.06 ¦Ìg/mL), S. enteritidis CVCC3377(MIC = 0.06 ¦Ìg/mL), S. pullorum CVCC1802(MIC = 0.25 ¦Ìg/mL), S. pullorum CVCC1789(MIC = 0.06 ¦Ìg/mL), Pseudomonas aeruginosa CICC21630(MIC = 0.06 ¦Ìg/mL). ##Gram-positive bacteria: Staphylococcus aureus ATCC43300(MIC = 1 ¦Ìg/mL), S. aureus ATCC546(MIC = 1 ¦Ìg/mL), S. aureus ATCC25923(MIC = 1 ¦Ìg/mL), S. hyicus 437-2(MIC = 16 ¦Ìg/mL), S. hyicus 15095 (MIC = 4 ¦Ìg/mL)."	"[Ref.33348729]The hemolysis of N6NH2 towards mouse erythrocytes was 0.19% at a concentration of 256 ¦Ìg/mL, lower than that of N6 (1.9%), indicating their low hemolytic activity "	Cyclic 	Free	Amidation	There is a disulfide bond between Cys7 and Cys16	L	[Ref.33348729]Had very low cytotoxicity to mouse peritoneal RAW 264.7 macrophages (cell survival rate >93.35%)	Lipopolysaccharide (LPS) and genomic DNA	33348729	Mar Drugs. 2020 Dec 17;18(12):650. doi: 10.3390/md18120650.	"Han H, Li T, Wang Z, Teng D, Mao R, Hao Y, Yang N, Wang X, Wang J."	Improved Stability and Activity of a Marine Peptide-N6NH2 against Edwardsiella tarda and Its Preliminary Application in Fish 
DRAMP29073	RIVELTLPRVSVRL	14	CF-14	No entry found	Not found	N/A	Catfish skin mucus	"Antimicrobial, Antibacterial, Anti-Gram-"	Protein level	It formed ¦Á-helix in PBS with 2.5% SDS but exhibited low ¦Á-content in PBS only.	"The CD spectra exhibited low ¦Á-helical content in PBS only. However, in PBS with 2.5% SDS, the CD spectra for CF-14 showed double-negative bands at 208?nm and 222?nm, indicating that CF-14 formed an ¦Á-helical structure under membrane-mimetic conditions."	None	"Comment: These results strongly indicated that CF-14 could be a potential novel antibiotic agent against E.coli. Hence, understanding the antibacterial mechanism and analyzing the amino acid sequence of CF-14 can aid in designing effective antimicrobial agents."	[Ref.32205189] Gram-negative bacteria: E.coli (MIC = 31.3 ¦Ìg/mL); ##[Ref.31291603]Gram-positive bacteria: S. putrefaciens (MIC = 62.5 ¦Ìg/mL)	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	None	L	Not found	Bacterial DNA	32205189##31291603	Fish Shellfish Immunol. 2020 May;100:489-495. doi: 10.1016/j.fsi.2020.03.038. Epub 2020 Mar 20.##Fish Shellfish Immunol. 2019 Sep;92:881-888. doi: 10.1016/j.fsi.2019.07.015. Epub 2019 Jul 7.	"Li T, Liu Q, Chen H, Li J##Tingting Li, Quanwei Liu, Dangfeng Wang, Jianrong Li"	"Antibacterial activity and mechanism of the cell-penetrating peptide CF-14 on the gram-negative bacteria, Escherichia coli.##Characterization and antimicrobial mechanism of CF-14, a new antimicrobial peptide from the epidermal mucus of catfish"
DRAMP29074	KRFWQLVPLAIKIYRAWKRR	20	dCATH (duck cathelicidin)	A0A493U1S6	Not found	N/A	Anas platyrhynchos platyrhynchos (Northern mallard)	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Unknown	"Initially, four analog peptides were designed by truncating two, four, six, and eight amino acids at the N-terminal ends of dCATH peptide. dCATH and its truncated analogs could not adopt the amphipathic ¦Á-helical structure since the hydrophobic and charged residues were dispersed all around the molecule. "	None	Comment: The peptide induces potent antimicrobial activity.	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 8 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 8 ¦ÌM), B. subtilis KCTC 3068 (MIC = 8 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 16 ¦ÌM), MRSA CCARM 3090 (MIC = 16 ¦ÌM), MRSA CCARM 3095 (MIC = 8 ¦ÌM), VREF ATCC 51559(MIC = 16 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 8 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 16 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 4 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 16 ¦ÌM), MDRPA CCARM 2109 (MIC = 16 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 ¦ÌM), C. albicans KCTC 7121 (MIC = 16 ¦ÌM)."	[Ref.32698035] HC10 = 5.1 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Free	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40 and 80 ¦ÌM, the cell survival of dCATH against human bone marrow SH-SY5Y cells is 103%, 103%, 100%, 68%, 36%, 13% and 8%."	Not found	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29075	FWQLVPLAIKIYRAWKRR	18	dCATH 18 (modified from dCATH)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Unknown	"Initially, four analog peptides were designed by truncating two, four, six, and eight amino acids at the N-terminal ends of dCATH peptide. dCATH and its truncated analogs could not adopt the amphipathic ¦Á-helical structure since the hydrophobic and charged residues were dispersed all around the molecule. "	None	Comment: The peptide induces potent antimicrobial activity.	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 8 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 16 ¦ÌM), B. subtilis KCTC 3068 (MIC = 8 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 32 ¦ÌM), MRSA CCARM 3090 (MIC = 16 ¦ÌM), MRSA CCARM 3095 (MIC = 32 ¦ÌM), VREF ATCC 51559(MIC = 32 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 16 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 16 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 8 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 32 ¦ÌM), MDRPA CCARM 2109 (MIC = 32 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 16 ¦ÌM), C. albicans KCTC 7121 (MIC = 16 ¦ÌM)."	[Ref.32698035] HC10 = 1.3 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 18 against human bone marrow SH-SY5Y cells is 102%, 83%, 75%, 52%, 23%, 9%, 7%."	Not found	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29076	QLVPLAIKIYRAWKRR	16	dCATH 16 (modified from dCATH)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Unknown	"Initially, four analog peptides were designed by truncating two, four, six, and eight amino acids at the N-terminal ends of dCATH peptide. dCATH and its truncated analogs could not adopt the amphipathic ¦Á-helical structure since the hydrophobic and charged residues were dispersed all around the molecule. "	None	Comment: The peptide induces potent antimicrobial activity.	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 8 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 16 ¦ÌM), B. subtilis KCTC 3068 (MIC = 16 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 32 ¦ÌM), MRSA CCARM 3090 (MIC = 16 ¦ÌM), MRSA CCARM 3095 (MIC = 32 ¦ÌM), VREF ATCC 51559(MIC = 32 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 32 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 16 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 16 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 32 ¦ÌM), MDRPA CCARM 2109 (MIC = 32 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 ¦ÌM), C. albicans KCTC 7121 (MIC = 16 ¦ÌM)."	[Ref.32698035] HC10 = 180 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 16 against human bone marrow SH-SY5Y cells is 98%, 95%, 91%, 86%, 54%, 36%, 32%."	Not found	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29077	VPLAIKIYRAWKRR	14	dCATH 14 (modified from dCATH)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Unknown	"Initially, four analog peptides were designed by truncating two, four, six, and eight amino acids at the N-terminal ends of dCATH peptide. dCATH and its truncated analogs could not adopt the amphipathic ¦Á-helical structure since the hydrophobic and charged residues were dispersed all around the molecule. "	None	Comment: The peptide induces potent antimicrobial activity.	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 8 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 16 ¦ÌM), B. subtilis KCTC 3068 (MIC = 4 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 32 ¦ÌM), MRSA CCARM 3090 (MIC = 32 ¦ÌM), MRSA CCARM 3095 (MIC = 32 ¦ÌM), VREF ATCC 51559(MIC = 16 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 16 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 8 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 8 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 32  ¦ÌM), MDRPA CCARM 2109 (MIC = 32 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 16 ¦ÌM), C. albicans KCTC 7121 (MIC = 16 ¦ÌM)."	[Ref.32698035] HC10 > 256 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 14 against human bone marrow SH-SY5Y cells is 103%, 101%, 100%, 100%, 91%, 74%, 70%"	Not found	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29078	LAIKIYRAWKRR	12	dCATH 12 (modified from dCATH)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Random coil in buffer; 26.56% ¦Á-helix content in 50% TFE; 7.93% ¦Á-helix content in 30 mM SDS; 26.91% ¦Á-helix content in 0.1% LPS	Not found	None	Comment: Contribute to the design of short AMPs with bactericidal and immunomodulatory properties for combating bacterial infection and sepsis.	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 8 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 4 ¦ÌM), B. subtilis KCTC 3068 (MIC = 8 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 32 ¦ÌM), MRSA CCARM 3090 (MIC = 32 ¦ÌM), MRSA CCARM 3095 (MIC = 32 ¦ÌM), VREF ATCC 51559(MIC = 32 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 16 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 4 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 8 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 32 ¦ÌM), MDRPA CCARM 2109 (MIC = 16 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 ¦ÌM), C. albicans KCTC 7121 (MIC = 16 ¦ÌM)."	