DRAMP_ID Sequence Sequence_Length Name Swiss_Prot_Entry Family Gene Source Activity Protein_existence Structure Structure_Description PDB_ID Comments Target_Organism Hemolytic_activity Linear/Cyclic/Branched N-terminal_Modification C-terminal_Modification Other_Modifications Stereochemistry Cytotoxicity Binding_Traget Pubmed_ID Reference Author Title DRAMP00005 SLGPAIKATRQVCPKATRFVTVSCKKSDCQ 30 Epicidin 280 (Bacteriocin) O54220 Belongs to the lantibiotic family (Class I bacteriocin) eciA Staphylococcus epidermidis BN 280 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Lanthionine-containing peptide antibiotic (lantibiotic) Transiently and partially depolarizes the transmembrane electrical potential and pH gradient of susceptible cells, inhibits the uptake of amino acids and depletes the intracellular ATP pool. PTM: Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor." "Gram-positive bacteria: Staphylococcus simulans 22 (MIC=0.304 g/ml), Staphylococcus epidermidis 5 (MIC=3.85 g/ml), Micrococcus luteus ATCC4698 (MIC=9.7 g/ml), Staphylococcus carnosus TM300 (MIC=0.175 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic (very possibly) Oxypropionylation Not metioned clearly "There are possible lanthionine(Lan)/3-methyllanthionine(Me-Lan) structure association between Thr9 and Cys13, Thr21 and Cys24, Ser23 and Cys29." L No cytotoxicity information found Not found 9726851 Appl Environ Microbiol. 1998 Sep;64(9):3140-3146. "Heidrich C, Pag U, Josten M, Metzger J, Jack RW, Bierbaum G, Jung G, Sahl HG." "Isolation, characterization, and heterologous expression of the novel lantibiotic epicidin 280 and analysis of its biosynthetic gene cluster." DRAMP00017 VTSWSLCTPGCTSPGGGSNCSFCC 24 Microbisporicin A1 (Bacteriocin) No entry found Belongs to the lantibiotic family (Class I bacteriocin) Not found Microbispora corallina (Gram-positive bacteria) "Antimicrobial, Antibacterial" Protein level Rich Not found None "Function: Microbisporicins A1 displayed similar antibacterial activity by selectively blocking peptidoglycan biosynthesis, leading to cytoplasmic accumulation of the UDP-linked precursor. PTM: Microbisporicin A1 contains five ether rings: S3-C7, T8-C11, S13-C20, S18-C23, and S21-C24. Also, residues T2 and S5 are dehydrated, Trp4 is chlorinated and Pro14 is hydroxylated (3,4-dihydroxylation)." "Human pathogens: L100 Staphylococcus aureus ATCC6538P (MIC0.13 g/ml), L819 Staphylococcus aureus Smith ATCC19636 (MIC0.13 g/ml), L1400 S. aureus MRSA (MIC0.13 g/ml), L613 S. aureus MRSA (MIC0.13 g/ml), L3798 S. aureus VISA (MIC=2 g/ml), L3798 Staphylococcus epidermidis ATCC12228 (MIC0.13 g/ml), L1729 Staphylococcus haemolyticus met-r (MIC=8 g/ml), L49 Streptococcus pyogenes (MIC0.13 g/ml), L44 Streptococcus pneumoniae (MIC0.13 g/ml), L559 Enterococcus faecalis (MIC=1 g/ml), L560 Enterococcus faecalis Van A (MIC=0.5 g/ml), LA533 Enterococcus faecalis Van A (MIC=1 g/ml), L568 Enterococcus faecium (MIC=2 g/ml), L569 Enterococcus faecium Van A (MIC=1 g/ml), LB518 E. faecium Van A (MIC=2 g/ml), L884 Lactobacillus garviae (MIC=1 g/ml), L148 Lactobacillus delbrueckii ATCC04797 (MIC=4 g/ml), L3607 Clostridium perfringens ATCC13124 (MIC0.125 g/ml), L4018 Clostridium difficile (MIC0.125 g/ml), L4043 Clostridium butyricum (MIC0.125 g/ml), Propionibacterium granulosum ATCC25564 (MIC=0.03 g/ml), L1329 Propionibacterium acnes (MIC=0.5 g/ml), Propionibacterium limphophylum ATCC27250 (MIC=0.015 g/ml), L970 Haemophilus influenzae ATCC19418 (MIC=32 g/ml), L76 Moraxella catarrhalis ATCC8176 (MIC=0.25 g/ml), L1613 Neisseria meningitidis ATCC13090V (MIC=0.5 g/ml), L997 Neisseria gonorrhoeae (MIC=0.25 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation and Cyclization "There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). The residue at position 4 is chloro-tryptophan (ClTrp). The residue at position 5 is 2,3-didehydroalanine. The residue at position 8 is 2-Aminobutyric acid (Abu). The residue at position 14 is bis-hydroxylated proline." L No cytotoxicity information found Not found 18215770 Chem Biol. 2008 Jan;15(1):22-31. "Castiglione F, Lazzarini A, Carrano L, Corti E, Ciciliato I, Gastaldo L, Candiani P, Losi D, Marinelli F, Selva E, Parenti F." "Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens." DRAMP00032 GNGVLKTISHECNMNTWQFLFTCC 24 Ruminococcin A (RumA; Bacteriocin) "P83674, P83676, P83677, Q8VLK0, Q9K381, P83675, P83679, P83680, Q8VLK0" Belongs to the type A lantibiotic family (Class I bacteriocin) rumA1 AND rumA2 AND Ruminococcus gnavus & Ruminococcus hansenii (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Ruminococcin A is a broad spectrum bacteriocin exhibiting activity against a wide range of pathogenic clostridia and B.longum. Developmental stage: Highest expression in mid to late logarithmic growth phase, after which expression decreases slowly before leveling off in the stationary growth phase. Induction: By trypsin. PTM: There are one didehydrobutyrine (Dhb) at T16, one lanthionine (S9-23) and two Beta-methyllanthionines (T7-C12; T22-C24)." "Gram-positive bacteria: Bifidobacterium longum (strain: ATCC 15707) (MIC=75 ?g/ml), Bacillus cereus (strain: Z4222, TZ415) (MIC=75 ?g/ml), Eubacterium contortum (strain: ATCC 25540) (MIC=32.5 ?g/ml), Ruminococcus obeum (strain: ATCC 29174) (MIC=32.5 ?g/ml), R. gnavus (strain: ATCC 29149) (MIC=75 ?g/ml), Clostridium perfringens (strain: CpA) (MIC=75 ?g/ml), Clostridium difficile serogroup A (strain: B-1) (MIC=75 ?g/ml), C. difficile serogroup C (strain: C253) (MIC=75 ?g/ml), C. difficile serogroup S3 (strain: 79685) (MIC=75 ?g/ml), C. botulinum type A (strain: CIP 38) (MIC=75 ?g/ml), C. botulinum type B (strain: NCTC 7273) (MIC=75 ?g/ml), C. botulinum type E (strain: NCTC 8266) (MIC=75 ?g/ml), C. bifermentans (strain: NCTC 506) (MIC=75 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic (very possibly) Free Cyclization (possibly) " It is highly probable that (i) Ser9 and the putative Cys23 and (ii) the putative His22 and Thr24 are associated in a Lanthionine (Lan) and a 3-methyllanthionine (Me-Lan) residue, respectively. The residues at position 7 and 16 are (Z)-2,3-didehydrobutyrine (Dhb)." L No cytotoxicity information found Cell membrane 11526013##11741840##12089024 Appl Environ Microbiol. 2001 Sep;67(9):4111-4118.##J Bacteriol. 2002 Jan;184(1):18-28.##Appl Environ Microbiol. 2002 Jul;68(7):3424-3431. "Dabard J, Bridonneau C, Phillipe C, Anglade P, Molle D, Nardi M, Ladir M, Girardin H, Marcille F, Gomez A, Fons M.##Gomez A, Ladir M, Marcille F, Fons M.##Marcille F, Gomez A, Joubert P, Ladir M, Veau G, Clara A, Gavini F, Willems A, Fons M." "Ruminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces.##Trypsin mediates growth phase-dependent transcriptional tegulation of genes involved in biosynthesis of ruminococcin A, a lantibiotic produced by a Ruminococcus gnavus strain from a human intestinal microbiota.##Distribution of genes encoding the trypsin-dependent lantibiotic ruminococcin A among bacteria isolated from human fecal microbiota." DRAMP00063 SSSGWLCTLTIECGTIICACR 21 Lantibiotic michiganin-A (Bacteriocin) Q09T02 Belongs to the type B lantibiotic family (Class I bacteriocin) micA Clavibacter michiganensis subsp. Michiganensis (Gram-positive bacteria) "Antimicrobial, Antibacterial" Protein level Not found Not found None "MOA: The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. PTM: Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. The 62-67 beta-methyllanthionine thioether bond is oxidized to a sulfoxide. This is followed by membrane translocation and cleavage of the modified precursor" Clavibacter michiganensis subspecies sepedonicus strain 2136 (MIC=30 pmol/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "All of the threonine residues undergo dehydration, and three of them interact with cysteines via thioether bonds to form methyllanthionine bridges" L No cytotoxicity information found Not found 16957199 Appl Environ Microbiol. 2006 Sep;72(9):5814-5821. "Holtsmark I, Mantzilas D, Eijsink VG, Brurberg MB." "Purification, characterization, and gene sequence of michiganin A, an actagardine-like lantibiotic produced by the tomato pathogen Clavibacter michiganensis subsp. michiganensis." DRAMP00068 MSWLNFLKYIAKYGKKAVSAAWKYKGKVLEWLNVGPTLEWVWQKLKKIAGL 51 Aureocin A53 (Bacteriocin) Q8GPI4 Belongs to the class II bacteriocin aucA Staphylococcus aureus A53 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix Not found None Function: Antibacterial peptide. It causes membrane permeation. "Gram-positive bacteria: Listeria monocytogenes, Staphylococcus simulans (MIC=100 nM), Staphylococcus aureus (MRSA), Streptococcus agalactiae, Micrococcus luteus (MIC=0.15 nM)." [Ref.12054867] No hemolytic activity was detected when purified aureocin A53 was spotted on sheep blood agar plates (data not shown in the reference). Linear Formylation Free None L No cytotoxicity information found Cell membrane 12054867 J Mol Biol. 2002 Jun 7;319(3):745-756. "Netz DJ, Pohl R, Beck-Sickinger AG, Selmer T, Pierik AJ, Bastos Mdo C, Sahl HG." "Biochemical characterisation and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus." DRAMP00069 EYHLMNGANGYLTRVNGKTVYRVTKDPVSAVFGVISNCWGSAGAGFGPQH 50 Garvieacin Q (GarQ; Bacteriocin) No entry found Belongs to the class II bacteriocin Not found Lactococcus garvieae BCC 43578 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus coagulans JCM 2257, Listeria monocytogenes ATCC 19115, L. garvieae strains, E. faecium D48S52, Lactobacillus plantarum BCC 9546, Lactobacillus sakeii JCM 1157, L. ivanovii DMST 9012 (MIC=0.1-1.6 uM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L "[Ref.22210221] Purified GarQ, up to 1 mg/mL, was not cytotoxic to Vero (African green monkey kidney), HepG (human liver hepatocarcinoma) and Caco-2 (human colon adenocarcinoma) cell lines. Vero, HepG2 and Caco-2 have 94 8, 97 4 and 89 7 % survival with indicated concentration (1mg/mL) of purified garvieacin Q compared to that of untreated control using the MTT assay." Not found 22210221 Appl Environ Microbiol. 2012 Mar;78(5):1619-1623. "Tosukhowong A, Zendo T, Visessanguan W, Roytrakul S, Pumpuang L, Jaresitthikunchai J, Sonomoto K." "Garvieacin Q, a novel class II bacteriocin from Lactococcus garvieae BCC 43578." DRAMP00074 ATRSYGNGVYCNNSKCWVNWGEAKENIAGIVISGWASGLAGMGH 44 Enterocin P (Pediocin-like peptide; Bacteriocin) "O30434, Q0GFE0" Belongs to the class IIa bacteriocin entP Enterococcus faecium P13 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Bridge Not found None "Function: Bacteriocin that inhibits the growth of wide range of Gram-positive bacterial species. Does not inhibit the growth of several strains of Gram-negative bacteria. No hemolytic activity against calf blood. Biophysicochemical properties: pH dependence (Stable between pH 3.0 and pH 7.0); Temperature dependence (Thermostable, retains activity after heating at 100 and 121 degrees Celsius). PTM: Contains one disulfide bond 11-16." "[Ref.9361419]Gram-positive bacteria: Pediococcus acidilactici (MIC=69 ng/ml), Pediococcus pentosaceus FBB61 (MIC=136 ng/ml), P. pntosaceus FBB63 (MIC=18 ng/ml), Lactococcus lactis BB24 (MIC=22 ng/ml), Enterococcus faecium (MIC=2 ng/ml), E. faecalis (MIC=238 ng/ml), Staphylococcus carnosus (MIC=139 ng/ml), Bacillus cereus (MIC=286 ng/ml), Clostridium sporogenes (MIC=4 ng/ml), Clostridium tyrobutyricum 3, 5CT (MIC=559 ng/ml), C. tyrobutyricum 1754 (MIC=412 ng/ml), Propionibacteruim sp P4 (MIC=37 ng/ml), Propionibacteruim sp P6 (MIC=26 ng/ml), Clostridium tyrobutyricum (MIC=4 ng/ml), Clostridium botulinum (MIC=259 ng/ml), Listeria monocytogenes 7973 (MIC=35 ng/ml), L. monocytogenes LI5sv1/2 (MIC=33 ng/ml), L. monocytogenes 5105 (MIC=18 ng/ml), L. monocytogenes L11sv4 (MIC=39 ng/ml), L. monocytogenes Scott A (MIC=125 ng/ml), Listeria innocua (MIC=395 ng/ml), Streptococcus aureus 137 (MIC=190 ng/ml), S. aureus 196E (MIC=407 ng/ml), S. aureus 349 (MIC=221 ng/ml), S. aureus 361 (MIC=294 ng/ml), S. aureus 472 (MIC=269 ng/ml), Lactobacillus curvatus (MIC=17 ng/ml), L. fermentum (MIC=1 ng/ml), L. sake (MIC=144 ng/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 9361419##17103378 Appl Environ Microbiol. 1997 Nov;63(11):4321-4330.##Mol Nutr Food Res. 2006 Dec;50(12):1229-1238. "Cintas LM, Casaus P, H?varstein LS, Hern?ndez PE, Nes IF.##Arlindo S, Calo P, Franco C, Prado M, Cepeda A, Barros-Vel?zquez J." "Biochemical and genetic characterization of enterocin P, a novel sec-dependent bacteriocin from Enterococcus faecium P13 with a broad antimicrobial spectrum.##Single nucleotide polymorphism analysis of the enterocin P structural gene of Enterococcus faecium strains isolated from nonfermented animal foods." DRAMP00089 TTKNYGNGVCNSVNWCQCGNVWASCNLATGCAAWLCKLA 39 Bacteriocin E50-52 (Preclinical) P85148 Belongs to the class IIa bacteriocin Not found Enterococcus faecium (Streptococcus faecium) (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Bacteriocin active against the Gram-negative bacteria and the Gram-positive bacteria. When added to the drinking water of chickens, causes a decrease in the levels of Campylobacter jejuni and S. enteritidis in the ceca, and in the levels of S.enteritidis in the liver and spleen." "Gram-negative bacteria: Campylobacter jejuni (MIC=0.025-6.4 ?g/ml), Yersinia enterocolitica, Yersinia pseudotuberculosis, Escherichia coli O157:H7 (MIC<1.6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=0.2-0.8 ?g/ml), Staphylococcus epidermidis (MIC=0.2-0.8 ?g/ml), Listeria monocytogenes (MIC=2-8 ?g/ml), Listeria grayi, Listeria innocua, Listeria ivanovii, Listeria denitrificans (MIC=32 ?g/ml), Morganella morganii, Salmonella spp., Shigella dysenteriae." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 18293921 J Agric Food Chem. 2008 Mar 26;56(6):1942-1948. "Svetoch EA, Eruslanov BV, Perelygin VV, Mitsevich EV, Mitsevich IP, Borzenkov VN, Levchuk VP, Svetoch OE, Kovalev YN, Stepanshin YG, Siragusa GR, Seal BS, Stern NJ." Diverse antimicrobial killing by Enterococcus faecium E 50-52 bacteriocin. DRAMP00090 VNYGNGVSCSKTKCSVNWGQAFQERYTAGINSFVSGVASGAGSIGRRP 48 Carnobacteriocin B2 (CbnB2; Bacteriocin) P38580 Belongs to the class IIa bacteriocin cbnB2 Carnobacterium piscicola LV18B (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix (1 helices; 24 residues) CbnB2 forms a disulfide bond and that this peptide has full antimicrobial activity. NMR results indicate that CbnB2 in TFE has a well-defined central helical structure (residues 18-39) but a disordered N terminus. And the central helical structure is conserved. 1CW5 resolved by NMR. "Function: Has antibacterial activity against Listeria and Enterococcus. PTM: Contains one disulfide bond 9-14." "[Ref.8163526]Gram-positive bacteria: Lactobacillus plantarum ATCC 4008 (MIC=2 AU/g), Pediococcus parvulus ATCC 19371 (MIC=8 AU/g), Listeria monocytogenes ATCC 15313 (MIC=32 AU/g), Listeria innocua ATCC 33090 (MIC=16 AU/g), Enterococcus faecium ATCC 11576 (MIC=16 AU/g), Enterococcus faecalis ATCC 19433 (MIC=16 AU/g), Enterococcus faecium ATCC 19434 (MIC=4 AU/g)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free [Ref.8163526 & Ref.10569926] CbnB2 can easily form a disulfide bond between Cys9 and Cys14 L No cytotoxicity information found Not found 8163526##9353214##10569926 J Biol Chem 1994; 269: 12204-12211.##Curr Microbiol. 1997 Dec;35(6):319-326.##Biochemistry. 1999 Nov 23;38(47):15438-15447. "Quadri LE et al Stiles ME.##Herbin S, Mathieu F, Brul? F, Branlant C, Lefebvre G, Lebrihi A.##Wang Y, Henz ME, Gallagher NL, Chai S, Gibbs AC, Yan LZ, Stiles ME, Wishart DS, Vederas JC." Chemical and genetic characterization of bacteriocins produced by Carnobacterium piscicola LV18B.##Characteristics and genetic determinants of bacteriocin activities produced by Carnobacterium piscicola CP5 isolated from cheese.##Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria. DRAMP00105 SNDSLWYGVGQFMGKQANCITNHPVKHMIIPGYCLSKILG 40 Enterocin X alpha (Two-peptide bacteriocin) No entry found Belongs to the class IIa bacteriocin enxA Enterococcus faecium KU-B5 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: EntXalpha and EntXbeta encode a double-glycine-type prepeptide with an 18-residue leader sequence, representing the typical structure of class II bacteriocin prepeptides. When combined, Xalpha and Xbeta display variably enhanced or reduced antibacterial activity toward a panel of indicators compared to each peptide individually. " "Gram-positive bacteria: Enterococcus faecalis JCM 5803 (MIC=50.8 nM), Enterococcus faecalis OU510 (MIC=102 nM), Enterococcus faecium TUA 1344L (MIC=50.8 nM), Enterococcus hirae ATCC 10541 (MIC=50.8 nM), Lactobacillus plantarum ATCC 14917 (MIC=102 nM), Lactobacillus sakeii ssp.sakei JCM 1157 (MIC=50.8 nM), Lactococcus lactis ssp.cremoris ATCC 19257 (MIC=813 nM), Listeria innocua ATCC 33090 (MIC=25.4 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 20418437 Appl Environ Microbiol. 2010 Jul;76(13):4542-4545. "Hu CB, Malaphan W, Zendo T, Nakayama J, Sonomoto K." "Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides." DRAMP00106 IAPIIVAGLGYLVKDAWDHSDQIISGFKKGWNGGRRK 37 Enterocin X beta (Two-peptide bacteriocin) No entry found Belongs to the class IIa bacteriocin enxB Enterococcus faecium KU-B5 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: EntXalpha and EntXbeta encode a double-glycine-type prepeptide with an 18-residue leader sequence, representing the typical structure of class II bacteriocin prepeptides. When combined, Xalpha and Xbeta display variably enhanced or reduced antibacterial activity toward a panel of indicators compared to each peptide individually. " "Gram-positive bacteria: Enterococcus faecalis JCM 5803 (MIC=813 nM), Enterococcus faecalis OU510 (MIC=813 nM), E. faecium TUA 1344L (MIC=813 nM), Enterococcus hirae ATCC 10541 (MIC=406 nM), Lactobacillus plantarum ATCC 14917 (MIC=813 nM), Lactobacillus sakeii ssp.sakei JCM 1157 (MIC=102 nM), Bacillus circulans JCM 2504 (MIC=3250 nM), Bacillus coagulans JCM 2257 (MIC=3250 nM), Bacillus subtilis JCM 1465 (MIC=3250 nM), Listeria innocua ATCC 33090 (MIC=3250 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 20418437 Appl Environ Microbiol. 2010 Jul;76(13):4542-4545. "Hu CB, Malaphan W, Zendo T, Nakayama J, Sonomoto K." "Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides." DRAMP00107 TNYGNGVGVPDAIMAGIIKLIFIFNIRQGYNFGKKAT 37 Bacteriocin L-1077 No entry found Belongs to the class IIa bacteriocin Not found Lactobacillus salivarius L-1077 (NRRL B-50053) (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Salmonella Enteritidis 1 (MIC=0.19 ug/ml), S. Enteritidis 4 (MIC=0.38 ug/ml), S. Enteritidis 204 (MIC=0.38 ug/ml), S. Enteritidis 237 (MIC=0.19 ug/ml), Salmonella Choleraesuis 434/4 (MIC=0.38 ug/ml), S. Choleraesuis 370 (MIC=0.19 ug/ml), Salmonella Typhimurium 483/6 (MIC=0.19 ug/ml), S. Typhimurium 44/8 (MIC=0.19 ug/ml), Salmonella Gallinarum-Pullorum (MIC=0.19 ug/ml), Escherichia coli HB 101 (MIC=0.19 ug/ml), E. coli-600 (MIC=0.19 ug/ml), E. coli O157:H7 Y-63 (MIC=0.19 ug/ml), E. coli O157:H7 G-35 (MIC=0.19 ug/ml), E. coli O157:H7 OD 30 (MIC=0.19 ug/ml), E. coli O157:H7 T lab 39 (MIC=0.19 ug/ml), Yersinia enterocolitica 03 (MIC=0.76 ug/ml), Y. enterocolitica 09 (MIC=0.76 ug/ml), Y. enterocolitica 11 (MIC=0.76 ug/ml), Citrobacter freundii (MIC=0.76 ug/ml), Klebsiella pneumoniae (MIC=0.76 ug/ml), Shigella dysenteriae (MIC=0.76 ug/ml), Yersinia pseudotuberculosis 4 (MIC=0.76 ug/ml), Y. pseudotuberculosis 99/14 (MIC=0.76 ?g/ml), Pseudomonas aeruginosa 508 (MIC=0.38 ug/ml), Proteus mirabilis (MIC=0.38 ug/ml), Morganella morganii (MIC=0.38 ?g/ml), Proteus vulgaris 7A (MIC=1.5 ug/ml),Campylobacter jejuni L-4 (MIC=0.09 ug/ml);##Gram-positive bacteria: Clostridium perfringens? 13124 (MIC=0.7 ug/ml), Listeria monocytogenes A 9-72 (MIC=0.19 ug/ml), Staphylococcus aureus (MIC=0.76 ug/ml), Staphylococcus epidermidis (MIC=0.76 ug/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 21378051 Appl Environ Microbiol. 2011 Apr;77(8):2749-2754. "Svetoch EA, Eruslanov BV, Levchuk VP, Perelygin VV, Mitsevich EV, Mitsevich IP, Stepanshin J, Dyatlov I, Seal BS, Stern NJ." "Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum." DRAMP00126 FNRGGYNFGKSVRHVVDAIGSVAGIRGILKSIR 33 Plantaricin E (PlnE; Bacteriocin) "P71470, Q7AKV7" Belongs to the class IIb bacteriocin plnE Lactobacillus plantarum (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix (3 helices; 19 residues) "In DPC micelles, PlnE has an N-terminal alpha-helix (residues 10-21), and a C-terminal alpha-helix-like structure (residues 25-31). Both helices in plnE are amphiphilic, while the helix in plnF is polar in its N-terminal half and amphiphilic in its C-terminal half. PlnE has two GxxxG motifs which are putative helix-helix interaction motifs, one at residues 5 to 9 and one at residues 20 to 24." 2JUI resolved by NMR. Comment: No comments found on DRAMP database "Gram-positive bacteria: Pediococcus pentosaceus Pac 1.0 (MIC=5 nM), Lactobacillus plantarum 965 (MIC=7 nM), Lactobacillus casei subsp.casei NCDO 161 (MIC=20 nM), Lactobacillus casei NCDO 2713 (MIC=150 nM), Lactobacillus sakei NCDO 2714 (MIC=4 nM), Lactobacillus viridescens NCDO 1655 (MIC=2 nM), Pediococcus pentosaceus NCDO 990 (MIC=30 nM), Lactobacillus sakei 706 (MIC=100 nM), Pediococcus acidilactici CH (MIC=10 nM), Lactobacillus curvatus 89 (MIC=5 nM). [PlnE:PlnF=1:1]" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free There is a possible hydrogen bond/salt bridge between Asp17 and Arg26 L No cytotoxicity information found Not found 8117074##18555030 Appl Environ Microbiol. 1994 Jan;60(1):160-166.##Biochim Biophys Acta. 2008 Nov;1784(11):1711-1719. "Diep DB, H?varstein LS, Nissen-Meyer J, Nes IF.##Fimland N, Rogne P, Fimland G, Nissen-Meyer J, Kristiansen P.E." "The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr-like regulatory system.##Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin plantaricin EF." DRAMP00127 VFHAYSARGVRNNYKSAVGPADWVISAVRGFIHG 34 Plantaricin F (PlnF; Bacteriocin) "P71469, Q7AKV8" Belongs to the class IIb bacteriocin plnF Lactobacillus plantarum (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix (1 helices; 26 residues) "In DPC micelles, PlnF has a long central alpha-helix (residues 7-32) with a kink of 38+/-7 degrees at Pro20. There is some flexibility in the helix in the kink region. The helix in plnF is polar in its N-terminal half and amphiphilic in its C-terminal half. plnF has one such motif at residues 30 to 34. The helix in plnF is polar in its N-terminal half and amphiphilic in its C-terminal half. PlnF has one GxxxG motif at residues 30 to 34." 2RLW resolved by NMR. "Function: A strain-specific antagonistic activity was detected at nanomolar concentrations when PlnE and PlnF were combined. Complementary peptides were at least 103 times more active when they were combined than when they were present individually, and optimal activity was obtained when the complementary peptides were present in approximately equal amounts." "Gram-positive bacteria: Pediococcus pentosaceus Pac 1.0 (MIC=5 nM), Lactobacillus plantarum 965 (MIC=7 nM), Lactobacillus casei subsp.casei NCDO 161 (MIC=20 nM), Lactobacillus casei NCDO 2713 (MIC=150 nM), Lactobacillus sakei NCDO 2714 (MIC=4 nM), Lactobacillus viridescens NCDO 1655 (MIC=2 nM), Pediococcus pentosaceus NCDO 990 (MIC=30 nM), Lactobacillus sakei 706 (MIC=100 nM), Pediococcus acidilactici CH (MIC=10 nM), Lactobacillus curvatus 89 (MIC=5 nM). [PlnE:PlnF=1:1]" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free There is a possible hydrogen bond/salt bridge between Asn12/Asn13 and Asp22 L No cytotoxicity information found Not found 9603847##19538999##18555030 Appl Environ Microbiol. 1994 Jan;60(1):160-166.##Appl Environ Microbiol. 1998 Jun;64(6):2269-2272.## "Diep DB, H?varstein LS, Nissen-Meyer J, Nes IF.##Anderssen EL, Diep DB, Nes IF, Eijsink VG, Nissen-Meyer J.##Fimland N, Rogne P, Fimland G, Nissen-Meyer J, Kristiansen P.E." "The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr-like regulatory system.##Antagonistic activity of Lactobacillus plantarum C11: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A.##Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin plantaricin EF." DRAMP00128 GAWKNFWSSLRKGFYDGEAGRAIRR 25 Plantaricin J (PlnJ; Bacteriocin) "P71461, Q7AKW6" Belongs to the class IIb bacteriocin plnJ Lactobacillus plantarum C11 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix "In DPC micelles, PlnJ has an N-terminal amphiphilic alpha-helix between Trp-3 and Tyr-15. Crucial residues: Gly-13 in PlnJ is very sensitive, giving more than a 100-fold reduction in activity when large residues replace glycine. Gly-20 in PlnJ was replaced, the activity was reduced less than 10-fold." "2KHF, 2KHG resolved by NMR." Function: A 1:1 ratio of PlnK and PlanJ is at least 1000 times more active than the individual peptide. "Gram-positive bacteria: Pediococcus pentosaceus Pac 1.0 (MIC=50 nM), Lactobacillus plantarum 965 (MIC=0.1 nM), L. sake NCDO 2714 (MIC=50 nM), Leptostylus viridescens NCDO 1655 (MIC=5 nM). [PlnJ:PlnK=1:1]" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 9603847##19538999 Appl Environ Microbiol. 1998 Jun;64(6):2269-2272.##Peptides. 2009 Sep;30(9):1613-1621. "Anderssen EL, Diep DB, Nes IF, Eijsink VG, Nissen-Meyer J.##Rogne P, Haugen C, Fimland G, Nissen-Meyer J, Kristiansen PE." "Antagonistic activity of Lactobacillus plantarum C11: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A.##Three-dimensional structure of the two-peptide bacteriocin plantaricin JK." DRAMP00129 RRSRKNGIGYAIGYAFGAVERAVLGGSRDYNK 32 Plantaricin K (PlnK; Bacteriocin) P71460 Belongs to the class IIb bacteriocin plnK Lactobacillus plantarum C11 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix "In DPC micelles, PlnK forms a central amphiphilic alpha-helix between Gly-9 and Leu-24. Crucial residues: Gly-17 in PlnK is very sensitive, giving more than a 100-fold reduction in activity when large residues replace glycine. Gly-7, Gly-9, Gly-24 and Gly-25 in PlnK were replaced, the activity was reduced less than 10-fold." "2KEG, 2KEH resolved by NMR." Function: A 1:1 ratio of PlnK and PlanJ is at least 1000 times more active than the individual peptide. "Gram-positive bacteria: Pediococcus pentosaceus Pac 1.0 (MIC=50 nM), Lactobacillus plantarum 965 (MIC=0.1 nM), L. sake NCDO 2714 (MIC=50 nM), Leptostylus viridescens NCDO 1655 (MIC=5 nM). [PlnJ:PlnK=1:1]" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 9603847##19538999 Appl Environ Microbiol. 1998 Jun;64(6):2269-2272.##Peptides. 2009 Sep;30(9):1613-1621. "Anderssen EL, Diep DB, Nes IF, Eijsink VG, Nissen-Meyer J.##Rogne P, Haugen C, Fimland G, Nissen-Meyer J, Kristiansen PE." "Antagonistic activity of Lactobacillus plantarum C11: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A.##Three-dimensional structure of the two-peptide bacteriocin plantaricin JK." DRAMP00136 NRWYCNSAAGGVGGAAVCGLAGYVGEAKENIAGEVRKGWGMAGGFTHNKACKSFPGSGWASG 62 Enterocin E-760 (Bacteriocin) P85147 Belongs to the class IIb bacteriocin Not found Enterococcus sp. (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: The enterocin demonstrated thermostability by retaining activity after 5 min at 100 degrees C and was stable at pH values between 5.0 and 8.7. However, activity was lost below pH 3.0 and above pH 9.5. No hemolytic activity." "[Ref.18086839]Gram-positive bacteria: Listeria monocytogenes 9-72 (MIC=0.1 g/ml), Staphylococcus epidermidis (MIC=1.6 g/ml), S. aureus (MIC=1.6 g/ml);##Gram-negative bacteria: S. enterica serovar Enteritidis 1 (MIC=0.2 g/ml), S. enterica serovar Enteritidis 4 (MIC=0.4 g/ml), S. enterica serovar Enteritidis 204 (MIC=0.2 g/ml), S. enterica serovar Enteritidis 237 (MIC=0.2 g/ml), S. enterica serovar Choleraesuis 434/4 (MIC=0.4 g/ml), S. enterica serovar Choleraesuis 370 (MIC=0.4 g/ml), S. enterica serovar Typhimurium 383/60 (MIC=0.4 g/ml), S. enterica serovar Typhimurium 320 (MIC=0.2 g/ml), S. enterica serovar Gallinarum biovar Pullorum (MIC=0.4 g/ml), Escherichia coli HB101 (MIC=0.1 g/ml), E. coli C600 (MIC=0.1 g/ml), E. coli O157:H7 Y-63 (MIC=1.6 g/ml), E. coli O157:H7 G-3 (MIC=1.6 g/ml), E. coli O157:H7 OD-3 (MIC=1.6 g/ml), E. coli O157:H7 T-39 (MIC=1.6 g/ml), Yersinia enterocolitica 03 (MIC=0.1 g/ml), Y. enterocolitica 09 (MIC=0.1 g/ml), Y. enterocolitica 04 (MIC=0.1 g/ml), Y. pseudotuberculosis ser 4 (MIC=3.2 g/ml), Y. pseudotuberculosis 14 (MIC=3.2 g/ml), Citrobacter freundii (MIC=1.6 g/ml), Klebsiella pneumoniae (MIC=3.2 g/ml), Shigella dysenteriae (MIC=0.1 g/ml), Campylobacter jejuni L4 (MIC=0.1 g/ml), Campylobacter P 1-R (MIC=0.2 g/ml), Campylobacter P-45 (MIC=0.4 g/ml), Campylobacter lari R (MIC=0.2 g/ml), Campylobacter LB 6-R (MIC=0.1 g/ml), Campylobacter C/D (MIC=0.2 g/ml),." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 18086839 Antimicrob Agents Chemother. 2008 Mar;52(3):1094-1100. "Line JE, Svetoch EA, Eruslanov BV, Perelygin VV, Mitsevich EV, Mitsevich IP, Levchuk VP, Svetoch OE, Seal BS, Siragusa GR, Stern NJ." Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and Gram-negative bacteria. DRAMP00171 LIDHLGAPRWAVDTILGAIAVGNLASWVLALVPGPGWAVKAGLATAAAIVKHQGKAAAAAW 61 Lactocyclicin Q (Bacteriocin) B9ZZY0 Belongs to the class IIc bacteriocin lycQ Lactococcus sp. strain QU 12 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Lactococcus sp.strain QU 12 (MIC=34.3 ?M), Lactococcus lactis subsp.lactis JCM 7638 (MIC=0.141 ?M), L. lactis subsp.lactis ATCC 19435 (MIC=0.141 ?M), L. lactis subsp.lactis IL1403 (MIC=0.141 ?M), L. lactis QU 1 (MIC=0.141 ?M), L. lactis subsp.cremoris ATCC 19275 (MIC=0.283 ?M), Lactococcus raffinolactis JCM 5706 (MIC=0.71 ?M), Lactobacillus sakei subsp.sakei JCM 1157 (MIC=0.015 ?M), Lactobacillus casei subsp.casei JCM 1134 (MIC=2.27 ?M), Leuconostoc brevis JCM 1059 (MIC=1.14 ?M), L. acidophilus JCM 1132 (MIC=2.86 ?M), L. coryniformis subsp.coryniformis JCM 1164 (MIC=2.86 ?M), L. kimchii JCM 10707 (MIC=0.71 ?M), L. mesenteroides subsp.mesenteroides JCM 6124 (MIC=1.03 ?M), Weissella cibaria JCM 12495 (MIC=0.71 ?M), Pediococcus pentosaceus JCM 5885 (MIC=0.55 ?M), P. pentosaceus JCM 5890 (MIC=2.86 ?M), P. acidilactici JCM 8797 (MIC=2.86 ?M), P. dextrinicus JCM 5887 (MIC=0.141 ?M), Enterococcus faecium JCM5804 (MIC=0.71 ?M), E. hirae ATCC 10541 (MIC=0.71 ?M), E. durans NBRC 100479 (MIC=0.71 ?M), E. faecalis JCM 5803 (MIC=0.26 ?M), Streptococcus salivarius JCM 5707 (MIC=22.9 ?M), S. bovis JCM 5802 (MIC=22.9 ?M), Bacillus coagulans JCM 2257 (MIC=0.015 ?M), B. circulans JCM 2504 (MIC=0.031 ?M), B. subtilis JCM 1465 (MIC=0.064 ?M), B. cereus JCM 2152 (MIC=11.4 ?M), Micrococcus luteus IFO 12708 (MIC=5.7 ?M), Listeria innocua ATCC 33090 (MIC=1.03 ?M), L. monocytogenes ATCC BAA-679 (MIC=1.03 ?M), Staphylococcus aureus subsp.aureus ATCC 12600 (MIC=91.6 ?M); Gram-negative bacteria: Escherichia coli JM109 (MIC=34.3 ?M), E. coli NBRC 3301 (MIC=17.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) The whole peptide has a cyclic structure in which N and C termini are bound to each other. L No cytotoxicity information found Not found 19139222##21948835 Appl Environ Microbiol. 2009 Mar;75(6):1552-1558.##Appl Environ Microbiol. 2011 Nov;77(22):8164-8170. "Sawa N, Zendo T, Kiyofuji J, Fujita K, Himeno K, Nakayama J, Sonomoto K.##Masuda Y, Ono H, Kitagawa H, Ito H, Mu F, Sawa N, Zendo T, Sonomoto K." "Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus sp. strain QU 12.##Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401." DRAMP00173 LVNQLGISKSLANTILGAIAVGNLASWVLALVPGPGWATKAALATAETIVKHEGKAAAIAW 61 Leucocyclicin Q (Bacteriocin) G5ELQ0 Belongs to the class IIc bacteriocin lcyQ Leuconostoc mesenteroides TK41401 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Predicted Not found Not found None "Function: This precursor showed high similarity to the precursor of lactocyclicin Q, a cyclic bacteriocin produced by Lactococcus sp. strain QU 12. This is the first report of a cyclic bacteriocin produced by a strain of the genus Leuconostoc." "Gram-positive bacteria: Lactococcus lactis ssp. lactis JCM 7638 (MIC=0.038 ?M), L. lactis ssp. lactis ATCC 19435 (MIC=0.038 ?M), L. sp. QU 12 (MIC=1.203 ?M), Lactobacillus sakei ssp. sakei JCM 1157 (MIC=0.038 ?M), Weissella cibaria JCM 12495 (MIC=2.405 ?M), W. paramesenteroides JCM 9890 (MIC=0.075 ?M), Pediococcus pentosaceus JCM 5885 (MIC=2.405 ?M), P. dextrinicus JCM 5887 (MIC=0.038 ?M), Enterococcus faecium JCM 5804 (MIC=0.038 ?M), E. faecalis JCM 5803 (MIC=0.15 ?M), Streptococcus salivarius JCM 5707 (MIC=2.405 ?M), S. bovis JCM 5802 (MIC=0.601 ?M), S. mutans JCM 5705 (MIC=19.25 ?M), Bacillus coagulans JCM 2257 (MIC=0.075 ?M), B. subtilis ssp. subtilis JCM 1465 (MIC=0.601 ?M), B. cereus JCM 2152 (MIC=2.405 ?M), Kocuria rhizophila NBRC 12708 (MIC=9.623 ?M), Listeria innocua ATCC 33090 (MIC=0.601 ?M), Leuconostoc mesenteroides ssp. mes. JCM 6124 (MIC=0.3 ?M), Escherichia coli JM109 (MIC=38.49 ?M), E. coli NBRC 3301 (MIC=38.49 ?M)" No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) The whole peptide has a cyclic structure in which N and C termini are bound to each other. L No cytotoxicity information found Not found 21948835 Appl Environ Microbiol. 2011 Nov;77(22):8164-8170. "Masuda Y, Ono H, Kitagawa H, Ito H, Mu F, Sawa N, Zendo T, Sonomoto K." "Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401." DRAMP00177 ENDHRMPNNLNRPNNLSKGGAKCGAAIAGGLFGIPKGPLAWAAGLANVYSKCN 53 Enterocin B (EntB; Bacteriocin) O34017 Belongs to the class IId bacteriocin entB Enterococcus faecium T136 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Enterococcus faecalis JCM 5803 (MIC=86.9 nM), Enterococcus faecalis OU510 (MIC=174 nM), E. faecium TUA 1344L (MIC=43.4 nM), E. hirae ATCC 10541 (MIC=5.44 nM), Lactobacillus plantarum ATCC 14917 (MIC=86.9 nM), L. sakei ssp. sakei JCM 1157 (MIC=5.44 nM), Bacillus coagulans JCM 2257 (MIC=89000 nM), Bacillus subtilis JCM 1465 (MIC=44500 nM)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free The peptide has forms a disulfide bond between Cys-23 and Cys-52 L No cytotoxicity information found Not found 10224016##9245817 Appl Environ Microbiol. 1999 May;65(5):2170-2178.##Microbiology. 1997 Jul;143 (Pt 7):2287-2294. "Franz CM, Worobo RW, Quadri LE, Schillinger U, Holzapfel WH, Vederas JC, Stiles ME.##Casaus P, Nilsen T, Cintas LM, Nes IF, Hern?ndez PE, Holo H." "Atypical genetic locus associated with constitutive production of enterocin B by Enterococcus faecium BFE 900.##Enterocin B, a new bacteriocin from Enterococcus faecium T136 which can act synergistically with enterocin A." DRAMP00178 MLAKIKAMIKKFPNPYTLAAKLTTYEINWYKQQYGRYPWERPVA 44 Enterocin EJ97 (EntEJ97; Bacteriocin) Q8KMU4 Belongs to the class IId bacteriocin ej97a Enterococcus faecalis EJ97 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus circulans (MIC=12 ?g/ml), Bacillus coagulans CECT 12 (MIC=2 ?g/ml), Bacillus megaterium (MIC=4 ?g/ml), Bacillus stearothermophilus CECT 49 (MIC=14 ?g/ml), Bacillus stearothermophilus CECT 148 (MIC=12 ?g/ml), Bacillus subtilis (MIC=12 ?g/ml), Paenibacillus macerans CECT 19 (MIC=4 ?g/ml), Enterococcus faecalis ssp.faecalis S-13 (MIC=6 ?g/ml), E. faecalis ssp.faecalis S-14 (MIC=8 ?g/ml), E. faecalis ssp.faecalis S-32 (MIC=12 ?g/ml), E. faecalis ssp.faecalis S-86 (MIC=8 ?g/ml), E. faecalis ssp.liquefaciens S-39 (MIC=6 ?g/ml), E. faecalis ssp.liquefaciens S-40 (MIC=8 ?g/ml), E. faecalis ssp. liquefaciens S-47 (MIC=12 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 12620853##20385607##9871020 Appl Environ Microbiol. 2003 Mar;69(3):1633-1641.##Protein Eng Des Sel. 2010 Jul;23(7):507-518.##Arch Microbiol. 1998 Dec;171(1):59-65. "S?nchez-Hidalgo M, Maqueda M, G?lvez A, Abriouel H, Valdivia E, Mart?nez-Bueno M.##Neira JL, Contreras LM, de los Paos OR, S?nchez-Hidalgo M, Mart?nez-Bueno M, Maqueda M, Rico M.##G?lvez A, Valdivia E, Abriouel H, Camafeita E, Mendez E, Mart?nez-Bueno M, Maqueda M." "The genes coding for enterocin EJ97 production by Enterococcus faecalis EJ97 are located on a conjugative plasmid.##Structural characterisation of the natively unfolded enterocin EJ97.##Isolation and characterization of enterocin EJ97, a bacteriocin produced by Enterococcus faecalis EJ97." DRAMP00189 KGLGKLIGIDWLLGQAKDAVKQYKKDYKRWH 31 Leucocin Q (Bacteriocin) No entry found Belongs to the class IId bacteriocin LccQ Leuconostoc pseudomesenteroides QU 15 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: Leuc.pseudomesenteroides QU 15 (isolated from Nukadoko) produce at least three bacteriocins, leucocin A, and two novel bacteriocins termed leucocin Q and leucocin " "Gram-positive bacteria: Bacillus circulans JCM 2504T (MIC=4.10 ?mol/L), Listeria innocua ATCC 33090 (MIC=0.03 ?mol/L), Listeria monocytogenes ATCC BAA-679 (MIC=1.03 ?mol/L), Enterococcus faecalis JCM 5803 (MIC=4.10 ?mol/L), Lactobacillus plantarum ATCC 14917 (MIC=4.10 ?mol/L), Lactobacillus sakei ssp. sakei JCM 1157 (MIC=1.04 ?mol/L), Leuconostoc mesenteroides ssp. mesenteroides JCM 6124 (MIC=4.10 ?mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 20070442 J Appl Microbiol. 2010 Jul;109(1):282-291. "Sawa N, Okamura K, Zendo T, Himeno K, Nakayama J, Sonomoto K." Identification and characterization of novel multiple bacteriocins produced by Leuconostoc pseudomesenteroides QU 15. DRAMP00190 MNKEYNSISNFKKITNKDLQNINGGFIGRAIGDFVYFGAKGLRESGKLLNYYYKHKH 57 Leucocin N (Bacteriocin) No entry found Belongs to the class IId bacteriocin LccN Leuconostoc pseudomesenteroides QU 15 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: Leuc.pseudomesenteroides QU 15 (isolated from Nukadoko) produce at least three bacteriocins, leucocin A, and two novel bacteriocins termed leucocin Q and leucocin N." "Gram-positive bacteria: Bacillus circulans JCM 2504T (MIC=5.20 ?mol/L), Listeria innocua ATCC 33090 (MIC=1.30 ?mol/L), Listeria monocytogenes ATCC BAA-679 (MIC=1.30 ?mol/L), Enterococcus faecalis JCM 5803 (MIC=5.20 ?mol/L), Lactobacillus plantarum ATCC 14917 (MIC=2.60 ?mol/L), Lactobacillus sakei ssp.?sakei?JCM 1157 (MIC=1.30 ?mol/L), Leuconostoc mesenteroides ssp. mesenteroides JCM 6124 (MIC=2.60 ?mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 20070442 J Appl Microbiol. 2010 Jul;109(1):282-291. "Sawa N, Okamura K, Zendo T, Himeno K, Nakayama J, Sonomoto K." Identification and characterization of novel multiple bacteriocins produced by Leuconostoc pseudomesenteroides QU 15. DRAMP00191 GGAGHVPEYFVGIGTPISFYG 21 Microcin J25 (MccJ25; Bacteriocin) Q9X2V7 Belongs to the class I microcin mcjA Escherichia coli AY25 (Gram-negative bacteria) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Beta strand "MccJ25 does not have a head-to-tail cyclic structure but rather a side chain to backbone cyclization between Glu8 and the N-terminus. This creates an embedded ring that is threaded by the C-terminal tail of the molecule, forming a noose-like feature. The three-dimensional structure deduced from NMR data suggests that slippage of the noose is prevented by two aromatic residues flanking the embedded ring." "1Q71, 1PP5 resolved by NMR." "Function: Microcin J25 is a 21 amino acid bacterial peptide that has potent antibacterial activity against Gram-negative bacteria, resulting from its interaction with RNA polymerase. Induction: At the onset of stationary growth phase. PTM: Isoglutamyl glycine isopeptide between G1 and E8." "Gram-negative bacteria: Escherichia coli BM21 (MIC=0.08 ?g/ml), E. coli AB1133 (MIC=0.02 ?g/ml), E. coli RYC816 (MIC=0.04 ?g/ml), E. coli AY29 (MIC=0.04 ?g/ml), Salmonella species, Shigella flexneri." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization of a N-terminal between Gly and Glu Free None L No cytotoxicity information found Not found 1429464##10092860##14531690##14531661 J Bacteriol. 1992 Nov;174(22):7428-7435.##Eur J Biochem. 1999 Feb;259(3):747-755.##J Am Chem Soc. 2003 Oct 15;125(41):12464-74.##J Am Chem Soc. 2003 Oct 15;125(41):12382-3. "Salom?n RA, Far?as RN.##Blond A, P?duzzi J, Goulard C, Chiuchiolo MJ, Barth?l?my M, Prigent Y, Salom?n RA, Far?as RN, Moreno F, Rebuffat S.##Rosengren KJ, Clark RJ, Daly NL, G?ransson U, Jones A, Craik DJ.##Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH." "Microcin 25, a novel antimicrobial peptide produced by Escherichia coli.##The cyclic structure of microcin J25, a 21-residue peptide antibiotic from Escherichia coli.##Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone.##Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot." DRAMP00201 SCNCVCGVCCSCSP 14 Amythiamicin A/B (Bacteriocin) P0C912 Belongs to the thiocillin family Not found Amycolatopsis sp. (strain MI481-42F4 / FERM P-12739) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Has bacteriocidal activity against Gram-positive bacteria: including multi-drug resistant strains such as Staphylococcus aureus MS9610 and Methicillin-resistant S.aureus, but is not active against most Gram-negative bacteria and fungi. PTM: Maturation of thiazole and oxazole containing antibiotics involves the enzymic condensation of a Cys, Ser or Thr with the alpha-carbonyl of the preceding amino acid to form a thioether or ether bond, then dehydration to form a double bond with the alpha-amino nitrogen. Thiazoline or oxazoline rings are dehydrogenated to form thiazole or oxazole rings. Maturation of pyridinyl containing antibiotics involves the cross-linking of a Ser and a Cys-Ser pair usually separated by 7 or 8 residues along the peptide chain. The Ser residues are dehydrated to didehydroalanines, then bonded between their beta carbons. The alpha carbonyl of the Cys condenses with the alpha carbon of the first Ser to form a pyridinyl ring. The ring may be multiply dehydrogenated to form a pyridine ring with loss of the amino nitrogen of the first Ser. The diketopiperazine ester in form C may be formed by cyclization and transesterification of the C-terminal dipeptide." "Gram-positive bacteria: Staphylococcus aureus MS9610 (MIC=0.2 ?g/ml), Methicillin-resistant S. aureus (MIC=0.2 ?g/ml), Staphylococcus aureus FDA209P (MIC=0.1 ?g/ml), Micrococcus luteus FDA16 (MIC=0.1 ?g/ml), M. luteus IFO3333 (MIC=0.78 ?g/ml), M. luteus PCI1001 (MIC=0.2 ?g/ml), Bacillus anthracis (MIC=0.1 ?g/ml), B. subtilis NRRL B-558 (MIC=0.2 ?g/ml), B. subtilis PCI219 (MIC=0.2 ?g/ml), B. cereus ATCC 10702 (MIC=0.1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8040071 J Antibiot (Tokyo). 1994 Jun;47(6):668-674. "Shimanaka K, Kinoshita N, Iinuma H, Hamada M, Takeuchi T." "Novel antibiotics, amythiamicins. I. Taxonomy, fermentation, isolation, physico-chemical properties, and antimicrobial activity." DRAMP00204 STNCFCYICCSCSS 14 Thiocillin GE37468 (Antibiotic GE37468; Bacteriocin) "P0C8P9, G1ECL0" Belongs to the thiocillin family getA Streptomyces sp. (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Has bacteriocidal activity against both aerobic and anaerobic Gram-positive bacteria. Has poor activity against Gram-negative bacteria, with the exception of B.fragilis. Inhibits bacterial protein biosynthesis by acting on elongation factor Tu (" "Gram-positive bacteria: Bacillus subtilis (MIC=0.047 ?g/ml), Staphylococcus aureus (MRSA) (MIC=0.047 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization Free "GE37468 has a macrocyclic ring composed of 10 residues (Ser1 to Cys10). Cys6 converts to a thiazoline while four other Cys residues (Cys4, Cys9, Cys10 and Cys12) are fully desaturated to thiazoles in GE37468. Ile8 converts to -methyl--hydroxy-proline(mhP) through a predicted tandem double hydroxylation/cyclization mechanism." L No cytotoxicity information found Not found 21788474 Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13053-13058. "Young TS, Walsh CT." Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans. DRAMP00218 RCTCTTIISSSSTF 14 Plantazolicin (PZN; Bacteriocin) "D3VML5, B3A0N7" Not found pznA Bacillus amyloliquefaciens FZB42 & Bacillus pumilus (Bacillus mesentericus) (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None Function: Peptide antibiotic inhibiting growth of Gram-positive bacteria: in the dimethylated form plantazolicin A. The desmethyl form plantazolicin B has no antibiotic activity. The mode of action appears to be disruption of cell walls and lysis of cells. Has antibacterial activity. "Gram-positive bacteria: Bacillus subtilis HB0042, Bacillus subtilis strain 168, Bacillus megaterium 7A1, Bacillus anthracis (MIC=2-4 ?g/ml), Bacillus brevis strain ATCC 8246, Bacillus cereus strain ATCC 14579 and strain CU1065, Bacillus licheniformis strain ATCC 9789, Micrococcus luteus, Bacillus sphaericus, Paenibacillus granivorans and Streptococcus pyogenes (MIC=128 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic (possibly) Free Free "10 residues (Cys, Ser/Thr) potentially serve as a site of heterocycle formation" L No cytotoxicity information found Not found 20971906 J Bacteriol. 2011 Jan;193(1):215-224. "Scholz R, Molohon KJ, Nachtigall J, Vater J, Markley AL, S?ssmuth RD, Mitchell DA, Borriss R." "Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42." DRAMP00222 GETDPNTQLLNDLGNNMAWGAALGAPGGLGSAALGAAGGALQTVGQGLIDHGPVNVFIPVLIGPSWNGSGSGYNSATSSSGSGS 84 Microcin E492 (MccE492; Bacteriocin) Q9Z4N4 Not found mceA Klebsiella pneumoniae RYC492 (Gram-negative bacteria) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Channel-forming bacteriocin. Forms cation-selective channels. Active on enterobacteria, with highest activity against Escherichia coli. The unmodified protein is active against Escherichia coli and S. enteritidis. When the siderophore ester is present at Ser-99, antibacterial activity against these species is increased and activity is also detected against E. cloacae and K. pneumoniae. PTM: The C-terminal Ser is modified by attachment to a siderophore similar to enterobactin, which can bind one atom of iron. The modification consists of an ester linkage of the serine carboxyl to O6 of a glucose which is linked by a C-glycosidic bond to the 5'-benzoyl of a linear triester of N-(2,3-dihydroxybenzoyl)serine. Presence of the siderophore ester increases the antibacterial activity of the protein." "Gram-negative bacteria: Escherichia coli F (MIC=0.14 ?M), Escherichia coli 363 (MIC=0.02 ?M), Escherichia coli ML35p (MIC=0.14 ?M), Escherichia coli GM1 (MIC=0.04 ?M), Escherichia coli GM1 KP1060(MIC=0.65 ?M), Escherichia coli W3110 (MIC=0.02 ?M), Escherichia coli W3110-KP1344 Pms7 (MIC=0.08 ?M), Escherichia coli W3110-6 (MIC=0.32 ?M), Escherichia coli C600 (MIC=0.08 ?M), Escherichia coli C600 pHX405 (MIC=0.16 ?M), Salmonella enteritidis (MIC=0.6 ?M), Salmonella typhimurium (MIC=1.2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Attachment to a siderophore ester "[Ref.15102848] The post-translational modification consists of a trimer of N-(2,3-dihydroxybnenzoyl)-L-serine linked via a C-glycosidic linkage to a -D-glucose moiety, itself linked to the MccE492m Ser-84-carboxyl through an O-glycosidic bond." L No cytotoxicity information found Not found 12890026##15102848##7682973 Mol Microbiol. 2003 Aug;49(4):1031-1041.##J Biol Chem. 2004 Jul 2;279(27):28233-28242.##FEBS Lett. 1993 Apr 26;321(2-3):145-148. "Destoumieux-Garz?n D, Thomas X, Santamaria M, Goulard C, Barth?l?my M, Boscher B, Bessin Y, Molle G, Pons AM, Letellier L, Peduzzi J, Rebuffat S.##Thomas X, Destoumieux-Garz?n D, Peduzzi J, Afonso C, Blond A, Birlirakis N, Goulard C, Dubost L, Thai R, Tabet JC, Rebuffat S.##Lagos R, Wilkens M, Vergara C, Cecchi X, Monasterio O." "Microcin E492 antibacterial activity: evidence for a TonB-dependent inner membrane permeabilization on Escherichia coli.##Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity.##Microcin E492 forms ion channels in phospholipid bilayer membrane." DRAMP00232 ATPATPTVAQFVIQGSTICLVC 22 Cypemycin (Bacteriocin) E5KIB6 Belongs to the linaridin family cypA Streptomyces sp. OH-4156 (Gram-positive bacteria) "Antimicrobial, Antibacterial" Protein level Not found Not found None Function: Antibiotic peptide structurally related to lantibiotics. Has cytotoxic activity against mouse P388 leukemia cells (IC50=1.3 g/ml). Micrococcus luteus (MIC=0.2 ?g/ml) No hemolysis information or data found in the reference(s) presented in this entry Cyclic [Ref. 10.1016/S0040-4039(00)78407-3] Dimethylation on Ala1 [Ref. 10.1016/S0040-4039(00)78407-3] Decarboxylation and Cyclization on D-Cys64 "[Ref. 10.1016/S0040-4039(00)78407-3] Thr2, Thr5, Thr7 and Thr17 converts to (E)-2,3-didehydrobutyrine. Ile13 and Ile18 converts to L-allo-isoleucine. Maturation involves the enzymatic conversion of Cys-19 into 2,3-didehydroalanine followed by formation of a thioether bond with Cys-22. The C-terminal meso-lanthionine then undergoes decarboxylation." [Ref. 10.1016/S0040-4039(00)78407-3] Mixed (D-Cys19) [Ref.7802859] IC50 = 1.3 g/mL against P388 leukemia cells in vitro. Not found 7802859##Pubmed ID is not available J Antibiot (Tokyo). 1993 Nov;46(11):1666-1671.##Tetrahedron Lett. 1994 Oct;35(43):8001-8004. "Komiyama K, Otoguro K, Segawa T, Shiomi K, Yang H, Takahashi Y, Hayashi M, Otani T, Omura S.##Minami Y, Yoshida K, Azuma R, Urakawa A, Kawauchi T, Otani T, Komiyama K, Omura S" "A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics. ##STRUCTURE OF CYPEMYCIN, A NEW PEPTIDE ANTIBIOTIC." DRAMP00244 XTPATPFTPAITEITAAVIAX 21 Hominicin (Bacteriocin) No entry found Not found Not found Staphylococcus hominis MBBL 2-9 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Hominicin exhibited heat stability up to 121 degrees C for 15min and activity under both acidic and basic conditions (from pH 2.0 to 10.0). "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=0.06 ?g/ml), S. aureus ATCC (MRSA) 11435 (MIC=0.96 ?g/ml), S. aureus (vancomycin-intermediate VISA) CCARM 3501 (MIC=3.82 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Dimethylation on Ile1 Free "The residue X at position 1 is DmIle (N1, N1-dimethyl-isoleucine).The residues T at position 2, 5, 8 and 15 are dehydrobutyrine. The residue at position 21 is a distinct residue Dmp (N2, N2-dimethyl-1,2-propanediamine) rarely found from biosynthetic antimicrobial peptides." L No cytotoxicity information found Not found 20654578 Biochem Biophys Res Commun. 2010 Aug 20;399(2):133-138. "Kim PI, Sohng JK, Sung C, Joo HS, Kim EM, Yamaguchi T, Park D, Kim BG." "Characterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2-9." DRAMP00254 WFYQGMNIAIYANIGGVANIIGYTEAAVATLLGAVVAVAPVVP 43 Propionicin-F (Bacteriocin) Q6E3K9 Not found pcfA Propionibacterium freudenreichii subsp. Freudenreichii LMGT 2946 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None Function: Bacteriocin with specific antibacterial activity. "Gram-positive bacteria: Propionibacterium freudenreichii ssp. freudenreichii ATCC 6207T (MIC=0.7 nM), P. freudenreichii ssp.shermanii ATCC 9614T (MIC=5.0 nM), P. freudenreichii ATCC 9616 (MIC=20 nM), P. freudenreichii IFO12426 (MIC=2.5 nM), P. freudenreichii LMGT 2842 (MIC=5.0 nM), P. freudenreichii LMGT 3001 (MIC=5.0 nM), P. freudenreichii LMGT 2946, P. freudenreichii LMGT 2956, P. freudenreichii ISU-P24 (MIC=0.7 nM), P. freudenreichii ISU-P59 (MIC=2.5 nM), P. freudenreichii ISU-P83 (MIC=5.0 nM), P. freudenreichii ISU-P98 (MIC=1.3 nM), P. freudenreichii ISU-P104 (MIC=0.2 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 15574930 Appl Environ Microbiol. 2004 Dec;70(12):7303-7310. "Brede DA, Faye T, Johnsborg O, Odeg?rd I, Nes IF, Holo H." "Molecular and genetic characterization of propionicin F, a bacteriocin from Propionibacterium freudenreichii." DRAMP00275 GSSFCDSKCKLRCSKAGLADRCLKYCGICCEECKCVPSGTYGNKHECPCYRDKKNSKGKSKCP 63 Snakin-1 (StSN1; Cys-rich; Plant defensin) Q948Z4 Not found SN1 Solanum tuberosum (potato) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None "Function: Has an antimicrobial activity. Causes a rapid aggregation of both Gram-positive and Gram-negative bacteria, but the antimicrobial activity is not correlated with the capacity to aggregate bacteria. Tissue specificity: Expressed in tubers, stems, axillary and young floral buds, sepals, petals, stamens and carpels, but not in roots, stolons, shoot apex meristem or young leaves. Induction: No responses to methyl jasmonate, ethylene, abscisic acid, salicylic acid, isonicotinic acid, indolacetic acid, gibberellic acid and infection with incompatible bacterial or compatible fungual pathogens. PTM: Six disulfide bonds may be present." "[Ref.9885189] Gram-positive bacteria: Listeria monocytogenes (MIC=10 ?g/mL), Listeria innocua (MIC=10 ?g/mL), Listeria ivanovii (MIC=10 ?g/mL), Clavibacter michiganensis (EC50=1 ?M), Ralstonia solanacearum (rfa-) (EC50=30 ?M), Rhizobium meliloti (EC50=8 ?M).##Fungi: Botrytis cinerea (EC50=2 ?M), Fusarium solani (EC50=3 ?M), Fusarium culmorum (EC50=2 ?M), Fusarium oxysporum f. sp. conglutinans (EC50=10 ?M), Fusarium oxysporum f. sp. lycopersici (EC50=20 ?M), Plectosphaerella cucumerina (EC50=10 ?M), Colletotrichum graminicola (EC50=10 ?M), Colletotrichum lagenarium (EC50=10 ?M), Bipolaris maydis (EC50=20 ?M), Aspergillus flavus (EC50=20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free [Ref.9885189] Six disulfide bonds may be present L No cytotoxicity information found Not found 11891250##9885189 Plant Physiol. 2002 Mar;128(3):951-961.##Mol Plant Microbe Interact. 1999 Jan;12(1):16-23. "Marta Berrocal-Lobo, Ana Segura, Manuel Moreno, Gemma Lpez, Francisco Garca-Olmedo, Antonio Molina##A Segura, M Moreno, F Madue?o, A Molina, F Garca-Olmedo" "Snakin-2, an antimicrobial peptide from potato whose gene is locally induced by wounding and responds to pathogen infection.##Snakin-1, a peptide from potato that is active against plant pathogens." DRAMP00336 IPCGESCVWIPCITAIAGCSCKNKVCYT 28 ChaC7 (Chassatide C7; uncyclotides; Plant defensin) No entry found "Belongs to the Bracelet subfamily, Rubiaceae family" Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "IC50=1.2 ?M, HD50=11.6 ?M. Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC=6.4 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50 = 11.6 M against on human red blood cells (Type A). Kalata B1 and melittin were used as the positive control. Linear Free Free None L [Ref.22467870] IC50 = 1.2 M targeting on HeLa cells. Kalata B1 was used as the positive control. Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00337 AIPCGESCVWIPCISTVIGCSCSNKVCYR 29 ChaC8 (Chassatide C8; uncyclotides; Plant defensin) No entry found "Belongs to the Bracelet subfamily, Rubiaceae family" Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "IC50=1.0 ?M, HD50=25.5 ?M. Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC=6.6 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50 = 25.5 M against human red blood cells (Type A). Kalata B1 and melittin were used as the positive control. Linear Free Free None L [Ref.22467870] IC50 = 1.0 M targeting on HeLa cells. Kalata B1 was used as the positive control. Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00338 IPCGESCVWIPCISGMFGCSCKDKVCYS 28 ChaC11 (Chassatide C11; uncyclotides; Plant defensin) No entry found "Belongs to the Bracelet subfamily, Rubiaceae family" Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "IC50=1.2 ?M, HD50=13.3 ?M. Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC=8.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50 = 13.3 M against human red blood cells (Type A). Kalata B1 and melittin were used as the positive control. Linear Free Free None L [Ref.22467870] IC50 = 5.0 M targeting on HeLa cells. Kalata B1 was used as the positive control. Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00385 QLPICGETCVLGGCYTPNCRCQYPICVR 28 Panitide L2 (plants) No entry found Not found Not found Panicum laxum "Antimicrobial, Antibacterial, Anti-Gram-" Not found Bridge Not found None PTM: N-terminus is a pyruglutamyl. Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Pyroglutamyl modification Free There are three disulfide bonds in the peptide structure L [Ref.23195955] IC50 = 6.0 M against HeLa cells. Not found 23195955 J Biol Chem. 2013 Feb 1;288(5):3370-3380. "Nguyen GK, Lian Y, Pang EW, Nguyen PQ, Tran TD, Tam JP." Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. DRAMP00431 KTCMTKKEGWGRCLIDTTCAHSCRKYGYMGGKCQGITRRCYCLLNC 46 Defensin-like protein 2 (Cp-thionin II; Cp-thionin-2; Gamma-thionin II; Plant defensin) P84920 Belongs to the DEFL family Not found Vigna unguiculata (Cowpea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli and P. syringae. Does not have antibacterial activity against the phytopathogenic bacteria R. solanacearum, Rhataybacter sp and Erwinia sp. Does not inhibit trypsin, chymotrypsin or alpha-amylases. Tissue specificity: Present in seeds, cotyledons and leaves. Not found in roots or stems. Developmental stage: Present in seeds and seedlings, levels decrease with seedling age. Light increases the rate of degradation. Present until 9 days in seedlings kept in the dark, not found after 6 days in seedings kept in the light. PTM: Contains four disulfide bonds 3-46; 13-33; 19-40; 23-42." "Gram-positive bacterium: Staphylococcus aureus ATTC 25923 (MIC=128 mg/ml);##Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=64 mg/ml), Pseudomonas syringae (MIC=42 mg/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) "There are four disulfide bonds between Cys3 and Cys46, Cys13 and Cys33, Cys19 and Cys40, Cys23 and Cys42" L No cytotoxicity information found Not found 16824043 FEBS J. 2006 Aug;273(15):3489-3497. "Franco OL, Murad AM, Leite JR, Mendes PA, Prates MV, Bloch C Jr." Identification of a cowpea gamma-thionin with bactericidal activity. DRAMP00764 KSLRPRCWIKIKFRCKSLKF 20 Piceain 1 (Plants) No entry found Not found Not found Picea sitchensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Beta strand (CD) Not found None "Function: Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells. PTM: Contains one disulfide bond." "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 ?g/ml), S. aureus ATCC 43300 (MIC=9.38 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=18.75 ?g/ml), Escherichia coli ML-35P (MIC=18.75 ?g/ml), Escherichia coli 08040722 (CI) (MIC=75 ?g/ml), Escherichia coli 08A866 (CI) (MIC=37.5 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 ?g/ml).##Yeast: Candida albicans ATCC 20032 (MIC=9.38 ?g/ml)." "[Ref.21644248] At the concentration of 0.0625 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.7% & 1.5%; At the concentration of 0.125 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 7.2%; At the concentration of 0.25 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.9%&7.8%; At the concentration of 0.5 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.6% & 9.5%; At the concentration of 1 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.8% & 57.1%." Cyclic Free Free There is one intra-molecular disulfide bridge formed by Cys7 and Cys15. L No cytotoxicity information found Not found 21644248 J Pept Sci. 2011 Sep;17(9):627-631. "Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R." Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis. DRAMP00765 RPRCWIKIKFRCKSLKF 17 Piceain 2 (Plants) No entry found Not found Not found Picea sitchensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells. PTM: Contains one disulfide bond." "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 ?g/ml), S. aureus ATCC 43300 (MIC=18.75 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=37.5 ?g/ml), Escherichia coli ML-35P (MIC=37.5 ?g/ml), Escherichia coli 08040722 (CI) (MIC=75 ?g/ml), Escherichia coli 08A866 (CI) (MIC=37.5 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=18.75 ?g/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 ?g/ml).##Yeast: Candida albicans ATCC 20032 (MIC=18.75 ?g/ml)." "[Ref.21644248] At the concentration of 0.0625 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.6% & 2.2%; At the concentration of 0.125 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 4.7%; At the concentration of 0.25 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.2%&5.2%; At the concentration of 0.5 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.3% & 12.4%; At the concentration of 1 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 11.3% & 66.3%." Cyclic Free Free There is one intra-molecular disulfide bridge formed by Cys4 and Cys12. L No cytotoxicity information found Not found 21644248 J Pept Sci. 2011 Sep;17(9):627-631. "Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R." Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis. DRAMP00766 KVFLGLK 7 JCpep7 (Plants) No entry found Not found Not found Jatropha curcas "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: JCpep7 killed microbes principally via breaking of their cell walls and membranes, followed by cell lysis." "Gram-negative bacteria: Salmonella typhimurium ATCC 50013 (MIC=48 ?g/ml), Shigella dysenteriae ATCC 51302 (MIC=48 ?g/ml), Pseudomonas aeruginosa ATCC 27553 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=40 ?g/ml), Bacillus subtilis ATCC 23631 (MIC=24 ?g/ml), Streptococcus pneumoniae ATCC 49619 (MIC=56 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 21268582 J Agric Food Chem. 2011 Feb 23;59(4):1145-1151. "Xiao J, Zhang H, Niu L, Wang X." Efficient Screening of a Novel Antimicrobial Peptide from Jatropha curcas by Cell Membrane Affinity Chromatography. DRAMP00774 GTRCGETCFVLPCWSAKFGCYCQKGFCYRN 30 Hedyotide B1 (hB1; Plants) No entry found Belongs to the cyclotide family Not found Hedyotis biflora (aerial tissues) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=3.4 ?M);##Gram-positive bacteria: Streptococcus salivarius(MIC=5.9 ?M), Staphylococcus epidermidis (MIC>80 ?M), S. aureus (MIC>80 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free There are three disulfide bonds in the peptide structure L No cytotoxicity information found Not found 21979955 J Biol Chem. 2011 Dec 30;286(52):44833-44844. "Nguyen GK, Zhang S, Wang W, Wong CT, Nguyen NT, Tam JP." Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. DRAMP00795 GIPCGESCVFIPCITAAIGCSCKSKVCYRN 30 Cliotide T1 (cT1; Plant defensin) No entry found Belongs to the cyclotide family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Cliotide T1 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=7.1 ?M) and cytotoxicity against HeLa Cells (IC50=0.6 ?M). [Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. " "[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC=1.1 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC=2.7 ?M), Klebsiella pneumonia ATCC 13883 (MIC=4.7 ?M)." [Ref.21596752] HD50 = 7.1 M against human red blood cells Cyclic Free Free "There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27." L [Ref.21596752] IC50=0.6 ?M against HeLa cells. Not found 21596752 J Biol Chem. 2011 Jul 8;286(27):24275-24287. "Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP." Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. DRAMP00798 GIPCGESCVFIPCITGAIGCSCKSKVCYRN 30 Cliotide T4 (cT4; Plant defensin) No entry found Belongs to the cyclotide family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Cliotide T4 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=8.4 ?M) and cytotoxicity against HeLa Cells (IC50=0.6 ?M). [Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. " "[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC=1.3 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC=1.9 ?M), Klebsiella pneumonia ATCC 13883 (MIC=1.5 ?M)." [Ref.21596752] HD50 = 8.4 M against human red blood cells Cyclic Free Free "There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27." L [Ref.21596752] IC50=0.6 ?M against HeLa cells. Not found 21596752 J Biol Chem. 2011 Jul 8;286(27):24275-24287. "Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP." Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. DRAMP00856 GLPVCGETCVGGTCNTPGCTCSWPVCTRN 29 Kalata-B1 (Plant defensin) P56254 Belongs to the cyclotide family OAK1 Oldenlandia affinis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Beta strand (3 strands; 7 residues) Not found 2KHB resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans. Active against the Gram-positive S. aureus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. Inhibitory effect on the growth and development of larvae from H. punctigera. The unmodified form has hemolytic activity, the oxidized form lacks hemolytic activity. If the protein is linearized, hemolytic activity is lost. MOA: a small number of cyclotides bind to the membrane surface and then insert first into the outer membrane leaflet followed by penetration through the membrane and pore formation. At higher concentrations of cyclotides, destabilization of membranes occurs. Tissue specificity: Leaves and stems. Lower in roots. Pharmaceutical use: The uteroactive properties of Kalata have been discovered by African traditional medicine. It is used as an ingredient of a herbal tea to accelerate childbirth. PTM: Kalata-B1 is a cyclic peptide which contains three disulfide bonds 5-19; 11-21; 14-26." "[Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.26 ?M), Micrococcus luteus (MIC=40.4 ?M);##Gram-negative bacterium: Klebsiella oxytoca (MIC=54.8 ?M);##Fungi: Candida kefyr (MIC=21.4 ?M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=140 nM)." [Ref.12779323] HD50 = 300 M against Human type A red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.7703226] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys26." L [Ref.18008336]CEM-SS cells:IC50=3500 nM. Cell membrance 18008336##10430870##7703226##17534989##23129773 Biopolymers. 2008;90(1):51-60.##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biochemistry. 1995 Apr 4;34(13):4147-4158.##Chembiochem. 2007 Jun 18;8(9):1001-1011.##J Biol Chem. 2012 Dec 21;287(52):43884-98. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, G?ransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ." "Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions." DRAMP00877 GIPCGESCVWIPCISAALGCSCKNKVCYRN 30 Circulin-A (CIRA; Plant defensin) P56871 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Alpha helix (1 helices; 4 residues) "The molecule is stabilised by three disulfide bonds, two of which form an embedded loop completed by the backbone fragments connecting the cysteine residues. A third disulfide bond threads through the centre of this loop to form a ""cystine-knot"" motif. This motif is present in a range of other biologically active proteins, including omega-contoxin GVIA and Cucurbita maxima trypsin inhibitor." 1BH4 resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. PTM: This is a cyclic peptide which contains three disulfide bonds 1-17; 5-19; 10-24." [Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.19 ?M).##Gram-negative bacterium: Proteus vulgaris (MIC=54.6 ?M).##Fungi: Candida kefyr (MIC=18.6 ?M) and Candida tropicalis (MIC=19.4 ?M).##NOTE: Medium with 10 mM phosphate buffer.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM). [Ref.10430870] EC50 = 1020 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.8920961] There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27" L [Ref.18008336]CEM-SS cells:IC50=500 nM. Not found 18008336##10430870##9878410##8920961 Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. ##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J. Mol. Biol. 1999; 285:333-345. ##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##Tam JP, Lu YA, Yang JL, Chiu KW.##Daly NL, Koltay A, Gustafson KR, Boyd MR, Casas-Finet JR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell" "Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides" DRAMP00878 GVIPCGESCVFIPCISTLLGCSCKNKVCYRN 31 Circulin-B (CIRB; Plant defensin) P56879 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Beta strand (5 strands; 10 residues) Cyclotides are mini-proteins derived from plants that have the characteristic features of a head-to-tail cyclised peptide backbone and a knotted arrangement of their three disulfide bonds. 2ERI resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria. PTM: This is a cyclic peptide which contains three disulfide bonds 5-21; 9-23; 14-28." "[Ref.10430870]Gram-positive bacterium: (L-salt): Staphylococcus aureus (MIC=13.5 ?M).##Gram-negative bacteria: (L-salt, H-salt) (MIC ?M): Escherichia coli (0.41, >500), Pseudomonas aeruginosa (25.5, 48), Proteus vulgaris (6.8, >500), Klebsiella oxytoca (8.2, 15.6).##Fungi (H-salt): Candida kefyr (MIC=29 ?M).##NOTE: L-salt = Medium with 10 mM phosphate buffer; H-salt = L-salt supplemented with 100 mM NaCl.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM)." [Ref.10430870] EC50 = 550 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.8920961] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys27." L [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 820 M.##[Ref.18008336]CEM-SS cells:IC50=500 nM. Not found 10430870##18008336##8920961 Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biopolymers. 2008;90(1):51-60.##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. doi: 10.1006/bbrc.1996.1708. "Tam JP, Lu YA, Yang JL, Chiu KW.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell" "An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclotides as natural anti-HIV agents.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides" DRAMP01374 GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC 33 "Odorranain-D1 (OdD1; Frogs, amphibians, animals)" A6MBK7 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-D1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=16.32 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8.16 g/ml), Bacillus subtilis (MIC=8.16 g/ml).##Yeast: Candida albicans (MIC=4.08 g/ml)." [Ref:17272268]Non-hemolytic activity against rabbit red blood cells Cyclic Free Cyclization(Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.17272268]No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01373 GVLGAVKDLLIGAGKSAAQSVLKTLSCKLSNDC 33 "Odorranain-C1 (OdC1; Frogs, amphibians, animals)" A6MBF6 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-C1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=8.21 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.11 g/ml), Bacillus subtilis (MIC=16.42 g/ml).##Yeast: Candida albicans (MIC=2.05 g/ml)." [Ref:17272268] No detectable hemolytic activity against rabbit red blood cells. Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) [Ref:17272268] There are one disulfide bond between Cys27 and Cys33 L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01372 AALKGCWTKSIPPKPCFGKR 20 "Odorranain-B1 (OdB1; Frogs, amphibians, animals)" E7EKD9 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana hainanensis (Odor frog) (Rana hainanensis) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Homology Not found Odorranain-B1 adopts 5.9 % None "Function: Odorranain-B1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. Tissue specificity: Expressed by the skin glands." "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.21 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=5.83 g/ml), Bacillus subtilis (MIC=1.85 g/ml).##Yeast: Candida albicans (MIC=2.4 g/ml)." [Ref:17272268] No detectable hemolytic activity against rabbit red blood cells. Cyclic Free Free [Ref:17272268] There are one disulfide bond between Cys6 and Cys16 L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP00933 SAFTVWSGPGCNNRAERYSKCGCSAIHQKGGYDFSYTGQTAALYNQAGCSGVAHTRFGSSARACNPFGWKSIFIQC 76 Antimicrobial peptide 1 (AMP1; MiAMP1; Plant defensin) P80915 Not found Not found Macadamia integrifolia (Macadamia nut) "Antimicrobial, Antibacterial, Antifungal" Protein level Combine helix and strand structure MiAMP1 is made up of eight beta-strands which are arranged in two Greek key motifs. These Greek key motifs associate to form a Greek key beta-barrel. This structure is unique amongst plant antimicrobial proteins and forms a new class which we term the beta-barrelins. (Ref.2) 1C01 resolved by NMR. "Function: Antimicrobial peptide which inhibits the growth of a variety of fungi, oomycetes, Gram-positive bacterial phytopatogenes and S.cerevisiae in vitro. No activity against E.coli. Miscellaneous: Its antimicrobial activity is diminished by calcium an" "Alternaria helianthi (MIC=2-5 ?g/ml), Botrytis cinerea (MIC=5-10 ?g/ml), Ceratocystis parodoxa (MIC=20 ?g/ml), Colletotrichum gloeosporioides (MIC=2-5 ?g/ml), Fusurium oxysporum (MIC=2-5 ?g/ml), Leptosphaeria maculans (MIC=5 ?g/ml), Macrophomina phaseolina (MIC<25 ?g/ml), Phytophthoru cryptogea (MIC=5-10 ?g/ml), Pythium graminicola (MIC=5 ?g/ml), Sclerotinia sclerotiorum spores (MIC=5 ?g/ml), Sclerotinia sclerotiorum mycelia (MIC=50 ?g/ml), Verticilium dahliae (MIC=2 ?g/ml), Clavibacter michiganensis (MIC<10 ?g/ml), Saccharomyces cerevisiae (MIC=2-5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) "[Ref.10543955] There are three disulfide bonds between Cys11 and Cys64, Cys21 and Cys76, Cys23 and Cys49" L No cytotoxicity information found Not found 9108242##10543955 Eur J Biochem. 1997 Mar 15;244(3):743-749.##J Mol Biol. 1999 Oct 29;293(3):629-638. "Marcus JP, Goulter KC, Green JL, Harrison SJ, Manners JM.##McManus AM, Nielsen KJ, Marcus JP, Harrison SJ, Green JL, Manners JM, Craik DJ." "Purification, characterisation and cDNA cloning of an antimicrobial peptide from Macadamia integrifolia.##MiAMP1, a novel protein from Macadamia integrifolia adopts a Greek key beta-barrel fold unique amongst plant antimicrobial proteins." DRAMP01012 RESPSSRMECYEQAERYGYGGYGGGRYGGGYGSGRGQPVGQGVERSHDDNRNQPR 55 Pg-AMP (Gly-rich; Plants) P86030 Not found Not found Psidium guajava (Guava) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-negative bacteria. Does not have antifungal activity against the human and plant pathogenic fungi F. oxysporum, A. fumigatus and R. solani. Subunit structure: Monomer and homodimer. Might act by homodimer formation." "Gram-negative bacteria: Klebsiella sp., Proteus sp., Escherichia coli ATCC 8739 (MIC=72 mg/ml), Klebsiella pneumoniae (MIC=32 mg/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 18448201 Peptides. 2008 Aug;29(8):1271-1279. "Pelegrini PB, Murad AM, Silva LP, Dos Santos RC, Costa FT, Tagliari PD, Bloch C Jr, Noronha EF, Miller RN, Franco OL." Identification of a novel storage glycine-rich peptide from guava (Psidium guajava) seeds with activity against Gram-negative bacteria. DRAMP01016 QCIGNGGRCNENVGPPYCCSGFCLRQPGQGYGYCKNR 37 Antimicrobial peptide 1 (MJ-AMP1; Plant defensin) P25403 Belongs to the AMP family AMP1 Mirabilis jalapa (Garden four-o'clock) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Bridge Not found None "Function: Possesses antifungal activity and is also active on two tested Gram-positive bacteria: but is non-toxic for Gram-negative bacteria and cultured human cells. Tissue specificity: Found only in seeds. PTM: Contains three disulfide bonds 2-19; 9-23;" "Fungi: Alternaria brassicola (MIC=20 ?g/ml), Ascochyta pisi (MIC=200 ?g/ml), Botrytis cinerea (MIC=50 ?g/ml), Cercospora beticola (MIC=10 ?g/ml), Colletotrichum lindemuthianum (MIC=6 ?g/ml), Fusarium culmorum (MIC=30 ?g/ml), Fusarium oxysporum f.sp.pisi (MIC=15 ?g/ml), Fusarium oxysporum f.sp.lycopersici (MIC=200 ?g/ml), Nectria haematococca (MIC=15 ?g/ml), Phoma betae (MIC=25 ?g/ml), Pyrenophora tritici-repentis (MIC=300 ?g/ml), Pyricularia oryzae (MIC=6 ?g/ml), Rhizoctonia solani (MIC=60 ?g/ml), Verticillium dahliae (MIC=12 ?g/ml), Venturia inequalis (MIC=12 ?g/ml).##Gram-positive bacteria: Bacillus megaterium (MIC=6 ?g/ml), Sarcina lutea (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Pyroglutamyl modification (Cyclization of a N-terminal glutamine) Free "There are three disulfide bonds between Cys2 and Cys19, Cys9 and Cys23, Cys18 and Cys34." L No cytotoxicity information found Not found 1733929##7647302 J. Biol. Chem. 1992;267:2228-2233.##Plant Mol. Biol. 1995;28:713-721. "Cammue B.P.A, de Bolle M.F.C, Terras F.R.G, Proost P, van Damme J, Rees S.B, Vanderleyden J, Broekaert W.F.##de Bolle M.F, Eggermont K, Duncan R.E, Osborn R.W, Terras F.R.G, Broekaert W.F." Isolation and characterization of a novel class of plant antimicrobial peptides from Mirabilis jalapa L. seeds.##Cloning and characterization of two cDNA clones encoding seed-specific antimicrobial peptides from Mirabilis jalapa L. DRAMP01017 CIGNGGRCNENVGPPYCCSGFCLRQPNQGYGVCRNR 36 Antimicrobial peptide 2 (MJ-AMP2; Plant defensin) P25404 Belongs to the AMP family AMP2 Mirabilis jalapa (Garden four-o'clock) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Bridge Not found None Function: Possesses antifungal activity and is also active on two tested Gram-positive bacteria: but is non-toxic for Gram-negative bacteria and cultured human cells. Tissue specificity: Found only in seeds. PTM: Contains three disulfide bonds 1-18; 8-22; "Fungi: Alternaria brassicola (MIC=6 ?g/ml), Ascochyta pisi (MIC=6 ?g/ml), Botrytis cinerea (MIC=2 ?g/ml), Cercospora beticola (MIC=2 ?g/ml), Colletotrichum lindemuthianum (MIC=1 ?g/ml), Fusarium culmorum (MIC=3 ?g/ml), Fusarium oxysporum f.sp.pisi (MIC=5 ?g/ml), Fusarium oxysporum f.sp.lycopersici (MIC=10 ?g/ml), Nectria haematococca (MIC=0.5 ?g/ml), Phoma betae (MIC=6 ?g/ml), Pyrenophora tritici-repentis (MIC=20 ?g/ml), Pyricularia oryzae (MIC=0.5 ?g/ml), Rhizoctonia solani (MIC=15 ?g/ml), Verticillium dahliae (MIC=0.5 ?g/ml), Venturia inequalis (MIC=1 ?g/ml).##Gram-positive bacteria: Bacillus megaterium (MIC=2 ?g/ml), Sarcina lutea (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization of a N-terminal Cys residue (forming a disulfide bond) Free "There are three disulfide bonds between Cys1 and Cys18, Cys8 and Cys22, Cys17 and Cys33." L No cytotoxicity information found Not found 1733929##7647302 J Biol Chem. 1992 Feb 5;267(4):2228-2233.##Plant Mol Biol. 1995 Jul;28(4):713-721. "Cammue BP, De Bolle MF, Terras FR, Proost P, Van Damme J, Rees SB, Vanderleyden J, Broekaert WF.##De Bolle MF, Eggermont K, Duncan RE, Osborn RW, Terras FR, Broekaert WF." Isolation and characterization of a novel class of plant antimicrobial peptides form Mirabilis jalapa L. seeds.##Cloning and characterization of two cDNA clones encoding seed-specific antimicrobial peptides from Mirabilis jalapa L. DRAMP01018 SIPCGESCVFIPCTVTALLGCSCKSKVCYKN 31 Cyclopsychotride-A (CPT; Plant defensin) P56872 Not found Not found Psychotria longipes "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-21; 8-23; 13-28." "Gram-negative bacteria: Escherichia coli (MIC=1.55 ?M), Pseudomonas aeruginosa (MIC=13.5 ?M), Proteus vulgaris (MIC=13.2 ?M), Klebsiella oxytoca (MIC=5.80 ?M).##Gram-positive bacteria: Staphylococcus aureus (MIC=39.0 ?M), Micrococcus luteus (MIC=48.0 ?M).##Fungi: Candida albicans (MIC>500 ?M), Candida kefyr (MIC=14.0 ?M), Candida tropicalis (MIC=56.5 ?M).##NOTE: Medium with 10 mM phosphate buffer." [Ref.10430870] HD50 = 405 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "There are three disulfide bonds between Cys4 and Cys21, Cys8 and Cys23, Cys13 and Cys28" L [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 1850 M. Not found 10430870##7714530 Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J Nat Prod. 1994 Dec;57(12):1619-1625. "Tam JP, Lu YA, Yang JL, Chiu KW.