[Ref.32698035] HC10 > 256 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 12 against human bone marrow SH-SY5Y cells is 103%, 103%, 102%, 99%, 97%, 79%, 67%"	Not found	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29079	LAKKIYRAWKRR	12	dCATH 12-1 (modified from dCATH 12)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Random coil in buffer; 6.24% ¦Á-helix content in 50% TFE; 7.52% ¦Á-helix content in 30 mM SDS; 8.73% ¦Á-helix content in 0.1% LPS	Not found	None	Comment: dCATH12-1 displayed high antimicrobial activity with minimal cytotoxicity	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 4 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 8 ¦ÌM), B. subtilis KCTC 3068 (MIC = 8 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 32 ¦ÌM), MRSA CCARM 3090 (MIC = 16 ¦ÌM), MRSA CCARM 3095 (MIC = 16 ¦ÌM), VREF ATCC 51559(MIC = 16 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 8 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 4 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 4 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 32 ¦ÌM), MDRPA CCARM 2109 (MIC = 32 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 ¦ÌM), C. albicans KCTC 7121 (MIC = 8 ¦ÌM)."	[Ref.32698035] HC10 > 256 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 12-1 against human bone marrow SH-SY5Y cells is 102%, 102%, 100%, 96%, 96%, 78%, 69%."	Not found	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29080	LAKKIYRAWKRW	12	dCATH 12-2 (modified from dCATH 12)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Random coil in buffer; 22.78% ¦Á-helix content in 50% TFE; 8.04% ¦Á-helix content in 30 mM SDS; 29.50% ¦Á-helix content in 0.1% LPS	Not found	None	Comment: dCATH12-2 displayed high antimicrobial activity with minimal cytotoxicity	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 4 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 8 ¦ÌM), B. subtilis KCTC 3068 (MIC = 4 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 32 ¦ÌM), MRSA CCARM 3090 (MIC = 16 ¦ÌM), MRSA CCARM 3095 (MIC = 16 ¦ÌM), VREF ATCC 51559(MIC = 16 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 16 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 4 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 2 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 16 ¦ÌM), MDRPA CCARM 2109 (MIC = 32 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 ¦ÌM), C. albicans KCTC 7121 (MIC = 8 ¦ÌM)."	[Ref.32698035] HC10 > 256 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 12-2 against human bone marrow SH-SY5Y cells is 102%, 101%, 100%, 100%, 97%, 92%, 85%."	Not found	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29081	LAKKIYRKWKRW	12	dCATH 12-3 (modified from dCATH 12)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Random coil in buffer; 27.42% ¦Á-helix content in 50% TFE; 23.60% ¦Á-helix content in 30 mM SDS; 23.51% ¦Á-helix content in 0.1% LPS	Not found	None	Comment: dCATH12-3 displayed high antimicrobial activity with minimal cytotoxicity	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 4 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 4 ¦ÌM), B. subtilis KCTC 3068 (MIC = 4 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 16 ¦ÌM), MRSA CCARM 3090 (MIC = 16 ¦ÌM), MRSA CCARM 3095 (MIC = 8 ¦ÌM), VREF ATCC 51559(MIC = 8 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 8 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 4 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 2 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 16 ¦ÌM), MDRPA CCARM 2109 (MIC = 8 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 ¦ÌM), C. albicans KCTC 7121 (MIC = 8 ¦ÌM)."	[Ref.32698035] HC10 > 256 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 12-3 against human bone marrow SH-SY5Y cells is 102%, 100%, 100%, 97%, 95%, 95%, 84%."	Not found	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29082	LIKKIYRKWKRW	12	dCATH 12-4 (modified from dCATH 12)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Random coil in buffer; 41.28% ¦Á-helix content in 50% TFE; 36.63% ¦Á-helix content in 30 mM SDS; 42.87% ¦Á-helix content in 0.1% LPS	"Among the 12-meric analog AMPs, Trp rich dCATH 12¨C4 and dCATH 12-5 displayed high helicity in all membrane-mimetic environment with highest?¦Á-helical conformation observed (42.8% and 40.4% respectively) in 0.1% LPS"	None	"Comment: dCATH 12-4 demonstrated synergistic actions with various conventional antibiotics against antibiotic resistant pathogens, thus indicating their ability as promising adjuncts to combination therapy. "	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 4 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 4 ¦ÌM), B. subtilis KCTC 3068 (MIC = 2 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 16 ¦ÌM), MRSA CCARM 3090 (MIC = 8 ¦ÌM), MRSA CCARM 3095 (MIC = 8 ¦ÌM), VREF ATCC 51559(MIC = 8 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 8 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 2 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 2 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 8 ¦ÌM), MDRPA CCARM 2109 (MIC = 8 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 ¦ÌM), C. albicans KCTC 7121 (MIC = 4 ¦ÌM)."	[Ref.32698035] HC10 > 256 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 12-4 against human bone marrow SH-SY5Y cells is 102%, 102%, 100%, 100%, 100%, 91%, 83%."	Bacterial DNA	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29083	LWKKIYRKWKRW	12	dCATH 12-5 (modified from dCATH 12)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	Random coil in buffer; 38.39% ¦Á-helix content in 50% TFE; 29.75% ¦Á-helix content in 30 mM SDS; 40.40% ¦Á-helix content in 0.1% LPS	"Among the 12-meric analog AMPs, Trp rich dCATH 12¨C4 and dCATH 12-5 displayed high helicity in all membrane-mimetic environment with highest?¦Á-helical conformation observed (42.8% and 40.4% respectively) in 0.1% LPS"	None	"Comment: dCATH 12-5 demonstrated synergistic actions with various conventional antibiotics against antibiotic resistant pathogens, thus indicating their ability as promising adjuncts to combination therapy. "	"[Ref.32698035] Gram-positive bacteria: S. aureus KCTC 1621 (MIC = 2 ¦ÌM), S. epidermidis KCTC 1917 (MIC = 4 ¦ÌM), B. subtilis KCTC 3068 (MIC = 2 ¦ÌM);##Resistant Gram-positive bacteria: MRSA CCARM 3089 (MIC = 16 ¦ÌM), MRSA CCARM 3090 (MIC = 8 ¦ÌM), MRSA CCARM 3095 (MIC = 8 ¦ÌM), VREF ATCC 51559(MIC = 8 ¦ÌM);##Gram-negative bacteria: E. coli KCTC 1682 (MIC = 4 ¦ÌM), P. aeruginosa KCTC 1637(MIC = 2 ¦ÌM), S. typhimurium KCTC 1926 (MIC = 2 ¦ÌM);##Resistant Gram-negative bacteria: MDRPAd CCARM 2095 (MIC = 8 ¦ÌM), MDRPA CCARM 2109 (MIC = 4 ¦ÌM); ##Yeast: C. albicans KCTC 7965 (MIC = 8 ¦ÌM), C. albicans KCTC 7121 (MIC = 4 ¦ÌM)."	[Ref.32698035] HC10 > 256 ¦ÌM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs).	Linear 	Free	Amidation	None	L	"[Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40, 80 ¦ÌM, the cell survival of dCATH 12-5 against human bone marrow SH-SY5Y cells is 102%, 101%, 100%, 100%, 100%, 95%, 87%."	Bacterial DNA	32698035	Eur J Med Chem. 2020 Oct 15;204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.	"Kumar SD, Shin SY"	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization 
DRAMP29084	GVTFNALKGVAKTVAAQLLKTAR	23	Brevinin-GR23	No entry found	Not found	N/A	Hylarana guentheri	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+"	Synthetic form	¦Á-helical	Not found	None	"Comment: Although B-GR23 did not show a potent antimicrobial and antibiofilm activity, the outstanding characteristic is the low toxicity on human blood red cells, which makes it an ideal template peptide to derive more powerful antimicrobial peptides"	"[Ref.31549575] Gram-positive bacteria: Staphylococcus aureus (MIC = 16 ¦ÌM), Streptococcus mutans(MIC > 100 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC = 64 ¦ÌM), Pseudomonas aeruginosa(MIC > 100 ¦ÌM);##Yeast: Canidia albican (MIC > 100 ¦ÌM)"	"[Ref.31549575]B-GR23 induced a hemolysis of 0.13%, 0.23%, 0.38%, 0.75%, 0.83% and 1.60% on human blood red cells at the concentrations of 25, 50, 75, 100, 150 and 200 ¦ÌM."	Linear 	Free	Amidation	None	L	Not found	Cell membrane	31549575	Biosci Biotechnol Biochem. 2020 Jan;84(1):143-153. doi: 10.1080/09168451.2019.1670045. Epub 2019 Sep 24.	"Hengren Zhong, Zhipeng Xie, Shuxia Zhang, Hanqi Wei, Yanting Song, Yingxia Zhang, Manchuriga Wang"	Brevinin-GR23 from frog Hylarana guentheri with antimicrobial and antibiofilm activities against Staphylococcus aureus
DRAMP29085	GLVTDTLKGAAKTVAAELLRKAH	23	B-GH23-1 	No entry found	Not found	N/A	Hylarana guentheri	"Antimicrobial, Antibacterial, Anti-Gram-"	Synthetic form	Not found	Not found	None	Comment: B-GH23-1 had slight antibacterial activity on S.aureus	"[Ref.31549575] Gram-positive bacteria: Staphylococcus aureus (MIC = 32-64 ¦ÌM), Streptococcus mutans(MIC > 100 ¦ÌM);##Gram-negative bacteria: Escherichia coli (MIC > 100 ¦ÌM), Pseudomonas aeruginosa(MIC > 100 ¦ÌM);##Yeast: Canidia albican (MIC > 100 ¦ÌM)"	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	None	L	Not found	Cell membrane	31549575	Biosci Biotechnol Biochem. 2020 Jan;84(1):143-153. doi: 10.1080/09168451.2019.1670045. Epub 2019 Sep 24.	"Hengren Zhong, Zhipeng Xie, Shuxia Zhang, Hanqi Wei, Yanting Song, Yingxia Zhang, Manchuriga Wang"	Brevinin-GR23 from frog Hylarana guentheri with antimicrobial and antibiofilm activities against Staphylococcus aureus
DRAMP29087	VRLIVKVRIWRR	12	RiLK1	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal"	Synthetic form	Disordered structure in aqueous solution; ¦Â-sheet in the presence of SDS (3 mM)	"Without SDS: 1.2% ¦Á-helix, 47.3% ¦Â-sheet, 51.5% random; t = 0 h with SDS:  7.4% ¦Á-helix, 51.4% ¦Â-sheet, 41.3% random; t = 5 min with SDS:  4.4% ¦Á-helix, 53.4% ¦Â-sheet, 42.2% random; t = 30 min with SDS: 11% ¦Á-helix, 48.7% ¦Â-sheet, 40.3% random; t = 1 h with SDS: 9.8% ¦Á-helix, 51.1% ¦Â-sheet, 39.1% random; t = 5 h with SDS: 6.7% ¦Á-helix, 54% ¦Â-sheet, 39.3% random; t = 6 h with SDS: 8% ¦Á-helix, 52% ¦Â-sheet, 40.1% random; t = 24 h with SDS: 8.4% ¦Á-helix, 53.6% ¦Â-sheet, 38% random"	None	"Comment: RiLK1 exerted potent killing effects against the clinical isolate (MBC = 1.25 M), two-fold lower than those observed against the strain isolated from food products and those determined with the parental peptide 1018-K6 against ACSSuT strain, thus, suggesting that RiLK1 might have a high potential also in the medical field."	"[Ref.32971824] Gram-negative bacteria: E.coli (IC50 = 1.20 ¡À 0.10 ¦ÌM, MBC = 2.0 ¦ÌM), S. Typhimurium (IC50 = 1.30 ¡À 0.14	¦ÌM, MBC = 2.5 ¦ÌM);##Gram-positive bacteria: S. aureus (IC50 = 1.98 ¡À 0.25 ¦ÌM, MBC = 16.0 ¦ÌM), L. monocytogenes (IC50 = 0.46 ¡À 0.01 ¦ÌM, MBC = 2.0 ¦ÌM);##Fungi: C. albicans ATCC 14053, A. brasiliensis ATCC 9341. Susceptibility testing clearly showed that RiLK1 was very effective, being able to inhibit 100% growth of both fungi at 25 ¦ÌM concentration (MFC)."	No hemolysis information or data found in the reference(s) presented in this entry	Linear 	Free	Amidation	None	L	"[Ref.32971824] It was observed that the cell viability was recorded as 98%, 98.7%, and 98.9% at the concentrations of RiLK1 (10, 25, 50 ¦ÌM)"	Not found	32971824	Int J Mol Sci. 2020 Sep 22;21(18):6952. doi: 10.3390/ijms21186952.	"Agrillo B, Proroga YTR, Gogliettino M, Balestrieri M, Tat¨¨ R, Nicolais L, Palmieri G"	A Safe and Multitasking Antimicrobial Decapeptide: The Road from De Novo Design to Structural and Functional Characterization 
DRAMP29093	XTXXXfLXXT	10	polymyxin B (a mixture of polymyxin B1 to B4)	No entry found	Belongs to the Polymyxins family	N/A	Paenibacillus polymyxa	"Antimicrobial, Antibacterial, Anti-Gram-, Anti-inflammatory"	Natural peptide(s)	"Ordered (the structure can not be described as ¦Á-helix, ¦Â-sheet or random coil simply)"	"[Ref2] According to the NMR data, there are eight structures fall into several groups, represented by the three structures. The overall structure is quite flat, with the aromatic ring oriented over the leucine methyl groups, and with a kink between residues 1?3 in the linear part of the peptide. However, differences in the ring pucker are evident, and changes in the ring pucker also affect other parts of the molecule. The peptide is interconverting among three possibilities. Changes in the ring pucker among the structures involves flipping residues 4, 8, and 9 while holding residues 6, 7, and "	None	"Polymyxin B is an old antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. While it is useful for many Gram-negative infections, it is not useful Gram-positive infections. It can be give by injection into a vein, muscle, or cerebrospinal fluid or inhaled. Polymyxin antibiotics are relatively neurotoxic and nephrotoxic, so are usually used only as a last resort if modern antibiotics are ineffective or are contraindicated. "	"[Ref.16524407] Gram-negative bacteria: Acinetobacter spp. (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 = 2 ¦Ìg/mL), Aeromonas spp. (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 £¾ 8 ¦Ìg/mL), Alcaligenes spp. (MIC50 = 2 ¦Ìg/mL, MIC90 > 8 ¦Ìg/mL), Burkholderia cepacia (MIC50 > 8 ¦Ìg/mL, MIC90 > 8 ¦Ìg/mL), Pseudomonas aeruginosa (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 = 2 ¦Ìg/mL), Pseudomonas spp. (non-aeruginosa) (MIC50 ¡Ü 1¦Ìg/mL, MIC90 = 4 ¦Ìg/mL), Stenotrophomonas maltophilia (MIC50 = 1 ¦Ìg/mL, MIC90 = 8 ¦Ìg/mL), other non-enteric bacilli (MIC50 = 4 ¦Ìg/mL, MIC90 > 4 ¦Ìg/mL); ##Enterobacteriaceae: Citrobacter spp. (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 ¡Ü 1 ¦Ìg/mL), Enterobacter spp. (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 > 8 ¦Ìg/mL), Escherichia coli (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 ¡Ü 1 ¦Ìg/mL), Klebsiella spp. (MIC50 ¡Ü 1¦Ìg/mL, MIC90 ¡Ü 1¦Ìg/mL), indole-positive Proteus spp. etc. (MIC50 > 8 ¦Ìg/mL, MIC90 > 8 ¦Ìg/mL), Proteus mirabilis (MIC50 > 8 ¦Ìg/mL, MIC90 > 8 ¦Ìg/mL), Salmonella spp. (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 = 4 ¦Ìg/mL), Shigella spp. (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 ¡Ü 1 ¦Ìg/mL), Serratia spp. (MIC50 > 8 ¦Ìg/mL, MIC90 > 8 ¦Ìg/mL), other enteric bacilli (MIC50 ¡Ü 1 ¦Ìg/mL, MIC90 = 8 ¦Ìg/mL). ##NOTE: indole-positive Proteus spp. etc. includes Morganella morganii, Proteus spp., Proteus vulgaris, Providencia alcalifaciens, Providencia rettgeri, Providencia spp. and Providencia stuartii."	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	"[Ref.17878146] Acylation of fatty acid (6-methyloctanoic acid for polymyxin B1, 6-methylheptanoic acid for B2, octanoic acid for B3 and heptanoic acid for B4)"	[Ref.17878146] Thr10 linking to Dab5 forming a cycle.	"[Ref.17878146] ¢ÙThe X in position 1, 3, 4, 5, 8 and 9 is ¦Á,¦Ã-diaminobutyric acid (Dab). ¢ÚDab4 links to Thr10 by amidation."	[Ref.17878146] L (mixed with D-Phe7)	Not found	Cell membrane	17878146##16524407	J Antimicrob Chemother. 2007 Dec;60(6):1206-15. doi: 10.1093/jac/dkm357. Epub 2007 Sep 17. ##Clin Microbiol Infect. 2006 Apr;12(4):315-21. doi: 10.1111/j.1469-0691.2005.01351.x.	"Alexandre Prehn Zavascki, Luciano Zubaran Goldani, Jian Li, Roger L Nation ##A C Gales, R N Jones, H S Sader"	Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review.##Global assessment of the antimicrobial activity of polymyxin B against 54 731 clinical isolates of Gram-negative bacilli: report from the SENTRY antimicrobial surveillance programme (2001-2004).
DRAMP29092	FKRLKKLISWIKRKRQQ	17	Hn-Mc (a chimeric peptide comprised of the N-terminus of HPA3NT3 and the C-terminus of melittin)	No entry found	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Anti-inflammatory"	Synthetic construct	Random coil or ¦Á-helical structure	"Hn-Mc adopted a random coil structure in the SUVs containing a mammalian membrane and in the buffer; however, it adopted an ¦Á-helical structure in SUVs containing a fungal membrane, indicating that it was not bound to the mammalian membrane but rather adhered to or inserted in the fungal membrane.?"	None	"Comment: Hn-Mc has a high affinity for the fungal plasma membrane and induces apoptosis in fungal cells, and provide guidance for the development of new antifungal agents. Hn-Mc is an excellent model peptide with potent antibacterial activity and non-cytotoxicity."	"[Ref.32731574]Yeast: C. albicans (MIC = 16 ¦ÌM), C. krusei (MIC = 8 ¦ÌM), C. parapsilosis (MIC = 16 ¦ÌM), C. tropicalis (MIC = 4 ¦ÌM), T. beigellii (MIC = 1 ¦ÌM);##Mold: T. rubrum (MIC = 1-2 ¦ÌM), F. moniliforme(MIC = 1-2 ¦ÌM), F. solani(MIC = 1 ¦ÌM), F. oxysporum(MIC = 1-2 ¦ÌM), A. flavus(MIC = 2-4 ¦ÌM), A. fumigatus(MIC = 2-4 ¦ÌM). ##[Ref.26028561] Drug-susceptible gram-negative bacteria: E. coli (MIC = 1 ¦ÌM), P. aeruginosa (MIC = 2 ¦ÌM); ##Drug-susceptible gram-positive bacteria: S. aureus (MIC = 2 ¦ÌM), B. subtilis(MIC = 2 ¦ÌM);##Drug-resistant bacteria:  P. aeruginosa DRPA-001 (MIC = 1 ¦ÌM),  P. aeruginosa DRPA-002 (MIC = 1 ¦ÌM),  P. aeruginosa DRPA-003 (MIC = 1 ¦ÌM),  P. aeruginosa DRPA-004 (MIC = 1 ¦ÌM),  P. aeruginosa DRPA-005 (MIC = 2 ¦ÌM), S. aureus DRSA-001 (MIC = 2 ¦ÌM), S. aureus DRSA-002 (MIC = 2 ¦ÌM), S. aureus DRSA-003 (MIC = 1 ¦ÌM), S. aureus DRSA-004 (MIC = 2 ¦ÌM), S. aureus DRSA-005 (MIC = 2 ¦ÌM)."	"[Ref.26028561] HPA3NT3 and melittin revealed the hemolysis of 68.2% and 100% at 250 ¦ÌM, respectively, but Hn-Mc was 1.1% at the same concentration"	Linear 	Free	Amidation	None	L	"[Ref.26028561] The IC50 of HPA3NT3, melittin and Hn-Mc against HaCaT cells were 49.5, 2.8 and 357.5 ¦ÌM, respectively"	Mitochondria (possibily)	32731574##26028561	Antibiotics (Basel). 2020 Jul 28;9(8):454. doi: 10.3390/antibiotics9080454.##Biochem Biophys Res Commun. 2015 Jul 31;463(3):322-8. doi: 10.1016/j.bbrc.2015.05.063. Epub 2015 May 29.	"Kim JY, Park SC, Noh G, Kim H, Yoo SH, Kim IR, Lee JR, Jang MK.##Young-Min Kim, Nam-Hong Kim, Jong-Wan Lee, Jin-Sun Jang, Yung-Hoon Park, Seong-Cheol Park, Mi-Kyeong Jang"	Antifungal Effect of A Chimeric Peptide Hn-Mc against Pathogenic Fungal Strains. ##Novel chimeric peptide with enhanced cell specificity and anti-inflammatory activity.
DRAMP29094	GPKTKAACKMACKLATCGKKPGGWKCKLCELGCDAV	36	Turgencin A	C0HLN5	Not found	N/A	Synoicum turgens	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-,Anti-cancer"	Protein level	Random coil	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.32751755]Gram-positive bacteria:Bacillus megaterium(MIC=0.5 ?g/mL); Bacillus subtilis(MIC=1.5 ?g/mL); Corynebacterium glutamicum(MIC=1.5 ?g/mL); Micrococcus luteus(MIC=8.0 ?g/mL); Staphylococcus aureus(MIC=23.3 ?g/mL);##Gram-negative bacteria:Escherichia coli(MIC=3.0 ?g/mL); Pseudomonas aeruginosa(MIC=5.9 ?g/mL);##Fungi: Rhodotorula sp(MIC=23.2 ?g/mL);Aurobasidium pollulans(MIC=92.6 ?g/mL); Candida albicans(MIC=46.3 ?g/mL).##[Ref.31940927]Cancer:Human melanoma A2058(IC50=1.4 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Amidation	"Disulfide bond between Cys8 and Cys33, Cys12 and Cys29, Cys17 and Cys26; the 'Met' at position 10 is Methionine sulfoxide."	L	[Ref.31940927]Cytotoxicity: Human fibroblasts MRC-5(IC50=4.8 ¦ÌM).	liposomes	32751755##31940927	Int J Mol Sci.2020 Jul 30;21(15):5460.##Mar Drugs. 2020 Jan 12;18(1):51.	"Hansen IK?, L?vdahl T, Simonovic D, Hansen K?, Andersen AJC, Devold H, Richard CSM, Andersen JH, Str?m MB, Haug T.##Hansen IK?, Isaksson J, Poth AG, Hansen K?, Andersen AJC, Richard CSM, Blencke HM, Stensv?g K, Craik DJ, Haug T. "	Antimicrobial Activity of Small Synthetic Peptides Based on the Marine Peptide Turgencin A: Prediction of Antimicrobial Peptide Sequences in a Natural Peptide and Strategy for Optimization of Potency.##Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens.