##Witherup KM, Bogusky MJ, Anderson PS, Ramjit H, Ransom RW, Wood T, Sardana M. " "An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes." DRAMP18193 KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF 34 Cathelicidin-related peptide crotalicidin U5KJM4 Belongs to the cathelicidin family. Not found Crotalus durissus terrificus (South American rattlesnake) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found alpha helical Not found 2MWT resolved by NMR "Function: Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane (By similarity). Hemolytic activities have been observed on mammalian cells. Expressed by the venom gland." "[Ref.25100358]Gram-negative: E.coli ATCC 25922 (MIC=0.25 g/mL),P.aeruginosa (MIC=1 g/mL);##Gram-positive: E.faecalis (MIC=32 g/mL), S.aureus (MIC=32 g/mL)." "[Ref.25100358] Crotalicidin reached 10% hemolysis at 25 M. Even so, extrapolation of existing data indicates that 50% hemolysis would be reached at near-millimolar values, which defines an adequate (~2 log) selectivity window." Cyclic Free Amidation None L No cytotoxicity information found cell membrane 25100358 Amino Acids 46:2561-2571(2014) "Falcao C.B., de La Torre B.G., Perez-Peinado C., Barron A.E.,Andreu D., Radis-Baptista G." Vipericidins: a novel family of cathelicidin-related peptides fromthe venom gland of South American pit vipers. DRAMP01064 AWKLFDDGV 9 Anticancerous peptide 1 (Cr-ACP1; Plants) B3EWE7 Not found Not found Cycas revoluta (Sago palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None "Function: The synthetic peptide inhibits cell proliferation and induces apoptosis in cancer-derived cell lines Hep2 (IC50=1.5 mM) and HCT15 and, to a lesser extent, in non-cancerous NIH/3T3 cells. The mode of action is presumably an arrest in the G0/G1 phase. Antiproliferative, proapoptotic and DNA-binding activities are increased by acetylation at Ala-1 and Lys-3. Has a weak hemolytic activity against mouse erythrocytes. Has antibacterial activity. Antibacterial activity is decreased by acetylation. " "[Ref.21882228]Gram-positive bacteria: Staphylococcus epidermidis (MIC=60 ?M), Bacillus subtilis (MIC=30 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=30 ?M), EEscherichia coli strain ATCC 8739 (MIC=30 ?M)." [Ref.21882228] Hemocompatibility study revealed the effectiveness of both the peptides where it showed no significant lysis of normal RBC cells compare to positive control (Triton X-100). Cr-ACP1 induced hemolysis of 7% at the conentration of 1 mM. Linear Free Free None L [Ref.21882228] IC50 = 1.5 mM in Hep2 (Human epidermoid cancer cells); IC50 = 0.9 mM in HCT15 (human colon carcinoma cells HCT15); Cr-ACP1 induced a cell viability of 66% at the concentration of 4 mM. DNA 21882228 J Cell Biochem. 2012 Jan;113(1):184-193. "Mandal SM, Migliolo L, Das S, Mandal M, Franco OL, Hazra TK." Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties. DRAMP01066 PVVDTTGNNPLQQQEEYYV 19 Kunitz-type serine protease inhibitor 1 (Xb-KTI; Plants) P86930 Not found Not found Xanthosoma sagittifolium (Elephant's ear) (Arum sagittifolium) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Function: Serine protease inhibitor. Displays antimicrobial activity against the Gram-negative bacterium S. typhimurium ATCC 14028. Displays a weak hemolytic activity. [Ref.21520894]Gram-negative bacterium: Salmonella typhimurium ATCC 14028 (MIC=10 ?M). [Ref.21520894] No hemolytic activity was observed for Xb-KTI. The peptide induced a hemolysis of 12% at the highest concentration of 250 g/mL. Values(OD540) were normalized against 100% lysed erythrocytes (0.1% Triton X-100) and PDB (untreated control) Linear Free Free None L No cytotoxicity information found Not found 21520894 J Nat Prod. 2011 May 27;74(5):969-975. "Lima TB, Silva ON, Migliolo L, Souza-Filho CR, Gon?alves EG, Vasconcelos IM, Oliveira JT, Amaral AC, Franco OL." A Kunitz proteinase inhibitor from corms of Xanthosoma blandum with bactericidal activity. DRAMP01081 GLKDIFKAGLGSLVKGIAAHVAN 23 "Alyteserin-1a (toads, amphibians, animals)" No entry found Not found Not found Alytes obstetricans (European midwife toad) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: The alyteserin-1 peptides show selective growth inhibitory activity against the Gram-negative bacterium Escherichia coli. The hemolytic activity against human erythrocytes of all peptides tested is relatively weak. Structural similarity: The alyteserin-1 peptides show limited structural similarity to the ascaphins from the skins of frogs of the family Leiopelmatidae." [Ref.19463738]Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:19463738] LC50 > 100 M against human erthrocytes. Alyteserin-1a induced a hemolysis of 11% at the concentration of 100 M. Linear Free -Amidation None L (to be determined) No cytotoxicity information found Not found 19463738 Peptides. 2009 Jun;30(6):1069-1073. "Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01082 ILGKLLSTAAGLLSNL 16 "Alyteserin-2a (toads, amphibians, animals)" No entry found Not found Not found Alytes obstetricans (European midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Cytotoxicity" Not found Alpha helix It is helical in 50% TFE. None "Function: The alyteserin-2a is more potent against the Gram-positive bacteria Staphylococcus aureus. The hemolytic activity against human erythrocytes of all peptides tested is relatively weak. Structural similarity: Alyteserin-2a and alyteserin-2b and -2c show limited sequence identity with bombinin H6, present in the skins of frogs of the family Bombinatoridae." [Ref.19463738]Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M). [Ref:19463738] LC50 = 135 M against human erthrocytes. Linear Free -Amidation None L (to be determined) No cytotoxicity information found Not found 19463738 Peptides. 2009 Jun;30(6):1069-1073. "Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01083 GLKEIFKAGLGSLVKGIAAHVAN 23 "Alyteserin-1b (toads, amphibians, animals)" No entry found Not found Not found Alytes obstetricans (European midwife toad) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Amtimicrobial peptide. (By similarity) Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:19463738] LC50 = 210 M against human erthrocytes. Linear Free -Amidation None L (to be determined) No cytotoxicity information found Not found 19463738 Peptides. 2009 Jun;30(6):1069-1073. "Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01085 GLKEIFKAGLGSLVKGIAAHVAS 23 "Alyteserin-1c (toads, amphibians, animals)" H0USY4 Not found Not found Alytes obstetricans (Common midwife toad) (Bufo obstetricans) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Alpha helix "Solution structural studies in the membrane mimicking environments, sodium dodecyl sulphate (SDS), dodecylphosphocholine (DPC), and 1,2-dihexanoyl-sn-glycero-3-phosphatidylcholine (DHPC) micelles, indicate that these peptides display an alpha helical structure between residues Lys(3) and Val(21).(Ref.1)" 2L5R resolved by NMR. Function: Alyteserin-1c shows selective growth-inhibitory activity against Gram-negative bacteria. Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:19463738] LC50 = 145 M against human erthrocytes. Linear Free -Amidation None L (to be determined) No cytotoxicity information found Not found 21565166##19463738 Biochim Biophys Acta. 2011 Aug;1808(8):1975-1984.##Peptides. 2009 Jun;30(6):1069-1073. "Subasinghage AP, O'Flynn D, Conlon JM, Hewage CM.##Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." Conformational and membrane interaction studies of the antimicrobial peptide alyteserin-1c and its analogue [E4K]alyteserin-1c.##The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01088 GFKEVLKADLGSLVKGIAAHVAN 23 "Alyteserin-1Ma (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Alyteserin-1Ma has lower antimicrobial potencies (MIC>200 ?M). Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=214 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=214 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01089 GFKEVLKAGLGSLVKGIPAHVAN 23 "Alyteserin-1Mb (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Alyteserin-2Ma has lower antimicrobial potencies (MIC>200 ?M). Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=217 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=434 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01090 FIGKLISAASGLLSHL 16 "Alyteserin-2Ma (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli and Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 150 microM. Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=38.4 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=9.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01091 ILGAIIPLVSGLLSHL 16 "Alyteserin-2Mb (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Has antibacterial activity against the Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 310 microM. Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=19.3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01096 GIGSAILSAGKSALKGLAKGLAEHFAN 27 "Bombinin-like peptide 2 (BLP-2; toads, amphibians, animals)" P29003 Belongs to the bombinin family Not found Bombina orientalis (Oriental fire-bellied toad) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria. Tissue specificity: Expressed by the skin glands." "[Ref.1744108]Gram-negative bacterium: 58% inhibition Neisseria meningitidis 118V C (MIC=20 ?g/ml), 98% inhibition Neisseria meningitidis 15240 IAI (MIC=20 ?g/ml), 98% inhibition Neisseria meningitidis 126E IC1 (MIC=20 ?g/ml), 97% inhibition Neisseria gonorrhoeoe F62 (MIC=20 ?g/ml), 99% inhibition Neisseria Iactamica 15323 (MIC=20 ?g/ml), 100% inhibition Neisseria Iactamica 15215A (MIC=20 ?g/ml), 95% inhibition Neisseria cinerea 15461 (MIC=20 ?g/ml)." [Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes. Cyclic Free Amidation None L No cytotoxicity information found Not found 1744108 J. Biol. Chem. 1991; 266: 23103-23111. "Gibson BW, Tang D, Mandrell R, Kelly M, Spindel ER." "Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis." DRAMP03017 FMPIIGRLMSGSL 13 "VESP-VB1 (Insects, animals)" No entry found Not found Not found vespine wasps Vespa bicolor "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has antimicrobial activities against standard strains and strong antimicrobial ability against drug-resistant strains. Among the tested drug-resistant strains, Pseudemonas aeruginosa and Staphylococcus aureus were the most sensitive for this kind of antimicrobial peptide. Has a little hemolytic activity." "[Ref.18723059] Gram-negative bacterium: Escherichia coli ATCC25922(MIC=7.5g/ml), Escherichia coli 23A(MIC=7.5g/ml), Escherichia coli 27A(MIC=15.0g/ml), Pseudemonas aeruginosa 3A(MIC=3.75g/ml), Pseudemonas aeruginosa 7A(MIC=3.75g/ml), ;## Gram-positive bacterium: Staphylococcus aureus ATCC2592(MIC=1.9g/ml), Staphylococcus aureus 6A(MIC=3.75g/ml), Staphylococcus aureus 15A(MIC=1.0g/ml);## Fungus: Candida albicans ATCC2002(MIC=30.0g/ml)" "[Ref.18723059] VESP-VB1 had a little hemolytic activity of 10.2% against rabbit red blood cells, and of 3.2% against human red blood cells with peptide concentration up to 200 g/ml" Linear Free Free None L No cytotoxicity information found Not found 18723059 Peptides. 2008 Nov;29(11):1887-1892. "Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, Yu H." Antimicrobial peptides from the venoms of Vespa bicolor Fabricius. DRAMP01098 GIGAAILSAGKSALKGLAKGLAEHF 25 "Bombinin-like peptide 3 (BLP-3; toads, amphibians, animals)" P29004 Belongs to the bombinin family Not found Bombina orientalis (Oriental fire-bellied toad) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Alpha helix Not found None "Function: Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria. Tissue specificity: Expressed by the skin glands." "[Ref.1744108]Gram-postive bacterium:Bacillus megaterium BmII (MIC=0.3 ?M), Staphylococcus aureus Cowan1 (MIC=1.7 ?M);##Gram-negative bacterium:59% inhibition Neisseria meningitidis 118V C (MIC=20 ?g/ml), 99% inhibition Neisseria meningitidis 15240 IAI (MIC=20 ?g/ml), 99% inhibition Neisseria meningitidis 126E IC1 (MIC=20 ?g/ml), 99% inhibition Neisseria gonorrhoeoe F62 (MIC=20 ?g/ml), 97% inhibitionNeisseria Iactamica 15323 (MIC=20 ?g/ml), 100% inhibition Neisseria Iactamica 15215A (MIC=20 ?g/ml), 97% inhibition Neisseria cinerea 15461 (MIC=20 ?g/ml), Escherichia coli D21 (MIC=1.7 ?M), Escherichia coli D22 (MIC=1.5 ?M), Yersinia pseudotubercolosis (MIC=0.6 ?M), Pseudomonas aeruginosa ATCC 15692 (MIC=9.2 ?M);##Fungus:Candida albicans (MIC=0.4 ?M)." [Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes. Cyclic Free Amidation None L No cytotoxicity information found Not found 1744108 J Biol Chem. 1991 Dec 5;266(34):23103-23111. "Gibson BW, Tang DZ, Mandrell R, Kelly M, Spindel ER." "Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis." DRAMP01105 RSNKGFNFMVDMIQALSK 18 "Maximin-S4 (chain of Maximins-S type B/C; toads, amphibians, animals)" Q5GC92 Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial" Protein level Not found Not found None Function: Maximin-S3 has an activity against mycoplasma but has no activity against common Gram-positive and Gram-negative bacteria nor fungi. Has no hemolytic activity. Tissue specificity: Expressed by the skin dorsal glands. PTM: Lysine amide at position 18. "[Ref.15649437]Mycoplasma humenis (MIC=46 ?M), Ureaplasma urealyticum (MIC=46 ?M)." [Ref:15649437] Maximin S1 and S4 had no hemolytic activity. Linear Free Amidation None L No cytotoxicity information found Not found 15649437 Biochem Biophys Res Commun. 2005 Feb 18;327(3):945-951. "Wang T, Zhang J, Shen JH, Jin Y, Lee WH, Zhang Y." "Maximins S, a novel group of antimicrobial peptides from toad Bombina maxima." DRAMP02090 FLPMLAGLAASMVPKFVCLITKKC 24 "Brevinin-1Lb (Frogs, amphibians, animals)" P82826 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana luteiventris (Spotted frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=8 M);##Gram-negative bacterium: Escherichia coli (MIC=16 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free There is a disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP02091 FLPFIAGMAAKFLPKIFCAISKKC 24 "Brevinin-1Ba (Frogs, amphibians, animals)" P82833 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana berlandieri (Rio Grande leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=2 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01829 FLPILINLIHKGLL 14 "Temporin-1Lc (Temporin 1Lc; Frogs, amphibians, animals)" P82832 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana luteiventris (Spotted frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. PTM: Leucine amide at position 14. " [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=125 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01828 NFLGTLINLAKKIM 14 "Temporin-1Lb (Temporin 1Lb; Frogs, amphibians, animals)" P82831 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana luteiventris (Spotted frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. PTM: Methionine amide at position 14. " [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=48 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01518 GILSLFTGGIKALGKTLFKMAGKAGAEHLACKATNQC 37 "Esculentin-2L (Frogs, amphibians, animals)" P82827 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana luteiventris (Great Basin spotted frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=3 M);##Gram-negative bacterium: Escherichia coli (MIC=6 M).##Yeast: Candida albicans (MIC=53 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01827 VLPLISMALGKLL 13 "Temporin-1La (Temporin 1La; Frogs, amphibians, animals)" P82830 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana luteiventris (Spotted frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. PTM: Leucine amide at position 13. " [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01517 GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC 37 "Esculentin-2P (Frogs, amphibians, animals)" P82846 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana pipiens (northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antiviral" Protein level Not found Not found None "Function: Antibacterial activity against Gram-negative bacteria. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-negative bacterium: Escherichia coli (MIC=10 M).##[Ref.11601906]Virus:##Frog Virus 3: 90% inhibition at 500 ?M;##Channel Catfish Virus: 90% inhibition at 50 ?M. No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found in the reference(s) presented Not found 11601906##10651828 Virology. 2001 Sep 30;288(2):351-7.##Eur J Biochem. 2000 Feb;267(3):894-900. "Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.##Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.##Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01516 GLFSILRGAAKFASKGLGKDLTKLGVDLVACKISKQC 37 "Esculentin-2B (Frogs, amphibians, animals)" P82839 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana berlandieri (Rio Grande leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=1 M);##Gram-negative bacterium: Escherichia coli (MIC=1 M).##Yeast: Candida albicans (MIC=29 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP02077 FLPIIAGIAAKVFPKIFCAISKKC 24 "Brevinin-1Pb (Frogs, amphibians, animals)" Q8QFQ5 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana pipiens (Northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=5 M);##Gram-negative bacterium: Escherichia coli (MIC=14 M).##Yeast: Candida albicans (MIC=7 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 10651828##12413397 Eur J Biochem. 2000 Feb;267(3):894-900.##Biochem J. 2003 Apr 1;371(Pt 1):125-130. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.##Chen T, Farragher S.M, Bjourson A.J, Orr D.F, Rao P, Shaw C." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.##Granular gland transcriptomes in stimulated amphibian skin secretions." DRAMP01830 FLPIVGKLLSGLL 13 "Temporin-1P (Temporin-1M; Temporin-1CSa; Frogs, amphibians, animals)" P82848 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana pipiens (Northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. PTM: Leucine amide at position 13." [Ref.10651828] Gram-positive bacterium: Staphylococcus aureus (MIC=110 ?M). [Ref.17451843] LC50 = 75 M against human erythrocytes. Cyclic Free \Amidation None L No cytotoxicity information found Not found 10651828##17451843 Eur J Biochem. 2000 Feb;267(3):894-900.##Peptides 2007; 28: 1268-1274. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.##Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.##Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group." DRAMP01151 GVGDLIRKAVSVIKNIV 17 "Uperin-3.5 (toads, amphibians, animals)" P82042 Not found Not found Uperoleia mjobergii (Australian toadlet) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Shows antibacterial activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Lactococcus lactis (MIC=3 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12.5 ?g/ml), Staphylococcus aureus (MIC=50 ?g/ml), Staphylococcus epidermidis (MIC=12.5 ?g/ml), Streptococcus uberis (MIC=12.5 ?g/ml).(Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L No cytotoxicity information found Not found PubMed ID is not available##15203252 Aust. J. Chem. 1996; 49:475-484.##Peptides. 2004 Jun;25(6):1035-1054. "Bradford AM, Raftery MJ, Bowie JH, Tyler MJ, Wallace JC, Adams GW, Severini C.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Novel uperin peptides from the dorsal glands of the australian floodplain toadlet Uperoleia inundata.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01152 GVIDAAKKVVNVLKNLP 17 "Uperin-3.6 (toads, amphibians, animals)" P82043 Not found Not found Uperoleia mjobergii (Australian toadlet) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix "In 50% (by vol.) trifluoroethanol, an NMR study and structure calculations indicate that uperin 3.6 adopts a well-defined amphipathic alpha-helix with distinct hydrophilic and hydrophobic faces.(Ref.1)" None Function: Shows antibacterial activity gaginst several Gram-positive bacteria. This peptide could inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). "Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Lactococcus lactis (MIC=3 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermidis (MIC=12.5 ?g/ml), Streptococcus uberis (MIC=12.5 ?g/ml).(Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L No cytotoxicity information found Not found 10461748##15203252 J Pept Res. 1999 Aug;54(2):137-145.##Peptides. 2004 Jun;25(6):1035-1054. "Chia BC, Carver JA, Mulhern TD, Bowie JH.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01153 GVIAAAKKVVNVLKNLF 17 "Ala4-uperin 3.6 (toads, amphibians, animals)" No entry found Not found Not found Uperoleia mjobergii (Australian toadlet) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Shows antibacterial activity gaginst several Gram-positive bacteria. "Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L No cytotoxicity information found Not found 10461748 J Pept Res. 1999 Aug;54(2):137-145. "Chia BC, Carver JA, Mulhern TD, Bowie JH." "The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii." DRAMP01154 GVIDAAAKVVNVLKNLF 17 "Ala7-uperin 3.6 (toads, amphibians, animals)" No entry found Not found Not found Uperoleia mjobergii (Australian toadlet) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Shows antibacterial activity gaginst several Gram-positive bacteria. "Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L No cytotoxicity information found Not found 10461748 J Pept Res. 1999 Aug;54(2):137-145. "Chia BC, Carver JA, Mulhern TD, Bowie JH." "The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii." DRAMP01155 GVIDAAKKVVNVLANLF 17 "Ala14-uperin 3.6 (toads, amphibians, animals)" No entry found Not found Not found Uperoleia mjobergii (Australian toadlet) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Shows antibacterial activity gaginst several Gram-positive bacteria. "Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L No cytotoxicity information found Not found 10461748 J Pept Res. 1999 Aug;54(2):137-145. "Chia BC, Carver JA, Mulhern TD, Bowie JH." "The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii." DRAMP01162 AGRGKQGGKVRAKAKTRSSRAGLQFPVGRVHRLLRKGNY 39 "Buforin-1 (Buforin I; Fragment of Histone H2A; toads, amphibians, animals)" P55897 Belongs to the histone H2A family Not found Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. PTM: Monoubiquitination of C-terminus gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties." "Gram-positive bacteria: Bacillus subtilis (MIC=4 ?g/ml), Staphylococcus aureus (MIC=4 ?g/ml), Streptococcus mutans (MIC=8 ?g/ml), Streptococcus pneumoniae (MIC=4 ?g/ml), Pseudomonas putida (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=4 ?g/ml), Serratia sp. (MIC=8 ?g/ml).##Fungi: Candida albicans (MIC=4 ?g/ml), Cryptococcus neoformans (MIC=4 ?g/ml), Saccharomyces cerevisiae (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free The residue at position 5 is N6-(2-hydroxyisobutyryl)lysine or N6-acetyllysine. The residue at position 9 is N6-(2-hydroxyisobutyryl)lysine or N6-lactoyllysine or N6-succinyllysine. The Lys13 has a interchain with G-Cter in ubiquitin. The Lys15 has a interchain with G-Cter in ubiquitin. The residue at position 36 is N6-(2-hydroxyisobutyryl)lysine. L No cytotoxicity information found DNA 8573171##8946958 Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.##FEBS Lett. 1996 Nov 25;398(1):87-90. "Park C.B, Kim M.S, Kim S.C.##Yi G.-S, Park C.B, Kim S.C, Cheong C." A novel antimicrobial peptide from Bufo bufo gargarizans.##Solution structure of an antimicrobial peptide buforin II. DRAMP01163 TRSSRAGLQFPVGRVHRLLRK 21 "Buforin-2 (Buforin II; Fragment of Histone H2A; toads, amphibians, animals)" P0DQL2 Belongs to the histone H2A family Not found Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed selective anticancer activity against 62 cancer cell lines (Lee 2008 Cancer Lett 271: 47-51). Buforin II is more potent than buforin I. PTM: Monoubiquitination of C-terminus gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties." "Gram-positive bacteria: Bacillus subtilis (MIC=2 ?g/ml), Staphylococcus aureus (MIC=4 ?g/ml), Streptococcus mutans (MIC=2 ?g/ml), Streptococcus pneumoniae (MIC=4 ?g/ml), Pseudomonas putida (MIC=2 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=1 ?g/ml), Serratia sp. (MIC=4 ?g/ml).##Fungi: Candida albicans (MIC=1 ?g/ml), Cryptococcus neoformans (MIC=1 ?g/ml), Saccharomyces cerevisiae (MIC=1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free The residue at position 21 is N6-(2-hydroxyisobutyryl)lysine L No cytotoxicity information found DNA 8573171##8946958 Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.##FEBS Lett. 1996 Nov 25;398(1):87-90. "Park C.B, Kim M.S, Kim S.C.##Yi G.-S, Park C.B, Kim S.C, Cheong C." A novel antimicrobial peptide from Bufo bufo gargarizans.##Solution structure of an antimicrobial peptide buforin II. DRAMP01164 GIGALSAKGALKGLAKGLAEHFAN 24 "Bombinin (toads, amphibians, animals)" P01505 Not found Not found Bombina variegata (Yellow-bellied toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial and hemolytic activities. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation. Caution: Residue 20 is assigned as E by similarity to other bombin sequences instead of Z (Glutamic acid or Gutamine) given " [Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=14 ?M). "[Ref.8223491] The lethal concentration (LC, the lowest concentration that inhibits growth) was over 50 M" Linear Free Amidation None L No cytotoxicity information found Not found PubMed ID is not available##8223491 Monatsh. Chem. 1970;101:182-189.##EMBO J. 1993; 12:4829-4832. "Csordas A, Michl H.##Mignogna G, Simmaco M, Kreil G, Barra D." Isolation and structural resolution of a haemolytically active polypeptide from the immune secretion of a European toad.##Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata. DRAMP01167 GILDAIKAIAKAAG 14 Hylaseptin-P1 (HSP1) P84292 Not found Not found Hyla punctata (Polka-dot tree frog) (Spotted tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Has antibacterial and antifungal activity. A weak hemolytic activity has been detected. "[Ref.14715660]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.1-8.0 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=48.8-64.0 ?g/ml), Escherichia coli ATCC 25922 (MIC=24.4-32.0 ?g/ml)." [Ref.14715660] HSP1 MIC concentration (256 g/mL = 195.2 M) produced 4.7% hemolysis against human erythrocytes. Linear Free [Ref.11297740] Free / [Ref.32828849] Amidation None L No cytotoxicity information found Not found 14715660##32828849 "J Biol Chem. 2004 Mar 26;279(13):13018-13026. ##Biochim Biophys Acta Biomembr . 2021 Jan 1;1863(1):183449. doi: 10.1016/j.bbamem.2020.183449. Epub 2020 Aug 21." "Prates MV, Sfora ML, Regis WC, Leite JR, Silva LP, Pertinhez TA, Ara?jo AL, Azevedo RB, Spisni A, Bloch C Jr.##Isabela P Gomes 1, Talita L Santos 1, Amanda N de Souza 1, Lcio O Nunes, Gabriele A Cardoso, Carolina O Matos, Lvia M F Costa, Luciano M Li?o, Jarbas M Resende, Rodrigo M Verly" The NMR-derived solution structure of a new cationic antimicrobial peptide from the skin secretion of the anuran Hyla punctata.##Membrane interactions of the anuran antimicrobial peptide HSP1-NH 2: Different aspects of the association to anionic and zwitterionic biomimetic systems DRAMP01170 NLVSGLIEARKYLEQLHRKLKNCKV 25 "Distinctin 2 (Frogs, amphibians, animals)" No entry found Not found Not found Phyllomedusa distincta (Tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Alpha helix (1 helices; 17 residues) Not found 1XKM resolved by NMR Comment: Distinctin is constituted of two different polypeptide chains connected by an intermolecular disulphide bridge. The entry is the chain 2 of Distinctin "Note: Distinctin chain 2 links to Distinctin chain 1 to form a heterodimeric peptide to exert antibacterial function. ##Gram-positive bacteria: Enterococcus faecalis (MIC=14.5 ?M), Staphylococcus aureus (MIC=28.0 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=28.0 ?M), Escherichia coli (MIC=14.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free There is an intermolecular disulphide bridge between Distinctin chain 1 (Cys19) and Distinctin chain 2 (Cys22). L No cytotoxicity information found Not found 11297740 FEBS Lett. 2001 Apr 6;494(1-2):85-89. "Batista CV, Scaloni A, Rigden DJ, Silva LR, Rodrigues Romero A, Dukor R, Sebben A, Talamo F, Bloch C." A novel heterodimeric antimicrobial peptide from the tree-frog Phyllomedusa distincta. DRAMP01174 GLLDFVTGVGKDIFAQLIKQI 21 "Ocellatin-4 (Frogs, amphibians, animals)" P85090 Not found Not found Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has hemolytic activity against human erythrocytes (HC50=14.3 ?M). Has antibacterial activity. Tissue specificity: Expressed by the skin dorsal glands." [Ref.17884127]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=64 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=64 ?M). [Ref.17884127] HC50 = 14.3 M against human O+ red blood cells Linear Free Amidation None L No cytotoxicity information found Not found 17884127 Toxicon 2007; 50: 1095-1104. Nascimento A et al Castro MS. "Purification, characterization and homology analysis of ocellatin 4, a cytolytic peptide from the skin secretion of the frog Leptodactylus ocellatus." DRAMP01177 GVVDILKGAAKDIAGHLASKVMNKL 25 "Ocellatin-F1 (Fallaxin; Frogs, amphibians, animals)" No entry found Not found Not found Leptodactylus fallax (Mountain chicken frog) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has low hemolytic activity of fallaxin (HC50>200 ?M). "[Ref.15544856]Gram-negative bacteria: Escherichia coli (MIC=40 ?M), Pseudomonas aeruginosa (MIC=80 ?M), Enterobacter cloacae (MIC=20 ?M), Klebsiella pneumoniae (MIC=80 ?M)." [Ref:15544856]HC50>200 M hemolytic activity of fallaxin Linear Free Amidation Free L [Ref.15544856]No cytotoxicity information found Not found 15544856 Regul Pept. 2005 Jan 15;124(1-3):173-178. "Rollins-Smith LA, King JD, Nielsen PF, Sonnevend A, Conlon JM." An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae). DRAMP01182 GLLDTLKGAAKNVVGSLASKVMEKL 25 "Ocellatin-P1 (Pentadactylin; Frogs, amphibians, animals)" No entry found Not found Not found Leptodactylus pentadactylus (South American bullfrog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Klebsiella pneumoniae KK3 9904 (MIC=100 ?M), Enterobacter cloacae HNTCC 53001 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus epidermidis RP62A (MIC=100 ?M), Streptococcus Group B HNTCC 80130 (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16236555]No cytotoxicity information found Not found 16236555 Comp Biochem Physiol C Toxicol Pharmacol. 2005 Aug;141(4):393-397. "King JD, Al-Ghaferi N, Abraham B, Sonnevend A, Leprince J, Nielsen PF, Conlon JM." Pentadactylin: an antimicrobial peptide from the skin secretions of the South American bullfrog Leptodactylus pentadactylus. DRAMP01184 GVLDILKGAAKDLAGHVATKVI 22 "SPX(1-22)(truncated peptide of Syphaxin; Frogs, amphibians, animals)" No entry found Not found Not found Leptodactylus syphax (Burgundy thin-toed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus ATCC 29213 (MIC=14.6 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=40.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17628627]No cytotoxicity information found Not found 17628627 Toxicon. 2007 Sep 15;50(4):572-580. "Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F." Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax. DRAMP01185 GVLDILKGAAKDLAGH 16 "SPX(1-16)(truncated peptide of Syphaxin; Frogs, amphibians, animals)" No entry found Not found Not found Leptodactylus syphax (Burgundy thin-toed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus ATCC 29213 (MIC=40.5 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.1 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17628627]No cytotoxicity information found Not found 17628627 Toxicon. 2007 Sep 15;50(4):572-580. "Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F." Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax. DRAMP01188 LALKSGGWLRLFGLKDKKH 19 "Chensinin-1ZHa (Frogs, amphibians, animals)" No entry found Not found Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=9 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=35 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.22943378]No cytotoxicity information found Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01189 ATNIPFKVHFRCKAAFC 17 "Andersonin-W1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC>47 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>47 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=47 ?g/ml)." [Ref:22029824] It has no hemolytic activity against human red blood cells Cyclic Free Cyclization (Cys12 and Cys17) Disulfide bond between Cys12 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01190 AVNIPFKVHFRCKAAFC 17 "Andersonin-W2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=20.2 ?g/ml)." [Ref:22029824] It has no hemolytic activity against human red blood cells Cyclic Free Cyclization (Cys12 and Cys17) Disulfide bond between Cys12 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01191 GLFSKFAGKGIVNFLIEGVE 20 "Andersonin-X1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.3 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30.5 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01192 FLPKLFAKITKKNMAHIR 18 "Andersonin-Y1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=3.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=1.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=1.6 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01194 TSRCIFYRRKKCS 13 "Andersonin-C1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Show hemolytic activity against human red blood cells and obvious insulin-stimulating activity at the concentration of 50 ??g/mL. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>120 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml)." [Ref:22029824] It has 15.22.1% hemolytic activity at 50g/ml against human red blood cells Cyclic Free Free Disulfide bond between Cys4 and Cys12. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01195 FIFPKKNIINSLFGR 15 "Andersonin-D1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Weakly active against bacteria and fungi. Andersonin-D1 showes obvious insulin-stimulating activity at the concentration of 50 ??g/mL. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>126 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=16 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=16 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01199 RFIYMKGFGKPRFGKR 16 "Hejiangin-A1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana hejiangensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Hejiangin-A1 showes killing effects against the tested strains. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=25 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=25 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01200 IPWKLPATFRPVERPFSKPFCRKD 24 "Hejiangin-F1 (frog, amphibians, animals)" No entry found Not found Not found Odorrana hejiangensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=100 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=100 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=100 ?g/ml)." [Ref:22029824]Non-hemolytic activity against human red blood cells Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01201 AAPRGGKGFFCKLFKDC 17 "Schmackerin-C1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana schmackeri "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Schmackerin-C1 showes killing effects against the tested strains. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=50 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=50 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys11 and Cys17) Disulfide bond between Cys11 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01202 GLLDFAKHVIGIASKLG 17 "Fallaxidin 3.2 (Frogs, amphibians, animals)" "B5LUQ7, B5LUR0, B5LUR1, B5LUQ3" Not found Not found Litoria fallax (Eastern dwarf tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Fallaxidin-3.2 shows antibacterial activity against the Gram-positive bacteria. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Enterococcus faecalis (MIC=100 ?M), Lactococcus lactis (MIC=500 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.18803332]No cytotoxicity information found Not found 18803332 Rapid Commun Mass Spectrom. 2008 Oct;22(20):3207-3216. "Jackway RJ, Bowie JH, Bilusich D, Musgrave IF, Surinya-Johnson KH, Tyler MJ, Eichinger PC." The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins. DRAMP01203 GLLDLAKHVIGIASKL 16 "Fallaxidin 3.1 (Frogs, amphibians, animals)" "B5LUQ8, B5LUQ3" Not found Not found Litoria fallax (Eastern dwarf tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Fallaxidin-3.1 shows antibacterial activity against the Gram-positive bacteria. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Enterococcus faecalis (MIC=100 ?M), Lactococcus lactis (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.18803332]No cytotoxicity information found Not found 18803332 Rapid Commun Mass Spectrom. 2008 Oct;22(20):3207-3216. "Jackway RJ, Bowie JH, Bilusich D, Musgrave IF, Surinya-Johnson KH, Tyler MJ, Eichinger PC." The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins. DRAMP01204 GLLSFLPKVIGVIGHLIHPPS 21 "Fallaxidin 4.1 (Frogs, amphibians, animals)" B5LUQ4 Not found Not found Litoria fallax (Eastern dwarf tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Fallaxidin-4.1 shows antibacterial activity against the Gram-positive bacteria. Inhibits the formation of NO by neuronal nitric oxide synthase (IC50=13.3 ?M). Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Lactococcus lactis (MIC=12 ?M), Micrococcus luteus (MIC=100 ?M), Staphylococcus epidermidis (MIC=100 ?M), Streptococcus uberis (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.18803332]No cytotoxicity information found Not found 18803332 Rapid Commun Mass Spectrom. 2008 Oct;22(20):3207-3216. "Jackway RJ, Bowie JH, Bilusich D, Musgrave IF, Surinya-Johnson KH, Tyler MJ, Eichinger PC." The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins. DRAMP01208 SIITMTKEAKLPQLWKQIACRLYNTC 26 "Pleurain-A1 (Pleurain A1; Frogs, amphibians, animals)" "A8DY01, A8DY00, A8DY02, A8DY03, A8DY04, A8DY09, A8DY10, A8DY15" Not found Not found Rana pleuraden (Yunnan pond frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has little hemolytic activity on red blood cells. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=30 ?g/ml);##Gram-positive bacteria: Bacillus dysenteriae (MIC=120 ?g/ml), Staphylococcus aureus ATCC 2592 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml).." [Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 g/ml Cyclic Free Cyclization (Cys20 and Cys26) Disulfide bond between Cys20 and Cys26. L No cytotoxicity information found Not found 17764786 Peptides. 2007 Oct;28(10):2069-2074. "Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K." A new family of antimicrobial peptides from skin secretions of Rana pleuraden DRAMP01209 SIITMTKEAKLPQSWKQIACRLYNTC 26 "Pleurain-A2 (Pleurain A2; Frogs, amphibians, animals)" A8B5P0 Not found Not found Rana pleuraden (Yunnan pond frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has little hemolytic activity on red blood cells. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=30 ?g/ml);##Gram-positive bacteria: Bacillus dysenteriae (MIC=60 ?g/ml), Staphylococcus aureus ATCC 2592 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml)." [Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 g/ml Cyclic Free Cyclization (Cys20 and Cys26) Disulfide bond between Cys20 and Cys26. L No cytotoxicity information found Not found 17764786 Peptides. 2007 Oct;28(10):2069-2074. "Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K." A new family of antimicrobial peptides from skin secretions of Rana pleuraden. DRAMP01214 FLGAIAAALPHVINAVTNAL 20 "Kassinatuerin-2Ma (Frogs, amphibians, animals)" No entry found Not found Not found Kassina maculata (African hyperoliid frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Alpha helix "Secondary structure prediction analysis revealed that virtually the entire structure of each kassinatuerin-2 related peptide is composed of alpha-helix, the helix was not amphipathic like many other amphibian skin antimicrobial peptides, in which there is a hydrophobic face and a positively charged faces the latter presumably interacting with the negatively charged glycocalyx of cell membranes." None "Function: Natural kassinatuerin-2Ma and their synthetic replicates possessed relatively potent growth inhibitory activity against the Gram-positive bacterium, S. aureus, but were ineffective against the Gram-negative bacterium, E. coli at concentrations up to 200 ?M and were relatively ineffective against the pathogenic yeast, C. albicans (120 ?M). Also possessed hemolytic activity as demonstrated using horse erythrocytes." [Ref.19427345]Gram-positive bacterium: Staphylococcus aureus (NCTC 10788) (MIC=16 ?M);##Gram-negative bacterium: Escherichia coli (NCTC 10418) (MIC>200 ?M) (MIC=120 ?M);##Yeast: Candida albicans (NCPF 1467) (MIC=120 ?M). "[Ref:19427345]18% hemolytic activity at 16 M, 45C50% hemolytic activity at 120 M against horse erythrocytes" Linear Free Amidation Free L [Ref.19427345]No cytotoxicity information found Not found 19427345 Peptides. 2009 Aug;30(8):1428-1433. "Wang L, Zhou M, McGrath S, Chen T, Gorman SP, Walker B, Shaw C." "A family of kassinatuerin-2 related peptides from the skin secretion of the African hyperoliid frog, Kassina maculata." DRAMP01218 GFMKYIGPLIPHAVKAISDLI 21 "Kassinatuerin-1 (Frogs, amphibians, animals)" P0C010 Not found Not found Kassina senegalensis (Senegal running frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Shows broad-spectrum antimicrobial activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-negative bacteria: Escherichia coli (MIC=6.25 ?M), Klebsiella pneumoniae (MIC=25 ?M), Enterobacter cloacae (MIC=6.25 ?M), Pseudomonas aeruginosa (MIC=25 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 ?M), Staphylococcus epidermidis (MIC=6.25 ?M), Enterococcus faecalis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15885852]Display cytotoxicity against L929 fibroblasts (LD50=12M). Not found 10679222##15885852 Biochem Biophys Res Commun. 2000 Feb 16;268(2):433-436.##Peptides. 2005 Nov;26(11):2104-2110. "Mattute B, Knoop FC, Conlon JM.##Conlon JM, Abraham B, Galadari S, Knoop FC, Sonnevend A, P?l T." "Kassinatuerin-1: a peptide with broad-spectrum antimicrobial activity isolated from the skin of the hyperoliid frog, Kassina senegalensis.##Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives." DRAMP01219 SLWENFKNAGKQFILNILDKIRCRVAGGCRT 31 "Palustrin-2LTa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Has antibacterial avctivity. "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.7 ?M), Bacillus licheniformis X39 (MIC=14 ?M), Psychrobacter faecalis X29 (MIC=1.7 ?M)." [Ref.22426384] It has hemolytic activities (LD50=220M) against human erythrocytes Cyclic Free Free Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01222 GFMDTAKNVAKNVAVTLIDKLRCKVTGGC 29 "Palustrin-2AJ1 (PL2AJ1; Frogs, amphibians, animals)" G3ETQ3 Not found Not found Amolops jingdongensis (Chinese torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Has hemolytic activity, low cytotoxicity and low antioxidant activity. Tissue specificity: Expressed by the skin glands. PTM: One disulfide bond (C23-C29) and Cleavage on pair of basic residues." "[Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=20 ?M), Enterococcus faecalis ATCC29212 (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=13 ?M), Bacillus pyocyaneus CMCCB1010 (MIC=20 ?M), Pseudomonas aeruginosa ATCC27853 (MIC=33 ?M), Bacillus dysenteriae (MIC=50 ?M)." [Ref:21816202] IC50=135 M against human and rabbit erythrocytes Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L [Ref.21816202] Cytotoxicity: the K562 (IC50=58M) and HT29 mammalian cell lines(IC50=57M). Not found 21816202 Biochimie. 2012 Feb;94(2):328-334. "Chen Z, Yang X, Liu Z, Zeng L, Lee W, Zhang Y." "Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis." DRAMP01227 ALFSILRGLKKLGNMGQAFVNCKIYKKC 28 "Palustrin-1b (Frogs, amphibians, animals)" P84275 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys22 and Cys28) Disulfide bond between Cys22 and Cys28. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01228 ALSILRGLEKLAKMGIALTNCKATKKC 27 "Palustrin-1c (Frogs, amphibians, animals)" "P84276, A7WNV8" Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial activity against Gram-negative bacteria E. coli. Possesses insulin-releasing activity. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=28 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys21 and Cys27) Disulfide bond between Cys21 and Cys27. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01229 ALSILKGLEKLAKMGIALTNCKATKKC 27 "Palustrin-1d (Frogs, amphibians, animals)" P84277 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=28 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys21 and Cys27) Disulfide bond between Cys21 and Cys27. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01231 GFFSTVKNLATNVAGTVIDTLKCKVTGGCRS 31 "Palustrin-2b (Frogs, amphibians, animals)" "P84279, D3UA82" Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=78 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01232 GFMDTAKNVAKNVAATLLDKLKCKITGGC 29 "Palustrin-2ISc (Frogs, amphibians, animals)" G3XHN9 Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?M), Bacillus subtilis (MIC=12.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21867685 Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-677. "Iwakoshi-Ukena E, Soga M, Okada G, Fujii T, Sumida M, Ukena K." Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning. DRAMP01233 GFLSTVKNLATNVAGTVIDTLKCKVTGGCRS 31 "Palustrin-2c (Frogs, amphibians, animals)" P84280 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=120 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01234 GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLNNIGNTGCNEDEC 48 "Palustrin-3a (Frogs, amphibians, animals)" P84281 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=1 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys43 and Cys48) Disulfide bond between Cys43 and Cys48. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01235 GIFPKIIGKGIKTGIVNGIKSLVKGVGMKVFKAGLSNIGNTGCNEDEC 48 "Palustrin-3b (Frogs, amphibians, animals)" P84262 Not found Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=1 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys43 and Cys48) Disulfide bond between Cys43 and Cys48. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01237 GFMDTAKNVAKNVAVTLLDKLKCKITGGC 29 "Palustrin-2ISa (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana ishikawae "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?M), Staphylococcus aureus (MRSA) (MIC=100 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01238 GLWNSIKIAGKKLFVNVLDKIRCKVAGGCKTSPDVE 36 "Palustrin-2SIb (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana ishikawae "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), S. aureus (MRSA) (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K.2011." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-2 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP01244 FFPIGVFCKIFKTC 14 "Japonicin-1 (Frogs, amphibians, animals)" P83305 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana japonica (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin dorsal glands. Gram-negative bacterium: Escherichia coli (MIC=30 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys8 and Cys14) Disulfide bond between Cys8 and Cys14. L No cytotoxicity information found Not found 11835990 Peptides. 2002;23:419-425 "Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM." Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica. DRAMP01245 FFPLALLCKVFKKC 14 "Japonicin-1CDYa (Frogs, amphibians, animals)" B3VZU2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Antimicrobial peptide. Lacks hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." [Ref.19539775]Gram-positive bacterium: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:19539775] HC50>300 M against human red blood cells Cyclic Free Cyclization (Cys8 and Cys14) Disulfide bond between Cys8 and Cys14. L No cytotoxicity information found Not found 19539775 Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178. "Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH." "Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii." DRAMP01246 FGLPMLSILPKALCILLKRKC 21 "Japonicin-2 (Frogs, amphibians, animals)" P83306 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana japonica (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=20 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys21) Disulfide bond between Cys14 and Cys21. L No cytotoxicity information found Not found 11835990 Peptides. 2002;23:419-425. "Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM." Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica. DRAMP01248 FLIGMTHGLICLISRKC 17 "Dybowskin-1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Dybowskin-1 has low hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=12.5 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=50 ?g/ml), Staphylococcus epidermidis ATCC 12228 (MIC=60 ?g/ml)." [Ref:17698251] It has 0.99% hemolytic activity at 100 g/ml against huamn red blood cells Cyclic Free Cyclization (Cys11 and Cys17) Disulfide bond between Cys11 and Cys17. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01249 FLIGMTQGLICLITRKC 17 "Dybowskin-2 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Dybowskin-2 has hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=15 ?g/ml), Bacillus subtilis ATCC6633 (MIC=25 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=25 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 ?g/ml), Escherichia coli KCTC2433 (MIC=60 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=60 ?g/ml), Proteus mirabilis ATCC25933 (MIC>100 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=100 ?g/ml)." [Ref:17698251] It has 10.99% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys11 and Cys17) Disulfide bond between Cys11 and Cys17. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01250 GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC 33 "Dybowskin-3 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Dybowskin-3 has hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=39 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=50 ?g/ml), Bacillus subtilis ATCC6633 (MIC=60 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=60 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=15 ?g/ml), Escherichia coli KCTC2433 (MIC=15 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC>100 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=100 ?g/ml)." [Ref:17698251] It has 1.86% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01251 VWPLGLVICKALKIC 15 "Dybowskin-4 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Dybowskin-4 has relatively greater hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=1.56 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=3.13 ?g/ml), Bacillus subtilis ATCC6633 (MIC=6.25 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=30 ?g/ml), Escherichia coli KCTC2433 (MIC=15 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=25 ?g/ml)." [Ref:17698251] It has 47.58% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys9 and Cys15) Disulfide bond between Cys9 and Cys15. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01252 GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC 38 "Dybowskin-5 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Dybowskin-5 has hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=50 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 ?g/ml), Escherichia coli KCTC2433 (MIC=60 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=50 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=50 ?g/ml)." [Ref:17698251] It has 17.84% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01253 FLPLLLAGLPLKLCFLFKKC 20 "Dybowskin-6 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Dybowskin-6 has relatively greater hemolytic activity against human red blood cells (hRBCs). "Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=12.5 ?g/ml), Bacillus subtilis ATCC6633 (MIC=50 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 ?g/ml).##Yeast: Candida albicans (MIC=50 ?g/ml)." [Ref:17698251] It has 59.39% hemolytic activity at 100 g/ml against huamn red blood cells Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found [Ref:17698251]59.39% hemolytic activity at 100 g/ml against huamn red blood cells 17698251 Peptides. 2007 Aug;28(8):1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01254 IIPLPLGYFAKKT 13 "Dybowskin-1CDYa (Frogs, amphibians, animals)" B5A9S9 Not found Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Tissue specificity: Expressed by the skin glands. Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M);##Gram-negative bacterium: Escherichia coli (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19539775]No cytotoxicity information found Not found 19539775 Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178. "Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH." "Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii." DRAMP01255 SAVGRHGRRFGLRKHRKH 18 "Dybowskin-2CDYa (Chensinin-1; Frogs, amphibians, animals)" B5A9T1 Not found Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Antimicrobial peptide. Has activity against the Gram-positive bacteria: S. aureus and the Gram-negative bacteria E. coli. Lacks hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.19539775] Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-negative bacterium: Staphylococcus aureus (MIC=6 ?M).##[Ref.19341344] Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 ?M), Bacillus cereus (MIC=14.4 ?M), Streptococcus lactis (MIC=14.4 ?M)." [Ref:19539775]HC50>300 M against human red blood cells Linear Free Free Free L [Ref.19539775]No cytotoxicity information found##[Ref.19341344]No cytotoxicity information found Not found 19539775##19341344 Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.##Zoolog Sci. 2009 Mar;26(3):220-226. "Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.##Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y." "Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.##Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis." DRAMP01257 GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV 33 "Dermadistinctin-K (DD K; Frogs, amphibians, animals)" P83638 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix Not found "2K9B, 2JX6 resolved by NMR." "Function: Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=4.7 ?M), Enterococcus faecalis (MIC>19 ?M);Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2.4 ?M), Escherichia coli (MIC=0.6 ?M).##Fungi: Candida tropicalis (MIC=10.1 ?M), Candida guilliermondii (MIC=20.3 ?M), Candida albicans (MIC=20.3 ?M), Candida albicans ATCC 1023 (MIC=10.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]No cytotoxicity information found liposomes 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01258 ALWKTLLKNVGKAAGKAALNAVTDMVNQ 28 "Dermadistinctin-L (DD L; Frogs, amphibians, animals)" P83639 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix Not found None "Function: Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes. Show little hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." "[Ref.10477123]Gram-positive bacteria: Staphylococcus aureus (MIC=1.3 ?M), Enterococcus faecalis (MIC=10 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=40 ?M), Escherichia coli (MIC=2.5 ?M);##[Ref.17442605]Fungi: Candida tropicalis (MIC=10.9 ?M), Candida guilliermondii (MIC=21.8 ?M), Candida albicans (MIC=21.8 ?M), Candida albicans ATCC 1023 (MIC=10.9 ?M)." [Ref:10477123]Show some hemolytic starting at 12.5 M against human blood Linear Free Free Free L [Ref.10477123]No cytotoxicity information found liposomes 10477123##12379643##17409003##17442605 Peptides. 1999;20(6):679-686.##J Biol Chem. 2002 Dec 20;277(51):49332-49340.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):329-335.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):336-343. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr.##Brand GD, Leite JR, Silva LP, Albuquerque S, Prates MV, Azevedo RB, Carregaro V, Silva JS, S?? VC, Brand??o RA, Bloch C Jr.##Silva LP, Leite JR, Brand GD, Regis WB, Tedesco AC, Azevedo RB, Freitas SM, Bloch C Jr.##Leite JR, Brand GD, Silva LP, K??ckelhaus SA, Bento WR, Ara??jo AL, Martins GR, Lazzari AM, Bloch C Jr." "Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: liposomes fusion and/or lysis investigated by fluorescence and atomic force microscopy.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity." DRAMP01259 ALWKTMLKKLGTMALHAGKAAFGAAADTISQ 31 "Dermadistinctin-M (DD M; Frogs, amphibians, animals)" P83640 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Amphibian defense peptide. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=38 ?M), Enterococcus faecalis (MIC>38 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=38 ?M), Escherichia coli (MIC=9.7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]No cytotoxicity information found Not found 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01260 ALWKNMLKGIGKLAGQAALGAVKTLVGAES 30 "Dermadistinctin-Q1 (DD Q1; Frogs, amphibians, animals)" P83641 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Amphibian defense peptide. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=2.7 ?M), Enterococcus faecalis (MIC=22 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=5.4 ?M), Escherichia coli (MIC=1.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]No cytotoxicity information found Not found 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01261 GLWSKIKEAAKTAGLMAMGFVNDMV 25 "Dermadistinctin-Q2 (DD Q2; Frogs, amphibians, animals)" P83642 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Amphibian defense peptide. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=22 ?M), Enterococcus faecalis (MIC=11 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=22 ?M), Escherichia coli (MIC=5.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]To produce hemolysis more than 38 M peptide concentrations was required. Not found 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01288 FLSLIPHIVSGVASIAKHF 19 "Phylloseptin-1 (PSN-1; Frogs, amphibians, animals)" E3PQH3 Not found PSN-1 Phyllomedusa sauvagei (Sauvage's leaf frog) "Antimicrobial, Antibacterial, Antifungal" Homology Not found Not found None Function: PSN-1 displayed broad-spectrum activity against a range of planktonic organisms. "S. aureus (MIC=5 ?M), Escherichia coli and Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.20451254]No cytotoxicity information found Not found 20451254 Mol Immunol. 2010 Jul;47(11-12):2030-2037. "Zhang R, Zhou M, Wang L, McGrath S, Chen T, Chen X, Shaw C." Phylloseptin-1 (PSN-1) from Phyllomedusa sauvagei skin secretion: a novel broad-spectrum antimicrobial peptide with antibiofilm activity. DRAMP01301 FLSLIPHAINAVSAIAKHN 19 "Phylloseptin-1 (PS-1; Frogs, amphibians, animals)" P84566 Not found psn1 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (1 helices; 14 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JQ0 resolved by NMR. "Function: Atomic force microscopy experiments indicated that the bacteriolytic properties of these peptides might be related to their disruptive action on the cell membrane. PS-1 did not exhibit significant hemolytic activity on human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.15752569]Gram-positive bacteria: Staphylococcus aureus (MIC=7.9 ?M), Enterococcus faecalis (MIC=4.0 ?M);##Gram-negative bacteria: Escherichia coli (MIC=7.9 ?M), Psecdomonas aeruginosa (MIC=4 ?M), Psecdomonas aeruginosa wt (MIC=3 ?M)." "[Ref:15752569]0.3% hemolytic activity at 4 M, 0.57% hemolytic activity at 8 M, 0.6% hemolytic activity at 16 M, 0.98% hemolytic activity at 32 M, 1.98% hemolytic activity at 64 M against human red blood cells" Linear Free Amidation Free L [REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01302 FLSLIPHAINAVSTLVHHF 19 "Phylloseptin-2 (PS-2; Frogs, amphibians, animals)" "P85881, P84567, Q0VZ43" Not found psn2 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 14 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JPY resolved by NMR. "Function: Has antimicrobial activity. PS-2 did not exhibit significant hemolytic activity on human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.18656510][ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=15.1 ?M);##Gram-negative bacteria: Escherichia coli (MIC=60.4 ?M), Klebsiella pneumoniae (MIC=60.4 ?M), Pseudomonas aeruginosa (MIC=60.4 ?M);##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=7.6 ?M), S. agalactiae (MIC=1.9 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=60.4 ?M), A. calcoaceticus (MIC=3.7 ?M);##Fungi: Candida albicans (MIC=15.1 ?M)." "[Ref:15752569]0.1% hemolytic activity at 4 M, 0.28% hemolytic activity at 4 M, 0.7% hemolytic activity at 8 M, 0.8% hemolytic activity at 16 M, 1.05% hemolytic activity at 32 M, 2.05% hemolytic activity at 64 M against human red blood cells" Linear Free Amidation Free L [REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01303 FLSLIPHAINAVSALANHG 19 "Phylloseptin-3 (PS-3; Frogs, amphibians, animals)" P84568 Not found psn3 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 11 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JQ1 resolved by NMR. "Function: Has antimicrobial activity (By similarity). Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=32.9 ?M);##Gram-negative bacteria: Escherichia coli (MIC=65.6 ?M), Klebsiella pneumoniae (MIC=65.6 ?M), Pseudomonas aeruginosa (MIC=65.6 ?M). NOTE: Initial inoculum of 108 cells/Ml.##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=8.2 ?M), S. agalactiae (MIC=4.1 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=32.8 ?M), A. calcoaceticus (MIC=4.1 ?M).##Fungi: Candida albicans (MIC=8.2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01305 FLSLIPHAINAVSAIAKHFG 20 "Phylloseptin-7 (PS-7; Frogs, amphibians, animals)" "P84572, Q0VZ42" Not found psn7 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-negative bacteria E. coli and P. aeruginosa, and the Gram-positive bacteria: S. aureus. No hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.16963159]Gram-negative bacteria: Escherichia coli (MIC=6 ?M), Pseudomonas aeruginosa (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M)" [Ref:16963159]Non-hemolytic activity at 6 M against human erythrocytes Linear Free Amidation Free L [Ref.16713656]No cytotoxicity information found Not found 16963159##16713656 Peptides. 2006 Dec;27(12):3092-3999.##Peptides. 2006 Sep;27(9):2129-2136. "Concei???o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC.##Chen T, Zhou M, Gagliardo R, Walker B, Shaw C." "Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis.##Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis." DRAMP01306 FLSLIPHAINAVSAIAKHF 19 "Phylloseptin-7 (PS-7; Frogs, amphibians, animals)" P85882 Not found Not found Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity but does not inhibit the growth of the fungus C. albicans. Tissue specificity: Expressed by the skin glands. PTM: Phenylalanine amide at F19." "Gram-negative bacterium: Escherichia coli ATCC 11775 (MIC=7.2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (MIC=3.6 ?M), Micrococcus luteus ATCC 49732 (MIC=1.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16963159]No cytotoxicity information found##[Ref.17553595]No cytotoxicity information found Not found 17553595##16963159 Peptides. 2007 Jul;28(7):1331-1343.##Peptides. 2006 Dec;27(12):3092-3099. "Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.##Concei??o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC." A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.##Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis. DRAMP01314 FLSLLPSIVSGAVSLAKKLG 20 "Phylloseptin 12 (PS-12; Frogs, amphibians, animals)" Q17UY9 Not found psn-12 Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium M. luteus. Does not inhibit the growth of the fungus C. albicans. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." Gram-positive bacterium: Micrococcus luteus ATCC 49732 (MIC=1.3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17553595]No cytotoxicity information found Not found 17553595 Peptides. 2007 Jul;28(7):1331-1343. "Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S." A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea. DRAMP01319 RRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA 48 "Cathelicidin-AL (Gly-rich; Frogs, amphibians, animals)" No entry found Not found Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=6.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 ?g/ml), Bacillus subtilis (MIC=100 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 ?g/ml), Psecdomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Psecdomonas aeruginosa ATCC27853 (MIC=6.25 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22009138]No cytotoxic against HUVEC or RMMCs at the concentration of 0.4 mg/ml. Not found 22009138 Amino Acids. 2012 Aug;43(2):677-685. "Hao X, Yang H, Wei L, Yang S, Zhu W, Ma D, Yu H, Lai R." Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate. DRAMP01320 AAFRGCWTKNYSPKPCL 17 "Ranacyclin-B-AL1 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops loloensis (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Has antibacterial activity. "Gram-positive bacteria: Staphylococcus aureus (MIC=51 ?M), Bacillus subtilis (MIC=26 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP01339 FLPIVGKLLSGLSGLL 16 "Amolopin-2a (Frogs, amphibians, animals)" No entry found Not found Not found Amolops loloensis (Rufous-spotted torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus (MIC=2.00 ?g/ml), Bacillus dysenteriae (MIC=1.50 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=3.00 ?g/ml).##Candida albicans (MIC=6.50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17000029]Display cytotoxicity against HepG2(IC50=77 mg/ml). Not found 17000029 Peptides. 2006 Dec;27(12):3085-3091. "Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R." "Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis." DRAMP01341 FLPLAVSLAANFLPKLFCKITKKC 24 "Amolopin-1b (Frogs, amphibians, animals)" A0SN42 Not found Not found Amolops loloensis (Rufous-spotted torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus (MIC=5.50 ?g/ml), Bacillus dysenteriae (MIC=2.20 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=6.50 ?g/ml).##Yeast: Candida albicans (MIC=7.50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys18 and Cys24) Disulfide bridge between Cys18 and Cys24. L [Ref.17000029]Display cytotoxicity against HepG2(IC50=58 mg/ml). Not found 17000029 Peptides. 2006 Dec;27(12):3085-3091. "Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R." "Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis." DRAMP01346 VIGSILGALASGLPTLISWIKNR 23 "Prepromelittin-related peptide (Frogs, amphibians, animals)" A7BJK5 Not found prMRP Rana sakuraii (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).##Yeast: Candida albicans (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17174009]No cytotoxicity information found##[Ref.17826868]No cytotoxicity information found Not found 17174009##17826868 Peptides. 2007;28(3):505-514.##Peptides. 2007 Oct;28(10):2061-2068. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Suzuki H, Conlon JM, Iwamuro S." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.##Evidence that the genes encoding the melittin-related peptides in the skins of the Japanese frogs Rana sakuraii and Rana tagoi are not orthologous to bee venom melittin genes: developmental- and tissue-dependent gene expression. DRAMP01347 AIGSILGALAKGLPTLISWIKNR 23 "Prepromelittin-related peptide (Frogs, amphibians, animals)" A7BJK6 Not found prMRP Rana tagoi (Tago frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix Not found 6dst resolved by NMR (related PDB_ID) Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Antifungal activity against C. albicans. "[Ref.12804591]Gram-positive bacterium: Staphylococcus aureus (MIC=3.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=20 ?M).##Yeast: Candida albicans (MIC=19 ?M).##EL4 T-lymphoma cells (MIC=14 ?M).##[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=6.25 M), Staphylococcus epidermidis (MIC=3.13 M), Bacillus subtilis (MIC=3.13 M);##Gram-negative bacteria : Escherichia coli (MIC=25 M), Pseudomonas aeruginosa (MIC=12.5 M), Klebsiella pneumoniae (MIC=12.5 M)" [Ref.27271216] 100% hemolysis at 20 M against human red blood cells Linear Free Amidation Free L [Ref.12804591]Display cytotoxic against L929 fibroblasts(LC50=20 M);EL4 T-lymphoma cells(LC50=14 M).##[Ref.27271216]L929 cells:Cell viability is approximately 10% at the concentration of 6.25?M. Not found 12804591##17174009##27271216 Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.##Peptides. 2007;28(3):505-514.##Sci Rep. 2016 Jun 8;6:27394. "Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pl T##Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji" "A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties##Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii##Design of an -helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity" DRAMP01350 FCTMIPIPRCY 11 "Tigerinin-1 (Frogs, amphibians, animals)" P82651 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=30 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=30 ?g/ml), Micrococcus luteus MT 166 (MIC=20 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=40 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=40 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=80 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys2 and Cys10. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01351 RVCFAIPLPICH 12 "Tigerinin-2 (Frogs, amphibians, animals)" P82652 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=20 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=40 ?g/ml), Micrococcus luteus MT 166 (MIC=20 ?g/ml).##Gram-negative bacteria: Pseudomonas putida NCIM 2102 (MIC=50 ?g/ml), Escherichia coli (MIC=50 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01352 RVCYAIPLPICY 12 "Tigerinin-3 (Frogs, amphibians, animals)" P82653 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=30 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=30 ?g/ml), Micrococcus luteus MT 166 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=40 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=40 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=80 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01353 RVCYAIPLPIC 11 "Tigerinin-4 (Frogs, amphibians, animals)" P82654 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand-turn Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacterium: Staphylococcus aureus ATCC 8530 (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=60 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=60 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation;Cyclization (Cys3 and Cys11) Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01354 LVRGCWTKSYPPKPCFVR 18 "Peptide leucine arginine (pLR; Frogs, amphibians, animals)" "Q90WP7, P82110" Not found Not found Rana pipiens (Northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide. Antiproliferative activity against human breast and ovarian tumor cell lines in vitro. Inhibits granulopoiesis in rat in vitro. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against Gram-positive bacteria: B.megaterium Bm11, S. lentus and M.luteus, and antifungal activity against C.tropicalis, C.guiller-mondii and P.nicotianae spores. Has hemolytic activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores." "[Ref.11099505]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=20 ?M), Staphylococcus lentus (MIC=50 ?M), Micrococcus luteus (MIC=10 ?M);##Fungi: Candida tropicalis (MIC=11 ?M), Candida guillermondii (MIC=6.6 ?M), Phytophthora nicotianae spores (MIC=75 ?M)." [Ref:11099505] It has 2.5% hemolytic activity at 100 M against human red blood Cyclic Free Free Disulfide bond between Cys5 and Cys15. L No cytotoxicity information found Not found 11099505 J. Biol. Chem. 2001;276:10145-10152. "Salmon A.L, Cross L.J.M, Irvine A.E, Lappin T.R.J, Dathe M, Krause G, Canning P, Thim L, Beyermann M, Rothemund S, Bienert M, Shaw C." "Peptide leucine arginine, a potent immunomodulatory peptide, isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens." DRAMP01355 FLGGLIKIVPAMICAVTKKC 20 "Ranalexin (Frogs, amphibians, animals)" P39084 Not found Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations. Tissue specificity: Expressed by the skin dorsal glands. Developmental stage: Expression starts at metamorphosis and continues into adulthood. PTM: Contains one disulfide bond 14-20." "Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=32 ?g/ml), Pseudomonas aeruginosa (MIC=128 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 8144672##9578480 J Biol Chem. 1994 Apr 8;269(14):10849-10855.##Eur J Biochem. 1998 Apr 1;253(1):221-228. "Clark DP, Durell S, Maloy WL, Zasloff M.##Vignal E, Chavanieu A, Roch P, Chiche L, Grassy G, Calas B, Aumelas A." "Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.##Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles." DRAMP03024 LKLKSIVSWAKKVL 14 "Mastoparan B (MP-B; insects, arthropods, invertebrates, animals)" P21654 Not found Not found Vespa basalis (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti Mammalian cells, Anti-cancer" Not found Alpha helix Tryptophan residue in MP None Function: Mast cell degranulating peptide. Activates G proteins that couple to phospholipase C. Has hemolytic activity. "[Ref.10667861] Gram-positive bacteria: Staphylococcus epidermidis ATTC 12228 (MIC=25 ?M), Bacillus subtilis PCI 219 (MIC=25 ?M), Enterococcus faecium EFMY-28 (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli NIHJ JC-2 (MIC=50 ?M)" "[Ref.10667861] 68.2% hemolysis at the peptide concentration of 100 ?M is , 27.9% Hemolysis at 50 ?M against human red blood cells." Linear Free Amidation Free L [Ref.10667861]No cytotoxicity information found##[Ref.8555423]No cytotoxicity information found Not found 10667861##8555423 J Pept Res. 2000 Jan;55(1):51-62.##Biopolymers. 1995 Dec;36(6):793-801 "Yu K, Kang S, Park N, Shin J, Kim Y.##Park NG, Yamato Y, Lee S, Sugihara G1995" Relationship between the tertiary structures of mastoparan B and its analogs and their lytic activities studied by NMR spectroscopy.##Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity DRAMP01358 FLGGLFKLVPSVICAVTKKC 20 "Ranalexin-Vb (Frogs, amphibians, animals)" No entry found Not found Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=12 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 15996769 Regul Pept 2005; 131: 38-45. Conlon JM et al Bevier CR. "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP01359 FLGGLMKIIPAAFCAVTKKC 20 "Ranalexin-1G (Frogs, amphibians, animals)" No entry found Not found Not found Rana grylio (North American pig frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None "Function: Has growth-inhibitory activity against the gram-positive bacterium Staphylococcus aureus, the gram-negative bacterium Escherichia coli and the yeast, Candida albicans." Gram-negative bacterium: Escherichia coli (MIC=9 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=18 ?M).##Yeast: Candida albicans (MIC=70 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 10828493 Regul Pept. 2000 Jun 30;90(1-3):53-60. "Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM." Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio. DRAMP01360 GLLDALSGILGL 12 "Frenatin-1 (Frogs, amphibians, animals)" P82021 Not found Not found Litoria infrafrenata (Giant tree frog) (White-lipped tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Wide spectrum antimicrobial peptide. Considered to interact with the outer lipid layer of the bacterial cell, penetrate the bacterial membrane, form ion channels, and ultimately kill the cell. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. PTM: C-terminal amidation." Gram-positive bacteria: Micrococcus luteus (MIC=25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.9225251]No cytotoxicity information found Not found 9225251 J Pept Sci. 1996 Mar-Apr;2(2):117-124. "Raftery MJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata. DRAMP01361 GLLGTLGNLLNGLGL 15 "Frenatin-2 (Frogs, amphibians, animals)" P82022 Not found Not found Litoria infrafrenata (Giant tree frog) (White-lipped tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Wide spectrum antimicrobial peptide. Considered to interact with the outer lipid layer of the bacterial cell, penetrate the bacterial membrane, form ion channels, and ultimately kill the cell. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. PTM: C-terminal amidation." Gram-positive bacteria: Micrococcus luteus (MIC=50 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.9225251]No cytotoxicity information found Not found 9225251 J Pept Sci. 1996 Mar-Apr;2(2):117-124. "Raftery MJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata. DRAMP01362 GLMSVLGHAVGNVLGGLFKS 20 "Frenatin-3 (Frogs, amphibians, animals)" P56249 Not found Not found Litoria infrafrenata (Giant tree frog) (White-lipped tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Wide spectrum antimicrobial peptide. Considered to interact with the outer lipid layer of the bacterial cell, penetrate the bacterial membrane, form ion channels, and ultimately kill the cell. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." "Gram-negative bacterium: Escherichia coli (MIC=50 ?g/ml);##Gram-positive bacteria: Leuconostoc mesenteroides (MIC=25 ?g/ml), Bacillus cereus (MIC=12.5 ?g/ml), Micrococcus luteus (MIC=1.5 ?g/ml), Pastewella haemolytica (MIC=0.8 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.9225251]No cytotoxicity information found Not found 9225251 J Pept Sci. 1996 Mar-Apr;2(2):117-124. "Raftery MJ, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata. DRAMP01364 GLFGVLAKVAAHVVPAIAEHF 21 "Maculatin-1.1 (Frogs, amphibians, animals)" P82066 Not found Not found Litoria genimaculata (Green-eyed tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Alpha helix Not found None "Function: Maculatin-1.1 shows significant antibacterial activity against Gram-positive bacteria, less against Gram-negative bacteria. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Bacillus cereus (MIC=3 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=3 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=11.3 M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Not found 16140737##9620615##15203252 J Virol. 2005 Sep;79(18):11598-606. ##J Pept Sci. 1998 Apr;4(2):111-115.