DRAMP29095	GIKEMLCNMACAQTVCKKSGGPLCDTCQAACKALG	35	Turgencin B	C0HLN6	Not found	N/A	Synoicum turgens	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-,Anti-cancer"	Protein level	"Alpha helix,random coil"	Not found	None	Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.31940927]Gram-positive bacteria:Corynebacterium glutamicum ATCC 13032(MIC=1.6 ?M);Bacillus subtilis ATCC 23857(MIC=1.6 ?M);Staphylococcus aureus ATCC 9144(MIC>100?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=12.5 ?M);Pseudomonas aeruginosa ATCC 27853(MIC=25.0 ?M);##Cancer:Human melanoma A2058(IC50=4.1 ¦ÌM).	No hemolysis information or data found in the reference(s) presented in this entry	Cyclic	Free	Amidation	"Disulfide bond between Cys7 and Cys31, Cys11 and Cys27, Cys16 and Cys24; the 'Met' at position 5 and 9 is Methionine sulfoxide."	L	[Ref.31940927]Cytotoxicity: Human fibroblasts MRC-5(IC50=7.5 ¦ÌM).	liposomes	31940927	Mar Drugs. 2020 Jan 12;18(1):51.	"Hansen IK?, Isaksson J, Poth AG, Hansen K?, Andersen AJC, Richard CSM, Blencke HM, Stensv?g K, Craik DJ, Haug T. "	
DRAMP29096	GLPGPLGPAGPK	12	Collagencin	"S4R4C8,	S4R4C7,	S4R4C5"	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Predicted	"Alpha helix,beta sheet,beta turn,random coil"	"The deconvolution of CD spectra in PBS buffer revealed that collagencin structure was organized as follow: 5.5% of ¦Á-helix, 19.3% of ¦Â-sheet, 36.3% of ¦Â-turn and 38.9% unordered. In methanol(organic buffers), a shift between ¦Â-sheet (36.4%) and ¦Â-turn (22.1%) was observed in collagencin structure while helix (4.9%) and unordered structure (36.6%) contents remained stables.In presence of DPPG phospholipids, a shift between ¦Â-sheet and ¦Â-turn was observed in collagencin structure. A maximal ¦Â-sheet content (49.7%) was observed at highest lipid: peptide ratio (100:1). In presence of POPG, ¦Á-helix"	None	"Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Collagencin highly interacts with both anionic and zwitterionic phospholipids but remains at membrane¨Cwater interface, which suggests a carpet mechanism of action of the peptide. Collagencin is probably antihypertensive according to its high similarity to peptide PGPLGLTGP, an ACE inhibitor that was previously isolated from skate skin hydrolysate."	[Ref.27038545]32.2% growth inhibition on Listeria innocua HPB29 at 235 ?M; 31% growth inhibition on Lactococcus lactis ATCC 11454 at 235 ?M ; 32.2% growth inhibition on Carnobacterium divergens M35 at 235 ?M; 67% growth inhibition on Staphylococcus aureus ATCC 6538 at 235 ?M; 62% growth inhibition on Streptococcus pyogenes ATCC19615 at 235 ?M; 64% growth inhibition on Escherichia coli MC4100 at 235 ?M; Escherichia coli O157:H7(NA); Aeromonas hydrophila ATCC 7966(NA); Pseudomonas aeruginosa ATCC 27853(NA).	[Ref.27038545]non-toxic to horse erythrocytes up to 470 ¦ÌM; 25% hemolysis against horse erythrocytes at 940 ?M.	Linear	Free	Free	None	L	[Ref.27038545]No cytotoxicity information found.	liposomes	27038545	Biochem Biophys Res Commun. 2016 Apr 29;473(2):642-7. 	"Ennaas N, Hammami R, Gomaa A, B¨¦dard F, Biron ?, Subirade M, Beaulieu L, Fliss I."	"Collagencin, an antibacterial peptide from fish collagen: Activity, structure and interaction dynamics with membrane."
DRAMP29097	TQQAFQKFLAAVTSALGKQYH	21	SH¦ÂAP	No entry found	Not found	Not found	Katsuwonus pelamis	"Antimicrobial, Antibacterial,Anti-Gram+,Anti-Gram-,Antifungal"	Not found	Alpha helix	Not found	None	Function:SH¦ÂAP showed broad spectrum antimicrobial activity without hemolytic activity.Antimicrobial activity of the peptide was heatstable and pH resistant but is sensitive to proteases and salt.The action mode of SH¦ÂAP is bacteriostatic process rather than bactericidal one.	[Ref.24495783]Gram-positive bacteria:B.subtilis KCTC1021(MEC=16.0 ¦Ìg/mL); B.subtilis RM125(MEC=6.5 ¦Ìg/mL); S.aureus KCTC1621(MEC=57.0 ¦Ìg/mL);S.iniae FP5229(MEC=23.0 ¦Ìg/mL);##Gram-negative bacteria:E.coli D31(MEC=15.0 ¦Ìg/mL); E.coli KCTC1116(MEC=2.6 ¦Ìg/mL); E.coli ML35p(MEC=6.2 ¦Ìg/mL); P.aeruginosa KCTC2004(MEC=19.0 ¦Ìg/mL); S.enterica KCTC2514(MEC=2.0 ¦Ìg/mL); S.sonnei KCTC2009(MEC=6.0 ¦Ìg/mL);A.hydrophila KCTC2358(MEC>125.0 ¦Ìg/mL); V.parahaemolyticus HUFP91(MEC=1.9 ¦Ìg/mL); V.parahaemolyticus KCCM41664(MEC=1.5 ¦Ìg/mL);##Yeast:C.albicans KCTC7965(MEC=12.0 ¦Ìg/mL).	[Ref.24495783]not cause hemolysis against RBCs up to 100 ¦Ìg/mL concentration.	Linear	Free	Free	None	L	[Ref.24495783]No cytotoxicity information found.	liposomes	24495783	Fish Shellfish Immunol. 2014 Mar;37(1):173-83. 	"Seo JK, Lee MJ, Jung HG, Go HJ, Kim YJ, Park NG. "	"Antimicrobial function of SH¦ÂAP, a novel hemoglobin ¦Â chain-related antimicrobial peptide, isolated from the liver of skipjack tuna, Katsuwonus pelamis."
DRAMP29098	GLSRLFTALK	10	ACWWP1	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Not found	Not found	Not found	None	Function:The change in cell surface hydrophobicity and membrane-permeable action of the purified ACWWP1 may have contributed to the antibacterial effect. 	[Ref.25172690]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=16 ?g/ml); Bacillus subtilis ATCC 9372(MIC=16 ?g/ml); Streptococcus pneumoniae ATCC 49619(MIC=64 ?g/ml);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=32 ?g/ml); Shigella dysenteriae ATCC 51302(MIC=256 ?g/ml); Pseudomonas aeruginosa ATCC 27853 (MIC=64 ?g/ml); Salmonella typhimurium ATCC 50013(MIC=32 ?g/ml).	[Ref.25172690]non-toxic to mouse erythrocytes up to 512 ?g/ml.	Linear	Free	Free	None	L	[Ref.25172690]No cytotoxicity information found.	liposomes	25172690	Food Chem. 2015 Feb 1;168:115-23.	"Tang W, Zhang H, Wang L, Qian H, Qi X."	Targeted separation of antibacterial peptide from protein hydrolysate of anchovy cooking wastewater by equilibrium dialysis.
DRAMP29099	GLRKRLRKFRNKIKEKLKKIGQKIQGLLPKLAPRTDY	37	CAP18	G1T9L4	Not found	camp	Oryctolagus cuniculus	"Antimicrobial, Antibacterial,Anti-Gram+,Anti-Gram-"	Homology	Alpha helix	The peptide adopted an appreciable ¦Á-helical content in the presence of the organic cosolvent 40% trifluoroethanol and in the presence of 0.1% lipopolysaccharide.	None	"Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.CAP18 were active against P. aeruginosa, E. coli, S. aureus, and MRSA."	"[Ref.11557478]Gram-negative bacteria:Pseudomonas aeruginosa(MIC=1-32 ?g/ml); Pseudomonas aeruginosa(MIC50=4 ?g/ml); Pseudomonas aeruginosa(MIC90=16 ?g/ml); Stenotrophomonas maltophilia(MIC=2-16 ?g/ml); Achromobacter xylosoxidans(MIC=2-32 ?g/ml).##[Ref.10768969]Gram-positive bacteria:Staphylococcus aureus ATCC 33591(MIC=1.24 ?M ); Staphylococcus aureus ATCC 33591(100 mM NaCl,MIC=1.36 ?M); Staphylococcus aureus 930918-3(MIC=0.41 ?M); Staphylococcus aureus 930918-3(100 mM NaCl,MIC=0.63 ?M);##Gram-negative bacteria:Pseudomonas aeruginosa PAO1(25 mM NaCl,EC50=0.22¡À0.05 ?M); Pseudomonas aeruginosa PAO1(175 mM NaCl, EC50=0.11¡À0.02 ?M); Escherichia coli DH5¦Á(MIC=0.19 ?M); Escherichia coli DH5¦Á(100 mM NaCl, MIC=0.21 ?M); Escherichia coli ML-35p(MIC=0.05 ?M); Escherichia coli ML-35p(100 mM NaCl, MIC=0.09 ?M); Pseudomonas aeruginosa PAO1(MIC=0.20 ?M); Pseudomonas aeruginosa PAO1(100 mM NaCl, MIC=0.62 ?M); Pseudomonas aeruginosa MR3007(MIC=0.05 ?M); Pseudomonas aeruginosa MR3007(100 mM NaCl, MIC=0.36 ?M).##[Ref.26656394]Gram-negative bacteria:Yersinia ruckeri 392/2003(MIC=2-4 ?g/ml); Aeromonas salmonicida ATCC 49385(MIC=2 ?g/ml); Salmonella enterica serovar Typhimurium LT2(MIC=4-8 ?g/ml); Campylobacter jejuni NCTC 11168(MIC=1 ?g/ml); Escherichia coli ATCC 25922(MIC=4-8 ?g/ml ); Pseudomonas aeruginosa ATCC 27853(MIC=4-8 ?g/ml); Escherichia coli BW25113(MIC=4-8 ?g/ml); Escherichia coli BW25113 del-rfaC(MIC=4 ?g/ml); Escherichia coli ATCC 25922 del-rfaC(MIC=2 ?g/ml);##Gram-positive bacterial:Flavobacterium psychrophilum 1947(MIC>>256 ?g/ml); Staphylococcus aureus ATCC 29213(MIC>=32 ?g/ml); Enterococcus faecalis ATCC 29212(MIC=8 ?g/ml); Listeria monocytogenes N22-2(MIC=2-4 ?g/ml).##[Ref.30245684]Gram-negative bacterial:Escherichia coli ATCC 25922 del-waaC(MIC=2-4 ?g/ml); Escherichia coli ATCC 25922 del-waaE(MIC=4 ?g/ml); Escherichia coli ATCC 25922 del-waaF(MIC=2-4 ?g/ml); Escherichia coli ATCC 25922 del-waaG(MIC=4 ?g/ml); Escherichia coli JW3596(MIC=4 ?g/ml); Escherichia coli JW1667(MIC=2-4 ?g/ml ).##[Ref.29852015]Gram-negative bacterial:Aeromonas salmonicida ATCC 33658(MIC=4 ?g/ml);##Gram-positive bacterial:Lactococcus lactis IL1403(MIC=1-2 ?g/ml)."	[Ref.10768969]non-hemolysis against Human erythrocytes up to 500 ?g/ml.##[Ref.26656394]1% hemolysis against Horse erythrocytes at 64 ?g/ml.	Linear	Free	Free	None	L	Not found	liposomes	11557478##10768969##26656394##30245684##29852015	Antimicrob Agents Chemother. 2001 Oct;45(10):2838-2844.##Infect Immun. 2000 May;68(5):2748-2755.##PLoS One. 2015 Dec 11;10(12):e0144611.##Front Microbiol. 2018 Sep 7;9:2153.##PLoS One. 2018 May 31;13(5):e0197742.	"Saiman L, Tabibi S, Starner TD, San Gabriel P, Winokur PL, Jia HP, McCray PB Jr, Tack BF.##Travis SM, Anderson NN, Forsyth WR, Espiritu C, Conway BD, Greenberg EP, McCray PB Jr, Lehrer RI, Welsh MJ, Tack BF.##Ebbensgaard A, Mordhorst H, Overgaard MT, Nielsen CG, Aarestrup FM, Hansen EB.##Ebbensgaard A, Mordhorst H, Aarestrup FM, Hansen EB.##Ebbensgaard A, Mordhorst H, Overgaard MT, Aarestrup FM, Hansen EB."	Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis.##Bactericidal activity of mammalian cathelicidin-derived peptides.##Comparative Evaluation of the Antimicrobial Activity of Different Antimicrobial Peptides against a Range of Pathogenic Bacteria.##The Role of Outer Membrane Proteins and Lipopolysaccharides for the Sensitivity of Escherichia coli to Antimicrobial Peptides. ##Dissection of the antimicrobial and hemolytic activity of Cap18: Generation of Cap18 derivatives with enhanced specificity.