##Peptides. 2004; 25: 1035-1054. "VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. ##Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01367 GLLGLLGSVVSHVLPAITQHL 21 "Maculatin-1.4 (frog, amphibia, animals)" No entry found Not found Not found Litoria eucnemis (Australian anurans) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: Shows antibacterial activity against the Gram-positive bacteria. PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Bacillus cereus (MIC=6 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=50 ?g/ml), Staphylococcus aureus (MIC=50 ?g/ml), Staphylococcus epidermidis (MIC=50 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252 Peptides. 2004 Jun; 25: 1035-1054. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01368 GFVDFLKKVAGTIANVVT 18 "Maculatin-2.1 (Frogs, amphibians, animals)" P82068 Not found Not found Litoria genimaculata (brown-spotted treefrog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Shows antibacterial activity against the Gram-positive bacteria. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Micrococcus luteus (MIC=100 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermidis (MIC=50 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml). (Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found##[Ref.9620615]No cytotoxicity information found Not found 9620615##15203252 J Pept Sci. 1998 Apr;4(2):111-115.##Peptides. 2004; 25: 1035-1054. "Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01370 MLCKLSMFGAVLGVPACAIDCLPMGKTGGSCEGGVCGCRKLTFKILWDKKFG 52 "Oh-defensin (O. hainana defensin; spiders, animals)" No entry found Not found Not found Ornithoctonus hainana (Venoms) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial and antifungal activities. "Gram-positive bacteria: Staphylococcus aureus (MIC=1.25 ?g/ml), Bacillus cereus (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=1.25 ?g/ml), Bacillus dysenteriae (MIC=1.25 ?g/ml), Pseudomonas aeruginosa (MIC=5 ?g/ml).##Yeast: Candida albicans (MIC=1.25 ?g/ml)." "[Ref.21538709] It has little hemolytic activity, inducing 7% hemolysis at the concentration up to 200 ?g/ml (about 36 ?M)." Cyclic Free Free Has three disulfide bonds L No cytotoxicity information found Not found 21538709 J Pept Sci. 2011 Jul;17(7):540-544. "Zhao H, Kong Y, Wang H, Yan T, Feng F, Bian J, Yang Y, Yu H." "A defensin-like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana." DRAMP01371 GLLSGILGAGKHIVCGLTGCAKA 23 "Odorranain-NR (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Combine helix and strand structure "Odorranain-NR has a large proportion of beta-sheet. In Tris HCl + SDS, odorranain-NR has a major conformation of beta-sheet (79.2%) and a minor conformation of beta-turn (1.3%). In Tris HCl, the beta-sheet has been decreased to 57.1% and the beta-turn has been increased to 10.5%. The beta-sheet has been decreased to 39.8% in water." None "Function: Odorranain-NR exhibits antimicrobial activity against the tested strains except E. coli ATCC25922. Odorranain-NR has little hemolytic activity on red blood cells even with peptide concentration up to 100 mg/ml. PTM: Odorranain-NR has an intramolecular disulfide-bridged hexapeptide segment, which is a new type of disulfide-bridge motif in amphibian antimicrobial peptides." "[Ref.18282640]Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=9.375 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 ?g/ml), Bacillus dysenteriae (MIC=37.5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=18.75 ?g/ml)." [Ref:18282640] It has little hemolytic activity at 100 g/ml against rabbit red blood cells Cyclic Free Free Disulfide bond between Cys15 and Cys20. L No cytotoxicity information found Not found 18282640 Peptides. 2008 Apr;29(4):529-535. Che Q et al Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami. DRAMP00931 TCSYTMEA 8 Antimicrobial peptide 3 (Cn-AMP3; Plant defensin) P86707 Not found Not found Cocos nucifera (Coconut palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level). Subunit structure: Monomer." [Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=257 g/ml) and Staphylococcus aureus (MIC=274 g/ml);##Gram-negative bacteria: Escherichia coli (MIC=302 g/ml) and Pseudomonas aeruginosa (MIC=259 g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19111587]No cytotoxicity information found Not found 19111587 Peptides. 2009 Apr;30(4):633-637. "Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL." Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water. DRAMP00930 TESYFVFSVGM 11 Antimicrobial peptide 2 (Cn-AMP2; Plant defensin) P86706 Not found Not found Cocos nucifera (Coconut palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level). Subunit structure: Monomer." "[Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=150 g/ml), Staphylococcus aureus (MIC=170 g/ml);##Gram-negative bacteria: Escherichia coli (MIC=170 g/ml), Pseudomonas aeruginosa (MIC=169 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19111587]No cytotoxicity information found Not found 19111587 Peptides. 2009 Apr;30(4):633-637. "Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL." Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water. DRAMP00929 SVAGRAQGM 9 Antimicrobial peptide 1 (Cn-AMP1; Plant defensin) P86705 Not found Not found Cocos nucifera (Coconut palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Helix Not found 2N0V resolved by NMR. "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. Tissue specificity: Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level). Subunit structure: Monomer." "[Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=76 g/ml), Staphylococcus aureus (MIC=80 g/ml);##Gram-negative bacteria: Escherichia coli (MIC=82 g/ml), Pseudomonas aeruginosa (MIC=79 g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19111587]No cytotoxicity information found Not found 19111587 Peptides. 2009 Apr;30(4):633-637. "Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL." Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water. DRAMP03542 HKTDSFVGLM 10 "Neurokinin A (NKA; chicken, animals)" P19851 Belongs to the tachykinin family. Not found Gallus gallus (Chicken) "Antimicrobial, Antibacterial, Neuropeptide, Anti-Gram+, Anti-Gram-" Protein level Not found Not found 1N6T resolved by NMR. "Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Antibacterial activity is very low. PTM: Methionine amide at position 10." "[Ref.18603306] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>500 g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>500 g/ml) ;## Gram-positive bacteria: Streptococcus mutans NCTC 10449 (MIC> 500 g/ml), Lactobacillus acidophilus NCTC 1723 (MIC>500 g/ml), Enterococcus faecalis NCTC 12697 (MIC>500 g/ml), Staphylococcus aureus ATCC 25923 (MIC>500 g/ml);## Yeast: Candida albicans NCTC 3179 (MIC>500 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.18603306]No cytotoxicity information found Not found 18603306 J Neuroimmunol. 2008 Aug 30;200(1-2):11-16. "El Karim IA, Linden GJ, Orr DF, Lundy FT." "Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites." DRAMP03310 FLPLILRKIVTAL 13 "Crabrolin (Insects, animals)" P01518 Not found Not found Vespa crabro (European hornet) "Antimicrobial, Antibacterial, Anti Mammalian cells" Protein level Helix Not found None Function: Mast cell degranulating peptide. Induces the chemotaxis of neutrophils. Has antimicrobial and hemolytic activity. No MICs found in DRAMP database [Ref.6206053] Hemolysis is 20% of total at 10?g/ml against guinea pig red blood cell. Linear Free Amidation Free L [Ref.9273892]No cytotoxicity information found##[Ref.6206053]No cytotoxicity information found Not found 9273892##6206053 J Pept Res. 1997 Aug;50(2):88-93.##J Biol Chem. 1984 Aug 25;259(16):10106-10111. "Krishnakumari V, Nagaraj R.##Argiolas A, Pisano JJ." "Antimicrobial and hemolytic activities of crabrolin, a 13-residue peptide from the venom of the European hornet, Vespa crabro, and its analogs.##Isolation and characterization of two new peptides, mastoparan C and crabrolin, from the venom of the European hornet, Vespa crabro." DRAMP02344 KVHGSLARAGK 11 "40S ribosomal protein S30 (Fish, chordates, animals)" P83328 Belongs to the eukaryotic ribosomal protein eS30 family. fau Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and low activity against Gram-negative bacteria. "[Ref.12147245] Gram-negetive bacteria: Escherichia coli (EC50>0.3 M, MBC>0.3 M), Listonella anguillarum (EC50>0.3 M, MBC>0.3 M) ;##Gram-positive bacteria: Bacillus subtilis (EC50=0.15C0.3 M, MBC>0.3 M), Planococcus citreus (EC50=0.02C0.04 M, MBC=0.08 M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.12147245]No cytotoxicity information found Not found 12147245 Biochem Biophys Res Commun. 2002 Aug 9;296(1):167-171. "Fernandes JM, Smith VJ." A novel antimicrobial function for a ribosomal peptide from rainbow trout skin. DRAMP02993 YVPLPNVPQPGRRPFPTFPGQGPFNPKIKWPQGY 34 "Abaecin (Pro-rich; insects, arthropods, invertebrates, animals)" P15450? Not found Not found Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Rich The prolines are in repeated motifs. None Function: This peptide has bactericidal activity. "[Ref.2298215] Gram-negative bacteria: Agrobacterium tumefaciens Gembloux A (MIC=25-50 ?g/ml), Erwinia salicis NCPPB 2530 (MIC=25-50 ?g/ml), Escherichia coli NCTC 9001 (MIC=25-50 ?g/ml), Escherichia coli K514 (MIC=10-25 ?g/ml), Pseudomonas syringae pv.tomato NCPPB 1105 (MIC=25-50 ?g/ml), Xanthomonas campestris pv. vesicatoria LMG 905 (MIC=5-10 ?g/ml);##Gram-positive bacteria: Bacillus megateriurn QMB 1551 (MIC=10-25 ?g/ml), Micrococcus lysodeikticus LMG 4050 (MIC=10-25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.2298215]No cytotoxicity information found##[Ref.7961803]No cytotoxicity information found Not found 2298215##7961803 Eur J Biochem. 1990 Jan 26;187(2):381-386.##J Biol Chem. 1994 Nov 18;269(46):28569-28575. "Casteels P, Ampe C, Riviere L, Van Damme J, Elicone C, Fleming M, Jacobs F, Tempst P.##Casteels-Josson K, Zhang W, Capaci T, Casteels P, Tempst P." "Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera).##Acute Transcriptional Response of the Honeybee Peptide-Antibiotics Gene Repertoire and Required Post-translational Conversion of the Precursor Structures." DRAMP02997 GNNRPVYIPQPRPPHPRL 18 "Apidaecin-1B (Apidaecin IB; Insects, animals)" "P35581, Q06602, Q06601, Q8WSY8" Belongs to the apidaecin family Not found Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found 4E81 resolved by X-ray. Function: Apidaecins have bactericidal activity; predominantly against Gram-negative bacteria. They seem to interfere with cell propagation. "[Ref.2676519] Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 g/ml), Erwinia salicis (MIC=0.02 g/ml), Escherichia coli (MIC=0.1 g/ml), Pseudomonas syringae (MIC=0.1 g/ml), Rhizobium meliloti (MIC=0.02 g/ml), Salmonella Newport (MIC=0.2 g/ml), Salmonella typhimurium (MIC=0.1 g/ml), Shigella flexneri (MIC=0.1 g/ml);##Gram-positive bacteria: Corynebacterium insidiosum (MIC=50 g/ml), Bacillus megaterium (MIC=100 g/ml).##[Ref.2298215] Gram-negative bacteria: Agrobacterium tumefaciens Gembloux A (MIC1 ?g/ml), Erwinia salicis NCPPB 2530 (MIC1 ?g/ml), Escherichia coli NCTC 9001 (MIC1 ?g/ml), Escherichia coli K514 (MIC=25-50 ?g/ml), Pseudomonas syringae pv.tomato NCPPB 1105 (MIC1 ?g/ml), Xanthomonas campestris pv. vesicatoria LMG 905 (MIC100 ?g/ml);##Gram-positive bacteria: Bacillus megateriurn QMB 1551 (MIC=25-50 ?g/ml), Bacillus alvei LMG 6922 (MIC=50-100 ?g/ml),Micrococcus lysodeikticus LMG 4050 (MIC=25-50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.2298215]No cytotoxicity information found##[Ref.2676519]No cytotoxicity information found Not found 2676519##2298215 EMBO J. 1989 Aug;8(8):2387-2391.##Eur J Biochem. 1990 Jan 26;187(2):381-386. "Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P.##Casteels P, Ampe C, Riviere L, Van Damme J, Elicone C, Fleming M, Jacobs F, Tempst P." "Apidaecins: antibacterial peptides from honeybees.##Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera)." DRAMP18322 ITPATPFTPAIITEITAAVIA 21 Hominicin (Bacteriocin) No entry found Not found Not found Staphylococcus hominis MBBL 2-9 "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found "NMR played a critical role in establishing the peptide primary structure. While the N-terminal residue is an N,N-dimethyl Ile (DmIle), the C-terminus is a N2, N2-dimethyl-1,2-propanediamine (Dmp). In addition, threonines are dehydrated into Dhb. In this sense, this peptide may be classified as a class I variant bacteriocin." None "Function: Hominicin exhibited heat stability up to 121 degrees C for 15min and activity under both acidic and basic conditions (from pH 2.0 to 10.0). Hominicin exhibited distinct structural and attractive biochemical characteristics with a high bactericidal activity against MRSA and VISA, heat-tolerance and pH stability." "[Ref.20654578] Gram-positive bacteria: Staphylococcus aureus (MIC=0.06 ?g/ml), MRSA (MIC=0.96 ?g/ml), VISA (MIC=3.82 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free "1-DmIle(N,N-dimethyl Ile)-I; 2,5,8,15-DHB(dehydrated threonine)-T;21-Dmp(N2, N2-dimethyl-1,2-propanediamine)-A" L [Ref.20654578]No cytotoxicity information found Not found 20654578 Biochem Biophys Res Commun. 2010 Aug 20;399(2):133-138. "Kim PI, Sohng JK, Sung C, Joo HS, Kim EM, Yamaguchi T, Park D, Kim BG. " "Characterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2-9. " DRAMP02840 FKCRRWQWRMKKLGAPSITCVRRAF 25 "Lactoferricin B (Lfcin B; mammals, animals)" "P24627, E6YCQ7, B3VTM3, B9VPZ5, C7FE01, Q6LBN7, Q19KS1" Belongs to the transferrin family LTF Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Beta strand (4 strands; 8 residues) "Residues 7-9 form beta1 and residues 17-19 form beta2 (in membrane). This contrasts with X-ray structure where residues 1-13 is helical. Thus, this peptide appears to be able to adopt a different conformation depending on environmental conditions. disulfide bond is not required for the antimicrobial potency." 1LFC resolved by NMR. "Function: Lactoferricin B function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. Activity regulation: Inhibited by PMSF and Pefabloc. PTM: Contains one disulfide bond 3-20" "[Ref.8980754] Gram-negative bacteria: Escherichia coli L361 (MIC=4 ?M or 12.5 ?g/ml), Salmonella Salford (MIC=4 ?M or 12.5 ?g/ml), Escherichia coli O:9 (MIC=6 ?M or 18.8 ?g/ml), Pseudomonas ?uorescens (MIC=10 ?M or 31.3 ?g/ml) ;##Gram-positive bacteria: Listeria monocytogenes (MIC=2 ?M or 6.3 ?g/ml), Staphylococcus aureus (MIC=6 ?M or 18.8 ?g/ml), Bacillus cereus (MIC=6 ?M or 18.8 ?g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys3 and Cys20. L No cytotoxicity information found Not found 8980754##9521752##1490908 "Antimicrob Agents Chemother. 1997 Jan;41(1):54-59. ##Biochemistry. 1998 Mar 24;37(12):4288-4298.## J Appl Bacteriol. 1992 Dec;73(6):472-9." "Hoek KS, Milne JM, Grieve PA, Dionysius DA, Smith R. ##Hwang PM, Zhou N, Shan X, Arrowsmith CH, Vogel HJ. ##Bellamy W, Takase M, Wakabayashi H, Kawase K, Tomita M.1992" "Antibacterial activity in bovine lactoferrin-derived peptides. ##Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. ## Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. " DRAMP02244 GLFLDTLKGAAKDVAGKLLEGLKCKIAGCKP 31 "Ranatuerin-2Ca (Ranatuerin 2Ca; Frogs, amphibians, animals)" P82878 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide has defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, male-specific defense response to bacterium, antibacterial humoral response, antibacterial humoral response, induced systemic resistance, antifungal innate immune response, antifungal humoral response, defense response to fungus (incompatible interaction) in GO analysis. Tissue specificity: Expressed by the skin glands. PTM: Disulfide bond at position 24 and 29." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys24 and Cys29. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP01821 FLPFLASLLTKVL 13 "Temporin-1Cc (Temporin 1Cc; Frogs, amphibians, animals)" P82882 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial activity against the Gram-positive bacterium Staphylococcus aureus. Tissue specificity: Expressed by the skin glands. " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10822101]No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP01819 FLPFLAKILTGVL 13 "Temporin-1Ca (Temporin 1Ca; Frogs, amphibians, animals)" P82880 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial activity against the Gram-positive bacterium Staphylococcus aureus. Tissue specificity: Expressed by the skin glands. PTM: Leucine amide at position 13." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10822101]No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP01357 FLGGLMKAFPAIICAVTKKC 20 "Ranalexin-1Cb (Ranatuerin 1Cb; Frogs, amphibians, animals)" P82877 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide has defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, male-specific defense response to bacterium, antibacterial humoral response, antibacterial humoral response, induced systemic resistance, antifungal innate immune response, antifungal humoral response, defense response to fungus (incompatible interaction) in GO analysis. Tissue specificity: Expressed by the skin glands." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP02246 SMLSVLKNLGKVGLGLVACKINKQC 25 "Ranatuerin-1C (Ranatuerin 1C; Frogs, amphibians, animals)" P82875 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10822101] Gram-positive bacterium: Staphylococcus aureus (MIC=55 M);##Gram-negative bacterium: Escherichia coli (MIC=1.5 M).##Yeast: Candida albicans (MIC=58 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys19 and Cys25) Disulfide bond between Cys19 and Cys25. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP01394 GLLRASSVWGRKYYVDLAGCAKA 23 "Odorranain-W2 (Frogs, amphibians, animals)" A7YL71 Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Shows antibacterial and antifungal activities. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?g/ml), Bacillus dysenteriae (MIC=30 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=20 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17698252]No cytotoxicity information found Not found 17698252 Peptides. 2007 Aug;28(8):1527-1531. "Chen L, Li Y, Li J, Xu X, Lai R, Zou Q." An antimicrobial peptide with antimicrobial activity against Helicobacter pylori. DRAMP01395 VVKCSYRLGSPDSQCN 16 "Odorranain-A-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=35.2 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=17.6 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Free Disulfide bond between Cys4 and Cys15. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01396 GFMDTAKNVAKNMAGNLLDNLKCKITKAC 29 "Odorranain-F-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=2.5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=2.5 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01397 GFMDTAKNVAKNMAVTLLDNLKCKITKAC 29 "Odorranain-F-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.5 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.8 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01398 GFMDTAKNVAKNEAGNLLDNLKCKITKAC 29 "Odorranain-F-OA3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=6.3 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01399 GFMATAKNVAKNMDVTLLDNLKCKITKAC 29 "Odorranain-F-OA4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=4.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP18395 FFGHLFRGIINVGKHIHGLLSG 22 "moroPC-NH2 (moronecidin-like peptide; fish, animals)" No entry found Not found Not found Parachaenichthys charcoti "Antimicrobial, Antibacterial, Antifungal" Not found Not found None Comment: No comments found on DRAMP database "Active against Gram- E. cloacae ATCC 13047 (MIC 25 uM), S. sonnei (ATCC 29930) (MIC 5 uM), Psychrobacter sp. (PAMC 25501) (MIC 2.5 uM), E. coli DH5alpha (MIC 5 uM), Gram+ E. faecalis (ATCC 29212) (MIC 25 uM), S. pyogenes (ATCC 19615) (MIC 2.5 uM), S. aureus (ATCC 33591), L. monocytogenes (ATCC 15313) (MIC 5 uM), and yeast C. tropicalis (ATCC 20115) (MIC 5 uM). " No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.28122029]No cytotoxicity information found Not found 28122029 PLoS One. 2017 Jan 25;12(1):e0170821. "Shin SC, Ahn IH, Ahn DH, Lee YM, Lee J, Lee JH, Kim HW, Park H" Characterization of Two Antimicrobial Peptides from Antarctic Fishes (Notothenia coriiceps and Parachaenichthys charcoti) DRAMP01401 GFMNTAKNVAKNVAVTLLDNLKCKITGGC 29 "Odorranain-F-OW1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=2 ?M), Pseudomonas aeruginosa (MIC=4 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01402 GLFTLIKGAYKLDAPTVACN 20 "Odorranain-J-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=20.1 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01403 GLFTLIKGAYKNDAPTVACN 20 "Odorranain-J-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=20.1 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01409 GILSGILGVGKKLVCGLSGLC 21 "Nigrocin-OR1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=4 ?M), Pseudomonas aeruginosa (MIC=7 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M).##Yeast: Candida albicans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01410 GILSGILGVGKMLVCGLSGLC 21 "Nigrocin-OR2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Bacillus pyocyaneus CMCCB 10104 (MIC=5 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01411 GILSGLLGVGKMLVCGLSGLC 21 "Nigrocin-OR3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Bacillus pyocyaneus CMCCB 10104 (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01412 GLLGSLFGAGKKVACALSGLC 21 "Nigrocin-2HSa (Frogs, amphibians, animals)" P0C8U0 Not found Not found Odorrana hosii (Hose's rock frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 15-21." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=56 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=28 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01413 GLLGSIFGAGKKIACALSGLC 21 "Nigrocin-2HSb (Frogs, amphibians, animals)" P0C8U1 Not found Not found Odorrana hosii (Hose's rock frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 15-21." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=28 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=14 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01414 GIFSTVFKAGKGIVCGLTGLC 21 "Nigrocin-2ISa (Frogs, amphibians, animals)" F1T156 Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L [Ref.21193000]No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01415 GILGTVFKAGKGIVCGLTGLC 21 "Nigrocin-2ISb (Frogs, amphibians, animals)" F1T157 Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01416 GILSTVFKAGKGIVCGLSGLC 21 "Nigrocin-2ISc (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 ?M).##Yeast: Candida albicans (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 21867685 Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-677. "Iwakoshi-Ukena E, Soga M, Okada G, Fujii T, Sumida M, Ukena K." Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning. DRAMP01417 GLLSGILGAGKHIVCGLSGLC 21 "Nigrocin-2GRa (Frogs, amphibians, animals)" No entry found Not found Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial against Gram-negative bacterium E. coli. Also has a weak hemolytic activity against human erythrocytes. [Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=25 ?M). [Ref:16621155] LC50=295 M against human erythrocytes Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami." DRAMP01418 GLFGKILGVGKKVLCGLSGMC 21 "Nigrocin-2GRb (Frogs, amphibians, animals)" No entry found Not found Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against the Gram-negative bacterium E. coli and the Gram-positive bacterium S. aureus. Also has a weak hemolytic activity against human erythrocytes. [Ref.16621155]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Yeast: Candida albicans (MIC=50 ?M). [Ref:16621155] LC50=40 M against human erythrocytes Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami." DRAMP01419 GLLSGILGAGKNIVCGLSGLC 21 "Nigrocin-2GRc (Frogs, amphibians, animals)" No entry found Not found Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial against Gram-negative bacterium E. coli. Also has a weak hemolytic activity against human erythrocytes. [Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=50 ?M). [Ref:16621155] LC50>500 M against human erythrocytes Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami." DRAMP01420 GLLSGILGAGKHIICGLSGLC 21 "Nigrocin-OG4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC>100 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?g/ml), Bacillus subtilis (MIC>100 ?g/ml).##Yeast: Candida albicans (MIC=1.10 ?g/ml)." "[Ref.17272268] RCH=65.5 7.7% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01421 GLLSGILGAGKQKVCGLSGLC 21 "Nigrocin-OG5 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=9.37 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=18.75 ?g/ml), Bacillus subtilis (MIC=37.50 ?g/ml).##Yeast: Candida albicans (MIC=4.68 ?g/ml)." "[Ref.17272268] RCH=87.2 2.6% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01422 GLLSGVLGVGKKVLCGLSGLC 21 "Nigrosin-OG21 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=4.68 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml).##Yeast: Candida albicans (MIC=4.68 ?g/ml)." "[Ref.17272268] RCH=100% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01423 GLLSGILGAGKHIVCGLSGLR 21 "Nigrosin-OG13 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=4.68 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml).##Yeast: Candida albicans (MIC=1.10 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17272268]No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01426 GLLSGVLGVGKKIVCGLSGLC 21 "Nigrocin-1-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=5.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01427 GIFGKILGVGKKTLCELSGMC 21 "Nigrocin-1-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.3 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01428 GIFLKVLGVGKKVLCGVSGLC 21 "Nigrocin-1-OA3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=10.8 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01429 GLISGILGVGKKLVCGLSGLC 21 "Nigrocin-1-OR1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=11.5 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01430 GLISGILGVGKMLVCGLSGLC 21 "Nigrocin-1-OR2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=8.6 ?g/ml)" [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01431 GLISGLLGVGKMLVCGLSGLC 21 "Nigrocin-1-OR3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=10.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01432 GILGNIVGMGKKIVCGLSGLC 21 "Nigrocin-1-OW2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.2 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01433 GILGNIVGMGKKVVCGLSGLC 21 "Nigrocin-1-OW3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=6.7 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01434 GILSGVLGMGKKIVCGLRGLC 21 "Nigrocin-1-OW4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=14.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=7.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01435 GILGNIVGMGKQVVCGLSGLC 21 "Nigrocin-1-OW5 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=5.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01436 GILSGVLGMGKKIVCGLSGLC 21 "Nigrocin-1-OW1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=4.4 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP18394 RLNTTFRPLNFKMLRFWGQNRNIMKHRGQKVHFSLILSDCKTNKDCPKLRRANVRCRKSYCVPI 64 NCR335 (nodule-specific cysteine-rich peptides; plants) No entry found Not found Not found Medicago truncatula "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against S. enterica (MIC 16 uM) and L. monocytogenes (MIC 32 uM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bond between Cys40 and Cys61,Cys46 and Cys56." L [Ref.28167938]No cytotoxicity information found Not found 28167938 Front Microbiol. 2017 Jan 23;8:51. "Farkas A, Mar" Comparative Analysis of the Bacterial Membrane Disruption Effect of Two Natural Plant Antimicrobial Peptides. DRAMP01438 GIFGKILGAGKKVLCGLSGLC 21 "Nigrocin-2JDa (Frogs, amphibians, animals)" B3A0M6 Not found Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity against rabbit erythrocytes. PTM: contains one disulfide bond 15-21. " "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Staphylococcus aureus CIB 85462 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=16 ?M), Escherichia coli CIB 84492 (MIC=16 ?M);##Yeast: Candida albicans (MIC=63 ?M)." [Ref:22917879] It has 80.3 5.5% hemolytic activity at 128 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP01439 GIFGKILGVGKKVLCGLSGMC 21 "Nigrocin-2JDb (Odorranain-H2; Frogs, amphibians, animals)" B3A0M7 Not found Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity against rabbit erythrocytes. PTM: contains one disulfide bond 15-21. " "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15 ?M), Staphylococcus aureus CIB 85462 (MIC=15 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=8 ?M), Escherichia coli CIB 84492 (MIC=8 ?M);##Yeast: Candida albicans (MIC=31 ?M)." [Ref:22917879] It has 88.4 4.2% hemolytic activity at 128 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP01440 GILSGILGMGKKLVCGLSGLC 21 "Nigrocin-2LVb (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana livida (Chinese Odorrana frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 20158520 FEBS J. 2010 Mar;277(6):1519-1531. "Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C." Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis. DRAMP01441 SILSGNFGVGKKIVCGLSGLC 21 "Nigrocin-2VB (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana livida (Chinese Odorrana frogs) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 20158520 FEBS J. 2010 Mar;277(6):1519-1531. "Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C." Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis. DRAMP01442 GILSGILGAGKSLVCGLSGLC 21 "Nigrocin-2SCa (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana schmackeri (Chinese Odorrana frogs) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 20158520 FEBS J. 2010 Mar;277(6):1519-1531. "Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C." Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis. DRAMP01443 GILSNVLGMGKKIVCGLSGLC 21 "Nigrocin-2SCc (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana schmackeri (Chinese Odorrana frogs) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=70 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 20158520 FEBS J. 2010 Mar;277(6):1519-1531. "Wang L, Evaristo G, Zhou M, Pinkse M, Wang M, Xu Y, Jiang X, Chen T, Rao P, Verhaert P, Shaw C." Nigrocin-2 peptides from Chinese Odorrana frogs--integration of UPLC/MS/MS with molecular cloning in amphibian skin peptidome analysis. DRAMP01447 GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC 37 "Esculentin-2CHa (Frogs, amphibians, animals)" No entry found Not found Not found Lithobates chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: E. coli (MIC=5 ?M), K. pneumoniae (MIC=5 ?M), P. aeruginosa (MIC=5 ?M);##Gram-positive bacterium: S. aureus (MIC=5 ?M).##Yeast: C. albicans (MIC=10 ?M)." [Ref.21262304] LC50=150 ?M against human erythrocytes Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 21262304 Peptides. 2011 Apr;32(4):664-669. "Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01452 RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC 47 "Esculentin-1LTa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=0.6 ?M), Bacillus licheniformis X39 (MIC=10 ?M), Staphylococcus carnosus KHS (MIC=1.3 ?M), Rhodococcus rhodochrous X15 (MIC=0.3 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?M), Serratia rubidaea X01 (MIC=10 ?M), Psychrobacter faecalis X29 (MIC=0.6 ?M).##Yeast: Candida albicans ATCC2002 (MIC=80 ?M)." [Ref.22426384] LD50>480 M against human erythrocytes Cyclic Free Cyclization (Cys41 and Cys47) Disulfide bond between Cys41 and Cys47. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01453 GIFSLFKAGAKFFGKHLLKQAGKAGAEHLACKATNQC 37 "Esculentin-2LTa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.6 ?M), Bacillus licheniformis X39 (MIC=3.2 ?M), Staphylococcus carnosus KHS (MIC=3.2 ?M), Rhodococcus rhodochrous X15 (MIC=0.8 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=1.6 ?M). " [Ref.22426384] LD50>600 M against human erythrocytes Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01454 GLFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC 37 "Esculentin-2JDa (Frogs, amphibians, animals)" B3A0M8 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against E. coli and S. aureus strains (Probable). Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 31-37." "Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=34 ?g/ml), Extended-spectrum ??-lactamases E. coli (ESBL) (MIC=34 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (ATCC 25923) (MIC=8 ?g/ml), Methicillin-resistant S. aureus (MRSA) (MIC=8 ?g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: de novo sequencing and analysis of tandem mass spectrometry data." DRAMP01456 GLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC 37 "Esculentin-2PLa (Frogs, amphibians, animals)" "A7WNV5, D3UA57" Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against the Gram-negative bacterium E. coli, the Gram-positive bacterium: S. aureus and the yeast C. albicans. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 31-37." Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=10 ?M).##Yeast: Candida albicans (MIC=49 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01457 GIFSKFAGKGIKDLIIKGVKGIAKEAGMDVIRTGIDIAGCKIKGEC 46 "Esculentin-1V (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Chinese frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=4.9 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 16427248 Genomics. 2006 May;87(5):638-644. "Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C." Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs. DRAMP01458 GIFTLFKGAAKLLGKTLAKEAGKTGLELMACKVTNQC 37 "Esculentin-2V (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Chinese frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=4.4 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 16427248 Genomics. 2006 May;87(5):638-644. "Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C." Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs. DRAMP01461 GLFSKFAGKGIKNMIIKGIKGIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1S (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana schmackeri (piebald odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.7 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 16427248 Genomics. 2006 May;87(5):638-644. "Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C." Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs. DRAMP01462 GLFTLIKGAVKMIGKTVAKEAGKTGLELMACKVTNQC 37 "Esculentin-2S (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana schmackeri (piebald odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=2.6 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.1 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 16427248 Genomics. 2006 May;87(5):638-644. "Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C." Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs. DRAMP01469 GIFALIKTAAKFVGKNLLKQAGKAGLEHLACKANNQC 37 "Esculentin-2-Ala (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Esculentin-2-Ala exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus dysenteriae (MIC=7.5 ?g/mL), Bacillus cereus (MIC=7.5 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=12.5 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Acinetobacter calcoaceticus (MIC=25 ?g/mL), Psecdomonas aeruginosa (MIC=50 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)" [Ref:19843479] It has 22% hemolytic activity at 100 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloen." DRAMP01470 GIFSLIKTAAKFVGKNLLKQAGKAGVEHLACKANNQC 37 "Esculentin-2-ALb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Esculentin-2-Alb exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=7.5 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=12.5 ?g/mL), Bacillus dysenteriae (MIC=7.5 ?g/mL), Acinetobacter calcoaceticus (MIC=12.5 ?g/mL), Psecdomonas aeruginosa (MIC=50 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)." [Ref:19843479] It has 17% hemolytic activity at 100 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloen." DRAMP01471 GLFPKINKKKAKTGVFNIIKTVGKEAGMDLIRTGIDTIGCKIKGEC 46 "Esculentin-1PLa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North American pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01472 GIFTKINKKKAKTGVFNIIKTIGKEAGMDVIRAGIDTISCKIKGEC 46 "Esculentin-1PLb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North American pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP18393 AVKPKTAKPKTAKPKTA 17 VK6 (histone derived; reptiles; animals) No entry found Not found Not found "blood plasma, Komodo dragon, Varanus komodoensis" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against P. eruginosa ATCC9027 (EC50 3.6 uM) and S. aureus ATCC 25923 (EC50 3.3 uM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28164707]No cytotoxicity information found Not found 28164707 J Proteome Res. 2017 Apr 7;16(4):1470-1482. "Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML" Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry DRAMP01474 GIFSKINKKKAKTGLFNIIKTVGKEAGMDVIRAGIDTISCKIKGEC 46 "Esculentin-1ARa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana areolata (crawfish frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Esculentin-1ARa has antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Also exhibits hemolytic activity against human erythrocytes (HC50=180 ?M). [Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=13 ?M). [Ref:12429503] HC50=180 ?M against human erythrocytes Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 12429503 Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. "Ali MF, Lips KR, Knoop FC, Fritzsch B, Miller C, Conlon JM." "Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata." DRAMP01475 GLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC 46 "Esculentin-1ARb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana areolata (crawfish frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Esculentin-1ARb has antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Also exhibits hemolytic activity against human erythrocytes (HC50=120 ?M). [Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M). [Ref:12429503] HC50=120 ?M against human erythrocytes Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 12429503 Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. "Ali MF, Lips KR, Knoop FC, Fritzsch B, Miller C, Conlon JM." "Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata." DRAMP01476 GIFSLIKGAAQLIGKTVAKEAGKTGLELMACKVTKQC 37 "Esculentin-2HSa (Frogs, amphibians, animals)" P0C8T9 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hosii (Hose's rock frog) (Rana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 31-37." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=32 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01477 GIFSKFGGKAIKNLFIKGAKNIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1HSa (Frogs, amphibians, animals)" P0C8T8 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana hosii (Hose's rock frog) (Odorrana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 40-46." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01479 GLFSKLNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC 46 "Esculentin-1CPa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates capito (North American New World frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. [Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Yeast: Candida albicans (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 19635516 Peptides. 2009 Oct;30(10):1775-1781. "Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). DRAMP01480 GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC 37 "Esculentin-2CPa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates capito (North American New World frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. [Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Yeast: Candida albicans (MIC=25 ?M) No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 19635516 Peptides. 2009 Oct;30(10):1775-1781. "Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). DRAMP01482 GIFSKFAGKGIKNLLVKGVKNIGKEVGMDVIRTGIDIAGCKIKGEC 46 "Esculentin-1ISa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Japanese Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Shows antibacterial activity. "Gram-negative bacterium: Escherichia coli (MC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=25 ?M), Bacillus subtilis (MIC=25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01483 RIFSKIGGKAIKNLILKGIKNIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1ISb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Japanese Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity. "Gram-negative bacterium: Escherichia coli (MC=3.1 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01484 GIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC 37 "Esculentin-2ISa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Japanese Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity. "Gram-negative bacterium: Escherichia coli (MC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=25 ?M), Bacillus subtilis (MIC=6.3 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01486 GLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1GRa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grahami (Odorrana andersonii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Shows antibacterial activity, also activity against fungus C. albicans." Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M).##Yeast: Candida albicans (MIC>50 ?M). [Ref.16621155] LC50=210 M against human erythrocytes. Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 16621155 Peptides 2006; 27: 2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami." DRAMP01490 GILSLVKGVAKLAGKGLAKEGGKFGLELIACKIAKQC 37 "Esculentin-2A (Frogs, amphibians, animals)" P40845 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (European Edible frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species. "[Ref.8163497]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=0.8 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.4 ?M), Pseudomonas aeruginosa ATCC15692 (MIC=3.5 ?M)." [Ref:8163497] Not found in the literature Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 8163497 J Biol Chem. 1994 Apr 22;269(16):11956-11961. "Simmaco M, Mignogna G, Barra D, Bossa F." Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. DRAMP01491 GIFSKLAGKKLKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC 46 "Esculentin-1B (Frogs, amphibians, animals)" P40844 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (European Edible frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli D21 (MIC=0.2 ?M), Pseudomonas aeruginosa ATCC15692 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.1 ?M), Staphylococcus aureus cowan I (MIC=0.4 ?M).##Fungi: Candida albicans (MIC=0.5 ?M), Saccharomyces cerevisiae (MIC=0.9 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.8163497]No cytotoxicity information found Not found 8163497 J Biol Chem. 1994 Apr 22;269(16):11956-11961. "Simmaco M, Mignogna G, Barra D, Bossa F." Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. DRAMP01493 GLFSKFVGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=1.2 ?g/mL), Staphylococcus aureus ATCC 25923 (MIC=1.2 ?g/mL).##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.4 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01494 GLFSKFSGKGIKNFLIKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1-OA2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 ?g/mL);##Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=2.5 ?g/mL), Staphylococcus aureus ATCC 25923 (MIC=1.3 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.3 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01495 GLFSKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.4 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.4 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.7 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01496 GLFTKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2.8 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.8 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=5.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01497 GLFSKFAGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.4 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1.7 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.4 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.7 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01499 GIFSKISGKAIKNLFIKGAKNVGKEVGMDVVRTGIDVVGCKIKGEC 46 "Esculentin-1-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.4 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01501 GIFSKISGKAIKNLFIKGAKNVGKRVGMDVVRTGMDVVGCKIKGEC 46 "Esculentin-1-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.5 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=11 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=11 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01502 GIFSKISGKAIKNLFIKGAENVGKHVGIDVVRTGIDVVGCKIKGEC 46 "Esculentin-1-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01503 GIFSKISGKAIKNLFIKGAKNVGKEVGIDVVRTGMDVVGCKIKGEC 46 "Esculentin-1-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=4.1 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.1 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01504 GIFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC 37 "Esculentin-2-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.5 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.3 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=4.3 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.5 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01505 GLFTLIKGAAKLIGKTTAKEAGKTGKLEMACKITNQC 37 "Esculentin-2-OA2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP18392 AKKPVAKKAAGGVKKPK 17 VK7 (histone derived; reptiles; animals) No entry found Not found Not found "blood plasma, Komodo dragon, Varanus komodoensis" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against P. eruginosa ATCC9027 (EC50 38.4 uM) and S. aureus ATCC 25923 (EC50 1.3 uM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28164707]No cytotoxicity information found Not found 28164707 J Proteome Res. 2017 Apr 7;16(4):1470-1482. "Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML" Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry DRAMP01507 GVFTLIKGATQLIGKTLGKELGKTGLELMACKITNQC 37 "Esculentin-2-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=10.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01508 GVFTLIKGATQLIGKTLGKEVGKTGLELMACKITKQC 37 "Esculentin-2-OR2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.1 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=16.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.1 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01509 GVFTLLKGATQLIGKTLGKELGKTGLELMACKITNQC 37 "Esculentin-2-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=7.9 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.9 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=15.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01510 GVFTLIKGATQLIGKTLGKELGKTGLELMACKITEQC 37 "Esculentin-2-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=3.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01511 GVFTLIKGATQLIGKTLGKELGKTGLEIMACKITKQC 37 "Esculentin-2-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=15.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15.8 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=7.9 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01513 GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC 46 "Esculentin-1 (Frogs, amphibians, animals)" P32414 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.2 ?M), Pseudomonas aeruginosaATCC15692 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.1 ?M), Staphylococcus aureus Cowan1 (MIC=0.4 ?M).##Fungi: Candida albicans (MIC=0.5 ?M), Saccharomyces cerevisiae (MIC=0.9 ?M)." [Ref. 8163497] LC>100M Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.8508915]No cytotoxicity information found Not found 8508915 FEBS Lett. 1993 Jun 14;324(2):159-161. "Simmaco M, Mignogna G, Barra D, Bossa F." Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. DRAMP01520 GLLNTFKDWAISIAKGAGKGVLTTLSCKLDKSC 33 "Rugosin-A (Frogs, amphibians, animals)" P80954 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Glandirana rugosa (Japanese wrinkled frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." "Gram-positive bacteria: Staphylococcus aureus 209P (MIC=6.25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=12.5 ?g/ml), Micrococcus luteus ATCC9341 (MIC=25 ?g/ml), Streptococcus pyogenes COOK (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli NIHJ (MIC=100 ?g/ml), Pseudomonas aeruginosa PAO-1 (MIC>100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L [Ref.7612013]No cytotoxicity information found Not found 7612013 Biochem Biophys Res Commun. 1995 Jul 6;212(1):249-254. "Suzuki S, Ohe Y, Kagegawa T, Tatemoto K." "Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa." DRAMP01521 SLFSLIKAGAKFLGKNLLKQGAQYAACKVSKEC 33 "Rugosin-B (Frogs, amphibians, animals)" P80955 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-negative and Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." "Gram-positive bacteria: Staphylococcus aureus 209P (MIC=6.25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=6.25 ?g/ml), Micrococcus luteus ATCC9341 (MIC=1.56 ?g/ml), Streptococcus pyogenes COOK (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli NIHJ (MIC=12.5 ?g/ml), Pseudomonas aeruginosa PAO-1 (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L [Ref.7612013]No cytotoxicity information found Not found 7612013 Biochem Biophys Res Commun. 1995 Jul 6;212(1):249-254. "Suzuki S, Ohe Y, Kagegawa T, Tatemoto K." "Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa." DRAMP01524 SIRDKIKTIAIDLAKSAGTGVLKTLICKLDKSC 33 "Rugosin-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has weak hemolytic activity gainst rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.69 ?g/ml), Bacillus subtilis (MIC=9.38 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=5.63 ?g/ml)" [Ref:19778602]Show weak hemolytic activity against rabbit red cells Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01525 SIRDKIKTIAIDLAKSAGMGILKTLICKLDKSC 33 "Rugosin-RN3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=16.51 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=15.00 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01526 SIRDKIKTIAIDLAKSAGTGVLKTLICKLNKSC 33 "Rugosin-RN5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=15.00 ?g/ml), Staphylococcus aureus ATCC43300 (MRSA) (MIC=12.50 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=18.75 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01533 CVISAGWNHKIRCKLTGNC 19 "Nigroain-B1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Bridge Not found None PTM: Contains one disulfide bridge. "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.69 ?g/ml), S. aureus ATCC43300 (MIC=50.00 ?g/ml);##Gram-negative bacteria: Pseudomonas aeruginosa PA01 (MIC=25.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25.00 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys13 and Cys19) Disulfide bridge between Cys13 and Cys19. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01539 FKTWKRPPFQTSCWGIIKE 19 "Nigroain-C2 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=27.50 ?g/ml), S. aureus ATCC43300 (MIC=55.00 ?g/ml), Bacillus subtilis (MIC=110.00 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=110.00 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=55.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=55.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=13.75 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01542 CVHWQTNTARTSCIGP 16 "Nigroain-D3 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None PTM: Contains one disulfide bridge. Gram-positive bacterium: Bacillus subtilis (MIC=55 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=110 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (Cys1 and Cys13) Free Disulfide bridge between Cys1 and Cys13. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01543 DCTRWIIGINGRICRD 16 "Nigroain-E1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells. [Ref.19778602]Gram-positive bacterium: Staphylococcus aureus ATCC25923 (MIC=18.75 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=75 ?g/ml). [Ref:19778602]7.621.6% hemolytic activity at 100 ?g/ml against rabbit red cells Cyclic Free Free Disulfide bridge between Cys2 and Cys14. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01546 SLWETIKNAGKGFIQNLDKIR 21 "Nigroain-K1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. Also has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=21.88 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=32.74 ?g/ml)." [Ref:19778602]22.49 4.8% hemolytic activity at 100 ?g/ml against rabbit red cells Linear Free Free Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01547 SLWETIKNAGKGFILNILDKIRCKVAGGCKT 31 "Nigroain-K2 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. Also has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=11.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=9.38 ?g/ml);##Gram-positive bacteria: Escherichia coli ML-35P (MIC=25.00 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=25.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25.00 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=15.00 ?g/ml)" [Ref:19778602]85.52 3.26% hemolytic activity at 50 ?g/ml against rabbit red cells Cyclic Free Free Disulfide bridge between Cys23 and Cys29. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01549 GLLSVLGSVAKHVLPHVVPVIAEHL 25 "Caerin-1.1 (Frogs, amphibians, animals)" "P62568, P62569, Q800R2, P56226" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria splendida (Magnificent tree frog) (Litoria gilleni) (Litoria caerulea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Alpha helix The peptide adopts two well-defined helices from Leu2 to Lys11 and from Val17 to His24 separated by a region of less-defined helicity and greater flexibility. None "Function: Antibacterial and antiviral peptides that adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Secreted by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility. Miscellaneous: Caerin 1.1 completely inhibits HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606). PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=1.5 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12.5 ?g/ml), Staphylococcus aureus (MIC=3-12 ?g/ml), Staphylococcus epidermis (MIC=12.5 ?g/ml), Streptococcus uberis (MIC=12.5 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml).##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=7.8 M);inhibition of HIV transfer by dendritic cells to T cells(IC50=12.6 M)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Cell membrane 16140737##9266696##12709067##15203252 J Virol. 2005 Sep;79(18):11598-606. ##Eur J Biochem. 1997 Jul 15;247(2):545-557.##Eur J Biochem. 2003 May;270(9):2068-2081.##Peptides. 2004 Jun;25(6):1035-1054. "VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Wong H, Bowie JH, Carver JA.##Vanhoye D, Bruston F, Nicolas P, Amiche M.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.##Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01550 GLLGAMFKVASKVLPHVVPAITEHF 25 "Caerin-1.11 (Frogs, amphibians, animals)" Q800R9 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None "Function: Antibacterial and antiviral peptides that adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity (By similarity). PTM: C-terminal amidation." "Gram-negative bacteria: Escherichia coli B (MIC=25 ?M), Enterobacter cloacae (MIC=50 ?M), Klebsiella pneumoniae (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus haemolyticus (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.12709067]No cytotoxicity information found##[Ref.22771617]No cytotoxicity information found Not found 12709067##22771617 Eur J Biochem. 2003 May;270(9):2068-2081.##Peptides. 2012 Sep;37(1):174-188. "Vanhoye D, Bruston F, Nicolas P, Amiche M.##Bowie JH, Separovic F, Tyler MJ." "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Host-defense peptides of Australian anurans. Part 2. Structure, activity, mechanism of action, and evolutionary significance." DRAMP01552 GLLSVLGSVAQHVLPHVVPVIAEHL 25 "Caerin-1.3 (Frogs, amphibians, animals)" P56228 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Australian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Staphylococcus aureus (MIC=6-12 ?g/ml), Staphylococcus epidermis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). (Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01553 GLLSSLSSVAKHVLPHVVPVIAEHL 25 "Caerin-1.4 (Frogs, amphibians, animals)" "P62544, P56229, P62545, P56229" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) (also Litoria gilleni) (Centralian tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=0.4 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=100 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=50 ?g/ml), Pasteurella multocida (MIC=25 ?g/ml). (Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01555 GLLSVLGSVVKHVIPHVVPVIAEHL 25 "Caerin-1.5 (Frogs, amphibians, animals)" P56230 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). ##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 12.5 ?M. Not found 26026377##15203252##PubMed ID is not available Peptides. 2015 Sep;71:296-303. ##Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01560 GLFGVLGSIAKHVLPHVVPVIAEKL 25 "Caerin-1.9 (Frogs, amphibians, animals)" P81252 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria chloris (Blue-thighed frog) (frog skin active peptide family) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin dorsal glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation. Miscellaneous: Caerin 1.9 completely inhibited HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606)." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=50 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=1.2 M);inhibition of HIV transfer by dendritic cells to T cells(IC50=1.6 M).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 20 ?M." Not found 26026377##16140737##15203252##9516047 Peptides. 2015 Sep;71:296-303. ##J Virol. 2005 Sep;79(18):11598-606. ##Peptides. 2004 Jun;25(6):1035-1054.##J Pept Res. 1998 Feb;51(2):121-126. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria." DRAMP01562 GLVSSIGRALGGLLADVVKSKGQPA 25 "Caerin-2.1 (Frogs, amphibians, animals)" "P56233, P86485" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria splendida (Magnificent tree frog) (Emerald spotted tree frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). (Ref.2) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.15203252]No cytotoxicity information found##[Ref.19642086]No cytotoxicity information found Not found 15203252##19642086 Peptides. 2004 Jun;25(6):1035-1054.##Rapid Commun Mass Spectrom. 2009 Sep;23(17):2628-2636. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Bilusich D, Jackway RJ, Musgrave IF, Tyler MJ, Bowie JH." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##The host-defence skin peptide profiles of Peron's Tree Frog Litoria peronii in winter and summer. Sequence determination by electrospray mass spectrometry and activities of the peptides." DRAMP01563 GLVSSIGRALGGLLADVVKSKEQPA 25 "Caerin-2.2 (Frogs, amphibians, animals)" "P62570, P62571, P56234" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gilleni (Centralian tree frog) (also Litoria caerulea) (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." Gram-positive bacterium: Micrococcus luteus (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01567 GLVSSIGKVLGGLLADVVKSKGQPA 25 "Caerin-2.6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Caerin subfamily) Not found the skin secretions) (hybrid between female Litoria splendida; also male Litoria caerulea "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity (By similarity). PTM: C-terminal amidation." Gram-positive bacterium: Leuconostoc lactis (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.16824041]No cytotoxicity information found Not found 16824041 FEBS J. 2006 Aug;273(15):3511-3519. "Pukala TL, Bertozzi T, Donnellan SC, Bowie JH, Surinya-Johnson KH, Liu Y, Jackway RJ, Doyle JR, Llewellyn LE, Tyler MJ." "Host-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea." DRAMP01568 GLVSSIGKALGGLLVDVVKSKGQPA 25 "Caerin-2.7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Caerin subfamily) Not found the skin secretions) (hybrid between female Litoria splendida; also male Litoria caerulea "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity (By similarity). PTM: C-terminal amidation." Gram-positive bacterium: Leuconostoc lactis (MIC=50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.16824041]No cytotoxicity information found Not found 16824041 FEBS J. 2006 Aug;273(15):3511-3519. "Pukala TL, Bertozzi T, Donnellan SC, Bowie JH, Surinya-Johnson KH, Liu Y, Jackway RJ, Doyle JR, Llewellyn LE, Tyler MJ." "Host-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea." DRAMP01570 GLWEKIKEKASELVSGIVEGVK 22 "Caerin-3.2 (Frogs, amphibians, animals)" P56239 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. PTM: C-terminal amidation." Gram-positive bacterium: Micrococcus luteus (MIC=3 ?g/ml). (Ref.2) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01573 GLWEKVKEKANELVSGIVEGVK 22 "Caerin-3.5 (Frogs, amphibians, animals)" P0C2A9 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gracilenta (Dainty green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms. Tissue specificity: Expressed by the skin dorsal glands." Gram-positive bacterium: Leuconostoc lactis (MIC=100 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16554081]No cytotoxicity information found Not found 16554081 Toxicon. 2006 May;47(6):664-675. "Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ." New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. DRAMP01574 GLWQKIKSAAGDLASGIVEGIKS 23 "Caerin-4.1 (Frogs, amphibians, animals)" P56242 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Alpha helix Not found None "PTM: adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." [Ref.15203252]Gram-positive bacterium: Micrococcus luteus (MIC=12 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01576 GLWQKIKNAAGDLASGIVEGIKS 23 "Caerin-4.3 (Frogs, amphibians, animals)" P56244 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. PTM: C-terminal amidation." Gram-positive bacterium: Micrococcus luteus (MIC=25 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=50 ?g/ml).(Ref.2) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01577 GLLSVLGSVAKHVLPHVVPVIAEKL 25 "Caerin-1.10 (Frogs, amphibians, animals)" "P86502, P82104" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria rothii (Roth's tree frog); also Litoria splendida (Magnificent tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide with wide spectrum of activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.10601876]Gram-positive bacteria: Leuconostoc lactis (MIC=6 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml), Staphylococcus epidermidis (MIC=100 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=100 ?g/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 22 ?M." Not found 26026377##16124032##10601876 Peptides. 2015 Sep;71:296-303. ##Rapid Commun Mass Spectrom. 2005;19(18):2716-2724.##Eur J Biochem. 2000 Jan;267(1):269-275. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Brinkworth CS, Bowie JH, Bilusich D, Tyler MJ.##Wabnitz PA, Bowie JH, Tyler MJ, Wallace JC, Smith BP." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##The rothein peptides from the skin secretion of Roth's tree frog Litoria rothii. Sequence determination using positive and negative ion electrospray mass spectrometry.##Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10." DRAMP18389 AKKPVAKKAAGGVKKPKK 18 VK12 (histone derived; animals) No entry found Not found Not found "blood plasma, Komodo dragon, Varanus komodoensis" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against P. eruginosa ATCC9027 (EC50 0.7 uM) and S. aureus ATCC 25923 (EC50 0.8 uM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28164707]No cytotoxicity information found Not found 28164707 J Proteome Res. 2017 Apr 7;16(4):1470-1482. "Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML" Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry DRAMP18390 AKAVKPKTAKPKTAKPKTAKA 21 VK11 (histone derived; reptiles; animals) No entry found Not found Not found "blood plasma, Komodo dragon, Varanus komodoensis" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against P. eruginosa ATCC9027 (EC50 2.8 uM) and S. aureus ATCC 25923 (EC50 4.7 uM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28164707]No cytotoxicity information found Not found 28164707 J Proteome Res. 2017 Apr 7;16(4):1470-1482. "Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML" Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry DRAMP18391 ARTKQTARKSTGGKAPRKQLAT 22 VK10 (histone derived; reptiles; animals) No entry found Not found Not found "blood plasma, Komodo dragon, Varanus komodoensis" "Antimicrobial, Antibacterial" Not found Not found "2PY0, 2NQB, 2IO5, 2FJ7, 1ZLA, 1KX3, 1KX4, 1KX5,1HIO" Comment: No comments found on DRAMP database Active against P. eruginosa ATCC9027 (EC50 1.3 uM) and S. aureus ATCC 25923 (EC50 2.5 uM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28164707]No cytotoxicity information found Not found 28164707 J Proteome Res. 2017 Apr 7;16(4):1470-1482. "Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML" Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry DRAMP01584 GLFSVLGSVAKHLLPHVAPIIAEKL 25 "Caerin-1.17 (Frogs, amphibians, animals)" P0C2A6 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gracilenta (Dainty green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Caerin-1.17 shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus Strain ATCC 25923 (MIC=50 ?g/ml), Staphylococcus aureus Strain ATCC 29213 (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml), Pasteurella multocida (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16554081]No cytotoxicity information found Not found 16554081 Toxicon. 2006 May;47(6):664-675. "Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ." New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. DRAMP01585 GLFSVLGSVAKHLLPHVVPVIAEKL 25 "Caerin-1.18 (Frogs, amphibians, animals)" P0C2A7 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gracilenta (Dainty green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=25 ?g/ml), Listeria innocua (MIC=12 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus ATCC 25923 (MIC=12 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=25 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacteria: Pasteurella multocida (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16554081]No cytotoxicity information found Not found 16554081 Toxicon. 2006 May;47(6):664-675. "Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ." New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. DRAMP01586 GLFKVLGSVAKHLLPHVAPIIAEKL 25 "Caerin-1.19 (Frogs, amphibians, animals)" P0C2A8 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gracilenta (Dainty green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Caerin-1.19 shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "[Ref.16554081]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=12 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Staphylococcus aureus Strain ATCC 25923 (MIC=12 ?g/ml), Staphylococcus aureus Strain ATCC 29213 (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacteria: Pasteurella multocida (MIC=50 ?g/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Not found 26026377##16554081 Peptides. 2015 Sep;71:296-303. ##Toxicon. 2006 May;47(6):664-675. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ." Inhibition of HIV infection by caerin 1 antimicrobial peptides.##New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. DRAMP01587 GLFDVIKKVASVIGGL 16 "Citropin-1.1 (Frogs, amphibians, animals)" "P81835, P81836, P81837" Not found Not found Litoria citropa (Australian blue mountains tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix Not found None "Function: Bacteriostatic action for Gram-positive bacteria. Tissue specificity: Expressed by the dorsal and submental skin glands. PTM: C-terminal amidation." "Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=6 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10504394]No cytotoxicity information found Not found 10504394 Eur J Biochem. 1999 Oct;265(2):627-637. "Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ." Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1. DRAMP01588 GLFAVIKKVASVIGGL 16 "Citropin-1.1 sm1 (Frogs, amphibians, animals)" No entry found Not found Not found Synthesized modify "Antimicrobial, Antibacterial, Anti-Gram+" Synthetic Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the dorsal and submental skin glands." "Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Escherichia coli (MIC=100 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10504394]No cytotoxicity information found Not found 10504394 Eur J Biochem. 1999 Oct;265(2):627-637. "Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ." Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1. DRAMP01589 GLFDVIAKVASVIGGL 16 "Citropin-1.1 sm2 (Frogs, amphibians, animals)" No entry found Not found Not found Synthesized modify "Antimicrobial, Antibacterial, Anti-Gram+" Synthetic Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the dorsal and submental skin glands." "Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=25 ?g/ml), Micrococcus luteus (MIC=100 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermidis (MIC=100 ?g/ml), Streptococcus uberis (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10504394]No cytotoxicity information found Not found 10504394 Eur J Biochem. 1999 Oct;265(2):627-637. "Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ." Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1. DRAMP01590 GLFDVIAKVASVIKKL 16 "Citropin 1.1 M14 (Frogs, amphibians, animals)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: E. coli (MIC=53 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.20564028]No cytotoxicity information found Not found 20564028 Biopolymers. 2011;96(2):147-157. "Chia CS, Gong Y, Bowie JH, Zuegg J, Cooper MA. " "Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin." DRAMP01591 GLFAVIKKVASVIKKL 16 "Citropin 1.1 M15 (Frogs, amphibians, animals)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: E. coli (MIC=53 ?M);##Gram-positive bacteria: S. aureus (MIC=3 ?M), B. subtilis (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.20564028]No cytotoxicity information found Not found 20564028 Biopolymers. 2011;96(2):147-157. "Chia CS, Gong Y, Bowie JH, Zuegg J, Cooper MA. " "Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin." DRAMP01594 GLFDIIKKVASVVGGL 16 "Citropin-1.2 (Frogs, amphibians, animals)" "P81840, P81841, P81842, P81843" Not found Not found Litoria citropa (Australian blue mountains tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the dorsal and submental skin glands." "Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermidis (MIC=25 ?g/ml), Streptococcus uberis (MIC=12 ?g/ml). (Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found##[Ref.10504394]No cytotoxicity information found Not found 10504394##15203252 Eur J Biochem. 1999 Oct;265(2):627-637.##Peptides. 2004 Jun;25(6):1035-1054. "Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01600 GLFDIIKKVASVIGGL 16 "Citropin-1.3 (Frogs, amphibians, animals)" P81846 Not found Not found Litoria citropa (Australian blue mountains tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the dorsal and submental skin glands." "Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Leuconostoc lactis (MIC=6 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermidis (MIC=25 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml). (Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found##[Ref.10504394]No cytotoxicity information found Not found 10504394##15203252 Eur J Biochem. 1999 Oct;265(2):627-637.##Peptides. 2004 Jun;25(6):1035-1054. "Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01601 GLIGSIGKALGGLLVDVLKPKL 22 "Citropin-2.1 (Frogs, amphibians, animals)" No entry found Not found Not found Litoria citropa (Australian blue mountains tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the dorsal and submental skin glands." Gram-positive bacterium: Leuconostoc lactis (MIC=50 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10504394]No cytotoxicity information found Not found 10504394 Eur J Biochem. 1999 Oct;265(2):627-637. "Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ." Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1. DRAMP01602 GLIGSIGKALGGLLVDVLKPKLQAAS 26 "Citropin-2.1.3 (Frogs, amphibians, animals)" "P81847, P81848, P81849, P81850" Not found Not found Litoria citropa (Australian blue mountains tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the dorsal and submental skin glands." Gram-positive bacterium: Leuconostoc lactis (MIC=100 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10504394]No cytotoxicity information found Not found 10504394 Eur J Biochem. 1999 Oct;265(2):627-637. "Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ." Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1. DRAMP01603 GLFDVIKKVASVIGLASP 18 "Citropin 1.1.3 (Frogs, amphibians, animals)" P81838 Not found Not found Litoria citropa (Australian blue mountains tree frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the dorsal and submental skin glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=50 ?g/ml), Streptococcus uberis (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10504394]No cytotoxicity information found Not found 10504394 Eur J Biochem. 1999 Oct;265(2):627-637. "Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ." Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1. DRAMP01606 GLFDIIKKIAESI 13 "Aurein-1.1 (Frogs, amphibians, animals)" P82386 Not found Not found Litoria raniformis (Southern bell frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Expressed by the skin dorsal glands. "Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Lactococcus lactis (MIC=25 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Streptococcus uberis (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191 Eur J Biochem. 2000 Sep;267(17):5330-5341. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ." The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. DRAMP01607 GLFDIIKKIAESF 13 "Aurein-1.2 (Frogs, amphibians, animals)" P82387 Not found Not found Litoria raniformis (Southern bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Alpha helix (1 helices; 10 residues) Not found 1VM5 resolved by NMR. Function: Probably acts by disturbing membrane functions with its amphipathic structure. Aurein 1.2 is HIV active (Wang G et al. 2010 Antimicrob. Agents Chemother. (54) 1343-1346). Aurein 1.2 is also the smallest amphibian peptide to show both antibiotic and Anti-cancer activity. The aurein antibiotics show more activity towards Gram-positive than Gram-negative pathogens. Expressed by the skin dorsal glands. "Gram-positive bacteria: Bacillus cereus (MIC=100 g/ml), Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=50 g/ml), Staphylococcus aureus (MIC=8 mol/L);##Gram-negative bacteria: Pasteurella multocida (MIC=100 g/ml), Escherichia coli (MIC=8 mol/L);##Fungi: Candida albicans (MIC=32 mol/L)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found##[Ref.15572363]No cytotoxicity information found Cell membrane 10951191##15572363##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##J Biol Chem. 2005 Feb 18;280(7):5803-5811.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Wang G, Li Y, Li X.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01612 GLFDIVKKVVGAFGSL 16 "Aurein-2.5 (Frogs, amphibians, animals)" "P69018, P69019, P82392" Not found Not found Litoria raniformis (Southern bell frog); also Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.10951191]Gram-positive bacteria: Bacillus cereus (MIC=50 g/ml), Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=50 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=100 g/ml), Staphylococcus aureus (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01613 GLFDIAKKVIGVIGSL 16 "Aurein-2.6 (Frogs, amphibians, animals)" P82393 Not found Not found Litoria raniformis (Southern bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Bacillus cereus (MIC=100 g/ml), Leuconostoc lactis (MIC=6 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=25 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Staphylococcus aureus (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01614 GLFDIVKKIAGHIAGSI 17 "Aurein-3.1 (Frogs, amphibians, animals)" "P69020, P69021, P82394" Not found Not found Litoria raniformis (Southern bell frog); also Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.10951191]Gram-positive bacteria: Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=100 g/ml), Streptococcus uberis (MIC=100 g/ml), Staphylococcus aureus (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01617 GLFDIVKKIAGHIASSI 17 "Aurein-3.2 (Frogs, amphibians, animals)" "P69022, P69023, P82395" Not found Not found Litoria aurea (green; also golden bell frog); also Litoria raniformis (blue-thighed treefrog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=6 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=50 g/ml), Staphylococcus aureus (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01618 GLFDIVKKIAGHIVSSI 17 "Aurein-3.3 (Frogs, amphibians, animals)" P82396 Not found Not found Litoria raniformis (blue-thighed treefrog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=12 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=25 g/ml), Staphylococcus aureus (MIC=100 g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=100 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01620 GLMSSIGKALGGLIVDVLKPKTPAS 25 "Aurein-5.2 (Frogs, amphibians, animals)" "P69030, P82402, P69031, P82402" Not found Not found Litoria raniformis (blue-thighed treefrog); also Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=100 g/ml), Streptococcus uberis (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01621 IIGPVLGMVGSALGGLLKKI 20 "Bombinin-H1 (Frogs, amphibians, animals)" "P82282, P82283" Belongs to the bombinin family Not found Bombina variegata (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation and D-amino acid." [Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=3.8 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=2.1 ?M). [Ref:8223491]Not determined hemolytic activity against human red blood cells. Linear Free Amidation Free L [Ref.8223491]No cytotoxicity information found Not found 8223491 EMBO J. 1993 Dec;12(12):4829-4832. "Mignogna G, Simmaco M, Kreil G, Barra D." Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata. DRAMP03722 IFGAIWNGIKSLF 13 Cytotoxic linear peptide IsCT2 Q8MTX2 Belongs to the scorpion NDBP 5 family Not found Opisthacanthus madagascariensis (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: IsCT2 showed broad activity spectra against microbes (Gram positive and negative bacteria as well as fungi). Has hemolytic activity. "[Ref.12054688] Gram-negetive bacteria: P.aeroginosa ATCC 15442 (MIC>150 M), P.aeroginosa ATCC 27853 (MIC=68.3 M), E.coli CCT 1371 (MIC=3.4 M), Escherichia coli ATCC 25922 (MIC=6.8 M), P. mirabilis (MIC>150 M);## Gram-positive bacteria: S.aureus ATCC 25293 (MIC=0.7 M), S.aureus ATCC 6538 (MIC=3.4 M), S.saprophyticus (MIC=0.7 M), B.thuringensis (MIC=17.1 M), B.subtilis CCT 2471 (MIC=6.8M).##[Ref.28657596] Gram-positive bacterium:Staphylococcus aureus (MIC=50g/mL), B. cereus (MIC=100g/mL);##Gram-negative bacterium: S. typhimurium (MIC=100g/mL), Escherichia coli (MIC=50g/mL)" "[Ref.12054688] Showed relatively weak hemolytic activity against sheep red blood cells.##[Ref.28657596] 18% hemolysis at 10 g/ml, 96% hemolysis at 50 g/ml against human red blood cells." Linear Free Amidation Free L [Ref.12054688]No cytotoxicity information found##[Ref.28657596]No cytotoxicity information found Not found 12054688##28657596 Biochem Biophys Res Commun. 2002 May 24;293(5):1514-1522.##Antibiotics (Basel). 2017 Jun 28;6(3). pii: E13. "Dai L, Corzo G, Naoki H, Andriantsiferana M, Nakajima T.##de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM." "Purification, structure-Function: analysis, and molecular characterization of novel linear peptides from scorpion Opisthacanthus madagascariensis.##Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides" DRAMP01626 IIGPVLGLVGSALGGLLKKI 20 "Bombinin-H5 (Frogs, amphibians, animals)" P82285 Belongs to the bombinin family Not found Bombina variegata (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix (1 helices; 16 residues) Not found "2AP7, 2AP8 resolved by NMR." "Function: Has antimicrobial activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation and D-amino acid." [Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=5.0 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.0 ?M). [Ref:8223491]Not found Linear Free Amidation Free Mixed (2D-aIle(alloisoleucine)) [Ref.8223491]No cytotoxicity information found Not found 8223491##PubMed ID is not available EMBO J. 1993 Dec;12(12):4829-4832##TO BE PUBLISHED "Mignogna G, Simmaco M, Kreil G, Barra D.##Zangger K, Jilek A, Khatai L." Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.##Solution structure and orientation of bombinin H2 and H4 in a membrane-mimetic environment. DRAMP01627 YPPKPESPGEDASPEEMNKYLTALRHYINLVTRQRY 36 "Skin peptide tyrosine-tyrosine (Skin-PYY; SPYY; Frogs, amphibians, animals)" P80952 Belongs to the NPY family Not found Phyllomedusa bicolor (Two-colored leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria, yeast and fungi. Tissue specificity: Skin. PTM: C-terminal amidation (By similarity)." "Gram-negative bacteria: Aeromonas caviae (MIC=40 ?g/ml), Escherichia coli (MIC=10 ?g/ml);##Gram-positive bacteria: Enterococcus faecalis (MIC=10 ?g/ml), Nocardia brasiliensis (MIC=20 ?g/ml).##Fungi: Cryptococcus neoformans (MIC=20 ?g/ml), Candida albicans (MIC=15 ?g/ml), Microsporum canis (MIC=10 ?g/ml), Tricophyton rubrum (MIC=15 ?g/ml), Arthroderma simii (MIC=10 ?g/ml), Aspergillus fumigatus (MIC=80 ?g/ml), Aspergillus niger (MIC>100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.8601432]<20% cytotoxic against murine macrophages at the concentration up to 100g/ml##[Ref.7937944]No cytotoxicity information found Cell membrane 7937944##8601432 Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10295-10299.##FEBS Lett. 1996 Feb 19;380(3):237-240. "Mor A, Chartrel N, Vaudry H, Nicolas P.##Vouldoukis I, Shai Y, Nicolas P, Mor A." "Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.##Broad spectrum antibiotic activity of the skin-PYY." DRAMP01628 GWMSKIASGIGTFLSGMQQ 19 "Phylloxin (Frogs, amphibians, animals)" "P81565, Q9PT74" Belongs to the frog skin active peptide family (Dermaseptin subfamily) PLX Phyllomedusa bicolor (Two-colored leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None "Function: Antimicrobial peptide against the Gram-positive bacteria and the Gram-negative-bacteria. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "Gram-negative bacteria: Acholeplasma laidlawii A-PG8 (MIC=12.5 ?M), Spiroplasma melliferum BC3 (MIC=50 ?M), Rhizobium meliloti 102F34 (MIC=12.5 ?M), Escherichia coli K12 (MIC=10 ?M);##Gram-positive bacteria: Bacillus megaterium KM (MIC=3.12 ?M), Corynebacterium glutamicum ATCC 27853 (MIC=1.56 ?M), Micrococcus luteus ATCC 27853 (MIC=3.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10632707]No cytotoxicity information found Not found 10632707 Eur J Biochem. 2000 Jan;267(2):370-378. "Pierre TN, Seon AA, Amiche M, Nicolas P." "Phylloxin, a novel peptide antibiotic of the dermaseptin family of antimicrobial/opioid peptide precursors." DRAMP01638 GLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS 32 "Dermaseptin-L1 (Frogs, amphibians, animals)" No entry found Not found Not found Hylomantis lemur (Lemur leaf frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=8 ?M).##Fungi: Batrachochytrium dendrobatidis (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17561225]Displayed cytotoxic against HepG2 cells(LC50=45M) Not found 17561225 Toxicon. 2007 Sep 15;50(4):498-506. "Conlon JM, Woodhams DC, Raza H, Coquet L, Leprince J, Jouenne T, Vaudry H, Rollins-Smith LA." Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae). DRAMP01639 GLWSTIKNVGKEAAIAAGKAALGAL 25 "Dermaseptin-1 (DShypo01, DPh-1; Frogs, amphibians, animals)" P84596 Not found Not found Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also has antiprotozoal activity against L. amazonensis. No hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.16963159]Gram-positive bacteria: Micrococcus luteus A270 (MIC=6 ?M), Staphylococcus aureus ATCC 6538 (MIC=6 ?M);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=6 ?M), Pseudomonas aeruginosa ATCC 14502 (MIC=6.6 ?M)." [Ref:16844081]Non-hemolytic activity upto 53 M against human red blood cells;##[Ref.16963159]Non-hemolytic activity at 6 M against erythrocytes Linear Free Amidation Free L [Ref.16844081]No cytotoxicity information found##[Ref.16963159]No cytotoxicity information found Not found 16844081##16963159 Biochem Biophys Res Commun. 2006 Sep 1;347(3):739-746.##Peptides. 2006 Dec;27(12):3092-3099. "Brand GD, Leite JR, de S?? Mandel SM, Mesquita DA, Silva LP, Prates MV, Barbosa EA, Vinecky F, Martins GR, Galasso JH, Kuckelhaus SA, Sampaio RN, Furtado JR Jr, Andrade AC, Bloch C Jr.##Concei???o K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC." Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).##Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis. DRAMP01643 GLWSTIKQKGKEAAIAAAKAAGQAALGAL 29 "Dermaseptin-5 (DShypo05, DS 01; Frogs, amphibians, animals)" P84600 Not found Not found Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also has antiprotozoal activity against L. amazonensis. No hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." [Ref.8306981]Gram-negative bacterium: Escherichia coli (MIC=6.4 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3.2 ?M). [Ref:8306981]Non-hemolytic activity against rabbit red blood cells. Linear Free Amidation Free L [Ref.12379643]No cytotoxicity information found##[Ref.17442605]No cytotoxicity information found Not found 12379643##17442605 J Biol Chem. 2002 Dec 20;277(51):49332-49340. ##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):336-343. "Brand GD, Leite JR, Silva LP, Albuquerque S, Prates MV, Azevedo RB, Carregaro V, Silva JS, S VC, Brand?o RA, Bloch C Jr. ##Leite JRSA, Brand GD, Silva LP, Kckelhaus SAS, Bento WRC, Arajo ALT, Martins GR, Lazzari AM, Bloch C Jr." "Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells. ##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity. " DRAMP01646 GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV 33 "Adenoregulin (Dermaseptin BII; Dermaseptin B2; Frogs, amphibians, animals)" "P31107, P80283" Belongs to the frog skin active peptide family (Dermaseptin subfamily) ADR Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Fountion: Enhances binding of agonists to adenosine A1 receptors, adenosine A2a receptors, alpha-2 adrenergic receptors and 5-hydroxytryptamine 1A receptors. Enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. Affects human behavior eliciting profound malaise, followed by listlessness and then euphoria. Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Lack hemolytic activity. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation at V33 (Amidation in vitro increases antimicrobial activity against some microorganisms such as T. album and S. cerevisia)." "[Ref.8306981]Fungi: Microsporum canis (IP 1194) (MIC=10 ?g/ml), Tricophyton rubrum (IP 1400-82) (MIC=15 ?g/ml), Arthroderma simii (IP 1063-74) (MIC=30 ?g/ml), Aspergillus fumigatus IP (1025-70) (MIC=125 ?g/ml), Aerornonas caviae (IP 67-16 T) (MIC=60 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 ?g/ml), Candida albicans (IP 884-65) (MIC=15 ?g/ml);##Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=15 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=30 ?g/ml)." [Ref:8306981]Lack hemolytic activity against rabbit red blood cells Linear Free Free Free L [Ref.8306981]No cytotoxicity information found##[Ref.1438301]No cytotoxicity information found##[Ref.7842473]No cytotoxicity information found##[Ref.8565049]No cytotoxicity information found Not found 8306981##1438301##7842473##8565049 "Eur J Biochem 1994, 219 (1-2):145-154.##Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-10963.##Cell Mol Neurobiol. 1994 Apr;14(2):133-157.##Cell Mol Neurobiol. 1995 Aug;15(4):465-493." "Mor, A, Nicolas, P.##Daly JW, Caceres J, Moni RW, Gusovsky F, Moos M Jr, Seamon KB, Milton K, Myers CW.##Shin Y, Moni RW, Lueders JE, Daly JW.##Moni RW, Romero FS, Daly JW." "Isolation and structure of novel defensive peptides from frog skin.##Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor.##Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx.##The amphiphilic peptide adenoregulin enhances agonist binding to A1-adenosine receptors and [35S]GTP gamma S to brain membranes." DRAMP01647 FLSLIPHIVSGVAALAKHLG 20 "DRP-PBN1 (Frogs, amphibians, animals)" No entry found Not found Not found Phyllomedusa bicolor "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: S. aureus (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.15222751]No cytotoxicity information found Not found 15222751 Biochemistry. 2004 Jul 6;43(26):8391-8409. "Vanhoye D, Bruston F, El Amri S, Ladram A, Amiche M, Nicolas P." "Membrane association, electrostatic sequestration, and cytotoxicity of Gly-Leu-rich peptide orthologs with differing functions." DRAMP01648 GLVTSLIKGAGKLLGGLFGSVTGGQS 26 "Dermaseptin-like PBN2 (DRP-PBN2; Plasticin-B1a; Frogs, amphibians, animals)" Q800R4 Not found Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Possesses a potent antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and fungi. Probably acts by disturbing membrane functions with its amphipathic structure." "Gram-negative bacteria: Escherichia coli B (MIC=1.5 ?M), Salmonella typhimurium (MIC=3.1 ?M), Salmonella enteritidis (MIC=1.5 ?M), Enterobacter cloacae (MIC=12.5 ?M), Klebsiella pneumoniae (MIC=0.8 ?M);##Gram-positive bacteria: Aerococcus viridans (MIC=3.1 ?M), Bacillus megaterium (MIC=0.8 ?M), Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus haemolyticus (MIC=0.8 ?M).##Fungi: Saccaromyces cerevisiae (MIC=3.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.12709067]No cytotoxicity information found##[Ref.15222751]No cytotoxicity information found Not found 12709067##15222751 Eur J Biochem. 2003 May;270(9):2068-2081.##Biochemistry. 2004 Jul 6;43(26):8391-8409. "Vanhoye D, Bruston F, Nicolas P, Amiche M.##Vanhoye D, Bruston F, El Amri S, Ladram A, Amiche M, Nicolas P." "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Membrane association, electrostatic sequestration, and cytotoxicity of Gly-Leu-rich peptide orthologs with differing functions." DRAMP01649 AMWKDVLKKIGTVALHAGKAALGAVADTISQ 31 "Dermaseptin-BI (Dermaseptin B1; Frogs, amphibians, animals)" P80282 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation (Potential)." "Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=15 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=30 ?g/ml).##Fungi: Tricophyton rubrum (IP 1400-82) (MIC=15 ?g/ml), Microsporum canis (IP 1194) (MIC=10?g/ml), Arthroderma simii (IP 1063-74) (MIC=30 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neofonnans (IP 962-67) (MIC=15 ?g/ml), Aspergillus fumigatus (IP 1025-70)(MIC=125 ?g/ml), Aerornonas caviae (IP 67-16 T) (MIC=60 ?g/ml), Candida albicans (IP 884-65) (MIC=15 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.8306981]No cytotoxicity information found##[Ref.8074751]No cytotoxicity information found Not found 8306981##8074751 Eur J Biochem. 1994 Jan 15;219(1-2):145-154.##J Biol Chem. 1994 Jul 8;269(27):17847-17852. "Mor A, Nicolas P.##Amiche M, Ducancel F, Mor A, Boulain JC, Menez A, Nicolas P." "Isolation and structure of novel defensive peptides from frog skin.##Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins." DRAMP01650 ALWKNMLKGIGKLAGQAALGAVKTLVGAE 29 "Dermaseptin-B3 (Dermaseptin BIII; Frogs, amphibians, animals)" P81485 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands." "Gram-negative bacteria: Pseudomonas aeruginosa CIP A22 (MIC=2.3 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=5 ?M), Escherichia coli ATCC 25922 (MIC=2.6 ?M), E. coli 54127 (MIC=2.3 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25293 (MIC=1.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.9614066]No cytotoxicity information found Not found 9614066 J Biol Chem. 1998 Jun 12;273(24):14690-14697. "Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A." "Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics." DRAMP01651 ALWKDILKNVGKAAGKAVLNTVTDMVNQ 28 "Dermaseptin-B4 (Dermaseptin BIV; Frogs, amphibians, animals)" P81486 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None "Function: Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus ATCC 25293 (MIC=1.3 ?M), S. aureus ATCC 25923 (MIC=3.0 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa CIP A22 (MIC=4.6 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=11.6 ?M), Escherichia coli ATCC 25922 (MIC=5.0 ?M), E. coli 54127 (MIC=2.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.9614066]No cytotoxicity information found Not found 9614066 J Biol Chem. 1998 Jun 12;273(24):14690-14697. "Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A." "Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics." DRAMP01668 ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ 34 "Dermaseptin-1 (DS I; Dermaseptin-S1, DS1; Frogs, amphibians, animals)" "P24302, P80277" Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa sauvagei (Sauvage's leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (CD) Not found None "Function: Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. This peptide could also inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). Tissue specificity: Expressed by the skin glands." "Fungi: Microsporum canis (IP 1194) (MIC=50 ?g/ml), Tricophyton rubrum (IP 1400-82) (MIC=100 ?g/ml), Arthroderma simii (IP 1063-74) (MIC=100 ?g/ml), Aspergillus fumigatus (IP 1025-70) (MIC=100 ?g/ml), Aerornonas caviae IP (67-16) T (MIC=50 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 ?g/ml), Candida albicans (IP 884-65) (MIC=60 ?g/ml); ##Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=5 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=200 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.1909573]No cytotoxicity information found##[Ref.8306981]No cytotoxicity information found Cell membrane 1909573##8306981 Biochemistry. 1991 Sep 10;30(36):8824-8830.##Eur J Biochem. 1994 Jan 15;219(1-2):145-154. "Mor A, Nguyen VH, Delfour A, Migliore-Samour D, Nicolas P.##Mor A, Nicolas P." "Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin.##Isolation and structure of novel defensive peptides from frog skin." DRAMP18386 SPKKTKPVKPKKVA 14 VK25 (histone derived; reptiles; animals) No entry found Not found Not found "blood plasma, Komodo dragon, Varanus komodoensis" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against P. eruginosa ATCC9027 (EC50 3.2 uM) and S. aureus ATCC 25923 (EC50 2.5 uM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28164707]No cytotoxicity information found Not found 28164707 J Proteome Res. 2017 Apr 7;16(4):1470-1482. "Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML." Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry DRAMP18387 KAAAAKKSPKKPKKPAAAKK 20 VK14 (histone derived;reptiles; animals) No entry found Not found Not found "blood plasma, Komodo dragon, Varanus komodoensis" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against P. eruginosa ATCC9027 (EC50 0.6 uM) and S. aureus ATCC 25923 (EC50 1.2 uM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28164707]No cytotoxicity information found Not found 28164707 J Proteome Res. 2017 Apr 7;16(4):1470-1482. "Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML" Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry DRAMP18388 AAGGVKKPKKAAAAKKSPKKPKKPAAA 27 VK13 (histone derived; reptiles; animals) No entry found Not found Not found "blood plasma, Komodo dragon, Varanus komodoensis" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against P. eruginosa ATCC9027 (EC50 0.9 uM) and S. aureus ATCC 25923 (EC50 1.0 uM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28164707]No cytotoxicity information found Not found 28164707 J Proteome Res. 2017 Apr 7;16(4):1470-1482. "Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML" Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry DRAMP18385 KKSCHTGLKKSAGWVIPIGTLVKNGIIVR 29 cOT2 (reptiles; animals) No entry found Not found Not found "Siamese crocodile, Crocodylus siamensis" "Antimicrobial, Antibacterial" Helix Not found None Comment: No comments found on DRAMP database "Active against E. coli ATCC 25922 (MIC 32 uM), V. cholerae (MIC 8 uM), Gram+ B. megaterium (MIC 8 uM) and B. pumilus TISTR 905 (MIC 16 uM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28159460]No cytotoxicity information found Not found 28159460 Biochim Biophys Acta Biomembr. 2017 May;1859(5):860-869. "Prajanban BO, Jangpromma N, Araki T, Klaynongsruang S" Antimicrobial effects of novel peptides cOT2 and sOT3 derived from Crocodylus siamensis and Pelodiscus sinensis ovotransferrins DRAMP01702 GLWSTIKNVGKEAAIAAGKAVLGSL 25 "Dermaseptin-H5 (Dermaseptin-like peptide 5, DMS5; Frogs, amphibians, animals)" Q1EJP4 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None MOA: Probably acts by disturbing membrane functions with its amphipathic structure (By similarity). "Gram-negative bacterium: Escherichia coliEscherichia coli ATCC 11775 (MIC=0.5 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (MIC=0.5 ?M), Micrococcus luteus ATCC 49732 (MIC=2.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17553595]No cytotoxicity information found Not found 17553595 Peptides. 2007 Jul;28(7):1331-1343. "Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S." A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea. DRAMP01721 HFLGKLVNLAKKIL 14 "[T5k]temporin-DRa (Frogs, amphibians, animals)" No entry found Not found Not found Rana draytonii "Antimicrobial, Antibacterial" Protein level Not found Not found None Comment: No comments found on DRAMP database "Clinical isolates: Propionibacterium acnes strain ATCC 11828 (MIC=6 ?M), P. acnes strain 32548 (MIC=6 ?M), P. acnes strain 33257 (MIC=12.5 ?M), P. acnes strain 50247 (MIC=3 ?M), P. acnes strain 18380 (MIC=12.5 ?M), P. acnes strain 15725 (MIC=6 ?M), P. acnes strain 29903 (MIC=12.5 ?M), P. acnes strain 31766 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free Mixed (5D-Lys) [Ref.22374306]No cytotoxicity information found Not found 22374306 Peptides. 2012 Apr;34(2):275-282. "Popovic S, Urbn E, Lukic M, Conlon JM." Peptides with antimicrobial and anti-inflammatory activities that have therapeutic potential for treatment of acne vulgaris. DRAMP02230 GFLDIINKLGKTFAGHMLDKIKCTIGTCPPSP 32 "Ranatuerin-3 (Frogs, amphibians, animals)" P82780 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix Not found None Function: Antibacterial activity against Gram-positive bacterium S.aureus. Has no detectable hemolytic activity. [Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M). [Ref.9784389] Have no detectable hemolytic activity at aconcentration of 20?g/ml against human red blood cell. Cyclic Free Free Disulfide bridge between Cys23 and Cys28. L [Ref.9784389]No cytotoxicity information found Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02231 FLPFIARLAAKVFPSIICSVTKKC 24 "Ranatuerin-4 (Frogs, amphibians, animals)" P82819 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix Not found None Function: Antibacterial activity against Gram-positive bacterium S.aureus. Has no detectable hemolytic activity. [Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=55 ?M). [Ref.9784389] Have no detectable hemolytic activity at aconcentration of 20?g/ml against human red blood cell. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bridge between Cys18 and Cys24. L [Ref.9784389]No cytotoxicity information found Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP01731 FLPIAGKLLSGLSGLL 16 "Temporin-ALd (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALd exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1.25 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=15 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)." [Ref:19843479]12% hemolytic activity at 100 g/mL against rabbit red blood cells Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01732 FFPIVGKLLFGLSGLL 16 "Temporin-ALe (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALe exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.25 ?g/mL), Bacillus pumilus (MIC=5 ?g/mL), Bacillus cereus (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1.25 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=15 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)." [Ref:19843479]10% hemolytic activity at 100 g/mL against rabbit red blood cells Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01733 FFPIVGKLLSGLSGLL 16 "Temporin-ALf (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALf exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=5 ?g/mL), Bacillus cereus (MIC=30 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=2.5 ?g/mL), Bacillus dysenteriae (MIC=5 ?g/mL), Acinetobacter calcoaceticus (MIC=30 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)." [Ref:19843479]7% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01734 FFPIVGKLLFGLFGLL 16 "Temporin-ALg (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALg exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=2.5 ?g/mL), Bacillus cereus (MIC=30 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?g/mL), Bacillus dysenteriae (MIC=10 ?g/mL), Acinetobacter calcoaceticus (MIC=30 ?g/mL), Psecdomonas aeruginosa (MIC=7.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=1.25 ?g/mL)." [Ref:19843479]16% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01735 FLPIVGKLLSGLSGLS 16 "Temporin-ALh (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALh exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 ?g/mL), Bacillus pumilus (MIC=7.5 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?g/mL), Bacillus dysenteriae (MIC=20 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=2.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=2.5 ?g/mL)." [Ref:19843479]13% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01736 FFPIVGKLLSGLL 13 "Temporin-ALi (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALi exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=7.5 ?g/mL), Bacillus pumilus (MIC=7.5 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=7.5 ?g/mL), Bacillus dysenteriae (MIC=20 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=5 ?g/mL)." [Ref:19843479]21% hemolytic activity at 100 g/mL against rabbit red blood cells Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01737 FFPIVGKLLFGLL 13 "Temporin-ALj (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALg exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=7.5 ?g/mL), Bacillus pumilus (MIC=15 ?g/mL), Bacillus cereus (MIC=75 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=15 ?g/mL), Bacillus dysenteriae (MIC=30 ?g/mL), Acinetobacter calcoaceticus (MIC=60 ?g/mL), Psecdomonas aeruginosa (MIC=7.5 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=5 ?g/mL)." [Ref:19843479]19% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP01738 FFPIVGKLLS 10 "Temporin-ALk (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Temporin-ALk exhibits hemolytic activity against rabbit red blood cells. "[Ref.19843479]Gram-positive bacterium: Staphylococcus aureus ATCC2592 (MIC=15 ?g/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 ?g/mL), Bacillus dysenteriae (MIC=60 ?g/mL), Acinetobacter calcoaceticus (MIC=75 ?g/mL), Psecdomonas aeruginosa (MIC=25 ?g/mL);##Yeast: Candida albicans ATCC2002 (MIC=15 ?g/mL)." [Ref:19843479]25% hemolytic activity at 100 g/mL against rabbit red blood cells. Linear Free Amidation Free L [Ref.19843479]No cytotoxicity information found Not found 19843479 Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76. "Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R." "Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis." DRAMP02229 GLFLDTLKGAAKDVAGKLEGLKCKITGCKLP 31 "Ranatuerin-2 (Frogs, amphibians, animals)" P82742 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix Not found None Function: Antibacterial activity against Gram-positive bacterium S.aureus. Has no detectable hemolytic activity. [Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M). [Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20?g/ml against human red blood cell. Cyclic Free Free Disulfide bond between Cys23 and Cys28. L No cytotoxicity information found Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP01750 FLPLVGKILSGLI 13 "Temporin-1PLa (Frogs, amphibians, animals)" A7WNV7 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None Function: Antimicrobial activity against the Gram-positive bacteria: S. aureus. Tissue specificity: Expressed by the skin glands. PTM: Isoleucine amide at position 13. Gram-positive bacterium: Staphylococcus aureus (MIC=70 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.11087945]No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01751 FLPGLIAGIAKML 13 "Temporin-LT1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Temporin-LT1 shows hemolytic activities against rabbit red blood cells (LD50>100 ?g/ml). "[Ref.19340924]Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ?M), Bacillus subtilis (MIC=25 ?M)." [Ref:19340924]LD50>100 ?g/ml against rabbit red blood cells Linear Free Amidation Free L [Ref.19340924]No cytotoxicity information found Not found 19340924 Biochimie. 2009 Apr;91(4):540-547. "Wang H, Yan X, Yu H, Hu Y, Yu Z, Zheng H, Chen Z, Zhang Z, Liu J." "Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae)." DRAMP01752 FLPIALKALGSIFPKIL 17 "Temporin-LT2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Function: Temporin-LT2 shows hemolytic activities against rabbit red blood cells (LD50>200 ?g/ml). "[Ref.19340924]Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ?M), Bacillus subtilis (MIC=50 ?M)." [Ref:19340924]LD50>200 ?g/ml against rabbit red blood cells Linear Free Amidation Free L [Ref.19340924]No cytotoxicity information found Not found 19340924 Biochimie. 2009 Apr;91(4):540-547. "Wang H, Yan X, Yu H, Hu Y, Yu Z, Zheng H, Chen Z, Zhang Z, Liu J." "Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae)." DRAMP01753 FVDLKKIANIINSIFGK 17 "Temporin-1CEa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chensinensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Alpha helix Not found None Function: Temporin-1CEa exhibits the greatest ability to inhibit the growth of MCF-7 cells. Also temporin-1CEa shows hemolytic effect to human erythrocytes and has no significant cytotoxicity to normal HUVSMCs at concentrations showed potent antitumor activity. "[Ref.21871946]Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 ?M), Bacillus cereus (MIC=14.4 ?M), Streptococcus lactis (MIC=14.4 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M)." [Ref:21871946]LD50=99.08 M against human erythrocytes Linear Free Amidation Free L [Ref.19341344]No cytotoxicity information found##[Ref.21871946]No determined cytotoxic against SMCs at the concentration between 20-60 M. Not found 21871946##19341344 Biochimie. 2012 Feb;94(2):434-441.##Zoolog Sci. 2009 Mar;26(3):220-226. "Wang C, Li HB, Li S, Tian LL, Shang DJ.##Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y." "Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis).##Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis." DRAMP01754 ILPILSLIGGLLGK 14 "Temporin-1CEb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chensinensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus (MIC=41 ?M), Bacillus cereus (MIC=41 ?M), Streptococcus lactis (MIC=41 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19341344]No cytotoxicity information found Not found 19341344 Zoolog Sci. 2009 Mar;26(3):220-226. "Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y." "Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis." DRAMP01755 FLGALAKIISGIF 13 "Temporin-1TSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tsushimensis (Tsushima brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16413829]No cytotoxicity information found Not found 16413829 Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. "Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. DRAMP01759 FLSAITSLLGKLL 13 "Temporin-1SPb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15556063]No cytotoxicity information found Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01764 FLPILGKLLSGIL 13 "Temporin-1TGa (Frogs, amphibians, animals)" Q2PGA8 Belongs to the frog skin active peptide family (Brevinin subfamily) tmpTGa Rana tagoi (Tago frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M).##Yeast: Candida albicans. No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.12804591]No cytotoxicity information found##[Ref.16675060]No cytotoxicity information found Not found 12804591##16675060 Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.##Peptides. 2006 Sep;27(9):2124-2128. "Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, P??l T.##Iwamuro S, Nakamura M, Ohnuma A, Conlon JM." "A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties.##Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi." DRAMP01765 AVDLAKIANKVLSSLF 16 "Temporin-1TGb (Frogs, amphibians, animals)" Q2PGA7 Belongs to the frog skin active peptide family (Brevinin subfamily) tmpTGb Rana tagoi (Tago frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC>150 ?M);##Gram-negative bacterium: Escherichia coli (MIC=37.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16675060]No cytotoxicity information found Not found 16675060 Peptides. 2006 Sep;27(9):2124-2128. "Iwamuro S, Nakamura M, Ohnuma A, Conlon JM." Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi. DRAMP01766 FLPVILPVIGKLLSGIL 17 "Temporin-1TGc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tagoi (Tago's brown frog); also Rana sakuraii "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=37.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC>150 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16675060]No cytotoxicity information found Not found 16675060 Peptides. 2006 Sep;27(9):2124-2128. "Iwamuro S, Nakamura M, Ohnuma A, Conlon JM." Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi. DRAMP01768 FLPVILPVIGKLLNGIL 17 "Temporin-1SKa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sakuraii (stream brown frog) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacteria: Escherichia coli (MIC>50 ?M);##Gram-negative bacteria: Staphylococcus aureus (MIC=25 ?M).##Fungi: Candida albicans (MIC>50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17174009]No cytotoxicity information found Not found 17174009 Peptides. 2007 Mar;28(3):505-514. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii. DRAMP18384 KKSCHTGLDRSAGWVIPIGTLVKKAILPWDRK 32 sOT2 (reptiles; animals) No entry found Not found Not found "Chinese softshell turtle, Pelodiscus sinensis" "Antimicrobial, Antibacterial" Helix Not found None Comment: No comments found on DRAMP database "Active against E. coli ATCC 25922 (MIC 28 uM), V. cholerae (MIC 7 uM), Gram+ B. megaterium (MIC 7 uM) and B. pumilus TISTR 905 (MIC 7 uM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.28159460]No cytotoxicity information found Not found 28159460 Biochim Biophys Acta Biomembr. 2017 May;1859(5):860-869. "Prajanban BO, Jangpromma N, Araki T, Klaynongsruang S" Antimicrobial effects of novel peptides cOT2 and sOT2 derived from Crocodylus siamensis and Pelodiscus sinensis ovotransferrins DRAMP01771 FLPLLASLFSRLL 13 "Temporin-1Oa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana ornativentris (Japanese mountain brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=70 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17147973]No cytotoxicity information found Not found 17147973 Peptides. 2007 Mar;28(3):524-532. "Ohnuma A, Conlon JM, Yamaguchi K, Kawasaki H, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Japanese mountain brown frog Rana ornativentris: evidence for polymorphism among preprotemporin mRNAs. DRAMP01773 FLPLLASLFSRLF 13 "Temporin-1Oc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana ornativentris (Japanese mountain brown frog) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17147973]No cytotoxicity information found Not found 17147973 Peptides. 2007 Mar;28(3):524-532. "Ohnuma A, Conlon JM, Yamaguchi K, Kawasaki H, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Japanese mountain brown frog Rana ornativentris: evidence for polymorphism among preprotemporin mRNAs. DRAMP01775 FLSGIVGMLGKLFGK 15 "Temporin-1Sa (Frogs, amphibians, animals)" B3KYH4 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-1Sa Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Activity against Gram-positive and Gram-negative bacteria, and has hemolytic activity against human erythrocytes." "[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3 ?M), Enterococcus faecalis ATCC 29212 (MIC=10 ?M), Bacillus megaterium (MIC=2 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10 ?M), Escherichia coli ATCC 35218 (MIC=10 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=31 ?M);##Fungi: Candida albicans ATCC 90028 (MIC=16 ?M), Candida parapsilosis ATCC 22019 (MIC=31 ?M), Saccharomyces cerevisiae (MIC=8 ?M)." [Ref:18584916]LC50=25 M against human erythrocytes Linear Free Amidation Free L [Ref.18584916]No cytotoxicity information found Not found 18584916 Peptides. 2008 Sep;29(9):1526-1523. "Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A" "Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica." DRAMP01776 FLPIVTNLLSGLLGK 15 "Temporin-1Sb (Temporin-SHb; Frogs, amphibians, animals)" B3KYH5 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-1Sb Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Activity against Gram-positive and Gram-negative bacteria, and has strong hemolytic activity against human erythrocytes." "[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=58 ?M), Enterococcus faecalis ATCC 29212 (MIC>116 ?M), Bacillus megaterium (MIC=46 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=231 ?M), Escherichia coli ATCC 35218 (MIC>116 ?M);##Fungi: Aspergillus flavus (MIC=58 ?M)." [Ref:18584916]LC50>116 M against human erythrocytes Linear Free Amidation Free L [Ref.18584916]No cytotoxicity information found Not found 18584916 Peptides. 2008 Sep;29(9):1526-1523. "Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A" "Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica." DRAMP01777 FLSHIAGFLSNLFGK 15 "Temporin-1Sc (Temporin-SHc; Frogs, amphibians, animals)" B3KYH6 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-1Sc Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and has hemolytic activity against human erythrocytes." "[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC>80 ?g/ml), Bacillus megaterium (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=161 ?g/ml), Escherichia coli ATCC 35218 (MIC>80 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>161 ?g/ml);##Fungi: Aspergillus flavus (MIC=10 ?g/ml), Candida albicans ATCC 90028 (MIC=20 ?g/ml), Candida parapsilosis ATCC 22019 (MIC=20 ?g/ml), Saccharomyces cerevisiae (MIC=10 ?g/ml)." [Ref:18584916]LC50>80 M against human erythrocytes Linear Free Amidation Free L [Ref.18584916]No cytotoxicity information found Not found 18584916 Peptides. 2008 Sep;29(9):1526-1523. "Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A" "Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica." DRAMP01779 FFFLSRIFGK 10 "Temporin-SHf (Frogs, amphibians, animals)" D4YWD1 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-SHf Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25-200 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.20308076]No cytotoxicity information found Not found 20308076 J Biol Chem. 2010 May 28;285(22):16880-16892. "Abbassi F, Lequin O, Piesse C, Goasdoue N, Foulon T, Nicolas P, Ladram A." "Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide." DRAMP01780 FLSGIVGMLGKLF 13 "Temporin-SHa (Temporin-1Sa; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Pelophylax saharica (North Africa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Bacillus megaterium (MIC=2 ?M);##Gram-negative bacterium: Escherichia coli (MIC=10 ?M).##Yeast: Candida albicans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.31614561]Display cytotoxic against human gastric cells(N87 cell:IC50=1558 324M) Not found 31614561 Biomolecules. 2019 Oct 11;9(10):598. "Olleik H, Baydoun E, Perrier J, Hijazi A, Raymond J, Manzoni M, Dupuis L, Pauleau G, Goudard Y, Villon B, Goin G, Sockeel P, Choudhary MI, Pasquale ED, Nadeem-Ul-Haque M, Ali H, Khan AI, Shaheen F, Maresca M. " Temporin-SHa and Its Analogs as Potential Candidates for the Treatment of Helicobacter pylori. DRAMP01782 FFPLVLGALGSILPKIF 17 "Temporin-LTa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii (broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacteria: Staphylococcus aureus (MIC=20 ?g/ml) and Bacillus subtilis (MIC=10 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19022312]No cytotoxicity information found Cell membrance 19022312 Peptides. 2009 Feb;30(2):273-282. "Wang H, Lu Y, Zhang X, Hu Y, Yu H, Liu J, Sun J." "The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae)." DRAMP01783 FIITGLVRGLTKLF 14 "Temporin-LTb (Frogs, amphibians, animals)" B9UYA1 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii (broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ?g/ml) and Bacillus subtilis (MIC=25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19022312]No cytotoxicity information found Cell membrance 19022312 Peptides. 2009 Feb;30(2):273-282. "Wang H, Lu Y, Zhang X, Hu Y, Yu H, Liu J, Sun J." "The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae)." DRAMP01784 SLSRFLSFLKIVYPPAF 17 "Temporin-LTc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii (broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Not found Not found Not found None Comment: A mutant of the peptide is also HIV inhibitory (Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346). "Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?g/ml), Bacillus subtilis (MIC=50 ?g/ml);##Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19022312]No cytotoxicity information found Not found 19022312 Peptides. 2009 Feb;30(2):273-282. "Wang H, Lu Y, Zhang X, Hu Y, Yu H, Liu J, Sun J." "The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae)." DRAMP01785 IPPFIKKVLTTVF 13 "Temporin-CPa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates capito (New World frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: For this series of peptides, there were not enough material for antimicrobial assays. It displayed hemolytic activity (human red blood cells) at LC50=220 uM. " [Ref.19635516]Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=50 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=25 ?M). [Ref:19635516]LC50=220 M against human erythrocytes Linear Free Amidation Free L [Ref.19635516]No cytotoxicity information found Not found 19635516 Peptides. 2009 Oct;30(10):1775-1781. "Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). DRAMP01787 AILTTLANWARKFL 14 "Temporin-HN1 (Frogs, amphibians, animals)" E7EKD0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has hemolytic activity against washed human erythrocytes (IC50=75 ?M). "[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=37.5 ?M), Staphylococcus carnosus KHS (MIC=37.5 ?M), Bacillus licheniformis X39 (MIC=19 ?M), Rhodococcus rhodochrous X15 (MIC=4.8 ?M);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=75 ?M);##Fungi: Slime mould 090223 (MIC=19 ?M), Candida albicans ATCC2002 (MIC=75 ?M)." [Ref:22450466]IC50=75 ?M against washed human erythrocytes Linear Free Amidation Free L [Ref.22450466]No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP01788 NILNTIINLAKKIL 14 "Temporin-HN2 (Frogs, amphibians, animals)" E7EKD4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=4.8 ?M), Staphylococcus carnosus KHS (MIC=19 ?M), Bacillus licheniformis X39 (MIC=19 ?M),Rhodococcus rhodochrous X15 (MIC=2.4 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=37.5 ?M).##Fungi: Slime mould 090223 (MIC=9.5 ?M) and Candida albicans ATCC2002 (MIC=9.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.22450466]No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP01789 FLSSIGKILGNLL 13 "Temporin-1Va (Temporin 1Va; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: It also has weak hemolytic activty. "[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=10 ?M), S. aureus (MRSA) T7/20 (MIC=20 ?M), S. epidermidis RP62A (MIC=20 ?M), Enterococcus faecalis ATCC 29212 (MIC=40 ?M), Streptococcus group B HNTCC 80130 (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=40 ?M), Klebsiella pneumoniae KK3 9904 (MIC=80 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=160 ?M), Enterobacter cloacae HNTCC 53001 (MIC=40 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=160 ?M)." [Ref:15996769]LD50=120 M against washed human erythrocytes Linear Free Amidation Free L [Ref.15996769]No cytotoxicity information found Not found 15996769 Regul Pept. 2005 Nov;131(1-3):38-45. "Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR." "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP01790 FLSIIAKVLGSLF 13 "Temporin-1Vb (Temporin 1Vb; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None Function: It also has weak hemolytic activty. "[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=5 ?M), S. aureus (MRSA) T7/20 (MIC=10 ?M), S. epidermidis RP62A (MIC=5 ?M), Enterococcus faecalis ATCC 29212 (MIC=20 ?M), Streptococcus group B HNTCC 80130 (MIC=20 ?M)." [Ref:15996769]LD50=30 M against washed human erythrocytes Linear Free Amidation Free L [Ref.15996769]No cytotoxicity information found Not found 15996769 Regul Pept. 2005 Nov;131(1-3):38-45. "Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR." "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP01791 FLPLVTMLLGKLF 13 "Temporin-1Vc (Temporin 1Vc; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: It also has weak hemolytic activty. "[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=5 ?M), S. aureus (MRSA) T7/20 (MIC=10 ?M), S. epidermidis RP62A (MIC=10 ?M), Enterococcus faecalis ATCC 29212 (MIC=40 ?M), Streptococcus group B HNTCC 80130 (MIC=40 ?M);##Gram-negative bacteria: Klebsiella pneumoniae KK3 9904 (MIC=80 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=160 ?M), Enterobacter cloacae HNTCC 53001 (MIC=40 ?M)." [Ref:15996769]LD50=30 M against washed human erythrocytes Linear Free Amidation Free L [Ref.15996769]No cytotoxicity information found Not found 15996769 Regul Pept. 2005 Nov;131(1-3):38-45. "Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR." "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP01807 FLPLVLGALSGILPKIL 17 "Temporin-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=4.69 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa PAO1 (MIC=4.7 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01808 FFPLLFGALSSHLPKLF 17 "Temporin-RN3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=3.75 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa PAO1 (MIC=3.75 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01811 FLKPLFNAALKLLP 14 "Temporin-Ra (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana ridibunda (marsh frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "At 60 ug/ml, the peptide showed about 1.3% hemolysis." "Gram-negative bacteria: Escherichia coli (MIC=24.2 ?g/ml), Klebsiella pneumoniae PTCC 1388 (MIC=31.2 ?g/ml);##Gram-positive bacteria: Streptococcus dysgalactiae PTCC 1074 (MIC=33.2 ?g/ml), Streptococcus agalactiae PTCC 1365 (MIC=24.7 ?g/ml) and Staphylococcus aureus PTCC 1431 (MIC=35.2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.21956830]No cytotoxicity information found Not found 21956830 J Pept Sci. 2012 Jan;18(1):10-16. "Asoodeh A, Zardini HZ, Chamani J." "Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda)." DRAMP01812 FLPVLAGVLSRA 12 "Temporin-Rb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana ridibunda (marsh frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "At 60 ug/ml, the peptide showed about 1.1% hemolysis. " "Gram-positive bacteria: Streptococcus dysgalactiae PTCC 1074 (MIC=21.8 ?g/ml), Streptococcus agalactiae PTCC 1365 (MIC=30.5 ?g/ml), Staphylococcus aureus PTCC 1431 (MIC=42.1 ?g/ml), Staphylococcus typhimurium (MIC=31.8 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=34.5 ?g/ml), Klebsiella pneumoniae PTCC 1388 (MIC=35.1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.21956830]No cytotoxicity information found Not found 21956830 J Pept Sci. 2012 Jan;18(1):10-16. "Asoodeh A, Zardini HZ, Chamani J." "Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda)." DRAMP01815 FLPLLFGAISHLL 13 "Temporin-GH (AMP-5; Frogs, amphibians, animals)" P84858 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana guentheri (Gunther's frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Active against the Gram-positive bacteria S. aureus FDA209P and B. subtilis ATCC 6633, but not active against the Gram-negative bacteria E. coli or the fungus C. albicans. Tissue specificity: Expressed by the skin glands. PTM: Leucine amide at position 13." "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=44.3 ?g/ml), Bacillus subtilis ATCC 6633 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.16979798]No cytotoxicity information found Not found 16979798 Peptides. 2006 Dec;27(12):3077-3084 "Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ." Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. DRAMP01816 FLPIIGKLLSGLL 13 "Temporin-1CSb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=128 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17451843]No cytotoxicity information found Not found 17451843 Peptides 2007; 28: 1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP01817 FLPLVTGLLSGLL 13 "Temporin-1CSc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC>128 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=64 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17451843]No cytotoxicity information found Not found 17451843 Peptides 2007; 28: 1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP01818 NFLGTLVNLAKKIL 14 "Temporin-1CSd (Temporin-1DRb; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=64 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17451843]No cytotoxicity information found Not found 17451843 Peptides 2007; 28: 1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP03510 KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK 37 Cecropin A P01507 cecropin Not found Hyalophora cecropia "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha-helix Not found 1D9J Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. "[Ref.7140755] Gram-negative bacterium: Escherichia coli D21 (LC=0.19 ?M), Escherichia coli D31 (LC=0.21 ?M), Serratia marcescens Db11 (LC=4.2 ?M), Serratia marcescens Db1108 (LC=2.5 ?M), Serratia marcescens Db1121 (LC=4.4 ?M), Serratia marcescens Strain 122 (LC=3.2 ?M), Pseudomonas aeruginosa OT97 (LC=4.8 ?M), Xenorhabdus nematophilus Xn21 (LC=1.4 ?M).##[Ref.29925795]Gram-negative bacterium:Escherichia coli CVCC 245 (MIC=4.2 0.35g/mL);##Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC=198 10.1g/mL),L. mono. CVCC 1599 (MIC=64.5 3.20g/mL)" [Ref.29925795] 50% hemolysis at 169 8.20 g/ml against sheep red blood cells. Linear Free Amidation Free L [Ref.29925795]No cytotoxicity information found##[Ref.7140755]No cytotoxicity information found Not found 7140755##29925795 Eur J Biochem. 1982 Sep;127(1):207-217.##Molecules. 2018 Jun 20;23(6):1491. "Hultmark D, Engstr?m A, Bennich H, Kapur R, Boman HG.##Wei X, Wu R, Zhang L, Ahmad B, Si D, Zhang R." "Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae.##Expression, Purification, and Characterization of a Novel Hybrid Peptide with Potent Antibacterial Activity" DRAMP01391 GCSRWIIGIHGQICRD 16 "Odorranain-U1 (OdU1; Frogs, amphibians, animals)" A6MBS4 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-U1 adopts 60.2% None Function: Odorranain-U1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC>100 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=75.00 g/ml), Bacillus subtilis (MIC=9.37 g/ml).##Yeast: Candida albicans (MIC=9.37 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01832 FLPGLLAGLL 10 "Temporin-Eca (Frogs, amphibians, animals)" C0HJB9 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Euphlyctis cyanophlyctis (Skittering frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml, respectively. Tissue specificity: Expressed by the skin glands." "[Swiss_Prot Entry C0HJB9]Gram-negative bacteria: Escherichia coli HP101BA (MIC=12.3 ?M), Klebsiella pneumoniae PTCC1388 (MIC=9.8 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=8.3 ?M), Staphylococcus aureus PTCC1431 (MIC=10.6 ?M)." [Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Int. J. Pept. Res. Ther. 2012;18:107-115. "Asoodeh A, Ghorani-Azam A, Chamani JK." Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis. DRAMP01833 RAGLKFPVGRVHRLLR 16 "Buforin-EC (Frogs, amphibians, animals)" C0HJB7 Belongs to the histone H2A family Not found Euphlyctis cyanophlyctis (Skittering frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml, respectively. Tissue specificity: Expressed by the skin glands." "[Swiss_Prot Entry C0HJB7]Gram-negative bacteria: Escherichia coli HP101BA (MIC=9.6 ?M), Klebsiella pneumoniae PTCC1388 (MIC=10.6 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=6.0 ?M), Staphylococcus aureus PTCC1431 (MIC=8.1 ?M)." [Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Int. J. Pept. Res. Ther. 2012;18:107-115. "Asoodeh A, Ghorani-Azam A, Chamani JK." Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis. DRAMP01834 FLNALKNFAKTAGKRLKSLLN 21 "Cyanophlyctin (Frogs, amphibians, animals)" C0HJB8 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Euphlyctis cyanophlyctis (Skittering frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Has no or very limited (<3%) hemolytic activity at concentrations of 15 ?g/ml and 60 ?g/ml. Tissue specificity: Expressed by the skin glands." "[Swiss_Prot Entry C0HJB8]Gram-negative bacteria: Escherichia coli HP101BA (MIC=6.4 ?M), Klebsiella pneumoniae PTCC1388 (MIC=7.3 ?M);##Gram-positive bacteria: Micrococcus luteus PTCC1625 (MIC=4.7 ?M), Staphylococcus aureus PTCC1431 (MIC=5.3 ?M)." [Ref.Int J Pept Res Ther(2012)18;107.]<3% hemolytic activity at 60 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Int. J. Pept. Res. Ther. 2012;18:107-115. "oodeh A, Ghorani-Azam A, Chamani JK." Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis. DRAMP01840 GFRDVLKGAAKAFVKTVAGHIAN 23 "Ascaphin-1 (Frogs, amphibians, animals)" P0CJ25 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: Asparagine amide at position 23. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M). [Ref.15207717]HC50>200 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01842 GFRDVLKGAAKAFVKTVAGHIANI 24 "Ascaphin-3 (Frogs, amphibians, animals)" P0CJ27 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M). [Ref.15207717]HC50>200 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01844 GIKDWIKGAAKKLIKTVASNIANQ 24 "Ascaphin-5 (Frogs, amphibians, animals)" P0CJ29 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. "[Ref.15207717]Gram-negative bacteria: Escherichia coli (MIC=6 ?M), Pseudomonas aeruginosa (MIC=13 ?M), Enterobacter cloacae (MIC=6 ?M), Klebsiella pneumoniae (MIC=13 ?M), Proteus mirabilis (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?M), Staphylococcus epidermidis (MIC=13 ?M), Enterococcus faecalis (MIC>100 ?M), Streptococcus Group B (MIC=6 ?M);##Yeast: Candida albicans (MIC=100 ?M)." [Ref.15207717]Not found Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01846 GFKDWIKGAAKKLIKTVASSIANQ 24 "Ascaphin-7 (Frogs, amphibians, animals)" P0CJ31 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Has a very weak hemolytic activity. Tissue specificity: Expressed by the skin glands. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M). [Ref.15207717]HC50>200 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01847 GFKDLLKGAAKALVKTVLF 19 "Ascaphin-8 (Frogs, amphibians, animals)" P0CJ32 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Not found Not found None Function: Antimicrobial peptide that shows similar potency against Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: Phenylalanine amide at position 19. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M). [Ref.15207717]HC50=50 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01849 DSMGAVKLAKLLIDKMKCEVTKAC 24 "Jindongenin-1a (JD1a; Frogs, amphibians, animals)" G3ETQ2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops jingdongensis (Chinese torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Also displays antifungal activity against C. albicans ATCC 2002. Has hemolytic activity, low cytotoxicity and low antioxidant activity." "[Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=17 ?M), Enterococcus faecalis ATCC29212 (MIC=60 ?M), Staphylococcus aureus (IS 10#)(MIC=40 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=10 ?M), Enterobacter cloacae ATCC13047 (MIC=40 ?M), Klebsiella pneumoniae ATCC700603 (MIC=15 ?M), Bacillus pyocyaneus CMCCB1010 (MIC=17 ?M), Pseudomonas aeruginosa ATCC27853 (MIC=23 ?M), Bacillus dysenteriae (MIC=40 ?M);##Yeast: Candida albicans ATCC2002 (MIC=60 ?M)." [Ref.21816202] IC50=150 M against washed human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.21816202] Cytotoxicity: the K562 (IC50=46M)and HT29 mammalian cell lines(IC50=40M). Not found 21816202 Biochimie. 2012 Feb;94(2):328-334. "Chen Z, Yang X, Liu Z, Zeng L, Lee W, Zhang Y." "Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis." DRAMP01869 FFPIIAGMAAKLIPSLFCKITKKC 24 "Brevinin-1SPa (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M);##Yeast: Candida albicans (MIC=7 ?M). [Ref.15556063]HC50=7 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01870 FLPIIAGMAAKVICAITKKC 20 "Brevinin-1SPb (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes (HC50=6 ?M). [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=13 ?M);##Yeast: Candida albicans (MIC=25 ?M). [Ref.15556063]HC50=25 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01872 FFPIIAGMAAKVICAITKKC 20 "Brevinin-1SPd (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 ?M);##Yeast: Candida albicans (MIC=8 ?M). [Ref.15556063]HC50=8 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01873 GIWDTIKSMGKVFAGKILQNL 21 "Brevinin-2-related peptide (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. Sequence similarity: This peptide shows limited structural similarity with the N-terminal region of brevinin-2 peptides previously isolated from R. temporaria skin but lacks the C-terminal cyclic heptapeptide domain associated with this family. PTM: C-terminal amidation." [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M);##Yeast: Candida albicans (MIC=70 ?M). [Ref.15556063]HC50=70 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP04213 KKLFKKILKYL 11 BP100 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Alpha helix The peptide adopted with positively charged residues on one face and the hydrophobic residues on the opposite face of the helix None Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Has hemolytic activity. [Ref.29750913] Gram-negative bacteria:Escherichia coli(ATCC 25922)(MIC=2 M);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=2M);Bacillus subtilis(PY79)(MIC=2M) [Ref.29750913] 10% hemolysis at 64M against human red blood cell Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 29750913 Biochim Biophys Acta. 2018 Aug;1860(8):1502-1516. "Carretero GPB, Saraiva GKV, Cauz ACG, Rodrigues MA, Kiyota S, Riske KA, Dos Santos AA, Pinatto-Botelho MF, Bemquerer MP, Gueiros-Filho FJ, Chaimovich H, Schreier S, Cuccovia IM." "Synthesis, biophysical and functional studies of two BP100 analogues modified by a hydrophobic chain and a cyclic peptide." DRAMP03571 LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 37 LL-37 "P49913,Q71SN9" Belongs to the cathelicidin family CAMP Human lysosomes of polymorphonuclear leukocytes "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Alpha helix The peptide adopted 1 helices and 30 residues and a curved amphipathic helix-bend-helix motif spanning residues 2-31 followed by a disordered C-terminal tail. The helical bend is located between residues Gly-14 and Glu-16. 2K6O resolved by NMR Function:Antibacterial activity against the Gram-positive and Gram-negative bacteria. Has hemolytic activity. [Ref.29859288] Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=25??0 g/ml);ESBL-producing Escherichia coli(MIC=33.3??14.4g/ml);NDM-1 producing Acinetobacter baumannii(MIC=20.8??7.2 g/ml);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=133.3??57.7g/ml);##Fungi:Candida albicans (ATCC 90028)(MIC>400g/ml) [Ref.29859288] 2.9??0.7% Hemolysis at 500g/ml against human red blood cell Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 29859288 Gene. 2018 May 30. pii: S0378-1119(18)30617-6. "Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S." Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. DRAMP01748 FFPIVGKRLYGLL 13 "Temporin-AJ8 (Frogs, amphibians, animals)" K7Z903 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops jingdongensis (torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Shows antimicrobial abilities against microorganisms including Gram-negative and Gram-positive bacteria, and fungi. Has hemolytic activity." "[Ref.22828809] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=70 g/ml), B. dysenteriae(MIC=18.75 g/ml) ;## Gram-positive bacteria: Staphylococcus aureus ATCC 2592(MIC=4.7 g/ml), Bacillus subtilis ATCC 6633(MIC=9.38 g/ml);## Yeast: Candida albicans ATCC 2002(MIC=37.5 g/ml)." "[Ref.22828809] 1.79% hemolysis at 25g/ml, 5.22% hemolysis at 50g/ml, 7.92% hemolysis at 100g/ml, 10.85% hemolysis at 200g/ml against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22828809 Amino Acids. 2012 Jul 25. "He X, Yang S, Wei L, Liu R, Lai R, Rong M." "Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis." DRAMP01879 GAFGDLLKGVAKEAGMKLLNMAQCKLSGKC 30 "Brevinin-2LTa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2 ?M), Bacillus licheniformis X39 (MIC=8 ?M), Staphylococcus carnosus KHS (MIC=2 ?M), Rhodococcus rhodochrous X15 (MIC=0.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=32.5 ?M), Serratia rubidaea X01 (MIC=130 ?M), Pseudomonas aeruginosa 1.50 (MIC=65 ?M), Psychrobacter faecalis X29 (MIC=0.5 ?M)." [Ref.22426384] LD50=520 M against human erythrocytes Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01880 SILDKIKNVALGVARGAGTGILKALLCKLDKSC 33 "Brevinin-2LTb (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.8 ?M), Bacillus licheniformis X39 (MIC=3.8 ?M), Staphylococcus carnosus KHS (MIC=1.9 ?M), Rhodococcus rhodochrous X15 (MIC=1.9 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 ?M), Serratia rubidaea X01 (MIC=60 ?M), Pseudomonas aeruginosa 1.50 (MIC=30 ?M), Psychrobacter faecalis X29 (MIC=1.9 ?M)." [Ref.22426384] LD50=480 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01881 GVLDTFKDVAIGVAKGAGTGVLKALLCKLDKSC 33 "Brevinin-2LTc (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=60 ?M), Rhodococcus rhodochrous X15 (MIC=30 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=15 ?M)." [Ref.22426384] LD50>480 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01885 FFGPLIKIATGVLPNLICKALGKC 24 "Brevinin-1TEa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana temporalis (Indian bronzed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria. "Gram-negative bacteria: E. coli (NCLM 2064) (MIC=30 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=150 ?g/ml), V. cholerae (PL 91) (MIC=150 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC=100 ?g/ml), S. aureus (ATCC25923) (MIC>150 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21412958 J Pept Sci. 2011 May;17(5):342-347. "Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S." Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae). DRAMP01886 GIGSMLLGLAKNVGMSLLNKAQCKISGKC 29 "Brevinin-2TEa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana temporalis (Indian bronzed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria. "Gram-negative bacteria: E. coli (NCLM 2064) (MIC=40 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=100 ?g/ml), V. cholerae (PL 91) (MIC=150 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC>150 ?g/ml), S. aureus (ATCC25923) (MIC>150 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21412958 J Pept Sci. 2011 May;17(5):342-347. "Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S." Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae). DRAMP01887 GFMGDTLKGIARNAALALMNAAQCKLSGKC 30 "Brevinin-2TEb (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana temporalis (Indian bronzed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Showes higher antimicrobial activity against Gram-negative than against Gram-positive bacteria. "Gram-negative bacteria: E. coli (NCLM 2064) (MIC=20 ?g/ml), P. aeruginosa (ATCC 10145) (MIC=40 ?g/ml), V. cholerae (PL 91) (MIC=60 ?g/ml);##Gram-positive bacteria: B. cereus (NCLM 2156) (MIC=150 ?g/ml), S. aureus (ATCC25923) (MIC=40 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21412958 J Pept Sci. 2011 May;17(5):342-347. "Reshmy V, Preeji V, Parvin A, Santhoshkumar K, George S." Three novel antimicrobial peptides from the skin of the Indian bronzed frog Hylarana temporalis (Anura: Ranidae). DRAMP01888 FFPTIAGLTKLFCAITKKC 19 "Brevinin-1CHc (Frogs, amphibians, animals)" No entry found Not found Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: E. coli (MIC=80 ?M);##Gram-positive bacterium: S. aureus (MIC=20 ?M).##Yeast: C. albicans (MIC=20 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys13 and Cys19) Disulfide bond between Cys13 and Cys19. L No cytotoxicity information found Not found 21262304 Peptides. 2011 Apr;32(4):664-669. "Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01889 GIGSILGVIAKGLPTLISWIKNR 23 "Brevinin-1TOa (Frogs, amphibians, animals)" No entry found Not found Not found Rana tagoi okiensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: E. coli (MIC=20 ?M);##Gram-positive bacterium: S. aureus (MIC=5 ?M).##Yeast: C. albicans (MIC=20 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19799928 Toxicon. 2010 Feb-Mar;55(2-3):430-435. "Conlon JM, Coquet L, Jouenne T, Leprince J, Vaudry H, Iwamuro S." Evidence from the primary structures of dermal antimicrobial peptides that Rana tagoi okiensis and Rana tagoi tagoi (Ranidae) are not conspecific subspecies. DRAMP01890 FLGAIAGVAAKFLPKVFCFITKKC 24 "Brevinin-1VLa (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Brevinin-1VLa showes particularly high growth-inhibitory potency (MIC < or =3 microM) against a Gram-positive microorganism Staphylococcus aureus and the opportunistic yeast pathogen Candida albicans and potent cytolytic activity (LC(50)< or =8 microM) against both human erythrocytes and HepG2 hepatoma-derived cells. The peptide ia also active against a Gram-negative microorganism Escherichia coli (MIC< or =50 microM). Gram-negative bacterium: E. coli (MIC=25 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=8 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01891 FLPVIASVAAKVLPKVFCFITKKC 24 "Brevinin-1VLc (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Brevinin-1VLc showes particularly high growth-inhibitory potency (MIC < or =3 microM) against a Gram-positive microorganism Staphylococcus aureus and the opportunistic yeast pathogen Candida albicans and potent cytolytic activity (LC(50)< or =8 microM) against both human erythrocytes and HepG2 hepatoma-derived cells. The peptide ia also active against a Gram-negative microorganism Escherichia coli (MIC< or =50 microM). Gram-negative bacterium: E. coli (MIC=50 ?M);##Gram-positive bacterium: S. aureus (MIC=1.5 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=7 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01892 FLPLIAGVAANFLPKIFCLISKKC 24 "Brevinin-1VLd (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells" Gram-negative bacterium: E. coli (MIC>100 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=5 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=6mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01893 FLPLIAGVAASILPKIFCFITKKC 24 "Brevinin-1VLe (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells" Gram-negative bacterium: E. coli (MIC>100 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=5 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=7mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01896 FLSTALKVAANVVPTLFCKITKKC 24 "Brevinin-1CG1 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=9 ?M), Bacillus licheniformis X39 (IS) (MIC=75 ?M);##Gram-negative bacterium: Escherichia coli (ATCC 25922) (MIC=150 ?M).##Fungi: Slime mold 090223 (IS) (MIC=75 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01897 FLPIVAGLAANFLPKIVCKITKKC 24 "Brevinin-1CG2 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=9 ?M), Bacillus licheniformis X39 (IS) (MIC=75 ?M), Enterococcus faecalis 981 (MIC=19 ?M), Staphylococcus carnosus KHS (IS) (MIC=9 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=19 ?M), Serratia rubidaea X01 (IS) (MIC=19 ?M).##Fungi: Slime mold 090223 (IS) (MIC=4.5 ?M), Candida albicans (ATCC 10231) (MIC=150 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01898 FLSTLLNVASNVVPTLICKITKKC 24 "Brevinin-1CG3 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Primarily active against Gram-positive bacteria. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea. "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=2.3 ?M), Bacillus licheniformis X39 (IS) (MIC=9 ?M), Enterococcus faecalis 981 (MIC=75 ?M), Staphylococcus carnosus KHS (IS) (MIC=19 ?M), Staphylococcus aureus (ATCC 25923) (MIC=19 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=4.5 ?M), Serratia rubidaea X01 (IS) (MIC=9 ?M).##Fungi: Slime mold 090223 (IS) (MIC=9 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01899 FLSTLLNVASKVVPTLFCKITKKC 24 "Brevinin-1CG4 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=2.3 ?M), Bacillus licheniformis X39 (IS) (MIC=9 ?M), Enterococcus faecalis 981 (MIC=9 ?M), Staphylococcus carnosus KHS (IS) (MIC=9 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli (ATCC 25922) (MIC=150 ?M), Pseudomonas aeruginosa 11053 (IS) (MIC=75 ?M), Psychrobacter faecalis X29 (IS) (MIC=9 ?M), Serratia rubidaea X01 (IS) (MIC=9 ?M).##Fungi: Slime mold 090223 (IS) (MIC=9 ?M), Candida albicans (ATCC 10231) (MIC=150 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01900 FLPMLAGLAANFLPKIVCKITKKC 24 "Brevinin-1CG5 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Primarily active against Gram-positive bacteria, escecially R. rhodochrous. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea." "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=0.6 ?M), Bacillus licheniformis X39 (IS) (MIC=2.3 ?M), Enterococcus faecalis 981 (MIC=9 ?M), Staphylococcus carnosus KHS (IS) (MIC=1.2 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=75 ?M), Pseudomonas aeruginosa (CGMCC 1.50) (MIC=75 ?M), Pseudomonas aeruginosa 11053 (IS) (MIC=75 ?M), Klebsiella pneumoniae 08040724 (IS) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=9 ?M), Serratia rubidaea X01 (IS) (MIC=4.6 ?M).##Fungi: Slime mold 090223 (IS) (MIC=4.5 ?M), Candida albicans (ATCC 10231) (MIC=437.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01909 GFSSLFKAGAKYLLKSVGKAGAQQLACKAANNCA 34 "Brevinin-2GHa (AMP-1; Frogs, amphibians, animals)" P84860 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana guentheri (Gunther's frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: Problely contains one disulfide bond 27-33. " "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=14.9 ?g/ml), Bacillus subtilis ATCC 6633 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16979798 Peptides. 2006 Dec;27(12):3077-3084. "Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ." Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. DRAMP01910 GVITDALKGAAKTVAAELLRKAHCKLTNSC 30 "Brevinin-2GHb (AMP-2; Frogs, amphibians, animals)" A0AEI5 Belongs to the frog skin active peptide family (Brevinin subfamily) br2GHb Rana guentheri (Gunther's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: Problely contains one disulfide bond 24-30. " "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=16.5 ?g/ml), Bacillus subtilis ATCC 6633 (MIC>64 ?g/ml);##Gram-negative bacteria: Escherichia coli O111 (MIC=8.2 ?g/ml), Escherichia coli ATCC 25922 (MIC=8.2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 16979798 Peptides. 2006 Dec;27(12):3077-3084. "Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ." Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. DRAMP01911 SIWEGIKNAGKGFLVSILDKVRCKVAGGCNP 31 "Brevinin-2GHc (AMP-4; Frogs, amphibians, animals)" A0AEI6 Belongs to the frog skin active peptide family (Brevinin subfamily) br2GHc Rana guentheri (Gunther's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: Problely contains one disulfide bond 24-30. " "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=9.8 ?g/ml), Bacillus subtilis ATCC 6633 (MIC>64 ?g/ml);##Gram-negative bacteria: Escherichia coli O111 (MIC=19.6 ?g/ml), Escherichia coli ATCC 25922 (MIC=9.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 16979798 Peptides. 2006 Dec;27(12):3077-3084. "Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ." Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. DRAMP01913 FLPLLAGLAANFLPKIFCKITKKC 24 "Brevinin-1GRa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. " Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H. " "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami. " DRAMP01914 GLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC 33 "Brevinin-2GRa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M).##Yeast: Candida albicans (MIC>100 ?M). [Ref.16621155] LC50=140 M against human erythrocytes. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16621155##17272268 Peptides. 2006 Sep;27(9):2111-2117.##Mol Cell Proteomics. 2007 May;6(5):882-894. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H.##Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami.##Anti-infection peptidomics of amphibian skin." DRAMP01918 FLPLIAGLAANFLPKIFCAITKKC 24 "Brevinin-1PLb (Frogs, amphibians, animals)" A7WNV3 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity. Tissue specificity: Expressed by the skin glands." Gram-positive bacterium: Staphylococcus aureus (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli(MIC=26 ?M).##Yeast: Candida albicans (MIC=6 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17698247##11087945 Peptides. 2007 Aug;28(8):1605-1610.##Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Zhou M, Wang L, Owens DE, Chen T, Walker B, Shaw C.##Basir YJ, Knoop FC, Dulka J, Conlon JM." "Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step shotgun cloning.##Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01919 FLPVIAGVAAKFLPKIFCAITKKC 24 "Brevinin-1PLc (Frogs, amphibians, animals)" A7WNV4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli(MIC=7 ?M).##Yeast: Candida albicans (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17698247##11087945 Peptides. 2007 Aug;28(8):1605-1610.##Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Zhou M, Wang L, Owens DE, Chen T, Walker B, Shaw C.##Basir YJ, Knoop FC, Dulka J, Conlon JM." "Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step shotgun cloning.##Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01920 FLPILAGLAAKIVPKLFCLATKKC 24 "Brevinin-1CSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Brevinin-1CSa was strongly hemolytic against human erythrocytes. [Ref.17451843]Gram-negative bacterium: Escherichia coli (MIC=32 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M). [Ref.17451843] LD50=5 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 17451843 Peptides. 2007 Jun;28(6):1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP18383 DEDLDE 6 "XLAsp-P2 (X. laevis antibacterial peptide-P2; frog, amphibians, animals)" No entry found Not found Not found "skin, African clawed frog, Xenopus laevis, Africa" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 28299865 J Pept Sci. 2017 Mar 16. in press. doi: 10.1002/psc. "Zhang Y, Liu S, Li S, Cheng Y, Nie L, Wang G, Lv C, Wei W, Cheng C, Hou F, Hao L" Novel short antimicrobial peptide isolated from Xenopus laevis skin DRAMP01922 GLFNVFKKVGKNVLKNVAGSLMDNLKCKVSGEC 33 "Brevinin-2SKb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sakuraii (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17174009 Peptides. 2007 Mar;28(3):505-514. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii. DRAMP01933 GIMDTLKNLAKTAGKGALQSLVKMASCKLSGQC 33 "Brevinin-2Ef (Frogs, amphibians, animals)" P40842 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity " [Swiss_Prot Entry P40842]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species [Ref.8163497]LC50>100 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8163497 J Biol Chem. 1994 Apr 22;269(16):11956-11961. "Simmaco M, Mignogna G, Barra D, Bossa F." Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. DRAMP01934 GILSTIKDFAIKAGKGAAKGLLEMASCKLSGQC 33 "Brevinin-2Ei (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01935 GIFLDKLKNFAKGVAQSLLNKASCKLSGQC 30 "Brevinin-2Ej (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli (MIC=2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01937 GLGSILGKILNVAGKVGKTIGKVADAVGNKE 31 "CPRF-Ea (caerulein precursor-related fragment; Frogs, amphibians, animals)" No entry found Not found Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli (MIC=4 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01938 GLGSFLKNAIKIAGKVGSTIGKVADAIGNKE 31 "CPRF-Eb (caerulein precursor-related fragment; Frogs, amphibians, animals)" No entry found Not found Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli (MIC=5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01939 GLGSFFKNAIKIAGKVGSTIGKVADAIGNKE 31 "CPRF-Ec (caerulein precursor-related fragment; Frogs, amphibians, animals)" No entry found Not found Not found Rana esculenta complex "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None "Function: Potently and selectively inhibits the growth of the Gram-positive bacterium Escherichia coli. No peptide, at concentrations up to 100 ?M, inhibited the growth of the fungal pathogen C. albicans. Sequence similarity: This peptide shows limited amino acid sequence similarity to the homologous exon gene products that encode the N-terminal flanking peptides of preprocaerulein, preproxenopsin, and preprolevitide." Gram-negative bacterium: Escherichia coli (MIC=4 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499272 Peptides. 2003 Jul;24(7):955-961. "Ali MF, Knoop FC, Vaudry H, Conlon JM." Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. DRAMP01940 FLPIIAGVAAKVLPKLFCAITKKC 24 "Brevinin-1CHa (Frogs, amphibians, animals)" A7YJE2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None PTM: Contains disulfide bond. "Gram-negative bacteria: E. coli (MIC=10 ?M), K. pneumoniae (MIC=40 ?M), P. aeruginosa (MIC=20 ?M);##Gram-positive bacterium: S. aureus (MIC=2.5 ?M).##Yeast: C. albicans (MIC=2.5 ?M).(Ref.2)" [Ref.21262304] LC50=5 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 17938991##21262304 J Mol Evol. 2007 Nov;65(5):605-615.##Peptides. 2011 Apr;32(4):664-669. "Tennessen JA, Blouin MS.##Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.##Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01941 FLPVIAGLAAKVLPKLFCAITKKC 24 "Brevinin-1CHb (Frogs, amphibians, animals)" A7YJE4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None PTM: Contains disulfide bond. "Gram-negative bacteria: E. coli (MIC=10 ?M), K. pneumoniae (MIC=40 ?M), P. aeruginosa (MIC=10 ?M);##Gram-positive bacterium: S. aureus (MIC=2.5 ?M).##Yeast: C. albicans (MIC=2.5 ?M).(Ref.2)" [Ref.21262304] LC50=5 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 17938991##21262304 J Mol Evol. 2007 Nov;65(5):605-615.##Peptides. 2011 Apr;32(4):664-669. "Tennessen JA, Blouin MS.##Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.##Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01942 FLPAIVGAAGQFLPKIFCAISKKC 24 "Brevinin-1Sa (Frogs, amphibians, animals)" P82904 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sphenocephala (Southern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=55 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10604597 J Pept Res. 1999 Dec;54(6):522-527. "Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC." "Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala." DRAMP01943 FLPAIVGAAGKFLPKIFCAISKKC 24 "Brevinin-1Sb (Frogs, amphibians, animals)" P82905 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sphenocephala (Southern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=17 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10604597 J Pept Res. 1999 Dec;54(6):522-527. "Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC." "Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala." DRAMP01944 FFPIVAGVAGQVLKKIYCTISKKC 24 "Brevinin-1Sc (Frogs, amphibians, animals)" P82906 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sphenocephala (Southern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=14 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10604597 J Pept Res. 1999 Dec;54(6):522-527. "Conlon JM, Halverson T, Dulka J, Platz JE, Knoop FC." "Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala." DRAMP01949 FLPAVLRVAAKIVPTVFCAISKKC 24 "Brevinin-1HSa (Frogs, amphibians, animals)" P0C8S7 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana hosii (Hose's rock frog) (Odorrana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 18-24." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=24 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01950 FLPAVLRVAAQVVPTVFCAISKKC 24 "Brevinin-1HSb (Brevinin-1JDb; Frogs, amphibians, animals)" P0C8S8 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana hosii (Hose's rock frog) (Odorrana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 18-24." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC>48 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01951 FMGGLIKAATKIVPAAYCAITKKC 24 "Brevinin-1PTa (Frogs, amphibians, animals)" P0C8T1 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 18-24." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=24 ?M). Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01953 GLLDSLKNLAINAAKGAGQSVLNTLSCKLSKTC 33 "Brevinin-2HSa (Frogs, amphibians, animals)" P0C8S9 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hosii (Hose's rock frog) (Rana hosii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=36 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01955 GAIKDALKGAAKTVAVELLKKAQCKLEKTC 30 "Brevinin-2PTa (Frogs, amphibians, animals)" P0C8T3 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 24-30." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01956 GFKGAFKNVMFGIAKSAGKSALNALACKIDKSC 33 "Brevinin-2PTb (Frogs, amphibians, animals)" P0C8T4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=9 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01957 GLLDSFKNAMIGIAKSAGKTALNKIACKIDKTC 33 "Brevinin-2PTc (Frogs, amphibians, animals)" P0C8T5 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>72 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01959 GFLDSFKNAMIGVAKSVGKTALSTLACKIDKSC 33 "Brevinin-2PTe (Frogs, amphibians, animals)" P0C8T7 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana picturata (Malaysian fire frog) (Hylarana picturata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=36 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=18 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18621071 Toxicon. 2008 Sep 1;52(3):465-473. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD." "Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)." DRAMP01963 FLPAIVGAAAKFLPKIFCAISKKC 24 "Brevinin-1BLa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates blairi (plains leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus" [Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=1.5 M);##Gram-negative bacteria : Escherichia coli(MIC=25 M);##Fungi : Candida albicans(MIC=6 M) [Ref.19254736] LC50=14 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01965 FLPIIAGIAAKFLPKIFCTISKKC 24 "Brevinin-1BLc (Frogs, amphibians, animals)" B6CPR0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates blairi (leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans [Ref.19254736]Gram-negative bacterium:?Escherichia coli (MIC=25 ?M);##Gram-positive bacterium:?Staphylococcus aureus (MIC=1.5 ?M);##Yeast:?Candida albicans (MIC=3 ?M);##Cancer cells HepG2:?(LC50=6 ?M).. [Ref.19254736] LC50=9 M against human red blood cells.##[Ref.14531844]Non-hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01968 FLPIIAGAAAKVVEKIFCAISKKC 24 "Brevinin-1Yc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates yavapaiensis (North American leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans [Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=6 M);##Gram-negative bacteria : Escherichia coli(MIC=100 M);##Fungi : Candida albicans(MIC=6 M)Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).##Yeast: Candida albicans (MIC=6 ?M).##cancer cells HepG2 (LC50=14 ?M). [Ref.19254736] LC50=13 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01969 FLGSLIGAAIPAIKQLLGLKK 21 "Brevinin-1Ja (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana japonica (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None It can produced cell death of mammalian COS7 cells (LD50=28 ?M). Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=119 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18558801 Zoolog Sci 2008; 25: 487-491. "Koyama T, Iwamuro S." "Molecular cloning of a cDNA encoding atypical antimicrobial and cytotoxic brevinin-1Ja from the skin of the Japanese brown frog, Rana japonica." DRAMP01970 FLPFLLSALPKVFCFFSKKC 20 "Brevinin-1ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=32 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>43 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01971 FLPLLLSALPSFLCLVFKKC 20 "Brevinin-1ZHb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=33 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC>44 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>44 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01974 GIMRVFKGVLKTAGKSVAKNVAGSFLDRLKCKISGGC 37 "Brevinin-2ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=5 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01986 SLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC 33 "Brevinin-2HS2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Huia schmackeri (Chinese piebald odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: It shows poor hemolycity activity (LC50=300 uM). "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 ?M), Bacillus licheniformis X39 (MIC=39 ?M), Rhodococcus rhodochrous X15 (MIC=9.5 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 ?M).##Fungi: Slime mould 090223 (MIC=37.5 ?M), Candida albicans ATCC2002 (MIC=19 ?M)." LC50=300?M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18423796 Peptides. 2008 Aug;29(8):1456-1460. "Quan Z, Zhou M, Chen W, Chen T, Walker B, Shaw C." Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors. DRAMP01990 FMGSALRIAAKVLPAALCQIFKKC 24 "Brevinin-1LT1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii (Chinese broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity against rabbit red blood cells." "[Ref.19340924]Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 ?M), Bacillus subtilis (MIC=6.25 ?M);##Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 ?M);##Yeast: Candida albicans (MIC=50 ?M)." [Ref.19340924]LC50>200 ?g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19340924 Biochimie. 2009 Apr;91(4):540-547. "Wang H, Yan X, Yu H, Hu Y, Yu Z, Zheng H, Chen Z, Zhang Z, Liu J." "Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae)." DRAMP01994 SLLDTFKNLAVNAAKSAGVSVLNALSCKISRTC 33 "Brevinin-2ISa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. "Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 ?M), S. aureus (MRSA) (MIC=100 ?M), Bacillus subtilis (MIC=12.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01995 SFLTTFKDLAIKAAKSAGQSVLSTLSCKLSNTC 33 "Brevinin-2ISb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), Bacillus subtilis (MIC=25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01996 SVLGTVKDLLIGAGKSAAQSVLTTLSCKLSNSC 33 "Brevinin-2ISc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP02001 FLPLIASLAANFVPKIFCKITKKC 24 "Brevinin-1HN1 (Frogs, amphibians, animals)" E7EKC4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P. faecalis. Has hemolytic activity against human erythrocytes (LC50=75 ?M). Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond." "[Ref.22450466]Gram-positive bacteria: Enterococcus faecium 091299 (MIC=19 ?M), Enterococcus faecalis 981 (MIC=19 ?M), Staphylococcus aureus ATCC2592 (MIC=1.2 ?M), Staphylococcus carnosus KHS (MIC=4.8 ?M), Bacillus licheniformis X39 (MIC=2.4 ?M), Rhodococcus rhodochrous X15 (MIC=1.2 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=150 ?M), Psychrobacter faecalis X29 (MIC=4.8 ?M);##Fungi: Slime mould 090223 (MIC=1.2 ?M), Candida albicans ATCC2002 (MIC=2.4 ?M)." [Ref.22450466] LC50=75 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP02004 FLPLIASVAANLVPKIFCKITKKC 24 "Brevinin-1V (Frogs, amphibians, animals)" "Q2UXV8, E7EKC5" Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana versabilis (Chinese bamboo leaf odorous frog) (Rana versabilis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P. faecalis. Has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond." "[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 ?M), Bacillus licheniformis X39 (MIC=37.5 ?M), Rhodococcus rhodochrous X15 (MIC=9.5 ?M), Enterococcus faecium 091299 (MIC=19 ?M), E. faecalis 981 (MIC=19 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 ?M);##Fungi: Slime mould 090223 (MIC=1.2 ?M), Candida albicans ATCC2002 (MIC=19-37.5 ?M)." [Ref.22450466] LC50=75 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 16139929##22450466 Peptides. 2006 Jan;27(1):42-48.##Peptides. 2012 Jun;35(2):285-290. "Chen T, Li L, Zhou M, Rao P, Walker B, Shaw C.##Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Amphibian skin peptides and their corresponding cDNAs from single lyophilized secretion samples: identification of novel brevinins from three species of Chinese frogs.##Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP02006 GIWDTLKNVGKAVLGKVLENV 21 "Brevinin-2Va (Frogs, amphibians, animals)" No entry found Not found Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=12 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15996769 Regul Pept. 2005 Nov;131(1-3):38-45. "Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR." "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP02009 FLPVLAGIAAKVVPALFCKITKKC 24 "Brevinin-1 (Frogs, amphibians, animals)" P32423 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana brevipoda porsa (Japanese frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity." [Ref.1449472]Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=34 ?g/ml). [Ref.1449472] high hemolytic activity Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 1449472 Biochem Biophys Res Commun. 1992 Nov 30;189(1):184-190. "Morikawa N, Hagiwara K, Nakajima T." "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa." DRAMP02010 GLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC 33 "Brevinin-2 (Frogs, amphibians, animals)" P32424 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana brevipoda porsa (Japanese frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity." [Ref.1449472]Gram-positive bacterium: Staphylococcus aureus (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=4 ?g/ml). [Ref.1449472] high hemolytic activity Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 1449472 Biochem Biophys Res Commun. 1992 Nov 30;189(1):184-190. "Morikawa N, Hagiwara K, Nakajima T." "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa." DRAMP02019 GLFDVVKGVLKGAGKNVAGSLLEQLKCKLSGGC 33 "Brevinin-2DYb (Frogs, amphibians, animals)" P0C5X2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus (MIC=30 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 17688900 Toxicon. 2007 Nov;50(6):746-756. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S." "Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii." DRAMP18381 VVYALKRNGRTLYGF 15 H4-(86-100) (histone-derived) No entry found Not found Not found rat "Antimicrobial, Antibacterial" Not found Not found None "Fuction: ATP can enahnce its activity, implying its involvement in inhibiting the DNA gyrase activity." "Active against E. coli (LD90 6.68 ug/ml), P. aeruginosa (LD90 4.8 ug/ml), B. subtilis (LD90 17 ug/ml), and S. aureus (14.7 ug.ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18803668 FEBS J. 2008 Nov;275(21):5286-97. "Lemaire S, Trinh TT, Le HT, Tang SC, Hincke M, Wellman-Labadie O, Ziai S." "Antimicrobial effects of H4-(86-100), histogranin and related compounds--possible involvement of DNA gyrase." DRAMP18382 VVYTLKRNGRTLYGF 15 HNr (histone-derived) No entry found Not found Not found rat "Antimicrobial, Antibacterial" Not found Not found None "Fuction: ATP can enahnce its activity, implying its involvement in inhibiting the DNA gyrase activity." "Active against E. coli (LD90 10.3 ug/ml), P. aeruginosa LD90 8.7 ug/ml), and B. subtilis (LD90 14 ug/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18803668 FEBS J. 2008 Nov;275(21):5286-97. "Lemaire S, Trinh TT, Le HT, Tang SC, Hincke M, Wellman-Labadie O, Ziai S." "Antimicrobial effects of H4-(86-100), histogranin and related compounds--possible involvement of DNA gyrase." DRAMP02023 GIFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC 33 "Brevinin-2DYd (Frogs, amphibians, animals)" P0C5X4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 27-33." Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15 ?M).##NOTE: mixture of Brevinin-2DYc/2DYd No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 17688900 Toxicon. 2007 Nov;50(6):746-756. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S." "Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii." DRAMP18380 SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAQRVGAGAPVY 50 Acipensin 1 (Ac1) No entry found Not found Not found "Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii" "Antimicrobial, Antibacterial, Antifungal" Not found Not found None Comment: No comments found on DRAMP database "Active against E. coli ML35p (MIC 0.7 uM), L. monocytogenes EGD (MIC 1.1 uM), MRSA ATCC 33591 (MIC 0.9 uM), C. albicans 820 (MIC 1 uM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 25558400 Acta Naturae. 2014 Oct;6(4):99-109 "Shamova OV, Orlov DS, Balandin SV, Shramova EI, Tsvetkova EV, Panteleev PV, Leonova YF, Tagaev AA, Kokryakov VN, Ovchinnikova TV." Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii DRAMP02025 GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKISGGC 37 "Brevinin-2DYe (Brevinin-2CDYa; Frogs, amphibians, animals)" P0C5X5 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Active against the Gram-positive bacteria: S. aureus and Gram-negative bacteria E. coli. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 31-37. Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 17688900##17698251 Toxicon. 2007 Nov;50(6):746-756.##Peptides. 2007 Aug;28(8):1532-1539. "Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S.##Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." "Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii.##Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii." DRAMP02026 LLSLALAALPKLFCLIFKKC 20 "Brevinin-1CDYa (Frogs, amphibians, animals)" B3VZU0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dybowskii (Dybovsky's frog) (Korean brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has low activity against the Gram-positive bacteria: S. aureus and Gram-negative bacteria E. coli. Has hemolytic activity against human erythrocytes (HC50=125 ?M). Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 14-20." [Swiss_Prot Entry B3VZU0]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25 ?M) [Ref.19539775]HC50=125 M against human red blood cells Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 19539775 Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178. "Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH." "Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii." DRAMP18379 SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLR 35 Acipensin 2 (Ac2) No entry found Not found Not found "Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii" "Antimicrobial, Antibacterial, Antifungal" Not found Not found None Comment: No comments found on DRAMP database "Active against E. coli ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), C. albicans 820 (MIC 0.9 uM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 25558400 Acta Naturae. 2014 Oct;6(4):99-109. "Shamova OV, Orlov DS, Balandin SV, Shramova EI, Tsvetkova EV, Panteleev PV, Leonova YF, Tagaev AA, Kokryakov VN, Ovchinnikova TV." Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii. DRAMP02031 ILPLLLGKVVCAITKKC 17 "Brevinin-1Da (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana dalmatina (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Sequence alignment suggests that the peptide is derived from brevinin-1 by multiple residue deletions (D for ""dalmatina"" and 'a' to denote the first isoform identified). " Gram-positive bacterium: Staphylococcus aureus (MIC=7 ?M);##Gram-negative bacterium: Escherichia coli (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys11 and Cys17) Disulfide bond between Cys11 and Cys17. L No cytotoxicity information found Not found 15050930 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Feb;137(2):191-196. "Conlon JM, Seidel B, Nielsen PF." An atypical member of the brevinin-1 family of antimicrobial peptides isolated from the skin of the European frog Rana dalmatina. DRAMP02032 FLGSIVGALASALPSLISKIRN 22 "Brevinin-1TSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tsushimensis (Tsushima brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, but hemolytic activity against human erythrocytes." "[Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Klebsiella pneumoniae KK3 9904 (MIC>100 ?M), Enterobacter cloacae HNTCC 53001 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=50 ?M), Proteus mirabilis ATCC 25933 (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=25 ?M), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 ?M), Staphylococcus epidermidis RP62A (MIC=12.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=50 ?M), Streptococcus group B HNTCC 80130 (MIC=50 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=50 ?M)" [Ref.16413829]LD50=12 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16413829 Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. "Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. DRAMP02033 GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC 33 "Brevinin-2TSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tsushimensis (Tsushima brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, but relatively low hemolytic activity against human erythrocytes." "[Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Klebsiella pneumoniae KK3 9904 (MIC=6 ?M), Enterobacter cloacae HNTCC 53001 (MIC=6 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=6 ?M), Proteus mirabilis ATCC 25933 (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=12.5 ?M), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 ?M), Staphylococcus epidermidis RP62A (MIC=12.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=25 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=100 ?M)." [Ref.16413829] LD50=100 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16413829 Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. "Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. DRAMP02034 FLPILAGLAAKLVPKVFCSITKKC 24 "Brevinin-1AUa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana aurora aurora (Northern red-legged frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and also shows hemolytic. " "[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=13 ?M), Pseudomonas aeruginosa (MIC=25 ?M), Enterobacter cloacae (MIC=13 ?M), Klebsiella pneumoniae (MIC=50 ?M), Proteus mirabilis (MIC>50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Staphylococcus epidermidis (MIC=6 ?M), Enterococcus faecalis (MIC=13 ?M), Streptococcus Group B (MIC=13 ?M);##Yeast: Candida albicans (MIC>40 ?M)." [Ref.15325526] HC50=5 M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 15325526 Dev Comp Immunol. 2005;29(1):83-90. "Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T." Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. DRAMP02035 FLPILAGLAANILPKVFCSITKKC 24 "Brevinin-1AUb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana aurora aurora (Northern red-legged frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and also shows hemolytic activity. " "[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=25 ?M), Pseudomonas aeruginosa (MIC=25 ?M), Enterobacter cloacae (MIC=25 ?M), Klebsiella pneumoniae (MIC>50 ?M), Proteus mirabilis (MIC>50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Staphylococcus epidermidis (MIC=6 ?M), Enterococcus faecalis (MIC=6 ?M), Streptococcus Group B (MIC=13 ?M);##Yeast: Candida albicans (MIC=3 ?M)." [Ref.15325526] HC50=7 M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 15325526 Dev Comp Immunol. 2005;29(1):83-90. "Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T." Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. DRAMP02036 GAFGNFLKGVAKKAGLKILSIAQCKLSGTC 30 "Brevinin-2-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Brevinin-2-RN1 and -RN2 could induce 17 and 21% Rabbit red blood cell hemolysis, respectively." "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.10 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=3.10 ?g/ml), Bacillus subtilis (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=6.25 ?g/ml)." [Ref.21171145] It has 17% hemolysis at 100 ?g/ml against rabbit red blood cell Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 21171145 J Pept Sci. 2011 Jan;17(1):68-72. "Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R." "Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata." DRAMP02037 GAFGNFLKGVAKKAGLKILSIAQCKLFGTC 30 "Brevinin-2-RN2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Brevinin-2-RN1 and -RN2 could induce 17 and 21% Rabbit red blood cell hemolysis, respectively." "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=6.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 ?g/ml), Bacillus subtilis (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=50 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=12.5 ?g/ml). Yeast: Candida albicans ATCC2002 (MIC=3.1 ?g/m)." [Ref.21171145] It has 21% hemolysis at 100 ?g/ml against rabbit red blood cell Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 21171145 J Pept Sci. 2011 Jan;17(1):68-72. "Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R." "Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata." DRAMP02038 VIVFVASVAAEMMQHVYCAASKKC 24 "Brevinin-1-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 ?g/ml);##Gram-negative bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml), Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml).##Yeast: Candida albicans (MIC=24.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP18378 ILELAGNAARDNKKTRIIPRHLQL 24 Acipensin 6 (Ac6) No entry found Not found Not found "Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against E. coli ML35p (MIC 2.5 uM). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 25558400 Acta Naturae. 2014 Oct;6(4):99-109. "Shamova OV, Orlov DS, Balandin SV, Shramova EI, Tsvetkova EV, Panteleev PV, Leonova YF, Tagaev AA, Kokryakov VN, Ovchinnikova TV." Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii DRAMP02040 FLPAVIRVAANVLPTAFCAISKKC 24 "Brevinin-1-OA12 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.2 ?g/ml).##Yeast: Candida albicans (MIC=3.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02041 LPFVAGVAAEMMQHVYCAASKKC 23 "Brevinin-1-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=42.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.6 ?g/ml).##Yeast: Candida albicans (MIC=10.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys17 and Cys23) Disulfide bond between Cys17 and Cys23. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02042 IDPFVAGVAAEMMQHVYCAASKKC 24 "Brevinin-1-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=9.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=18.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18.2 ?g/ml).##Yeast: Candida albicans (MIC=18.2 ?g/ml). " [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02043 INPFVAGVAAEMMQHVYCAASKKC 24 "Brevinin-1-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml).##Yeast: Candida albicans (MIC=8.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02044 ILPFVAGVAAEMMKHVYCAASKKC 24 "Brevinin-1-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None It differs from AP1824 only at position 14: Q vs. K. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.2 ?g/ml).##Yeast: Candida albicans (MIC=7.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02045 IIPFVAGVAAEMMEHVYCAASKKC 24 "Brevinin-1-OR6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None It differs from AP1827 at two positions: 2: I vs. L and 14: K vs. E. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.2 ?g/ml).##Yeast: Candida albicans (MIC=11.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02046 QLPFVAGVACEMCQCVYCAASKKC 24 "Brevinin-1-OR7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=5.7 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.4 ?g/ml).##Yeast: Candida albicans (MIC=11.4 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02047 ILPFVAGVAAEMMEHVYCAASKKC 24 "Brevinin-1-OR8 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=52.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=26.2 ?g/ml).##Yeast: Candida albicans (MIC=13.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02048 ILPFVAGVAAMEMEHVYCAASKKC 24 "Brevinin-1-OR9 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=9.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=9.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.9 ?g/ml).##Yeast: Candida albicans (MIC=9.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02049 FLPAVLLVATHVLPTVFCAITRKC 24 "Brevinin-1-OR10 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=27.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.8 ?g/ml).##Yeast: Candida albicans (MIC=6.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02050 LAFVAGVAAEMMQHVYCAASKKC 23 "Brevinin-1-OR11 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 ?g/ml).##Yeast: Candida albicans (MIC=12.4 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys17 and Cys23) Disulfide bond between Cys17 and Cys23. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02051 ILPFVAGVAAEMMQHVYCAASKKC 24 "Lividin-1 (Brevinin-1-OR2; Frogs, amphibians, animals)" Q2UXR4 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-1 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 ?g/ml).##Yeast: Candida albicans (MIC=5.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02052 SFLDTLKNLAISAAKGAGQSVLSTLSCKLSKTC 33 "Lividin-2 (Brevinin-2-OR8; Frogs, amphibians, animals)" Q2UXR3 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-2 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=13.1 ?g/ml).##Yeast: Candida albicans (MIC=13.1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02053 SVLGTVKDLLIGAGKSAAQSVLTALSCKLSNSC 33 "Lividin-3 (Brevinin-2-OR1; Frogs, amphibians, animals)" Q2UXR2 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-3 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11 ?g/ml).##Yeast: Candida albicans (MIC=11 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02054 GILDTFKNMALNAAKSAGVSVLNALSCKLSKTC 33 "Brevinin-2-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.1 ?g/ml).##Yeast: Candida albicans (MIC=6.0 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02055 GLLDTFKNMALNAAKSAGVSVLNALSCKLSKTC 33 "Brevinin-2-OA2 (Brevinin-2E-OG1; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Found in multiple species. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml).##Yeast: Candida albicans (MIC=6.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02056 GLLDTFKNMAINAAHGAGVSVLNALSCKLKKTC 33 "Brevinin-2-OA3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml).##Yeast: Candida albicans (MIC=3.2 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02057 GLLDTFKNLAINAAESAGVSVLNSLSCKLSKTC 33 "Brevinin-2-OA4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=10 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02058 GLLDGILNANFNAAKSAGTSVLNALSCKLSKTC 33 "Brevinin-2-OA5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=30.6 ?g/ml).##Yeast: Candida albicans (MIC=30.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02059 GVLATVKNLLIGTGDGAAQSVLKTLSCKLSNDC 33 "Brevinin-2-OA6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=44.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.4 ?g/ml).##Yeast: Candida albicans (MIC=11.2 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02060 GVLGTVKDLLIGAGKSAAQSTLKTLSCKISNDC 33 "Brevinin-2-OA7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 ?g/ml).##Yeast: Candida albicans (MIC=5.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02061 GVLATVKNLLNGTGDGAAQSVLKTLSCKLSNDC 33 "Brevinin-2-OA8 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.9 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.0 ?g/ml).##Yeast: Candida albicans (MIC=4.0 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02062 GLLDTIKNMALNAAKSAGVSVLNSLSCKLSKTC 33 "Brevinin-2-OR2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.0 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.1 ?g/ml).##Yeast: Candida albicans (MIC=12.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02063 GLIDTIKNMALNAAKSAGVSVLNTLSCKLSKTC 33 "Brevinin-2-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=41.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.6 ?g/ml).##Yeast: Candida albicans (MIC=10.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02064 SVLGTVKDLLIGAGKSAAQSVLTANSCKLSNSC 33 "Brevinin-2-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.9 ?g/ml).##Yeast: Candida albicans (MIC=11.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02065 SFLDTLKNLAISAAKGAGQSVLSTLSCKLSETC 33 "Brevinin-2-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml).##Fungi: Candida albicans (MIC=6.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02066 GLLDTIKNMALNAAKSAGVSVLNSLSCKDSKTC 33 "Brevinin-2-OR6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.8 ?g/ml).##Fungi: Candida albicans (MIC=11.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02067 GLLDTIKNMALNAAKSAGVSVLNTLSCKLSKTC 33 "Brevinin-2-OR7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml).##Fungi: Candida albicans (MIC=17.2 ?g/ml)" [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02068 SFLSTFKELAINAAKNAGQSILHTLSCKLDKTC 33 "Brevinin-2-OR9 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10.2 ?g/ml).##Fungi: Candida albicans (MIC=5.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02069 SFLSTFKELAINAAKNAGQSLLHTLSCKLDKTC 33 "Brevinin-2-OR10 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: It differs from AP1850 only at position 21: L vs. I, so they are predicted to have essentially identical structure and activity." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=7.9 ?g/ml).##Fungi: Candida albicans (MIC=15.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02070 SVMGTVKDLLIGAGKSAAQSVLKSLSCKISNDC 33 "Brevinin-2-OW1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.7 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=9.4 ?g/ml).##Fungi: Candida albicans (MIC=4.7 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02071 SVMGTVKDLLIGAGKSAAQSVLKSLSCKLSNDC 33 "Brevinin-2-OW2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.3 ?g/ml).##Fungi: Candida albicans (MIC=3.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02072 SVMGTVKDLLIGAGKSAAQSVLKALSCKLSKDC 33 "Brevinin-2-OW3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.0 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.5 ?g/ml).##Fungi: Candida albicans (MIC=10.5 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02073 FLPAVIRVAANVLPTVFCAISKKC 24 "Brevinin-1JDa (Frogs, amphibians, animals)" B3A0M4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bonds." "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), S. aureus (MRSA) (MIC=32 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=128 ?g/ml);##Fungi: Candida albicans (MIC=128 ?g/ml)." [Ref.22917879] It has 79.2 6.8% hemolytic activity at 128 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP02075 FLPAVLRVAAKVVPTVFCLISKKC 24 "Brevinin-1JDc (Frogs, amphibians, animals)" B3A0N0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bonds." "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), S. aureus (MRSA) (MIC=8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=128 ?g/ml)." [Ref.22917879] It has 11.7 3.2% hemolytic activity at 64 g/mL and 88.4 4.2% hemolytic activity at 128 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP18376 GGGGGGHLVA 10 "Peptide fraction II (Gly-rich; insects, arthropods, invertebrates, animals)" No entry found Not found Not found "Hemolymph, Antheraea mylitta" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database Active against E. coli and P. aeruginosa. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 28302399 Bioorg Med Chem Lett. 2017 Mar 3. in press. "Dutta SR, Gauri SS, Ghosh T, Halder SK, DasMohapatra PK, Mondal KC, Ghosh AK." Elucidation of structural and functional integration of a novel antimicrobial peptide from Antheraea mylitta. DRAMP18377 MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLK 38 "Sphistin (histone-derived, Crustaceans, arthropods, invertebrates, animals)" No entry found Not found Not found "haemolymphs, Scylla paramamosain" "Antimicrobial, Antibacterial" Not found Not found None Comment: No comments found on DRAMP database "Active against G+ bacteria (S. aureus, C. glutamicum, B. subtilis, M. lysodeikticus, M. luteus) and G- bacteria (S. flexneri, P. stutzeri, and P. fluorescens) (MIC < 1.5 uM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 25558400 Fish Shellfish Immunol. 2015 Dec;47(2):833-46. "Chen B, Fan DQ, Zhu KX, Shan ZG, Chen FY, Hou L, Cai L, Wang KJ." Mechanism study on a new antimicrobial peptide Sphistin derived from the N-terminus of crab histone H2A identified in haemolymphs of Scylla paramamosain. DRAMP01745 LLPNLLKSLL 10 "Temporin-K (Frogs, amphibians, animals)" P56923 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None Function: Antibacterial activity against Gram-positive bacteria. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9022710 Eur J Biochem. 1996 Dec 15;242(3):788-792. "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D." "Temporins, antimicrobial peptides from the European red frog Rana temporaria." DRAMP01746 FVQWFSKFLGRIL 13 "Temporin-L (Temporin-1Tl; temporin-Tl; TL; Frogs, amphibians, animals)" P57104 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic, Anti-cancer" Protein level Alpha helix Not found 6GS5 resolved by NMR. "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. PTM: Leucine amide at position 13. Tissue specificity: Expressed by the skin glands." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9022710 Eur J Biochem. 1996 Dec 15;242(3):788-792. "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D." "Temporins, antimicrobial peptides from the European red frog Rana temporaria." DRAMP02078 FLPVVAGLAAKVLPSIICAVTKKC 24 "Brevinin-1SY (Frogs, amphibians, animals)" P82871 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sylvatica (Wood frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=7 ?M);##Gram-negative bacterium: Escherichia coli (MIC=45 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11042268 FEBS Lett. 2000 Oct 20;483(2-3):135-138. "Matutte B, Storey KB, Knoop FC, Conlon JM." "Induction: of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli." DRAMP04238 FFHLHFHY 8 PL-101 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Synthetic Not found Not found None Function: Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. "[Ref.12569105] Gram-negative bacterium: Escherichia coli (MEC=7 g/ml), Pseudomonas aeruginosa (MEC=10 g/ml).;##Gram-positive bacteria: Staphylococcus aureus (MEC=3 g/ml), MRSA (MEC=4 g/ml) at PH 6.5." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12569105 J Biol Chem. 2003 Apr 11;278(15):13546-53. "Tincu JA, Menzel LP, Azimov R, Sands J, Hong T, Waring AJ, Taylor SW, Lehrer RI." "Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes." DRAMP02778 AHCLAIGRK 9 "Defensin (Insects, animals)" O96049 Belongs to the invertebrate defensin family (Type 1 subfamil Not found Oryctes rhinoceros (Coconut rhinoceros beetle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None Function: Shows very strong activity against Staphylococcus aureus. Has no hemolytic activity. "[Ref.10561605] Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus aureus (MRSA) (MIC>50 ?g/ml);## Gram-negative bacteria: Escherichia coli (MIC=25 ?g/ml), Pseudomonas aeruginosa (MIC>50 ?g/ml)." [Ref.10561605] Had no hemolytic activity against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10561605 Eur. J. Biochem. 1999;266:616-623. "Ishibashi J, Yang J, Saido-Sakanaka H, Nakazawa H, Yamamoto M, Yamakawa M." "Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros." DRAMP02084 GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC 33 "Brevinin-2E (Frogs, amphibians, animals)" P32413 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity." "[Ref.8508915]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=2.0 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa ATCC 15692 (MIC>30 ?M)." [Ref.8163497]LC50>100 M against human red blood cells Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 8508915 FEBS Lett. 1993 Jun 14;324(2):159-161. "Simmaco M, Mignogna G, Barra D, Bossa F." Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. DRAMP02101 FLPLLAGVVANFLPQIICKIARKC 24 "Brevinin-1RTa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells (LD50=100.0 ?g/ml) in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=6.3 ?g/ml), Bacillus licheniformis X39 (MIC=25.0 ?g/ml), Rhodococcus rhodochrous X15 (MIC=3.1 ?g/ml);##Gram-negative bacteria: Serratia rubidaea X01 (MIC=NA ?g/ml), Pseudomonas aeruginosa 1.50 (MIC=NA ?g/ml), Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)." [Ref.22100518]LD50=100 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02102 FLGSLLGLVGKVVPTLFCKISKKC 24 "Brevinin-1RTb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells (LD50=200.0 ?g/ml) in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.1 ?g/ml), Bacillus licheniformis X39 (MIC=25.0 ?g/ml), Staphylococcus carnosus KHS (MIC=12.5 ?g/ml), Rhodococcus rhodochrous X15 (MIC=3.1 ?g/ml);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)" [Ref.22100518]LD50=200 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02104 GLMSTLKDFGKTAAKEIAQSLLSTASCKLAKTC 33 "Brevinin-2RTa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=12.5 ?g/ml), Bacillus licheniformis X39 (MIC=50.0 ?g/ml), Staphylococcus carnosus KHS (MIC=6.3 ?g/ml), Rhodococcus rhodochrous X15 (MIC=1.6 ?g/ml);##Gram-negative bacteria: Serratia rubidaea X01 (MIC=100.0 ?g/ml), Psychrobacter faecalis X29 (MIC=6.3 ?g/ml)." [Ref.22100518]LD50>400 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02105 GILDTLKEFGKTAAKGIAQSLLSTASCKLAKTC 33 "Brevinin-2RTb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and relatively low hemolytic activity (>400 ?g/ml) against rabbit red blood cells in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=50.0 ?g/ml), Bacillus licheniformis X39 (MIC=200.0 ?g/ml), Staphylococcus carnosus KHS (MIC=100.0 ?g/ml), Rhodococcus rhodochrous X15 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=12.5 ?g/ml)." [Ref.22100518]LD50>400 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02114 AWLDKLKSLGKVVGKVALGVAQNYLNPQQ 29 "Raniseptin-1 (Rsp-1; Frogs, amphibians, animals)" P86037 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Hypsiboas raniceps (Chaco tree frog) (Hyla roeschmanni) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative as well as Gram-positive bacteria. And has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.18976634]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=10 ?M), Xanthomonas citri (MIC<2 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 29313 (MIC=20 ?M)." [Ref.18976634]20% hemolytic activity at 80 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18976634 Biochem Biophys Res Commun. 2008 Dec 26;377(4):1057-1061. "Magalh?es BS, Melo JA, Leite JR, Silva LP, Prates MV, Vinecky F, Barbosa EA, Verly RM, Mehta A, Nicoli JR, Bemquerer MP, Andrade AC, Bloch C Jr." Post-secretory events alter the peptide content of the skin secretion of Hypsiboas raniceps. DRAMP02125 IFGAILPLALGALKNLIK 18 "Hylin-a1 (Hy-a1; Frogs, amphibians, animals)" P85982 Not found Not found Hypsiboas albopunctatus (Spotted tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found 2N0O resolved by NMR. "Function: Has antibacterial activity against the Gram-positive bacteria and the Gram-negative bacteria. Has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.19056441]Gram-positive bacteria: Staphylococcus aureus ATCC 25926 (MIC=8 ?M), Enterococcus faecalis ATCC 29212 (MIC=16 ?M), Bacillus subtilis ATCC 19659 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=32 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=64 ?M);##Fungi: Candida albicans ATCC 90028 (MIC=16.7 ?M), C. krusei ATCC 6258 (MIC=16.7 ?M), C. parapsilosis ATCC 22019 (MIC=67 ?M), Cryptococcus neoformans ATCC 90012 (MIC=33.5 ?M)" [Ref.19056441]HC50=18 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19056441 Peptides. 2009 Feb;30(2):291-296. "Castro MS, Ferreira TC, Cilli EM, Crusca E Jr, Mendes-Giannini MJ, Sebben A, Ricart CA, Sousa MV, Fontes W." "Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus (spotted treefrog)." DRAMP02127 GLLGGLLGPLLGGGGGGGGGLL 22 "Leptoglycin (Gly-rich; Frogs, amphibians, animals)" P86267 Not found Not found Leptodactylus pentadactylus (Smokey jungle frog) (Rana pentadactyla) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial protein. Has antibacterial activity but not against Gram-positive bacteria Staphylococcus aureus, Micrococcus luteus and Enterococcus faecalis, yeasts Candida albicans and Candida tropicalis and dermatophytes fungi Microsporum canis and Trichophyton rubrum. No hemolytic activity was observed at the 2-200 microM range concentration. Tissue specificity: Expressed by the skin glands." "[Ref.19298834]Gram-negative bacteria: Escherichia coli ATCC 28922 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=8 ?M);##Fungi: Citrobacter freundii ATCC 8090 (MIC=75 ?M)" [Ref.19298834]Non-hemolytic activity was observed at 2-200 M concentration Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19298834 Toxicon. 2009 Jul;54(1):23-32. "Sousa JC, Berto RF, Gois EA, Fontenele-Cardi NC, Honrio JE Jr, Konno K, Richardson M, Rocha MF, Camargo AA, Pimenta DC, Cardi BA, Carvalho KM." Leptoglycin: a new glycine/leucine-rich antimicrobial peptide isolated from the skin secretion of the South American frog Leptodactylus pentadactylus (Leptodactylidae). DRAMP02128 FLGGILNTITGLL 13 "Kassorin-S (PreproKassorin-S; Frogs, amphibians, animals)" E6ZBE2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Kassina senegalensis (Senegal running frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide. Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Lacks ability to induce contraction of smooth muscle in isolated guinea pig urinary bladder. Elicits histamine release from rat peritoneal mast cells. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." Gram-positive bacterium: Staphylococcus aureus (MIC=30 ?M).##Yeast: Candida albicans (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21040978 Mol Immunol. 2011 Jan;48(4):442-451. "Chen H, Wang L, Zeller M, Hornshaw M, Wu Y, Zhou M, Li J, Hang X, Cai J, Chen T, Shaw C." "Kassorins: novel innate immune system peptides from skin secretions of the African hyperoliid frogs, Kassina maculata and Kassina senegalensis." DRAMP02129 FIKELLPHLSGIIDSVANAIK 21 "Kasstasin (Frogs, amphibians, animals)" G0LWV9 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Kassina maculata (African rhacophorid frog) (Hylambates maculatus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Peptide with potent vasoconstrictor properties. Has moderate antimicrobial activity. Not active against fungus C. albicans. Has hemolytic activity against horse erythrocytes. Tissue specificity: Expressed by the skin dorsal glands. Miscellaneous: Kasstasin is a derivation of Kassina, the taxon of origin, and the Ancient Greek word 'stasis' meaning 'stoppage of flow'." [Ref.21624426]Gram-positive bacterium: Staphylococcus aureus (MIC=55 ?M);##Gram-negative bacterium: Escherichia coli (MIC=110 ?M). [Ref.21624426]12.8% hemolytic activity at 125 M against defibrinated horse blood Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21624426 Biochimie. 2011 Sep;93(9):1537-1542. "Li X, Feng W, Zhou M, Ma C, Chen T, Zeller M, Hornshaw M, Wang L, Shaw C." "Kasstasin: A novel potent vasoconstrictor peptide from the skin secretion of the African red-legged running frog, Kassina maculata." DRAMP02130 GFLGPLLKLAAKGVAKVIPHLIPSRQQ 27 "Antimicrobial peptide 1 (XT-1; Frogs, amphibians, animals)" P84387 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E.coli and stronger activity against yeast C. albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells . Tissue specificity: Expressed by the skin glands." [Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacteria: Escherichia coli (MIC=6 ?M);##Fungi: Candida albicans (MIC=50 ?M) [Ref.11738090]HC50=90 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02131 GVWSTVLGGLKKFAKGGLEAIVNPK 25 "Antimicrobial peptide 2 (XT-2; Frogs, amphibians, animals)" P84382 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has very strong antibacterial activity against Gram-positive bacterium S. aureus and very weak activity against Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria: Escherichia coli (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02133 GVFLDALKKFAKGGMNAVLNPK 22 "Antimicrobial peptide 4 (XT-4; Frogs, amphibians, animals)" P84384 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and yeast C. albicans, and very weak activity against Gram-negative bacterium E.coli. Has strong hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." [Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria: Escherichia coli (MIC=18 ?M);##Fungi: Candida albicans (MIC>100 ?M). [Ref.11738090]HC50>150 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02135 GFLGSLLKTGLKVGSNLL 18 "Antimicrobial peptide 6 (XT-6; Frogs, amphibians, animals)" P84386 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E.coli and strong activity against yeast C. albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." "[Ref.11738090]Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=5 ?M);##Yeast: Candida albicans (MIC=40 ?M);##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 ?M), Staphylococcus aureus (MRSA) (MIC=7 ?M), Staphylococcus epidermidis 1420129 (MIC=3 ?M), S. saprophyticus 1950556 (MIC=13 ?M), Escherichia coli 25922 (MIC=6 ?M), Streptococcus group C 1541035 (MIC=3 ?M), Shigella sonnei 1840187 (MIC=35 ?M), Pseudomonas aeruginosa 0380972 (MIC=60 ?M), Enterobacter cloacae 1441323 (MIC=35 ?M)" [Ref.11738090]HC50=70 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02136 GLLGPLLKIAAKVGSNLL 18 "Antimicrobial peptide 7 (XT-7; Frogs, amphibians, animals)" P84381 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has very strong antibacterial activity against many Gram-negative bacteria and the Gram-positive bacteria S.pneumoniae and Enterococcus sp. There is moderate antimicrobial activity against the Gram-negative bacterium P.aeruginosa and yeast C. albicans and weaker activity against the Streptococcal strains and E.coli. Has hemolytic activity against human red blood cells (HC50=70 ?M). Seems to disrupt the membranes by adopting an alpha-helical conformation. Tissue specificity: Expressed by the skin glands. PTM: Amidation on Leu-18 is required to adopt an alpha-helical conformation in a hydrophobic solvent. The absence of amidation leads to a decrease in cationicity leading to a more than a 10-fold decrease in antimicrobial activities." "Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=5 ?M);##yeast Candida albicans (MIC=40 ?M).##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 ?M), Staphylococcus aureus (MRSA) (MIC=7 ?M), Staphylococcus epidermidis 1420129 (MIC=3 ?M), S. saprophyticus 1950556 (MIC=13 ?M), Escherichia coli 25922 (MIC=6 ?M), Streptococcus group C 1541035 (MIC=3 ?M), Shigella sonnei 1840187 (MIC=35 ?M), Pseudomonas aeruginosa 0380972 (MIC=60 ?M), Enterobacter cloacae 1441323 (MIC=35 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02142 GFLGPLLKLGLKGVAKVLPHLIPSRQQ 27 "CPF-SP1 (Frogs, amphibians, animals)" No entry found Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial" Not found Not found Not found None Comment: No comments found on DRAMP database "Acinetobacter baumannii (MIC=12,5; Klebsiella pneumoniae=25 " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21498136 Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun;6(2):206-212. "Mechkarska M, Eman A, Coquet L, Jr?me L, Jouenne T, Vaudry H, King JD, Takada K, Conlon JM." Genome duplications within the Xenopodinae do not increase the multiplicity of antimicrobial peptides in Silurana paratropicalis and Xenopus andrei skin secretions. DRAMP02219 GILSSFKGVAKGVAKNLAGKLLDELKCKITGC 32 "Ranatuerin-2AUa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana aurora aurora (Northern red-legged frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Activity against a range of Gram-positive and Gram-negative bacteria (minimum inhibitory concentrations<20 ?M) but low hemolytic activity against human erythrocytes. "[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=5 ?M), Pseudomonas aeruginosa (MIC=5 ?M), Enterobacter cloacae (MIC=5 ?M), Klebsiella pneumoniae (MIC=10 ?M), P. mirabilis (MIC>40 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=20 ?M), Staphylococcus epidermidis (MIC=20 ?M), Enterococcus faecalis (MIC>40 ?M), Streptococcus Group B (MIC=20 ?M);##Yeast: Candida albicans (MIC>40 ?M)" [Ref.15325526]HC50=290 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15325526 Dev Comp Immunol. 2005;29(1):83-90. "Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T." Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. DRAMP02220 GIMDTVKNVAKNLAGQLLDKLKCKITAC 28 "Ranatuerin-2PLa (Frogs, amphibians, animals)" A7WNV6 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 23-28." Gram-negative bacterium: Escherichia coli (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02221 GIMDTVKNAAKDLAGQLLDKLKCRITGC 28 "Ranatuerin-2PLb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02222 GLLDTIKNTAKNLAVGLLDKIKCKMTGC 28 "Ranatuerin-2PLc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02223 GIMDSVKNVAKNIAGQLLDKLKCKITGC 28 "Ranatuerin-2PLd (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02224 GIMDSVKNAAKNLAGQLLDTIKCKITAC 28 "Ranatuerin-2PLe (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02225 GIMDTVKNAAKDLAGQLDKLKCRITGC 27 "Ranatuerin-2PLf (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=23 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP18494 FIHHIIGGLFSAGKAIHRLIRRRRR 25 TP4 L0CKG3 Piscidin TP4 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) "Antibacterial, Antifungal, anticancer, wound healing, Anti-Gram+, Anti-Gram-, Antimicrobial" Protein level Alpha helix "1.0x sarkosyl can drive TP4 into a conformational change from a non-structure to an alpha-helical structure, and that LPS can also drive TP4 to an alpha-helical structure but with high hydrophobicity and low solubility." 5H2S Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. Has hemolytic activity. "[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=8 g/ml; MBC=16 g/ml), Methicillin-resistant Staphylococcus aureus (MIC=16 g/ml; MBC=32 g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa (MIC=64 g/ml; MBC=128 g/ml);##Fungi: Candida albicans (MIC=128 g/ml; MBC=128 g/ml)" "[Ref.29040295] 2% hemolysis at 0.78 g/ml, 5% hemolysis at 1.56 g/ml, 45% hemolysis at 3.13 g/ml, 85% hemolysis at 6.25 g/ml, 98% hemolysis at 12.50 g/ml, 100% hemolysis at 25.00 g/ml against mouse red blood cell" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet "bacterial outer membrane target protein, OprI-binding" 29040295 PLoS One. 2017 Oct 17;12(10):e0186442. "Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD." "Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4." DRAMP03002 GIGAVLKVLTTGLPALISWIKRKRQQ 26 "Melittin (Allergen Api m 3; Allergen Api m III; Insects, animals)" "P01501,P01503" Belongs to the melittin family MELT Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "2MLT, 3QRX, 1BH1" "Function: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. It increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. It acts synergistically with phospholipase A2. " "[Ref.29783753] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=2 M), Listeria monocytogenes CMCC 54004 (MIC=1 M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 M), Escherichia coli UB 1005 (MIC=2 M), Salmonella pullorum C7913 (MIC=8 M), Salmonella enterica subsp enterica CMCC 50071 (MIC=2 M)" [Ref.29859288] MHC=1 M against human red blood cell.##[Ref.2978375] 46.80% hemolysis at 2M against human red blood cell##[Ref.20472009] Wild-type melittin:AVG S.D.(%)=0.0770.002 (35) against human red blood cell. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (forms a transmembrane alpha-helix in the cell membrane.) 29859288##29783753##6309516##20472009##20403370##5300771 Gene. 2018 May 30. pii: S0378-1119(18)30617-6.##Molecules. 2018 May 19;23(5). pii: E1220. ##Eur J Biochem. 1983 Sep 1;135(1):123-126.##Peptides. 2010 Aug;31(8):1473-1479.##Toxicon. 2010 Sep 1;56(3):355-362.##Res Dev Tech Rep. 1967 Dec 5:1-13. "Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S.##Hou J, Liu Z, Cao S, Wang H, Jiang C, Hussain MA, Pang S.##Vlasak R, Unger-Ullmann C, Kreil G, Frischauf AM.##Sciani JM, Marques-Porto R, Louren?o Junior A, Orsi Rde O, Ferreira Junior RS, Barraviera B, Pimenta DC.##Ferreira Junior RS, Sciani JM, Marques-Porto R, Junior AL, Orsi Rde O, Barraviera B, Pimenta DC.##Fennell JF, Shipman WH, Cole LJ." Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro.##Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine AlphaS1-Casein.##Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin.##Identification of a novel melittin isoform from Africanized Apis mellifera venom.##Africanized honey bee (Apis mellifera) venom profiling: Seasonal variation of DRAMP02233 FISAIASMLGKFL 13 "Ranatuerin-6 (Frogs, amphibians, animals)" P82821 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Antiviral" Protein level Not found Not found None This peptide could inhibit HIV infection <10% at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). Gram-positive bacterium: Staphylococcus aureus (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02234 FLSAIASMLGKFL 13 "Ranatuerin-7 (Frogs, amphibians, animals)" P82822 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacterium S. aureus. Tissue specificity: Expressed by the skin glands." Gram-positive bacterium: Staphylococcus aureus (MIC=200 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02235 FISAIASFLGKFL 13 "Ranatuerin-8 (Frogs, amphibians, animals)" P82823 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacterium S. aureus. Tissue specificity: Expressed by the skin glands." Gram-positive bacterium: Staphylococcus aureus (MIC=130 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02236 FLFPLITSFLSKVL 14 "Ranatuerin-9 (Frogs, amphibians, animals)" P82824 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Antiviral" Protein level Not found Not found None "This peptide was found to be HIV active, EC50= 16.7 uM (Wang, G et al., 2010 Antimicrob Agents Chemother 54: 1343)." Gram-positive bacterium: Staphylococcus aureus (MIC=130 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02237 GLMDTIKGVAKTVAASWLDKLKCKITGC 28 "Ranatuerin-2Ya (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Not found "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Ranatuerin-2Ya showed appreciably greater cytolytic activity against HepG2 cells (LC(50)=20microM) than against erythrocytes (LC(50)>100microM). [Ref.19254736] Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M). [Ref.19254736] LC50>100 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP02238 GLADYWRTAFRANFANLGPGIRCKSARC 28 "Ranatuerin-2ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=6 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>32 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP02239 SMISVLKNLGKVGLGFVACKVNKQC 25 "Ranatuerin-1Ga (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grylio (North American pig frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=3.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M).##Yeast: Candida albicans (MIC=110 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10828493 Regul Pept. 2000 Jun 30;90(1-3):53-60. "Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM." Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio. DRAMP02241 GLLLDTLKGAAKDIAGIALEKLKCKITGCKP 31 "Ranatuerin-2G (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grylio (North American pig frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=19 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=150 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10828493 Regul Pept. 2000 Jun 30;90(1-3):53-60. "Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM." Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio. DRAMP01390 TSRCYIGYRRKVVCS 15 "Odorranain-T1 (OdT1; Frogs, amphibians, animals)" A6MBS1 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-T1 adopts 28.2% turn structure in water solution. None Function: Odorranain-T1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=17.50 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=35.00 g/ml), Bacillus subtilis (MIC=17.50 g/ml).##Yeast: Candida albicans (MIC=8.75 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01389 FLPPSPWKETFRTS 14 "Odorranain-S1 (OdS1; Frogs, amphibians, animals)" "A6MBS0, A6MBR9" Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-S1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=42.50 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=21.25 g/ml), Bacillus subtilis (MIC=85.00 g/ml).##Yeast: Candida albicans (MIC=21.25 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02251 GILSSFKGVAKGVAKDLAGKLLETLKCKITGC 32 "Ranatuerin-2CSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Alpha helix (4 helices; 25 residues) "In a 2,2,2-trifluoroethanol (TFE-d(3))-H(2)O solvent mixture, the structure is characterised by a full length helix-turn-helix conformation between residues I(2)-L(21), L(22)-L(25) and K(26)-T(30), respectively." 2K10 resolved by NMR. Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has Hemolytic activity against human erythrocytes. [Ref.17451843]Gram-negative bacterium:Escherichia coli ATCC 25726 (MIC=5 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10 ?M) [Ref.17451843] LD50=150 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys32) Disulfide bond between Cys27 and Cys32. L No cytotoxicity information found Not found 17451843##18387372 Peptides. 2007 Jun;28(6):1268-1274.##Biochim Biophys Acta. 2008 Jun;1784(6):924-929. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C.##Subasinghage AP, Conlon JM, Hewage CM." "Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group.##Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: identification of a full length helix-turn-helix motif." DRAMP02252 GLLDAIKDTAQNLFANVLDKIKCKFTKC 28 "Ranatuerin 2SKa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sakuraii (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M).##Yeast: Candida albicans (MIC>50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys28) Disulfide bond between Cys23 and Cys28. L No cytotoxicity information found Not found 17174009 Peptides. 2007 Mar;28(3):505-514. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii. DRAMP01108 GIGTKILGGVKTALKGALKELASTYVN 27 "Maximin-2 (Toads, amphibians, animals)" "P83081, P83086, Q58T49" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP03998 RKKWFW 6 PAF26 (Trp-rich; combinatorial library) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Synthetic Rich "In general, positively charged residues (arginine or lysine) and residues with aromatic rings (tryptophan or phenylalanine) rendered antifungal activity." None "Function: Antibacterial against Gram-negative bacterium. The antifungal mixture is also antibacterial, with a predominance of basic and aromatic residues." "[Ref.11976121] Gram-negative bacterium: Escherichia coli DH5 (MIC=160 ?M, IC50>80 ?M);##Fungi: Penicillium digitatum PHI-26 (MIC=20 ?M, IC50=11 1 ?M), Penicillium italicum PHI-1 (MIC=40 ?M, IC50=22 3 ?M), Botrytis cinerea CECT2100 (MIC=60 ?M, IC50=38 24 ?M), Fusarium oxysporum CECT2866 (MIC=80 ?M, IC50=45 4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11976121 Appl Environ Microbiol. 2002 May;68(5):2453-60. "Lpez-Garca B, Prez-Pay E, Marcos JF." Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library. DRAMP01107 GIGTKILGGVKTALKGALKELASTYAN 27 "Maximin-1 (Toads, amphibians, animals)" "P83080, Q58T87" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity. Toxic dose: LD50 is 8.2 mg/kg by intraperitoneal injection into mice. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml);##Virus: HIV-1 (IC50=15.5 ?g/ml, EC50=21.4 ?g/ml);##Cancer cell lines: C8166 (IC50=15.3 ?g/ml), Molt-4 (IC50=24.3 ?g/ml), BIU-87 (IC50=20.5 ?g/ml), T24 (IC50=35.4 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP02268 GWASKIGQTLGKIAKVGLKELIQPK 25 "Xenopsin precursor fragment (XPF; Frogs, amphibians, animals)" P07198 Belongs to the magainin family Not found Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: XPF has antimicrobial activity. Tissue specificity: XPF is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa, it is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli (MIC=16-31 ?g/ml), K. Pneumonae (MIC=62-125 ?g/ml), Pseudomonas aeruginosa (MIC=125-250 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 ?g/ml), Streptococcus faecalis (MIC=250-500 ?g/ml).##Yeast: Candida albicans (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1717472 J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02269 GVLSNVIGYLKKLGTGALNAVLKQ 24 "Antimicrobial peptide PGQ (PGQ; Frogs, amphibians, animals)" P39080 Belongs to the magainin family pgq Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix(potential) Not found None "Function: Antimicrobial peptide. Tissue specificity: Is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli (MIC=62-250 ?g/ml), K. Pneumonae (MIC=125-250 ?g/ml), Pseudomonas aeruginosa (MIC=250-500 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 ?g/ml), Streptococcus faecalis (MIC=250-500 ?g/ml).##Yeast: Candida albicans (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1717472 J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02271 GIGKFLHSAKKFGKAFVGEIMNS 23 "Magainin-2 (Magainin II; chain of Magainins; Frogs, amphibians, animals)" C0HKN6 Belongs to the gastrin/cholecystokinin family. Magainin subfamily. N/A Xenopus ruwenzoriensis (Uganda clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix "The secondary structure is shown to be helical in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution." "2MAG, 2LSA resolved by NMR." "Function: Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents. Tissue specificity: Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli D31 (MIC=5 ?g/ml), Klebsiella pneumoniae (MIC=10 ?g/ml), Escherichia coli (MIC=50 ?g/ml), Pseudomonas putida (MIC=10 ?g/ml), Citrobacter freundii (MIC=30 ?g/ml), Enterobacter cloacae (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Serratia marcescens (MIC=100 ?g/ml), Proteus mirabilis (MIC>100 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis (MIC=10 ?g/ml), Staphylococcus aureus (MIC=50 ?g/ml), Streptococcus fecalis (MIC>100 ?g/ml).##Protozoa: Paramecium caudatum (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=80 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 3299384##9090128##PubMed ID is not available Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-5453.##J Biomol NMR. 1997 Feb;9(2):127-135.##To be Published. "Zasloff M.##Gesell J, Zasloff M, Opella SJ.##Vermeer LS, Kozlowska J, Lorenz CD, Mason JA." "Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.##Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution.##All Atom Simulations of the Initial Binding of Magainin and Pleurocidin to Membranes Comprising a Mixture of Anionic and Zwitterionic" DRAMP02272 GMASKAGAIAGKIAKVALKAL 21 "PGLa (chain of PYLa/PGLa A; Frogs, amphibians, animals)" "Q99134, B7ZSG6, Q91826" Belongs to the gastrin/cholecystokinin family (Magainin subfamily) pgla-a AND pgla-b Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: PGLa display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa also displays antifungal activity against C. albicans ATCC 14053. Tissue specificity: Expressed by the skin glands. Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. Stored as active, processed peptides in large granules within the granular gland secretions of the skin. PTM: Leucine amide at position 21." "Gram-negative bacteria: Escherichia coli 25922 (MIC=62-125 ?g/ml), Klebsiella pneumoniae 13883 (MIC=250-500 ?g/ml), Pseudomonas aeruginosa 27853 (MIC=250-500 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=125-500 ?g/ml), Strepococcus faecalis (MIC>500 ?g/ml).##Yeast: Candida albicans 14053 (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 3606567##1717472 Biochem J. 1987 Apr 1;243(1):113-120.##J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Giovannini MG, Poulter L, Gibson BW, Williams DH.##Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones.##Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02273 KIAKVALKAL 10 "PGLa-H (chain of PYLa/PGLa A; Frogs, amphibians, animals)" "Q99134, B7ZSG6, Q91826" Belongs to the gastrin/cholecystokinin family (Magainin subfamily) pgla-a AND pgla-b Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: PGLa-H display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa-H shows moderate antibacterial activity against the multidrug-resistant methicillin-resistant S. aureus (MRSA) but exhibits hemolytic activity. Tissue specificity: Expressed by the skin glands. Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. Stored as active, processed peptides in large granules within the granular gland secretions of the skin. PTM: Leucine amide at position 10." "[Ref.22014884]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.7 ?g/ml), Bacillus subtilis (MIC=14.4 ?g/ml), Staphylococcus aureus (MRSA) (MIC=67.8 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.6 ?g/ml)" "[Ref.22014884]3.15% hemolytic activity at 100 g/mL, 7.95% hemolytic activity at 200 g/mL against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22014884##1717472 Int J Antimicrob Agents. 2011 Dec;38(6):510-515.##J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Hou F, Li J, Pan P, Xu J, Liu L, Liu W, Song B, Li N, Wan J, Gao H.##Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis.##Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02274 SAPRGCWTKSYPPKPCK 17 "Ranacyclin-E (Frogs, amphibians, animals)" P83663 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Has hemolytic activity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Tissue specificity: Expressed by the skin granular glands." "[Ref.14636071]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3 ?M), Staphylococcus lentus (MIC=7 ?M), Micrococcus luteus (MIC=5 ?M);##Gram-negative bacteria: Yersinia pseudotuberculosis YP III (MIC=9 ?M), Pseudomonas syringae pv tabaci (MIC=80 ?M);##Fungi: Candida tropicalis (MIC=7.4 ?M), C. guillermondii (MIC=3.4 ?M), Phytophthora nicotianae spores (MIC=32 ?M)." [Ref.14636071] It has 55% hemolytic activity at 100 M against human erythrocytes Cyclic Free Amidation Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Cell membrane 14636071 Biochemistry. 2003 Dec 2;42(47):14023-14035. "Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M." "Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity." DRAMP02275 GALRGCWTKSYPPKPCK 17 "Ranacyclin-T (Frogs, amphibians, animals)" P83719 Belongs to the frog skin active peptide family (Brevinin subfamily) RNCT Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None MOA: The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Has hemolytic activity. "[Ref.14636071]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3 ?M), Staphylococcus lentus (MIC=10 ?M), Micrococcus luteus (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=30 ?M), Yersinia pseudotuberculosis YP III (MIC=5 ?M), Pseudomonas syringae pv tabaci (MIC=16 ?M);##Fungi: Candida albicans ATCC 10231 (MIC=22 ?M), Candida tropicalis (MIC=14 ?M), C. guillermondii (MIC=1 ?M), Phytophthora nicotianae spores (MIC=16 ?M)." [Ref.14636071] It has 20% hemolytic activity at 100 M against human erythrocytes Cyclic Free Amidation Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Cell membrane 14636071 Biochemistry. 2003 Dec 2;42(47):14023-14035. "Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M." "Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity." DRAMP02276 AALKGCWTKSIPPKPCSGKR 20 "Ranacyclin B3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana grahami (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=11.7 ?M).##Yeast: Candida albicans (MIC=23.4 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02277 AALRGCWTKSIPPKPCSGKR 20 "Ranacyclin B5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana grahami (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=5.8 ?M).##Yeast: Candida albicans (MIC=23.1 ?M) No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02278 AALRGCWTKSIPPKPCPGKR 20 "Ranacyclin-B-RL1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana livida (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus (MIC=5.8 ?M), Bacillus subtilis (MIC=46.2 ?M);##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02279 SALVGCWTKSYPPKPCFGR 19 "Ranacyclin-B-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana nigrovittata (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02280 SALVGCGTKSYPPKPCFGR 19 "Ranacyclin-B-RN2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana nigrovittata (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=12.7 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02281 SALVGCWTKSYPPNPCFGRG 20 "Ranacyclin-B-RN6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana nigrovittata (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=11.7 ?M).##Yeast: Candida albicans (MIC=46.7 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02282 SALVGCWTKSWPPKPCFGRG 20 "Ranacyclin-B-LK1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana nigrovittata (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=23 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02283 SALVGCWTKSWPPKPCFGR 19 "Ranacyclin-B-LK2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana nigrovittata (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=11.8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02288 FIGPVLKIAAGILPTAICKIFKKC 24 "Gaegurin-RN1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells.. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=2.34 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=4.69 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=18.75 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 ?g/ml)" [Ref.19778602] It has 46.13 1.49% hemolytic activity at 100 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP02289 FVGPVLKIAAGILPTAICKIYKKC 24 "Gaegurin-RN4 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=1.17 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=2.34 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=2.34 ?g/ml)." [Ref.19778602] It has 18.64 0.25% hemolytic activity at 100 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP02290 FLGPIIKIATGILPTAICKFLKKC 24 "Gaegurin-RN5 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=3.75 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=62.50 ?g/ml), Bacillus subtilis (MIC=4.69 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 ?g/ml)." [Ref.19778602] It has no detectable hemolysis at the concentration up to 100 g/ml Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP02291 SLFSLIKAGAKFLGKNLLKQGACYAACKASKQC 33 "Gaegurin-1 (Gaegurin 1; GGN1; Frogs, amphibians, animals)" P80395 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN1 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has hemolytic activity against rabbit red cells. "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=5 ?g/ml), Staphylococcus epidermidis (MIC=50 ?g/ml), Bacillus subtilis (MIC=50 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=100 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=25 ?g/ml)." "[Ref.7999137] It has 0.04% hemolytic activity at 0.1 g/ml, 0.14% hemolytic activity at 1 g/ml, 0.51% hemolytic activity at 10 g/ml, 0.59% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung J-E, Lee BJ.1994" "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02292 GIMSIVKDVAKNAAKEAAKGALSTLSCKLAKTC 33 "Gaegurin-2 (Gaegurin 2; GGN2; Frogs, amphibians, animals)" P80396 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN2 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=75 ?g/ml).##Fungi: Saccharomyces cerevisiae (MIC=150 ?g/ml), Candida albicans (MIC=150 ?g/ml), Salmonella typhimurium (MIC=150 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.19% hemolytic activity at 0.1 g/ml, 0.16% hemolytic activity at 1 g/ml, 0.31% hemolytic activity at 10 g/ml, 0.82% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02293 GIMSIVKDVAKTAAKEAAKGALSTLSCKLAKTC 33 "Gaegurin-3 (Gaegurin 3; GGN3; Frogs, amphibians, animals)" P80397 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN3 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=75 ?g/ml).##Fungi: Saccharomyces cerevisiae (MIC>200 ?g/ml), Candida albicans (MIC>200 ?g/ml), Salmonella typhimurium (MIC=150 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.11% hemolytic activity at 0.1 g/ml, 0.12% hemolytic activity at 1 g/ml, 0.35% hemolytic activity at 10 g/ml, 1.20% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02294 GILDTLKQFAKGVGKDLVKGAAQGVLSTVSCKLAKTC 37 "Gaegurin-4 (Gaegurin 4; GGN4; Frogs, amphibians, animals)" "P80398, Q91328, Q98TA6" Belongs to the frog skin active peptide family (Brevinin subfamily) GGN4 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (3 helices; 22 residues) "In 100% H2O, Gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34 (Ref.2)." 2G9L resolved by NMR. "Function: Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. Has hemolytic activity against rabbit red cells. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 31-37." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=100 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=75 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=200 ?g/ml), Candida albicans (MIC=200 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.50% hemolytic activity at 0.1 g/ml, 0.74% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 1.67% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 7999137##17141187##11004488 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.##Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-597.##Biochim Biophys Acta. 2000 Jun 21;1492(1):185-190. "Park JM, Jung JE, Lee BJ.##Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH.##Kwon SY, Carlson BA, Park JM, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa.##Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.##Structural organization and expression of the gaegurin 4 gene of Rana rugosa." DRAMP02295 FLGALFKVASKVLPSVFCAITKKC 24 "Gaegurin-5 (Gaegurin 5; GGN5; Brevinin-1EMa; Frogs, amphibians, animals)" "P80399, Q91329" Belongs to the frog skin active peptide family (Brevinin subfamily) GGN5 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Not found Not found None "Function: Has low hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. PTM: Problely contains one disulfide bond 18-24." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=50 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=50 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=50 ?g/ml), Candida albicans (MIC=50 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.19% hemolytic activity at 0.1 g/ml, 0.31% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 1.01% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02296 FLPLLAGLAANFLPTIICKISYKC 24 "Gaegurin-6 (Gaegurin 6; GGN6; Frogs, amphibians, animals)" P80400 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN6 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has low hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. PTM: Problely contains one disulfide bond 18-24." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=50 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=50 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=50 ?g/ml), Candida albicans (MIC=50 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.39% hemolytic activity at 0.1 g/ml, 0.62% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 0.86% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02300 VIDDLKKVAKKVRRELLCKKHHKKLN 26 "Guentherin (AMP-3; Frogs, amphibians, animals)" P84859 Not found Not found Rana guentheri (Gunther's frog) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Antimicrobial peptide. Active against the Gram-positive bacteria. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=35.5 ?g/ml), Bacillus subtilis (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16979798 Peptides. 2006 Dec;27(12):3077-3084. "Zhou J, McClean S, Thompson A, Zhang Y, Shaw C, Rao P, Bjourson AJ." Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri. DRAMP02306 IIEKLVNTALGLLSGL 16 "Riparin-2.1 (Frogs, amphibians, animals)" P86127 Not found Not found Crinia riparia (Streambank froglet) (Flinders Ranges froglet) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Has antibacterial activity. Lacks antibacterial activity against the Gram-negative bacteria E. cloacae and E. coli, and against the Gram-positive bacteria B. cereus, E. faecalis, L. innocua, M. luteus, S. aureus, S. epidermidis and S. uberis. Does not inhibit the formation of NO by neuronal nitric oxide synthase. Tissue specificity: Expressed by the skin glands." Gram-positive bacterium: Lactococcus lactis (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16470724 Rapid Commun Mass Spectrom. 