DRAMP29100	GIRDVLKGAAKAFVKTVAGHIAN	23	Ascaphin-1 [F2I]	P0CJ25	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram-"	Protein level	Not found	Not found	None	Function:Antibacterial activity against Gram-positive bacteria	[Ref.19947578]Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=4 ?M).	[Ref.19947578]25% hemolysis against human erythrocytes at 100 ?M.	Linear	Free	Amidation	None	L	[Ref.19947578]No cytotoxicity information found.	liposomes	19947578	J Chem Inf Model. 2009 Dec;49(12):2873-82.	"Jureti? D, Vukicevi? D, Ili? N, Antcheva N, Tossi A."	Computational design of highly selective antimicrobial peptides.
DRAMP29101	GFKDLLKGAAKALVKAVLF	19	Ascaphin-8 [T16A]	P0CJ32	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer, Antifungal"	Protein level	Alpha helix	45% ¦Á-helix was determined from the circular dichroism spectra recorded in 50% trifluoroethanol-water.	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=6 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=3 ?M);##Fungi:Candida albicans ATCC 900280(MIC=6 ?M).##Cancer:human hepatoma©\derived cells HepG2 (LC50=9 ?M).	[Ref.18554256]Hemolysis against human erythrocytes (LC50=22 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]Cytotoxicity:Mouse fibroblasts L929 (LC50=5 ?M).	liposomes	18554256	Chem Biol Drug Des. 2008 Jul;72(1):58-64. 	"Conlon JM, Galadari S, Raza H, Condamine E."	"Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29102	KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL	30	Hc-CATH	No entry found	Not found	Not found	Hydrophis cyanocinctus	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer, Antifungal"	Not found	"Alpha helix,¦Â-sheet,random coil"	"The CD spectra in H2O adopts a random-coil conformation. In the membrane-mimetic environments of SDS/H2O solutions (30¨C120 mm), the secondary structure components of Hc-CATH dissolved in 60 mm SDS/H2O were calculated as 59.9% ¦Á-helix, 16% ¦Â-sheet, 0% ¦Â-turn, and 24% random coil.When dissolved in SDS/H2O solutions with serial concentrations of NaCl (at 0, 100, 200, and 400 mm), the ¦Á-helix contents decreased slightly from 59.9 to 33.8% as the NaCl concentration increased. Simultaneously, the contents of the ¦Â-turn (0 to 14.9%) and random coil (24 to 30.5%) increased slightly. "	None	"Function:The microbial killing activity of Hc-CATH is executed through the disruption of cell membrane and lysis of bacterial cells. Antimicrobial activity of Hc-CATH in the presence of a high concentration of sodium chlorideIn addition is strong. Hc-CATH exhibited potent anti-inflammatory activity by inhibiting the LPS-induced production of nitric oxide (NO) and pro-inflammatory cytokines such as TNF-¦Á, IL-1¦Â, and IL-6."	"[Ref.26013823]Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=2.34 ?g/ml); Escherichia coli ATCC 25922(400 Mm NaCl,MIC=4.69 ?g/ml); Escherichia coli 1(MIC=2.34 ?g/ml);Escherichia coli 2(MIC=2.34 ?g/ml); Escherichia coli 3(MIC=2.34 ?g/ml); Escherichia coli 4(MIC=9.38 ?g/ml); Shigella dysenteriae(MIC=0.59 ?g/ml); Klebsiella pneumoniae 1(MIC=37.50 ?g/ml); Klebsiella pneumoniae 2(MIC=4.69 ?g/ml); Klebsiella pneumoniae 3(MIC=9.38 ?g/ml); Klebsiella pneumoniae 4(MIC=9.38 ?g/ml); Klebsiella pneumoniae 5(MIC=18.75 ?g/ml); Klebsiella pneumoniae 6(MIC=37.50 ?g/ml); Klebsiella pneumoniae 7(MIC=37.50 ?g/ml); Klebsiella pneumoniae 8(MIC=75.00 ?g/ml); Serratia marcescens(MIC>200 ?g/ml); Klebsiella oxytoca(MIC=4.69 ?g/ml); Proteus vulgaris(MIC>200 ?g/ml); Proteus mirabilis(MIC=4.69 ?g/ml); Acinetobacter baumannii 1(MIC>200 ?g/ml); Acinetobacter baumannii 2(MIC>200 ?g/ml); Stenotrophomonas maltophilia(MIC>200 ?g/ml); Stenotrophomonas maltophilia 2(MIC=9.38 ?g/ml); Pseudomonas aeruginosa ATCC 27853(MIC=18.75 ?g/ml); Pseudomonas aeruginosa 1 (MIC=37.50 ?g/ml ); Pseudomonas aeruginosa(MIC>200 ?g/ml); Salmonella paratyphi A(MIC=4.69 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4.69 ?g/ml); Staphylococcus aureus 1(MIC>200 ?g/ml ); Staphylococcus aureus 2(MIC>200 ?g/ml ); Staphylococcus aureus 3(MIC>200 ?g/ml ); Staphylococcus aureus 4(MIC=4.69 ?g/ml); Staphylococcus aureus 5(MIC=4.69 ?g/ml); Bacillus cereus(MIC=9.38 ?g/ml); Bacillus subtilis(MIC=75.00 ?g/ml); Enterococcus faecium(MIC=37.50 ?g/ml); Nocardia asteroides(MIC=9.38 ?g/ml); Enterococcus faecalis(MIC>200 ?g/ml); Staphylococcus epidermidis(MIC>200 ?g/ml);##Fungi:Candida albicans 1(MIC=4.69 ?g/ml); Candida albicans 2(MIC=4.69 ?g/ml); Candida albicans 3(MIC=4.69 ?g/ml); Candida albicans 4(MIC=4.69 ?g/ml); Candida albicans 5(MIC=2.34 ?g/ml); Candida albicans 6(MIC=2.34 ?g/ml); Candida glabrata 1(MIC=2.34 ?g/ml); Candida glabrata(MIC>200 ?g/ml); Cryptococcus neoformans(MIC>200 ?g/ml); Arcyria cinerea(MIC=9.38 ?g/ml);##Pathogenic bacteria:Aeromonas sobria(MIC=2.34 ?g/ml); Aeromonas hydrophila(MIC=2.34 ?g/ml); Aeromonas veronii(MIC=2.34 ?g/ml); Vibrio vulnificus(MIC=4.69 ?g/ml ); Vibrio harveyi(MIC=9.38 ?g/ml); Vibrio fluvialis(MIC=4.69 ?g/ml); Vibrio alginolyticus(MIC=4.69 ?g/ml); Vibrio parahaemolyticus(MIC=9.38 ?g/ml); Vibrio splendidus(MIC=2.34 ?g/ml); Vibrio anguillarum(MIC=18.75 ?g/ml); Edwardsiella tarda(MIC=2.34 ?g/ml)."	[Ref.26013823]5.25% Hemolysis against Human erythrocytes at 200 ?g/ml(55.12 ¦ÌM).	Linear	Free	Free	None	L	[Ref.26013823]4.70% cell death at 200 ?g/ml against Human hepatocellular carcinoma HepG2; 3.63% cell death at 200 ?g/ml against Human prostate adenocarcinoma PC-3; 1.30% cell death at 200 ?g/ml against Mouse fibroblasts L929.	liposomes	26013823	J Biol Chem. 2015 Jul 3;290(27):16633-52.	"Wei L, Gao J, Zhang S, Wu S, Xie Z, Ling G, Kuang YQ, Yang Y, Yu H, Wang Y."	Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity and Special Mechanism.
DRAMP29103	KWKLFKKIHKVGQNIRKGIIKAGPAVAVVGQAAQIAK	37	PEW300	P01507	Not found	N/A	Synthetic construct(Mutation of cecropin-A)	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	Alpha helix(Predicted)	Not found	None	"Function:Purified PEW300 exhibited strong antibacterial activity against various Gram-positive and Gram-negative bacteria.PEW300 had no hemolytic activity toward mammalian cells even at high concentration (224 ng/¦Ìl).It showed good stability in neutral and alkaline solutions. PEW300 was thermally stable even at up to 100 ¡ãC and resistant to proteinase K, pepsin, snailase, and trypsin.The incubation with human serum had no effect on the antibacterial activity of PEW300."	[Ref.30607494]Gram-positive bacteria:Staphylococcus aureus ATCC 6538(MIC=14.18 ?g/ml); Staphylococcus aureus ATCC 6538(MBC=28.36 ?g/ml); Bacillus megaterium ATCC 14945(MIC=7.09 ?g/ml); Bacillus megaterium ATCC 14945(MBC=14.18 ?g/ml); Bacillus licheniformis ATCC 14580(MIC=14.18 ?g/ml); Bacillus licheniformis ATCC 14580(MBC=14.18 ?g/ml); Staphylococcus epidermidis ATCC 12228(MIC=7.09 ?g/ml); Staphylococcus epidermidis ATCC 12228(MBC=7.09 ?g/ml);Bacillus cereus ATCC 10876(MIC=14.18 ?g/ml);Bacillus cereus ATCC 10876(MBC=28.36 ?g/ml);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=7.09 ?g/ml); Escherichia coli ATCC 25922(MBC=7.09 ?g/ml); Pseudomonas aeruginosa ATCC 9027(MIC=14.18 ?g/ml); Pseudomonas aeruginosa ATCC 9027(MBC=14.18 ?g/ml); Stenotrophomonas maltophilia ATCC 51331(MIC=28.35 ?g/ml); Stenotrophomonas maltophilia ATCC 51331(MBC=56.70 ?g/ml); Pseudomonas otitidis MCC 10330(MIC=14.18 ?g/ml); Pseudomonas otitidis MCC 10330(MBC=14.18 ?g/ml); Klebsiella pneumoniae ATCC 35657(MIC=9.88 ?g/ml); Klebsiella pneumoniae ATCC 35657(MBC=9.88 ?g/ml); Salmonella enteritidis ATCC 9120(MIC=4.93 ?g/ml); Salmonella enteritidis ATCC 9120(MBC=4.93 ?g/ml).	[Ref.30607494]non-hemolysis to Sheep erythrocytes up to 224 ?g/ml.	Linear	Free	Free	None	L	[Ref.30607494]No cytotoxicity information found.	liposomes	30607494	Appl Microbiol Biotechnol. 2019 Feb;103(4):1765-1775.	"Wang M, Lin J, Sun Q, Zheng K, Ma Y, Wang J."	"Design, expression, and characterization of a novel cecropin A-derived peptide with high antibacterial activity. "
DRAMP29104	LNLKALLAVAKKIL	14	Mastoparan-C(MP-C)	P01516	Not found	N/A	Vespa crabro	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,24.85% ¦Á-helix was determined in 50% TFE."	None	"Function:The peptide was tolerant in the presence of physiological salts.MP-C  lost antimicrobial activities after incubation with 20 ¦Ìg/mL trypsin or chymotrypsin,indicating moderate protease resistance."	"[Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=2 ?M); Staphylococcus aureus NCTC 10788(MBC=2 ?M); Staphylococcus aureus ATCC 12493(MRSA,MIC=4 ?M); Staphylococcus aureus ATCC 12493(MRSA,MBC=4 ?M); Enterococcus faecalis NCTC 12697(MIC=8 ?M); Enterococcus faecalis NCTC 12697(MBC=8 ?M);##Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=4 ?M); Escherichia coli NCTC 10418(MBC=8 ?M); Pseudomonas aeruginosa ATCC 27853(MIC=8 ?M); Pseudomonas aeruginosa ATCC 27853(MBC=16 ?M);    Fungi:Candida albicans NCTC 1467(MIC=4 ?M); Candida albicans NCTC 1467(MBC=4 ?M);##Cancer:Human squamous lung carcinoma NCI-H157(IC50=13.57 ?M);Human breast adenocarcinoma MDA-MB-435S(IC50=27.70 ?M);Human prostate adenocarcinoma PC-3(IC50=6.29 ?M);Human glioblastoma U251-MG(IC50=36.65 ?M); Human breast adenocarcinoma MCF-7(IC50=25.27 ?M).##[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacterial:Escherichia coli ATCC 25922(4.5 mM KCl and 0.004 mM FeCl3,MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(4.5 mM KCl,MIC=8 ?M); Klebsiella pneumoniae ATCC 700603(MIC=8 ?M); Escherichia coli ATCC 25922(NaCl/MgCl2=150mM/1mM,MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(NaCl/MgCl2=150mM/1mM,MIC=16 ?M); Pseudomonas aeruginosa ATCC 9027(0.004mM FeCl3,MIC=4 ?M);Escherichia coli(Rifampin-resistant strain,MIC=4 ?M)."	[Ref.29904274]50% hemolysis against horse erythrocytes at 40.11 ?M.##[Ref.33285267]10% hemolysis against mouse erythrocytes at 64 ?M; 60% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=57.15 ?M).##[Ref.33285267]90% Killing against Human embryonic kidney HEK293T cells at 128 ?M; Human embryonic kidney HEK293T cells(IC50=16 ?M).	liposomes	33285267##29904274	Eur J Pharm Sci. 2021 Mar 1;158:105665.##Int J Biol Sci. 2018 Apr 25;14(6):599-607.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J. ##Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.##Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering.
DRAMP29105	CLNLKALLAVAKKILC	16	c Mastoparan-C(cMP-C)	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal"	Protein level	"Alpha helix,random coil"	"76% ¦Á-helix was determined from the circular dichroism spectra recorded in 50% TFE/10mM NH4AC solution,28% of the secondary structure  retained an ¦Á-helical domain in an aqueous environment."	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=32 ?M); Staphylococcus aureus NCTC 10788(MBC=64 ?M); Staphylococcus aureus ATCC 12493(MRSA,MIC=128 ?M); Staphylococcus aureus ATCC 12493(MRSA,MBC=128 ?M); Enterococcus faecalis NCTC 12697(MIC=128 ?M); Enterococcus faecalis NCTC 12697(MBC=128 ?M);##Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=32 ?M); Escherichia coli NCTC 10418(MBC=128 ?M); Pseudomonas aeruginosa ATCC 27853(MIC=32 ?M); Pseudomonas aeruginosa ATCC 27853(MBC>512 ?M);##Fungi:Candida albicans NCTC 1467(MIC=32 ?M); Candida albicans NCTC 1467(MBC=128 ?M);##Cancer:Human squamous lung carcinoma NCI-H157(IC50=7.02 ?M);Human breast adenocarcinoma MDA-MB-435S(IC50=13.87 ?M);Human prostate adenocarcinoma PC-3(IC50=13.87 ?M);Human glioblastoma U251-MG(IC50=8.56 ?M); Human breast adenocarcinoma MCF-7(IC50=13.66 ?M).       "	[Ref.29904274]50% hemolysis against horse erythrocytes at 9.19 ?M.    	Cyclic	Free	Amidation	Disulfide bond (Cys1-Cys16)	L	[Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=39.53 ?M).  	liposomes	29904274	Int J Biol Sci. 2018 Apr 25;14(6):599-607.	"Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M."	Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering.
DRAMP29106	RKKRRQRRRLNLKALLAVAKKIL	23	"t Mastoparan-C(tMP-C, Tat (49-57)-Mastoparan-C)"	"P01516,Q76PP9"	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal"	Protein level	"Alpha helix,random coil"	"28% ¦Á-helix was determined from the circular dichroism spectra recorded in 50% TFE/10mM NH4AC solution,and it adopted a random coil structure in an aqueous environment."	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	"[Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=4 ?M); Staphylococcus aureus NCTC 10788(MBC=4 ?M); Staphylococcus aureus ATCC 12493(MRSA,MIC=4 ?M); Staphylococcus aureus ATCC 12493(MRSA,MBC=8 ?M); Enterococcus faecalis NCTC 12697(MIC=8 ?M); Enterococcus faecalis NCTC 12697(MBC=16 ?M);##Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=2 ?M); Escherichia coli NCTC 10418(MBC=2 ?M); Pseudomonas aeruginosa ATCC 27853(MIC=4 ?M); Pseudomonas aeruginosa ATCC 27853(MBC=4 ?M);##Fungi:Candida albicans NCTC 1467(MIC=2 ?M); Candida albicans NCTC 1467(MBC=2 ?M);##Cancer:Human squamous lung carcinoma NCI-H157(IC50=2.79 ?M);Human breast adenocarcinoma MDA-MB-435S(IC50=3.86 ?M);Human prostate adenocarcinoma PC-3(IC50=3.86 ?M);Human glioblastoma U251-MG(IC50=3.36 ?M); Human breast adenocarcinoma MCF-7(IC50=3.70 ?M).     "	[Ref.29904274]50% hemolysis against horse erythrocytes at 77.94 ?M.    	Linear	Free	Amidation	None	L	[Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=9.18 ?M).  	liposomes	29904274	Int J Biol Sci. 2018 Apr 25;14(6):599-607.	"Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M."	Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering.
DRAMP29107	ANLKALLAVAKKIL	14	Mastoparan-C [L1A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,43.88% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=32 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=16 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M).	[Ref.33285267]2% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29108	LALKALLAVAKKIL	14	Mastoparan-C [N2A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,19.52% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=8 ?M); Klebsiella pneumoniae ATCC 700603(MIC=8 ?M).	"[Ref.33285267]10% hemolysis against mouse erythrocytes at 128 ?M,50% hemolysis against mouse erythrocytes at 256 ?M."	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29109	LNAKALLAVAKKIL	14	Mastoparan-C [L3A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,4.24% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=32 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=32 ?M); Klebsiella pneumoniae ATCC 700603(MIC=32 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29110	LNLAALLAVAKKIL	14	Mastoparan-C [K4A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,27.41% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4 ?M); Bacillus subtilis ATCC 23857(MIC=16 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=32 ?M); Klebsiella pneumoniae ATCC 700603(MIC=32 ?M).	"[Ref.33285267]10% hemolysis against mouse erythrocytes at 128 ?M,52% hemolysis against mouse erythrocytes at 256 ?M."	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29111	LNLKAALAVAKKIL	14	Mastoparan-C [L6A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,44.72% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=32 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=32 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29112	LNLKALAAVAKKIL	14	Mastoparan-C [L7A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,34.08% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	"[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=16 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M); ##Gram-negative bacteria:Escherichia coli ATCC 25922(4.5 mM KCl and 0.004 mM FeCl3,MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(4.5 mM KCl,MIC=16 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M); Escherichia coli ATCC 25922(150mM NaCl,MIC=32 ?M); Escherichia coli ATCC 25922(1mM MgCl2,MIC=16 ?M); Pseudomonas aeruginosa ATCC 9027(150mM NaCl,MIC=32 ?M); Pseudomonas aeruginosa ATCC 9027(1mM MgCl2,MIC=64 ?M); Pseudomonas aeruginosa ATCC 9027(0.004mM FeCl3,MIC=8 ?M);Escherichia coli(Rifampin-resistant strain,MIC=8 ?M)."	[Ref.33285267]8% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]45% Killing against Human embryonic kidney HEK293T cells at 128 ?M; Human embryonic kidney HEK293T cells(IC50>128 ?M).	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29113	LNLKALLAAAKKIL	14	Mastoparan-C [V9A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,7.45% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=16 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=16 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M).	[Ref.33285267]20% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29114	LNLKALLAVAAKIL	14	Mastoparan-C [K11A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,16.69% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4 ?M); Bacillus subtilis ATCC 23857(MIC=16 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=32 ?M); Klebsiella pneumoniae ATCC 700603(MIC=32 ?M).	[Ref.33285267]18% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29115	LNLKALLAVAKAIL	14	Mastoparan-C [K12A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,37.54% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=16 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M).	"[Ref.33285267]10% hemolysis against mouse erythrocytes at 32 ?M,90% hemolysis against mouse erythrocytes at 256 ?M."	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29116	LNLKALLAVAKKAL	14	Mastoparan-C [I13A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,8.91% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=32 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=32 ?M); Klebsiella pneumoniae ATCC 700603(MIC=32 ?M).	[Ref.33285267]5% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29117	LNLKALLAVAKKIA	14	Mastoparan-C [L14A]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,15.36% ¦Á-helix was determined in 60% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=32 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=16 ?M); Klebsiella pneumoniae ATCC 700603(MIC=32 ?M).	[Ref.33285267]5% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29118	GNLKALLAVAKKIL	14	Mastoparan-C [L1G]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,16.12% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	"[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=32 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(4.5 mM KCl and 0.004 mM FeCl3,MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(0.004 mM FeCl3,MIC=8 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M); Escherichia coli ATCC 25922(150mM NaCl,MIC=8 ?M); Escherichia coli ATCC 25922(1mM MgCl2,MIC=16 ?M); Pseudomonas aeruginosa ATCC 9027(150mM NaCl,MIC=32 ?M); Pseudomonas aeruginosa ATCC 9027(4.5mM KCl,MIC=16 ?M); Pseudomonas aeruginosa ATCC 9027(1mM MgCl2,MIC=64 ?M);Escherichia coli(Rifampin-resistant strain,MIC=8 ?M)."	[Ref.33285267]8% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]80% Killing against Human embryonic kidney HEK293T cells at 128 ?M; Human embryonic kidney HEK293T cells(IC50=128 ?M).	