2006;20(5):797-803. "Maselli VM, Bilusich D, Bowie JH, Tyler MJ." Host-defence skin peptides of the Australian streambank froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry. DRAMP02307 GLADFLNKAVGKVVDFVKS 19 "Deserticolin-1 (Frogs, amphibians, animals)" P86136 Not found Not found Crinia deserticola (Desert froglet) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacteria. Inhibits the formation of NO by neuronal nitric oxide synthase with an IC50 of 2.4 ?M. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=25 ?M), Streptococcus uberis (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18601958 Regul Pept. 2008 Nov 29;151(1-3):80-87. "Jackway RJ, Pukala TL, Maselli VM, Musgrave IF, Bowie JH, Liu Y, Surinya-Johnson KH, Donnellan SC, Doyle JR, Llewellyn LE, Tyler MJ." "Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: structure, activity and evolutionary trends." DRAMP02308 IIGHLIKTALGMLGL 15 "Signiferin-2.1 (Frogs, amphibians, animals)" P86131 Not found Not found Crinia signifera (Common eastern froglet) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Has antibacterial activity against a wide spectrum of Gram-positive bacteria. Lacks antibacterial activity against the Gram-negative bacteria E. cloacae and E. coli. Inhibits the formation of NO by neuronal nitric oxide synthase with an IC50 of 12.4 ?M. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Bacillus cereus (MIC=25 ?M), Enterococcus faecalis ATCC 29212 (MIC=100 ?M), Leuconostoc lactis (MIC=12 ?M), Listeria innocua (MIC=50 ?M), Micrococcus luteus ATCC 9341 (MIC=25 ?M), Staphylococcus aureus ATCC 29213 (MIC=12 ?M), Staphylococcus epidermidis ATCC14990 (MIC=25 ?M), Streptococcus uberis (MIC=25 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15317042##16470724##18601958 Rapid Commun Mass Spectrom. 2004;18(18):2155-2161.##Rapid Commun Mass Spectrom. 2006;20(5):797-803.##Regul Pept. 2008 Nov 29;151(1-3):80-87. "Maselli VM, Brinkworth CS, Bowie JH, Tyler MJ.##Maselli VM, Bilusich D, Bowie JH, Tyler MJ.##Jackway RJ, Pukala TL, Maselli VM, Musgrave IF, Bowie JH, Liu Y, Surinya-Johnson KH, Donnellan SC, Doyle JR, Llewellyn LE, Tyler MJ." "Host-defence skin peptides of the Australian Common Froglet Crinia signifera: sequence determination using positive and negative ion electrospray mass spectra.##Host-defence skin peptides of the Australian Streambank Froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry.##Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: structure, activity and evolutionary trends." DRAMP02312 SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAHRVGAGAPVYL 51 "Hipposin (fish, chordates, animals)" P59890 Belongs to the histone H2A family Not found Hippoglossus hippoglossus (Atlantic halibut) "Antimicrobial, Antibacterial" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram+ (MIC=0.3 ?M);##Gram- (MIC=0.3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12637028 Biochim Biophys Acta. 2003 Mar 21;1646(1-2):207-215. "Birkemo GA, Luders T, Andersen O, Nes IF, Nissen-Meyer J" "Hipposin, a histone-derived antimicrobial peptide in Atlantic halibut (Hippoglossus hippoglossus L.)." DRAMP02314 RCRFCCRCCPRMRGCGICCRF 21 "Hepcidin (fish, chordates, animals)" A1Z0M0 Belongs to the hepcidin family hamp Larimichthys crocea (Croceine croaker) (Pseudosciaena crocea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Tissue specificity: Expressed in all tissues tested, with highest levels of expression in kidney and lowest levels in liver. Intra-peritoneal injection of lipopolysaccharide results in increased expression in heart, spleen and stomach, but not in kidney or liver. PTM: Contains four disulfide bonds 2-19; 5-8; 6-15; 9-18." "Gram-negative bacteria: Vibrio alginolyticus(MIC=24 ?M), V. fluvialis, V. harveyis (MIC=12 ?M) and Vibrio parahaemolyticus (MIC=6 ?M), Aeromonas hydrophila (MIC=6 ?M), Escherichia coli (MIC=24 ?M), Escherichia coli BL21(DE3)plysS (MIC=6 ?M);##Gram-positive bacteria: Bacillus cereus (MIC=24 ?M), Bacillus subtilis (MIC=6 ?M), C. glutamicum (MIC=3 ?M), Micrococcus luteus (MIC=3 ?M), M. lysodeikticus, Staphylococcus aureus (MIC=6 ?M) and S.epidermis (MIC=12 ?M).##Fungi: Aspergillus niger (MIC=24 ?M), F;##Graminearum (MIC=24 ?M) and Fusarium solani (MIC=24 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys19; Cys5 and Cys8; Cys6 and Cys15,Cys9 and Cys18." L No cytotoxicity information found Not found 19150638##19344770 Peptides. 2009 Apr;30(4):638-646.##Fish Shellfish Immunol. 2009 Jun;26(6):864-870. "Wang KJ, Cai JJ, Cai L, Qu HD, Yang M, Zhang M.##Zhang J, Yan Q, Ji R, Zou W, Guo G." "Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide.##Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea." DRAMP02315 FFGWLIKGAIHAGKAIHGLIHRRRH 25 "Chrysophsin-1 (fish, chordates, animals)" P83545 Belongs to the pleurocidin family Not found Chrysophrys major (Red sea bream) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Shows hemolytic activity human red blood cells. "[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=10 ?M), S.iniae F-8502 (MIC=2.5 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=2.5 ?M), Vibriopenaeicida KHA (MIC=10 ?M), V. harveyi ATCC 14126 (MIC=2.5 ?M), V. vulnificus ATCC 33148 (MIC=5 ?M), Aeromonas salmonicida NCMB 1102 (MIC=10 ?M), Pseudomonas putida ATCC 12633 (MIC=40 ?M)." "[Ref.12581207]10% hemolytic activity at 0.25 M, 80% hemolytic activity at 1 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12581207 Eur J Biochem. 2003 Feb;270(4):675-686. "Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T." "Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major." DRAMP02316 FFGWLIRGAIHAGKAIHGLIHRRRH 25 "Chrysophsin-2 (fish, chordates, animals)" P83546 Belongs to the pleurocidin family Not found Chrysophrys major (Red sea bream) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Shows hemolytic activity human red blood cells. "[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=5 ?M), S.iniae F-8502 (MIC=1.5 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=1.25 ?M), Vibriopenaeicida KHA (MIC=5 ?M), V. harveyi ATCC 14126 (MIC=5 ?M), V. vulnificus ATCC 33148 (MIC=2.5 ?M)." "[Ref.12581207]10% hemolytic activity at 0.25 M, 70% hemolytic activity at 1 M against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12581207 Eur J Biochem. 2003 Feb;270(4):675-686. "Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T." "Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major." DRAMP02317 FIGLLISAGKAIHDLIRRRH 20 "Chrysophsin-3 (fish, chordates, animals)" P83547 Belongs to the pleurocidin family Not found Chrysophrys major (Red sea bream) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Shows hemolytic activity human red blood cells. "[Ref.12581207]Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=0.25 ?M), Lactococcus garvieae ATCC 49156 (MIC=10 ?M), S.iniae F-8502 (MIC=10 ?M);##Gram-negative bacteria: Escherichia coli WT-2 (MIC=0.25 ?M), Vibrio anguillarum ATCC 19264 (MIC=10 ?M), Vibriopenaeicida KHA (MIC=10 ?M), V. harveyi ATCC 14126 (MIC=5 ?M), V. vulnificus ATCC 33148 (MIC=10 ?M), Aeromonas salmonicida NCMB 1102 (MIC=10 ?M), Pseudomonas putida ATCC 12633 (MIC=40 ?M)." "[Ref.12581207]0% hemolytic activity at 0.25 M, 10% hemolytic activity at 1 M against human erythrocytes." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12581207 Eur J Biochem. 2003 Feb;270(4):675-686. "Iijima N, Tanimoto N, Emoto Y, Morita Y, Uematsu K, Murakami T, Nakai T." "Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major." DRAMP02318 FIGGIISFFKRLF 13 "Grammistin Pp1 (Group II grammistin; fish, chordates, animals)" P69842 Belongs to the grammistin family (Group 2 subfamily) Not found Pogonoperca punctata (Clown grouper) (Bearded grouper) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=3.13 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=3.13 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC>50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Fish. Sci. 2001 Oct;67:928-933. "Yokota H, Nagashima Y, Shiomi K." Interaction of grammistins with lipids and their antibacterial activity. DRAMP02320 FIGGIISFIKKLF 13 "Grammistin PpIIb (Group II grammistin; fish, chordates, animals)" P69844 Belongs to the grammistin family (Group 2 subfamily) Not found Pogonoperca punctata (Clown grouper) (Bearded grouper) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Has antibacterial activities. "[Ref.Fish. Sci. 2001 Feb;67:163-169.]Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=3.13 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC>50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=12.5 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Phospholipids PubMed ID is not available Fish. Sci. 2001 Feb;67:163-169. "Shiomi K, Yokota H, Nagashima Y, Ishida M." "Primary and secondary structures of grammistins, peptide toxins isolated from the skin secretion of the soapfish Pogonoperca punctata." DRAMP02321 NWRKILGQIASVGAGLLGSLLAGYE 25 "Grammistin Pp3 (Group III grammistin; fish, chordates, animals)" P69847 Belongs to the grammistin family (Group 3 subfamily) Not found Pogonoperca punctata (Clown grouper) (Bearded grouper) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has hemolytic activity. Thanks to its abundant amphiphilic alpha-helices, it may integrate into membrane phospholipids, leading to lysis of the membrane." "[Ref.Fish. Sci. 2001 Oct;67:928-933.]Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=50 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=50 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC>50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=12.5 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=50 ?g/ml)." [Ref.Fish. Sci. 2001 Oct;67:928-933.]75 HU/mg hemolytic activity against horse erythrocytes(1 HU was defined as the amount of peptide causing 50% hemolysis) Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Fish. Sci. 2001 Oct;67:928-933. "Yokota H, Nagashima Y, Shiomi K." Interaction of grammistins with lipids and their antibacterial activity. DRAMP02324 AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS 30 "SAMP H1 (fish, chordates, animals)" "P84408, Q5GMQ6" Belongs to the histone H1/H5 family Not found Salmo salar (Atlantic salmon) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=2 ?M), Aeromonas salmonicida subsp salmonicida (MIC=4 ?M), Vibrio anguillarum (MIC=1 ?M) Salmonella typhimurium (MIC=4 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=2 ?M), Listeria ivanovii (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15917539 Antimicrob Agents Chemother. 2005 Jun;49(6):2399-2406. "Luders T, Birkemo G.A, Nissen-Meyer J, Andersen O, Nes I.F." Proline conformation-dependent antimicrobial activity of a proline-rich histone H1 N-terminal peptide fragment isolated from the skin mucus of Atlantic salmon. DRAMP02330 FFHHIFRGIVHVGKTIHRLVTG 22 "Piscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)" Q8UUG0 Belongs to the pleurocidin family Not found Morone saxatilis (Striped bass) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "2JOS, 2OJM resolved by NMR." Function: Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria. Also has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores. "[Ref.11713517]Gram-positive bacteria: Enterococcus faecalis VRE (MIC=5-10 ?M), E. faecalis (MIC=2.5-5 ?M), Listeria monocytogenes (MIC=2.5-5 ?M), Micrococcus luteus (MIC=10-20 ?M), Staphylococcus aureus MRSA (MIC=1.25-2.5 ?M), S. epidermitis (MIC=5-10 ?M), S. saprophiticus (MIC=5-10 ?M), Staphylococcus xylosus (MIC>20 ?M), S. agalactiae (MIC=1.25-2.5 ?M), S. bovis (MIC=1.25-2.5 ?M), S. equisimilis (MIC=2.5-5 ?M), S. mitis (MIC=1.25-2.5 ?M), S. Pneumonae (MIC=1.25-2.5 ?M), S. pyrogenes (MIC=1.25-2.5 ?M), Streptococcus iniae KST740 ak (MIC=1.25-2.5 ?M), S. iniae KSTSi 6P (MIC=1.25-2.5 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 ?M), Burkholderia cepacia (MIC>20 ?M), Vibrio Cholera (MIC=2.5-5 ?M), Escherichia coli (MIC=5-10 ?M), Enterobacter cloacae (MIC=10-20 ?M), E. Aerogenes (MIC=10-20 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), K. oxytoca (MIC=5-10 ?M), Salmonella choleraesuis (MIC=10-20 ?M), S. typhimurium (MIC=10-20 ?M), S. arizonae (MIC=10-20 ?M), Serratia marcescens (MIC>20 ?M), Shigella flexneri (MIC=2.5-5 ?M), S. sonnei (MIC=5-10 ?M), Yersinia enterocolitica (MIC=2.5-5 ?M); Fungi: Neurospora crassa (MIC=1.56-3.12 ?M), A. fumigatus (MIC=50-100 ?M), F. axysporum (MIC=0.78-1.56 ?M), F. culmorum (MIC=0.39-0.78 ?M), C. ablicans (MIC=10-20 ?M), C. glabrata (MIC=10-20 ?M), C. lusitania (MIC=10-20 ?M), C. tropacalis (MIC=10-20 ?M)." "[Ref.11713517]10% hemolytic activity at 5 g/mL, 60% hemolytic activity at 10 g/mL, 100% hemolytic activity at 50 g/mL against human erythrocytes " Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11713517 Nature. 2001 Nov 15;414(6861):268-269. "Silphaduang U, Noga EJ." Peptide antibiotics in mast cells of fish. DRAMP02331 FFHHIFRGIVHVGKTIHKLVTG 22 "Piscidin-2 (Pis-2; fish, chordates, animals)" Q8UUG2 Belongs to the pleurocidin family Not found Morone chrysops (White bass) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Seems to disrupt the membranes by adopting an alpha helical conformation. Tissue specificity: Expressed in gill, skin, intestine, spleen, anterior kidney, and blood cells." "Gram-positive bacteria: Enterococcus faecalis (MIC=5-10 ?M), E. faecalis (MIC=2.5-5 ?M), Listeria monocytogenes (MIC=2.5-5 ?M), Micrococcus luteus (MIC=10-20 ?M), Staphylococcus aureus (MIC=1.25-2.5 ?M), S. epidermidis (MIC=5-10 ?M), S. saprophiticus (MIC=5-10 ?M), S. xylosus (MIC>20 ?M), Streptococcus agalactiae (MIC=1.25-2.5 ?M), S. bovis (MIC=1.25-2.5 ?M), S. equisimilis (MIC=2.5-5 ?M), S. mitis (MIC=1.25-2.5 ?M), Streptococcus pneumoniae (MIC=1.25-2.5 ?M), Streptococcus pyogenes (MIC=1.25-2.5 ?M), S. iniae KST740ak (MIC=1.25-2.5 ?M), S. iniae KSTSi 6P (MIC=1.25-2.5 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 ?M), Burkholderia cepacia (MIC>20 ?M), Vibrio cholera (MIC=2.5-5 ?M), Escherichia coli (MIC=5-10 ?M), Moraxella catarrhalis (MIC=2.5-5 ?M), Neisseria gonorrhoeae (MIC>20 ?M), Pseudomonas aeruginosa (MIC=5-10 ?M), Enterobacter cloacae (MIC=10-20 ?M), E. aerogenes (MIC=10-20 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), K. oxytoca (MIC=5-10 ?M), Salmonella choleraesuis (MIC=10-20 ?M), Salmonella typhimurium (MIC=10-20 ?M), S. arizonae (MIC=10-20 ?M), Serratia marcescens (MIC>20 ?M), Shigella flexneri (MIC=2.5-5 ?M), S. sonnei (MIC=5-10 ?M), Yersinia enterocolitica (MIC=2.5-5 ?M).##Fungi: Neurospora crassa (MIC=1.56-3.12 ?M), Aspergillus fumigatus (MIC=50-100 ?M), Fusarium oxysporum (MIC=0.78-1.56 ?M), F. culmorum (MIC=0.39-0.78 ?M), Candida albicans (MIC=10-20 ?M), C. glabrata (MIC=10-20 ?M), C. lusitania (MIC=10-20 ?M), C. tropicalis (MIC=10-20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11739390 J Biol Chem. 2002 Feb 15;277(7):5030-5039. "Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Shimizu C, Bulet P." "Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass." DRAMP02336 KAVAAKKSPKKAKKPATPKKAAKSPKKVKKPAAAAKKAAKSPKKATKAAKPKAAKPKAAKAKKAAPKKK 69 "Oncorhyncin II (Oncorhyncin 2; fish, chordates, animals)" "P06350, P83374" Belongs to the histone H1/H5 family Not found Oncorhynchus mykiss (Rainbow trout) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Potentially important role in mucosal defense. "Gram-positive bacteria: Planococcus citreus (MIC=0.2-0.4 ?M), Micrococcus luteus (MIC=0.2-0.4 ?M);##Gram-negative bacteria: Escherichia coli (MIC=0.4-0.8 ?M), Listonella anguillarum (MIC=0.4-0.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12969798 Dev Comp Immunol. 2004 Feb;28(2):127-138. "Fernandes JM, Molle G, Kemp GD, Smith VJ." "Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss." DRAMP02337 PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAG 66 "Oncorhyncin III (Oncorhyncin 3; fish, chordates, animals)" "P02315, P83338" Belongs to the HMGN family Not found Oncorhynchus mykiss (Rainbow trout) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Plays a role in mucosal innate host defence. "Gram-positive bacteria: Aerococcus viridans (MIC=0.06-0.12 ?M), Bacillus subtilis (MIC=0.25-0.5 ?M), Micrococcus luteus (MIC=0.12-0.25 ?M), Planococcus citreus (MIC=0.06-0.12 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>0.5 ?M), Aeromonas salmonicida 004 (MIC>0.5 ?M), Escherichia coli (MIC=0.25-0.5 ?M), Listonella anguillarum (MIC=0.25-0.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet DNA 12713443 Biochem J. 2003 Jul 15;373(Pt 2):621-628. "Fernandes J.M.O, Saint N, Kemp G.D, Smith V.J." "Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss." DRAMP02347 GKGRWLERIGKAGGIIIGGALDHL 24 "NRC-1 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "C-terminal NH2, this NRC seris of peptides was identified by gene analysis and biological activity verified using synthetic peptides. " "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 ?g/ml), Aeromonas salmonicida 97-4 (MIC=64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), Escherichia coli UB1005 (MIC=32 ?g/ml), Escherichia coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02348 WLRRIGKGVKIIGGAALDHL 20 "NRC-2 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1a) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>128 ?g/ml), Aeromonas salmonicida 97-4 (MIC=128 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), E. coli UB1005 (MIC=64 ?g/ml), E. coli DC2 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02349 GRRKRKWLRRIGKGVKIIGGAALDHL 26 "NRC-3 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1a-1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), Aeromonas salmonicida 97-4 (MIC=4 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), Escherichia coli UB1005 (MIC=8 ?g/ml), Escherichia coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=8 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02350 GWGSFFKKAAHVGKHVGKAALTHYL 25 "Pleurocidin (NRC-4; fish, chordates, animals)" "P81941, P81619, Q9PRJ9, Q90ZY0, Q90VW6" Belongs to the pleurocidin family ple1 AND ple2 Pseudopleuronectes americanus (Winter flounder 2-2.1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 19 residues) "From NMR structural studies with the uniformly (15)N-labeled peptide, a structure of pleurocidin is determined to be in a random coil conformation in aqueous solution whereas it assumes an alpha-helical structure in TFE and in dodecylphosphocholine (DPC) micelles.(Ref.2)" 1Z64?resolved by NMR. May play a role in innate host defense. "Gram-negative bacteria: Escherichia coli (MIC=2.2-3.3 ?M), Leucothrix mucor (MIC>35.0 ?M), Serratia marcescens (MIC>35.0 ?M), Pseudomonas aeruginosa (MIC>35.0 ?M), Aeromonas salmonicida (MIC=17.7-35.0 ?M), Cytophaga aquatilis (MIC=2.2-4.4 ?M), Pasteurella haemolytica (MIC=4.4-8.8 ?M), Salmonella typhimurium I (MIC=8.8-17.7 ?M), Salmonella typhimurium II (MIC=8.8-17.7 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=1.1-2.2 ?M), Staphylococcus aureus (MIC=17.7-35.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9115266 J Biol Chem. 1997 May 2;272(18):12008-12013. "Cole A.M, Weis P, Diamond G." "Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder." DRAMP02351 FFRLLFHGVHHVGKIKPRA 19 "NRC-10 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder Z) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), Aeromonas salmonicida 97-4 (MIC=32 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), Escherichia coli UB1005 (MIC=32 ?g/ml), Escherichia coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus C623 (MRSA) (MIC=64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02352 GWKKWLRKGAKHLGQAAIK 19 "NRC-16 (fish, chordates, animals)" No entry found Not found Not found Glyptocephalus cynoglossus (Witch flounder GC3.8-t) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=1 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=0.5 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=16 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=1 ?g/ml), E. coli UB1005 (MIC=2 ?g/ml), E. coli DC2 (MIC=0.5 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02354 FFRLLFHGVHHGGGYLNAA 19 "Pleurocidin-like peptide WFY (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida A449 field isolate (MIC>64 ?g/ml), A. salmonicida 97-4 field isolate (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC4908 triple (MIC=64 ?g/ml), Salmonella typhimurium 14028s (MIC>64 ?g/ml), Salmonella typhimurium MS7953s (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis (human clinical isolates) (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) (MIC>64 ?g/ml).##Fungi: Candida albica (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12950255 Eur J Biochem. 2003 Sep;270(18):3720-3730. "Douglas SE, Patrzykat A, Pytyck J, Gallant JW." "Identification, structure and differential expression of novel pleurocidins clustered on the genome of the winter flounder, Pseudopleuronectes americanus (Walbaum)." DRAMP02357 FLGALIKGAIHGGRFIHGMIQNHH 24 "Pleurocidin-like peptide WF3 (NRC-5; fish, chordates, animals)" Q90VW7 Belongs to the pleurocidin family ple3 Pseudopleuronectes americanus (Winter flounder 3) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), Escherichia coli UB1005 (MIC=64 ?g/ml), Escherichia coli DC2 (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506##11113283 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.##Dev Comp Immunol. 2001 Mar;25(2):137-147. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.##Douglas SE, Gallant JW, Gong Z, Hew C." "Novel antimicrobial peptides derived from flatfish genes.##Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum)." DRAMP02358 GWGSIFKHGRHAAKHIGHAAVNHYL 25 "Pleurocidin-like peptide WF4 (NRC-6; fish, chordates, animals)" "Q90ZX8, Q90ZX9" Belongs to the pleurocidin family ple4 Pseudopleuronectes americanus (Winter flounder 4-1.1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=4 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=16 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC=32 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506##11113283 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.##Dev Comp Immunol. 2001 Mar;25(2):137-147. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.##Douglas SE, Gallant JW, Gong Z, Hew C." "Novel antimicrobial peptides derived from flatfish genes.##Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum)." DRAMP02359 RWGKWFKKATHVGKHVGKAALTAYL 25 "Pleurocidin-like peptide YT2 (NRC-7; fish, chordates, animals; Predicted)" Q7SZH1 Not found ple Limanda ferruginea (Yellowtail flounder YT2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=2 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=64 ?g/ml).##Yeast: Candida albicans C627 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02360 GWKSVFRKAKKVGKTVGGLALDHYLG 26 "Pleurocidin-like peptide AP1 (NRC-11; fish, chordates, animals; Predicted)" Q7SZH4 Not found ple Hippoglossoides platessoides (American plaice AP1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 ?g/ml), A. salmonicida 97-4 (MIC=8 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=32 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=16?g/ml), E. coli DC2 (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC=32 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02361 GWKKWFNRAKKVGKTVGGLAVDHYLG 26 "Pleurocidin-like peptide AP2 (NRC-12; fish, chordates, animals; Predicted)" Q7SZH3 Not found ple Hippoglossoides platessoides (American plaice AP2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), E. coli UB1005 (MIC=8 ?g/ml), E. coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: S. epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02362 GWRTLLKKAEVKTVGKLALKHYL 23 "Pleurocidin-like peptide AP3 (NRC-13; fish, chordates, animals; Predicted)" Q7SZH2 Not found ple Hippoglossoides platessoides (American plaice AP3) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=2 ?g/ml).##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02363 AGWGSIFKHIFKAGKFIHGAIQAHND 26 "Pleurocidin-like peptide GcSc4C5 (NRC-14; fish, chordates, animals)" Q7SZH0 Not found ple Glyptocephalus cynoglossus (Witch flounder GcSc4C5) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=32 ?g/ml), A. salmonicida 97-4 (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=16 ?g/ml), E. coli UB1005 (MIC=16 ?g/ml), E. coli DC2 (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02364 GFWGKLFKLGLHGIGLLHLHL 21 "Pleurocidin-like peptide GcSc4B7 (NRC-15; fish, chordates, animals; Predicted)" Q7SZG9 Not found ple Glyptocephalus cynoglossus (Witch flounder GcSc4B7) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 ?g/ml), A. salmonicida 97-4 (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=16 ?g/ml), Pseudomonas aeruginosa K799 (MIC=8 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=8 ?g/ml), E. coli UB1005 (MIC=8 ?g/ml), E. coli DC2 (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 ?g/ml).##Yeast: Candida albicans C627 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02365 GWKKWLRKGAKHLGQAAIKGLAS 23 "Pleurocidin-like peptide GC3.8 (NRC-17; fish, chordates, animals; Predicted)" Q7SZG8 Not found ple Glyptocephalus cynoglossus (Witch flounder GC3.8) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=1 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=1 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=2 ?g/ml), Escherichia coli CGSC 4908 (MIC=1 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02366 GWKKWFTKGERLSQRHFA 18 "Pleurocidin-like peptide GC3.2 (NRC-18; fish, chordates, animals; Predicted)" Q7SZG7 Not found ple Glyptocephalus cynoglossus (Witch flounder GC3.2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC=128 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=32 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), E. coli UB1005 (MIC=64 ?g/ml), E. coli DC2 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02367 FLGLLFHGVHHVGKWIHGLIHGHH 24 "Pleurocidin-like peptide Hb26 (NRC-19; fish, chordates, animals; Predicted)" Q7SZG6 Not found ple Hippoglossus hippoglossus (Halibut Hb26) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), E. coli UB1005 (MIC=16 ?g/ml), E. coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=8 ?g/ml).##Yeast: Candida albicans C627 (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02368 GFLGILFHGVHHGRKKALHMNSERRS 26 "Pleurocidin-like peptide Hb18 (NRC-20; fish, chordates, animals; Predicted)" Q7SZG5 Not found ple Hippoglossus hippoglossus (Halibut Hb18) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC>64 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC 4908 (MIC>64 ?g/ml), E. coli UB1005 (MIC>64 ?g/ml), E. coli DC2 (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02374 GCRFCCNCCPNMSGCGVCCRF 21 "Bass hepcidin (fish, chordates, animals)" P82951 Belongs to the hepcidin family hamp Morone chrysops x Morone saxatilis (white bass x striped sea-bass) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Beta strand (2 strands; 6 residues) "Solution structure by NMR indicates that bass hepcidin is very similar to that of human hepcidin, including the presence of an antiparallel beta-sheet, a conserved disulfide-bonding pattern, and a rare vicinal disulfide bond." 1S6W resolved by NMR. "Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity). Synthetic bass hepcidin is active in vitro against Gram-negative pathogens and fungi but showes no activity against key Gram-positive pathogens and a single yeast strain tested. Tissue specificity: Predominantly expressed in liver. Induction: By bacterial challenge. PTM: Contains four disulfide bonds 2-19; 5-8; 6-15; 9-18." "Gram-negative bacteria: Escherichia coli ATCC 25,922,351,50 (MIC=22 ?M), Escherichia coli ATCC D31K (MIC=11 ?M), Klebsiella pneumoniae ATCC 10,031 (MIC=22 ?M), P. shigelloides ATCC KST (MIC=11 ?M), S. flexneri ATCC 12,022 (MIC=22 ?M), Shigella sonnei ATCC 9290 (MIC=44 ?M), Y. enterocolitica ATCC 23,715 (MIC=22 ?M).##Fungi: Aspergillus niger (MIC=44 ?M)." [Ref.15546886] It displays essentially no hemolytic activity toward HSB erythrocytes Cyclic Free Free "Disulfide bonds between Cys2 and Cys19; Cys5 and Cys8; Cys6 and Cys15,Cys9 and Cys18." L No cytotoxicity information found Not found 11985602##15546886 Eur J Biochem. 2002 Apr;269(8):2232-2237.##J Biol Chem. 2005 Mar 11;280(10):9272-9282. "Shike H, Lauth X, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Shimizu C, Bulet P, Burns JC.##Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME." "Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge.##Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections." DRAMP02376 LFGFLIKLIPSLFGALSNIGRNRNQ 25 "Grammistin Gs 1 (Grammistin Gs F; Group I grammistin; soapfish, chordates, animals)" P69835 Belongs to the grammistin family (Group 1 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=12.5 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=12.5 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Fish. Sci. 2001 Oct;67:928-933. "Yokota H, Nagashima Y, Shiomi K." Interaction of grammistins with lipids and their antibacterial activity. DRAMP02377 LFGFLIPLLPHIIGAIPQVIGAIR 24 "Grammistin Gs 2 (Grammistin Gs G; Group I grammistin; soapfish, chordates, animals)" P69836 Belongs to the grammistin family (Group 1 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=12.5 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), Photobacterium damselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=25 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Fish. Sci. 2001 Oct;67:928-933. "Yokota H, Nagashima Y, Shiomi K." Interaction of grammistins with lipids and their antibacterial activity. DRAMP02378 WWRELLKKLAFTAAGHLGSVLAAKQSGW 28 "Grammistin Gs A (Group III grammistin; soapfish, chordates, animals)" P69845 Belongs to the grammistin family (Group 3 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=50 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=25 ?g/ml), Salmonella typhimurium S1 (MIC>50 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=50 ?g/ml), Vibrio parahaemolyticus (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15777955 Toxicon. 2005 Apr;45(5):595-601. "Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K." Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus. DRAMP02379 IGGIISFFKRLF 12 "Grammistin Gs B (Group II grammistin; soapfish, chordates, animals)" P69839 Belongs to the grammistin family (Group 2 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=12.5 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC=12.5 ?g/ml), S. putrefaciens IAM 1509 (MIC=3.13 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=6.25 ?g/ml), Vibrio parahaemolyticus (MIC=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15777955 Toxicon. 2005 Apr;45(5):595-601. "Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K." Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus. DRAMP02380 NWRKILGKIAKVAAGLLGSMLAGYQV 26 "Grammistin Gs C (Group III grammistin; soapfish, chordates, animals)" P69846 Belongs to the grammistin family (Group 3 subfamily) Not found Grammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "MOA: Thanks to its amphiphilic alpha-helice(s), it may integrate into membrane phospholipids, leading to lysis of the membrane." "Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 ?g/ml), Staphylococcus aureus IAM 1011 (MIC=12.5 ?g/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 ?g/ml), Escherichia coli JCM 1649 (MIC=12.5 ?g/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 ?g/ml), Salmonella typhimurium S1 (MIC=12.5 ?g/ml), S. putrefaciens IAM 1509 (MIC=6.25 ?g/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 ?g/ml), Vibrio parahaemolyticus (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15777955 Toxicon. 2005 Apr;45(5):595-601. "Sugiyama N, Araki M, Ishida M, Nagashima Y, Shiomi K." Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus. DRAMP18375 GLDFSQPFPSGEFAVCESCKLGRGKCRKECLENEKPDGNCRLNFLCCRQRI 51 hBD-5 (human beta-defensin 5) No entry found Belongs to the beta-defensin family. Not found Homo sapiens "Antimicrobial, Antibacterial" bridge Not found None "PTM: There are 7 cysteines, making it likely to form an intermolecular S-S bond." Active against E. coli K12. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12193721 J Immunol. 2002 Sep 1;169(5):2516-23. "Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y." Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. DRAMP18373 CMSYGGSCQRSCNGGFRLGGHCGHPKIRCCRRK 33 mBD-6 (Murine beta-defensin 6) No entry found Belongs to the beta-defensin family. Not found Mus musculus "Antimicrobial, Antibacterial, Anti-Gram-" bridge Not found None Comment: No comments found on DRAMP database Gram-negative bacteria: E. coli. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11408484 J Biol Chem. 2001 Aug 24;276(34):31510-4 "Yamaguchi Y, Fukuhara S, Nagase T, Tomita T, Hitomi S, Kimura S, Kurihara H, Ouchi Y." "A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle." DRAMP18374 FFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCCRTIQPSGSIID 45 hBD-6 (human beta-defensin 6) No entry found Belongs to the beta-defensin family. Not found Homo sapiens "Antimicrobial, Antibacterial, Anti-Gram-, Chemotactic" beta Not found 2LWL Comment: No comments found on DRAMP database Gram-negative bacteria: E. coli K12. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12193721 J Immunol. 2002 Sep 1;169(5):2516-23 "Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y." Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. DRAMP02386 KGRGKQGGKVRAKAKTRSS 19 "Parasin I (histone-H2A-derived; catfishes, chordates, animals)" No entry found Not found Not found Parasilurus asotus (Amur catfish) "Antimicrobial, Antibacterial" Not found Alpha helix Not found None Comment: No comments found on DRAMP database "Aeromonas salmonicida (MIC=10 ?g/ml), Cytophaga aquatilis (MIC=5 ?g/ml), Yersinia rukeri (MIC=15 ?g/ml), Edwardsiella ictaluri (MIC=10 ?g/ml), Lactococcus garvieae (MIC=10 ?g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 9824303 FEBS Lett 1998; 437: 258-262. "Park IY, Park CB, Kim MS, Kim SC." "Parasin I, an antimicrobial peptide derived from histon H2A in the catfish, Parasilurus asotus." DRAMP02390 RPRPNYRPRPIYRP 14 "Astacidin 2 (crayfish, Arthropods, animals)" Q0PJU7 Not found Not found Pacifastacus leniusculus (signal crayfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Rich Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Shigella flexneri ATCC 203 (MIC=0.98 ?g/ml), Proteus vulgaris OX19 ATCC 6380 (MIC=7.8 ?g/ml), Escherichia coli D21 (MIC=3.9 ?g/ml), Psedomonas aeruginosa OT 97 (MIC=7.8 ?g/ml).##Gram-positive bacteria: Bacillus megateriun B11 (MIC=1.9 ?g/ml), Bacillus subtilis ATCC 6633 (MIC=1.95 ?g/ml), Staphylococcus aureus JC-1 (MIC=7.8 ?g/ml), Micrococcus luteus Ml 11 (MIC=10 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17049601 Dev Comp Immunol. 2007;31(5):441-455. "Jiravanichpaisal P, Lee SY, Kim YA, Andrn T, S?derh?ll I." Antibacterial peptides in hemocytes and hematopoietic tissue from freshwater crayfish Pacifastacus leniusculus: characterization and expression pattern. DRAMP02391 GWFKKAWRKVKHAGRRVLDTAKGVGRHYLNNWLNRYRG 38 "Hematopoietic antimicrobial peptide-37 (MgCath37; hagfishes, chordates, animals)" Q71MD7 Not found CATH37 Myxine glutinosa (Atlantic hagfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Propionibacterium acnes ATCC 11827 and 33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081 and 13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771, 43935, 12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15019197 Peptides. 2003 Nov;24(11):1655-1667. "Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M." Hagfish intestinal antimicrobial peptides are ancient cathelicidins. DRAMP02393 GFFKKAWRKVKHAGRRVLDTAKGVGRHYVNNWLNRYRZ 38 "HFIAP-1 (HFIAP-2; hagfishes, chordates, animals)" No entry found Not found Not found Myxine glutinosa (Atlantic hagfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species. Sequence similarity: Sequences for HFIAP-1 and -2 are identical, but HFIAP-2 is brominated only at residue 7; they differ from MgCath37 by conservative replacements." "Gram-positive bacteria: Propionibacterium acnes ATCC 11827/33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081/13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771/43935/12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15019197 Peptides. 2003 Nov;24(11):1655-1667. "Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M." Hagfish intestinal antimicrobial peptides are ancient cathelicidins. DRAMP02394 GWFKKAWRKVKNAGRRVLKGVGIHYGVGLIZ 31 "HFIAP-3 (hagfishes, chordates, animals)" No entry found Not found Not found Myxine glutinosa (Atlantic hagfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species. HFIAP-1 and HFIAP-3 exhibit similar inhibitory activity. "Gram-positive bacteria: Propionibacterium acnes ATCC 11827/33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081/13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771/43935/12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15019197 Peptides. 2003 Nov;24(11):1655-1667. "Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M." Hagfish intestinal antimicrobial peptides are ancient cathelicidins. DRAMP02395 AACSDRAHGHICESFKSFCKDSGRNGVKLRANCKKTCGLC 40 "Aurelin (jellyfish, chordates, animals)" "Q0MWV8, P84891" Belongs to ShKT domain family Not found Aurelia aurita (Moon jellyfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Combine helix and strand structure Not found 2LG4 resolved by NMR. "Function: Antimicrobial peptide exhibits activity against Gram-positive and Gram-negative bacteria. Domian: Contains 1 ShKT domain. PTM: Contains three disulfide bonds (By similarity)." Gram-positive bacterium: Listeria monocytogenes EGD (MIC=22.64 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35p (MIC=7.66 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys19 and Cys40) Disulfide bonds between Cys3 and Cys33; Cys12 and Cys37; Cys19 and Cys40. L No cytotoxicity information found Not found 16890198##PubMed ID is not available Biochem Biophys Res Commun. 2006 Sep 22;348(2):514-523.##To be Published. "Ovchinnikova TV, Balandin SV, Aleshina GM, Tagaev AA, Leonova YF, Krasnodembsky ED, Men'shenin AV, Kokryakov VN.##Shenkarev Z, Altukhov D, Gizatullina A, Arseniev A, Ovchinnikova T." "Aurelin, a novel antimicrobial peptide from jellyfish Aurelia aurita with structural features of defensins and channel-blocking toxins.##Solution structure of aurelin, a novel antimicrobial peptide." DRAMP02397 AVPDVAFNAYG 11 Big defensin (RPD-1) P86316 Belongs to the big defensin family Not found Venerupis philippinarum (Japanese carpet shell) (Tapes japonica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro. Has antibacterial activity. "Gram-positive bacteria: Staphylococcus aureus (MIC=9.6 mg/L), Bacillus subtilis (MIC=76.8 mg/L), Micrococcus tetragenus (MIC=38.4 mg/L);##Gram-negative bacteria: Escherichia coli (MIC=76.8 mg/L), Vibrio parahaemolyticus (MIC=19.2 mg/L), Vibrio anguillarum (MIC=19.2 mg/L)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14673509 Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Dec;35(12):1145-8. "Wei YX, Guo DS, Li RG, Chen HW, Chen PX." Purification of a big defensin from Ruditapes philippinesis and its antibacterial activity. DRAMP02402 FLPKMSTKLRVPYRRGTKDYH 21 Antimicrobial peptide scolopin-1 P0CH48 Not found Not found Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide against both Gram-positive, Gram-positive and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells. Tissue specificity: Expressed by the venom gland." "[Ref.19716842]Gram-negative bacteria: Escherichia coli standard strain (MIC=12.5 ?g/ml), E. coli drug-resistant strain (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=1.2 ?g/ml), S. aureus drug-resistant strain (MIC=5.0 ?g/ml), Bacillus dysenteriae standard and drug-resistant strains (MIC=7.5 ?g/ml);##Yeast: Candida albicans (MIC=15 ?g/ml)." [Ref.19716842]25 2% hemolytic activity at 50 g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19716842 Toxicon. 2010 Feb-Mar;55(2-3):274-279. "Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H." Two novel antimicrobial peptides from centipede venoms. DRAMP02403 GILKKFMLHRGTKVYKMRTLSKRSH 25 Antimicrobial peptide scolopin-2 P0CH49 Not found Not found Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide against both Gram-positive, -negative and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells. Tissue specificity: Expressed by the venom gland." "[Ref.19716842]Gram-negative bacteria: Escherichia coli standard and drug-resistant strains (MIC=5.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=0.5 ?g/ml), S. aureus drug-resistant strain (MIC=1.0 ?g/ml), Bacillus dysenteriae standard strain (MIC=2.5 ?g/ml), B. dysenteriae drug-resistant strain (MIC=5.0 ?g/ml);##Yeast: Candida albicans (MIC=7.5 ?g/ml)." [Ref.19716842]32 7% hemolytic activity at 50 g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19716842 Toxicon. 2010 Feb-Mar;55(2-3):274-279. "Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H." Two novel antimicrobial peptides from centipede venoms. DRAMP02409 GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF 34 M-theraphotoxin-Gr1a (M-TRTX-Gr1a; GsMTx-4) "Q7YT39, Q7M3T1" Belongs to the huwentoxin-1 family Not found Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Beta strand (5 strands; 9 residues) Not found "1LU8, 1TYK resolved by NMR." "Function: This cationic hydrophobic peptide inhibits a lot of different channels and has an antimicrobial activity. It blocks mechanosensitive ion channels (also named stretch-activated channels or SACs), without having effect on whole-cell voltage-sensitive currents. Acts by partitioning into the membrane and perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. Inhibits atrial fibrillation as well as the membrane motor of outer hair cells at low doses. GsMTx-4 exhibites antimicrobial properties and was more active against Gram-positive than Gram-negative bacteria. Tissue specificity: Expressed by the venom gland. Miscellaneous: This toxin does not inhibit potassium channels Kv1.1/KCNA1 (IC50>85 ?M), Kv1.4/KCNA4 (IC50>85 ?M) and Kv11.3/KCNH7 (IC50=53 ?M). PTM: Contains three disulfide bonds." "Gram-positive bacteria: Bacillus subtilis (MIC=0.5 ?M), Staphylococcus aureus (MIC=2-4 ?M), Staphylococcus epidermidis (MIC=4-8 ?M);##Gram-negative bacteria: Salmonella typhimurium (MIC=32.64 ?M), Pseudomonas aeruginosa (MIC=8-16 ?M), Escherichia coli (MIC=8-16 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys17,Cys9 and Cys23,Cys16 and Cys30." L No cytotoxicity information found Not found PubMed ID is not available##12082099##10779316##163768 Submitted (MAY-2002) to the PDB data bank##J Biol Chem. 2002 Sep 13;277(37):34443-50.##J Gen Physiol. 2000 May;115(5):583-598.##Biochem Biophys Res Commun. 2006 Feb 10;340(2):633-638. "Jung HJ, Lee CW, Earm YE, Kim JI.##Oswald RE, Suchyna TM, McFeeters R, Gottlieb P, Sachs F.##Suchyna TM, Johnson JH, Hamer K, Leykam JF, Gage DA, Clemo HF, Baumgarten CM, Sachs F.##Jung HJ, Kim PI, Lee SK, Lee CW, Eu YJ, Lee DG, Earm YE, Kim JI." "Solution structure of GsMTx-4, a peptide blocker of cation-selective stretch-activated channels.##Solution structure of peptide toxins that block mechanosensitive ion channels.##Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.##Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel." DRAMP02410 FSKYERQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIKWNEEGLPIYEIPGEGGHAEPAAA 62 Antimicrobial peptide lumbricin-1 O96447 Not found Not found Lumbricus rubellus (Humus earthworm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Displays antimicrobial activity and weak hemolytic activity. Developmental stage: Adult-specific. Not detected in eggs or 1-week-old worms but abundant in 6-month-old worms. Induction: Constitutively expressed. Not induced by bacterial infection." "[Ref.9784609]Gram-positive bacteria: Bacillus subtilis ATCC 62037 (MIC=12 ?g/ml), Staphylococcus aureus ATCC 15752 (MIC=16 ?g/ml), Streptococcus mutans ATCC 25175 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 27325 (MIC=12 ?g/ml), Pseudomonas putidaATCC 17426 (MIC=16 ?g/ml), Serratia sp. ATCC 21074 (MIC=16 ?g/ml);##Fungi: Candida albicans ATCC 10231 (MIC=16 ?g/ml), Cryptococcus neoformance ATCC 34881 (MIC=25 ?g/ml), Saccharomyces cerevisiae ATCC 44774 (MIC=12 ?g/ml).##NOTE: Minimal inhibitory concentrations were determined by incubating approximately 104C105 CFU/ml of cells with serial dilutions of each peptide in a 96-well microtiter plate." "[Ref.9784609]0.02% hemolytic activity at 5 g/ml, 0.06% hemolytic activity at 10 g/ml, 0.14% hemolytic activity at 25 g/ml, 0.19% hemolytic activity at 50 g/ml, 0.23% hemolytic activity at 100 g/ml against human erythrocytes " Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784609 Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76. "Cho JH, Park CB, Yoon YG, Kim SC." "Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization." DRAMP02411 GHLGRPYIGGGGGFNRGGGFHRGGGFHRGGGFHSGGGFHRGGGFHSGGSFGYR 53 Armadillidin (Glyc-rich) Q64HC7 Not found Not found Armadillidium vulgare (Pillbug) (Pill woodlouse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial activity against the Gram-positive bacterium B. megaterium LM101. Tissue specificity: Expressed in hemocytes and at very low levels in ovary. Not expressed in adipose tissue, brain, caecum, gut, heart and nervous chain. PTM C-terminal amidation." "Gram-positive bacteria: Bacillus megaterium LM101 (MIC=0.5-1.25 ?M), Enterococcus faecalis LM002, Micrococcus luteus LM610, Listeria ivanovii BUG496;##Gram-negative bacteria: Escherichia coli JM83, Salmonella thyphimurium LM122, Enterobacter cloacae LM111, Citrobacter freundii LM457.##NOTE: Because of the low amount of the purified peptide, this minimal concentration activity is only tested on B. megaterium." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15752546 Dev Comp Immunol. 2005;29(6):489-499. "Herbinire J, Braquart-Varnier C, Grve P, Strub JM, Frre J, Van Dorsselaer A, Martin G." "Armadillidin: a novel glycine-rich antibacterial peptide directed against Gram-positive bacteria in the woodlouse Armadillidium vulgare (terrestrial isopod, crustacean)." DRAMP02412 SYVGDCGSNGGSCVSSYCPYGNRLNYFCPLGRTCCRHAYV 40 "Panusin (Defensin-like peptide 7, PaD7) " F6KSI8 Belongs to the beta-defensin family Not found Panulirus argus (Caribbean spiny lobster) (Palinurus argus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Antimicrobial peptide. Has antibacterial activity. PTM: Contains two disulfide bonds (By similarity)." Gram-positive bacterium: Staphylococcus aureus ATCC 29737 (MIC=3.46 ?M);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=4.8 ?M). [Ref.27616720] It shows no hemolytic effect on human red blood cells Cyclic Free Free "Disulfide bonds between Cys6 and Cys28,Cys13 and Cys34,Cys18 and Cys35." L No cytotoxicity information found Not found 22885029##PubMed ID is not available Fish Shellfish Immunol. 2012 Oct;33(4):872-879.##Submitted (FEB-2012) to UniProtKB "Montero-Alejo V, Acosta-Alba J, Perdomo-Morales R, Perera E, Hernndez-Rodrguez EW, Estrada MP, Porto-Verdecia M.##Montero-Alejo V, Pacios-Michelena A, Perdomo-Morales R, Crozo G, Vega-Hurtado Y." "Defensin like peptide from Panulirus argus relates structurally with beta defensin from vertebrates.##Panusin, a new defensin-like antimicrobial peptide from the hemocytes of spiny lobster Panulirus argus." DRAMP02419 YENPYGCPTDEGKCFDRCNDSEFEGGYCGGSYRATCVCYRT 41 "Amblyomma defensin peptide 2 (ADP-2; Ticks, Arthropods, animals)" No entry found Not found Not found Amblyomma hebraeum (Tick) "Antimicrobial, Antibacterial" Not found Not found Not found None Comment: No comments found on DRAMP database Escherichia coli (MIC=30 ?M) and Staphylococcus aureus (MIC=7.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Has three disulfide bonds l No cytotoxicity information found Not found 14705963 Biochem J. 2004 May 1;379(Pt 3):681-685. "Lai R, Lomas LO, Jonczy J, Turner PC, Rees HH." "Two novel non-cationic defensin-like antimicrobial peptides from haemolymph of the female tick, Amblyomma hebraeum." DRAMP02421 ACHAHCQSVGRRGGYCGNFRMTCYCY 26 "Hlgut-defensin (H. longicornis midgut defensin; Ticks, Arthropods, animals)" A4GUC3 Not found Not found Haemaphysalis longicornis (Bush tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Not found Not found None "Function: Both Hlgut-defensin and Hlsal-defensin sequences have antibactrrial activity against a variety of Gram-positive and Gram-negative bacteria. Induction: By a lipopolysaccharide (LPS) injection." Gram-positive bacterium: Staphylococcus aureus (MIC=5-25 mg/mL);##Gram-negative bacterium: Escherichia coli (MIC=10-25 mg/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17521774 Peptides. 2007 Jun;28(6):1304-1310. "Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K." Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis. DRAMP02422 NCIQQCVSKGAQGGYCTNEKCTCY 24 "Hlsal-defensin (H. longicornis salivary gland defensin; Ticks, Arthropods, animals)" A4GUC4 Not found Not found Haemaphysalis longicornis (Bush tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Not found Not found None "Function: Both Hlgut-defensin and Hlsal-defensin sequences have antibactrrial activity against a variety of Gram-positive and Gram-negative bacteria. Induction: By a lipopolysaccharide (LPS) injection." Gram-positive bacterium: Staphylococcus aureus (MIC=5-25 mg/mL);##Gram-negative bacterium: Escherichia coli (MIC=10-25 mg/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17521774 Peptides. 2007 Jun;28(6):1304-1310. "Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K." Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis. DRAMP02423 DFGCARGMIFVCMRRCARMYPGSTGYCQGFRCMCDTMIPIRRPPFIMG 48 "HlMS-defensin (Ticks, Arthropods, animals)" No entry found Not found Not found Haemaphysalis longicornis (Tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=18.8 ?g/ml), Bacillus licheniformis (MIC=9.4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=28.1 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=37.5 ?g/ml), Serratia rubidaea (MIC=28.1 ?g/ml), Psychrobacter faecalis (MIC=2.3 ?g/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22033149 Dev Comp Immunol. 2012 May;37(1):207-211. "Zheng H, Zhou L, Yang X, Wang D, Liu J." Cloning and characterization of a male-specific defensin-like antimicrobial peptide from the tick Haemaphysalis longicornis. DRAMP02425 QLKVDLWGTRSGIQPEQHSSGKSDVRRWRSRY 32 "Ixosin-B (Ticks, Arthropods, animals)" A7UDM9 Not found Not found Ixodes sinensis (Hard tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antifungal and antibacterial activity. Ixosin-B has little hemolytic activity on red blood cells even with peptide concentrations up to 200 ?g/mL." [Ref.18295522]Gram-positive bacterium: Staphylococcus aureus (MIC=2.5 ?g/mL);##Gram-negative bacterium: Escherichia coli (MIC=15 ?g/mL);##Yeast: Candida albicans (MIC=7.5 ?g/mL). [Ref.18295522]Little hemolytic activity on rabbit red blood cells up to 200 g/mL Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18295522 Comp Biochem Physiol B Biochem Mol Biol. 2008 Apr;149(4):557-561. "Liu Z, Liu H, Liu X, Wu X." "Purification and cloning of a novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis." DRAMP02427 GGYYCPFFQDKCHRHCRSFGRKAGYCGGFLKKTCICV 37 "Ixodes ricinus defensin def1 (Ticks, Arthropods, animals)" No entry found Not found def1 Ixodes ricinus (European tick) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Bridge Not found None Function: Has antibacterial activity against Gram-positive bacteria. "Gram-positive bacteria: Bacillus subtilis (MIC=1.5 ?M), Micrococcus luteus(MIC=0.75 ?M), Staphylococcus aureus (MRSA) (MIC=50 ?M)." [Ref.21504572] It has 2.9% and 75% hemolysis at concentrations of 12.5 M and 100 M against human erythrocytes . Cyclic Free Free "Disulfide bonds between Cys5 and Cys26,Cys12 and Cys34,Cys16 and Cys36." L No cytotoxicity information found Not found 21504572 Parasit Vectors. 2011 Apr 19;4(1):63. "Chrudimska T, Slaninova J, Ruzek D, Rudenko N, Grubhoffer L." Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus. DRAMP02428 GGYYCPFRQDKCHRHCRSFGRKAGYCGGFLKKTCICV 37 "Ixodes ricinus defensin def2 (Ticks, Arthropods, animals)" No entry found Not found def2 Ixodes ricinus (European tick) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Bridge Not found None Function: Has antibacterial activity against Gram-positive bacteria. "Gram-positive bacteria: Bacillus subtilis (MIC=0.75 ?M), Micrococcus luteus(MIC=0.37 ?M), Staphylococcus aureus (MRSA) (MIC=25 ?M)." [Ref.21504572] It has 2.0% and 64.6% hemolysis at concentrations of 12.5 M and 100 M against human erythrocytes . Cyclic Free Free "Disulfide bonds between Cys5 and Cys26,Cys12 and Cys34,Cys16 and Cys36." L No cytotoxicity information found Not found 21504572 Parasit Vectors. 2011 Apr 19;4(1):63. "Chrudimska T, Slaninova J, Ruzek D, Rudenko N, Grubhoffer L." Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus. DRAMP02429 QRGSRGQRCGPGEVFNQCGSACPRVCGRPPAQACTLQCVSGCFCRRGYIRTQRGGCIPERQCHQR 65 "Chymotrypsin-elastase inhibitor ixodidin (Ticks, Arthropods, animals)" P83516 Not found Not found Boophilus microplus (Cattle tick) "Antimicrobial, Antibacterial" Protein level Not found Not found None "Function: Inhibits chymotrypsin and elastase. Has antibacterial activity against Gram-positive bacterium M.luteus and the Gram-negative bacterium E. coli. PTM: Contains five disulfide bonds." "Escherichia coli (20% inhibition at 1mM), Micrococcus luteus(MIC=0.12-0.24 mM)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic pyroglutamic acid Free "Disulfide bonds between Cys9 and Cys34,Cys18 and Cys42,Cys22 and Cys38,Cys26 and Cys62,Cys44 and Cys56." L No cytotoxicity information found Not found 16191451 Peptides. 2006 Apr;27(4):667-74. "Foga?a AC, Almeida IC, Eberlin MN, Tanaka AS, Bulet P, Daffre S." "Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases." DRAMP02430 GLHKVMREVLGYERNSYKKFFLR 23 "Ixosin (Ticks, Arthropods, animals)" Q2LKX9 Not found Not found Ixodes sinensis (Hard tick) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antifungal activity against C. albicans. Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Little hemolytic activity against rabbit erythrocytes. [Ref.16087274]Gram-postive bacteria: Staphylococcus aureus (MIC=3.7 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=30 ?g/ml);##Fungi: Candida albicans (MIC=7.5 ?g/ml). [Ref.16087274]Little hemolytic activity on rabbit red blood cells up to 50 g/mL Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16087274 Peptides. 2006 Jan;27(1):31-5. "Yu D, Sheng Z, Xu X, Li J, Yang H, Liu Z, Rees HH, Lai R." "A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis." DRAMP02432 PDPGQPWQVKAGRPPCYSIPCRKHDECRVGSCSRCNNGLWGDRTCR 46 "Antimicrobial peptide ISAMP (Ticks, Arthropods, animals)" Q8MVA6 Not found Not found Ixodes scapularis (Black-legged tick) (Deer tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial activity and weak hemolytic. Tissue specificity: Expressed in the fat body, hemocytes and salivary glands of partially-fed female ticks. Not expressed in the midgut." "[Ref.19852941]Gram-positive bacteria: Bacillus cereus (MIC=5.8 ?g/ml), Bacillus subtilis (MIC=12.3 ?g/ml), Staphylococcus aureus (MIC=10.4 ?g/ml);##Gram-negative bacteria: Escherichia coli Edl 933 (MIC=3.2 ?g/ml), E. coli MG/655 (MIC=4.2 ?g/ml)." [Ref.19852941]Insignificant hemolytic activity even up to 150 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12177149##19852941 J Exp Biol. 2002 Sep;205(Pt 18):2843-2864.##Biochem Biophys Res Commun. 2009 Dec 18;390(3):511-515. "Valenzuela JG, Francischetti IM, Pham VM, Garfield MK, Mather TN, Ribeiro JM.##Pichu S, Ribeiro JM, Mather TN." "Exploring the sialome of the tick Ixodes scapularis.##Purification and characterization of a novel salivary antimicrobial peptide from the tick, Ixodes scapularis." DRAMP02433 HHQELCTKGDDALVTELECIRLRISPETNAAFDNAVQQLNCLNRACAYRKMCATNNLEQAMSVYFTNEQIKEIHDAATACDPEAHHEHDH 90 "Antimicrobial peptide microplusin (Microplusin; Ticks, Arthropods, animals)" Q86LE5 Not found Not found Boophilus microplus (Cattle tick) "Antimicrobial, Antifungal, Antibacterial" Protein level Alpha helix "Microplusin consists of five alpha-helices: alpha1 (residues Gly-9 to Arg-21), alpha2 (residues Glu-27 to Asn-40), alpha3 (residues Arg-44 to Thr-54), alpha4 (residues Leu-57 to Tyr-64), and alpha5 (residues Asn-67 to Cys-80). The N and C termini are disordered." 2KNJ?resolved by NMR. "Function: Has bacteriostatic activity against the Gram-positive bacterium M.luteus. Has fungistatic activity against C.neoformans. Binds and sequesters copper and iron ions. Copper-chelating is crucial for antimicrobial activity against M.luteus. Tissue specificity: Expressed in the hemocytes, fat body and ovaries. PTM: Contains three disulfide bonds 6-52; 19-80; 41-46." "Micrococcus luteus (MIC=0.38-0.76 ?M), Cryptococcus neoformans." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys6 and Cys52,Cys19 and Cys80,Cys41 and Cys46." L No cytotoxicity information found Metal-binding: copper II and iron II 14642886##19828445 Dev Comp Immunol. 2004 Mar;28(3):191-200.##J Biol Chem. 2009 Dec 11;284(50):34735-34746. "Foga?a AC, Lorenzini DM, Kaku LM, Esteves E, Bulet P, Daffre S.##Silva FD, Rezende CA, Rossi DC, Esteves E, Dyszy FH, Schreier S, Gueiros-Filho F, Campos CB, Pires JR, Daffre S." "Cysteine-rich antimicrobial peptides of the cattle tick Boophilus microplus: isolation, structural characterization and tissue expression profile.##Structure and mode of action of microplusin, a copper II-chelating antimicrobial peptide from the cattle tick Rhipicephalus (Boophilus) microplus." DRAMP02434 FSRYARMRDSRPWSDRKNNYSGPQFTYPPEKAPPEKLIKWNNEGSPIFEMPAEGGHIEP 59 Antimicrobial peptide lumbricin-PG (Lumbricin-PG) P86929 Not found Not found Pheretima guillelmi (Earthworm) (Metaphire guillelmi) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Displays stronger activity against P. aeruginosa and S. aureus than E. coli. At the concentration of 200 g/ml, it induces 1.5 and 2.1% hemolysis of human and rabbit red blood cells, respectively." "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=2.5 ?g/m).##Fungi: Candida albicans ATCC 2002." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21539875 Peptides. 2011 Jun;32(6):1146-1150. "Li W, Li S, Zhong J, Zhu Z, Liu J, Wang W." "A novel antimicrobial peptide from skin secretions of the earthworm, Pheretima guillelmi (Michaelsen)." DRAMP02445 LYKLVKVVLNM 11 Antimicrobial protein BL-A60 B3EWC5 Not found Not found Brevibacillus laterosporus (Bacillus laterosporus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. In P.capsici, inhibits mycelial growth (EC50=7.89 ?g/ml), formation of sporangia (EC50=0.6 ?g/ml) and cytospore germination (EC50=21.96 ?g/ml). PTM: Contains a choline moiety at the N-terminus and a tenuazonic acid moiety at the C-terminus. Biophysicochemical properties: pH dependence (Active between pH 3 and 11); Temperature dependence (Retains >80% activity after 15 min at 100 degrees Celsius)." "Gram-negative bacterium: Pseudomonas solanacearum (MIC=10 ?M);##Gram-positive bacterium: Bacillus subtilis (MIC=5 ?M).##Fungi: Phytophthora capsici (MIC=15 ?M), Botrytis cinerea (MIC=25 ?M), Verticillium dahliae (MIC=200 ?M), Fusarium oxysporum (MIC=50 ?M), Xerocomus vesicolor (MIC=100 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22244810 Peptides. 2012 Feb;33(2):206-211. "Zhao J, Guo L, Zeng H, Yang X, Yuan J, Shi H, Xiong Y, Chen M, Han L, Qiu D." Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60. DRAMP02446 YSKSLPLSVLNP 12 Antimicrobial protein 1 (Antimicrobial protein AN5-1) B3EWQ6 Not found Not found Paenibacillus alvei (Bacillus alvei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has a broad inhibitory spectrum against both Gram-positive and -negative bacterial strains. Miscellaneous: A synthetic peptide has no antibacterial activity against S. agalactiae ATCC 12386, S. epidermidis, P. aeruginosa and methicillin-resistant S. aureus (MRSA). Biophysicochemical properties: pH dependence (Active between pH 2 and 12); Temperature dependence (Active between 37 and 90 degrees Celsius. Activity is reduced at 100 degrees Celsius and absent at 110 degrees Celsius. Activity is unaffected by storage at -20 degrees Celsius)." "Gram-positive bacteria: Lactobacillus plantarum strain ATCC 8014 (MIC=32 ?g/ml), Lactococcus lactis ATCC 11454 (MIC>128 ?g/ml), Bacillus cereus strain ATCC 14579 (MIC=64 ?g/ml), Staphylococcus aureus (MIC=64 ?g/ml), Bacillus subtilis (MIC=32 ?g/ml), Bacillus anthracis (MIC=128 ?g/ml) and Bacillus licheniformis (MIC>128 ?g/ml), Bacillus ?exus (MIC=32 ?g/ml);##Gram-negative bacteria: Escherichia coli strain ATCC 13076 (MIC=8 ?g/ml), Salmonella enteritidis ATCC 13076 (MIC=4 ?g/ml), Enterobacter spp. (MIC=16 ?g/ml), Serratia marcescens (MIC=32 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23508455 J Ind Microbiol Biotechnol. 2013 Jun;40(6):571-579. "Alkotaini B, Anuar N, Kadhum AA, Sani AA." Detection of secreted antimicrobial peptides isolated from cell-free culture supernatant of Paenibacillus alvei AN5. DRAMP02456 DGVCSNRRQCNKEVCGSSYDVAIVGA 26 L-amino-acid oxidase (LAAO; LAO; Dactylomelin-P) P86163 Belongs to the flavin monoamine oxidase family Not found Aplysia dactylomela (Spotted sea hare) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Catalyzes the oxidative deamination of positively charged L-amino acids L-Lys and L-Arg but not of amino acids L-His, L-Asp or L-Glu. Has antibacterial activity. This antibacterial activity is bacteriostatic in the absence of amino acids L-Lys or L-Arg but bactericidal in their presence. The antibacterial effect is largely dependent on H2O2 produced in the oxidative deamination of substrates. Has hemagglutinating activity towards rabbit erythrocytes. Hemagglutinating activity is inhibited by the glycoprotein fetuin, but not by glucose, mannose, galactose, N-acetylglucosamine, N-acetylgalactosamine or sialic acid. Tissue specificity: Expressed by the ink gland. Biophysicochemical properties: Kinetic parameters (KM=0.22 mM for L-Lys; KM=0.015 mM for L-Arg); pH dependence (Optimum pH is 8. More than 50% activity is retained between pH 3 and 12. Inactive at pH 2); Temperature dependence (Activity remains stable after 30 min at 55 degrees Celsius)." Gram-positive bacterium: S. aureus (MIC=15 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10758276 Toxicon. 2000 Oct;38(10):1415-1427. "Melo VM, Duarte AB, Carvalho AF, Siebra EA, Vasconcelos IM." "Purification of a novel antibacterial and haemagglutinating protein from the purple gland of the sea hare, Aplysia dactylomela rang, 1828." DRAMP02470 SCTTCECCCSCS 12 Nosiheptide (NOS; Antibiotic 9671-RP) C6FX52 Belongs to the thiocillin family nosM Streptomyces actuosus "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Inhibits bacterial protein biosynthesis by binding to ribosomes. Specifically, binds to the complex of 23S rRNA and ribosomal protein L11 (RPLK) in the 50S ribosomal subunit. While allowing a weak binding of elongation factor G (EF-G) to the ribosome and subsequent GTP-hydrolysis, probably impairs conformational changes in both the ribosome and EF-G which are necessary for translocation. In vitro, inhibits a variety of Gram-positive bacteria and inhibits Gram-negative bacterium P. multocida strain A125 (MIC=0.0024 ?g/ml). Does not inhibit Gram-negative bacterium E. coli strain ATCC 9637 but does inhibit purified ribosomes from E. coli. In vivo, has no systemic effect in mice infected with staphylococci or streptococci when applied orally or subcutaneously. Has a local effect in mice infected subcutaneously or intraperitoneally with staphylococci when applied immediately afterwards. Is not toxic to mice. Miscellaneous: The mature peptide is identical to multhiomycin from S. antibioticus strain 8446CC1 (PMID 681244). Used as an antibiotic growth promotant in poultry and pig farming in parts of Asia." "Gram-positive bacteria: Staphylococcus aureus strain 209P (MIC=0.0009 ?g/ml), S. aureus strain 133 (MIC=0.0019 ?g/ml), S. aureus strain B3 (MIC=0.003 ?g/ml), S. aureus strain Hb (MIC=0.003 ?g/ml), Micrococcus citreus strain ATCC 8411 (MIC=0.0038 ?g/ml), M. lysodeikticus strain ATCC 4698 (MIC=0.003 ?g/ml), Sarcina Lutea strain ATCC 9341 (MIC=0.0011 ?g/ml), Streptococcus faecalis strain ATCC 9790 (MIC=0.0007 ?g/ml), S. viridans (MIC=0.0065 ?g/ml), Streptococcus pyogenes hemolyticus strain Dig7 (MIC=0.00028 ?g/ml), Diplococcus pneumoniae strain Til (MIC=0.00015 ?g/ml), N. catrrhalis (MIC=0.0017 ?g/ml), Lactobacillus casei strain ATCC 6633 (MIC=0.003 ?g/ml), Bacillus cereus ATCC 6630 (MIC=0.0071 ?g/ml) and various isolates of Listeria monocytogenes.##Gram-negative bacterium: P. multocida strain A125 (MIC=0.0024 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19678698##18406324 ACS Chem Biol. 2009 Oct 16;4(10):855-864.##Mol Cell. 2008 Apr 11;30(1):26-38. "Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W.##Harms JM, Wilson DN, Schluenzen F, Connell SR, Stachelhaus T, Zaborowska Z, Spahn CM, Fucini P." Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.##Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. DRAMP02473 KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF 30 "Cathelicidin-BF (Cathelicidin-related protein; Snakes, reptiles, animals)" B6D434 Not found Not found Bungarus fasciatus (Banded krait) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane. No hemolytic and cytotoxic activities have been observed on mammalian cells. Tissue specificity: Expressed by the venom gland, stomach, trachea, skin, muscle, heart, kidney, lung, brain, intestine, spleen, liver, and ovary. Miscellaneous: A predicted cleavage site is located at position Val-157-158-Lys, giving a peptide of 34 residues instead of the 30 residues found for the purified protein. The 30 residues cathelicidin-BF could result from a further processing." "[Ref.18795096]Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=1.2 ?g/ml), P. aeruginosa IS/DR (MIC=2.3 ?g/ml), P. aeruginosa 08031205 IS/DR (MIC=9.4 ?g/ml), P. aeruginosa 08031014 IS/DR (MIC=18.7 ?g/ml), Escherichia coli ATCC25922 (MIC=2.3 ?g/ml), E. coli 08A852 IS/DR (MIC=1.2 ?g/ml), E. coli 08A866 IS/DR (MIC=0.6 ?g/ml), E. coli 08031017 IS/DR (MIC=2.3 ?g/ml), E. coli 08032813 IS/DR (MIC=2.3 ?g/ml), E. coli 08040726 IS/DR (MIC=0.6 ?g/ml), E. coli 08040722 IS/DR (MIC=0.6 ?g/ml), Klebsiella pneumoniae IS/DR (MIC=4.7 ?g/ml), K. pneumoniae 08031012 IS/DR (MIC=9.4 ?g/ml), K. pneumoniae 08040202 IS/DR (MIC=0.6 ?g/ml), K. pneumoniae 08040724 IS/DR (MIC=0.3 ?g/ml), Pseudomonas luteola (MIC=1.2 ?g/ml), Salmonella Typhi IS/DR (MIC=1.2 ?g/ml), Acinetobacter calcoaceticus (MIC=2.3 ?g/ml), Sphingobacterium siyangense (MIC=9.4 ?g/ml), Saccharibacillus kuerlensis (MIC=4.7 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=9.4 ?g/ml), B. pumilus (MIC=9.4 ?g/ml), B. cereus (MIC=1.2 ?g/ml), Staphylococcus aureus ATCC2592 (MIC=4.7 ?g/ml), S. aureus 08A875 IS/DR (MIC=75 ?g/ml), S. aureus 08031002 IS/DR (MIC>100 ?g/ml), S. aureus 08031013 IS/DR (MIC>100 ?g/ml), S. aureus 08032706 IS/DR (MIC>100 ?g/ml), S. aureus 08032712 IS/DR (MIC>100 ?g/ml), S. aureus 08032810 IS/DR (MIC>100 ?g/ml), Enterococcus faecium IS/DR (MIC=150 ?g/ml);##Fungi: Aspergillus terreus GIM3.34 (MIC=18.7 ?g/ml), Aspergillus nidulans (MIC=18.7 ?g/ml), Candida albicans ATCC2002 (MIC=4.7 ?g/ml), Pichia pastoris (MIC=0.3 ?g/ml)." [Ref.18795096]Non-hemolytic activity at 400 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 18795096##18620012 PLoS One. 2008 Sep 16;3(9):e3217.##Peptides. 2008 Oct;29(10):1685-1691. "Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R.##Zhao H, Gan TX, Liu XD, Jin Y, Lee WH, Shen JH, Zhang Y." Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics.##Identification and characterization of novel reptile cathelicidins from elapid snakes. DRAMP02474 KFFRKLKKSVKKRAK 15 "cathelicidin-BF15 (Snakes, reptiles, animals)" B6D434 Not found Not found Bungarus fasciatus (Banded krait) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=4.7 ?g/ml), P. aeruginosa IS/DR (MIC=37.5 ?g/ml), P. aeruginosa 08031205 IS/DR (MIC=18.7 ?g/ml), P. aeruginosa 08031014 IS/DR (MIC=75 ?g/ml), Escherichia coli ATCC25922 (MIC=18.7 ?g/ml), E. coli 08A852 IS/DR (MIC=18.7 ?g/ml), E. coli 08A866 IS/DR (MIC=18.7 ?g/ml), E. coli 08031017 IS/DR (MIC=37.5 ?g/ml), E. coli 08040722 IS/DR (MIC=9.4 ?g/ml), K. pneumoniae 08040202 IS/DR (MIC=75 ?g/ml), Salmonella Typhi IS/DR (MIC=1.2 ?g/ml), Saccharibacillus kuerlensis (MIC=4.7 ?g/ml).##Gram-positive bacteria: Bacillus subtilis (MIC=75 ?g/ml), Staphylococcus aureus ATCC2592 (MIC=75 ?g/ml), S. aureus 08A875 IS/DR (MIC=75 ?g/ml), S. aureus 08031002 IS/DR (MIC>100 ?g/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.7 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18795096 PLoS One. 2008 Sep 16;3(9):e3217. "Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R." Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. DRAMP02478 IKFEPPLPPKKAHKKFWEDDGIYYPPNHNFP 31 "L-amino-acid oxidase (Bm-LAO; LAAO; LAO; Snakes, reptiles, animals)" B3EWI9 Belongs to the flavin monoamine oxidase family (FIG1 subfamily) Not found Bothropoides matogrossensis (Pitviper) (Bothrops neuwiedimatogrossensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic" Protein level Not found Not found None "Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). Tissue specificity: Expressed by the venom gland." "Gram-positive bacteria: Bacillus subtilis strain ATCC 6633 (MIC=32 ?M), Enterococcus faecalis strain ATCC 12953 (MIC=32 ?M), Staphylococcus aureus strain ATCC 29213 (MIC=32 ?M), Streptococcus pyogenes strain ATCC 19615 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli strain ATCC 8739 (MIC=4 ?M), Klebsiella pneumoniaee strain ATCC 13885 (MIC=2 ?M), Proteus mirabilis strain ATCC 25933 (MIC=2 ?M), Pseudomonas aeruginosa strain ATCC 15442 (MIC=8 ?M), Salmonella typhimurium strain ATCC 14028 (MIC=8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22438972 PLoS One. 2012;7(3):e33639. "Okubo BM, Silva ON, Migliolo L, Gomes DG, Porto WF, Batista CL, Ramos CS, Holanda HH, Dias SC, Franco OL, Moreno SE." Evaluation of an antimicrobial L-amino acid oxidase and peptide derivatives from Bothropoides mattogrosensis pitviper venom. DRAMP02520 KRFKKFFKKLKNSVKKRAKKFFKKPRVIGVSIPF 34 "OH-CATH (Snakes, reptiles, animals)" No entry found Not found Not found Ophiophagus hannah (King cobra) (Naja hannah) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 ?g/ml), E. coli ML-35P (MIC=6 ?g/ml), E. coli clinic strain (MIC=20 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?g/ml), Pseudomonas aeruginosa PA 01 (MIC=2 ?g/ml), Pseudomonas aeruginosa clinic strain (MIC=2 ?g/ml), Enterobacter aerogenes clinic strain (MIC=2 ?g/ml), E. cloacae clinic strain (MIC=1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18620012 Peptides. 2008 Oct;29(10):1685-1691. "Zhao H, Gan TX, Liu XD, Jin Y, Lee WH, Shen JH, Zhang Y." Identification and characterization of novel reptile cathelicidins from elapid snakes. DRAMP02522 HVINLEESFQEPEYENHLA 19 "L-amino-acid oxidase (LAAO, LAO, Oh-LAAO; Snakes, reptiles, animals)" "P81383, A8QL50" Not found Not found Ophiophagus hannah (King cobra) (Naja hannah) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: It binds to bacteria and shows antibacterial activities by generating hydrogen peroxide. Binding and antibacterial activities are higher against Gram-positive than against Gram-negative bacteria. May also have an ability to induce hemorrhage, hemolysis, edema, apoptosis. Tissue specificity: Expressed by the venom gland. Toxic dose: LD50 is 5 mg/kg by intravenous injection into mice. Temperature dependence: Exhibits unusual thermal stability. At pH 7.4, the enzyme retains full activity after incubation at 25 degrees Celsius for 30 days. Is stable at alkaline condition and is not inactivated by freezing." "Gram-negative bacteria: Klebsiella pneumonia (MIC=0.4 ?M), Pseudomonas aeruginosa (MIC=0.2 ?M), Escherichia coli (MIC=0.4 ?M), Escherichia coli ATCC 25922 (MIC=0.8 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=0.006 ?M), S. epidermidis (MIC=0.012 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Bacterial cell 9304806##2619759##2044840##7886693##21059402 Int J Biochem Cell Biol. 1997 Jun;29(6):911-919.##Biochem Int. 1989 Oct;19(4):937-944.##Int J Biochem. 1991;23(3):323-327.##Toxicon. 1994 Nov;32(11):1349-1358.##Comp Biochem Physiol C Toxicol Pharmacol. 2011 M "Ahn MY, Lee BM, Kim YS.##Tan NH, Saifuddin MN.##Tan NH, Saifuddin MN.##Li ZY, Yu TF, Lian EC.##Lee ML, Tan NH, Fung SY, Sekaran SD." Characterization and cytotoxicity of L-amino acid oxidase from the venom of king cobra (Ophiophagus hannah).##Isolation and characterization of an unusual form of L-amino acid oxidase from King cobra (Ophiophagus hannah) venom.##Substrate specificity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase.##Purification and characterization of L-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation.##Antibacterial action of a heat-stabl DRAMP02573 QVYKGGYTRPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS 62 "Penaeidin-3a (Pen-3a; shrimps, Arthropods, animals)" P81058 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity. Tissue specificity: Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain. Developmental stage: Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours. PTM: C-terminal amidation and contains three disulfide bonds 32-47; 36-54; 48-55." "Gram-positive bacteria: Aerococcus viridans (MIC=0.3-0.6 ?M), Micrococcus luteus (MIC=1.25-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Enterococcus fecalis (MIC>20 ?M), Saphylococcus aureus (MIC>40 ?M);##Gram-negative bacteria: Escherichia coli 363 (MI=10-20 ?M), Vibrio vulnificus (MIC>20 ?M), Salmonella thyphimurium (MIC>40 ?M), Klebsiella pneumoniae (MIC>40 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Neurospora crassa (MIC=1.25-2.5 ?M), Aspergillus fumigatus (MIC>20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic pyroglutamic acid Amidation "Disulfide bonds between Cys32 and Cys47,Cys36 and Cys54,Cys48 and Cys55. O-glycosylated on Thr8" L No cytotoxicity information found Chitin-binding 9353298##10561573##12842879 J Biol Chem. 1997 Nov 7;272(45):28398-28406.##Eur J Biochem. 1999 Dec;266(2):335-346.##J Biol Chem. 2003 Sep 19;278(38):36859-36867. "Destoumieux D, Bulet P, Loew D, Van Dorsselaer A, Rodriguez J, Bachre E.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bachre E.##Yang Y, Poncet J, Garnier J, Zatylny C, Bachre E, Aumelas A." "Penaeidins, a new family of antimicrobial peptides isolated from the shrimp Penaeus vannamei (Decapoda).##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp.##Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide." DRAMP02574 QVYKGGYARPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYSG 63 "[T8A]-Penaeidin-3a ([T8A]-Pen-3a; shrimps, Arthropods, animals)" P81058 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 11 residues) "[T8A]-Pen-3a structure consists of an unconstrained and a constrained part, which roughly match with the proline-rich (1-28 residues) and the cysteine-rich (29-58 residues) domains, respectively. The proline-rich domain does not adopt a constrained structure, whereas the cysteine-rich domain adopts a well-defined structure that consists of a helix (41-50 residues) tightly bound to the upstream (27-40 residues) and the downstream (51-63 " 1UEO resolved by NMR. "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity. PTM: Contains three disulfide bonds." "Gram-positive bacteria: Aerococcus viridans (MIC=0.4-0.8 ?M), Micrococcus luteus (MIC=0.8-1.6 ?M), Bacillus megaterium (MIC=3.12-6.25 ?M);##Gram-negative bacteria: Escherichia coli 363 (MI=3.12-6.25 ?M), Vibrio vulnificus (MIC>50 ?M), Salmonella thyphimurium (MIC>50 ?M), Klebsiella pneumoniae (MIC>50 ?M).##Fungi: Fusarium oxysporum (MIC=3.12-6.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic pyroglutamic acid Amidation "Disulfide bonds between Cys32 and Cys47,Cys36 and Cys54,Cys48 and Cys55. O-glycosylated on Thr8" L No cytotoxicity information found Not found 12842879 J Biol Chem. 2003 Sep 19;278(38):36859-36867. "Yang Y, Poncet J, Garnier J, Zatylny C, Bachre E, Aumelas A." "Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide." DRAMP18370 RERSKGSKYLYVG 13 "Crinicepsin-2 (insects, arthropods, invertebrates, animals)" No entry found Not found Not found "working ants, Trichomyrmex criniceps" "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: S. aureus (MIC 62 ug/ml), and weakly active against E. coli and V. cholerae (MIC 125 ug/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 28346717 Arch Insect Biochem Physiol. 2017 Mar 27. in press. "Bhagavathula N, Meedidoddi V, Bourque S, Vimaladevi R, Kesavakurup S, Selvadurai D, Shrivastava S, Krishnappa C." "Characterization of two novel antimicrobial peptides from the cuticular extracts of the ant Trichomyrmex criniceps (Mayr), (Hymenoptera: Formicidae)." DRAMP18371 VGVGGGFGR 9 "Crinicepsin-1 (insects, arthropods, invertebrates, animals)" No entry found Not found Not found "working ants, Trichomyrmex criniceps" "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacteria: S. aureus (MIC 125 ug/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 28346717 Arch Insect Biochem Physiol. 2017 Mar 27. in press. "Bhagavathula N, Meedidoddi V, Bourque S, Vimaladevi R, Kesavakurup S, Selvadurai D, Shrivastava S, Krishnappa C." "Characterization of two novel antimicrobial peptides from the cuticular extracts of the ant Trichomyrmex criniceps (Mayr), (Hymenoptera: Formicidae)." DRAMP02584 HSSGYTRPLPKPSRPIFIRPIGCDVCYGIPSSTARLCCFRYGDCCHR 47 "Penaeidin-4a (Pen-4a; shrimps, Arthropods, animals)" Q95NT0 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity (By similarity). PTM: Contains three disulfide bonds 23-37; 26-44; 38-45 and C-terminal amidation." "Gram-positive bacteria: Aerococcus viridans (MIC=1.9-2.92 ?M), Micrococcus luteus (MIC=1.9-2.92 ?M), Bacillus megaterium (MIC>50 ?M), Saphylococcus aureus (MIC>50 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC=22-33 ?M), Vibrio vulnificus (MIC>50 ?M), Salmonella thyphimurium (MIC>50 ?M), Klebsiella pneumoniae (MIC>50 ?M).##Fungi: Fusarium oxysporum (MIC=0.84-1.26 ?M), Botrytis cinerea (MIC=4.38-6.57 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation "Disulfide bonds between Cys23 and Cys37,Cys26 and Cys44,Cys38 and Cys45." L No cytotoxicity information found Chitin-binding 12242595##15084144 Immunogenetics. 2002 Sep;54(6):442-445.##Biochem J. 2004 Jul 1;381(Pt 1):79-86. "Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Cuthbertson BJ, Bullesbach EE, Fievet J, Bachre E, Gross PS." Diversity of the penaeidin antimicrobial peptides in two shrimp species.##A new class (penaeidin class 4) of antimicrobial peptides from the Atlantic white shrimp (Litopenaeus setiferus) exhibits target specificity and an independent proline-rich-domain function. DRAMP02586 QRGGFTGPIPRPPPHGRPPLGPICNACYRLSFSDVRICCNFLGKCCHLVK 50 "Penaeidin-2d (Pen-2d; shrimps, Arthropods, animals)" Q962A9 Belongs to the penaeidin family Not found Litopenaeus setiferus (Atlantic white shrimp) (Penaeus setiferus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity). Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of hemocytes and to a lesser." "Gram-positive bacteria: Aerococcus viridans (MIC=1.25-2.5 ?M), Micrococcus luteus (MIC=2.5-5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Enterococcus fecalis (MIC>20 ?M), Saphylococcus aureus (MIC>20 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC>40 ?M), Vibrio vulnificus (MIC>20 ?M), Salmonella thyphimurium (MIC>20 ?M), Klebsiella pneumoniae (MIC>20 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Neurospora crassa (MIC=2.5-5 ?M), Aspergillus fumigatus (MIC>20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 12242595##10561573 Immunogenetics. 2002 Sep;54(6):442-445.##Eur J Biochem. 1999 Dec;266(2):335-346. "Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bachre E." "Diversity of the penaeidin antimicrobial peptides in two shrimp species.##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp." DRAMP02591 HSSGYTRPLRKPSRPIFIRPIGCDVCYGIPSSTARLCCFRYGDCCHL 47 "Penaeidin-4d (Pen-4d; shrimps, Arthropods, animals)" Q962A7 Belongs to the penaeidin family Not found Litopenaeus setiferus (Atlantic white shrimp) (Penaeus setiferus) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Alpha helix (1 helices; 9 residues) "Calculation of PEN4 three-dimensional structure reveales that the PEN4 structure consisted of an unconstrained and a constrained part, which roughly match with the PRD (residues 1-17) and the CRD (residues 18-47), respectively. The global fold of the CRD mainly consisted of a helix (residues 31-41), two turns of type IV (Cys23-Cys26 and Gly42-Cys45 residues), and one loop spanning 27-30 residues (Ref.2)." 1XV3 resolved by NMR. "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity (By similarity). PTM: Contains three disulfide bonds 23-37; 26-44; 38-45." "Fungi: Fusarium oxysporum (MIC=0.84-1.26 ?M), Botrytis cinerea (MIC=4.38-6.57 ?M), Penicillium crustosum (MIC=1.26-1.9 ?M).## Gram-positive bacteria: Aerococcus viridans (MIC=1.9-2.92 ?M), Bacillus megaterium (MIC>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 12242595##15699044 Immunogenetics. 2002 Sep;54(6):442-445.##J Biol Chem. 2005 Apr 22;280(16):16009-18. "Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Cuthbertson BJ, Yang Y, Bachre E, Bllesbach EE, Gross PS, Aumelas A." Diversity of the penaeidin antimicrobial peptides in two shrimp species.##Solution structure of synthetic penaeidin-4 with structural and functional comparisons with penaeidin-3. DRAMP02603 AALRGALRAVARVGKAILPHVAIANPYVRTPYVHNNP 37 "Putative antimicrobial peptide A Northern Europe Heligoland (chordates, animals)" No entry found Not found Not found Ciona intestinalis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus megaterium (MIC=0.1 ?M), Bacillus subtilis (MIC=3.1 ?M), Staphylococcus aureus (MIC>25 ?M), Staphylococcus epidermidis (MIC=25 ?M).##Gram-negative bacteria: Escherichia coli K12 D31 (MIC=0.8 ?M), Y. enterocolitica (MIC=3.1 ?M), Klebsiella pneumoniae (MIC>25?M), Pseudomonas aeruginosa (MIC=12.5 ?M), Serratia marcescens(MIC>25 ?M).##Fungi: Candida albicans ATCC 10261 (MIC=6.3 ?M), Candida albicans SC 5314 (MIC=6.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17658598 Dev Comp Immunol. 2008;32(3):286-298. "Fedders H, Leippe M." A reverse search for antimicrobial peptides in Ciona intestinalis: identification of a gene family expressed in hemocytes and evaluation of activity. DRAMP02609 RLGDILQKAREKIEGGLKKLVQKIKDFFGKFAPRTES 37 "CjaRL-37 (cathelicidin; primates, mammals, animals)" No entry found Not found Not found Platyrrhini (New World monkeys) "Antimicrobial, Antibacterial, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "In 20% TSB in SPB medium: Escherichia coli (MIC=4 ?M), Pseudomonas aeruginosa (MIC>32 ?M); Staphylococcus aureus (MIC=32 ?M), Enterococcus faecalis (MIC>32 ?M).##In 20% SAB in SPB medium: Candida albicans (MIC>32 ?M). In 5% SAB in SPB Candida albicans (MIC>32 ?M). In 20% SAB in PIL Candida albicans (MIC>32 ?M).##In 5% TSB in SPB Escherichia coli (MIC=1 ?M), Pseudomonas aeruginosa (MIC=2 ?M), Staphylococcus aureus (MIC=8-16 ?M).##In 20% TSB in PIL Escherichia coli (MIC>32 ?M), Pseudomonas aeruginosa (MIC>32 ?M); Staphylococcus aureus (MIC=16 ?M), Enterococcus faecalis (MIC>32 ?M).##In 50% MH in SPB medium Escherichia coli (MIC>32 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16720578 J Biol Chem. 2006 Jul 21;281(29):19861-19871. "Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A." Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity. DRAMP02650 APIIRRIPYYPEVESDLRIVDCKRSEGFCQEYCNYLETQVGYCSKKKDACCLH 53 "Sperm associated antigen 11 isoform C (primates, mammals, animals)" No entry found Not found Not found Macaca mulatta (Rhesus monkey) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=50-100 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15229135 Biol Reprod. 2004 Nov;71(5):1453-1460. "Avellar MC, Honda L, Hamil KG, Yenugu S, Grossman G, Petrusz P, French FS, Hall SH." Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta). DRAMP02727 SLGNFFRKARKKIGEEFKRIVQRIKDFLQHLIPRTEA 37 "HmdSL-37 (cathelicidin; primates, mammals, animals)" No entry found Not found Not found Hylobates sp. (Gibbon) "Antimicrobial, Antibacterial, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "In 20% TSB in SPB medium Escherichia coli (MIC=2 ?M), Pseudomonas aeruginosa (MIC=8 ?M), Staphylococcus aureus (MIC>32 ?M), Enterococcus faecalis (MIC=8 ?M).##In 20% SAB in SPB Candida albicans (MIC>32 ?M). In 5% SAB in SPB Candida albicans (MIC=8 ?M). In 20% SAB in PIL Candida albicans (MIC>32 ?M).##In 5% TSB in SPB Escherichia coli (MIC=1 ?M), Pseudomonas aeruginosa (MIC=2 ?M), Staphylococcus aureus (MIC=2 ?M).##In 20% TSB in PIL Escherichia coli (MIC>32 ?M), Pseudomonas aeruginosa (MIC=16-32 ?M); Staphylococcus aureus (MIC=8-16 ?M), Enterococcus faecalis (MIC>32 ?M).##In 50% MH in SPB medium Escherichia coli (MIC>32 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16720578 J Biol Chem. 2006 Jul 21;281(29):19861-19871. "Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A." Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity. DRAMP18369 VSFPWSCAALSGVCRQGACLPSELYFGPLGCGKGSLCCVSYFL 43 ccBD(channel catfish beta defensin) No entry found Belongs to the beta-defensin family. Not found "skin, Ictalurus punctatus" "Antimicrobial, Antibacterial" bridge Not found None Comment: No comments found on DRAMP database "Active against Gram- E. coli, E. ictaluri, Y. ruckeri, A. hydrophila, A. veronii, Gram+ S. aureus, S. iniae, and S. agalactiae (MIC 12.5-25 ug/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys7 and Cys37,Cys14 and Cys31,Cys19 and Cys38." L No cytotoxicity information found Not found 28340427 Mol Immunol. 2017 Mar 21;85:256-264. "Zhu J, Wang H, Wang J, Wang X, Peng S, Geng Y, Wang K, Ouyang P, Li Z, Huang X, Chen D." Identification and characterization of a DRAMP02740 YDLSKNCRLRGGICYIGKCPRRFFRSGSCSRGNVCCLRFG 40 "TBD-1 (Turtle beta-defensin 1; Reptiles, animals)" P86253 Belongs to the beta-defensin family Not found Emys orbicularis (European pond turtle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against the Gram-positive bacteria methicillin-resistant S. aureus ATCC 33591 and L. monocytogenes EGD, the Gram-negative bacterium E. coli ML53p and the yeast C. albicans 820. Has no hemolytic activity towards human erythrocytes. PTM: Contains three disulfide bonds 7-35; 14-29; 19-36." "[Ref.19253295]Gram-negative bacterium (LS, HS): Escherichia coli ML35p (MIC=0.65, >20 ?mol/L);##Gram-positive bacteria: (LS, HS): Listeria monocytogenes EGD (MIC=0.65, >20 ?mol/L), Methicillin-resistant Staphylococcus aureus ATCC 33591 (MIC=5.6, >20 ?mol/L).##Yeast: Candida albicans (MIC=5.2, >20 ?mol/L).##NOTE: LS (low salt): 10 mmol/L sodium phosphate buffer (pH 7.4) and HS (high salt): 10 mmol/L sodium-phosphate buffer (pH 7.4), 0.1 mol/L sodium chloride." [Ref.19253295] It has no hemolytic activity against human erythrocytes up to 25 mmol/L Cyclic Free Free Disulfide bonds between Cys7 and Cys35; Cys14 and Cys29; Cys19 and Cys36. L No cytotoxicity information found Not found 19253295 Proteomics. 2009 Mar;9(5):1364-1373. "Stegemann C, Kolobov A Jr, Leonova YF, Knappe D, Shamova O, Ovchinnikova TV, Kokryakov VN, Hoffmann R." "Isolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles." DRAMP02768 GLGSVFGRLARILGRVIPKVAKKLGPKVAKVLPKVMKEAIPMAVEMAKSQEEQQPQ 56 "Pilosulin-1 (Myr b I; ants, insects, animals)" "Q07932, Q9TWC1" Belongs to the pilosulin family Not found Myrmecia banksi (Jack jumper ant) (Australian jumper ant) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. The synthesized peptide 57-76 shows a potent and broad spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, and also against the fungus C. albicans. Adopts an alpha-helical structure. Tissue specificity: Expressed by the venom gland. Allergenic properties: Causes an allergic reaction in human." "[Ref.9813247]Gram-positive bacteria: Micrococcus luteus (MIC=0.5 ?M), Enterococcus spp.I-11305b (MIC=2 ?M), Enterococcus spp. I-11054 (MIC=2 ?M), Staphylococcus simulans 22 (MIC=2 ?M), S. haemolyticus I-10925 (MIC=2 ?M), S. epidermidis LT1324 (MIC=2 ?M), S. aureuss 5185 (MI=2 ?M), S. aureuss methicillin-sensitive I-11574 (MIC=2 ?M), S. aureuss (MRSA) LT1338 (MIC=3 ?M), S. aureuss (MRSA) LT1334 (MIC=1.5 ?M);##Gram-negative bacteria: Citrobacter freundii I-11090 (MIC=2 ?M), Klebsiella pneumoniae I-10910 (MIC=2 ?M), Escherichia coli I-11276b (MIC=4 ?M), E. coli O-19592 (MIC=2 ?M), Stenotrophomonas maltophilia O-16451 (MIC=2 ?M), S. maltophila I-10717 (MIC=2 ?M), Pseudomonas aeruginosa 4991 (MIC=4 ?M), Pseudomonas aeruginosa I-10968 (MIC=4 ?M);##Fungi: Candida albicans I-11301 (MIC=4 ?M), Candida albicans I-11134 (MIC>4 ?M)." [Ref.9813247]Complete lysis in the presence of pilosulin 1 was obtained at a concentration of 40 M with evidence of partial lysis visible down to 1.25 M Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet IgE 9813247##9701394##15639237##8866004 Arch Biochem Biophys. 2005 Feb 15;434(2):358-364.##Cytometry. 1998 Aug 1;32(4):268-273.##Arch Biochem Biophys. 2005 Feb 15;434(2):358-364.##Biochem Mol Biol Int. 1996 Aug;39(5):877-885. "Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.##King MA, Wu QX, Donovan GR, Baldo BA.##Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.##Donovan GR, Street MD, Tetaz T, Smith AI, Alewood D, Alewood P, Sutherland SK, Baldo BA." Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.##Flow cytometric analysis of cell killing by the jumper ant venom peptide pilosulin 1.##Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.##Expression of jumper ant (Myrmecia pilosula) venom allergens: post-translational processing of allergen gene products. DRAMP02777 SLQPGAPNFPMPGSQLPTSITSNIEKQGPNTAATINAQHKTDRYDVGATWSKVIRGPGRSKPNWSIGGTYRW 72 "Rhinocerosin (Insects, animals)" O76145 Belongs to the coleoptericin family Not found Oryctes rhinoceros (Coconut rhinoceros beetle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has strong antibacterial activity against Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus but not against Pseudomonas aeruginosa." "Gram-positive bacteria: Staphylococcus aureus (MIC=1 ?g/ml), Streptococcus pyogenes (MIC=1 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9738915 Eur J Biochem. 1998 Aug 1;255(3):734-738. "Yang J, Yamamoto M, Ishibashi J, Taniai K, Yamakawa M." "Isolation, cDNA cloning and gene expression of an antibacterial protein from larvae of the coconut rhinoceros beetle, Oryctes rhinoceros." DRAMP01623 LIGPVLGLVGSALGGLLKKI 20 "Bombinin-H4 (bombinin H isomers; Frogs, amphibians, animals)" P82284 Belongs to the bombinin family Not found Bombina variegata (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, hemolytic against mammalian cells, Antifungal" Protein level Alpha helix "The epimerization reaction is incomplete, or, after racemization, the peptides still containing the L-amino acid in position 2 are partly degraded." None Function: Have antimicrobial activity. Have some hemolytic activity. [Ref.8223491] Gram-negative bacterium: Escherichia coli D21 (MIC=4.8 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.3 ?M). [Ref.8223491] Lethal concentration is 14.6 ?M against human red blood cell. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8223491 EMBO J. 1993; 12:4829-4832. "Mignogna G, Simmaco M, Kreil G, Barra D.1993" Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata. DRAMP02779 VTCDLLSFEAKGFAANHSICAAHCLAIGRKGGSCQNGVCVCRN 43 "Defensin-A (Defensin A; Insects, animals)" P83669 Belongs to the invertebrate defensin family (Type 1 subfamily) Not found Anomala cuprea (Cupreous chafer beetle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Strong activity against the Gram-positive bacteria M.luteus, B.megaterium and S. aureus. Reduced activity against Gram-positive bacterium B.subtilis and weak activity against Gram-negative bacterium X.japonicus. PTM: Problely contains three disulfide bonds 3-34; 20-39; 24-41." "Gram-positive bacteria: Bacillus megaterium (MIC=1.2-2.5 ?M), Bacillus subtilis (MIC>40 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Staphylococcus aureus (MIC=2.5-5 ?M).##Gram-negative bacteria: Enterobacter asbriae (MIC>40 ?M), Escherichia coli (MIC>40 ?M), Pseudomonas aeruginosa (MIC>40 ?M), Serratia marcescens (MIC>40 ?M), Xenorhabdus japonicus (MIC>40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys3 and Cys34; Cys20 and Cys39; Cys24 and Cys41. L No cytotoxicity information found Not found 11719071 Insect Biochem Mol Biol. 2001 Dec;32(1):75-84. Yamauchi H. "Two novel insect defensins from larvae of the cupreous chafer, Anomala cuprea: purification, amino acid sequences and antibacterial activity." DRAMP02780 VTCDLLSFEAKGFAANHSICAAHCLVIGRKGGACQNGVCVCRN 43 "Defensin-B (Defensin B; Insects, animals)" P83668 Belongs to the invertebrate defensin family (Type 1 subfamily) Not found Anomala cuprea (Cupreous chafer beetle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has antibacterial activity against Gram-positive bacteria and the Gram-negative bacterium X. japonicus. PTM: Problely contains three disulfide bonds 3-34; 20-39; 24-41." "Gram-positive bacteria: Bacillus megaterium (MIC=1.2-2.5 ?M), Bacillus subtilis (MIC=20-40 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Staphylococcus aureus (MIC=2.5-5 ?M);##Gram-negative bacterium: X. japonicus (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys3 and Cys34; Cys20 and Cys39; Cys24 and Cys41. L No cytotoxicity information found Not found 11719071 Insect Biochem Mol Biol. 2001 Dec;32(1):75-84. Yamauchi H. "Two novel insect defensins from larvae of the cupreous chafer, Anomala cuprea: purification, amino acid sequences and antibacterial activity." DRAMP02802 AREASKSLIGTASCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR 46 "Paneth cell-specific alpha-defensin 1 (DEFA1; horse defensin; houses, mammals, animals" A6YB85 Not found DEFA1 Equus caballus (Horse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found 2MXQ resolved by NMR. Function: Membrane permeabilization is at least an essential part of the peptide's mode of action. "Gram-negative bacteria: Escherichia coli [ATCC 11775 (MBC=0.4 ?M); ATCC 25922 (MBC=0.4 ?M); ATCC 35218 (MBC=0.4 ?M)], E. coli D31 (MBC=0.8 ?M), Pseudomonas aeruginosa ATCC 11440 (MBC=3 ?M);##Gram-positive bacteria: Staphylococcus aureus [ATCC 6538 (MBC=0.8 ?M); ATCC 12600 (MBC=1.5 ?M)], Staphylococcus epidermidis ATCC 14990 (MBC=1.5 ?M), Enterococcus faecalis ATCC 29212 (MBC=6.1 ?M), E. faecalis PEG 205 (wild-type) (MBC=3 ?M), Streptococcus pyogenes ATCC 12344 (MBC=0.8 ?M), Bacillus megaterium ATCC 14581 (MBC=0.2 ?M).##Yeast: Candida albicans ATCC 24433 (MIC=0.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys14 and Cys44; Cys16 and Cys32; Cys22 and Cys43. L No cytotoxicity information found Not found 17620056 Biochem J. 2007 Oct 15;407(2):267-276. "Bruhn O, Regenhard P, Michalek M, Paul S, Gelhaus C, Jung S, Thaller G, Podschun R, Leippe M, Gr?tzinger J, Kalm E." "A novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function." DRAMP02809 HPHVCTSYYCSKFCGTAGCTRYGCRNLHRGKLCFCLHCSR 40 "Myticin-B (Myt B; Cys-rich; molluscas, animals)" P82102 Not found Not found Mytilus galloprovincialis (Mediterranean mussel) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Rich Not found None "Function: Bacteriolytic activity against Gram-positive bacteria and Gram-negative bacteria. Also possesses antifungal activity against F. oxysporum. PTM: contains four disulfide bonds." "Gram-positive bacteria: Micrococcus luteus (MBC=1-2 ?M), Bacillus megaterium (MBC=1-2 ?M), Aerococcus viridans (MBC=2-4 ?M).##Gram-negative bacteria: Escherichia coli D31 (MBC=20-10 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free contains four disulfide bonds. L No cytotoxicity information found Not found 10491159 Eur J Biochem. 1999 Oct 1;265(1):71-78. "Mitta G, Hubert F, No?l T, Roch P." "Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis." DRAMP02811 GFGCPNNYQCHRHCKSIPGRCGGYCGGWHRLRCTCYRC 38 "Defensin MGD-1 (molluscas, animals)" "P80571, Q9Y0B0" Not found FH3 Mytilus galloprovincialis (Mediterranean mussel) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Combine helix and strand structure "The three-dimensional solution structure of MGD-1 has been established using (1)H NMR and mainly consists of a helical part (Asn7-Ser16) and two antiparallel beta-strands (Arg20-Cys25 and Cys33-Arg37), together giving rise to the common cystine-stabilized alpha-beta motif frequently observed in scorpion toxins. In MGD-1, the cystine-stabilized alpha-beta motif is stabilized by four disulfide bonds (Cys4-Cys25, Cys10-Cys33, Cys14-Cys35, " 1FJN resolved by NMR. "Function: Active against both Gram-positive and Gram-negative bacteria but is not cytotoxic towards human erythrocytes or protozoa. Transgenic plants: expression of this peptide in tobacco improves resistance to pathogens. PTM: Contains four disulfide bonds 4-25; 10-33; 14-35; 21-38." "Gram-positive bacteria: Micrococcus luteus (MIC=0.4 ?M)&(MBC=1.5 ?M), Bacillus megaterium (MIC=0.8 ?M)&(MBC=1.5 ?M), Staphylococcus aureus (MIC=0.6 ?M)&(MBC=1.2 ?M), Staphylococcus epidermidis (MIC=3.1 ?M)&(MBC=6.2 ?M), Enterococcus fecalis (MIC=0.6 ?M)&(MBC=1.2 ?M), Aerococcus viridans (MIC=0.4 ?M)&(MBC=1.5 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC=1.2 ?M)&(MBC=1.2 ?M), E. coli 363 (MIC=1.2 ?M)&(MBC=1.2 ?M), Salmonella newport (MIC>100 ?M)&(MBC>100 ?M), Vibrio alginolyticus (MIC=50 ?M)&(MBC>100 ?M), Vibrio harveyi (MIC=50 ?M)&(MBC=100 ?M), Vibrio metshnikovii (MIC>100 ?M)&(MBC>100 ?M).##NOTE: MIC=minimal inhibitory concentration; MBC = minimal bactericidal concentration." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bond between Cys4 and Cys25, Cys10 and Cys33, Cys14 and Cys35,Cys21 and Cys38." L No cytotoxicity information found Not found 10564642##8925841##11087396 J. Cell Sci. 1999;112:4233-4242.##Eur. J. Biochem. 1996;240:302-306.##Biochemistry 2000 Nov 28;39(47):14436-47. "Mitta G, Vandenbulcke F, Hubert F, Roch P.##Hubert F, Noeel T, Roch P.##Yang YS, Mitta G, Chavanieu A, Calas B, Sanchez JF, Roch P, Aumelas A." Mussel defensins are synthesised and processed in granulocytes then released into the plasma after bacterial challenge.##A member of the arthropod defensin family from edible Mediterranean mussels (Mytilus galloprovincialis).##Solution structure and activity of the synthetic four-disulfide bond Mediterranean mussel defensin (MGD-1). DRAMP02813 FHPSLWVLIPQYIQLIRKILKSG 23 Conolysin-Mt1 P0C8S6 Not found Not found Conus mustelinus (Weasel cone) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: This cytolytic peptide has ability to disrupt the integrity of cell membranes from both prokaryotes and eukaryotes. It permeabilizes both negatively charged prokaryotic (PE:PG) and zwitterionic eukaryotic (PC:cholesterol) model membranes. It has potent hemolytic activity on human erythrocytes and exhibits low antimicrobial activity against the Gram-negative bacterium E. coli and the Gram-positive bacterium S. aureus. Intracranial injection causes mice to shuffle backward until the encounter an obstacle, at which time the mouse jump into the air. The backward shuffle is reminiscent to the signature dance 'moonwalk' that gained widespread popularity after being performed by Michael Jackson. Tissue specificity: Expressed by the venom duct. Miscellaneous: The mature peptide does not contain cysteine residue. Mt1 and Mt2 peptides are found in a ratio of 1:4. Mt1 is more active when intracranially injected." [Ref.17927208]Gram-positive bacterium: Staphylococcus aureus (MIC=25-50 ?M);##Gram-positive bacterium: Escherichia coli (MIC>50 ?M). [Ref.17927208]95% hemolytic activity at 25 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17927208 Biochemistry. 2007 Nov 6;46(44):12586-12593. "Biggs J.S, Rosenfeld Y, Shai Y, Olivera B.M." Conolysin-Mt: a conus peptide that disrupts cellular membranes. DRAMP02817 VDKGSYLPRPTPPRPIYNRN 20 Pyrrhocoricin "P37362, P80307" Belongs to the drosocin family Not found Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Combine helix and strand structure Not found 4EZN resolved by X-ray. "Function: Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis." "Gram-positive bacteria: Micrococcus luteus (MIC>80 ?M in L.B, P.B), Bacillus megaterium (MIC>80 ?M in L.B, P.B);##Gram-negative bacteria: Escherichia coliD22 (MIC=0.3 ?M in L.B, P.B), A.tumefaciens (MIC=1.25 ?M in LB and 3 ?M in PB), Salmonella typhimurium (MIC=5 ?M in L.B and 10 ?M in P.B)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10076062##8002963##23562829 Biochim Biophys Acta. 1999 Feb 2;1426(3):459-467.##Biochem J. 1994 Jun 1;300 (Pt 2):567-575.##J Mol Biol. 2013 Jul 24;425(14):2463-2479. "Hoffmann R, Bulet P, Urge L, Otv?s L Jr.##Cociancich S, Dupont A, Hegy G, Lanot R, Holder F, Hetru C, Hoffmann JA, Bulet P.##Zahn M, Berthold N, Kieslich B, Knappe D, Hoffmann R, Str?ter N." "Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects.##Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.##Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK." DRAMP02835 FAEPLPSEEEGESYSKEVPEMEKRYGGFM 29 "Enkelytin (one chain of Proenkephalin-A; mammals, animals)" "P01211, Q2T9T4" Belongs to the opioid neuropeptide precursor family PENK Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus (MIC=0.2-0.4 ?M), Bacillus megaterium (MIC=0.2-0.4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 6952189##8654396 Proc Natl Acad Sci U S A. 1982 Jan;79(2):360-364.##Eur J Biochem. 1996 Feb 1;235(3):516-525. "Comb M, Herbert E, Crea R.##Goumon Y, Strub JM, Moniatte M, Nullans G, Poteur L, Hubert P, Van Dorsselaer A, Aunis D, Metz-Boutigue MH." Partial characterization of the mRNA that codes for enkephalins in bovine adrenal medulla and human pheochromocytoma.##The C-terminal bisphosphorylated proenkephalin-A-(209-237)-peptide from adrenal medullary chromaffin granules possesses antibacterial activity. DRAMP01381 GLFTLIKGAAKLIGKTVPKKQARLGMNLWLVKLPTNVKT 39 "Odorranain-K1 (OdK1; Frogs, amphibians, animals)" A6MBN8 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-K1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 g/ml), Bacillus subtilis (MIC=1.10 g/ml).##Yeast: Candida albicans (MIC=1.10 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01383 ATAWDFGPHGLLPIRPIRIRPLCGKDKS 28 "Odorranain-M1 (OdM1; Frogs, amphibians, animals)" A6MBP6 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-M1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=9.37 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 g/ml), Bacillus subtilis (MIC=75 g/ml).##Yeast: Candida albicans (MIC=18.75 g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02841 RQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIK 34 Lumbricin I(6C34) O96447 Not found Not found Synthetic construct (derived from residues 6C34 of lumbricin I) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Lumbricin I(6-34) has marginally stronger antimicrobial activities than lumbricin I. Has weak hemolytic activity when tested against human erythrocytes. "[Ref.9784609]Gram-positive bacteria: Bacillus subtilis ATCC 62037 (MIC=8 ?g/ml), Staphylococcus aureus ATCC 15752 (MIC=12 ?g/ml), Streptococcus mutans ATCC 25175 (MIC=20 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 27325 (MIC=8 ?g/ml), Pseudomonas putidaATCC 17426 (MIC=12 ?g/ml), Serratia sp. ATCC 21074 (MIC=12 ?g/ml).##Fungi: Candida albicans ATCC 10231 (MIC=12 ?g/ml), Cryptococcus neoformance ATCC 34881 (MIC=16 ?g/ml), Saccharomyces cerevisiae ATCC 44774 (MIC=8 ?g/ml).##NOTE: Minimal inhibitory concentrations were determined by incubating approximately 104C105 CFU/ml of cells with serial dilutions of each peptide in a 96-well microtiter plate.." "[Ref.9784609]0.03% hemolytic activity at 5 g/ml, 0.07% hemolytic activity at 10 g/ml, 0.13% hemolytic activity at 25 g/ml, 0.17% hemolytic activity at 50 g/ml, 0.21% hemolytic activity at 100 g/ml against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784609 Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76. "Cho JH, Park CB, Yoon YG, Kim SC." "Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization." DRAMP02843 ILKKWPWWPWRRKX 14 "chain a, Structure Of An Indolicidin Peptide Derivative With" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Non helix or strand structure Not found 1QXQ resolved by NMR. Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=8 ?g/ml), Pseudomonas aeruginosa (MIC=16 ?g/ml), Salmonella typhimurium (MIC=64 ?g/ml), S. typhimurium defensin sensitive (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) (MIC=16 ?g/ml), S. epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11123901 Biochemistry. 2000 Dec 26;39(51):15765-15774. "Rozek A, Friedrich CL, Hancock RE." Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles. DRAMP02844 ILAWKWAWWAWRR 13 "CP10A (Indolicidin peptide derivative; mammals, animals)" P33046 Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Alpha helix (1 helices; 8 residues) The structure of CP10A in DPC micelles determined from NMR data is mainly a-helical with elements of 310 helical geometry. 1HR1 resolved by NMR. "Function: A derivative of indolicidin, CP10A, has alanine residues substituted for proline residues and has improved activity against Gram-positive organisms. Chemical modification: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4 ?g/ml), S. aureus SAP0017 MRSA (MIC=4 ?g/ml), Staphylococcus haemolyticus Clinical isolate (MIC=2 ?g/ml), S. haemolyticus Vancomycin-resistant isolate (MIC=1 ?g/ml), Staphylococcus epidermidis Clinical isolate (MIC=2 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC=8 ?g/ml), Listeria monocytogenes NCTC 7973 (MIC=1 ?g/ml), Streptococcus pyogenes ATCC 19615 (MIC=1 ?g/ml), Corynebacterium xerosis Lab strain (MIC=1 ?g/ml).(Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11294848 "Antimicrob. Agents Chemother. 1999,43:1542-1548." "Friedrich, C, M. G. Scott, N. Karunaratne, H. Yan, and R. E. Hancock." "Salt-resistant alpha-helical cationic antimicrobial peptides.##Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria." DRAMP02845 ICLKKWPWWPWRRCKX 16 "CP-11 (cathelicidin; mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Non helix or strand structure Not found 1QX9 resolved by NMR. Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=16 ?g/ml), Pseudomonas aeruginosa (MIC=64 ?g/ml), Salmonella typhimurium(MIC=64 ?g/ml), S. typhimurium defensin sensitive (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) (MIC=16 ?g/ml), S. epidermidis(MIC=8 ?g/ml), Enterococcus faecalis (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11123901##14640680 Biochemistry. 2000 Dec 26;39(51):15765-15774.##Biochemistry. 2003 Dec 9;42(48):14130-14138. "Rozek A, Friedrich CL, Hancock RE.##Rozek, A.; Powers, JP.; Friedrich, CL.; Hancock, RE. " Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.##Structure-based design of an indolicidin peptide analogue with increased protease stability. DRAMP02849 RFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLRFP 42 "Bactenecin 5 (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Salmonella typhimurium (MIC=2-10 ?M), Klebsiella pneumoniae, Escherichia coli." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2229048 J Biol Chem. 1990 Nov 5;265(31):18871-18874. "Frank RW, Gennaro R, Schneider K, Przybylski M, Romeo D." Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils. DRAMP02851 RLCRIVVIRVCR 12 "Cathelicidin-1 (Bactenecin-1, Bac1; Cyclic dodecapeptide; mammals, animals)" "P22226, A5PJA3, Q24JY5" Belongs to the cathelicidin family CATHL1 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Three disulfide bonds. None "Function: Potent microbicidal activity; active against S.aureus and E.coli. Tissue specificity: Large granules of neutrophils. PTM: Contains three disulfide bonds." Gram-positive bacterium: Staphylococcus aureus (MIC=1-8 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=8-25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Not found 3290210 J Biol Chem. 1988 Jul 15;263(20):9573-9575. "Romeo D, Skerlavaj B, Bolognesi M, Gennaro R." Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils. DRAMP02854 GGLRSLGRKILRAWKKYGPIIVPIIRIG 28 Cathelicidin-5 (Antibacterial peptide BMAP-28; Myeloid antib "P54229, A5PJ96, B9UKL6" Belongs to the cathelicidin family CATHL5 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. PTM: Contains two disulfide bonds. (By similarity)" "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), E. coli ML35 (MIC=2 ?M), E. coli D21 (MIC=0.5 ?M), Salmonella typhimurium ATCC 14028 (MIC=1 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Staphylococcus aureus (MRSA) (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=8 ?M), Cryptococcus neoformans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461##8706679 J Biol Chem. 1996 Nov 8;271(45):28375-28381.##Eur J Biochem. 1996 Jun 15;238(3):769-776. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.##Storici P, Tossi A, Lenarcic B, Romeo D." "Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.##Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides." DRAMP02855 GRFKRFRKKFKKLFKKLSPVIPLLHLG 27 "Cathelicidin-6 (Antibacterial peptide BMAP-27, Myeloid antib" "P54228, B9UKM5" Belongs to the cathelicidin family CATHL6 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (2 helices; 19 residues) Not found 2KET resolved by NMR. "Function: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. PTM: Contains two disulfide bonds. (By similarity)" "Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1 ?g/ml), E. coli ML35 (MIC=1 ?g/ml), E. coli D21 (MIC=0.25 ?g/ml), Salmonella typhimurium ATCC 14028 (MIC=1 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?g/ml), Serratia marcescens ATCC 8100 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?g/ml), Staphylococcus aureus Cowan 1 (MIC=2 ?g/ml), Staphylococcus aureus (MRSA) (MIC=4 ?g/ml), S. epidermidis ATCC 12228 (MIC=1 ?g/ml), Bacillus megaterium Bm11 (MIC=2 ?g/ml).##Fungi: Candida albicans (MIC=8 ?g/ml), Cryptococcus neoformans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461##19136450##PubMed ID is not available J. Biol. Chem. 1996;271:28375-28381.##J. Hered. 2009;100:241-245.##To be Published "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.##Gillenwaters EN, Seabury CM, Elliott JS, Womack JE.##Yang S, Jung H, Kim J." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.##Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.##solution structure of BMAP-27. DRAMP02858 DFASCHTNGGICLPNRCPGHMIQIGICFRPRVKCCRSW 38 "Bovine Beta-defensin 1 (bBD-1; BNBD-1; BNDB-1; mammals, animals)" P46159 Belongs to the beta-defensin family DEFB1 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 but not against S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16777238 Vet Immunol Immunopathol. 2006 Sep 15;113(1-2):181-190. "Aono S, Li C, Zhang G, Kemppainen RJ, Gard J, Lu W, Hu X, Schwartz DD, Morrison EE, Dykstra C, Shi J." Molecular and functional characterization of bovine beta-defensin-1. DRAMP02859 VRNHVTCRINRGFCVPIRCPGRTRQIGTCFGPRIKCCRSW 40 "Bovine Beta-defensin 2 (bBD-2; BNBD-2; BNDB-2; mammals, animals)" P46160 Belongs to the beta-defensin family DEFB2 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 7-36; 14-29; 19-37. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02860 EGVRNHVTCRINRGFCVPIRCPGRTRQIGTCFGPRIKCCRSW 42 "Bovine Beta-defensin 3 (bBD-3; BNBD-3; BNDB-3; mammals, animals)" P46161 Belongs to the beta-defensin family DEFB3 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##9488394 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Infect Immun. 1998 Mar;66(3):1045-1056. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection." DRAMP02861 QRVRNPQSCRWNMGVCIPFLCRVGMRQIGTCFGPRVPCCRR 41 "Bovine Beta-defensin 4 (bBD-4; BNBD-4; BNDB-4; mammals, animals)" P46162 Belongs to the beta-defensin family DEFB4 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 520A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available##8454635 Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.##J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Yount N.Y, Yuan J, Diamond G, Tarver A, McGuire P.A, McCullough C, Cullor J.S, Bevins C.L, Selsted M.E.##Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Molecular cloning and expression of an antimicrobial beta-defensin from bovine neutrophils. Characterization of BNBD-4 cDNA and genomic sequences and localization of the peptide to large granules of mature neutrophils.##Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02862 QVVRNPQSCRWNMGVCIPISCPGNMRQIGTCFGPRVPCCRRW 42 "Bovine Beta-defensin 5 (bBD-5; BNBD-5; BNDB-5; mammals, animals)" "P46163, O97533" Belongs to the beta-defensin family DEFB5 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 but not against S. aureus 502A. Tissue specificity: Neutrophilic granules. Alveolar macrophages. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02863 QGVRNHVTCRIYGGFCVPIRCPGRTRQIGTCFGRPVKCCRRW 42 "Bovine Beta-defensin 6 (bBD-6; BNBD-6; BNDB-6; mammals, animals)" P46164 Belongs to the beta-defensin family DEFB6 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02865 VRNFVTCRINRGFCVPIRCPGHRRQIGTCLGPQIKCCR 38 "Bovine Beta-defensin 8 (bBD-8; BNBD-8; BNDB-8; mammals, animals)" P46166 Belongs to the beta-defensin family DEFB8 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 7-36; 14-29; 19-37. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02866 QGVRNFVTCRINRGFCVPIRCPGHRRQIGTCLAPQIKCCR 40 "Bovine Beta-defensin 9 (bBD-9; BNBD-9; BNDB-9; mammals, animals)" "P46167, O18814" Belongs to the beta-defensin family DEFB9 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-301 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##9488394 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Infect Immun. 1998 Mar;66(3):1045-1056. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection." DRAMP02867 QGVRSYLSCWGNRGICLLNRCPGRMRQIGTCLAPRVKCCR 40 "Bovine Beta-defensin 10 (bBD-10; BNBD-10; BNDB-10; mammals, animals)" "P46168, Q5W5G8" Belongs to the beta-defensin family DEFB10 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##15520886 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Mamm Genome. 2004 Oct;15(10):834-842. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Roosen S, Exner K, Paul S, Schr?der JM, Kalm E, Looft C." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue." DRAMP02868 GPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW 38 "Bovine Beta-defensin 11 (bBD-11; BNBD-11; BNDB-11; mammals, animals)" "P46169, Q5W5G7" Belongs to the beta-defensin family DEFB11 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##15520886 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##Mamm Genome. 2004 Oct;15(10):834-842. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Roosen S, Exner K, Paul S, Schr?der JM, Kalm E, Looft C." "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue." DRAMP02869 GPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW 38 "Bovine Beta-defensin 12 (bBD-12; BNBD-12; BNDB-12; mammals, animals)" P46170 Belongs to the beta-defensin family DEFB12 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Beta strand Not found 1BNB resolved by NMR. "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" Gram-positive bacterium: Staphylococcus aureus 502A (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli ML35 (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635##8454636 J Biol Chem. 1993 Mar 25;268(9):6641-6648.##J Biol Chem. 1993 Mar 25;268(9):6649-6653. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS.##Tang YQ, Selsted ME." "Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.##Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils." DRAMP02870 SGISGPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW 42 "Bovine Beta-defensin 13 (bBD-13; BNBD-13; BNDB-13; mammals, animals)" P46171 Belongs to the beta-defensin family DEFB13 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Bridge Not found None "Function: Has bactericidal activity. Active against E. coli ML35 and S. aureus 502A. Tissue specificity: Neutrophilic granules. PTM: Contains three disulfide bonds 9-38; 16-31; 21-39. (By similarity)" Gram-positive bacterium: Staphylococcus aureus (MIC=10-300 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=10-300 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8454635 J Biol Chem. 1993 Mar 25;268(9):6641-6648. "Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS." "Purification, primary structures, and antibacterial activities of Beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." DRAMP02872 GRFKRFRKKFKKLFKKLS 18 "Myeloid antimicrobial peptide BMAP-27 (1-18) (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), Escherichia coli ML35 (MIC=4 ?M), Escherichia coli D21 (MIC=4 ?M), Salmonella typhimurium ATCC 14028 (MIC=4 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Staphylococcus aureus (MRSA) (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=16 ?M), Cryptococcus neoformans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461 J Biol Chem. 1996 Nov 8;271(45):28375-28381. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. DRAMP02873 GGLRSLGRKILRAWKKYG 18 "Myeloid antimicrobial peptide BMAP-28 (1-18) (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=0.5 ?M), Escherichia coli D21 (MIC=0.5 ?M), Salmonella typhimurium ATCC14028 (MIC=2 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Staphylococcus aureus (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=16 ?M), Cryptococcus neoformans (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461 J Biol Chem. 1996 Nov 8;271(45):28375-28381. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. DRAMP02875 LPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQ 76 "Vasostatin-1 (VS-1; N-terminal fragment of Chromogranin-A; mammals, animals)" "P05059, P79392, Q2KJ52" Belongs to the chromogranin/secretogranin protein family CHGA Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None "Function: Vasostatin-1 has antibacterial activity against Gram-positive bacteria M. luteus, B. megaterium. Possesses antifungal activity against N. crassa, A. fumigatus, A. brassicicola, N. hematococca, F. culmorum and F. oxyporum and against the yeast S. cerevisiae and C. albicans. Miscellaneous: Binds calcium with a low-affinity." "Gram-positive bacteria: Micrococcus luteus (MIC=2 ?M), Bacillus megaterium (MIC=0.2 ?M).##Fungi: Neurospora crassa (MIC=3 ?M), Aspergillus fumigatus (MIC=5 ?M), Alternaria brassicicola (MIC=3 ?M), Nectria haematococca (MIC=1 ?M), Fusarium culmorum (MIC=1 ?M), F. oxyporum (MIC=10 ?M), Saccharomyces cerevisiae (MIC=10 ?M), Candida albicans (MIC=10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Binds calcium with a low-affinity. 10753865 J Biol Chem. 2000 Apr 14;275(15):10745-10753. "Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH." "Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A." DRAMP02877 GGLRSLGRKILRAWKKYGPQATPATRQ 27 "mBMAP28 (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=0.5 ?M), Salmonella typhimurium ATCC 14028 (MIC=1 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.5 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=2 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=8 ?M), Cryptococcus neoformans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461 J. Biol. Chem. 1996; 271:28375-28381 "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.1996" Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. DRAMP02878 NPVSCVRNKGICVPIRCPGSMKQIGTCVGRAVKCCRKK 38 "Tracheal antimicrobial peptide (TAP; mammals, animals)" "P25068, O97532" Belongs to the beta-defensin family (LAP/TAP subfamily) Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity in vitro. In addition, the peptide is active against Candida albicans, indicating a broad spectrum of activity. Tissue specificity: Tracheal epithelium. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" "Gram-negative bacteria: Escherichia coli D31 (MIC=12-25 ?g/ml), Klebsiella pneumoniae 13883 (MIC=12-25 ?g/ml), Pseudomonas aeruginosa 27853 (MIC=25-50 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=25-50 ?g/ml).##Fungi: Candida ablicans (MIC=6-12 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2023943##8506305 Proc Natl Acad Sci U S A. 1991 May 1;88(9):3952-3956.##Proc Natl Acad Sci U S A. 1993 May 15;90(10):4596-4600. "Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL.##Diamond G, Jones DE, Bevins CL." "Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.##Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene." DRAMP02903 ILGPILGLVSNALGGLL 17 Bombin H7 No entry found Not found Not found Bombina orientalis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Bacillus megaterium Bm11 (MIC=3.3 ?M);##Gram-negative bacterium: Escherichia coli D22 (MIC=3.7 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10333736 Biopolymers. 1998;47(6):435-450. "Simmaco M, Mignogna G, Barra D." Antimicrobial peptides from amphibian skin: what do they tell us? DRAMP02910 LRRIIRKIIHIIKK 14 "Ovispirin-2 (OV-2; mammals, animals)" No entry found Not found Not found Ovis aries (Sheep) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Pseudomonas aeruginosa (MIC=0.03-16 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11557478 Antimicrob Agents Chemother. 2001 Oct;45(10):2838-2844. "Saiman L, Tabibi S, Starner TD, San Gabriel P, Winokur PL, Jia HP, McCray PB Jr, Tack BF." Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis. DRAMP02911 IRRIIRKIIHIIKK 14 "Ovispirin-3 (OV-3; mammals, animals)" No entry found Not found Not found Ovis aries (Sheep) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Pseudomonas aeruginosa (MIC=1-8 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11557478 Antimicrob Agents Chemother. 2001 Oct;45(10):2838-2844. "Saiman L, Tabibi S, Starner TD, San Gabriel P, Winokur PL, Jia HP, McCray PB Jr, Tack BF." Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis. DRAMP02912 RGLRRLGRKIAHGVKKYGPTVLRIIRIAG 29 "SMAP-29 (Cathelin-related peptide SC5; Myeloid antibacterial peptide MAP-29; mammals, animals)" "P49928, P49929" Belongs to the cathelicidin family Not found Ovis aries (Sheep) "Antimicrobial, Antibacterial, Antifungal" Protein level Alpha helix Not found 1FRY resolved by NMR. "Function: Broad spectrum bactericidal agent. Biophysicochemical properties: Temperature dependence (Thermostable)." "[Ref.8549789][No NaCl]: Escherichia coli DH5a (MIC=0.1 ?M), Escherichia coli ML-35p (MIC=0.18 ?M), Pseudomonas aeruginosa PAO1 (MIC=0.17 ?M), Pseudomonas aeruginosa MR3007 (MIC=0.34 ?M), Staphylococcus aureus ATCC (MRSA) 33591 (MIC=1.24 ?M), Staphylococcus aureus 93918 (MIC=0.31 ?M).##[100 mM NaCl]: Escherichia coli DH5a (MIC=0.07 ?M), Escherichia coli ML-35p (MIC=0.12 ?M), Pseudomonas aeruginosa PAO1 (MIC=0.08 ?M), Pseudomonas aeruginosa MR3007 (MIC=0.18 ?M), Staphylococcus aureus ATCC (MRSA) 33591 (MIC=0.65 ?M), Staphylococcus aureus 93918 (MIC=0.43 ?M)." [Ref.8549789]Not found Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Outer membrane protein I (OprI) 8549789##11932493 FEBS Lett. 1995 Dec 27;377(3):519-522.##Protein Eng. 2002 Mar;15(3):225-232. "Mahoney MM, Lee AY, Brezinski-Caliguri DJ, Huttner KM.##Sawai MV, Waring AJ, Kearney WR, McCray PB Jr, Forsyth WR, Lehrer RI, Tack BF." Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide.##Impact of single-residue mutations on the structure and Function: of ovispirin/novispirin antimicrobial peptides. DRAMP02913 GLFGRLRDSLQRGGQKILEKAERIWCKIKDIFRG 34 "SMAP-34 (cathelicidin; mammals, animals)" No entry found Not found Not found Ovis aries (Sheep) "Antimicrobial, Antibacterial" Not found Not found Not found None Function: Has antibacterial activity. "[Ref.10768969][No NaCl]: Escherichia coli DH5a (MIC=0.5 M), Escherichia coli ML-35p (MIC=1.93 M), Pseudomonas aeruginosa PAO1 (MIC=0.6 M), Pseudomonas aeruginosa MR3007 (MIC=2 M), Staphylococcus aureus ATCC (MRSA) 33591 (MIC=4 M), Staphylococcus aureus 93918 (MIC=1.96 M).100 mM NaCl: Escherichia coli DH5a (MIC=0.23 M), Escherichia coli ML-35p (MIC=1.03 M), Pseudomonas aeruginosa PAO1 (MIC=0.77 M), Pseudomonas aeruginosa MR3007 (MIC=1.9 M), Staphylococcus aureus ATCC (MRSA) 33591 (MIC=13.3 M), Staphylococcus aureus 93918 (MIC=2.13 M). " [Ref.10768969]30% hemolysis at 1000 g/ml against human red blood cells. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10768969 Infect Immun. 2000 May;68(5):2748-2755. "Travis SM, Anderson NN, Forsyth WR, Espiritu C, Conway BD, Greenberg EP, McCray PB Jr, Lehrer RI, Welsh MJ, Tack BF." Bactericidal activity of mammalian cathelicidin-derived peptides. DRAMP02922 KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPK 34 "Canine beta-defensin (dogs, mammals, animals)" No entry found Not found Not found Canis lupus familiaris (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli 25922 (MIC=20 ?g/ml), Escherichia coli 700336 (MIC=50 ?g/ml);##Gram-positive bacteria: Klebsiella pneumoniae 10031 (MIC=20 ?g/ml), Listeria monocytogenes 19115 (MIC=10 ?g/ml), Staphylococcus aureus 10832 (MIC=100 ?g/ml), N. gonorrhoeae 10150 (MIC=50 ?g/ml).##Fungi: Candida albicans 14053 (MIC=50 ?g/ml), Candida albicans 11006 (MIC=5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15845463 Infect Immun. 2005 May;73(5):2611-2620. "Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T." Molecular cloning and characterization of three beta-defensins from canine testes. DRAMP02923 KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPKFQPNMLQR 42 "cBD-1 (Canine beta-defensin 1; dogs, mammals, animals)" No entry found Not found Not found Canis Lupis (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Listeria monocytogenes(MIC=6 m?g/ml), Staphylococcus aureus (MIC=100 m?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=20-25 m?g/ml), Klebsiella pneumoniae (MIC=20 m?g/ml), Neisseria gonorrhoeae (MIC=50 m?g/ml).##Yeast: Candida albicans (MIC=5-50 m?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15845463 Infect Immun. 2005 May;73(5):2611-2620. "Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T." Molecular cloning and characterization of three beta-defensins from canine testes. DRAMP18367 GFGSKPLDSFGLNFF 15 "Chaxapeptin (a class 2 lasso peptide; class 1 microcin, bacteriocins)" No entry found Not found Not found Streptomyces leeuwenhoekii Strain C58 "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Not found Not found None Fuction: No activity against the Gram-negative bacteria. It showed dose dependent inhibition of A549 cancer cells. Gram-positive bacteria: S. aureus and B. subtilis (MIC 30-35 ug/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 26402731 J Org Chem. 2015 Oct 16;80(20):10252-60. "Elsayed SS, Trusch F, Deng H, Raab A, Prokes I, Busarakam K, Asenjo JA, Andrews BA, van West P, Bull AT, Goodfellow M, Yi Y, Ebel R, Jaspars M, Rateb ME" "Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert" DRAMP18368 SMSGFSKPHD 10 "Bacteriocin TSU4 (bacteria, prokaryotes)" No entry found Not found Not found Lactobacillus animalis TSU4 "Antimicrobial, Antibacterial" Not found Not found None Only the N-terminal sequence is available. "Active against A. hydrophila, E. coli, P. aeruginosa, S. typhimurium, S. paratyphi, S. flexneri, and S. aureus (inhibition zone 25-28 mm)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 26245257 Appl Biochem Biotechnol. 2015 Sep;177(1):90-104 "Sahoo TK, Jena PK, Patel AK, Seshadri S." Purification and Molecular Characterization of the Novel Highly Potent Bacteriocin TSU4 Produced by Lactobacillus animalis TSU4 DRAMP02925 RLKELITTGGQKIGEKIRRIGQRIKDFFKNLQPREEKS 38 "Cathelicidin (dogs, mammals, animals)" No entry found Not found Not found Canis lupus familiaris (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=1.25 ?M), Klebsiella pneumoniae (MIC=1.25 ?M), Salmonella serotype Typhimurium (MIC=1.25 ?M), Pseudomonas aeruginosa (MIC=1.25 ?M), Proteus mirabilis (MIC=1.25 ?M), Salmonella serotype Enteritidis (MIC=0.5 ?M), Neisseria gonorrhoeae (MIC=0.06 ?M).##Gram-positive bacteria: Listeria monocytogenes (MIC=0.5 ?M), Staphylococcus aureus (MIC=50 ?M).##Fungi: Candida albicans (MIC=12.5-50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17462733 Dev Comp Immunol. 2007;31(12):1278-1296. "Sang Y, Teresa Ortega M, Rune K, Xiau W, Zhang G, Soulages JL, Lushington GH, Fang J, Williams TD, Blecha F, Melgarejo T." "Canine cathelicidin (K9CATH): gene cloning, expression, and biochemical activity of a novel pro-myeloid antimicrobial peptide." DRAMP02931 SPRVSRRYGRPFGGRPFVGGQFGGRPGCVCIRSPCPCANYG 41 "Arasin-likeSp (crabs, Arthropods, animals)" No entry found Not found Not found Scylla paramamosain (Mud crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus haemolyticus (MIC=6.25-12.5 ?M), Aerococcus viridans (MIC=0.19-0.39 ?M), Micrococcus luteus (MIC=0.39-0.78 ?M), Bacillus subtilis (MIC=6.25-12.5 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC>50 ?M), Aeromonas hydrophila (MIC>50 ?M), V. harveyi (MIC=0.78-1.56 ?M), Vibrio anguillarum (MIC=3.125-6.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21220028 Fish Shellfish Immunol. 2011 Feb;30(2):706-712. "Imjongjirak C, Amparyup P, Tassanakajon A." "Two novel antimicrobial peptides, arasin-likeSp and GRPSp, from the mud crab Scylla paramamosain, exhibit the activity against some crustacean pathogenic bacteria." DRAMP02932 IPAMEPAARVKRSPGYGGCSPRWACGGYG 29 "GRPSp (crabs, Arthropods, animals)" No entry found Not found Not found Scylla paramamosain (Mud crab) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus haemolyticus (MIC>50 ?M), Aerococcus viridans (MIC=6.25-12.5 ?M), Micrococcus luteus (MIC=12.5-25 ?M), Bacillus subtilis (MIC>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21220028 Fish Shellfish Immunol. 2011 Feb;30(2):706-712. "Imjongjirak C, Amparyup P, Tassanakajon A." "Two novel antimicrobial peptides, arasin-likeSp and GRPSp, from the mud crab Scylla paramamosain, exhibit the activity against some crustacean pathogenic bacteria." DRAMP02933 RRWCFRVCYRGFCYRKCR 18 "Polyphemusin-1 (PM1; crabs, Arthropods, animals)" P14215 Belongs to the tachyplesin/polyphemusin family Not found Limulus polyphemus (Atlantic horseshoe crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand (2 strands; 4 residues) "The solution structure of polyphemusin I is determined using (1)H-NMR spectroscopy. Polyphemusin I is found to be an amphipathic, beta-hairpin connected by a type I' beta-turn." 1RKK resolved by NMR. "Function: PM1 showes high antimicrobial activity against the Gram-negative, Gram-positive and fungal specimens tested. Tissue specificity: Hemocytes. PTM: Contains two disulfide bonds 4-17; 8-13 and C-terminal amidation." "Gram-negative bacteria: Escherichia coli UB1005 (MIC=0.5 ?g/ml), E. coli DC2 (MIC=1 ?g/ml), Salmonella typhimurium (defensin-sensitive) (MIC=0.25 ?g/ml), S. typhimurium (MIC=1 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), P. aeruginosa Z61 (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=1 ?g/ml), Enterococcus faecalis (MIC=1 ?g/ml).##Yeasy: Candida albicans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation "Disulfide bond between Cys4 and Cys17,Cys8 and Cys13." L No cytotoxicity information found Not found 2514185##15134657 J Biochem. 1989 Oct;106(4):663-668.##Biochim Biophys Acta. 2004 May 6;1698(2):239-250. "Miyata T, Tokunaga F, Yonega T, Yoshikawa K, Iwanaga S, Niwa M, Takao T, Shimonishi Y.##Powers JP, Rozek A, Hancock RE." "Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity.##Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I." DRAMP02934 RRWSFRVSYRGFSYRKSR 18 PM1-S (linear derivative of PM1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic No secondary structure (CD) "The CD spectra of PM1-S indicates that, in all environments (phosphate buffer, TFE, and liposomes), the peptide displays no observable patterns that could be related to structural features. This indicates that PM1-S is a flexible molecule with no favoured conformation." None Function: PM1-S remaines active against Gram-negative bacteria but displayed poor activity to both Gram-positive and fungal microorganisms. "Gram-negative bacteria: Escherichia coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=4 ?g/ml), Salmonella typhimurium (defensin-sensitive) (MIC=2 ?g/ml), S. typhimurium (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), P. aeruginosa Z61 (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=32 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeasy: Candida albicans (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15134657 Biochim Biophys Acta. 2004 May 6;1698(2):239-250. "Powers JP, Rozek A, Hancock RE." Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I. DRAMP02950 YVDREINLFDHYCIISRSPHISRWELKWQATVTCPGWTPVKGKVRGYSNPLSAEREATRDFVQRIVQRGLVTRDEASEWL 80 "PtALF5 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 5; crabs, Arthropods, ani" No entry found Not found Not found Portunus trituberculatus (Swimming Crab) "Antimicrobial, Antibacterial, Anti-Gram-" Not found Not found Not found None Contains a signal peptide and an LPS-binding Domain: (CIISRSPHISRWELKWQATVTC) and two conserved cysteine residues which can form a disulfide bridge. PtALF5 transcript in hemocytes showes a clear time-dependent response expression pattern with obvious decrease at 6 h and significant increase at 24 h. The recombinant PtALF5 has antimicrobial activity against Gram-negative bacteria Vibrio alginolyticus and Pseudomonas aeruginosa. "Gram-negative bacteria: Vibrio alginolyticus (MIC=3.89-7.78 ?M), Edwardsiella tarda (MIC=7.78-15.54 ?M), Pseudomonas aeruginosa (MIC=15.54-31.08 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 21362485##22516300 Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2012 Jul;33(1):85-91. "Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Li Q, Wang S." "Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##Molecular cloning, expression pattern and antimicrobial activity of a new isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus." DRAMP02951 MARVSLLLIVLSIALVAPSQGFLKDLLFGEAKTALLEDGTTEILDHVCNFRVMPRLRSWELYFRGDVWCPGWTVIKGESL 80 "PtALF6 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 6; crabs, Arthropods, ani" No entry found Not found Not found Portunus trituberculatus (Swimming Crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Contains a signal peptide and an LPS-binding Domain: (CNFPVMPRLRSWELYFRGDVWC) and two conserved cysteine residues which can form a disulfide bridge. "Gram-negative bacteria: Vibrio alginolyticus L59 (MIC=1.17-2.33 ?M), Pseudomonas aeruginosa P25 (MIC=9.32-18.64 ?M);##Gram-positive bacteria: Micrococcus luteus M2 (MIC=9.32-18.64 ?M), Staphylococcus aureus S7 (MIC=9.32-18.64 ?M).##Fungi: Pichia pastoris GS115 (MIC>74.57 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 21362485##23257203 Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2013 Feb;34(2):463-470. "Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Shi G." Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##A newly identified anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus with broad spectrum antimicrobial activity. DRAMP02952 MRKGVVTGLFVALVVMCLYLPQPCEAQYEALTAAILTKLSKMWHSDTLNFLGHTCHVSRTPTVKRFKLYWKGKFWCPGWA 80 "PtALF7 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 7; crabs, Arthropods, ani" No entry found Not found Not found Portunus trituberculatus (Swimming Crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Contains a signal peptide and an LPS-binding Domain: (CHVSRTPTVKRFKLYWKGKFWC) and two conserved cysteine residues which can form a disulfide bridge. "Gram-negative bacteria: Vibrio alginolyticus (MIC=0.51-1.02 ?M), Edwardsiella tarda (MIC=2.04-4.07 ?M), Pseudomonas aeruginosa (MIC=1.02-2.04 ?M);##Gram-positive bacteria: Micrococcus luteus (MIC=32.59-65.19 ?M), Staphylococcus aureus (MIC=8.15-16.30 ?M).##Fungi: Pichia pastoris (MIC>130.37 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 21362485##23261507 Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2013 Feb;34(2):652-659. "Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Shi G, Wang C." "Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##Molecular cloning, genomic structure and antimicrobial activity of PtALF7, a unique isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus." DRAMP02953 SRWPSPGRPRPFPGRPKPIFRPRPCNCYAPPCPCDRW 37 "Arasin-1 (Pro-rich, Arg-rich; crabs, Arthropods, animals)" A6XMY0 Not found Not found Hyas araneus (Great spider crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Corynebacterium glutamicum (MIC=0.8 ?M), Listonella anguillarum (MIC=6.3 ?M);##Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bond between Cys25 and Cys34,Cys27 and Cys32." L No cytotoxicity information found Not found 17658600 Dev Comp Immunol. 2008;32(3):275-285. "Stensvag K, Haug T, Sperstad S.V, Rekdal O, Indrevoll B, Styrvold O.B." "Arasin 1, a proline-arginine-rich antimicrobial peptide isolated from the spider crab, Hyas araneus." DRAMP02956 SHQDCYEALHKCMASHSKPFSCSMKFHMCLQQQ 33 Dolabellanin B2 P83376 Not found Not found Dolabella auricularia (Sea hare) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also possesses antifungal activity. PTM: Contains two disulfide bonds. Up to two of the methionines may be oxidized to methionine sulfoxides." "Gram-positive bacteria: Bacillus subtilis RIMD0225014 (MIC=2.5 ?g/ml), Staphylococcus aureus IID1677 (MRSA) (MIC=20.0 ?g/ml), Listeria monocytogenes VIU206 (MIC=40.0 ?g/ml).##Gram-negative bacteria: Haemophilus influenzae IID983 (MIC=5.0 ?g/ml), V. vulnificus RIMD2219009 (MIC=5.0 ?g/ml), Escherichia coli JM109 (MIC=20.0 ?g/ml), E. coli DH5? (MIC=40.0 ?g/ml).##Fungi: Candida albicans ATCC36232, Candida tropicalis TIMM0313, S. pombe IFO1628, Saccharomyces cerevisiae A581A." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Contains two disulfide bonds. Up to two of the methionines may be oxidized to methionine sulfoxides. L No cytotoxicity information found Not found 12590964 Dev. Comp. Immunol. 2003;27:305-311. "Iijima R, Kisugi J, Yamazaki M." A novel antimicrobial peptide from the sea hare Dolabella auricularia. DRAMP02959 RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP 39 "Antibacterial protein PR-39 (pigs, mammals, animals)" "P80054, Q9TR84" Belongs to the cathelicidin family PR39 Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Rich Not found None "Tissue specificity: Small intestine and bone marrow. PTM: Proline amide at P39." "Gram-negative bacteria: Escherichia coli K12 D21 (MIC=0.3 ?M), Escherichia coli Bd2221175 (MIC=0.3 ?M), Salmonella typhimurium LT2 (MIC=1?M), Proteus vulgaris Pvll (MIC=300 ?M), Pseudomonas aeruginosa OT97 (MIC=200 ?M), Acinetobacter calcoaceticus Acl 1 (MIC=3 ?M).##Gram-positive bacteria: Bacillus megaterium (MIC=0.3 ?M), Bacillus subtilis (MIC=15 ?M), Staphylococcus aureus (MIC=200 ?M), Streptococcus pyogenes (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1765098##7624374 Eur J Biochem. 1991 Dec 18;202(3):849-854.##Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7085-7089. "Agerberth B, Lee JY, Bergman T, Carlquist M, Boman HG, Mutt V, J?rnvall H.##Gudmundsson GH, Magnusson KP, Chowdhary BP, Johansson M, Andersson L, Boman HG." "Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides.##Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39." DRAMP02960 RIIDLLWRVRRPQKPKFVTVWVR 23 "Antibacterial peptide PMAP-23 (Myeloid antibacterial peptide 23; pigs, mammals, animals)" P49930 Belongs to the cathelicidin family PMAP23 Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Alpha helix Not found None "Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PTM: Contains two disulfide bonds (By similarity)." "Gram-negative bacteria: Escherichia coli ML35 (MIC=2 ?M), Escherichia coli ATCC 25922 (MIC=4 ?M), Salmonella typhimurium ATCC 14028 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=16 ?M).##Gram-positive bacteria: Bacillus megaterium (MIC=2 ?M), Staphylococcus aureus ATCC 25923 (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 8132502 J Biol Chem. 1994 Mar 18;269(11):7855-7858. "Zanetti M, Storici P, Tossi A, Scocchi M, Gennaro R." Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells. DRAMP02961 GLLSRLRDFLSDRGRRLGEKIERIGQKIKDLSEFFQS 37 "Antibacterial peptide PMAP-37 (Myeloid antibacterial peptide 37; pigs, mammals, animals)" P49932 Belongs to the cathelicidin family PMAP37 Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Alpha helix Not found None "Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria with minimal inhibitory concentrations ranging over 1-4 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PTM: Contains two disulfide bonds (By similarity)." "Gram-negative bacteria: Escherichia coli ML35 (MIC=2 ?M), Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli D21 (MIC=2 ?M), Salmonella typhimurium ATCC 14028 (MIC=4 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=2 ?M).##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=4 ?M), Bacillus megaterium local isolate (IC=4 ?M), Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan 1 (MIC=64 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 7737198 Eur J Biochem. 1995 Mar 15;228(3):941-946. "Tossi A, Scocchi M, Zanetti M, Storici P, Gennaro R." "PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity." DRAMP02228 SMLSVLKNLGKVGLGFVACKINKQC 25 "RANATUERIN 1 (Frogs, amphibians, animals)" P82741 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None Function: Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. Has activity against C.albicans. Has no detectable hemolytic activity. [Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Yeast: Candida albicans (MIC=70 ?M). [Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20?g/ml against human red blood cell. Cyclic Free Cyclization (Cys19 and Cys25) Disulfide bond between Cys19 and Cys25. L No cytotoxicity information found Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02963 GRFRRLRKKTRKRLKKIGKV 20 PMAP-36(1-20) No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6 ?M), Bacillus megaterium Bm11 (MIC=3 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12 ?M), E. coli ML35 (MIC=12 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=48 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=3 ?M).##Fungi: Candida albicans c.i. (MIC>64 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02964 GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLG 34 PMAP-36(1-34) No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1 ?M), S. aureus 710A (MIC=2 ?M), S. aureus SA-62 (MRSA) (MIC=4 ?M), Bacillus megaterium Bm11 (MIC=1 ?M), S. epidermidis ATCC 12228 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), E. coli ML35 (MIC=1 ?M), E. coli D21 (MIC=1 ?M), E. coli D22 (MIC=0.5 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 ?M), S. enterica ser. Enteritidis H2 (MIC=1 ?M), P. aeruginosa ATCC 27853 (MIC=1 ?M), S. marcescens ATCC 8100 (MIC=2 ?M).##Fungi: Candida albicans c.i. (MIC=8 ?M), Cryptococcus neoformans c.i.(MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02965 GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLGC 35 PMAP-36(1-35)2 No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), S. aureus 710A (MIC=2 ?M), S. aureus SA-62 (MRSA) (MIC=4 ?M), Bacillus megaterium Bm11 (MIC=1 ?M), S. epidermidis ATCC 12228 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), E. coli ML35 (MIC=0.5 ?M), E. coli D21 (MIC=0.5 ?M), E. coli D22 (MIC=0.5 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 ?M), S. enterica ser. Enteritidis H2 (MIC=0.5 ?M), P. aeruginosa ATCC 27853 (MIC=1 ?M), S. marcescens ATCC 8100 (MIC=2 ?M).##Fungi: Candida albicans c.i. (MIC=16 ?M), Cryptococcus neoformans c.i.(MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02966 KQATVGDINTERPGILDLKGKAKWDAWNGLKGTSKEDAMKAYINKVEELKKKYGI 55 "DBI(32-86) (pigs, mammals, animals)" "P12026, A7YB23, Q9TSG2" Belongs to the ACBP family DBI Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: DBI(32-86) has antibacterial properties. Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.69 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8375398##3289918 Eur J Biochem. 1993 Sep 1;216(2):623-629.##Eur J Biochem. 1988 Jun 1;174(2):239-245. "Agerberth B, Boman A, Andersson M, J?rnvall H, Mutt V, Boman HG.##Chen ZW, Agerberth B, Gell K, Andersson M, Mutt V, Ostenson CG, Efendi? S, Barros-S?derling J, Persson B, J?rnvall H." "Isolation of three antibacterial peptides from pig intestine: gastric inhibitory polypeptide (7-42), diazepam-binding inhibitor (32-86) and a novel factor, peptide 3910.##Isolation and characterization of porcine diazepam-binding inhibitor, a polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release." DRAMP02970 RGGRLCYCRRRFCVCVGR 18 "Protegrin-1 (Protegrin 1; PG-1; pigs, mammals, animals)" P32194 Belongs to the cathelicidin family NPG1 Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Beta strand Not found 1PG1 resolved by NMR. The sequence of IB-367 is RGGLCYCRGRFCVCVGR and the peptide is active against bacteria and fungi. This peptide showed synergistic effect with LL-37 against P. aeruginosa and E. coli (Yan H & Hancock REW 2001 Antimicrob Agents Chemother 45: 1558-60). PG-1 derivatives were subjected to clinical trials. "Gram-negative bacteria: Escherichia coli (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=64 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bond between Cys6 and Cys15,Cys8 and Cys13." L "[Ref.31399625] Cytotoxicity: 661W cells(IC50=353.470.5M), HEK293T cells(IC50=276054.1M), NIH-3T3 cells(IC50=719.259.5M), SH-SY5Y cells(IC50=590.458.2M), PMN cells(IC50=948.964.1M), and 3D4/2 cells(IC50=391.171.3M)" Cell membrane 8647100 Chem Pharm Bull (Tokyo). 1995 May;43(5):853-858. "Tamamura H, Murakami T, Horiuchi S, Sugihara K, Otaka A, Takada W, Ibuka T, Waki M, Yamamoto N, Fujii N." Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity. DRAMP02975 VRRFPWWWPFLRR 13 "Tritrpticin (Trp-rich; pigs, mammals, animals)" No entry found Belongs to the cathelicidin family Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix (1 helices; 3 residues) Not found 1D6X resolved by NMR. Function: Tritrpticin has strong antimicrobial activity with a wide spectrum. "Gram-negative bacteria: Escherichia coli (5 mm), Pseudomonas aeruginosa (3 mm), Klebsiella pneumonia (7 mm), Proteus mirabilis (1 mm);##Gram-positive bacteria: Staphylococcus epidermidis (5 mm), Streptococcus group D (4 mm). [inhibit zones in mm]##Fungi: Aspergillus fumigatus (MIC=250 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8706838##10606506 FEBS Lett. 1996 Jul 15;390(1):95-98.##Biochemistry. 1999 Dec 21;38(51):16749-55. "Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K.Schibli DJ, Hwang PM, Vogel HJ.##Schibli DJ, Hwang PM, Vogel HJ." Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides.##Structure of the antimicrobial peptide tritrpticin bound to micelles: a distinct membrane-bound peptide fold. DRAMP02980 GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE 78 "Antimicrobial peptide NK-lysin (NKL; pigs, mammals, animals)" Q29075 Not found NKL Sus scrofa (Pig) "Antimicrobial, Antibacterial, Antifungal, Antitumor" Protein level Alpha helix Not found 1NKL resolved by NMR. "Function: May be an effector molecule of cytotoxic activity. High activity against E. coli and B. megaterium, moderate against A. calcoaceticus and S. pyogenes. Has some antifungal activity against Candida albicans. Tissue specificity: Cytotoxic T and NK cells. Induction: By interleukin-2. PTM: Contains three disulfide bonds 4-76; 7-70; 35-45." "[with medium E]: Escherichia coli D21 (MIC=0.5 ?M), Escherichia coli Bd2221/75 (MIC=10 ?M), Acinetobacter calcoaceticus Ac 11 (MIC=7 ?M), Bacillus megaterium Bmll (MIC=1.6 ?M);##[without medium E]: Escherichia coli D21 (MIC=8 ?M), Escherichia coli Bd2221/75 (MIC=39 ?M), Bacillus megaterium Bmll (MIC=0.8 ?M), Streptococcus pyogenes w.t. (MIC=34 ?M), Candida albicans w.t. (MIC=31 ?M)." [Ref.7737114] It exhibits no hemolytic activity at 170 ?M against sheep red blood cells. Cyclic Free Free Disulfide bonds between Cys4 and Cys76; Cys7 and Cys70; Cys35 and Cys45. L "[Ref.7737114] NK-lysin at 50g/ml was able to give 90% lysis of 5'Cr-labelled YAC-1 cells in a medium with 2% fetal calf serum(FCS) and 75% lysis in phosphate-buffered saline(PBS), 15% lysis suspended in medium E." Lipopolysaccharide (LPS)-binding 7737114##9334742 EMBO J. 1995 Apr 18;14(8):1615-1625.##Nat Struct Biol. 1997 Oct;4(10):793-795. "Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, J?rnvall H, Mutt V, Olsson B, Wigzell H, et al.##Liepinsh E, Andersson M, Ruysschaert JM, Otting G." "NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.##Saposin fold revealed by the NMR structure of NK-lysin." DRAMP03028 IDWKKLLDAAKQIL 14 Polybia-MP1 No entry found Not found Not found Polybia paulista "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. "[Ref.29075946] Gram-positive bacterium: Bacillus subtilis (MIC=12.5M), Staphylococcus aureus (MIC=18.8M);##Gram-negative bacterium:Escherichia coli (MIC=75M), Shigella dysenteriae (MIC=75M), Klebsiella pneumoniae (MIC=37.5M)" "[Ref.29075946] <1% hemolysis at 12.5M, 3.2% hemolysis at 25M against human red blood cells." stapled peptide Free Amidation tethers Lys6 and Arg10 L No cytotoxicity information found Not found 29075946 Arch Pharm Res. 2017 Dec;40(12):1414-1419. "Luong HX, Kim DH, Lee BJ, Kim YW" Antimicrobial activity and stability of stapled helices of polybia-MP1 DRAMP03721 ILGKIWEGIKSLF 13 IsCT1 Q8MMJ7 Belongs to the scorpion NDBP 5 family Not found Opisthacanthus madagascariensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix "Residue 6 is important for antibacterial activity, and hemolysis activity" None Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. "[Ref.28657596] Gram-positive bacterium:Staphylococcus aureus (MIC=50g/mL);##Gram-negative bacterium: S. typhimurium (MIC=100g/mL), Escherichia coli (MIC=50g/mL)" "[Ref.28657596] 2% hemolysis at 10 g/ml, 96% hemolysis at 50 g/ml against human red blood cells." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 28657596 Antibiotics (Basel). 2017 Jun 28;6(3). pii: E13. "de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM." Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides DRAMP01377 FMPILSCSRFKRC 13 "Odorranain-G1 (OdG1; Frogs, amphibians, animals)" "A6MBL7, A6MBL8" Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-G1 adopts 44.1% -sheet structure in water solution. None Function: Odorranain-G1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 g/ml), Bacillus subtilis (MIC=37.5 g/ml).##Yeast: Candida albicans (MIC=1.10 g/ml)." [Ref:17272268] It has no hemolytic activity against rabbit red blood cells Cyclic Free Cyclization (Cys7 and Cys13) Disulfide bond between Cys7 and Cys13. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02995 QERGSIVIQGTKEGKSRPSLDIDYKQRVYDKNGMTGDAYGGLNIRPGQPSRQHAGFEFGKEYKNGFIKGQSEVQRGPGGRLSPYFGINGGFRF 93 "Hymenoptaecin (Insects, animals)" Q10416 Not found Not found Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli K514 (MIC=0.5-1 ?M), E. coli K514 anaerobic, E. coli NCTC9001 (MIC=1-5 ?M), Xanthomonas campestris (MIC=0.5-1 ?M), Pseudomonas solanacearum (MIC>10 ?M), Erwinia carotovora ssp.(MIC=1-5 ?M);##Gram-positive bacteria: Micrococcus lysodeikticus (MIC=1-5 ?M), Bacillus megaterium (MIC=0.5-1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8463238 J Biol Chem. 1993 Apr 5;268(10):7044-7054. "Casteels P, Ampe C, Jacobs F, Tempst P." "Functional and chemical characterization of Hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera)." DRAMP02996 GNNRPIYIPQPRPPHPRL 18 "Apidaecin-2 (Apidaecin II; Insects, animals)" "Q06601, P11525, P11526, P11527" Belongs to the apidaecin family APID14 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 ?g/ml), Erwinia salicis (MIC=0.02 ?g/ml), Escherichia coli (MIC=0.2 ?g/ml), Pseudomonas syringae (MIC=0.1 ?g/ml), Rhizobium meliloti (MIC=0.02 ?g/ml), Salmonella Newport (MIC=0.2 ?g/ml), Salmonella typhimurium (MIC=0.1 ?g/ml);##Gram-positive bacteria: Shigella flexneri (MIC=0.1 ?g/ml), Corynebacterium insidiosum (MIC=100 ?g/ml), Bacillus megaterium (MIC=100 ?g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2676519 EMBO J. 1989 Aug;8(8):2387-2391. "Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P." Apidaecins: antibacterial peptides from honeybees. DRAMP02441 VXLFPVXLFP 10 Gramicidin S No entry found Not found Not found Bacillus brevis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Beta sheet and beta-turn The peptide have the C2-symmetrical sequence [cyclo-(Val-Orn-Leu-D-Phe-Pro)2]. The two sequences Val-Orn-Leu form an antiparallel None Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. "[Ref.29499484] Gram-positive bacterium:Staphylococcus aureus subsp.aureus CIP 4.83 ATCC 6538 (MIC=3.125g/mL),Bacillus subtilis subsp. subtilis CIP 52.65 (MIC=3.125g/ml),Enterococcus faecalis CIP 103015 (MIC=3.125g/ml),Enterococcus faecalis CIP 103214 (MIC=3.125g/ml),Bacillus cereus CIP 66.24 (MIC=6.25g/ml),Streptococcus salivarius CIP 102503 (MIC=3.125g/ml),Enterococcus faecium CIP 103014 (MIC=3.125g/ml);##Gram-negative bacterium:Escherichia coli CIP 53.126 ATCC 8739 (MIC=12.5g/ml),Pseudomonas aeruginosa CIP 82.118 ATCC 9027 (MIC>=100g/ml)" "[Ref.29499484] It has 74% hemolysis at 50g/ml, 83% hemolysis at 100g/ml against human red blood cells." Cyclic No specific N-terminal No specific C-terminal The 'O' in sequence is Ornithine Mixed(D-Phe) No cytotoxicity information found Not found 29499484 Eur J Med Chem. 2018 Apr 10;149:122-128. "Wan Y, Stanovych A, Gori D, Zirah S, Kouklovsky C, Alezra V." ",-diamino acids as building blocks for new analogues of Gramicidin S: Synthesis and biological activity" DRAMP02998 GNNRPVYIPQPRPPHPRI 18 "Apidaecin-1A (Apidaecin IA; Insects, animals)" "Q06602, P11525, P11526" Belongs to the apidaecin family APID73 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 ?g/ml), Erwinia salicis (MIC=0.02 ?g/ml), Escherichia coli (MIC=0.1 ?g/ml), Pseudomonas syringae (MIC=0.2 ?g/ml), Rhizobium meliloti (MIC=0.1 ?g/ml), Salmonella Newport (MIC=0.2 ?g/ml), Salmonella typhimurium (MIC=0.1 ?g/ml), Shigella flexneri (MIC=0.1 ?g/ml);##Gram-positive bacteria: Corynebacterium insidiosum (MIC=50 ?g/ml), Bacillus megaterium (MIC=150 ?g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2676519 EMBO J. 1989 Aug;8(8):2387-2391. "Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P." Apidaecins: antibacterial peptides from honeybees. DRAMP02999 PFKISIHL 8 "Jellein-1 (Jelleine-I; chain of Major royal jelly protein 1; Insects, animals)" "O18330, Q548D6" Belongs to the major royal jelly protein family MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-1 has antibacterial and antifungal activity. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. Developmental stage: Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee. Miscellaneous: Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival. Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days. PTM: Histidine amide at H7." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=10 ?g/ml), S. saprophyticus (MIC=15 ?g/ml), Bacillus subtilis CCT 2471 (MIC=10 ?g/ml).##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=2.5 ?g/ml), Enterobacter cloacae ACCT 23355 (MIC=10 ?g/ml), Klebsiella pneumoniae ACCT 13883 (MIC=10 ?g/ml), Pseudomonas aeruginosa ACCT 27853 (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=2.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237##9395329##21516106 Peptides. 2004 Jun;25(6):919-928.##Eur J Biochem. 1997 Nov 1;249(3):797-802.##Nature. 2011 May 26;473(7348):478-483. "Fontana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS.##Ohashi K, Natori S, Kubo T.##Kamakura M." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).##Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.##Royalactin induces queen differentiation in honeybees. DRAMP03000 TPFKISIHL 9 "Jellein-2 (Jelleine-II; chain of Major royal jelly protein 1; Insects, animals)" "O18330, Q548D6" Belongs to the major royal jelly protein family MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-2 has antibacterial and antifungal activity. Jellein-2 is probably processed to yield jellein-1 and jellein-4. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. Developmental stage: Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee. Miscellaneous: Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival. Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days. PTM: Leucine amide at L9." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=15 ?g/ml), S. saprophyticus (MIC=10 ?g/ml), Bacillus subtilis CCT 2471 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=15 ?g/ml), Enterobacter cloacae ACCT 23355 (MIC=15 ?g/ml), Klebsiella pneumoniae ACCT 13883 (MIC=15 ?g/ml), Pseudomonas aeruginosa ACCT 27853 (MIC=15 ?g/ml).##Yeast: Candida albicans (MIC=2.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237##9395329##21516106 Peptides. 2004 Jun;25(6):919-928.##Eur J Biochem. 1997 Nov 1;249(3):797-802.##Nature. 2011 May 26;473(7348):478-483. "Fontana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS.##Ohashi K, Natori S, Kubo T.##Kamakura M." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).##Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.##Royalactin induces queen differentiation in honeybees. DRAMP03001 EPFKISIHL 9 "Jellein-3 (Jelleine-III; Insects, animals)" P84759 Not found MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-3 has antibacterial and antifungal activity. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. PTM: Leucine amide at L9." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=30 ?g/ml), S. saprophyticus (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT1371 (MIC=15 ?g/ml), Enterobacter cloacae ATCC 23355, Klebsiella pneumoniae ATCC 13883, Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?g/ml).##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237 Peptides. 2004 Jun;25(6):919-928. "ntana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera). DRAMP03057 GSKKPVPIIYCNRRTGKCQRM 21 "Thanatin(insects, arthropods, invertebrates, animals)" P55788 Not found Not found Podisus maculiventris "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand "Contain C-terminally a loop of 6 residues, delineated by an intramolecular disulfide bridge. This loop carries a strong positive charge in both molecules and contains a central threonine residue, which separates two subgroups of electropositivity." 8TFV Function: Insect defense peptide with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and fungi. No activity against S.aureus. Stops respiration in bacteria but does not permeabilize their inner membranes. Has no detectable hemolytic activity. "[Ref.8577744] Gram-positive bacteria: Aerococcus viridans (MIC=0.6-1.2 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Bacillus subtilis (MIC=2.5-5 ?M), Pediococcus acidilactici (MIC=20-40 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.3-0.6 ?M), Escherichia coli D31 (MIC=0.3-0.6 ?M), Escherichia coli 1106 (MIC=0.6-1.2 ?M), Salmonella typhimurium (MIC=0.6-1.2 ?M), Klebsiella pneumoniae (MIC=0.6-1.2 ?M), Enterobacter cloacae (MIC=1.2-2.5 ?M), Erwinia carotovora (MIC=10-20 ?M), Pseudomonas aeruginosa (MIC=20-40 ?M);##Fungi: Neurospora crassa (MIC=0.6-1.2 ?M), Botrytis cinerea (MIC=1.2-2.5 ?M), Nectria haematococca (MIC=1.2-2.5 ?M), Trichoderma viride (MIC=1.2-2.5 ?M), Alternaria brassicicola (MIC=2.5-5 ?M), Fusarium culmorum (MIC=2.5-5 ?M), Ascochyta pisi (MIC=5-10?M), Fusarium oxysporum (MIC=10-20 ?M)." [Ref.8577744] It exhibits no hemolytic activity at 40 ?M against porcine erythrocytes. Cyclic Free Free Disulfide bond between Cys11 and Cys18. L No cytotoxicity information found Not found 8577744##9760181 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.##Eur J Biochem. 1998 Sep 1;256(2):404-410. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA.##Mandard N, Sodano P, Labbe H, Bonmatin JM, Bulet P, Hetru C, Ptak M, Vovelle F." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.##Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data." DRAMP03003 GFLSILKKVLPKVMAHMK 18 "Melectin (MEP; Insects, animals)" P86170 Not found Not found Melecta albifrons (Cuckoo bee) (Melecta punctata) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacteria as well as Gram-negative bacteria. Stimulates degranulation from rat peritoneal mast cells with an EC50 of 19.4 ?M. Has weak hemolytic activity towards rat erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." "[Ref.18942691]Gram-positive bacteria: Bacillus subtilis (MIC=0.8 ?M), Staphylococcus aureus (MIC=6.8 ?M);##Gram-negative bacteria: Escherichia coli (MIC=2.0 ?M), Pseudomonas aeruginosa (MIC=18.5 ?M)." [Ref.18942691]LC50>100 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18942691 Chembiochem. 2008 Nov 24;9(17):2815-2821. "Cerovsk? V, Hovorka O, Cvacka J, Voburka Z, Bednrov L, Borovickov L, Slaninov J, Fuck V." Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons. DRAMP03007 GFLSALKKYLPIVLKHV 17 "Osmin (Insects, animals)" P0CD70 Not found Not found Osmia rufa (Red mason bee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (CD) "In absence of TFE, the spectrum shows a random coil type structure. When increasing the concentration of TFE from 0 to 20%, a transition into an -helix structure is observed." None "Function: Synthetic peptide exhibits hemolytic activity to human erythrocytes and inhibits bacterial and fungal growth at micromolar concentrations. A synthetic peptide with a free C-terminus shows weaker hemolytic (5.0 HU/mg), antibacterial and antifungal activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." [Ref.19109988]Gram-positive bacterium: Micrococcus luteus (MIC=1.56-0.78 ?M);##Gram-negative bacterium: Escherichia coli SBS363 (MIC=3.125-1.56 ?M);##fungi: Fusarium oxysporum (MIC=0.78-0.39 ?M). [Ref.19109988]5.0 HU/mg hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19109988 Toxicon. 2010 Jan;55(1):20-27. "?cklin R, Favreau P, Thai R, Pflugfelder J, Bulet P, Mebs D." Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (hymenoptera: megachilidae). DRAMP03019 INWLKLGKKILGAL 14 Mastoparan PDD-B No entry found Belongs to the mastoparan family Not found Polistes dorsalis dorsolis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. PDD-B has hemolytic activity. [Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=70 ?M);##Gram-negative bacterium: Escherichia coli (MIC=15.5 ?M). [Ref.18375018]IC50=45 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18375018 Peptides. 2008 Jun;29(6):992-1003. "Cerovsk? V, Slaninov J, Fuck V, Hulacov H, Borovickov L, Jezek R, Bednrov L." New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs. DRAMP03020 INWKKIFEKVKNLV 14 Mastoparan PDD-A No entry found Belongs to the mastoparan family Not found Polistes dorsalis dorsolis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. PDD-A shows little hemolytic activity. [Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=11.8 ?M);##Gram-negative bacterium: Escherichia coli (MIC=7.5 ?M). [Ref.18375018]IC50>100 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18375018 Peptides. 2008 Jun;29(6):992-1003. "Cerovsk? V, Slaninov J, Fuck V, Hulacov H, Borovickov L, Jezek R, Bednrov L." New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs. DRAMP03021 INWKKIASIGKEVLKAL 17 Mastoparan PMM No entry found Belongs to the mastoparan family Not found Polistes major major "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. Shows hemolytic activity. [Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=7.3 ?M);##Gram-negative bacterium: Escherichia coli (MIC=25.8 ?M). [Ref.18375018]IC50=80 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18375018 Peptides. 2008 Jun;29(6):992-1003. "Cerovsk? V, Slaninov J, Fuck V, Hulacov H, Borovickov L, Jezek R, Bednrov L." New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs. DRAMP03022 INWLKLGKKMMSAL 14 Mastoparan MP No entry found Belongs to the mastoparan family Not found Mischocyttarus phthisicus "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Function: Has antibacterial activity. Has hemolytic activity. [Ref.18375018]Gram-positive bacterium: Bacillus subtilis (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli (MIC=65 ?M). [Ref.18375018]IC50=100 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18375018 Peptides. 2008 Jun;29(6):992-1003. "Cerovsk? V, Slaninov J, Fuck V, Hulacov H, Borovickov L, Jezek R, Bednrov L." New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs. DRAMP01739 LLPIVGNLLKSLL 13 "Temporin-B (Frogs, amphibians, animals)" P79874 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found 6GIL resolved by NMR. "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has hemolytic activity. PTM: Leucine amide at position 13. Tissue specificity: Expressed by the skin glands." "[Ref.9022710] Gram-positive bacteria: Bacillus megaterium BM11 (LC=2.8 ?M), Staphylococcus aureus Cowanl (LC=6.0 ?M), Streptococcus pyogenes betahemolytic group A (LC=7.0 ?M);##Gram-negative bacteria: Escherichia coli D21(LC=21.0 ?M), Escherichia coli D21e7 (LC=13.2 ?M), Escherichia coli D21f1 (LC=10.0 ?M), Escherichia coli D21f2 (LC=3.3 ?M), Escherichia coli D22 (LC=11.2 ?M),Yersinia pseudotuberculosis (LC=7.0 ?M), Pseudomonas aeruginosa ATCC15692 (LC>360 ?M);##Yeast: Candida albicans (LC=4.0 ?M).(LC: Lethal concentration).##[Ref.28443279] Gram-positive bacterium: S.aureus ATCC 33591 (MIC=12M), Staphylococcus epidermidis (MIC=6M);##Gram-negative bacterium: Klebsiella pneumoniae ATCC BAA-1706 (MIC=48M), Pseudomonas aeruginosa ATCC 27853 (MIC=48M)" [Ref.9022710] LC>120 ?M against Human red blood cells. (LC: Lethal concentration)##[Ref.28443279] 1% hemolysis at 96M against human red blood cells. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9022710##28443279 Eur J Biochem. 1996 Dec 15;242(3):788-792.##Front Chem. 2017 Apr 11;5:24. "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.##Grassi L, Maisetta G, Maccari G, Esin S, Batoni G." "Temporins, antimicrobial peptides from the European red frog Rana temporaria.##Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide" DRAMP03033 INWKGIAAMAKKLL 14 "Mastoparan-like peptide 12a (Insects, animals)" P0C1M4 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide. Has little hemolytic activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " [Ref.17046111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 ?g/ml);##Fungi: Candida albicans ATCC 2002 (MIC=3.7 ?g/ml). [Ref.16330062]Little hemolytic activity at 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062##17046111 Toxicon. 2006 Feb;47(2):249-253.##Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.##Xu X, Yang H, Yu H, Li J, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom.##The mastoparanogen from wasp. DRAMP03034 INWKGIAAMKKLL 13 "Mastoparan-like peptide 12b (Insects, animals)" P0C1M5 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide. Has little hemolytic activity. Shows antimicrobial activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L13)." [Ref.16330062]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 ?g/ml);##Fungi: Candida albicans ATCC 2002 (MIC=7.5 ?g/ml). [Ref.16330062]Little hemolytic activity at 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. Epub 2005 Dec 5. Peptides. 2006 Dec;27(12):3053-7. Epub 2006 Oct 13. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.Xu X, Yang H, Yu H, Li J, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venomThe mastoparanogen from wasp. DRAMP03035 INLKAIAALAKKLLG 15 "Mastoparan-like peptide 12c (Insects, animals)" A0SPI0 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows mast cell degranulation and antimicrobial activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.0 ?g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=12.0 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17046111 Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Yang H, Yu H, Li J, Lai R." The mastoparanogen from wasp. DRAMP03036 INLKAIAAMAKKLL 14 "Mastoparan-like peptide 12d (Insects, animals)" P0C5G7 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows mast cell degranulation and antimicrobial activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=1.5 ?g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=12.0 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17046111 Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Yang H, Yu H, Li J, Lai R." The mastoparanogen from wasp. DRAMP03037 LNLKGIFKKVASLLT 15 "Eumenitin (Er-12; Insects, animals)" P0C931 Not found Not found Eumenes rubronotatus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Cationic linear alpha-helical antimicrobial peptide that binds preferentially to charged lipid membranes as compared with zwitterionic ones. It exhibits inhibitory activity against both Gram-positive and Gram-negative bacteria, and moderately stimulates degranulation from the rat peritoneal mast cells. Does not show hemolytic activity. May play a role in preventing infection by microorganisms during prey consumption by their larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16762455]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC>60 ?M), Staphylococcus aureus ATCC 25923 (MIC=6 ?M), Staphylococcus saprophytius (CS) (MIC=6 ?M), Staphylococcus epidermius (CS) (MIC>60 ?M), Bacillus subtilis CCT 2471 (MIC=60 ?M), Bacillus thuringiensis (WT) (MIC>60 ?M);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=6 ?M), Escherichia coli ATCC 25922 (MIC=6 ?M), Escherichia cloacae ATCC 23355 (MIC>60 ?M), Proteus mirabilis (CS) (MIC>60 ?M), Pseudomonas aeruginosa ATCC 15442 (MIC=30 ?M)." [Ref.16762455]Non-hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 16762455##18206199 Peptides. 2006 Nov;27(11):2624-2631.##Toxicon. 2008 Apr;51(5):736-745. "Konno K, Hisada M, Naoki H, Itagaki Y, Fontana R, Rangel M, Oliveira JS, Cabrera MP, Neto JR, Hide I, Nakata Y, Yasuhara T, Nakajima T.##Arcisio-Miranda M, dos Santos Cabrera MP, Konno K, Rangel M, Procopio J." "Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus.##Effects of the cationic antimicrobial peptide eumenitin from the venom of solitary wasp Eumenes rubronotatus in planar lipid bilayers: surface charge and pore formation activity." DRAMP03038 LNLKGLIKKVASLLN 15 "Eumenitin-R (Insects, animals)" P0CJ36 Not found Not found Eumenes rubrofemoratus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=60 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=15 ?M), Streptococcus pyogenes (clinical sample) (MIC=15 ?M), Bacillus subtilis ATCC 6633 (MIC=7.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 ?M);##Fungi: Candida albicans ATCC 90112 (MIC<7.5 ?M)." [Ref.21549739]EC50=530.3 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03039 LNLKGLFKKVASLLT 15 "Eumenitin-F (Insects, animals)" P0CJ37 Not found Not found Eumenes fraterculus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>60 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=30 ?M), Streptococcus pyogenes (clinical sample) (MIC=30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC>60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=353.4 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03040 FDVMGIIKKIAGAL 14 "Eumenine mastoparan-EF (EMP-EF; Insects, animals)" P0CJ39 Not found Not found Eumenes fraterculus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=30 ?M), Streptococcus pyogenes (clinical sample) (MIC>30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=181.1 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03041 FDIMGLIKKVAGAL 14 "Eumenine mastoparan-ER (EMP-ER; Insects, animals)" P0CJ38 Not found Not found Eumenes rubrofemoratus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC>30 ?M), Streptococcus pyogenes (clinical sample) (MIC>30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=200 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03042 INLLKIAKGIIKSL 14 "Eumenine mastoparan-AF (EMP-AF; Af-113; Insects, animals)" P0C022 Not found Not found Anterhynchium flavomarginatum micado (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Alpha helix Not found None "Function: Mast cell degranulating peptide. Also permeates anionic liposomes. Has hemolytic activity. Has an amphiphilic alpha-helix conformation. Shows broad-spectrum antimicrobial activity. Blocks the lobster neuromuscular transmission. Induces the depolarization of the muscle membrane. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.15317499]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC=5 ?g/ml), S. saprophyticus CS (MIC=5 ?g/ml), S. epidermidis CS (MIC=5 ?g/ml), Bacillus subtilis CCT 2471 (MIC=40 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=20 ?g/ml), Escherichia coli ATCC 25922 (MIC=50 ?g/ml), Pseudomonas aeruginosa ATCC 15442 (MIC=20 ?g/ml)." [Ref.10775751]100% hemolytic activity against human erythrocytes at 10^-4 M Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 15317499##11006592##10775751 J Pept Res. 2004 Sep;64(3):95-103.##Rapid Commun Mass Spectrom. 2000;14(19):1828-1834.##Toxicon. 2000 Nov;38(11):1505-1015. "dos Santos Cabrera M.P, de Souza B.M, Fontana R, Konno K, Palma M.S, de Azevedo W.F. Jr, Neto J.R.##Hisada M, Konno K, Itagaki Y, Naoki H, Nakajima T.##Konno K, Hisada M, Naoki H, Itagaki Y, Kawai N, Miwa A, Yasuhara T, Morimoto Y, Nakata Y." "Conformation and lytic activity of eumenine mastoparan: a new antimicrobial peptide from wasp venom.##Advantages of using nested collision induced dissociation/post-source decay with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: sequencing of novel peptides from wasp venom.##Structure and biological activities of eumenine mastoparan-AF (EMP-AF), a new mast cell degranulating peptide in the venom of the solitary wasp (Anterhynchium flavomarginatum micado)." DRAMP03043 INWLKLGKAIIDAL 14 "Agelaia-mastoparan (Agelaia-MP; Insects, animals)" P69436 Not found Not found Agelaia pallipes pallipes (Neotropical social wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Hemolytic mast cell degranulator, presenting no antimicrobial action and no chemotaxis for polymorphonucleated leukocytes (PMNL). Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.15225564]Gram-negative bacteria: Escherichia coli (MIC=382 ?g/ml), Pseudomonas aeruginosa (MIC=257 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=237 ?g/ml), Staphylococcus aureus (MIC=191 ?g/ml)." [Ref.15225564]70% hemolytic activity at 156 ng/ml against rat erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15225564##15052574 Toxicon. 2004 Jul;44(1):67-74.##Rapid Commun Mass Spectrom. 2004;18(6):636-642. "Mendes MA, de Souza BM, Marques MR, Palma MS.##Mendes MA, Monson de Souza B, Delazari dos Santos L, Palma MS." Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes.##Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. DRAMP03044 ILGTILGLLKGL 12 "Protonectin (Agelaia-chemotactic peptide, Agelaia-CP; Insects, animals)" P69437 Not found Not found Agelaia pallipes pallipes (Neotropical social wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Mast cell degranulator that induces a potent chemotaxis in polymorphonucleated leukocyte (PMNL) cells. Shows potent antimicrobial action against both Gram-positive and Gram-negative bacteria. Shows no hemolytic activity. "[Ref.15225564]Gram-negative bacteria: Escherichia coli (MIC=25 ?g/ml), Pseudomonas aeruginosa (MIC=1.7 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=3.1 ?g/ml), Staphylococcus aureus (MIC=12.5 ?g/ml)." [Ref.15052574]Non-hemolytic activity against rat red blood cell Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15225564##15052574 Toxicon. 2004 Jul;44(1):67-74.##Rapid Commun Mass Spectrom. 2004;18(6):636-642. "Mendes MA, de Souza BM, Marques MR, Palma MS.##Mendes MA, Monson de Souza B, Delazari dos Santos L, Palma MS." Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes.##Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. DRAMP03045 VTCELLMFGGVVGDSACAANCLSMGKAGGSCNGGLCDCRKTTFKELWDKRFG 52 "Defensin-NV (Insects, animals)" No entry found Not found Not found Nasonia vitripennis (Ectoparasitic wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Bridge Not found None "Function: Defensin-NV had little hemolytic activity to rabbit red blood cells and has antimicrobial activity against Gram-positive, Gram-negative bacteria, and Fungi." "[Ref.20362606]Gram-positive bacteria: Staphylococcus aureus (MIC=0.93 ?M), Bacillus cereus (MIC=0.93 ?M), B. dysenteriae (MIC=0.46 ?M);##Gram-negative bacteria: Escherichia coli (MIC=1.86 ?M), Pseudomonas aeruginosa (MIC=9.3 ?M).##Yeast: Candida albicans (MIC=1.86 ?M)." [Ref.20362606]5% hemolytic activity at 200 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20362606 Toxicon. 2010 Aug 1;56(1):101-106. "Ye J, Zhao H, Wang H, Bian J, Zheng R." A defensin antimicrobial peptide from the venoms of Nasonia vitripennis. DRAMP03046 ILGIITSLLKSL 12 "Orancis-protonectin (chain of Venom peptide 2-long; Venom peptide 2, OdVP2; Insects, animals)" "P86147, C7DT08" Belongs to the MCD family (Protonectin subfamily) VP2 Orancistrocerus drewseni (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None Function: Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations. Also exhibits strong antimicrobial activity against fungi. Venom peptide 2-long has substantially lower antimicrobial activity against C. albicans and bacteria than Orancis-protonectin but has equivalent activity against Botrytis cinerea. "[Ref.19857508]Gram-positive bacteria: Staphylococcus aureus (MIC=25 g/ml);##Fungi: Candida albicans (MIC<100 ?g/ml), Botrytis cinerea (MIC=0.5 ?g/ml)." [Ref.18695936]84% hemolytic activity at 50 M against sheep blood cells. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19857508##18695936 Toxicon. 2010 Apr 1;55(4):711-718.##Amino Acids. 2009 Jul;37(2):389-394. "Baek JH, Lee SH.##Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T." "Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).##Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni." DRAMP03047 EPILGIITSLLKSL 14 "Venom peptide 2-long (OdVP2L; analog of OdVP2; Insects, animals)" "P86147, C7DT08" Belongs to the MCD family (Protonectin subfamily) VP2 Orancistrocerus drewseni (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations. Tissue specificity: Expressed by the venom gland." "[Swiss_Prot Entry P86147]Fungi: Botrytis cinerea (MIC=0.5 ?g/ml), Candida albicans (MIC=100 ?g/ml);##Gram-positive bacterium: S. aureus (MIC=25 ?g/ml);##Gram-negative bacterium: Escherichia coli." [Swiss_Prot Entry P86147]has potent hemolytic activity against ovine erythrocytes at micromolar concentrations Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19857508##18695936 Toxicon. 2010 Apr 1;55(4):711-718.##Amino Acids. 2009 Jul;37(2):389-394. "Baek JH, Lee SH.##Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T." "Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).##Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni." DRAMP03050 INWKKIAEVGGKILSSL 17 "Dominulin-A (Insects, animals)" P0C1M6 Belongs to the MCD family (Mastoparan subfamily) Not found Polistes dominulus (European paper wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Shows antimicrobial activity. Gram-positive bacterium: Bacillus subtilis ATCC 6633 (MIC=2 ?g/ml);##Gram-negative bacterium: Escherichia coli JM109 (MIC=8 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16446098 J Am Soc Mass Spectrom. 2006 Mar;17(3):376-383. "Turillazzi S, Mastrobuoni G, Dani FR, Moneti G, Pieraccini G, la Marca G, Bartolucci G, Perito B, Lambardi D, Cavallini V, Dapporto L." "Dominulin A and B: two new antibacterial peptides identified on the cuticle and in the venom of the social paper wasp Polistes dominulus using MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap." DRAMP03051 INWKKIAEIGKQVLSAL 17 "Dominulin-B (Insects, animals)" P0C1M7 Belongs to the MCD family (Mastoparan subfamily) Not found Polistes dominulus (European paper wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Shows antimicrobial activity. Gram-positive bacterium: Bacillus subtilis ATCC 6633 (MIC=2 ?g/ml);##Gram-negative bacterium: Escherichia coli JM109 (MIC=8 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16446098 J Am Soc Mass Spectrom. 2006 Mar;17(3):376-383. "Turillazzi S, Mastrobuoni G, Dani FR, Moneti G, Pieraccini G, la Marca G, Bartolucci G, Perito B, Lambardi D, Cavallini V, Dapporto L." "Dominulin A and B: two new antibacterial peptides identified on the cuticle and in the venom of the social paper wasp Polistes dominulus using MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap." DRAMP03052 GAARKSIRLHRLYTWKATIYTR 22 "PP13 (Insects, animals)" No entry found Not found Not found Pteromalus puparum (wasp) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Alpha helix (CD) Not found None "Function: These peptides have net positive charges and are active against both Gram-negative and -positive bacteria, but are not active against fungi tested." "Gram-positive bacteria: Staphylococcus aureus CVCC1882 (MIC=23.3 ?M), Sarcina lutea CVCC1600 (MIC=8 ?M), Bacillus pumilus CVCC709 (MIC=9 ?M), Bacillus subtilis CVCC717 (MIC=13.3 ?M).##Gram-positive bacterium: Escherichia coli CVCC1570 (MIC=16.7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 19950104 J Pept Sci. 2010 Jan;16(1):58-64. "Shen X, Ye G, Cheng X, Yu C, Yao H, Hu C." Novel antimicrobial peptides identified from an endoparasitic wasp cDNA library. DRAMP03053 GSCSCSGTISPYGLRTCRATKTKPSHPTTKETHPQTLPT 39 "PP102 (Insects, animals)" No entry found Not found Not found Pteromalus puparum (wasp) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: These peptides have net positive charges and are active against both Gram-negative and -positive bacteria, but are not active against fungi tested." "Gram-positive bacteria: Staphylococcus aureus CVCC1882 (MIC=13.3 ?M), Sarcina lutea CVCC1600 (MIC=63.3 ?M), Bacillus pumilus CVCC709 (MIC=23.3 ?M), Bacillus subtilis CVCC717 (MIC=25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 19950104 J Pept Sci. 2010 Jan;16(1):58-64. "Shen X, Ye G, Cheng X, Yu C, Yao H, Hu C." Novel antimicrobial peptides identified from an endoparasitic wasp cDNA library. DRAMP03054 GKWGWIYITILFADVGGFKSSRHPEERRVQERRFKRITRGPD 42 "PP113 (Insects, animals)" No entry found Not found Not found Pteromalus puparum (wasp) "Antimicrobial, Antibacterial, Anti-Gram+" Not found Not found Not found None "Function: These peptides have net positive charges and are active against both Gram-negative and -positive bacteria, but are not active against fungi tested. Salt-dependency studies revealed that the biocidal activity of these peptides against E. coli decreased with increasing concentration of NaCl." "Gram-positive bacteria: Staphylococcus aureus CVCC1882 (MIC=13 ?M), Sarcina lutea CVCC1600 (MIC=16.7 ?M), Bacillus pumilus CVCC709 (MIC=23.3 ?M), Bacillus subtilis CVCC717 (MIC=23.3 ?M).##Gram-positive bacterium: Escherichia coli CVCC1570 (MIC=16.7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 19950104 J Pept Sci. 2010 Jan;16(1):58-64. "Shen X, Ye G, Cheng X, Yu C, Yao H, Hu C." Novel antimicrobial peptides identified from an endoparasitic wasp cDNA library. DRAMP03055 YVPPVQKPHPNGPKFPTFP 19 "PP30 (Pro-rich; abaecin-like; Insects, animals)" No entry found Not found Not found Pteromalus puparum (wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=23.32.1 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=16.72.1 ?M), Staphylococcus aureus (MIC=133.311.6 ?M), Sarcina lutea (MIC=13.31.2 ?M), Bacillus pumilu (MIC=13.32.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20466006 J Invertebr Pathol. 2010 Sep;105(1):24-29. "Shen X, Ye G, Cheng X, Yu C, Altosaar I, Hu C." Characterization of an abaecin-like antimicrobial peptide identified from a Pteromaluspuparum cDNA clone. DRAMP03056 SLLSLIRKLIT 11 "Decoralin (Insects, animals)" P85870 Not found Not found Oreumenes decoratus (Potter wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide. At high concentrations exhibits activity in stimulating degranulation from rat peritoneal mast cells. Inhibits the growth of L.major promastigotes in vitro with an IC50 of 72 ?M. Has hemolytic activity towards human and mouse erythrocytes. Tissue specificity: Expressed by the venom gland." "[Ref.17981364]Gram-positive bacteria: Staphylococcus aureus CCT 6538 (MIC=40 ?M), S. saprophyticus (MIC=40 ?M), Bacillus subtilis CCT 2471 (MIC=40 ?M), B. thuringiensis (MIC=40 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=80 ?M), Escherichia coli CCT 1371 (MIC=160 ?M), Klebsiella pneumoniae ATCC 13883 (MIC=80 ?M), A. faecalis ATCC 8750 (MIC=40 ?M);##Fungi: Candida albicans (MIC=40 ?M), L. major promastigotes (IC50=72 ?M)." [Ref.17981364]EC50=1 mM against mouse erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 17981364 Peptides. 2007 Dec;28(12):2320-2327. "Konno K, Rangel M, Oliveira JS, Dos Santos Cabrera MP, Fontana R, Hirata IY, Hide I, Nakata Y, Mori K, Kawano M, Fuchino H, Sekita S, Neto JR." "Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus." DRAMP18493 FIHHIIGGLISVGKHIHGLIHGH 23 TP3 L0CMD2 Piscidin TP3 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) "Antibacterial, wound healing, immunomodulatory, Anti-Gram+, Antimicrobial" Protein level Alpha helix Not found None Function: Antibacterial activity against the Gram-positive bacteria. Antifungal activity. Has hemolytic activity. "[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=256 g/ml; MBC=256 g/ml), Methicillin-resistant Staphylococcus aureus (MIC=256 g/ml; MBC>256 g/ml);##Fungi: Candida albicans (MIC=128 g/ml; MBC=128 g/ml)" "[Ref.29040295] 2% hemolysis at 3.13 g/ml, 5% hemolysis at 6.25 g/ml, 10% hemolysis at 12.50 g/ml, 55% hemolysis at 25.00 g/ml, 85% hemolysis at 50.00 g/ml, 100% hemolysis at 100.00 g/ml against mouse red blood cell" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 29040295 PLoS One. 2017 Oct 17;12(10):e0186442. "Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD." "Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4." DRAMP03069 DLHIPPPDNKINWPQLSGGGGGSPKTGYDININAQQK 37 "Diptericin (Insects, animals)" Q9TWW2 Belongs to the attacin/sarcotoxin-2 family Not found Sarcophaga peregrina (Flesh fly) "Antimicrobial, Antibacterial" Protein level Not found Not found None By injury to the body wall of the larva. Expression peaks at 10 hours post-injury and is maintained at this level for at least 3 days. "Escherichia coli (MIC=6.25 ?g/ml), Shigella sonnei (MIC=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1445217 Biochem J. 1992 Oct 15;287 (Pt 2):573-578. "Ishikawa M, Kubo T, Natori S." Purification and characterization of a diptericin homologue from Sarcophaga peregrina (flesh fly). DRAMP03075 WNPFKELERAGQRVRDAIISAGPAVATVAQATALAK 36 Cecropin-D P01511 Belongs to the cecropin family Not found Antheraea pernyi (Chinese oak silk moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. PTM: C-terminal amidation." "Gram-negative bacteria: Escherichia coli D21 (MIC=0.37 ?M), E. coli D31 (MIC=0.21 ?M), Serratia marsescens (MIC=6.1 ?M), S. marsescens Strain 122 (MIC=75 ?M), Pseudomonas aeruginosa OT97 (MIC>81 ?M), Xenorhabdus nematophilus Xn21 (MIC=16 ?M);##Gram-positive bacteria: Bacillus subtilis Bsll (MIC>81 ?M), Bacillus megaterium Bmll (MIC=24 ?M), Bacillus thuringiensis Btll (MIC>81 ?M), Streptococcus fecalis Ds16 (MIC>81 ?M), S. fecalis AD-4 (MIC>81 ?M), Micrococcus luteus MI11 (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 6754375 Eur J Biochem. 1982 Sep;127(1):219-224. "Qu Z, Steiner H, Engstr?m A, Bennich H, Boman HG." "Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi." DRAMP03089 GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATAR 39 "Drosophila cecropin-A1/A2 (Insects, animals)" "P14954, B3DN02, B3DN08, O16815, O16816, O16817, O16818, O16819, O16820" Belongs to the cecropin family CecA1 AND CecA2 Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None "Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. Tissue specificity: Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria. Maximal expression in the adult involves fat body cells of the head, thorax and abdomen. Induction: Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food. PTM: C-terminal amidation (By similarity)." "Gram-negative bacteria: Escherichia coli D21 (MIC=0.3 ?M), Enterobacter cloacae 12 (MIC=0.4 ?M), Pseudomonas aeruginosa OT97 (MIC=2.2 ?M), Serratia marcescens Db11 (MIC=93 ?M);##Gram-positive bacteria: Bacillus megatherium Bm11 (MIC=2.6 ?M), Bacillus subtilis Bsll (MIC=16 ?M), Micrococcus luteus MI11 (MIC=8.5 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2104802##2390977##9725836 EMBO J. 1990 Jan;9(1):217-224.##EMBO J. 1990 Sep;9(9):2969-2976. "Kylsten P, Samakovlis C, Hultmark D.##Samakovlis C, Kimbrell DA, Kylsten P, Engstr?m A, Hultmark D." The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.##The immune response in Drosophila: pattern of cecropin expression and biological activity. DRAMP03090 GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR 39 "Drosophila cecropin B (CecB; Insects, animals)" "P14956, O16826, O16827, O16828, O18647, O61274, Q9V425" Belongs to the cecropin family CecB Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food. [Ref.1]" "Gram-negative bacteria: Escherichia coli D21 (MIC=1.8 ?M), Enterobacter cloacae b12 (MIC=1.0 ?M), Pseudomonas aeruginosa OT97 (MIC=4.2 ?M);##Gram-positive bacteria: Bacillus megatherium Bm11 (MIC=3.7 ?M), Bacillus subtilis Bsll (MIC=3.2 ?M), Micrococcus luteus MI11 (MIC=59 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2390977##2104802 EMBO J. 1990 Sep;9(9):2969-2976.##EMBO J. 1990 Jan;9(1):217-224. "Samakovlis C, Kimbrell DA, Kylsten P, Engstr?m A, Hultmark D.##Kylsten P, Samakovlis C, Hultmark D." The immune response in Drosophila: pattern of cecropin expression and biological activity.##The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection. DRAMP03095 VFIDILDKVENAIHNAAQVGIGFAKPFEKLINPK 34 "Andropin (Insects, animals)" "P21663, A9UNE4, O16822, O16823, O16824, Q6LAI1, Q9VA90" Not found Anp Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Andropin is constitutively expressed in the adult male ejaculatory duct in response to mating not bacterial infection. Andropin is less fungicidal than the cecropins (Insect Biochem Mol Biol. 1999;29:965-72). Along with other antimicrobial proteins, this peptide sterilizes the reproduction system of insects and protects sperms from being infected by bacteria (J Insect Physiol. 2001 Jun;47(6):617-622). Similarly, ceratotoxins are expressed in the female reproductive accesary glands and expressed during mating." "Gram-negative bacteria: Escherichia coli D21 (MIC=140 ?M), Enterobacter cloacae b312 (MIC>300 ?M), Pseudomonas aeruginosa OT97 (MIC>300 ?M), Serratia marcescens Db 11 (MIC>127 ?M), Serratia marcescens Db 1140 (MIC>127 ?M);##Gram-positive bacteria: Bacillus megatherium Bml1 (MIC=11 ?M), Bacillus subtilis Bs11 (MIC=17 ?M), Micrococcus luteus MIll (MIC=20 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1899226 EMBO J. 1991; 10:163-169. "Samakovlis, C, Kylsten, P, Kimbrell, DA, Engstroem, A, Hultmark, D." "The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster." DRAMP03096 RRQGPIFDTRPSPFNPNQPRPGPIY 25 "Metchnikowin-2 (Insects, animals)" No entry found Not found Not found Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Micrococcus luteus (MIC=0.5-1.0 ?M).##Fungi: Neurospora crassa (MIC=0.5-1.0 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7588819 Eur J Biochem. 1995 Oct 15;233(2):694-700. "Levashina EA, Ohresser S, Bulet P, Reichhart JM, Hetru C, Hoffmann JA." "Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties." DRAMP18495 QCRRLCYKQRCVTYCRGR 18 "Gomesin (Gm; Spiders, arachnids, Chelicerata, arthropods, invertebrates, animals)" P82358 Belongs to the tachyplesin family Not found Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic, Antimalarial, Antic" Protein level Beta sheet Not found 1KFP resolved by NMR. "Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. It shows hemolytic activity. Tissue specificity: In hemocytes only, but not in all hemocytes observed." "[Ref.10942757] Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 M), Bacillus cereus (MIC=6.25-12.5 M), Bacillus megaterium (MIC=0.2-0.4 M), Bacillus thuringiensis (MIC=1.6-3.15 M), Enterococcus faecalis (MIC=6.2-12.5 M), Listeria monocytogenes (MIC=0.8-1.6 M), Micrococcus luteus (MIC=0.4-0.8 M), Pediococcus acidolacrici (MIC=3.15-6.25 M), Staphylococcus aureus (MIC=1.6-3.15 M), Staphylococcus epidermidis (MIC=0.8-1.6 M), Staphylococcus haemolyticus (MIC=0.8-1.6 M), Staphylococcus saprophyticus (MIC=0.8-1.6 M), Streptococcus pyogenes (MIC=1.6-3.15 M), Nocardia asteroides (MIC=1.6-3.15 M);##Gram-negative bacteria: Escherichia coli 1106 (MIC=0.8-1.6 M), Escherichia coli D22 (MIC=0.4-0.8 M), Escherichia coli D31 (MIC=0.8-1.6 M), Escherichia coli SBS363 (MIC=0.4-0.8 M), Erwinia carolovora (MIC=3.15-6.25 M), Enterobacter cloacae 12 (MIC=3.15-6.25 M), Klebsiella pneumoniae (MIC=3.15-6.25 M), Pseudomonas aeruginosa (MIC=1.6-3.15 M), Salmonella thyphinurium (MIC=0.8-1.6 M), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 M);##Fungi: Alternaria brassicola (MIC=0.4-0.8 M), Aspergillus fumigatus (MIC=1.6-3.15 M), Beauveria bassiana (MIC=12.5-25 M), Fusarium culmorum (MIC=0.4-0.8 M), Fusarium oxysporum (MIC=0.4-0.8 M), Neurospora crassa (MIC=0.4-0.8 M), Nectria haematococca (MIC=0.2-0.4 M), Tricoderma viridae (MIC=0.4-0.8 M), Tricophvton mentagrophytes (MIC=0.8-1.6 M);##Yeasts: Candida albicans (MIC=0.15-0.3 M), Candida glabrata (MIC=12.5-25 M), Candida tropicalis (MIC=3.15-6.25 M), Cryptococcus neoformans (MIC=0.8-1.6 M), Saccharomyces cerevisiae (MIC=1.6-3.15 M)." [Ref.10942757] It exhibits 16% hemolysis at 1 M and 100 M against human erythrocytes Cyclic pyroglutamic acid Amidation "Disulfide bond between Cys2 and Cys15,Cys6 and Cys11." L No cytotoxicity information found Not found 10942757 J Biol Chem. 2000 Oct 27;275(43):33464-70. "Silva PI Jr, Daffre S, Bulet P." "Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family." DRAMP03098 HRHQGPIFDTRPSPFNPNQPRPGPIY 26 "Metchnikowin (Pro-rich; Insects, animals)" "Q24395, Q24396, Q86BV8, Q9V7B9" Not found Mtk Drosophila melanogaster (Common fruit fly) "Antimicrobial, Antibacterial, Antifungal" Protein level Rich in Proline Not found None Transgenic plants: Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens (J Exp Bot. 2009;60(14):4105-14). "Micrococcus luteus (MIC=0.5-1.0 ?g/ml), Neurospora crassa (MIC=0.5-1.0 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7588819 Eur J Biochem. 1995 Oct 15;233(2):694-700. "Levashina E.A, Ohresser S, Bulet P, Reichhart JM, Hetru C, Hoffmann J.A." "Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties." DRAMP03104 ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN 40 "Sapecin (defensins; Insects, animals)" P18313 Belongs to the invertebrate defensin family (Type 1 subfamily) Not found Sarcophaga peregrina (Flesh fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Combine helix and strand structure Not found 1L4V resolved by NMR. "Function: Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria. Tissue specificity: Hemocytes and fat body. Induction: By injury to the larval cell wall. PTM: Contains three disulfide bonds 3-30; 16-36; 20-38." "Gram-positive bacteria: Staphylococcus aureus FDA209P (MIC=5.0 ?g/ml), Staphylococcus smith (MIC=5.0 ?g/ml), Micrococcus luteus FDA16 (MIC=1.2 ?g/ml), Micrococcus luteus IF03333 (MIC=1.2 ?g/ml), Micrococcus luteus PC11001 (MIC=10.0 ?g/ml), Bacillus subtilis NRRI B-558 (MIC=39.0 ?g/ml), Bacillus subtilis PC1219 (MIC=20.0 ?g/ml), Mycobacterium smegmatis ATCC607 (MIC=78.0 ?g/ml), Corynebacterium bouis 1810 (MIC=2.5 ?g/ml), Corynebacterium michiganense (MIC=2.5 ?g/ml).##Gram-negative bacteria: Xantbmonas oryzae (MIC=20.0 ?g/ml), Pseudomonas lachrymans (MIC=78.0 ?g/ml), Escherichia coli NIHJ (MIC>78.0 ?g/ml), Shigella sonnei JS11746 (MIC>78.0 ?g/ml), Proteus vulgaris O X19 (MIC>78.0 ?g/ml) " No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys3 and Cys30; Cys16 and Cys36; Cys20 and Cys38. L No cytotoxicity information found Not found 3182836##3182836##2358424 J Biol Chem. 1988 Nov 15;263(32):17117-17121.##J Biol Chem. 1988 Nov 15;263(32):17112-17116.##J Biochem. 1990 Apr;107(4):514-518. "Matsuyama K, Natori S.##Matsuyama K, Natori S.##Kuzuhara T, Nakajima Y, Matsuyama K, Natori S." "Molecular cloning of cDNA for sapecin and unique expression of the sapecin gene during the development of Sarcophaga peregrina.##Purification of three antibacterial proteins from the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina.##Determination of the disulfide array in sapecin, an antibacterial peptide of Sarcophaga peregrina (flesh fly)." DRAMP03113 SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK 84 "SK84 (Gly-rich; Insects, animals)" No entry found Not found Not found Drosophila virilis (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiviral" Not found Not found Not found None "Function: SK84 displays antibacterial activity against the tested Gram-positive bacteria (B. subtilis, Bacillus thuringiensis and Staphylococcus aureus), but had no effect on Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and fungi (Saccharomyces cerevisiae, Candida albicans). Has weak hemolytic activity." "[Ref.19799950]Gram-positive bacteria: Bacillus thuringiensis ATCC 1041 (MIC=4 ?M), B. subtilis ATCC 9372 (MIC=8 ?M), Staphylococcus aureus ATCC 6538 (MIC=8 ?M)." [Ref.19799950]0.01% hemolytic activity at 100 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19799950 Peptides. 2010 Jan;31(1):44-50. "Lu J, Chen ZW." "Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis." DRAMP03116 SLGGVISGAKKVAKVAIPIGKAVLPVVAKLVG 32 "Ceratotoxin-C (Insects, animals)" Q17313 Not found CTXC1 AND CTCX2 Ceratitis capitata (Mediterranean Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Has hemolytic activity.Temperature dependence: Thermostable. Still active at 100 degrees Celsius. "[Ref.9569644]Gram-negative bacteria: Escherichia coli 23739 (MIC=13.6 ?M), Escherichia coli LE 392 (MIC=5 ?M), Pseudomonas aeruginosa 27853 (MIC>50 ?M), P. vulgaris 6380 (MIC>50 ?M), S. typhymurium 23853 (MIC>5 ?M);##Gram-positive bacteria: E. cloacae 13047 (MIC>5 ?M), E. jaecalis 29212 (MIC>50 ?M), Staphylococcus aureus 25923 (MIC>50 ?M), B. cereus 9634 (MIC>5 ?M), Bacillus subtilis 6633 (MIC=5.9 ?M)." [Swiss_Prot Entry Q17313]has hemolytic activity Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9569644 Eur. J. Biochem. 1996; 241:330-337. "Rosetto M, Manetti AGO, Giordano PC, Marri L, Amons R, Baldari CT, Marchini D, Dallai R." "Molecular characterization of ceratotoxin C, a novel antibacterial female-specific peptide of the ceratotoxin family from the medfly Ceratitis capitata." DRAMP03117 QSEAGWLKKIGKKIERVGQHTRDATIQGLGVAQQAPNVAATAR 43 "Drosophila cecropin-A1 (Insects, animals)" O61272 Belongs to the cecropin family CecA1 Drosophila simulans (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Homology Not found Not found None "Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. PTM: C-terminal amidation (By similarity)." "Gram-negative bacteria: Alcaligenes faecalis (MIC=10-25 ?M), Escherichia coli 1106 (MIC=0.25-0.5 ?M), Escherichia coli D22 (MIC=0.1-0.25 ?M), Escherichia coli D31 (MIC=0.1-0.25 ?M), Escherichia coli SBS363 (MIC=0.1-0.25 ?M), Enterobacter cloacae 12 (MIC=0.5-1 ?M), Erwinia carotovora (MIC=0.5-1 ?M), Klebsiella pneumoniae (MIC=1-2.5 ?M), Pseudomonas aeruginosa (MIC=1-2.5 ?M), Salmonella typhimurium (MIC=0.5-1 ?M), Xanthomonas campestris (MIC=0.5-1 ?M); ##Gram-positive bacteria: Aerococcus viridans (MIC=5-10 ?M), Bacillus megaterium (MIC=1-2.5 ?M), Micrococcus luteus (MIC=5-10 ?M).##Fungi: Botrytis cinerea (MIC=5-10 ?M), Fusarium culmorum (MIC=1-2.5 ?M), Fusarium oxysporum (MIC=1-2.5 ?M), Neurospora crassa (MIC=2.5-10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9553148##9725836 Immunogenetics. 1998 May;47(6):417-429.##Genetics. 1998 Sep;150(1):157-171.##Insect Mol Biol. 2000 Feb;9(1):75-84. "Date A, Satta Y, Takahata N, Chigusa S.I.##Ramos-Onsins S, Aguade M.##Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, Mller HM, Dimopoulos G, Hoffmann J, Kafatos FC, Richman A." "Evolutionary history and mechanism of the Drosophila cecropin gene family.##Molecular evolution of the Cecropin multigene family in Drosophila: functional genes vs pseudogenes.##Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae." DRAMP03137 ATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCRN 40 "Defensin-A (AaeDefA; Insects, animals)" "P91793, O77250, P91794, P91795, P91796, Q17EE3, Q6ITZ2, Q963E9" Belongs to the invertebrate defensin family (Type 1 subfamily) DEFA Aedes aegypti (Yellowfever mosquito) "Antimicrobial, Antibacterial, Anti-Gram+" Protein level Bridge Not found None Function: Antibacterial peptide mostly active against Gram-positive bacteria. Has activity against the bacteria Gram-negative E. cloacae beta12. "Gram-positive bacteria: Enterobacter cloacae beta12 (MIC=1.2-2.4 ?M), Aerococcus viridans (MIC=0.6-1.2 ?M), Micrococcus luteus (MIC=0.6-1.2 ?M), Bacillus rnegaterium (MIC=0.6-1.2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Has three disulfide bonds L No cytotoxicity information found Not found 7633471##7568275 Insect Biochem Mol Biol. 1995 Jul;25(7):867-873.##Proc Biol Sci. 1995 Aug 22;261(1361):217-221. "Lowenberger C, Bulet P, Charlet M, Hetru C, Hodgeman B, Christensen BM, Hoffmann JA.##Chalk R, Albuquerque CM, Ham PJ, Townson H." "Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti.##Full sequence and characterization of two insect defensins: immune peptides from the mosquito Aedes aegypti." DRAMP03138 GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL 34 "Cecropin-A (Insects, animals)" "P82592, Q17NR3, Q95PI9" Belongs to the cecropin family CECA Aedes aegypti (Yellowfever mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli D22 (MIC=0.25-0.5 ?g/ml), E. coli D31 (MIC=0.25-0.5 ?g/ml), E. coli SBS363 (MIC=0.1-0.25 ?g/ml), E. coli 1106 (MIC=0.25-0.5 ?g/ml), Enterobacter cloacae b12 (MIC=50-100 ?g/ml), E. carotovora (MIC=0.25-0.5 ?g/ml), Klebsiella pneumoniae (MIC=1-2.5 ?g/ml), Pseudomonas aeruginosa (MIC=10-25 ?g/ml), Salmonella typhimurium (MIC=1-2.5 ?g/ml), X. campestris (MIC=0.5-1 ?g/ml);##Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 ?g/ml), Bacillus megaterium (MIC=1-2.5 ?g/ml), Micrococcus luteus (MIC=10-25 ?g/ml), Streptococcus pyogenes (MIC=10-25 ?g/ml).##Fungi: Fusarium culmorum (MIC=1-2.5 ?g/ml), Fusarium oxysporum (MIC=2.5-5 ?g/ml), Neurospora crassa (MIC=5-10 ?g/ml), Candida albicans (MIC=25-50 ?g/ml), Cryptococcus neoformans (MIC=25-50 ?g/ml), Saccharomyces cerevisiae (MIC=50-100 ?g/ml) " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10400619 J Biol Chem. 1999 Jul 16;274(29):20092-20097. "Lowenberger C, Charlet M, Vizioli J, Kamal S, Richman A, Christensen BM, Bulet P." "Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti." DRAMP03140 GRLKKLGKKIEGAGKRVFKAAEKALPVVAGVKALG 35 "Anopheles cecropin-A amidated isoform (Insects, animals)" "P82290, A7XAX5, A7XAX7, A7XAY1, A7XAY8, A7XAZ7, A7XB12, A7XB23, Q7QEE3" Belongs to the cecropin family CecA Anopheles gambiae (African malaria mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antibacterial activity against several Gram-positive and Gram-negative bacteria. Also has antifungal activity. Tissue specificity: Relatively abundant in head, thorax and to a lesser extent in abdominal carcass and anterior midgut. Developmental stage: In young pupae, expressed within 2 hours of infection and continued to accumulate over 16 hours. Induction: By bacterial infection. PTM: C-terminal amidation." "Gram-negative bacteria: Alcaligenes faecalis (MIC=1-2.5 ?M), Escherichia coli 1106 (MIC=0.5-1 ?M), E. coli D22 (MIC=0.1-0.25 ?M), E. coli D31 (MIC=0.1-0.25 ?M), E. coli SBS363 (MIC=0.05-0.1 ?M), Enterobacter cloacae 12 (MIC=0.5-1 ?M), Erwinia carotovora (MIC=0.5-1 ?M), Klebsiella pneumoniae (MIC=1-2.5 ?M), Pseudomonas aeruginosa (MIC=1-2.5 ?M), Salmonella typhimurium (MIC=0.1-0.25 ?M), Xanthomonas campestris (MIC=0.5-1 ?M); ##Gram-positive bacteria: Aerococcus viridans (MIC=0.5-1 ?M), Bacillus cereus (MIC=50-100 ?M), Bacillus megaterium (MIC=0.5-1 ?M), Listeria monocytogenes (MIC=50-100 ?M), Micrococcus luteus (MIC=0.5-1 ?M), Staphylococcus aureus (MIC=50-100 ?M), Staphylococcus epidermidis (MIC=10-25 ?M), Staphylococcus haemolyticus (MIC=1-2.5 ?M), Staphylococcus saprophyticus (MIC=1-2.5 ?M), Streptococcus pyogenes (MIC=0.1-0.25 ?M).##Fungi: Aspergillus fumigatus (MIC=5-10 ?M), Botrytis cinerea (MIC=1-2.5 ?M), Fusarium culmorum (MIC=0.5-1 ?M), Fusarium oxysporum (MIC=1-2.5 ?M), Neurospora crassa (MIC=1-2.5 ?M), Candida albicans (MIC=1-2.5 ?M), Cryptococcus neoformans (MIC=5-10 ?M), Saccharomyces cerevisiae (MIC=25-50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10672074##12421409 Insect Mol Biol. 2000 Feb;9(1):75-84.##Insect Mol Biol. 2002 Dec;11(6):517-525. "Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, Mller HM, Dimopoulos G, Hoffmann J, Kafatos FC, Richman A.##Zheng XL, Zheng AL." "Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae.##Genomic organization and regulation of three cecropin genes in Anopheles gambiae." DRAMP03150 MVFAYAPTCARCKSIGARYCGYGYLNRKGVSCDGQTTINSCEDCKRKFGRCSDGFITECFL 61 "Gambicin (Insects, animals)" No entry found Not found Not found Anopheles albimanus (mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic" Not found Bridge Not found None "Function: In vitro experiments showed that the 6.8-kDa mature peptide can kill both Gram-positive and Gram-negative bacteria, has a morphogenic effect on a filamentous fungus, and is marginally lethal to Plasmodium berghei ookinetes. Induction: Predominantly expressed in the anterior part. PTM: Contains four disulfide bridges." Gram-negative bacterium: E. coli (MIC=6.25-12.5 ?M);##Gram-positive bacterium: M. luteus (MIC=25-50 ?M).##Fungus: N. crassa. No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys9 and Cys20; Cys12 and Cys32; Cys41 and Cys51,Cys44 and Cys59." L No cytotoxicity information found Not found 11606751 Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12630-5. "Vizioli J, Bulet P, Hoffmann JA, Kafatos FC, Mller HM, Dimopoulos G." Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae. DRAMP03153 GIGGKPVQTAFVDNDGIYD 19 27 kDa antibacterial protein P81925 Not found Not found Cyprinus carpio (common carp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None Function: Has antibacterial activity. Forms large ion channels responsible for disrupting the cellular envelope of bacteria leading to cell lysis. "Gram-positive bacteria: Staphylococcus aureus (MIC=5 ?g/ml), Micrococcus luteus (MIC=0. 5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=5 ?g/ml), Pseudomonas fluorescens (MIC=10 ?g/ml), Aeromonas hydrophila (MIC=5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 8797847 Eur J Biochem. 1996 Aug 15;240(1):143-149. "Lema??tre C, Orange N, Saglio P, Saint N, Gagnon J, Molle G." Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio). DRAMP03162 ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR 40 "Phlebotomus duboscqi defensin (PduDef; defensins; Insects, animals)" P83404 Belongs to the invertebrate defensin family (Type 1 subfamily) Not found Phlebotomus duboscqi "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiparasitic" Protein level Bridge Not found None "Function: Has antiparasitic and antifungal activity. Tissue specificity: Is synthesized by the fat body and eventually secreted into the hemolymph. Induction: By bacterial and parasitic hemolymph and gut infections. Expression peaks at 24 hours post infection by bacterium P. carotovorum, and at day four post infection by the parasite L. major. PTM: Problely contains three disulfide bonds 3-30; 16-36; 20-36." "Gram-positive bacteria: Staphylococcus aureus (MIC=0.78-1.56 ?M), Aspergillus fumigatus (MIC=12.5-25 ?M).##Fungi: Fusarium culmorum (MIC=1.56-3.12 ?M), Fusarium oxysporum (MIC=3.12-6.25 ?M), Neurospora crassa (MIC=6.25-12.5 ?M), Trichoderma viride (MIC=3.12-6.25 ?M), Trichophyton mentagrophytes (MIC=25-50 ?M), Candida albicans (MIC=6.25-12.5 ?M), Saccharomyces cerevisiae (MIC=25-50 ?M).##Parasite: Leishmania major promastigote forms (IC50=68-85 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys3 and Cys30; Cys16 and Cys36; Cys20 and Cys36. L No cytotoxicity information found Not found 15557638 Infect Immun. 2004 Dec;72(12):7140-7146. "Boulanger N, Lowenberger C, Volf P, Ursic R, Sigutova L, Sabatier L, Svobodova M, Beverley SM, Sp?th G, Brun R, Pesson B, Bulet P." Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major. DRAMP03166 IRNSLTCRFNFGICLPKRCPGRMRQIGTCF 30 "P15 (deer beta-defensin; ruminant, animals)" No entry found Not found Not found Cervus elaphus (New Zealand deer) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: It shows strong activity against Gram-negative bacteria, but lesser activity against Gram-positive bacteria and yeast. Caution: the sequence displayed is N-terminal sequence of P15. " Gram-negative bacterium: Escherichia coli O111 (MIC=0.3 ?g/mL);##Gram-positive bacterium: Staphylococcus aureus NCTC 4163 (MIC=1 ?g/mL).##Fungi: Candida albicans 3135A (MIC=3 ?g/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16011891 Int J Antimicrob Agents. 2005 Aug;26(2):165-169. "Treffers C, Chen L, Anderson RC, Yu PL." Isolation and characterisation of antimicrobial peptides from deer neutrophils. DRAMP03169 RARAPHKAWYNCMTDAGISGAIAGAVAGCAATIEIGCVEGAIAGIGPSGIASMIAALWTCRSKY 64 Protease-activated antimicrobial peptide No entry found Not found Not found Propionibacterium jensenii "Antimicrobial, Antibacterial" Not found Not found Not found None Comment: No comments found on DRAMP database "Propionibacterium acidipropionici ATCC 4965 (MIC=3.6 nM), P. acidipropionici ATCC 4875 (MIC=7.2 nM), P. acidipropionici (MIC=3.6 nM), P. freudenreichii subsp. freudenreichii ATCC 6207T (MIC=7.2 nM), P. freudenreichii INF-P203 (MIC=116 nM), P. freudenreichii INF-P205 (MIC=58 nM), P. jensenii LMG 2820 (MIC=116 nM), P. jensenii LMG 3032 (MIC=116 nM), P. thoenii INF-P410 (MIC=116 nM), P. thoenii INF-P414 (MIC=0.9 nM), Lactobacillus delbrueckii subsp. lactis ATCC 4797 (MIC=0.5 nM), L. delbrueckii subsp. lactis DSM 20072T (MIC=0.2 nM), L. delbrueckii subsp. bulgaricus DSM 20081T (MIC=7.2 nM), L. helveticus DSM 20075T (MIC=0.9 nM), Lactobacillus plantarum LMG 2003 (MIC=116 nM), L. sakei NCDO 2714 (MIC=0.9 nM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12057960 J Bacteriol. 2002 Jul;184(13):3649-3656. "Faye T, Brede DA, Langsrud T, Nes IF, Holo H." An antimicrobial peptide is produced by extracellular processing of a protein from Propionibacterium jensenii. DRAMP03173 RWCVYAYVRVRGVLVRYRRCW 21 "Arenicin-1 (Ar-1; marine polychaeta, animals)" "Q5SC60, P84105" Not found Not found Arenicola marina (Lugworm) (Lumbricus marinus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Cytotoxic" Protein level Beta strand (2 strands; 16 residues) "Arenicin-1 is a two-stranded antiparallel -sheet (Cys3-Val10 and Val13-Cys20) stabilized by nine intra-backbone hydrogen bonds and a disulfide bond between Cys3 and Cys20. The strands of the -sheet are connected by a type I? -turn. The surface of arenicin is amphiphilic, with distinct hydrophobic and hydrophilic areas (ref.2)." 2JSB resolved by NMR. "Function: Has antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteriua as well as yeast C. albicans. Bacterial killing occurs within minutes and is accompanied by membrane permeabilization, membrane detachment and release of cytoplasm. Interaction of arenicin with reconstituted membranes that mimic the lipopolysaccharide-containing outer membrane or the phospholipid-containing plasma membrane of Gram-negative bacteria exhibited no pronounced lipid specificity. PTM: Contains one disulfide bond 3-20. Domian: Contains 1 BRICHOS domain." "Gram-positive bacterium: Listeria monocytogenes EGD (MIC=0.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35p (MIC=4 ?g/ml), E. coli WBB01 (MIC=0.3 mM), E. coli ATCC 23716 (MIC=0.6 mM), Salmonella enterica R595 (MIC=0.3 mM), S. enterica R60 (MIC=1.25 mM), Proteus mirabilis R45 (MIC=0.6 mM).##Yeast: Candida albicans 820 (MIC=20 ?g/ml).##Human Jurkat T-cells: LD50>40 mM (35.5% lysis at 30 mM)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys3 and Cys20. L "[Ref.27940358] Cytotoxicity: human embryonic fibroblasts (HEF) and human red blood cells (hRBC)(IC50 for arenicin-1 in the presence or absence of 10% FBS were of 35 and 8 M,HC50 indicating 50% hemolysis after 24 h incubation, equaled to 16M)." Anionic lipid vesicles 15527787##17935487 FEBS Lett. 2004 Nov 5;577(1-2):209-214.##Biochem J. 2008 Feb 15;410(1):113-122. "Ovchinnikova TV, Aleshina GM, Balandin SV, Krasnosdembskaya AD, Markelov ML, Frolova EI, Leonova YF, Tagaev AA, Krasnodembsky EG, Kokryakov VN.##Andr? J, Jakovkin I, Gr?tzinger J, Hecht O, Krasnosdembskaya AD, Goldmann T, Gutsmann T, Leippe M." "Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina.##Structure and mode of action of the antimicrobial peptide arenicin." DRAMP03176 SWLSKTAKKLENSAKKRISEGIAIAIQGGPR 31 "Cecropin-P1 (CP1; nematodes, animals)" "P14661, Q5H7N7" Belongs to the cecropin family ASCEC-1 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) "Antimicrobial, Antibacterial, Antifungal" Protein level Alpha helix Not found None "Function: Has antibacterial activity against several Gram-positive and Gram-negative bacteria. Is weakly active against yeasts. Acts by a nonpore mechanism. Induction: By bacterial infection." "P1-NH2 (amidated cecropin P1): [E. coli K-12/ D21 (MIC=0.3 ?M), E. coli 853/67/0149/K88 (MIC=0.9 ?M), E. coli Bd2221/75/08/K88 (MIC=0.6 ?M), E. coli Bd4462/84/0101/K99 (MIC=0.7 ?M), E. coli Bd4466/84/064/K99 (MIC=0.3 ?M), Salmonella typhimurium LT2 (MIC=0.9 ?M), A. calcoaceticus Ac1l (MIC=0.2 ?M), Proteus vulgaris Pvll (MIC=5.7 ?M), Pseudomonas aeruginosa OT97 (MIC=5.9 ?M), Bacillus megaterium Bmll (MIC=1.8 ?M), Streptococcus pyogenes (MIC=19 ?M)].##P1-OH (non-amidated cecropin P1): [E. coli K-12/ D21 (MIC=0.4 ?M), E. coli 853/67/0149/K88 (MIC=0.6 ?M), E. coli Bd2221/75/08/K88 (MIC=0.7 ?M), E. coli Bd4462/84/0101/K99 (MIC=0.8 ?M), E. coli Bd4466/84/064/K99 (MIC=0.6 ?M), Salmonella typhimurium LT2 (MIC=1.7 ?M), A. calcoaceticus Ac1l (MIC=0.5 ?M), Proteus vulgaris Pvll (MIC=12 ?M), Pseudomonas aeruginosa OT97 (MIC=13 ?M), Bacillus megaterium Bmll (MIC=5.3 ?M), Streptococcus pyogenes (MIC=44 ?M)]." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15850460##1396696 Biochem J. 2005 Aug 15;390(Pt 1):207-214.##Eur J Biochem. 1992 Oct 1;209(1):163-169. "llai A, Ueno S, Zhang H, Lee JM, Kato Y.##Sipos D, Andersson M, Ehrenberg A." "Cecropin P1 and novel nematode cecropins: a bacteria-inducible antimicrobial peptide family in the nematode Ascaris suum.##The structure of the mammalian antibacterial peptide cecropin P1 in solution, determined by proton-NMR." DRAMP03181 HVDKKVADKVLLLKQLRIMRLLTRL 25 "Spinigerin (Insects, animals)" P82357 Not found Not found Pseudacanthotermes spiniger (Termite) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "1ZRW, 1ZRV resolved by NMR." Function: Active against Gram-positive bacteria and Gram-negative bacteria and fungi. "Gram-positive bacteria: Bacillus megaterium (MIC=0.8-1.5 ?M), Micrococcus luteus (MIC=0.8-1.5 ?M);##Gram-negative bacteria: Escherichia coli SBS363 (MIC=3-6 ?M), E. coli D22 (MIC=3-6 ?M), Klebsiella pneumoniae (MIC=50-100 ?M), Salmonella typhimurium (MIC=3-6 ?M), Pseudomonas aeruginosa (MIC=50-100 ?M).##Fungi: Trichoderma viride (MIC=1.5-3 ?M), Neurospora crassa (MIC=3-6 ?M), Fusarium culmorum (MIC=1.5-3 ?M), Nectria haematococca (MIC=0.4-0.8 ?M), Candida albicans (MIC=3-6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11053427##16170803 J Biol Chem. 2001 Feb 9;276(6):4085-4092.##Biopolymers. 2006 Feb 5;81(2):92-103. "Lamberty M, Zachary D, Lanot R, Bordereau C, Robert A, Hoffmann JA, Bulet P.##Landon C, Meudal H, Boulanger N, Bulet P, Vovelle F." "Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect.##Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation." DRAMP03186 SFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW 38 "Spheniscin-2 (Sphe-2; penguin avian beta-defensin 103b; birds ,animals)" P83430 Belongs to the beta-defensin family Not found Aptenodytes patagonicus (King penguin) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand (3 strands; 14 residues) "The overall fold of Sphe-2 includes a three-stranded antiparallel beta-sheet stabilized by three disulfide bridges with a pairing typical of beta-defensins. In addition, the N-terminal segment shows helical features on most structures.(Ref.2)" 1UT3 resolved by NMR. "Function: Has antimicrobial activity. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane Function: with its amphipathic structure. PTM: Contains three disulfide bond: 5-33; 12-27; 17-34. Preserving food in the bird somach for several weeks during egg incubation. The disulfide bond pattern is identical to canonical beta-defensins from mammals. The high potency is related to its high cationicity as well as a hydrophobic patch, which is not observed in mammalian defensins. " "[Ref.14525994]Gram-positive bacteria: Micrococcus luteus (MIC=1.5-3.0 ?M), Bacillus subtilis (MIC=0.8-1.5 ?M), Bacillus cereus ATCC 11778 (MIC=3-6 ?M), Bacillus megaterium (MIC=0.4-0.8 ?M), Staphylococcus aureus (MIC=1.5-3.0 ?M), Staphylococcus saprophyticus (MIC=1.5-3.0 ?M), Staphylococcus haemolyticus (MIC=1.5-3.0 ?M), Nocardia asteroides (MIC=0.8-1.5 ?M), Aerococcus viridans (MIC=0.4-0.8 ?M), Listeria monocytogenes (MIC=6-12 ?M);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=0.8-1.5 ?M), Escherichia coli 1106 (MIC=1.5-3.0 ?M), Salmonella typhimurium (MIC=6-12 ?M), Klebsiella pneumoniae (MIC=50-100 ?M), Pseudomonas aeruginosa ATCC 82118 (MIC=6-12 ?M), Vibrio metschnikovii NCTC 8483 (MIC=25-50 ?M), Vibrio anguillarum ATCC 19264 (MIC=25-50 ?M);##Fungi: Candida glabrata (MIC>100 ?M), Candida albicans IHEM 8060 (MIC=50-100 ?M), Candida tropicalis (MIC=1.5-3.0 ?M), Neurospora crassa (MIC=3-6 ?M),Aspergillus fumigatus (MIC=3-6 ?M)." It has hemolytic activity Cyclic Free Free Disulfide bonds between Cys5 and Cys33; Cys12 and Cys27; Cys17 and Cys34. L No cytotoxicity information found Not found 14525994##15123713 J Biol Chem. 2003 Dec 19;278(51):51053-51058.##J Biol Chem. 2004 Jul 16;279(29):30433-30439. "Thouzeau C, Le Maho Y, Froget G, Sabatier L, Le Bohec C, Hoffmann JA, Bulet P.##Landon C, Thouzeau C, Labb H, Bulet P, Vovelle F." "Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus.##Solution structure of spheniscin, a beta-defensin from the penguin stomach." DRAMP03187 QRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCR 36 "Beta defensin 1(BD-1; mammals, animals)" P83943 Belongs to the beta-defensin family DEFB1 Chinchilla lanigera (Long-tailed chinchilla) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial and antifungal activity. May have a role in maintaining sterility in the middle ear. Gram-negative bacterium: Moraxella catarrhalis (MIC=5 ?g/ml);##Gram-positive bacterium: Streptococcus pneumoniae (MIC=5 ?g/ml).##Fungi: Candida albicans (MIC=12.5-20 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14996845 J Biol Chem. 2004 May 7;279(19):20250-20256. "Harris RH, Wilk D, Bevins CL, Munson RS Jr, Bakaletz LO." Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway. DRAMP03190 RLGNFFRKAKKKIGRGLKKIGQKIKDFLGNLVPRTES 37 "PobRL-37 (cathelicidin; primates, mammals, animals)" No entry found Not found Not found Cercopithecidae "Antimicrobial, Antibacterial, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "In 20% TSB in SPB medium: Escherichia coli (MIC=0.5 ?M), Pseudomonas aeruginosa (MIC=0.5-1 ?M), Staphylococcus aureus (MIC=2 ?M), Enterococcus faecalis (MIC=2-4 ?M).##In 20% SAB in SPB: Candida albicans (MIC=8-16 ?M). In 5% TSB in SPB: Escherichia coli (MIC=0.5 ?M). In 5% SAB in SPB: Candida albicans (MIC=4-8 ?M).##In 20% TSB in PIL: Escherichia coli (MIC=1 ?M), Pseudomonas aeruginosa (MIC=1-2 ?M); Staphylococcus aureus (MIC=0.5 ?M), Enterococcus faecalis (MIC=1-2 ?M).##In 20% SAB in PIL: Candida albicans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16720578 J Biol Chem. 2006 Jul 21;281(29):19861-19871. "Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A." Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity. DRAMP03196 RCVCRRGVCRCVCTRGFC 18 "PhTD-1 (PhTD1; primates, mammals, animals)" "P86722, P86723" Not found Not found Papio hamadryas (Hamadryas baboon) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "In low salt conditions: Escherichia coli ML35p (MIC=1.5 ?M), Listeria monocytogenes EGD (MIC=1.6 ?M) and methicillin-resistant Staphylococcus aureus ATCC 33591 (MIC=2.5 ?M),.##Fungi: Candida albicans 820 (MIC=1.6 ?M);##At high physiological salt concentrations: Escherichia coli ML35p (MIC=2.0 ?M), Listeria monocytogenes EGD (MIC=1.7 ?M), Staphylococcus aureus ATCC 33591 (MIC=3.6 ?M), Candida albicans 820 (MIC=6.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys2 and Cys11; Cys4 and Cys9; Cys13 and Cys18. L No cytotoxicity information found Not found 20155756 Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604. "Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R." De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. DRAMP03197 RCVCTRGFCRCVCTRGFC 18 "PhTD-3 (PhTD3; primates, mammals, animals)" "P86722, P86723" Not found Not found Papio hamadryas (Hamadryas baboon) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "In low salt conditions: Escherichia coli ML35p (MIC=1.7 ?M), Listeria monocytogenes EGD (MIC=1.5 ?M), Staphylococcus aureus ATCC 33591 (MIC=1.7 ?M), Candida albicans 820 (MIC=1.4 ?M);##At high physiological salt concentrations: Escherichia coli ML35p (MIC=2.2 ?M), Listeria monocytogenes EGD (MIC=1.9 ?M), Staphylococcus aureus ATCC 33591 (MIC=4.5 ?M), Candida albicans 820 (MIC=7.4 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys2 and Cys11; Cys4 and Cys9; Cys13 and Cys18. L No cytotoxicity information found Not found 20155756 Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604. "Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R." De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. DRAMP03198 ACYCRIPACFAGERRYGTCFYLGRVWAFCC 30 "Alpha-defensin PhD-4 (primates, mammals, animals)" P86724 Belongs to the alpha-defensin family Not found Papio hamadryas (Hamadryas baboon) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity in low salt conditions, and the antimicrobial activity decreases significantly at high physiological salt concentrations. PTM: Contains three disulfide bonds (By similarity)." "In low salt conditions: Gram-negative bacterium: E. coli ML35p (MIC=2.4 ?M),;##Gram-positive bacteria: Listeria monocytogenes EGD (MIC=2.2 ?M), methicillin-resistant S. aureus ATCC 33591 (MIC=3.5 ?M).##Fungi: Candida albicans 820 (MIC=3.9 ?M).##At high physiological salt concentrations: E. coli ML35p (MIC=7.1 ?M), L. monocytogenes EGD (MIC=1.8 ?M), S. aureus ATCC 33591 (MIC>50 ?M), Candida albicans 820 (MIC>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20155756 Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604. "Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R." De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. DRAMP03215 ZCRRLCYKQRCVTYCRGR 18 "Gomesin (Gm; spiders, Arthropods, animals)" "P82358, Q86RA2" Not found Not found Acanthoscurria gomesiana (Tarantula spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Protein level Beta strand "Gm adopts a well-defined -hairpin-like struc ture, and the disulfide bonds have been reported to be important for the maintenance of this structure." 1KFP resolved by NMR. "[Ref.10942757]Function: Gomesin bound to the cell surface of cryptococci neoformans, which resulted in cell death associated with membrane permeabilization (FEMS Microbiol Lett. 2007 Sep;274(2):279-86). Also, this peptide triggers SH-SY5Y cell death through L-type channel calcium influx, MAPK/ERK, PKC and PI3K signaling and generation of reactive oxygen species (Soletti RC et al 2010 Chem Biol Interact 186: 135-43). Although represented by E, the N-terminal residue is a pyroglutamate. In hemocytes only, but not in all hemocytes observed.##[Ref.28741926]Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.10942757]Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 ?M), Bacillus cereus (MIC=6.25-12.5 ?M), Bacillus megaterium (MIC=0.2-0.4 ?M), Bacillus thuringiensis (MIC=1.6-3.15 ?M), Enterococcus faecalis (MIC=6.2-12.5 ?M), Listeria monocytogenes (MIC=0.8-1.6 ?M), Micrococcus luteus (MIC=0.4-0.8 ?M), Pediococcus acidolacrici (MIC=3.15-6.25 ?M), Staphylococcus aureus (MIC=1.6-3.15 ?M), S. epidermidis (MIC=0.8-1.6 ?M), S. haemolyticus (MIC=0.8-1.6 ?M), S. saprophyticus (MIC=0.8-1.6 ?M), Streptococcus pyogenes (MIC=1.6-3.15 ?M), Nocardia asteroides (MIC=1.6-3.15 ?M);##Gram-negative bacteria: Alcaligenes faecalis (MIC>100 ?M), Escherichia coli 1106 (MIC=0.8-1.6 ?M), E. coli D22 (MIC=0.4-0.8 ?M), E. coli D31 (MIC=0.8-1.6 ?M), E. coli SBS363 (MIC=0.4-0.8 ?M), Erwinia carolovora carolovora (MIC=3.15-6.25 ?M), Enterobacter cloacae beta 12 (MIC=3.15-6.25 ?M), Klebsiella pneumoniae (MIC=3.15-6.25 ?M), Pseudomonas aeruginosa (MIC=1.6-3.15 ?M), Salmonella typhimurium (MIC=0.8-1.6 ?M), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 ?M).##Fungi: Alternaria brassicola (MIC=0.4-0.8 ?M), Aspergillus fumigatus (MIC=1.6-3.15 ?M), Beauveria bassiana (MIC=12.5-25 ?M), Fusarium culmorum (MIC=0.4-0.8 ?M), F. oxysporum (MIC=0.4-0.8 ?M), Neurospora crassa (MIC=0.4-0.8 ?M), Nectria haematococca (MIC=0.2-0.4 ?M), Tricoderma viridae (MIC=0.4-0.8 ?M), Tricophvton mentagrophytes (MIC=0.8-1.6 ?M), C. albicans (MIC=0.15-0.3 ?M), C. glabrata (MIC=12.5-25 ?M), C. tropicalis (MIC=3.15-6.25 ?M), C. neoformans (MIC=0.8-1.6 ?M), Saccharomyces cerevisiae (MIC=1.6-3.15 ?M).##[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 M), Klebsiella pneumoniae ATCC 700603 (MIC=32 M), Acinetobacter baumannii ATCC 19606 (MIC=4-8 M), Pseudomonas aeruginosa ATCC 27853 (MIC=8 M), Helicobacter pylori ATCC 43504 (MIC>80 M);##Fungi : Candida albicans ATCC 90028 (MIC=8-16 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 M)" "[Ref.28741926] It has 0% hemolysis at 6 M , 3% hemolysis at 10 M , 10% hemolysis at 5 M , 41.2-53.2% hemolysis at 64 M , 50% hemolysis at 100 M against human red blood cells" Cyclic pyroglutamic acid Amidation "Disulfide bond between Cys2 and Cys15,Cys6 and Cys11." L "[Ref.28741926] CC50 = 67.0 5.0 M against CRL-1739, CC50 = 3.7 0.2 M against MM96L, CC50 = 49.9 16.6M against HFF-1, CC50 =54.15.0 M against HeLa, CC50 = 3.8 0.3 M against K-562." Not found 10942757##28741926 J Biol Chem. 2000 Oct 27;275(43):33464-33470.##ACS Chem Biol.?2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Silva PI Jr, Daffre S, Bulet P.##Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" "Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.##Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties" DRAMP03216 GIRCPKSWKCKAFKQRVLKRLLAMLRQHAF 30 "Oxyopinin-4a (Oxt-4a; spiders, Arthropods, animals)" "F8J4S0, P86350" Not found Not found Oxyopes takobius (Lynx spider) (Oxyopes foliiformis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found 2L3I resolved by NMR. "Function: Disrupts cell membranes through the formation of pores Probable. Has antibacterial activity. Has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: Contains one disulfide bond 4-10." [Ref.21933345]Gram-positive bacteria: S. aureus (MIC=10 ?M) and Bacillus subtilis (MIC=0.5 ?M);##Gram-negative bacteria: P. fluorescens (MIC=1 ?M) and E. coli (MIC=0.5 ?M). [Ref.21933345] EC50=7 M against human erythrocytes Cyclic Free Free Disulfide bond between Cys4 and Cys10. L No cytotoxicity information found Cell membrane (Probable) 21933345 FEBS J. 2011 Nov;278(22):4382-4393. "Dubovskii PV, Vassilevski AA, Samsonova OV, Egorova NS, Kozlov SA, Feofanov AV, Arseniev AS, Grishin EV." Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin. DRAMP03217 FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ 48 "M-oxotoxin-Ot1a (Oxyopinin-1, Oxki1; spiders, Arthropods, animals)" P83247 Not found Not found Oxyopes takobius (Lynx spider) (Oxyopes foliiformis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal" Protein level Alpha helix Not found None "Function: Disrupts cell membranes, particularly those rich in phosphocholine, through formation of pores. Has antimicrobial activity against Gram-negative bacterium E. coli, Gram-positive bacteria B. subtilis and S. aureus, and hemolytic activity against sheep erythrocytes. Has insecticidal activity against S. frugiperda ovarian cells by opening non-selective ion channels. Enhances the insecticidal activity of spider venom neurotoxic peptides." "[Ref.11976325]Gram-negative bacterium: Escherichia coli (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis, Staphylococcus aureus (MIC=6.2 ?M)." [Ref.11976325]100% hemolytic activity at 50 ?M against sheep red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11976325##15328050 J Biol Chem. 2002 Jun 28;277(26):23627-23637.##Biochim Biophys Acta. 2004 Aug 30;1664(2):182-188. "Corzo G, Villegas E, Gmez-Lagunas F, Possani LD, Belokoneva OS, Nakajima T.##Belokoneva OS, Satake H, Mal'tseva EL, Pal'mina NP, Villegas E, Nakajima T, Corzo G." "Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.##Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size." DRAMP03222 GFGALFKFLAKKVAKTVAKQAAKQGAKYVVNKQME 35 "M-ctenitoxin-Cs1a (M-CNTX-Cs1a; Cupiennin-1a; spiders, Arthropods, animals)" P83619 Belongs to the cupiennin family Not found Cupiennius salei (Wandering spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal" Protein level Alpha helix (3 helices; 11 residues) "The peptide adopts a helix-hinge-helix structure in a membrane mimicking solvent. The hinge may play a role in allowing the amphipathic N-terminal helix and polar C-terminal helix to orient independently upon membrane binding, in order to achieve maximal antibacterial efficacy.(Ref.2)" 2K38 resolved by NMR. "Function: Has antimicrobial activity. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane Function: with its amphipathic structure. Synergistically increases the insecticidal activity of CSTX-1, CSTX-9, and CSTX-13 by up to 65%. Also inhibits the formation of nitric oxide by neuronal nitric oxide synthase. LD50 is 5.9 pmol/mg on Drosophila. " "[Ref.11792701]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.31-0.63 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.31-0.63 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=0.31-0.63 ?M), Enterococcus faecalis ATCC 29212 (MIC=2.50-5.00 ?M)." [Ref.11792701]EC50=24.4 M against human red blood cells. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet calcium calmodulin 11792701##17319697 J Biol Chem. 2002 Mar 29;277(13):11208-11216.##Biochemistry. 2007 Mar 20;46(11):3576-3585. "Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W.##Pukala TL, Boland MP, Gehman JD, Kuhn-Nentwig L, Separovic F, Bowie JH." "Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).##Solution structure and interaction of cupiennin 1a, a spider venom peptide, with phospholipid bilayers." DRAMP03225 GFGSLFKFLAKKVAKTVAKQAAKQGAKYVANKHME 35 "M-ctenitoxin-Cs1d (M-CNTX-Cs1d; Cupiennin-1d; spiders, Arthropods, animals)" P83622 Belongs to the cupiennin family Not found Cupiennius salei (Wandering spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-" Protein level Not found Not found None "Function: Has antimicrobial activity. Has insecticidal activity. Probably acts by disturbing membrane Function: with its amphipathic structure. Tissue specificity: Expressed by the venom gland. Toxic dose: LD50 is 6.4 pmol/mg on Drosophila." "[Ref.11792701]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.08-0.16 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=0.16-0.31 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=0.63-1.25 ?M), Enterococcus faecalis ATCC 29212 (MIC=1.25-2.50 ?M)." [Ref.11792701]Not determined Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11792701##10669026 J Biol Chem. 2002 Mar 29;277(13):11208-11216.##Toxicon. 2000 Mar;38(3):373-380. "Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W.##Haeberli S, Kuhn-Nentwig L, Schaller J, Nentwig W." "Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).##Characterisation of antibacterial activity of peptides isolated from the venom of the spider Cupiennius salei (Araneae: Ctenidae)." DRAMP03226 SMWSGMWRRKLKKLRNALKKKLKGE 25 "M-zodatoxin-Lt1a (M-ZDTX-Lt1a; Latarcin-1, Ltc-1, Ltc1; spiders, Arthropods, animals)" Q1ELT9 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 16 residues) The Ltc1 molecule is found to form a straight uninterrupted amphiphilic helix comprising 8-23 residues. The hydrophobic surface of the Ltc1 helix is narrow-shaped and extends with no gradient along the axis. (Ref.2) 2PCO resolved by NMR. "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.5 ?M), Bacillus subtilis VKM B-501 (MIC=1.0 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 ?M), Escherichia coli MH1 (MIC=0.7?M), Pseudomonas aeruginosa PAO1 (MIC=4.1 ?M);##Fungi: Pichia pastoris GS115 (MIC=17 ?M), Saccharomyces cerevisiae Y190 (MIC>33 ?M)." [Ref.16735513]20% hemolytic activity at 80 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513##18293934 J Biol Chem. 2006 Jul 28;281(30):20983-20992.##Biochemistry. 2008 Mar 18;47(11):3525-3533. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.##Dubovskii PV, Volynsky PE, Polyansky AA, Karpunin DV, Chupin VV, Efremov RG, Arseniev AS." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.##Three-dimensional structure/hydrophobicity of latarcins specifies their mode of membrane activity." DRAMP03227 GLFGKLIKKFGRKAISYAVKKARGKH 26 "M-zodatoxin-Lt2a (M-ZDTX-Lt2a; Latarcin-2a, Ltc-2a, Ltc2a; spiders, Arthropods, animals)" Q1ELU1 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (2 helices; 18 residues) The molecule of Ltc2a is found to consist of two helical regions (residues 3-9 and 13-21) connected via a poorly ordered fragment. 2G9P resolved by NMR. "Function: Has hemolytic activity against Rabbit erythrocytes and has toxicity to ovarian insect Sf9 cells (EC50=20 ?M). Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. " "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 ?M), Bacillus subtilis VKM B-501 (MIC=0.4 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 ?M), Escherichia coli MH1 (MIC=0.7 ?M), Pseudomonas aeruginosa PAO1 (MIC=6.7 ?M);##Fungi: Pichia pastoris GS115 (MIC=6.7 ?M), Saccharomyces cerevisiae Y190 (MIC=54 ?M)." [Ref.16735513]20% hemolytic activity at 6 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513##16939228 J Biol Chem. 2006 Jul 28;281(30):20983-20992.##Biochemistry. 2006 Sep 5;45(35):10759-10767. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.##Dubovskii PV, Volynsky PE, Polyansky AA, Chupin VV, Efremov RG, Arseniev AS." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.##Spatial structure and activity mechanism of a novel spider antimicrobial peptide." DRAMP03229 SWKSMAKKLKEYMEKLKQRA 20 "M-zodatoxin-Lt3a (M-ZDTX-Lt3a; Latarcin-3a, Ltc-3a; spiders, Arthropods, animals)" Q1ELU3 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 MIC=1.2 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=2.5 ?M), Escherichia coli MH1 (MIC=6.0 ?M), Pseudomonas aeruginosa PAO1 (MIC>40 ?M);##Fungi: Pichia pastoris GS115 (MIC=20 ?M), Saccharomyces cerevisiae Y190 (MIC=20 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03230 SWASMAKKLKEYMEKLKQRA 20 "M-zodatoxin-Lt3b (M-ZDTX-Lt3b; Latarcin-3b, Ltc-3b; spiders, Arthropods, animals)" Q1ELU2 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 ?M), Bacillus subtilis VKM B-501 (MIC=2.9 ?M);Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=23 ?M), Escherichia coli MH1 (MIC=28 ?M), Pseudomonas aeruginosa PAO1 (MIC>45 ?M);##Fungi: Pichia pastoris GS115 (MIC=23 ?M), Saccharomyces cerevisiae Y190 (MIC=23 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03231 GLKDKFKSMGEKLKQYIQTWKAKF 24 "M-zodatoxin-Lt4a (M-ZDTX-Lt4a; Latarcin-4a, Ltc-4a; spiders, Arthropods, animals)" Q1ELU5 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 (MIC=1.1 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=4.5 ?M), Escherichia coli MH1 (MIC=3.2 ?M), Pseudomonas