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29119	LNLKALGAVAKKIL	14	Mastoparan-C [L7G]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,7.26% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=128 ?M); Bacillus subtilis ATCC 23857(MIC=32 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=32 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=32 ?M); Klebsiella pneumoniae ATCC 700603(MIC=64 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29120	KNLKALLAVAKKIL	14	Mastoparan-C [L1K]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,18.62% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=64 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=8 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29121	GNLKALAAVAKKIL	14	"Mastoparan-C [L1G, L7A]"	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,1.61% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC>128 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=64 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=64 ?M); Klebsiella pneumoniae ATCC 700603(MIC=128 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29122	LNLRALLAVARRIL	14	"Mastoparan-C [K4,11,12R]"	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,24.8% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=8 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M).	"[Ref.33285267]10% hemolysis against mouse erythrocytes at 32 ?M,87% hemolysis against mouse erythrocytes at 256 ?M."	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29123	LNLKKLLAVAKKIL	14	Mastoparan-C [A5K]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,25.08% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=8 ?M); Bacillus subtilis ATCC 23857(MIC=2 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=4 ?M); Klebsiella pneumoniae ATCC 700603(MIC=4 ?M).	"[Ref.33285267]10% hemolysis against mouse erythrocytes at 128 ?M,30% hemolysis against mouse erythrocytes at 256 ?M."	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29124	LNLKKLLKVAKKIL	14	"Mastoparan-C [A5,8K]"	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,3.56% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=16 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=4 ?M); Klebsiella pneumoniae ATCC 700603(MIC=8 ?M).	[Ref.33285267]15% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29125	LNLKALLAVAKKI	13	Mastoparan-C (1-13)	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,16.87% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=64 ?M); Bacillus subtilis ATCC 23857(MIC=16 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=16 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=32 ?M); Klebsiella pneumoniae ATCC 700603(MIC=64 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29126	LNLKALLAVAKK	12	Mastoparan-C (1-12)	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,8.04% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC>128 ?M); Bacillus subtilis ATCC 23857(MIC>128 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC>128 ?M); Pseudomonas aeruginosa ATCC 9027(MIC>128 ?M); Klebsiella pneumoniae ATCC 700603(MIC>128 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29127	LNLKALLAVAK	11	Mastoparan-C (1-11)	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,24.68% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC>128 ?M); Bacillus subtilis ATCC 23857(MIC>128 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC>128 ?M); Pseudomonas aeruginosa ATCC 9027(MIC>128 ?M); Klebsiella pneumoniae ATCC 700603(MIC>128 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29128	GNLKKLLAVAKKIL	14	"Mastoparan-C [L1G, A5K]"	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,22.26% ¦Á-helix was determined in50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	"[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=16 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(4.5 mM KCl and 0.004 mM FeCl3,MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(0.004 mM FeCl3,MIC=4 ?M); Klebsiella pneumoniae ATCC 700603(MIC=16 ?M); Escherichia coli ATCC 25922(150mM NaCl,MIC=16 ?M); Escherichia coli ATCC 25922(1mM MgCl2,MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(NaCl/MgCl2=150mM/1mM,MIC=32 ?M); Pseudomonas aeruginosa ATCC 9027(4.5mM KCl,MIC=16 ?M); Escherichia coli(Rifampin-resistant strain,MIC=4 ?M)."	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]65% Killing against Human embryonic kidney HEK293T cells at 128 ?M; Human embryonic kidney HEK293T cells(IC50=128 ?M).	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29129	LNLKKLAAVAKKIL	14	"Mastoparan-C [A5K, L7A]"	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,8.55% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=32 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=8 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=4 ?M); Klebsiella pneumoniae ATCC 700603(MIC=32 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29130	LNLKKLLAVAKKI	13	Mastoparan-C (1-13) [A5K]	P01516	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Protein level	"Alpha helix,random coil"	"The CD spectra in water adopts a random-coil conformation,4.42% ¦Á-helix was determined in 50% TFE."	None	"Function:when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027."	[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=128 ?M); Bacillus subtilis ATCC 23857(MIC=8 ?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=16 ?M); Pseudomonas aeruginosa ATCC 9027(MIC=16 ?M); Klebsiella pneumoniae ATCC 700603(MIC=64 ?M).	[Ref.33285267]0% hemolysis against mouse erythrocytes at 256 ?M.	Linear	Free	Amidation	None	L	[Ref.33285267]No cytotoxicity information found.	liposomes	33285267	Eur J Pharm Sci. 2021 Mar 1;158:105665.	"Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J."	Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
DRAMP29131	KLLGPLLKIAAKVGSNLL	18	XT-7 [G1K]	P84381	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=25 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=12.5 ?M);##Fungi:Candida albicans ATCC 900280(MIC=50 ?M);##Cancer:human hepatoma©\derived cells HepG2 (LC50=230 ?M).	[Ref.18554256]Hemolysis against human erythrocytes (LC50=400 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]No cytotoxicity information found.	liposomes	18554256	Chem Biol Drug Des. 2008 Jul;72(1):58-64.	"Conlon JM, Galadari S, Raza H, Condamine E."	"Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29132	GLLGKLLKIAAKVGSNLL	18	XT-7 [P5K]	P84381	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Alpha helix	53% ¦Á-helix was determined from the circular dichroism spectra recorded in 50% trifluoroethanol-water.	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=12.5 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=3 ?M);##Fungi:Candida albicans ATCC 900280(MIC=6 ?M);##Cancer:human hepatoma©\derived cells HepG2 (LC50=14 ?M).	[Ref.18554256]Hemolysis against human erythrocytes (LC50=15 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]No cytotoxicity information found.	liposomes	18554256	Chem Biol Drug Des. 2008 Jul;72(1):58-64.	"Conlon JM, Galadari S, Raza H, Condamine E."	"Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29133	GLLGPLLKIAKKVGSNLL	18	XT-7 [A11K]	P84381	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=50 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=25 ?M);##Fungi:Candida albicans ATCC 900280(MIC=25 ?M);##Cancer:human hepatoma©\derived cells HepG2 (LC50=65 ?M).	[Ref.18554256]Hemolysis against human erythrocytes (LC50=350 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]No cytotoxicity information found.	liposomes	18554256	Chem Biol Drug Des. 2008 Jul;72(1):58-64.	"Conlon JM, Galadari S, Raza H, Condamine E."	"Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29134	GLLGPLLKIAAKVGKNLL	18	XT-7 [S15K]	P84381	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=12.5 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=3 ?M);##Fungi:Candida albicans ATCC 900280(MIC=25 ?M);##Cancer:human hepatoma©\derived cells HepG2 (LC50=24 ?M).	[Ref.18554256]Hemolysis against human erythrocytes (LC50=110 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]No cytotoxicity information found.	liposomes	18554256	Chem Biol Drug Des. 2008 Jul;72(1):58-64.	"Conlon JM, Galadari S, Raza H, Condamine E."	"Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29135	GLLGPLLKIAAKVGKKLL	18	"XT-7 [S15K,N16K]"	P84381	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=50 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=6 ?M);##Fungi:Candida albicans ATCC 900280(MIC=6 ?M);##Cancer:hepatoma©\derived cells HepG2 (LC50=10 ?M).	[Ref.18554256]Hemolysis against human erythrocytes (LC50=60 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]No cytotoxicity information found.	liposomes	18554256	Chem Biol Drug Des. 2008 Jul;72(1):58-64.	"Conlon JM, Galadari S, Raza H, Condamine E."	"Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29136	GLLGPLLKIAAKVGSKLL	18	XT-7 [N16K]	P84381	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.23094651]Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=6.3 ?M).##[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=12.5 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=3 ?M);##Fungi:Candida albicans ATCC 900280(MIC=12.5 ?M);##Cancer: human hepatoma©\derived cells HepG2 (LC50=22 ?M).	[Ref.23094651]50% hemolysis against rat erythrocytes at 142 ?M.##[Ref.18554256]Hemolysis against human erythrocytes (LC50=80 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]No cytotoxicity information found.	liposomes	23094651##18554256	 J Chem Inf Model. 2012 Dec 21;52(12):3341-51.##Chem Biol Drug Des. 2008 Jul;72(1):58-64.	"Kamech N, Vuki?evi? D, Ladram A, Piesse C, Vasseur J, Bojovi? V, Simuni? J, Jureti? D.##Conlon JM, Galadari S, Raza H, Condamine E."	"Improving the selectivity of antimicrobial peptides from anuran skin.##Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29137	GLLGKLLKIAAKVGKKLL	18	"XT-7 [P5K,S15K,N16K]"	P84381	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=25 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=3 ?M);##Fungi:Candida albicans ATCC 900280(MIC=3 ?M);##Cancer:human hepatoma©\derived cells HepG2 (LC50=5 ?M).	[Ref.18554256]Hemolysis against human erythrocytes (LC50=25 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]No cytotoxicity information found.	liposomes	18554256	Chem Biol Drug Des. 2008 Jul;72(1):58-64.	"Conlon JM, Galadari S, Raza H, Condamine E."	"Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29138	GLLKKLLKIAAKVGKKLL	18	"XT-7 [G4K,P5K,S15K,N16K]"	P84381	Not found	N/A	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Protein level	Not found	Not found	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.	[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=12.5 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=6 ?M);##Fungi:Candida albicans ATCC 900280(MIC=3 ?M);##Cancer: human hepatoma©\derived cells HepG2 (LC50=6 ?M).	[Ref.18554256]Hemolysis against human erythrocytes (LC50=25 ?M).	Linear	Free	Amidation	None	L	[Ref.18554256]No cytotoxicity information found.	liposomes	18554256	Chem Biol Drug Des. 2008 Jul;72(1):58-64.	"Conlon JM, Galadari S, Raza H, Condamine E."	"Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7."
DRAMP29139	IRPIPFIPRGGKT	13	Pxt©\1	No entry found	Not found	Not found	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,random coil"	"10.9%,12.2%,12.7% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2)."	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.25312021]Gram-negative bacteria:Escherichia coli DH5¦Á(Not active up to 150 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus JCM 2151(Not active up to 150 ?g/ml).	[Ref.25312021]0.1% Hemolysis against Rat erythrocytes at 20 ?M.	Linear	Free	Amidation	None	L	[Ref.25312021]No cytotoxicity information found.	Not found	25312021	FEBS J. 2015 Jan;282(1):102-13.	"Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Identification of novel peptides from amphibian (Xenopus?tropicalis) skin by direct tissue MALDI-MS analysis.
DRAMP29140	FIGALLRPALKLLA	14	Pxt©\2	No entry found	Not found	Not found	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Not found	"Alpha helix,random coil"	"3.8%,4.0%,4.9% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2)."	None	Function:showed growth inhibitory effects on both Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive).	[Ref.25312021]Gram-negative bacteria:Escherichia coli DH5¦Á(MIC=50 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus JCM 2151(MIC=9.7 ?g/ml).##[Ref.26802742]Gram-negative bacteria:Escherichia coli NBRC 14237(MIC<12.5 ?M);Pseudomonas aeruginosa NBRC 12582(MIC<50 ?M);##Gram-positive bacteria:Staphylococcus aureus NBRC 12732(MIC<12.5 ?M);Micrococcus luteus NBRC 12708(MIC<25 ?M);##Fungi:Saccharomyces cerevisiae NBRC 10217(ND);Candida albicans NBRC 1594(ND). 	[Ref.25312021]0.4% Hemolysis against Rat erythrocytes at 20 ?M.##[Ref.26802742]2% Hemolysis against Rat erythrocytes at 50 ?M.	Linear	Free	Amidation	None	L	[Ref.25312021]No cytotoxicity information found.	Not found	25312021##26802742	FEBS J. 2015 Jan;282(1):102-13.##J Biochem. 2016 Jun;159(6):619-29.	"Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M.##Shigeri Y, Horie M, Yoshida T, Hagihara Y, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Identification of novel peptides from amphibian (Xenopus?tropicalis) skin by direct tissue MALDI-MS analysis.##Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin.
DRAMP29141	GLKEVAHSAKKFAKGFISGLTGS	23	Pxt©\3	No entry found	Not found	Not found	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Not found	"Alpha helix,random coil"	"0.5%,1.2%,2.0% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2)."	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.25312021]Gram-negative bacteria:Escherichia coli DH5¦Á(Not active up to 150 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus JCM 2151(Not active up to 150 ?g/ml).##[Ref.23935531]Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=64 ?m);Pseudomonas aeruginosa ATCC 15692(MIC >256 ?M);##Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC >256 ?M);Micrococcus luteus(MIC=32 ?M);##Fungi:Saccharomyces cerevisiae(MIC=128 ?M);##Parasite:Trypanosoma brucei(LC95=8->256 ?M).   	[Ref.25312021]0.2% Hemolysis against Rat erythrocytes at 20 ?M.##[Ref.23935531] Hemolysis against Mouse erythrocytes (HC50>256 ?m).	Linear	Free	Free	None	L	[Ref.23935531]Cytotoxicity against T-lymphocytes(IC50>256 ?M).	Not found	25312021##23935531	FEBS J. 2015 Jan;282(1):102-13.##PLoS Genet. 2013;9(8):e1003662.	"Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M.##Roelants K, Fry BG, Ye L, Stijlemans B, Brys L, Kok P, Clynen E, Schoofs L, Cornelis P, Bossuyt F."	Identification of novel peptides from amphibian (Xenopus?tropicalis) skin by direct tissue MALDI-MS analysis.##Origin and functional diversification of an amphibian defense peptide arsenal.
DRAMP29142	LKGASKLIPHLLPSRQQ	17	Pxt©\4	No entry found	Not found	Not found	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,random coil"	"1.8%,2.8%,3.9% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2)."	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.25312021]Gram-negative bacteria:Escherichia coli DH5¦Á(Not active up to 150 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus JCM 2151(Not active up to 150 ?g/ml).	[Ref.25312021]0.1% Hemolysis against Rat erythrocytes at 20 ?M.	Linear	Free	Free	None	L	[Ref.25312021]No cytotoxicity information found.	Not found	25312021	FEBS J. 2015 Jan;282(1):102-13.	"Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Identification of novel peptides from amphibian (Xenopus?tropicalis) skin by direct tissue MALDI-MS analysis.
DRAMP29143	FIGALLGPLLNLLK	14	Pxt©\5	No entry found	Not found	Not found	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,random coil"	"37.4%,36.5%,34.6% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2)."	None	Function:showed growth inhibitory effects on both Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive).	[Ref.25312021]Gram-negative bacteria:Escherichia coli DH5¦Á(Not active up to 150 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus JCM 2151(Not active up to 150 ?g/ml).	[Ref.25312021]10.5% Hemolysis against Rat erythrocytes at 20 ?M.	Linear	Free	Amidation	None	L	[Ref.25312021]No cytotoxicity information found.	Not found	25312021	FEBS J. 2015 Jan;282(1):102-13.	"Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Identification of novel peptides from amphibian (Xenopus?tropicalis) skin by direct tissue MALDI-MS analysis.
DRAMP29144	IRPVPFFPPVHAKKVFPLH	19	Pxt©\6	No entry found	Not found	Not found	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,random coil"	"2.3%,5.1%,7.4% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2)."	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.25312021]Gram-negative bacteria:Escherichia coli DH5¦Á(Not active up to 150 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus JCM 2151(Not active up to 150 ?g/ml).	[Ref.25312021]0.3% Hemolysis against Rat erythrocytes at 20 ?M.	Linear	Free	Free	None	L	[Ref.25312021]No cytotoxicity information found.	Not found	25312021	FEBS J. 2015 Jan;282(1):102-13.	"Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Identification of novel peptides from amphibian (Xenopus?tropicalis) skin by direct tissue MALDI-MS analysis.
DRAMP29145	GGLIGTLTAKQIKK	14	Pxt-7	No entry found	Not found	Not found	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,random coil"	"2.6%,2.8%,6.6% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2)."	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.25312021]Gram-negative bacteria:Escherichia coli DH5¦Á(Not active up to 150 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus JCM 2151(Not active up to 150 ?g/ml).	[Ref.25312021]0.4% Hemolysis against Rat erythrocytes at 20 ?M.	Linear	Free	Amidation	The 'G' at position 1 is pyroglutamic acid	L	[Ref.25312021]No cytotoxicity information found.	Not found	25312021	FEBS J. 2015 Jan;282(1):102-13.	"Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Identification of novel peptides from amphibian (Xenopus?tropicalis) skin by direct tissue MALDI-MS analysis.
DRAMP29146	GLMGTLISKQMKK	13	Pxt©\11	No entry found	Not found	Not found	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-"	Not found	"Alpha helix,random coil"	"2.3%,4.2%,6.6% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2)."	None	Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.	[Ref.25312021]Gram-negative bacteria:Escherichia coli DH5¦Á(Not active up to 150 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus JCM 2151(Not active up to 150 ?g/ml).	[Ref.25312021]0.3% Hemolysis against Rat erythrocytes at 20 ?M.	Linear	Free	Amidation 	The 'G' at position 1 is pyroglutamic acid	L	[Ref.25312021]No cytotoxicity information found.	Not found	25312021	FEBS J. 2015 Jan;282(1):102-13.	"Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Identification of novel peptides from amphibian (Xenopus?tropicalis) skin by direct tissue MALDI-MS analysis.
DRAMP29147	NLLGSLLKTGLKVGSNLL	18	Pxt©\12(CPF-St7)	P84386	Not found	N/A	Xenopus tropicalis	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-,Antifungal"	Protein level	"Alpha helix,random coil"	"0%,2.5%,6.6% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2);68.2%,57.4%,50.5% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 50% TFE."	None	Induced a significant and dose-dependent histamine release. 	[Ref.26802742]Gram-negative bacteria:Escherichia coli NBRC 14237(MIC<12.5 ?M);Pseudomonas aeruginosa NBRC 12582(MIC<50 ?M);##Gram-positive bacteria:Staphylococcus aureus NBRC 12732(MIC<12.5 ?M);Micrococcus luteus NBRC 12708(MIC<50 ?M);##Fungi:Candida albicans NBRC 1594(ND). ##[Ref.23935531]Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=128 ?M);Pseudomonas aeruginosa ATCC 15692(MIC >256 ?M);##Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=32 ?M);Micrococcus luteus(MIC=2 ?M);##Fungi:Saccharomyces cerevisiae(MIC=64 ?M);##Parasite:Trypanosoma brucei(LC95=2-64 ?M).     	[Ref.26802742]0% Hemolysis against Rat erythrocytes at 50 ?M.##[Ref.23935531]Hemolysis against Mouse erythrocytes(IC50=256 ?M).	Linear	Free	Amidation 	None	L	[Ref.23935531]Cytotoxicity against T-lymphocytes(IC50=128 ?M). 	liposomes	26802742##23935531	J Biochem. 2016 Jun;159(6):619-29.##PLoS Genet. 2013;9(8):e1003662. 	"Shigeri Y, Horie M, Yoshida T, Hagihara Y, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M.##Roelants K, Fry BG, Ye L, Stijlemans B, Brys L, Kok P, Clynen E, Schoofs L, Cornelis P, Bossuyt F."	Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin.##Origin and functional diversification of an amphibian defense peptide arsenal.
DRAMP29148	KLLNLLPGLLAGIF	14	Reverse Pxt©\5	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Not found	"Alpha helix,random coil"	"10.9%,17.4%,19.8% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2);87.1%,77.0%,70.7% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 50% TFE."	None	Induced a significant and dose-dependent histamine release. 	[Ref.26802742]Gram-negative bacteria:Escherichia coli NBRC 14237(MIC<12.5 ?M);Pseudomonas aeruginosa NBRC 12582(MIC<50 ?M);##Gram-positive bacteria:Staphylococcus aureus NBRC 12732(MIC<12.5 ?M);Micrococcus luteus NBRC 12708(MIC<25 ?M);##Fungi:Candida albicans NBRC 1594(ND). 	[Ref.26802742]5.2% Hemolysis against Rat erythrocytes at 50 ?M.	Linear	Free	Amidation 	None	L	[Ref.26802742]No cytotoxicity information found.	liposomes	26802742	J Biochem. 2016 Jun;159(6):619-29.	"Shigeri Y, Horie M, Yoshida T, Hagihara Y, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin.
DRAMP29149	ALLKLAPRLLAGIF	14	Reverse Pxt-2	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Not found	"Alpha helix,random coil"	"3.6%,4.7%,7.3% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2);28.6%,26.8%,22.8% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 50% TFE."	None	Induced a significant and dose-dependent histamine release. 	[Ref.26802742]Gram-negative bacteria:Escherichia coli NBRC 14237(MIC<12.5 ?M);Pseudomonas aeruginosa NBRC 12582(MIC<50 ?M);##Gram-positive bacteria:Staphylococcus aureus NBRC 12732(MIC<12.5 ?M);Micrococcus luteus NBRC 12708(MIC<50 ?M);##Fungi:Candida albicans NBRC 1594(ND). 	[Ref.26802742]1.5% Hemolysis against Rat erythrocytes at 50 ?M.	Linear	Free	Amidation	None	L	[Ref.26802742]No cytotoxicity information found.	liposomes	26802742	J Biochem. 2016 Jun;159(6):619-29.	"Shigeri Y, Horie M, Yoshida T, Hagihara Y, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin.
DRAMP29150	LLNSGVKLGTKLLSGLLN	18	Reverse Pxt-12	No entry found	Not found	Not found	Synthetic construct	"Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal"	Not found	"Alpha helix,random coil"	"0%,0%,2.0% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 10 mm Tris-HCl (pH 7.2);23.7%,21.0%,17.9% ¦Á-helix were mearsured by CD spectra at 10 ¡ãC, 25 ¡ãC and 37 ¡ãC in 50% TFE."	None	Induced a significant and dose-dependent histamine release. 	[Ref.26802742]Gram-negative bacteria:Escherichia coli NBRC 14237(ND);Pseudomonas aeruginosa NBRC 12582(ND);##Gram-positive bacteria:Staphylococcus aureus NBRC 12732(ND);Micrococcus luteus NBRC 12708(ND);##Fungi:Candida albicans NBRC 1594(ND). 	[Ref.26802742]0% Hemolysis against Rat erythrocytes at 50 ?M.	Linear	Free	Amidation	None	L	[Ref.26802742]No cytotoxicity information found.	liposomes	26802742	J Biochem. 2016 Jun;159(6):619-29.	"Shigeri Y, Horie M, Yoshida T, Hagihara Y, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M."	Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin.