DRAMP_ID Sequence Sequence_Length Name Swiss_Prot_Entry Family Gene Source Activity Protein_existence Structure Structure_Description PDB_ID Comments Target_Organism Hemolytic_activity Linear/Cyclic/Branched N-terminal_Modification C-terminal_Modification Other_Modifications Stereochemistry Cytotoxicity Binding_Traget Pubmed_ID Reference Author Title DRAMP18494 FIHHIIGGLFSAGKAIHRLIRRRRR 25 TP4 L0CKG3 Piscidin TP4 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) "Antibacterial, Antifungal, anticancer, wound healing, Anti-Gram+, Anti-Gram-, Antimicrobial" Protein level Alpha helix "1.0x sarkosyl can drive TP4 into a conformational change from a non-structure to an alpha-helical structure, and that LPS can also drive TP4 to an alpha-helical structure but with high hydrophobicity and low solubility." 5H2S Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. Has hemolytic activity. "[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=8 g/ml; MBC=16 g/ml), Methicillin-resistant Staphylococcus aureus (MIC=16 g/ml; MBC=32 g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa (MIC=64 g/ml; MBC=128 g/ml);##Fungi: Candida albicans (MIC=128 g/ml; MBC=128 g/ml)" "[Ref.29040295] 2% hemolysis at 0.78 g/ml, 5% hemolysis at 1.56 g/ml, 45% hemolysis at 3.13 g/ml, 85% hemolysis at 6.25 g/ml, 98% hemolysis at 12.50 g/ml, 100% hemolysis at 25.00 g/ml against mouse red blood cell" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet "bacterial outer membrane target protein, OprI-binding" 29040295 PLoS One. 2017 Oct 17;12(10):e0186442. "Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD." "Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4." DRAMP03573 IGKEFKRIVQRIKDFLRNLVPRTES 25 "LL-37(13-37)(C-terminal fragment of LL-37; Human, mammals, animals)" "P49913, Q71SN9" Not found Not found Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram-, Anticancer" Protein level Alpha helix (1 helices; 14 residues) Residues 17-29 of LL-37(13-37) are helical. 2FCG resolved by NMR. The slightly lower activity of LL-37(13-37) may result from the interference of the disordered regions with membrane binding of the peptide. "Gram-negative bacterium: Escherichia coli K12 (MIC=80 ?M).##Drug-resistant KBv cancer cells (LC50=39 ?M), Drug-sensitive KB cancer cells (LC50=40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16637646 J Am Chem Soc. 2006 May 3;128(17):5776-5785. "Li X, Li Y, Han H, Miller DW, Wang G. " Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. DRAMP03574 FKRIVQRIKDFLRNLV 16 "LL-37(17-32)(C-terminal fragment of LL-37; Human, mammals, animals)" "P49913, Q71SN9" Not found Not found Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram-, Anticancer" Protein level Not found "To achieve selective membrane targeting, D-amino acids were incorporated into LL-37(17-32). The D-peptide showed similar antibacterial activity to the L-diastereomer, it lost toxicity to human cells. " None Antibacterial and anticancer assays found that LL-37(17-32) was more active than LL-37(13-37). "Gram-negative bacteria: Escherichia coli K12(MIC=20 ?M).##Drug-resistant KBv cancer cells (LC50=30 ?M), Drug-sensitive KB cancer cells (LC50=30 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16637646 J Am Chem Soc. 2006 May 3;128(17):5776-5785. "Li X, Li Y, Han H, Miller DW, Wang G. " Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. DRAMP03829 GLKKLLGKLLKKLGKLLLK 19 GLK-19 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-, Anticancer" Synthetic Not found Not found None Function: GLK-19 showed a higher activity against Escherichia coli than human LL-37. Gram-negative bacterium: Escherichia coli K12 (MIC=10 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18957441 Nucleic Acids Res. 2009 Jan;37(Database issue):D933-937. "Wang G, Li X, Wang Z." APD2: the updated antimicrobial peptide database and its application in peptide design. DRAMP04654 IKLSPETKDNLKKVLKGAIKGAIAVAKMV 29 "H-0, Hymenochirin-1B" No entry found Unknown Not found Hymenochirus boettgeri (Congo dwarf clawed frog) "Antimicrobial, Anticancer" Experimental evidence at transcript level -helical (most likely) No detailed structure description found. None "Function: Antimicrobial, Anticancer, Immunomodulatory and Antidiabetic activity. As a cationic, amphipathic, -helical, 29-residue,host defense peptide, Hymenochirin-1B is the predominant pharmacological active component of four hymenochirins, which showed a wide range of biological activities, such as antimicrobial, anticancer, immunomodulatory, and antidiabetic activities. Surprisingly, we don't find the entry introducing Hymenochirin-1B in UniProt (2021-3-29)." "[Ref.30789695] Cancer cell lines: A549 (IC50 = 15.22 0.21 M), HCT116 (IC50 = 12.76 0.43 M), HepG2 (IC50 = 8.07 0.21 M)" "[Ref.30789695] It has 5%, 6.3%, 7.7%, 10%, 10.7%, 15.3%, 9%, 15% and 9.7% hemolysis against fresh rabbit blood cells at 0.010, 0.25, 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 25.0M" Linear Free Amidation None L No cytotoxicity information found in the reference Not found 30789695 ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. "Yulei Li,?Yihan Zhang,?Minghao Wu,?Qi Chang,?Honggang Hu,?Xia Zhao" "Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy" DRAMP29006 GLFAVIKKVASVIKGL 16 A4K14-citropin1.1 No entry found N/A N/A Synthetic construct Anticancer Synthetic form "Helicity = 61.5% in 50% 2,2,2-trifluoroethanol (TFE) aqueous solution (0.1mg/mL)" [Ref.33363118] CD analysis indicates that the helicity of intial A4K14-citropin 1.1 was 61.5% and that of the stapled peptides ranged from 13.6 to 89.8%. None "Function: Antitumor activity against A549, HCT116 and HepG2 cancer cells. A4K14-citropin 1.1 is a structurally optimized derivative of citropin-1.1 derived from amphibians' skin secreta peptide Citropin, which exhibits broad biological activities. Citropin-1.1 is Amphibian defense peptide with antibiotic and antimicrobial activity. Bowie and his team found that replacement of Asp4 and Gly14 with Ala and Lys (termed A4K14-CITROPIN 1.1) resulted in a more stable -helix than Citropin on the C-terminal section, and it led to better biologicla activities" "[Ref.33363118] Cancer cell lines: C4-2B (IC50 = 29.05 M), A549 (IC50 = 14.97 M), U87 (IC50 = 14.8 M), MCF-7 (14.16 M)" No hemolysis information or data found in the reference(s) presented in this entry Linear Acetylation Amidation None L No cytotoxicity information found in the reference 33363118 Front Chem. 2020 Dec 10;8:616147. doi: 10.3389/fchem.2020.616147. eCollection 2020. "Nan Wang, Gang Xie, Chao Liu, Wei Cong, Shipeng He, Yinghua Li, Li Fan, Hong-Gang Hu " "Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides" DRAMP29018 IKLSKKTKKNLKKVLKGAIKGAIAVAKMV 29 H-14 No entry found N/A N/A Synthetic construct Anticancer Synthetic form -helical (most likely) No detailed structure description found. None "Function: Anticancer activity. Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays" "[Ref.30789695] Cancer cell lines: A549 (IC50 = 0.98 0.11 M), HCT116 (IC50 = 1.841 0.34 M), HepG2 (IC50 = 4.54 0.25 M)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L No cytotoxicity information found in the reference Not found 30789695 ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. "Yulei Li,?Yihan Zhang,?Minghao Wu,?Qi Chang,?Honggang Hu,?Xia Zhao" "Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy" DRAMP29034 IKLSKETKDNLKKVLKGAIKGAIAVAKMV 29 [P5K]Hymenochirin-1B Not found N/A N/A Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anticancer" Synthetic form -helical (most likely) No structure indentification experiment and detailed structure description found None "Function: Antibacterial activity against Gram-positive and Gram-negative bacteria; Anticancer activity. Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays" "[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 6.25 M), S. aureus ATCC 25923 (MIC = 6.25 M), S.epidermidis RP62A (MIC = 1.6 M), S.epidermidis RP62A/1 (MIC = 1.6 M), C.albicans ATCC 90028 (MIC = 50 M);##Gram-negative bacteria: E.coli (MIC = 12.5 M), A. baumannii (MIC = 6.25 M), S. maltophilia (MIC = 3.1 M), K. pneumoniae (MIC = 12.5 M), P. aeruginosa (MIC = 25 M), P.mirabilis (MIC > 100 M).##[Ref.30789695] Cancer cell lines: A549 (IC50 = 2.35 0.31 M), HCT116 (IC50 = 8.09 0.40 M), HepG2 (IC50 = 4.28 0.38 M)" [Ref.24172540] LC?? = 205 15 M against freshly prepared human erythrocytes. Linear Free Amidation None L No cytotoxicity information found in the reference 24172540##30789695 Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.##ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. "Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon##Yulei Li,?Yihan Zhang,?Minghao Wu,?Qi Chang,?Honggang Hu,?Xia Zhao" "An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties##Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy" DRAMP29036 IKLSPETKKNLKKVLKGAIKGAIAVAKMV 29 [D9K]Hymenochirin-1B Not found N/A N/A Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anticancer" Synthetic form -helical (most likely) No structure indentification experiment and detailed structure description found None "Function: Antibacterial activity against Gram-positive and Gram-negative bacteria; Anticancer activity. Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays" "[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 M), S. aureus ATCC 25923 (MIC = 3.1 M), S.epidermidis RP62A (MIC = 1.6 M), S.epidermidis RP62A/1 (MIC = 0.8 M), C.albicans ATCC 90028 (MIC = 50 M);##Gram-negative bacteria: E.coli (MIC = 6.25 M), A. baumannii (MIC = 3.1 M), S. maltophilia (MIC = 3.1 M), K. pneumoniae (MIC = 12.5 M), P. aeruginosa (MIC = 25 M), P.mirabilis (MIC > 100 M).##[Ref.30789695] Cancer cell lines: A549 (IC50 = 1.82 0.23 M), HCT116 (IC50 = 6.50 0.32 M), HepG2 (IC50 = 4.96 0.43 M)." [Ref.24172540] LC?? = 174 12 M against freshly prepared human erythrocytes. Linear Free Amidation None L No cytotoxicity information found in the reference 24172540##30789695 Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.##ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. "Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon.##Yulei Li,?Yihan Zhang,?Minghao Wu,?Qi Chang,?Honggang Hu,?Xia Zhao." "An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties.##Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy." DRAMP29038 IKLSKETKKNLKKVLKGAIKGAIAVAKMV 29 "[P5K,D9K]Hymenochirin-1B" Not found N/A N/A Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anticancer" Synthetic form -helical (most likely) No structure indentification experiment and detailed structure description found None "Function: Antibacterial activity against Gram-positive and Gram-negative bacteria; Anticancer activity. Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays" "[Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 6.25 M), S. aureus ATCC 25923 (MIC = 3.1 M), S.epidermidis RP62A (MIC = 1.6 M), S.epidermidis RP62A/1 (MIC = 1.6 M), C.albicans ATCC 90028 (MIC = 50 M);##Gram-negative bacteria: E.coli (MIC = 6.25 M), A. baumannii (MIC = 3.1 M), S. maltophilia (MIC = 3.1 M), K. pneumoniae (MIC = 6.25 M), P. aeruginosa (MIC = 12.5 M), P.mirabilis (MIC > 100 M).##[Ref.30789695] Cancer cell lines: A549 (IC50 = 1.17 0.23 M), HCT116 (IC50 = 4.93 0.51 M), HepG2 (IC50 = 2.46 0.32 M)." [Ref.24172540] LC?? = 127 9 M against freshly prepared human erythrocytes. Linear Free Amidation None L No cytotoxicity information found in the reference 24172540##30789695 Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.##ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. "Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon.##Yulei Li,?Yihan Zhang,?Minghao Wu,?Qi Chang,?Honggang Hu,?Xia Zhao." "An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties.##Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Nov" DRAMP00795 GIPCGESCVFIPCITAAIGCSCKSKVCYRN 30 Cliotide T1 (cT1; Plant defensin) No entry found Belongs to the cyclotide family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Cliotide T1 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=7.1 ?M) and cytotoxicity against HeLa Cells (IC50=0.6 ?M). [Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. " "[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC=1.1 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC=2.7 ?M), Klebsiella pneumonia ATCC 13883 (MIC=4.7 ?M)." [Ref.21596752] HD50 = 7.1 M against human red blood cells Cyclic Free Free "There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27." L [Ref.21596752] IC50=0.6 ?M against HeLa cells. Not found 21596752 J Biol Chem. 2011 Jul 8;286(27):24275-24287. "Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP." Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. DRAMP00798 GIPCGESCVFIPCITGAIGCSCKSKVCYRN 30 Cliotide T4 (cT4; Plant defensin) No entry found Belongs to the cyclotide family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Cliotide T4 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=8.4 ?M) and cytotoxicity against HeLa Cells (IC50=0.6 ?M). [Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. " "[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC=1.3 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC=1.9 ?M), Klebsiella pneumonia ATCC 13883 (MIC=1.5 ?M)." [Ref.21596752] HD50 = 8.4 M against human red blood cells Cyclic Free Free "There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27." L [Ref.21596752] IC50=0.6 ?M against HeLa cells. Not found 21596752 J Biol Chem. 2011 Jul 8;286(27):24275-24287. "Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP." Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. DRAMP01064 AWKLFDDGV 9 Anticancerous peptide 1 (Cr-ACP1; Plants) B3EWE7 Not found Not found Cycas revoluta (Sago palm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None "Function: The synthetic peptide inhibits cell proliferation and induces apoptosis in cancer-derived cell lines Hep2 (IC50=1.5 mM) and HCT15 and, to a lesser extent, in non-cancerous NIH/3T3 cells. The mode of action is presumably an arrest in the G0/G1 phase. Antiproliferative, proapoptotic and DNA-binding activities are increased by acetylation at Ala-1 and Lys-3. Has a weak hemolytic activity against mouse erythrocytes. Has antibacterial activity. Antibacterial activity is decreased by acetylation. " "[Ref.21882228]Gram-positive bacteria: Staphylococcus epidermidis (MIC=60 ?M), Bacillus subtilis (MIC=30 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=30 ?M), EEscherichia coli strain ATCC 8739 (MIC=30 ?M)." [Ref.21882228] Hemocompatibility study revealed the effectiveness of both the peptides where it showed no significant lysis of normal RBC cells compare to positive control (Triton X-100). Cr-ACP1 induced hemolysis of 7% at the conentration of 1 mM. Linear Free Free None L [Ref.21882228] IC50 = 1.5 mM in Hep2 (Human epidermoid cancer cells); IC50 = 0.9 mM in HCT15 (human colon carcinoma cells HCT15); Cr-ACP1 induced a cell viability of 66% at the concentration of 4 mM. DNA 21882228 J Cell Biochem. 2012 Jan;113(1):184-193. "Mandal SM, Migliolo L, Das S, Mandal M, Franco OL, Hazra TK." Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties. DRAMP03024 LKLKSIVSWAKKVL 14 "Mastoparan B (MP-B; insects, arthropods, invertebrates, animals)" P21654 Not found Not found Vespa basalis (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti Mammalian cells, Anti-cancer" Not found Alpha helix Tryptophan residue in MP None Function: Mast cell degranulating peptide. Activates G proteins that couple to phospholipase C. Has hemolytic activity. "[Ref.10667861] Gram-positive bacteria: Staphylococcus epidermidis ATTC 12228 (MIC=25 ?M), Bacillus subtilis PCI 219 (MIC=25 ?M), Enterococcus faecium EFMY-28 (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli NIHJ JC-2 (MIC=50 ?M)" "[Ref.10667861] 68.2% hemolysis at the peptide concentration of 100 ?M is , 27.9% Hemolysis at 50 ?M against human red blood cells." Linear Free Amidation Free L [Ref.10667861]No cytotoxicity information found##[Ref.8555423]No cytotoxicity information found Not found 10667861##8555423 J Pept Res. 2000 Jan;55(1):51-62.##Biopolymers. 1995 Dec;36(6):793-801 "Yu K, Kang S, Park N, Shin J, Kim Y.##Park NG, Yamato Y, Lee S, Sugihara G1995" Relationship between the tertiary structures of mastoparan B and its analogs and their lytic activities studied by NMR spectroscopy.##Interaction of mastoparan-B from venom of a hornet in Taiwan with phospholipid bilayers and its antimicrobial activity DRAMP01607 GLFDIIKKIAESF 13 "Aurein-1.2 (Frogs, amphibians, animals)" P82387 Not found Not found Litoria raniformis (Southern bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Alpha helix (1 helices; 10 residues) Not found 1VM5 resolved by NMR. Function: Probably acts by disturbing membrane functions with its amphipathic structure. Aurein 1.2 is HIV active (Wang G et al. 2010 Antimicrob. Agents Chemother. (54) 1343-1346). Aurein 1.2 is also the smallest amphibian peptide to show both antibiotic and Anti-cancer activity. The aurein antibiotics show more activity towards Gram-positive than Gram-negative pathogens. Expressed by the skin dorsal glands. "Gram-positive bacteria: Bacillus cereus (MIC=100 g/ml), Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=50 g/ml), Staphylococcus aureus (MIC=8 mol/L);##Gram-negative bacteria: Pasteurella multocida (MIC=100 g/ml), Escherichia coli (MIC=8 mol/L);##Fungi: Candida albicans (MIC=32 mol/L)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found##[Ref.15572363]No cytotoxicity information found Cell membrane 10951191##15572363##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##J Biol Chem. 2005 Feb 18;280(7):5803-5811.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Wang G, Li Y, Li X.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01608 GLLDIVKKVVGAFGSL 16 "Aurein-2.1 (Frogs, amphibians, animals)" "P69016, P69017, P82388" Not found Not found Litoria aurea (Green; also golden bell frog); also Litoria raniformis (Southern bell frog) "Antimicrobial, Anti-cancer, Anti-Gram+" Protein level Not found Not found None "Function:Antimicrobial activity against Gram-positive bacteria. Probably acts by disturbing membrane functions with its amphipathic structure. The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Bacillus cereus (MIC=50 g/ml), Leuconostoc lactis (MIC=6 g/ml), Listeria innocua (MIC=6 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=100 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01612 GLFDIVKKVVGAFGSL 16 "Aurein-2.5 (Frogs, amphibians, animals)" "P69018, P69019, P82392" Not found Not found Litoria raniformis (Southern bell frog); also Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.10951191]Gram-positive bacteria: Bacillus cereus (MIC=50 g/ml), Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=50 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=100 g/ml), Staphylococcus aureus (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01613 GLFDIAKKVIGVIGSL 16 "Aurein-2.6 (Frogs, amphibians, animals)" P82393 Not found Not found Litoria raniformis (Southern bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Bacillus cereus (MIC=100 g/ml), Leuconostoc lactis (MIC=6 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=25 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Staphylococcus aureus (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01614 GLFDIVKKIAGHIAGSI 17 "Aurein-3.1 (Frogs, amphibians, animals)" "P69020, P69021, P82394" Not found Not found Litoria raniformis (Southern bell frog); also Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.10951191]Gram-positive bacteria: Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=100 g/ml), Streptococcus uberis (MIC=100 g/ml), Staphylococcus aureus (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01617 GLFDIVKKIAGHIASSI 17 "Aurein-3.2 (Frogs, amphibians, animals)" "P69022, P69023, P82395" Not found Not found Litoria aurea (green; also golden bell frog); also Litoria raniformis (blue-thighed treefrog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=6 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=50 g/ml), Staphylococcus aureus (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01618 GLFDIVKKIAGHIVSSI 17 "Aurein-3.3 (Frogs, amphibians, animals)" P82396 Not found Not found Litoria raniformis (blue-thighed treefrog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=12 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=50 g/ml), Streptococcus uberis (MIC=25 g/ml), Staphylococcus aureus (MIC=100 g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=100 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01620 GLMSSIGKALGGLIVDVLKPKTPAS 25 "Aurein-5.2 (Frogs, amphibians, animals)" "P69030, P82402, P69031, P82402" Not found Not found Litoria raniformis (blue-thighed treefrog); also Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Leuconostoc lactis (MIC=100 g/ml), Streptococcus uberis (MIC=50 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10951191]No cytotoxicity information found Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP03571 LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 37 LL-37 "P49913,Q71SN9" Belongs to the cathelicidin family CAMP Human lysosomes of polymorphonuclear leukocytes "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Alpha helix The peptide adopted 1 helices and 30 residues and a curved amphipathic helix-bend-helix motif spanning residues 2-31 followed by a disordered C-terminal tail. The helical bend is located between residues Gly-14 and Glu-16. 2K6O resolved by NMR Function:Antibacterial activity against the Gram-positive and Gram-negative bacteria. Has hemolytic activity. [Ref.29859288] Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=25??0 g/ml);ESBL-producing Escherichia coli(MIC=33.3??14.4g/ml);NDM-1 producing Acinetobacter baumannii(MIC=20.8??7.2 g/ml);##Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=133.3??57.7g/ml);##Fungi:Candida albicans (ATCC 90028)(MIC>400g/ml) [Ref.29859288] 2.9??0.7% Hemolysis at 500g/ml against human red blood cell Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 29859288 Gene. 2018 May 30. pii: S0378-1119(18)30617-6. "Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S." Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. DRAMP01746 FVQWFSKFLGRIL 13 "Temporin-L (Temporin-1Tl; temporin-Tl; TL; Frogs, amphibians, animals)" P57104 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic, Anti-cancer" Protein level Alpha helix Not found 6GS5 resolved by NMR. "Function: Antibacterial activity against Gram-negative and Gram-positive bacteria. PTM: Leucine amide at position 13. Tissue specificity: Expressed by the skin glands." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9022710 Eur J Biochem. 1996 Dec 15;242(3):788-792. "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D." "Temporins, antimicrobial peptides from the European red frog Rana temporaria." DRAMP01107 GIGTKILGGVKTALKGALKELASTYAN 27 "Maximin-1 (Toads, amphibians, animals)" "P83080, Q58T87" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity. Toxic dose: LD50 is 8.2 mg/kg by intraperitoneal injection into mice. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml);##Virus: HIV-1 (IC50=15.5 ?g/ml, EC50=21.4 ?g/ml);##Cancer cell lines: C8166 (IC50=15.3 ?g/ml), Molt-4 (IC50=24.3 ?g/ml), BIU-87 (IC50=20.5 ?g/ml), T24 (IC50=35.4 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP02397 AVPDVAFNAYG 11 Big defensin (RPD-1) P86316 Belongs to the big defensin family Not found Venerupis philippinarum (Japanese carpet shell) (Tapes japonica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro. Has antibacterial activity. "Gram-positive bacteria: Staphylococcus aureus (MIC=9.6 mg/L), Bacillus subtilis (MIC=76.8 mg/L), Micrococcus tetragenus (MIC=38.4 mg/L);##Gram-negative bacteria: Escherichia coli (MIC=76.8 mg/L), Vibrio parahaemolyticus (MIC=19.2 mg/L), Vibrio anguillarum (MIC=19.2 mg/L)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14673509 Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Dec;35(12):1145-8. "Wei YX, Guo DS, Li RG, Chen HW, Chen PX." Purification of a big defensin from Ruditapes philippinesis and its antibacterial activity. DRAMP18372 CHTNGGYCVRAICPPSARRPGSCFPEKNPCCKYM 34 mBD-2 (Murine beta-defensin 2a) No entry found Belongs to the beta-defensin family. Not found Mus musculus Anti-cancer bridge Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10922379 J Biol Chem. 2000 Oct 27;275(43):33314-20. "Jia HP, Wowk SA, Schutte BC, Lee SK, Vivado A, Tack BF, Bevins CL, McCray PB Jr." "A novel murine beta -defensin expressed in tongue, esophagus, and trachea Cancer cells." DRAMP18367 GFGSKPLDSFGLNFF 15 "Chaxapeptin (a class 2 lasso peptide; class 1 microcin, bacteriocins)" No entry found Not found Not found Streptomyces leeuwenhoekii Strain C58 "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Not found Not found None Fuction: No activity against the Gram-negative bacteria. It showed dose dependent inhibition of A549 cancer cells. Gram-positive bacteria: S. aureus and B. subtilis (MIC 30-35 ug/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 26402731 J Org Chem. 2015 Oct 16;80(20):10252-60. "Elsayed SS, Trusch F, Deng H, Raab A, Prokes I, Busarakam K, Asenjo JA, Andrews BA, van West P, Bull AT, Goodfellow M, Yi Y, Ebel R, Jaspars M, Rateb ME" "Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert" DRAMP18366 GFGSKPIDSFGLSWL 15 Sungsanpin (a class 2 lasso peptide; bacteriocins) No entry found Not found Not found a Marine Streptomyces species Anti-cancer Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23662937 J Nat Prod. 2013 May 24;76(5):873-9 "Um S, Kim YJ, Kwon H, Wen H, Kim SH, Kwon HC, Park S, Shin J, Oh DC." "Sungsanpin, a lasso peptide from a deep-sea streptomycete" DRAMP03687 FLSLIPSLVGGSISAFK 17 "TsAP-1 (T. serrulatus antimicrobial peptide 1; scorpions, arachnids, invertebrates, animals)" S6CWV8 Belongs to the?non-disulfide-bridged peptide (NDBP) superfamily.?Short antimicrobial peptide (group 4) family. Not found Tityus serrulatus (Brazilian yellow scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Anticancer activity against HI57 and H838." "[Ref.23770440] Gram-positive bacteria : Staphylococcus aureus(MIC=120 M, MBC>160 M);##Gram-negative bacteria : Escherichia coli(MIC=160 M, MBC>160 M);##Fungi : Candida albicans(MIC=160 M, MBC>160 M)" "[Ref.23770440] 0% hemolysis at 40 M , 2% hemolysis at 80 M , 5% hemolysis at 120 M , 7% hemolysis at 160 M against horse red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23770440 Biochimie. 2013 Jun 14. doi: 10.1016/j.biochi.2013.06.003. "Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C." "Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities." DRAMP03688 FLGMIPGLIGGLISAFK 17 "TsAP-2 (T. serrulatus antimicrobial peptide 2; scorpions, arachnids, invertebrates, animals)" No entry found Not found Not found Tityus serrulatus (Brazilian yellow scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Anti-cancer" Not found Not found Not found None "Function: TsAP-2 was of high potency against the Gram-positive bacterium, Staphylococcus aureus and the yeast Candida albicans." Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M).##Yeast: Candida albicans (MIC=10 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23770440 Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. "Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C." "Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities." DRAMP02926 KWCFRVCYRGICYRRCR 17 "Tachyplesin I (Tac; TP1; Horseshoe Crab, arachnids, Chelicerata, arthropods, invertebrates, animals)" P14213 Belongs to the tachyplesin/polyphemusin family. Not found Tachypleus tridentatus (Japanese horseshoe crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Anti-HIV, Anti-cancer" Protein level Beta strand This stability is due to the rigid structure imposed by the two disulfide linkages. Its amphipathic nature is closely associated with biological activity. A "1MA2, 1MA5, 6PIN, 1WO0, 1WO1, 2MDB, 2RTV resolved by NMR." "Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria, also anti-HIV activity may be due to the inhibition of virual adsorption to cells. PTM: Contains two disulfide bonds 3-16; 7-12 and Arginine amide at R17." No MICs found in DRAMP database [Ref.29870123] 9.6% hemolytic activity at 8 g/mL and 72.8% hemolytic activity at 512 g/mL against human red blood cells. Cyclic Free Amidation (Arg17) "Disulfide bond between Cys3 and Cys16,Cys7 and Cys12." L "[Ref.28429216]It possessed a cytotoxic effect on HL-60 cells (acutehuman promyelocytic leukemia cells) , K562 cells(myelogenous leukemia cells) , TSU cells (prostatecancer cells) ." Cell membrane 12369825##2229025 Biochemistry 2002; 41: 12359.##J Biochem. 1990 Aug;108(2):261-266. "Laederach A, Andreotti AH, Fulton, DB.##Muta T, Fujimoto T, Nakajima H, Iwanaga S." "Solution and Micelle-Bound Structures of Tachyplesin I and its Active Aromatic Linear Derivatives.##Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor." DRAMP00240 MRKEFHNVLSSGQLLADKRPARDYNRK 27 Pep27 (Bacteriocin) No entry found Not found Not found Streptococcus pneumoniae (Gram-negative bacteria) "Antibacterial, Anti-cancer, Antimicrobial" Not found Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16004618 Cancer Cell Int. 2005 Jul 11;5:21. "Lee DG, Hahm KS, Park Y, Kim HY, Lee W, Lim SC, Seo YK, Choi CH." Functional and structural characteristics of Anti-cancer peptide Pep27 analogues. DRAMP00301 DYPKLTFTTS 10 Malanin chain A (Plant defensin) P86600 Not found Not found Malania oleifera "Anti-cancer, Cytotoxic" Protein level Not found Not found None "Function: Significantly inhibits growth and induces an apoptotic response in HeLa cells through cell-cycle arrest at S-phase. Exhibits highly cytotoxic activities against cancer cell and non-cancer cell lines. Subunit structure: Heterodimer of an A chain and a B chain, which are crosslinked by one or more disulfide bonds. Toxic dose: LD50 values are 26.22 ?g/kg by intraperitoneal injection and 43.11 mg/kg by intragingival injection into IRC strain mice." "Cancer cell lines: HeLa (IC50=0.150.08 nM), PC-12 (IC50=7.710.24 nM), MCF-7 (IC50=11.200.02 nM), K562 (IC50=15.800.09 nM).##Non-cancer cell lines: Vero (IC50=2.790.05 nM) and Madin-Darby canine kidney cells (IC50=3.920.01 nM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19341757 Toxicon. 2009 Aug;54(2):121-127. "Yuan Y, Dai X, Wang D, Zeng X." "Purification, characterization and cytotoxicity of malanin, a novel plant toxin from the seeds of Malania oleifera." DRAMP00302 DETXTDEEFN 10 Malanin chain B (Plant defensin) P86601 Not found Not found Malania oleifera "Anti-cancer, Cytotoxic" Protein level Not found Not found None "Function: Significantly inhibits growth and induces an apoptotic response in HeLa cells through cell-cycle arrest at S-phase. Exhibits highly cytotoxic activities against cancer cell and non-cancer cell lines. Subunit structure: Heterodimer of an A chain and a B chain, which are crosslinked by one or more disulfide bonds. Toxic dose: LD50 values are 26.22 ?g/kg by intraperitoneal injection and 43.11 mg/kg by intragingival injection into IRC strain mice." "Cancer cell lines: HeLa (IC50=0.150.08 nM), PC-12 (IC50=7.710.24 nM), MCF-7 (IC50=11.200.02 nM), K562 (IC50=15.800.09 nM).##Non-cancer cell lines: Vero (IC50=2.790.05 nM) and Madin-Darby canine kidney cells (IC50=3.920.01 nM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19341757 Toxicon. 2009 Aug;54(2):121-127. "Yuan Y, Dai X, Wang D, Zeng X." "Purification, characterization and cytotoxicity of malanin, a novel plant toxin from the seeds of Malania oleifera." DRAMP00361 ITCPQVTQSLAPCVPYLISG 20 Non-specific lipid-transfer protein (LTP; Harmalin; Plants) B3EWH4 Belongs to the plant LTP family Not found Peganum harmala (Syrian rue) (Harmal peganum) "Antimicrobial, Antifungal, Antiviral, Anti-cancer" Protein level Not found Not found None "Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. Inhibits cell proliferation of cervical carcinoma cell line HeLa (IC50=2.74 ?M), gastric carcinoma cell line MGC-7 (IC50=3.13 ?M), esophageal carcinoma cell line Eca-109 (IC50=0.7 ?M) and melanoma B16 cells (IC50=1.47 ?M). Has antifungal activity. Induces caspase-dependent apoptosis in cell line Eca-109. Demonstrates inhibitory effect on HIV-1 reverse transcriptase (IC50=1.26 ?M). Biophysicochemical properties: pH dependence (Stable between pH 4 and 10); Temperature dependence (Thermostable. Retains antifungal activity between 4 degrees Celsius and 60 degrees Celsius. Activity reduced after 30 min at 80 degrees Celsius)." "Fungi: Penicillium digitatum (IC50=37.5 ?M), Alternaria alternata (IC50=1.5 ?M), Rhizopus stolonifer (IC50=8.44 ?M) and Magnaporthe grisea (IC50=12.19 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding PubMed ID is not available Submitted (MAR-2012) to UniProtKB "Ma XJ, Liu DL, Tang HS, Wang Y, Sun SR." "Purification and characterization of a novel protein from Peganum harmala seeds with antifungal, antiproliferation and anti-HIV-1 reverse transcriptase activities." DRAMP00767 GDACGETCFTGICFTAGCSCNPWPTCTRN 29 ChaC1 (Chassatide C1; Plant defensin) No entry found Belongs to the cyclotide family Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "IC50=9.8 ?M, HD50=51.9 ?M.##Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50=51.9 ?M against human type A red blood cells. Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys 4 and Cys18, Cys8 and Cys20, Cys13 and Cys26 ." L [Ref.22467870] Cytotoxicity: HeLa cells (IC50=9.8 ?M). Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00768 GIPCAESCVWIPPCTITALMGCSCKNNVCYNN 32 ChaC2 (Chassatide C2; Plant defensin) No entry found Belongs to the cyclotide family Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "IC50=2.4 ?M, HD50>25 ?M.##Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50>25 ?M against human type A red blood cells. Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys 4 and Cys21, Cys8 and Cys23, Cys13 and Cys28." L [Ref.22467870] Cytotoxicity: HeLa cells (IC50=2.4 ?M). Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00769 GASCGETCFTGICFTAGCSCNPWPTCTRN 29 ChaC4 (Chassatide C4; Plant defensin) No entry found Belongs to the cyclotide family Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "IC50=9.8 ?M, HD50=51.9 ?M.##Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50=51.9 ?M against human type A red blood cells. Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys 4 and Cys18, Cys8 and Cys20, Cys13 and Cys26 ." L [Ref.22467870] Cytotoxicity: HeLa cells (IC50=9.8 ?M). Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00770 GEYCGESCYLIPCFTPGCYCVSRQCVNKN 29 ChaC10 (Chassatide C10; Plant defensin) No entry found Belongs to the cyclotide family Not found Chassalia chartacea "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "IC50=5.0 ?M, HD50>25 ?M.##Note: IC50 (concentration that gives a survival index of 50%) and HD50 (concentration that causes 50% lysis of red blood cells)." "Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M)." [Ref.22467870] HD50>25 ?M against human type A red blood cells. Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys 4 and Cys18, Cys8 and Cys20, Cys13 and Cys25 ." L [Ref.22467870] Cytotoxicity: HeLa cells (IC50=5.0 ?M). Not found 22467870 J Biol Chem. 2012 May 18;287(21):17598-17607. "Nguyen GK, Lim WH, Nguyen PQ, Tam JP." Novel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities. DRAMP00771 GIACGESCVFLGCFIPGCSCKSKVCYFN 28 Psyle A (Cyclotides; Plants) No entry found Belongs to the cyclotide family Not found Psychotria leptothyrsa "Antimicrobial, Anti-HIV, Anti-cancer" Not found Not found Not found None Function: Cyclotide cytotoxicity on the human lymphoma cell line U-937 GTB (IC50=26 ?M). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys I and CysIV, CysII and CysV, CysIII and CysVI ." L [Ref.20575512] Cytotoxicity: the human lymphoma cell line U-937 GTB (IC50 = 26 ?M). Not found 20575512 J Nat Prod. 2010 Jul 23;73(7):1207-1213. "Gerlach SL, Burman R, Bohlin L, Mondal D, G?ransson U." "Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa." DRAMP00772 KLCGETCFKFKCYTPGCSCSYPFCK 25 Psyle C (uncyclotides; Plants) No entry found Not found Not found Psychotria leptothyrsa Anti-cancer Not found Not found Not found None Cyclotide cytotoxicity on the human lymphoma cell line U-937 GTB (IC50=3.5 ?M). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20575512 J Nat Prod. 2010 Jul 23;73(7):1207-1213. "Gerlach SL, Burman R, Bohlin L, Mondal D, G?ransson U." "Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa." DRAMP00773 GVIPCGESCVFIPCISSVLGCSCKNKVCYRD 31 Psyle E (Cyclotides; Plants) No entry found Belongs to the cyclotide family Not found Psychotria leptothyrsa Anti-cancer Not found Not found Not found None Function: Cyclotide cytotoxicity on the human lymphoma cell line U-937 GTB (IC50=0.76 ?M). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys I and CysIV, CysII and CysV, CysIII and CysVI ." L [Ref.20575512] Cytotoxicity: the human lymphoma cell line U-937 GTB (IC50=0.76 ?M). Not found 20575512 J Nat Prod. 2010 Jul 23;73(7):1207-1213. "Gerlach SL, Burman R, Bohlin L, Mondal D, G?ransson U." "Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa." DRAMP00775 GIPCGESCVFIPCLTSAIDCSCKSKVCYRN 30 Mram 8 (Plants) No entry found Belongs to the cyclotide family Not found Viola philippica Anti-cancer Not found Not found Not found None Function: The novel cyclotides show cytotoxic activity against several cancer cell lines. "Cancer cell lines: BGC-823 (IC50=1.750.05 ?M), MM96L (IC50=4.910.04 ?M), HeLa (IC50=15.50.06 ?M).##Non-cancer cell line: HFF-1 (IC50=3.190.01 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21723349 Peptides. 2011 Aug;32(8):1719-1723. "He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N." Isolation and characterization of cytotoxic cyclotides from Viola philippica. DRAMP00776 GSIPCEGSCVFIPCISAIIGCSCSNKVCYKN 31 Viphi G (Plants) No entry found Belongs to the cyclotide family Not found Viola philippica Anti-cancer Not found Not found Not found None Function: The novel cyclotides show cytotoxic activity against several cancer cell lines. Note: Activity tested together with Viphi F. "Cancer cell lines: BGC-823 (IC50=2.910.06 ?M), MM96L (IC50=1.030.03 ?M), HeLa (IC50=6.350.31 ?M).##Non-Cancer cell line: HFF-1 (IC50=1.760.12 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21723349 Peptides. 2011 Aug;32(8):1719-1723. "He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N." Isolation and characterization of cytotoxic cyclotides from Viola philippica. DRAMP00777 GSIPCGESCVFIPCISAIIGCSCSSKVCYKN 31 Viphi F (Plants) No entry found Belongs to the cyclotide family Not found Viola philippica Anti-cancer Not found Not found Not found None Function: The novel cyclotides show cytotoxic activity against several cancer cell lines. Note: Activity tested together with Viphi G. "Cancer cell lines: BGC-823 (IC50=2.910.06 ?M), MM96L (IC50=1.030.03 ?M), HeLa (IC50=6.350.31 ?M)##Non-Cancer cell line: HFF-1 (IC50=1.760.12 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21723349 Peptides. 2011 Aug;32(8):1719-1723. "He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N." Isolation and characterization of cytotoxic cyclotides from Viola philippica. DRAMP00778 GSIPCGESCVFIPCISAVIGCSCSNKVCYKN 31 Viphi E (Plants) No entry found Belongs to the cyclotide family Not found Viola philippica Anti-cancer Not found Not found Not found None Function: The novel cyclotides show cytotoxic activity against several cancer cell lines. Note: Activity tested together with Viphi D. "Cancer cell lines: MM96L (IC50=2.510.03 ?M), HeLa (IC50=5.240.40 ?M).##Non-Cancer cell line: HFF-1 (IC50=1.550.09 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21723349 Peptides. 2011 Aug;32(8):1719-1723. "He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N." Isolation and characterization of cytotoxic cyclotides from Viola philippica. DRAMP00779 GIPCGESCVFIPCISSVIGCSCSSKVCYRN 30 Viphi D (Plants) No entry found Belongs to the cyclotide family Not found Viola philippica Anti-cancer Not found Not found Not found None Function: The novel cyclotides show cytotoxic activity against several cancer cell lines. Note: Activity tested together with Viphi E. "Cancer cell lines: MM96L (IC50=2.510.03 ?M), HeLa (IC50=5.240.40 ?M).##Non-Cancer cell line: HFF-1 (IC50=1.550.09 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21723349 Peptides. 2011 Aug;32(8):1719-1723. "He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N." Isolation and characterization of cytotoxic cyclotides from Viola philippica. DRAMP00780 GSIPCGESCVFIPCISSVIGCACKSKVCYKN 31 Viphi A (Plants) No entry found Belongs to the cyclotide family Not found Viola philippica Anti-cancer Not found Not found Not found None Function: The novel cyclotides show cytotoxic activity against several cancer cell lines. "Cancer cell lines: BGC-823 (IC50=1.750.05 ?M), MM96L (IC50=4.910.04 ?M), HeLa (IC50=15.50.06 ?M).##Non-cancer cell line: HFF-1 (IC50=3.190.01 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21723349 Peptides. 2011 Aug;32(8):1719-1723. "He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N." Isolation and characterization of cytotoxic cyclotides from Viola philippica. DRAMP00781 GLPVCGETCVGGTCNTPGCGCSWPVCTRN 29 Viba 17 (Plants) No entry found Belongs to the cyclotide family Not found Viola philippica Anti-cancer Not found Not found Not found None Function: The novel cyclotides show cytotoxic activity against several cancer cell lines. Note: Activity tested together with Viba 15. "Cancer cell lines: BGC-823 (IC50=1.320.15 ?M), MM96L (IC50=3.100.06 ?M), HeLa (IC50=10.210.43 ?M).##Non-Cancer cell line: HFF-1 (IC50=2.380.09 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21723349 Peptides. 2011 Aug;32(8):1719-1723. "He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N." Isolation and characterization of cytotoxic cyclotides from Viola philippica. DRAMP00782 GLPVCGETCVGGTCNTPGCACSWPVCTRN 29 Viba 15 (Plants) No entry found Belongs to the cyclotide family Not found Viola philippica Anti-cancer Not found Not found Not found None Function: The novel cyclotides show cytotoxic activity against several cancer cell lines. Activity tested together with Viba 17. "Cancer cell lines: BGC-823 (IC50=1.320.15 ?M), MM96L (IC50=3.100.06 ?M), HeLa (IC50=10.210.43 ?M).##Non-Cancer cell line: HFF-1 (IC50=2.380.09 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21723349 Peptides. 2011 Aug;32(8):1719-1723. "He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N." Isolation and characterization of cytotoxic cyclotides from Viola philippica. DRAMP00784 GLPVCGETCVGGTCNTPGCSCSWPVCTRN 29 Varv peptide A (Varv A; Plant defensin) "Q5USN7, P58446" Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) Anti-cancer Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. Has cytotoxic activity against a variety of drug-resistant and drug-sensitive human tumor cell lines, and against primary chronic lymphocytic leukemia cells. Has weak cytotoxic activity against primary ovarian carcinoma cells or normal lymphocytes. PTM: Contains three disulfide bonds 5-19; 9-21; 14-26." "Human tumor cell lines: RPMI-8226/s (IC50=3.24 ?M), RPMI-8226/Dox40 (IC50=2.73 ?M), RPMI-8226/LR-5 (IC50=3.19 ?M), U-937GTB (IC50=6.35 ?M), U-937Vcr (IC50=4.84 ?M), ACHN (IC50=4.19 ?M), CCRF-CEM (IC50=3.56 ?M), CCRF-CEM/VM-1 (IC50=4.97 ?M), NCI-H69 (IC50=4.88 ?M), NCI-H69AR (IC50=4.89 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys26. L "[Ref.20580652] Cytotoxicity: U251(IC50 = 37.8g/mL), MDA-MB-231(IC50>10g/mL), A549(IC50>10g/mL), DU145(IC50>10g/mL), BEL-7402(IC50>10g/mL).##[Ref.14987049] Cytotoxicity: U-937 GTB (lymphoma)(IC50 = 6?M) and RPMI-8226/s (myeloma)(IC50 = 3?M)." Not found 20580652##14987049##12477048 "Peptides . 2010 Aug;31(8):1434-1440.##J Nat Prod. 2004 Feb;67(2):144-147.##Mol Cancer Ther . 2002 Apr;1(6):365-9." "Jun Tang, Conan K Wang, Xulin Pan, He Yan, Guangzhi Zeng, Wenyan Xu, Wenjun He, Norelle L Daly, David J Craik, Ninghua Tan. ##Erika Svang?rd, Ulf G?ransson, Zozan Hocaoglu, Joachim Gullbo, Rolf Larsson, Per Claeson, Lars Bohlin. ##Petra Lindholm, Ulf G?ransson, Senia Johansson, Per Claeson, Joachim Gullbo, Rolf Larsson, Lars Bohlin, Anders Backlund" Isolation and characterization of cytotoxic cyclotides from Viola tricolor. ##Cytotoxic cyclotides from Viola tricolor.##Cyclotides: a novel type of cytotoxic agents. DRAMP00785 GLPVCGETCFGGTCNTPGCSCDPWPMCSRN 30 Varv peptide B (Varv B; Plant defensin) P58447 Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) Anti-cancer Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. PTM: Contains three disulfide bonds 5-19; 9-21; 14-26." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys26. L No Cytotoxicity information found Not found 10075760 J Nat Prod. 1999 Feb;62(2):283-286. "G?ransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P." Seven novel macrocyclic polypeptides from Viola arvensis. DRAMP00786 GVPICGETCVGGTCNTPGCSCSWPVCTRN 29 Varv peptide C (Varv C; Plant defensin) P58448 Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) Anti-cancer Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. PTM: Contains three disulfide bonds 5-19; 9-21; 14-26." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10075760 J Nat Prod. 1999 Feb;62(2):283-286. "G?ransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P." Seven novel macrocyclic polypeptides from Viola arvensis. DRAMP00787 GLPICGETCVGGSCNTPGCSCSWPVCTRN 29 Varv peptide D (Varv D; Plant defensin) P58449 Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) Anti-cancer Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. PTM: Contains three disulfide bonds 5-19; 9-21; 14-26." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10075760 J Nat Prod. 1999 Feb;62(2):283-286. "G?ransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P." Seven novel macrocyclic polypeptides from Viola arvensis. DRAMP00788 GLPICGETCVGGTCNTPGCSCSWPVCTRN 29 Varv peptide E (Varv E; Plant defensin) P83835 Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) "Anti-cancer, Antiviral" Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. Has cytotoxic activity against human lymphoma U-937 GTB and human myeloma RPMI-8226/s cell lines. PTM: Contains three disulfide bonds 5-19; 9-21; 14-26." "[Ref.14987049]Human cancer cell lines: U-937 GTB (lymphoma) (IC50=4 ?M), RPMI-8226/s (myeloma) (IC50=4 ?M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=350 nM)." [Ref.20580652] HD50=6.96?M against human type O red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys26. L "[Ref.20580652] Cytotoxicity: U251(IC50=38.84g/mL), MDA-MB-231(IC50>10g/mL), A549(IC50>10g/mL), DU145(IC50>10g/mL), BEL-7402(IC50>10g/mL).##[Ref.14987049] Cytotoxicity: U-937 GTB (lymphoma)(IC50 = 4 ?M) and RPMI-8226/s (myeloma)(IC50 = 4 ?M).##[Ref.18008336]CEM-SS cells:IC50=3980 nM." Not found 18008336##10075760##14987049##20580652 Biopolymers. 2008;90(1):51-60.##J Nat Prod. 1999 Feb;62(2):283-286.##J Nat Prod. 2004 Feb;67(2):144-147.##Peptides. 2010 Aug;31(8):1434-40. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##G?ransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P.Svang.##Svang?rd E, G?ransson U, Hocaoglu Z, Gullbo J, Larsson R, Claeson P, Bohlin L.##Tang J, Wang CK, Pan X, Yan H, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N." Cyclotides as natural anti-HIV agents.##Seven novel macrocyclic polypeptides from Viola arvensis.##Cytotoxic cyclotides from Viola tricolor.##Isolation and characterization of cytotoxic cyclotides from Viola tricolor. DRAMP00789 GVPICGETCTLGTCYTAGCSCSWPVCTRN 29 Varv peptide F (Varv F; Plant defensin) P58451 Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) Anti-cancer Protein level Combine helix and strand structure Not found 2K7G resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has cytotoxic activity against a variety of drug-resistant and drug-sensitive human tumor cell lines. PTM: Contains three disulfide bonds 5-19; 9-21; 14-26." "Human tumor cell lines: RPMI-8226/s (IC50=5.90 ?M), RPMI-8226/Dox40 (IC50=3.14 ?M), RPMI-8226/LR-5 (IC50=6.31 ?M), U-937GTB (IC50=7.07 ?M), U-937Vcr (IC50=7.45 ?M), ACHN (IC50=2.63 ?M), CCRF-CEM (IC50=7.13 ?M), CCRF-CEM/VM-1 (IC50=7.15 ?M), NCI-H69 (IC50=7.49 ?M), NCI-H69AR (IC50=7.12 ?M)." [Ref.20580652] HD50=33.04?M against human type O red blood cells. Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys26. L "[Ref.20580652] Cytotoxicity: U251(IC50=44.49g/mL), MDA-MB-231(IC50>10g/mL), A549(IC50>10g/mL), DU145(IC50>10g/mL), BEL-7402(IC50>10g/mL)." Not found 10075760##12477048##19211551 J Nat Prod. 1999 Feb;62(2):283-286.##Mol Cancer Ther. 2002 Apr;1(6):365-369.##J Biol Chem. 2009 Apr 17;284(16):10672-83. "G?ransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P.##Lindholm P, G?ransson , Johansson S, Claeson P, Gullbo J, Larsson R, Bohlin L, Backlund A.##Wang CK, Hu SH, Martin JL, Sj?gren T, Hajdu J, Bohlin L, Claeson P, G?ransson U, Rosengren KJ, Tang J, Tan NH, Craik DJ." Seven novel macrocyclic polypeptides from Viola arvensis.##Cyclotides: a novel type of cytotoxic agents.##Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. DRAMP00790 GVPVCGETCFGGTCNTPGCSCDPWPVCSRN 30 Varv peptide G (Varv G; Plant defensin) P58452 Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) Anti-cancer Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. PTM: Contains three disulfide bonds 5-19; 9-21; 14-27." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10075760 J Nat Prod. 1999 Feb;62(2):283-286. "G?ransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P." Seven novel macrocyclic polypeptides from Viola arvensis. DRAMP00791 GLPVCGETCFGGTCNTPGCSCETWPVCSRN 30 Varv peptide H (Varv H; Plant defensin) P58453 Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) Anti-cancer Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. PTM: Contains three disulfide bonds 5-19; 9-21; 14-27." No MICs found in DRAMP database [Ref.20580652] HD50=7.52?M against human type O red blood cells. Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys27. L "[Ref.20580652] Cytotoxicity: U251(IC50=44.70g/mL), MDA-MB-231(IC50>10g/mL), A549(IC50>10g/mL), DU145(IC50>10g/mL), BEL-7402(IC50>10g/mL)." Not found 10075760 J Nat Prod. 1999 Feb;62(2):283-286. "G?ransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P." Seven novel macrocyclic polypeptides from Viola arvensis. DRAMP00796 GEFLKCGESCVQGECYTPGCSCDWPICKKN 30 Cliotide T2 (cT2; Plant defensin) No entry found Belongs to the cyclotide family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None Function: Cliotide T2 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. Cliotide T2 was relatively nonhemolytic (HD50>100 ?M) . "[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC>100 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC>100 ?M), Klebsiella pneumonia ATCC 13883 (MIC>100 ?M)." [Ref:21596752] HD50>100 ?M against human type A erythrocytes Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys I and CysIV, CysII and CysV, CysIII and CysVI." L [Ref.21596752] Cytotoxicity: HeLa Cells (IC50=8.0 ?M). Not found 21596752 J Biol Chem. 2011 Jul 8;286(27):24275-24287. "Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP." Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. DRAMP00797 GLPTCGETCTLGTCYVPDCSCSWPICMKN 29 Cliotide T3 (cT3; Plant defensin) No entry found Belongs to the cyclotide family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Cliotide T3 shows stronger antimicrobial activity against the Gram-negative bacteria than the Gram-positive bacteria. It also has hemolytic activity against human type A erythrocytes (HD50=13.1 ?M) and cytotoxicity against HeLa Cells (IC50=2.0 ?M). [Note: HD50 refers to the peptide concentration that causes 50% lysis of red blood cells; IC50 refers to the peptide concentration that causes 50% death of HeLa cells]. " "[Ref.21596752]Gram-positive bacteria: Staphylococcus aureus ATCC12600, Enterococcus faecalis ATCC 47077 (less active);##Gram-negative bacteria: Escherichia coli ATCC 700926 (MIC>100 ?M), Pseudomonas aeruginosa ATCC 39018 (MIC>100 ?M), Klebsiella pneumonia ATCC 13883 (MIC>100 ?M)." [Ref:21596752] HD50=13.1 ?M against human type A erythrocytes Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys I and CysIV, CysII and CysV, CysIII and CysVI." L [Ref.21596752] Cytotoxicity: HeLa Cells (IC50=2.0 ?M). Not found 21596752 J Biol Chem. 2011 Jul 8;286(27):24275-24287. "Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP." Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. DRAMP00924 PGLGFY 6 Cyclopeptide E (Plant defensin) P85003 Not found Not found Annona cherimola (Custard apple) (Cherimoya) "Anti-cancer, Cytotoxic" Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. Has cytotoxic activity against human nasopharyngeal carcinoma. PTM: This is a cyclic peptide." Human nasopharyngeal carcinoma (IC50=17 nM). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16040066 Phytochemistry. 2005 Oct;66(19):2376-2380. "Wl A, Zhang Y, Brouard JP, Pousset JL, Bodo B." Two cyclopeptides from the seeds of Annona cherimola. DRAMP01609 GLFDIVKKVVGALGSL 16 "Aurein-2.2 (Frogs, amphibians, animals)" P82389 Not found Not found Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Alpha helix Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Bacillus cereus (MIC=100 g/ml), Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=12 g/ml), Micrococcus luteus (MIC=25 g/ml), , Staphylococcus epidermidis (MIC=25 g/ml), Streptococcus uberis (MIC=100 g/ml), Staphylococcus aureus (MIC=25 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01610 GLFDIVKKVVGAIGSL 16 "Aurein-2.3 (Frogs, amphibians, animals)" P82390 Not found Not found Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Alpha helix Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.10951191]Gram-positive bacteria: Bacillus cereus (MIC=100 g/ml), Leuconostoc lactis (MIC=25 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=100 g/ml), Staphylococcus epidermidis (MIC=25 g/ml), Staphylococcus aureus (MIC=100 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01611 GLFDIVKKVVGTLAGL 16 "Aurein-2.4 (Frogs, amphibians, animals)" P82391 Not found Not found Litoria aurea (Green; also golden bell frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Protein level Not found Not found None "Function: The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.10951191]Gram-positive bacteria: Bacillus cereus (MIC=25 g/ml), Leuconostoc lactis (MIC=12 g/ml), Listeria innocua (MIC=100 g/ml), Micrococcus luteus (MIC=25 g/ml), Staphylococcus epidermidis (MIC=25 g/ml), Streptococcus uberis (MIC=25 g/ml), Staphylococcus aureus (MIC=25 g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 10951191##15203252 Eur J Biochem. 2000 Sep;267(17):5330-5341.##Peptides. 2004 Jun;25(6):1035-1054. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01615 GLFDIVKKIAGHIA 14 "Aurein-3.1.1 (Frogs, amphibians, animals)" P69021 Not found Not found Litoria aurea (Green and golden bell frog) "Antimicrobial, Antibacterial, Anti-cancer" Protein level Not found Not found None "Function: Has antimicrobial activity against L.lactis, L.innocua, M.luteus, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10951191 Eur J Biochem. 2000 Sep;267(17):5330-5341. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ." The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. DRAMP01616 FDIVKKIAGHIAGSI 15 "Aurein-3.1.2 (Frogs, amphibians, animals)" P69021 Not found Not found Litoria aurea (Green and golden bell frog) "Antimicrobial, Antibacterial, Anti-cancer" Protein level Not found Not found None "Function: Has antimicrobial activity against L.lactis, L.innocua, M.luteus, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10951191 Eur J Biochem. 2000 Sep;267(17):5330-5341. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ." The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. DRAMP01619 FDIVKKIAGHIVSSI 15 "Aurein-3.3.1 (Frogs, amphibians, animals)" P82396 Not found Not found Litoria raniformis (Southern bell frog) "Antimicrobial, Antibacterial, Anti-cancer" Protein level Not found Not found None "Function: Antimicrobial activity against L.lactis, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10951191 Eur J Biochem. 2000 Sep;267(17):5330-5341. "Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ." The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. DRAMP02396 ACSAG 5 "OEP3121 (EP5-1;earthworm,animals)" P84182 Not found Not found Eisenia foetida (Common brandling worm) (Common dung-worm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Not found Not found None Function: Displays antimicrobial activity. The effects of EP5 on HeLa cells lead to the cancer cell's apoptosis and break down. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15253156##PubMed ID is not available "Acta Biochim Biophys Sin (Shanghai). 2004 Apr;36(4):297-302.##European Journal of Soil Biology, 2007, 43:S127-S134." "Liu YQ, Sun ZJ, Wang C, Li SJ, Liu YZ.##C Wang, Z Suna, X Zhang, G Xu." Purification of a novel antibacterial short peptide in earthworm Eisenia foetida.##A novel antimicrobial vermipeptide family from earthworm Eisenia fetida. DRAMP01978 KLKNFAIGVAQSLLNKASCKLSGQC 25 "Brevinin-2R (Frogs, amphibians, animals)" P85095 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Pelophylax ridibundus (Marsh frog) (Rana ridibunda) "Antimicrobial, Antibacterial, Anti-cancer" Protein level Not found Not found None "Function: Cytotoxicity towards malignant cells, including Jurkat (T-cell leukemia), BJAB (B-cell lymphoma), HT29/219, SW742 (colon carcinomas), L929 (fibrosarcoma), MCF-7 (breast adenocarcinoma), A549 (lung carcinoma), acts via the activation of the lysosomal-mitochondrial death pathway and autophagy-like cell death. Does not show significant hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bond 19-25." "[Swiss_Prot Entry P85095]Cytotoxic to cancer cells, acts via the activation of the lysosomal-mitochondrial death pathway and autophagy-like cell death" [Ref.18494941]2.5% hemolytic activity at 200 g/ml against sheep erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18494941 Cell Mol Med. 2008 Jun;12(3):1005-1022. "Ghavami S, Asoodeh A, Klonisch T, Halayko AJ, Kadkhoda K, Kroczak TJ, Gibson SB, Booy EP, Naderi-Manesh H, Los M." "Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway." DRAMP01111 SIGAKILGGVKTFFKGALKELASTYLQ 27 "Maximin-5 (Toads, amphibians, animals)" "P83084, Q58T60, Q58T61" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. No amidation at the C-terminus. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacterium: Klebsiella pneumoniae (MIC=3.6 g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.6 g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.2 g/ml), Bacillus megatherium (MIC=12 g/ml), Bacillus dysenteriae (MIC=12 g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=1.2 g/ml), Aspergillus flavus IFFI 4015 (MIC=12 g/ml), Penicillium uticale IFFI 2001 (MIC=12 g/ml);##Virus: HIV-1 (IC50=34.4 g/ml, EC50=39.8 g/ml);##Cancer cell lines: C8166 (IC50=34.4 g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP01110 GIGGVLLSAGKAALKGLAKVLAEKYAN 27 "Maximin-4 (Toads, amphibians, animals)" "P83083, Q58T42, Q58T44, Q58T52, Q58T62, Q58T77, Q58T79" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. 2MHW resolved by NMR "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2.7 ?g/ml), Klebsiella pneumoniae (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=2.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 ?g/ml), Bacillus megatherium (MIC=1.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=15 ?g/ml);##Virus: HIV-1 (IC50=24.2 ?g/ml, EC50=21.9 ?g/ml);##Cancer cell lines: C8166 (IC50=24.2 ?g/ml), Molt-4 (IC50=35.4 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP01109 GIGGKILSGLKTALKGAAKELASTYLH 27 "Maximin-3 (Toads, amphibians, animals)" "P83082, Q58T40, Q58T43, Q58T46, Q58T48, Q58T64, Q58T65, Q58T68, Q58T69" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity. No amidation at the C-terminus. Toxic dose: LD50 is 4.3 mg/kg by intraperitoneal injection into mice. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.9 ?g/ml), Klebsiella pneumoniae (MIC=3.1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=1.5 ?g/ml), Bacillus megatherium (MIC=0.9 ?g/ml), Bacillus dysenteriae (MIC=0.9 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=15 ?g/ml);##Virus: HIV-1 (IC50=11.4 ?g/ml, EC50=1.5 ?g/ml);##Cancer cell lines: C8166 (IC50=11.4 ?g/ml), Molt-4 (IC50=25.2 ?g/ml), BIU-87 (IC50=28 ?g/ml), T24 (IC50=18 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP02472 LCPLDVLQLSSELLDIDGNEVEASRILSDITAFGGIRCPLTVVQSRGIGTIISSPYRFIAEGHPLSLKDMDGWFRVSDDEFNNYK 85 Turmerin (Plants) P85278 Not found Not found Curcuma longa (Turmeric) (Curcuma domestica) "Anti-cancer, Antiplasmodial" Protein level Not found Not found None "Function: Has anticarcinogenic activity, prevents transformation of DMBA-treated JB6 cells. Has antipromoter activity, prevents promotion by tetradecanoyl phorbal acetate (TPA) in JB6 cells. Prevents tertiary butyl hydroperoxide-induced mutagenesis. Protects AT base pairs and shows antimutagenesis activity in TA102 and TA104 S.typhimurium mutagenesis tests. Inhibits paw edema formation induced by phospholipase A2 in Swiss Wistar mice. Prevents the release of arachidonate, the parent compound for the synthesis of prostaglandins and prostacyclins. Has antimalarial activity, kills P. falciparum. Has antivenom activity, nullifies the lethal effects of N.naja venom and inhibits phospholipase A2 present in N.naja venom. Has antifungal activity, inhibits cilia formation by A.niger. Is not toxic or allergenic. Sequence similarities: Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family. [View classification] Biophysicochemical properties: Temperature dependence (Stable for 7 days at room temperature and for 30 days at 4 degrees Celsius. Remains active after incubation at 100 degrees Celsius for 3 hours). Caution: The order of the first peptide shown is Not found." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1731625##18177267 Arch Biochem Biophys. 1992 Feb 1;292(2):617-623.##Biol Chem. 2008 Mar;389(3):299-303. "Srinivas L, Shalini VK, Shylaja M.##Chethankumar M, Srinivas L." "Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa].##New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L." DRAMP02989 VNWKKVLGKIIKVAK 15 "Lasioglossin LL-I (Insects, animals)" No entry found Not found Not found Lasioglossum laticeps (Eusocial Bee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Active against B. subtilis, S. aureus, P. aeruginosa, and E. coli. Low hemolytic toxicity." "[Ref.19591185]Gram-positive bacteria:?B. subtilis(MIC=0.8 M), S. aureus(MIC=14.3 M);##Gram-negative bacteria:?P. aeruginosa(MIC=15.8 M), E. coli(MIC=1.7 M)." [Ref.19591185]LC50>200 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19591185 Chembiochem. 2009 Aug 17;10(12):2089-2099. "Cerovsk? V, Budesnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov J, Borovickov L, Fuck V, Bednrov L, Votruba I, Straka J." Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae. DRAMP02990 VNWKKILGKIIKVAK 15 "Lasioglossin LL-II (Insects, animals)" No entry found Not found Not found Lasioglossum laticeps (Eusocial Bee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Active against B. subtilis, S. aureus, P. aeruginosa, and E. coli. Low hemolytic toxicity." "[Ref.19591185]Gram-positive bacteria:?B. subtilis(MIC=0.7 M), S. aureus(MIC=9.0 M);##Gram-negative bacteria:?P. aeruginosa(MIC=14.4 M), E. coli(MIC=1.4 M)." [Ref.19591185]LC50>200 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19591185 Chembiochem. 2009 Aug 17;10(12):2089-2099. "Cerovsk? V, Budesnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov J, Borovickov L, Fuck V, Bednrov L, Votruba I, Straka J." Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae. DRAMP02991 VNWKKILGKIIKVVK 15 "Lasioglossin LL-III (Insects, animals)" No entry found Not found Not found Lasioglossum laticeps (Eusocial Bee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Not found Not found Not found None "Function: Active against B. subtilis, S. aureus, P. aeruginosa, and E. coli. Low hemolytic toxicity." "[Ref.19591185]Gram-positive bacteria:?B. subtilis(MIC=0.7 M), S. aureus(MIC=3.9 M);##Gram-negative bacteria:?P. aeruginosa(MIC=18.7 M), E. coli(MIC=1.4 M)." [Ref.19591185]LC50>220 M against rat red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19591185 Chembiochem. 2009 Aug 17;10(12):2089-2099. "Cerovsk? V, Budesnsk? M, Hovorka O, Cvacka J, Voburka Z, Slaninov J, Borovickov L, Fuck V, Bednrov L, Votruba I, Straka J." Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae. DRAMP18198 GFGSKPLDSFGLNFF 15 Chaxapeptin A0A0F7VRL1 Not found ls3A sle2_130 Streptomyces leeuwenhoekii Strain C58 "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Not found Not found 2N5C resolved by NMR "Function: Active against Gram-positive strains, S. aureus and B. subtilis (MIC 30-35 ug/mL), and no activity against the Gram-negative bacteria. It also showed dose dependent inhibition of A549 cancer cells." S. aureus and B. subtilis (MIC 30-35 ug/mL) No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 26402731 J Org Chem.80(20):10252-60(2015) "Elsayed SS, Trusch F, Deng H, Raab A, Prokes I, Busarakam K, Asenjo JA, Andrews BA, van West P, Bull AT, Goodfellow M, Yi Y, Ebel R, Jaspars M, Rateb ME." "Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert." DRAMP04130 FVDLKKIANIINSIFKK 17 LK1 (Temporin-1CEa analog peptide) No entry found Not found Not found Synthetic construct Anti-cancer Synthetic Not found Not found None Function: Has anticancer activity. "Cancer cell lines: MCF-7 (IC50=20.97 ?M), Bcap-37 (IC50=18.7 ?M), MDA-MB-231 (IC50=66.4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23609760 Arch Pharm Res. 2013 Apr 23. "Yang QZ, Wang C, Lang L, Zhou Y, Wang H, Shang DJ." "Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa." DRAMP04131 FKDLKKIANIINSIFKK 17 LK2(5) (Temporin-1CEa analog peptide) No entry found Not found Not found Synthetic construct Anti-cancer Synthetic Not found Not found None Function: Has anticancer activity. "Cancer cell lines: MCF-7 (IC50=44.7 ?M), Bcap-37 (IC50=83.49 ?M), MDA-MB-231 (IC50=894.7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23609760 Arch Pharm Res. 2013 Apr 23. "Yang QZ, Wang C, Lang L, Zhou Y, Wang H, Shang DJ." "Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa." DRAMP04132 FVKLKKIANIINSIFKK 17 LK2(6) (Temporin-1CEa analog peptide) No entry found Not found Not found Synthetic construct Anti-cancer Synthetic Not found Not found None Function: Has anticancer activity. "Cancer cell lines: MCF-7 (IC50=15.54 ?M), MDA-MB-231 (IC50=85.41 ?M), Bcap-37 (IC50=18.9 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23609760 Arch Pharm Res. 2013 Apr 23. "Yang QZ, Wang C, Lang L, Zhou Y, Wang H, Shang DJ." "Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa." DRAMP04133 FKKLKKIANIINSIFKK 17 LK3 (Temporin-1CEa analog peptide) No entry found Not found Not found Synthetic construct Anti-cancer Synthetic Not found Not found None Function: Has anticancer activity. "Cancer cell lines: MCF-7 (IC50=27.72 ?M), MDA-MB-231 (IC50=224.8 ?M), Bcap-37 (IC50=25.04 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23609760 Arch Pharm Res. 2013 Apr 23. "Yang QZ, Wang C, Lang L, Zhou Y, Wang H, Shang DJ." "Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa." DRAMP04134 FVKLKKILNIINSIFKK 17 LK2(6)A(L) (Temporin-1CEa analog peptide) No entry found Not found Not found Synthetic construct Anti-cancer Synthetic Not found Not found None Function: Has anticancer activity. "Cancer cell lines: MCF-7 (IC50=9.01 ?M), MDA-MB-231 (IC50=34.74 ?M), Bcap-37 (IC50=10.52 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23609760 Arch Pharm Res. 2013 Apr 23. "Yang QZ, Wang C, Lang L, Zhou Y, Wang H, Shang DJ." "Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa." DRAMP04135 FVKLKKILNIILSIFKK 17 LK2(6)AN(2L) (Temporin-1CEa analog peptide) No entry found Not found Not found Synthetic construct Anti-cancer Synthetic Not found Not found None Function: Has anticancer activity. "Cancer cell lines: MCF-7 (IC50=11 ?M), MDA-MB-231 (IC50=41.55 ?M), Bcap-37 (IC50=9.39 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23609760 Arch Pharm Res. 2013 Apr 23. "Yang QZ, Wang C, Lang L, Zhou Y, Wang H, Shang DJ." "Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa." DRAMP02126 FIGSALKVLAGVLPSIVSWVKQ 22 "Melittin-like peptide (MLP; Frogs, amphibians, animals)" P56924 Not found Not found Rana temporaria (European common frog) "Defense response, Anti-cancer, Protein kinase inhibitor activity" Protein level Not found Not found None "Function: Peptide has cellular defense response, inflammatory response, behavioral defense response, defense response to tumor cell, defense response by callose deposition, clearance of foreign intracellular nucleic acids, innate immune response, defense response by cell wall thickening, defense response to other organism, protein serine/threonine kinase inhibitor activity, calcium-dependent protein kinase inhibitor activity, protein tyrosine kinase inhibitor activity in GO analysis. Has hemolytic activity. PTM: Glutamine amide at position 22. Tissue specificity: Expressed by the skin dorsal glands." No MICs found in DRAMP database [Ref.9022710] LC=0.5 ?M against human red blood cells. (LC: Lethal concentration) Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9022710 Eur J Biochem. 1996 Dec 15;242(3):788-792. "Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D." "Temporins, antimicrobial peptides from the European red frog Rana temporaria." DRAMP18147 LKCNKLVPLFYKTCPAGKNL 20 Cytotoxin drCT-1 (drCT-I; Fragment) P0C5H4 Belongs to the snake three-finger toxin family Not found Daboia russelii (Russel's viper) (Vipera russelii) "Anti-cancer, Cytotoxic" Protein level Not found Not found None "Function: This three-finger cytotoxin has antiproliferative, cytotoxic and apoptotic activitieS. Both in vivo and in vitro experimental results suggests that this protein possess anticancer potential. Also shows neurotoxicity, cardiotoxicity and myotoxicity." IC50=8.9 ??g/ml for U937 and 6.7 ??g/ml for K562 No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17055549##16511326 Toxicon 49:46-56 (2007).##Acta Crystallogr. F 62:292-294 (2006). "Gomes A., Choudhury S. R., Saha A., Mishra R., Giri B., Biswas A.K., Debnath A., Gomes A.##Choudhury S. R., Gomes A., Gomes A., Dattagupta J.K., Sen U." "A heat stable protein toxin (drCT-I) from the Indian Viper (Daboiarusselli russelli) venom having antiproliferative, cytotoxic andapoptotic activitieS. ##Purification, crystallization and preliminary X-ray structuralstudies of a 7.2 kDa cytotoxin isolated from the venom of Daboiarusselli russelli of the Viperidae family." DRAMP18491 RWKIFKKIEKMGRNIRDGIVKAGPAIEVLGSAKAIGK 37 "CecropinXJ (Insects, arthropods, invertebrates, animals)" No entry found Belongs to the cecropin family Not found Bombyx mori "Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer" Not found Not found Not found None Function: Antimicrobial activity against Gram-positive and Gram-negative bacteria. Gram-positive bacteria: Staphylococcus aureus (MIC= 1.81 No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23500722 Protein Expr Purif. 2013 Jul;90(1):47-54. "Xia L, Liu Z, Ma J, Sun S, Yang J, Zhang F." "Expression, purification and characterization of cecropin antibacterial peptide from Bombyx mori in Saccharomyces cerevisiae." DRAMP03575 FKRIVQRIKDFLR 13 "LL-37(17-29) (C-terminal fragment of LL-37, LL; Human, mammals, animals)" P49913 Belongs to truncated LL-37. Not found Homo sapiens "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer" Protein level Alpha helix##Random coil Not found 2FBS resolved by NMR. "Function: LL-37(17-29) became slightly less active than the longer ones, indicating that the truncated hydrophobic residues L31 and V32 also play a role in interaction with human cells. Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria." "[Ref.16637646] Gram-negative bacterium: Escherichia coli K12(MIC=40 M);##Drug-resistant KBv cancer cells (LC50=60 M), Drug-sensitive KB cancer cells (LC50=57 M).##[Ref.28178190]Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=16 M), S. faecalis ATCC 29212 (MIC=32 M), Bacillus subtilis CMCC 63501 (MIC=16 M), Staphylococcus epidermidis ATCC 12228 (MIC=8 M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 M), Escherichia coli UB 1005 (MIC=16 M), Pseudomonas aeruginosa ATCC 27853 (MIC=8 M), Pseudomonas aeruginosa PAO1 (MIC=16 M), Salmonella typhimurium ATCC 14028 (MIC=32 M), Salmonella typhimurium ATCC 7731 (MIC=16 M). [Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC=40 M);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=5 M)" [Ref.28161291] HC50>256 M against human red blood cells. [Ref.23894079] MHC10=160 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16637646##28178190##28161291##23894079 J Am Chem Soc. 2006 May 3;128(17):5776-5785.##Int J Mol Sci. 2017 Feb 6;18(2). pii: E339. ##Biochim Biophys Acta Biomembr.?2017 May;1859(5):722-733.##ChemMedChem.?2013 Oct;8(10):1638-42. "Li X, Li Y, Han H, Miller DW, Wang G. ##Tan T, Wu D, Li W, Zheng X, Li W, Shan A.##Rajasekaran G,?Kim EY,?Shin SY##Son M,?Lee Y,?Hwang H,?Hyun S,?Yu J" "Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. ##High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7.##LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity. ##Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of -helical amphipathic peptides." DRAMP18517 KWKSFLKTFKSLKKTVLHTLLkAISS 26 K14D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: K14D against HeLa cells. D-Lysine replace L-Lysine at the position 14 on the polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=1.520.05 mol/L) [Ref.22837667]MHC=5.200.02 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18518 KWKSFLkTFKSLKkTVLHTLLKAISS 26 K22D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: K22D against HeLa cells. D-Lysine replace L-Lysine at the position 22 on the polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=1.390.02 mol/L) [Ref.22837667]MHC=20.810.10 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18519 KWKSFLKTFKSLKkTVLHTLLkAISS 26 K7D/K14D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: K7D/K14D against HeLa cells. D-lysine replace L-Lysine at the position 7 and 14 on the polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=2.060.01 mol/L) [Ref.22837667]MHC=20.810.15 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18520 KWKSFLkTFKSLKkTVLHTLLkAISS 26 K14D/K22D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: K14D/K22D against HeLa cells. D-Lysine replace L-Lysine at the position 14 and 22 on the polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=1.400.09 mol/L) [Ref.22837667]MHC=20.810.06 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18521 KWKSFLkTFkSLKkTVLHTLLkAISS 26 K7D/K14D/K22D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None "Function: K7D/K14D/K22D against HeLa cells. D-Lysine replace L-Lysine at the position 7,14 and 22 on the polar face of peptide A12L/A20L. Has hemolytic activity." [Ref.22837667]Cancer cell: HeLa cell (IC50=4.450.19 mol/L) [Ref.22837667]MHC=81.310.17 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18522 KWKSFLkTFkSLKkTVLHTLLkAISS 26 K7D/K10D/K14D/K22D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None "Function: K7D/K10D/K14D/K22D against HeLa cells. D-Lysine replace L-Lysine at the position 7,10,14 and 22 on the polar face of peptide A12L/A20L. Has hemolytic activity." [Ref.22837667]Cancer cell: HeLa cell (IC50=4.790.23 mol/L) [Ref.22837667]MHC=325.200.82 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18523 KWkSFLkTFkSLKkTVLHTLLkAISS 26 K3D/K7D/K10D/K14D/K22D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None "Function: K3D/K7D/K10D/K14D/K22D against HeLa cells. D-Lysine replace L-Lysine at the position 3,7,10,14 and 22 on the polar face of peptide A12L/A20L. Weak hemolytic activity." [Ref.22837667]Cancer cell: HeLa cell (IC50=20.410.64 mol/L) [Ref.22837667]MHC>325.20 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18524 kWkSFLkTFkSLKkTVLHTLLkAISS 26 K1D/K3D/K7D/K10D/K14D/K22D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None "Function: K1D/K3D/K7D/K10D/K14D/K22D against HeLa cells. D-Lysine replace L-Lysine at the position 1,3,7,10,14 and 22 on the polar face of peptide A12L/A20L. Weak hemolytic activity." [Ref.22837667]Cancer cell: HeLa cell (IC50=18.070.48 mol/L) [Ref.22837667]MHC>325.20 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18525 KWKSFLKTFKSLKKTVLHTLLKAISS 26 L6D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: L6D against HeLa cells. D-Leucine replace L-Leucine at the position 6 on the non-polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=2.230.10 mol/L) [Ref.22837667]MHC=10.400.08 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18526 KWKSFLKTFKSLKKTVLHTLLKAISS 26 L12D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: L12D against HeLa cells. D-Leucine replace L-Leucine at the position 12 on the non-polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=2.630.07 mol/L) [Ref.22837667]MHC=20.810.03 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18527 KWKSFLKTFKSLKKTVLHTLLKAISS 26 L20D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: L20D against HeLa cells. D-Leucine replace L-Leucine at the position 20 on the non-polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=2.330.06 mol/L) [Ref.22837667]MHC=20.810.13 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18528 KWKSFlKTFKSlKKTVLHTLLKAISS 26 L6D/L12D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: L6D/L12D against HeLa cells. D-Leucine replace L-Leucine at the position 6 and 12 on the non-polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=3.010.08 mol/L) [Ref.22837667]MHC=20.810.10 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18529 KWKSFLKTFKSlKKTVLHTlLKAISS 26 L12D/L20D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None Function: L12D/L20D against HeLa cells. D-Leucine replace L-Leucine at the position 12 and 20 on the non-polar face of peptide A12L/A20L. Has hemolytic activity. [Ref.22837667]Cancer cell: HeLa cell (IC50=3.140.06 mol/L) [Ref.22837667]MHC=81.310.43 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18530 KWKSFlKTFKSlKKTVLHTlLKAISS 26 L6D/L12D/L20D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None "Function: L6D/L12D/L20D against HeLa cells. D-Leucine replace L-Leucine at the position 6,12 and 20 on the non-polar face of peptide A12L/A20L. Has hemolytic activity." [Ref.22837667]Cancer cell: HeLa cell (IC50=7.800.26 mol/L) [Ref.22837667]MHC=162.610.19 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18531 KWKSFlKTFKSlKKTVlHTlLKAISS 26 L6D/L12D/L17D/L20D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None "Function: L6D/L12D/L17D/L20D against HeLa cells. D-Leucine replace L-Leucine at the position 6,12,17 and 20 on the non-polar face of peptide A12L/A20L. Has hemolytic activity." [Ref.22837667]Cancer cell: HeLa cell (IC50=9.690.38 mol/L) [Ref.22837667]MHC=81.311.05 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18532 KWKSFlKTFKSlKKTVlHTllKAISS 26 L6D/L12D/L17D/L20D/L21D (A12L/A20L peptide derivative) No entry found Derived from the framework peptide A12L/A20L Not found Synthetic construct Anti-Cancer Synthetic Alpha helix Not found None "Function: L6D/L12D/L17D/L20D/L21D against HeLa cells. D-Leucine replace L-Leucine at the position 6,12,17,20 and 21 on the non-polar face of peptide A12L/A20L. Weak hemolytic activity." [Ref.22837667]Cancer cell: HeLa cell (IC50=12.88 0.15 mol/L) [Ref.22837667]MHC>325.20 mol/L against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22837667 Int J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. "Huang YB, He LY, Jiang HY, Chen YX." Role of helicity on the anticancer mechanism of action of cationic-helical peptides. DRAMP18658 FLPIVAKLLSGLL 13 "Temporin-PE (Edible frogs, amphibians, animals)" A0A2H4WAJ8 Not found Not found Pelophylax kl.esculentus(Europe edible frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-cancer, Anti-Gram-" Protein level Alpha helix Not found None "Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.Has hemolytic activity." "[Ref.29191658]Gram-positive bacteria: Staphylococcus aureus (MIC=2.0 M), Methicillin-resistant Staphylococcus aureus (MIC=4.0 M), Enterococcus faecalis (MIC=8.0 M);##Gram-negative bacteria: Escherichia coli (MIC=16.0 M);##Fungus: Candida albicans (MIC=4.0 M).##Cancer cell lines: NCI-H157 (IC50=34.56 M), U251MG (IC50=25.13 M), PC-3 (IC50=38.56 M), MDA-MB-435s (IC50=33.23 M), HMEC-1 (IC50=58.62 M)." [Ref.29191658]HC50=39.64 M against horse red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 29191658 Biochem Biophys Res Commun. 2018 Jan 22;495(4):2539-2546. "Sang M, Wu Q, Xi X, Ma C, Wang L, Zhou M, Burrows JF, Chen T." "Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus." DRAMP20829 RWKIFKKIERVGQNVRDGIIKAGPAIQVLGTAKALGK 37 ABP-dHC-Cecropin A No entry found Derived from dHC Not found Synthetic construct Anti-Cancer Synthetic Alpha helix ABP-dHC-Cecropin A and its analog adopt a well-defined None Function: Anticancer activity against the human leukemia cells "[Ref.28347740] Cancer cell lines: Leukemia cell lines K562 (IC50=349.5M), Leukemia cell lines U937 (IC50=303.2M), Leukemia cell lines THP-1 (IC50=228.5M)" "[Ref.28347740] 0% hemolysis at 0M, 1% hemolysis at 800M against human red cells" Linear Free Free None L "[Ref.28347740] IC50 = 349.5 M and CI = [304.0, 399.0] M against K562 cells. ## IC50 = 303.2 M and CI =[291.2, 315.3] M against U937 cells. IC50 = 228.5 M and CI = [199.1, 258.0] M against THP-1 cells. The CI is the Confidence Interval of 90%." Not found 28347740 Eur J Pharmacol. 2017 May 15;803:138-147. "Sang M, Zhang J, Zhuge Q" Selective cytotoxicity of the antibacterial peptide ABP-dHC-Cecropin A and its analog towards leukemia cells DRAMP20830 RWKIFKKIERVGQNVRDGIIKAGKAIQVLGTAKALGK 37 ABP-dHC-Cecropin A-K No entry found Derived from dHC Not found Synthetic construct Anti-Cancer Synthetic Alpha helix ABP-dHC-Cecropin A and its analog adopt a well-defined None Function: Anticancer activity against the human leukemia cells "[Ref.28347740] Cancer cell lines: Leukemia cell lines K562 (IC50=184.9M), Leukemia cell lines U937 (IC50=223.9M), Leukemia cell lines THP-1 (IC50=196.1M)" "[Ref.28347740] 0% hemolysis at 0M, 1% hemolysis at 800M against human red cells" Linear Free Free None L "[Ref.28347740] IC50 = 184.9 M and CI = [185.3, 191.0] M against K562 cells. ## IC50 = 223.9 M and CI =[211.4, 236.5] M against U937 cells. IC50 = 196.1 M and CI = [170.2, 222.1] M against THP-1 cells. The CI is the Confidence Interval of 90%." Not found 28347740 Eur J Pharmacol. 2017 May 15;803:138-147. "Sang M, Zhang J, Zhuge Q" Selective cytotoxicity of the antibacterial peptide ABP-dHC-Cecropin A and its analog towards leukemia cells DRAMP29094 GPKTKAACKMACKLATCGKKPGGWKCKLCELGCDAV 36 Turgencin A C0HLN5 Not found N/A Synoicum turgens "Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-,Anti-cancer" Protein level Random coil Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. [Ref.32751755]Gram-positive bacteria:Bacillus megaterium(MIC=0.5 ?g/mL); Bacillus subtilis(MIC=1.5 ?g/mL); Corynebacterium glutamicum(MIC=1.5 ?g/mL); Micrococcus luteus(MIC=8.0 ?g/mL); Staphylococcus aureus(MIC=23.3 ?g/mL);##Gram-negative bacteria:Escherichia coli(MIC=3.0 ?g/mL); Pseudomonas aeruginosa(MIC=5.9 ?g/mL);##Fungi: Rhodotorula sp(MIC=23.2 ?g/mL);Aurobasidium pollulans(MIC=92.6 ?g/mL); Candida albicans(MIC=46.3 ?g/mL).##[Ref.31940927]Cancer:Human melanoma A2058(IC50=1.4 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation "Disulfide bond between Cys8 and Cys33, Cys12 and Cys29, Cys17 and Cys26; the 'Met' at position 10 is Methionine sulfoxide." L [Ref.31940927]Cytotoxicity: Human fibroblasts MRC-5(IC50=4.8 M). liposomes 32751755##31940927 Int J Mol Sci.2020 Jul 30;21(15):5460.##Mar Drugs. 2020 Jan 12;18(1):51. "Hansen IK?, L?vdahl T, Simonovic D, Hansen K?, Andersen AJC, Devold H, Richard CSM, Andersen JH, Str?m MB, Haug T.##Hansen IK?, Isaksson J, Poth AG, Hansen K?, Andersen AJC, Richard CSM, Blencke HM, Stensv?g K, Craik DJ, Haug T. " Antimicrobial Activity of Small Synthetic Peptides Based on the Marine Peptide Turgencin A: Prediction of Antimicrobial Peptide Sequences in a Natural Peptide and Strategy for Optimization of Potency.##Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens. DRAMP29095 GIKEMLCNMACAQTVCKKSGGPLCDTCQAACKALG 35 Turgencin B C0HLN6 Not found N/A Synoicum turgens "Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-,Anti-cancer" Protein level "Alpha helix,random coil" Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. [Ref.31940927]Gram-positive bacteria:Corynebacterium glutamicum ATCC 13032(MIC=1.6 ?M);Bacillus subtilis ATCC 23857(MIC=1.6 ?M);Staphylococcus aureus ATCC 9144(MIC>100?M);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=12.5 ?M);Pseudomonas aeruginosa ATCC 27853(MIC=25.0 ?M);##Cancer:Human melanoma A2058(IC50=4.1 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation "Disulfide bond between Cys7 and Cys31, Cys11 and Cys27, Cys16 and Cys24; the 'Met' at position 5 and 9 is Methionine sulfoxide." L [Ref.31940927]Cytotoxicity: Human fibroblasts MRC-5(IC50=7.5 M). liposomes 31940927 Mar Drugs. 2020 Jan 12;18(1):51. "Hansen IK?, Isaksson J, Poth AG, Hansen K?, Andersen AJC, Richard CSM, Blencke HM, Stensv?g K, Craik DJ, Haug T. " DRAMP29101 GFKDLLKGAAKALVKAVLF 19 Ascaphin-8 [T16A] P0CJ32 Not found N/A Synthetic construct "Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer, Antifungal" Protein level Alpha helix 45% -helix was determined from the circular dichroism spectra recorded in 50% trifluoroethanol-water. None Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans. [Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=6 ?M);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=3 ?M);##Fungi:Candida albicans ATCC 900280(MIC=6 ?M).##Cancer:human hepatoma\derived cells HepG2 (LC50=9 ?M). [Ref.18554256]Hemolysis against human erythrocytes (LC50=22 ?M). Linear Free Amidation None L [Ref.18554256]Cytotoxicity:Mouse fibroblasts L929 (LC50=5 ?M). liposomes 18554256 Chem Biol Drug Des. 2008 Jul;72(1):58-64. "Conlon JM, Galadari S, Raza H, Condamine E." "Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7." DRAMP29102 KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL 30 Hc-CATH No entry found Not found Not found Hydrophis cyanocinctus "Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer, Antifungal" Not found "Alpha helix,-sheet,random coil" "The CD spectra in H2O adopts a random-coil conformation. In the membrane-mimetic environments of SDS/H2O solutions (30C120 mm), the secondary structure components of Hc-CATH dissolved in 60 mm SDS/H2O were calculated as 59.9% -helix, 16% -sheet, 0% -turn, and 24% random coil.When dissolved in SDS/H2O solutions with serial concentrations of NaCl (at 0, 100, 200, and 400 mm), the -helix contents decreased slightly from 59.9 to 33.8% as the NaCl concentration increased. Simultaneously, the contents of the -turn (0 to 14.9%) and random coil (24 to 30.5%) increased slightly. " None "Function:The microbial killing activity of Hc-CATH is executed through the disruption of cell membrane and lysis of bacterial cells. Antimicrobial activity of Hc-CATH in the presence of a high concentration of sodium chlorideIn addition is strong. Hc-CATH exhibited potent anti-inflammatory activity by inhibiting the LPS-induced production of nitric oxide (NO) and pro-inflammatory cytokines such as TNF-, IL-1, and IL-6." "[Ref.26013823]Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=2.34 ?g/ml); Escherichia coli ATCC 25922(400 Mm NaCl,MIC=4.69 ?g/ml); Escherichia coli 1(MIC=2.34 ?g/ml);Escherichia coli 2(MIC=2.34 ?g/ml); Escherichia coli 3(MIC=2.34 ?g/ml); Escherichia coli 4(MIC=9.38 ?g/ml); Shigella dysenteriae(MIC=0.59 ?g/ml); Klebsiella pneumoniae 1(MIC=37.50 ?g/ml); Klebsiella pneumoniae 2(MIC=4.69 ?g/ml); Klebsiella pneumoniae 3(MIC=9.38 ?g/ml); Klebsiella pneumoniae 4(MIC=9.38 ?g/ml); Klebsiella pneumoniae 5(MIC=18.75 ?g/ml); Klebsiella pneumoniae 6(MIC=37.50 ?g/ml); Klebsiella pneumoniae 7(MIC=37.50 ?g/ml); Klebsiella pneumoniae 8(MIC=75.00 ?g/ml); Serratia marcescens(MIC>200 ?g/ml); Klebsiella oxytoca(MIC=4.69 ?g/ml); Proteus vulgaris(MIC>200 ?g/ml); Proteus mirabilis(MIC=4.69 ?g/ml); Acinetobacter baumannii 1(MIC>200 ?g/ml); Acinetobacter baumannii 2(MIC>200 ?g/ml); Stenotrophomonas maltophilia(MIC>200 ?g/ml); Stenotrophomonas maltophilia 2(MIC=9.38 ?g/ml); Pseudomonas aeruginosa ATCC 27853(MIC=18.75 ?g/ml); Pseudomonas aeruginosa 1 (MIC=37.50 ?g/ml ); Pseudomonas aeruginosa(MIC>200 ?g/ml); Salmonella paratyphi A(MIC=4.69 ?g/ml);##Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4.69 ?g/ml); Staphylococcus aureus 1(MIC>200 ?g/ml ); Staphylococcus aureus 2(MIC>200 ?g/ml ); Staphylococcus aureus 3(MIC>200 ?g/ml ); Staphylococcus aureus 4(MIC=4.69 ?g/ml); Staphylococcus aureus 5(MIC=4.69 ?g/ml); Bacillus cereus(MIC=9.38 ?g/ml); Bacillus subtilis(MIC=75.00 ?g/ml); Enterococcus faecium(MIC=37.50 ?g/ml); Nocardia asteroides(MIC=9.38 ?g/ml); Enterococcus faecalis(MIC>200 ?g/ml); Staphylococcus epidermidis(MIC>200 ?g/ml);##Fungi:Candida albicans 1(MIC=4.69 ?g/ml); Candida albicans 2(MIC=4.69 ?g/ml); Candida albicans 3(MIC=4.69 ?g/ml); Candida albicans 4(MIC=4.69 ?g/ml); Candida albicans 5(MIC=2.34 ?g/ml); Candida albicans 6(MIC=2.34 ?g/ml); Candida glabrata 1(MIC=2.34 ?g/ml); Candida glabrata(MIC>200 ?g/ml); Cryptococcus neoformans(MIC>200 ?g/ml); Arcyria cinerea(MIC=9.38 ?g/ml);##Pathogenic bacteria:Aeromonas sobria(MIC=2.34 ?g/ml); Aeromonas hydrophila(MIC=2.34 ?g/ml); Aeromonas veronii(MIC=2.34 ?g/ml); Vibrio vulnificus(MIC=4.69 ?g/ml ); Vibrio harveyi(MIC=9.38 ?g/ml); Vibrio fluvialis(MIC=4.69 ?g/ml); Vibrio alginolyticus(MIC=4.69 ?g/ml); Vibrio parahaemolyticus(MIC=9.38 ?g/ml); Vibrio splendidus(MIC=2.34 ?g/ml); Vibrio anguillarum(MIC=18.75 ?g/ml); Edwardsiella tarda(MIC=2.34 ?g/ml)." [Ref.26013823]5.25% Hemolysis against Human erythrocytes at 200 ?g/ml(55.12 M). Linear Free Free None L [Ref.26013823]4.70% cell death at 200 ?g/ml against Human hepatocellular carcinoma HepG2; 3.63% cell death at 200 ?g/ml against Human prostate adenocarcinoma PC-3; 1.30% cell death at 200 ?g/ml against Mouse fibroblasts L929. liposomes 26013823 J Biol Chem. 2015 Jul 3;290(27):16633-52. "Wei L, Gao J, Zhang S, Wu S, Xie Z, Ling G, Kuang YQ, Yang Y, Yu H, Wang Y." Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity and Special Mechanism. DRAMP29104 LNLKALLAVAKKIL 14 Mastoparan-C(MP-C) P01516 Not found N/A Vespa crabro "Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal" Protein level "Alpha helix,random coil" "The CD spectra in water adopts a random-coil conformation,24.85% -helix was determined in 50% TFE." None "Function:The peptide was tolerant in the presence of physiological salts.MP-C lost antimicrobial activities after incubation with 20 g/mL trypsin or chymotrypsin,indicating moderate protease resistance." "[Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=2 ?M); Staphylococcus aureus NCTC 10788(MBC=2 ?M); Staphylococcus aureus ATCC 12493(MRSA,MIC=4 ?M); Staphylococcus aureus ATCC 12493(MRSA,MBC=4 ?M); Enterococcus faecalis NCTC 12697(MIC=8 ?M); Enterococcus faecalis NCTC 12697(MBC=8 ?M);##Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=4 ?M); Escherichia coli NCTC 10418(MBC=8 ?M); Pseudomonas aeruginosa ATCC 27853(MIC=8 ?M); Pseudomonas aeruginosa ATCC 27853(MBC=16 ?M); Fungi:Candida albicans NCTC 1467(MIC=4 ?M); Candida albicans NCTC 1467(MBC=4 ?M);##Cancer:Human squamous lung carcinoma NCI-H157(IC50=13.57 ?M);Human breast adenocarcinoma MDA-MB-435S(IC50=27.70 ?M);Human prostate adenocarcinoma PC-3(IC50=6.29 ?M);Human glioblastoma U251-MG(IC50=36.65 ?M); Human breast adenocarcinoma MCF-7(IC50=25.27 ?M).##[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4 ?M); Bacillus subtilis ATCC 23857(MIC=4 ?M);##Gram-negative bacterial:Escherichia coli ATCC 25922(4.5 mM KCl and 0.004 mM FeCl3,MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(4.5 mM KCl,MIC=8 ?M); Klebsiella pneumoniae ATCC 700603(MIC=8 ?M); Escherichia coli ATCC 25922(NaCl/MgCl2=150mM/1mM,MIC=4 ?M); Pseudomonas aeruginosa ATCC 9027(NaCl/MgCl2=150mM/1mM,MIC=16 ?M); Pseudomonas aeruginosa ATCC 9027(0.004mM FeCl3,MIC=4 ?M);Escherichia coli(Rifampin-resistant strain,MIC=4 ?M)." [Ref.29904274]50% hemolysis against horse erythrocytes at 40.11 ?M.##[Ref.33285267]10% hemolysis against mouse erythrocytes at 64 ?M; 60% hemolysis against mouse erythrocytes at 256 ?M. Linear Free Amidation None L [Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=57.15 ?M).##[Ref.33285267]90% Killing against Human embryonic kidney HEK293T cells at 128 ?M; Human embryonic kidney HEK293T cells(IC50=16 ?M). liposomes 33285267##29904274 Eur J Pharm Sci. 2021 Mar 1;158:105665.##Int J Biol Sci. 2018 Apr 25;14(6):599-607. "Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J. ##Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M." Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.##Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering. DRAMP29105 CLNLKALLAVAKKILC 16 c Mastoparan-C(cMP-C) P01516 Not found N/A Synthetic construct "Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal" Protein level "Alpha helix,random coil" "76% -helix was determined from the circular dichroism spectra recorded in 50% TFE/10mM NH4AC solution,28% of the secondary structure retained an -helical domain in an aqueous environment." None Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. "[Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=32 ?M); Staphylococcus aureus NCTC 10788(MBC=64 ?M); Staphylococcus aureus ATCC 12493(MRSA,MIC=128 ?M); Staphylococcus aureus ATCC 12493(MRSA,MBC=128 ?M); Enterococcus faecalis NCTC 12697(MIC=128 ?M); Enterococcus faecalis NCTC 12697(MBC=128 ?M);##Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=32 ?M); Escherichia coli NCTC 10418(MBC=128 ?M); Pseudomonas aeruginosa ATCC 27853(MIC=32 ?M); Pseudomonas aeruginosa ATCC 27853(MBC>512 ?M);##Fungi:Candida albicans NCTC 1467(MIC=32 ?M); Candida albicans NCTC 1467(MBC=128 ?M);##Cancer:Human squamous lung carcinoma NCI-H157(IC50=7.02 ?M);Human breast adenocarcinoma MDA-MB-435S(IC50=13.87 ?M);Human prostate adenocarcinoma PC-3(IC50=13.87 ?M);Human glioblastoma U251-MG(IC50=8.56 ?M); Human breast adenocarcinoma MCF-7(IC50=13.66 ?M). " [Ref.29904274]50% hemolysis against horse erythrocytes at 9.19 ?M. Cyclic Free Amidation Disulfide bond (Cys1-Cys16) L [Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=39.53 ?M). liposomes 29904274 Int J Biol Sci. 2018 Apr 25;14(6):599-607. "Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M." Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering. DRAMP29106 RKKRRQRRRLNLKALLAVAKKIL 23 "t Mastoparan-C(tMP-C, Tat (49-57)-Mastoparan-C)" "P01516,Q76PP9" Not found N/A Synthetic construct "Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal" Protein level "Alpha helix,random coil" "28% -helix was determined from the circular dichroism spectra recorded in 50% TFE/10mM NH4AC solution,and it adopted a random coil structure in an aqueous environment." None Function:Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. "[Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=4 ?M); Staphylococcus aureus NCTC 10788(MBC=4 ?M); Staphylococcus aureus ATCC 12493(MRSA,MIC=4 ?M); Staphylococcus aureus ATCC 12493(MRSA,MBC=8 ?M); Enterococcus faecalis NCTC 12697(MIC=8 ?M); Enterococcus faecalis NCTC 12697(MBC=16 ?M);##Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=2 ?M); Escherichia coli NCTC 10418(MBC=2 ?M); Pseudomonas aeruginosa ATCC 27853(MIC=4 ?M); Pseudomonas aeruginosa ATCC 27853(MBC=4 ?M);##Fungi:Candida albicans NCTC 1467(MIC=2 ?M); Candida albicans NCTC 1467(MBC=2 ?M);##Cancer:Human squamous lung carcinoma NCI-H157(IC50=2.79 ?M);Human breast adenocarcinoma MDA-MB-435S(IC50=3.86 ?M);Human prostate adenocarcinoma PC-3(IC50=3.86 ?M);Human glioblastoma U251-MG(IC50=3.36 ?M); Human breast adenocarcinoma MCF-7(IC50=3.70 ?M). " [Ref.29904274]50% hemolysis against horse erythrocytes at 77.94 ?M. Linear Free Amidation None L [Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=9.18 ?M). liposomes 29904274 Int J Biol Sci. 2018 Apr 25;14(6):599-607. "Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M." Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering. DRAMP02980 GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE 78 "Antimicrobial peptide NK-lysin (NKL; pigs, mammals, animals)" Q29075 Not found NKL Sus scrofa (Pig) "Antimicrobial, Antibacterial, Antifungal, Antitumor" Protein level Alpha helix Not found 1NKL resolved by NMR. "Function: May be an effector molecule of cytotoxic activity. High activity against E. coli and B. megaterium, moderate against A. calcoaceticus and S. pyogenes. Has some antifungal activity against Candida albicans. Tissue specificity: Cytotoxic T and NK cells. Induction: By interleukin-2. PTM: Contains three disulfide bonds 4-76; 7-70; 35-45." "[with medium E]: Escherichia coli D21 (MIC=0.5 ?M), Escherichia coli Bd2221/75 (MIC=10 ?M), Acinetobacter calcoaceticus Ac 11 (MIC=7 ?M), Bacillus megaterium Bmll (MIC=1.6 ?M);##[without medium E]: Escherichia coli D21 (MIC=8 ?M), Escherichia coli Bd2221/75 (MIC=39 ?M), Bacillus megaterium Bmll (MIC=0.8 ?M), Streptococcus pyogenes w.t. (MIC=34 ?M), Candida albicans w.t. (MIC=31 ?M)." [Ref.7737114] It exhibits no hemolytic activity at 170 ?M against sheep red blood cells. Cyclic Free Free Disulfide bonds between Cys4 and Cys76; Cys7 and Cys70; Cys35 and Cys45. L "[Ref.7737114] NK-lysin at 50g/ml was able to give 90% lysis of 5'Cr-labelled YAC-1 cells in a medium with 2% fetal calf serum(FCS) and 75% lysis in phosphate-buffered saline(PBS), 15% lysis suspended in medium E." Lipopolysaccharide (LPS)-binding 7737114##9334742 EMBO J. 1995 Apr 18;14(8):1615-1625.##Nat Struct Biol. 1997 Oct;4(10):793-795. "Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, J?rnvall H, Mutt V, Olsson B, Wigzell H, et al.##Liepinsh E, Andersson M, Ruysschaert JM, Otting G." "NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.##Saposin fold revealed by the NMR structure of NK-lysin." DRAMP03215 ZCRRLCYKQRCVTYCRGR 18 "Gomesin (Gm; spiders, Arthropods, animals)" "P82358, Q86RA2" Not found Not found Acanthoscurria gomesiana (Tarantula spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Protein level Beta strand "Gm adopts a well-defined -hairpin-like struc ture, and the disulfide bonds have been reported to be important for the maintenance of this structure." 1KFP resolved by NMR. "[Ref.10942757]Function: Gomesin bound to the cell surface of cryptococci neoformans, which resulted in cell death associated with membrane permeabilization (FEMS Microbiol Lett. 2007 Sep;274(2):279-86). Also, this peptide triggers SH-SY5Y cell death through L-type channel calcium influx, MAPK/ERK, PKC and PI3K signaling and generation of reactive oxygen species (Soletti RC et al 2010 Chem Biol Interact 186: 135-43). Although represented by E, the N-terminal residue is a pyroglutamate. In hemocytes only, but not in all hemocytes observed.##[Ref.28741926]Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.10942757]Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 ?M), Bacillus cereus (MIC=6.25-12.5 ?M), Bacillus megaterium (MIC=0.2-0.4 ?M), Bacillus thuringiensis (MIC=1.6-3.15 ?M), Enterococcus faecalis (MIC=6.2-12.5 ?M), Listeria monocytogenes (MIC=0.8-1.6 ?M), Micrococcus luteus (MIC=0.4-0.8 ?M), Pediococcus acidolacrici (MIC=3.15-6.25 ?M), Staphylococcus aureus (MIC=1.6-3.15 ?M), S. epidermidis (MIC=0.8-1.6 ?M), S. haemolyticus (MIC=0.8-1.6 ?M), S. saprophyticus (MIC=0.8-1.6 ?M), Streptococcus pyogenes (MIC=1.6-3.15 ?M), Nocardia asteroides (MIC=1.6-3.15 ?M);##Gram-negative bacteria: Alcaligenes faecalis (MIC>100 ?M), Escherichia coli 1106 (MIC=0.8-1.6 ?M), E. coli D22 (MIC=0.4-0.8 ?M), E. coli D31 (MIC=0.8-1.6 ?M), E. coli SBS363 (MIC=0.4-0.8 ?M), Erwinia carolovora carolovora (MIC=3.15-6.25 ?M), Enterobacter cloacae beta 12 (MIC=3.15-6.25 ?M), Klebsiella pneumoniae (MIC=3.15-6.25 ?M), Pseudomonas aeruginosa (MIC=1.6-3.15 ?M), Salmonella typhimurium (MIC=0.8-1.6 ?M), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 ?M).##Fungi: Alternaria brassicola (MIC=0.4-0.8 ?M), Aspergillus fumigatus (MIC=1.6-3.15 ?M), Beauveria bassiana (MIC=12.5-25 ?M), Fusarium culmorum (MIC=0.4-0.8 ?M), F. oxysporum (MIC=0.4-0.8 ?M), Neurospora crassa (MIC=0.4-0.8 ?M), Nectria haematococca (MIC=0.2-0.4 ?M), Tricoderma viridae (MIC=0.4-0.8 ?M), Tricophvton mentagrophytes (MIC=0.8-1.6 ?M), C. albicans (MIC=0.15-0.3 ?M), C. glabrata (MIC=12.5-25 ?M), C. tropicalis (MIC=3.15-6.25 ?M), C. neoformans (MIC=0.8-1.6 ?M), Saccharomyces cerevisiae (MIC=1.6-3.15 ?M).##[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 M), Klebsiella pneumoniae ATCC 700603 (MIC=32 M), Acinetobacter baumannii ATCC 19606 (MIC=4-8 M), Pseudomonas aeruginosa ATCC 27853 (MIC=8 M), Helicobacter pylori ATCC 43504 (MIC>80 M);##Fungi : Candida albicans ATCC 90028 (MIC=8-16 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 M)" "[Ref.28741926] It has 0% hemolysis at 6 M , 3% hemolysis at 10 M , 10% hemolysis at 5 M , 41.2-53.2% hemolysis at 64 M , 50% hemolysis at 100 M against human red blood cells" Cyclic pyroglutamic acid Amidation "Disulfide bond between Cys2 and Cys15,Cys6 and Cys11." L "[Ref.28741926] CC50 = 67.0 5.0 M against CRL-1739, CC50 = 3.7 0.2 M against MM96L, CC50 = 49.9 16.6M against HFF-1, CC50 =54.15.0 M against HeLa, CC50 = 3.8 0.3 M against K-562." Not found 10942757##28741926 J Biol Chem. 2000 Oct 27;275(43):33464-33470.##ACS Chem Biol.?2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Silva PI Jr, Daffre S, Bulet P.##Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" "Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.##Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties" DRAMP03967 KWKLFKKIPKFLHLAKKF 18 P18 (Cecropin A(1-8)-Magainin 2(1?12) hybrid peptide analogue) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Alpha helix Not found None MOA: P18 kills cancer cells by disrupting membranes (Tang C et al 2010 Org Biomol Che 8:984-7). "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=1.56 ?M), Bacillus megaterium KCTC 1096 (MIC=0.78 ?M).##Tumor cells: MDA-MB-361 (IC50=8.0 ?M), Jurkat (IC50=4.0 ?M), K-562 (IC50=3.5 ?M), Normal cells NIH 3T3 (IC50=75.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12005420##12370027 J Pept Res. 2001 Dec;58(6):504-514.##Protein Pept Lett. 2002 Oct;9(5):395-402. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI.##Lee SH, Lee DG, Yang ST, Kim Y, Kim JI, Hahm KS, Shin SY." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs.##Antibiotic activity of reversed peptides of alpha-helical antimicrobial peptide, P18." DRAMP03968 KWKLFKKILKFLHLAKKF 18 [L9]-P18 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 ?M), Proteus vulgaris (MIC=6.25 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=3.0 ?M), Jurkat (IC50=9.0 ?M), K-562 (IC50=3.0 ?M), Normal cells NIH 3T3 (IC50=70.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03969 KWKLFKKISKFLHLAKKF 18 [S9]-P18 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=25.0 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=6.25 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=4.0 ?M), Jurkat (IC50=7.0 ?M), K-562 (IC50=3.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03970 WKLFKKIPKFLHLAKKF 17 N-1 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=9.5 ?M), Jurkat (IC50=12.0 ?M), K-562 (IC50=6.0 ?M), Normal cells NIH 3T3 (IC50=75.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03971 FKLFKKIPKFLHLAKKF 17 N-2 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=0.78 ?M).##Tumor cells: MDA-MB-361 (IC50=11.0 ?M), Jurkat (IC50=11.0 ?M), K-562 (IC50=7.0 ?M), Normal cells NIH 3T3 (IC50=70.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03972 KWFKKIPKFLHLAKKF 16 N-3 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=17.0 ?M), Jurkat (IC50=17.0 ?M), K-562 (IC50=11.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03973 WFKKIPKFLHLAKKF 15 N-4 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=32.0 ?M), Jurkat (IC50=23.0 ?M), K-562 (IC50=24.0 ?M), Normal cells NIH 3T3 (IC50=100.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03974 WKKIPKFLHLAKKF 14 N-5 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03975 KWFKKIPKFLHLLKKF 16 N-3L (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=3.125 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=1.56 ?M), Bacillus megaterium KCTC 1096 (MIC=0.78 ?M).##Tumor cells: MDA-MB-361 (IC50=5.0 ?M), Jurkat (IC50=4.0 ?M), K-562 (IC50=4.2 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03976 WFKKIPKFLHLLKKF 15 N-4L (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=3.125 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=1.56 ?M), Proteus vulgaris (MIC=12.5 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=0.78 ?M).##Tumor cells: MDA-MB-361 (IC50=5.0 ?M), Jurkat (IC50=6.0 ?M), K-562 (IC50=3.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03977 WKKIPKFLHLLKKF 14 N-5L (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=3.125 ?M), Proteus vulgaris (MIC=12.5 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=17.0 ?M), Jurkat (IC50=14.0 ?M), K-562 (IC50=10.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03978 KWKLFKKIPFLHLAKKF 17 C-1 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=26.0 ?M), Jurkat (IC50=32.0 ?M), K-562 (IC50=31.0 ?M), Normal cells NIH 3T3 (IC50=100.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03979 KWKLFKKIPKFLHLAKK 17 C-2 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=38.0 ?M), Jurkat (IC50=26.0 ?M), K-562 (IC50=23.0 ?M), Normal cells NIH 3T3 (IC50=100.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03980 KWKLFKKIPLHLAKKF 16 C-3 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25-12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78-1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=79.0 ?M), Jurkat (IC50=74.0 ?M), K-562 (IC50=62.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03981 KWKLFKKIPKFLHLAK 16 C-4 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=3.125-6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=3.125 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=54.0 ?M), Jurkat (IC50=31.0 ?M), K-562 (IC50=25.0 ?M), Normal cells NIH 3T3 (IC50=50.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03982 KWKLFKKIPHLAKKF 15 C-5 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=12.5 ?M), Proteus vulgaris (MIC=1.56 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=1.56 ?M).##Tumor cells: MDA-MB-361 (IC50=100.0 ?M), Jurkat (IC50=81.0 ?M), K-562 (IC50=67.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03983 KWKLFKKIPKFLHLA 15 C-6 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25-12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=47.0 ?M), Jurkat (IC50=21.0 ?M), K-562 (IC50=27.0 ?M), Normal cells NIH 3T3 (IC50=100.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03984 KWKLFKKIPLAKKF 14 C-7 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25-12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=12.5 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03985 KWKLFKKIPKFLHL 14 C-8 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M).##Tumor cells: MDA-MB-361 (IC50=83.0 ?M), Jurkat (IC50=54.0 ?M), K-562 (IC50=30.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03986 KWKLFKKIPLKKF 13 C-9 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=12.5 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=12.5 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=12.5 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP03987 KWKLFKKIPKFLH 13 C-10 (analog of P18) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25 ?M), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25-12.5 ?M), Proteus vulgaris (MIC=3.125 ?M).##Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=1.56 ?M), Staphylococcus aureus KCTC 1621 (MIC=6.25 ?M), Bacillus megaterium KCTC 1096 (MIC=3.125 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12005420 J Pept Res. 2001 Dec;58(6):504-514. "Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI." "Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs." DRAMP02459 ADDKNPLEECFRETDYEEFLEIARNGLKATSNPKRVV 37 "L-amino-acid oxidase (BjarLAAO-I; LAAO; LAO; snakes, reptils, animals)" P0DI88 Belongs to the flavin monoamine oxidase family (FIG1 subfamily) Not found Bothrops jararaca (Jararaca) "Antimicrobial, Antibacterial, Anti-Gram+, Antiparasitic, Antitumor" Protein level Not found Not found None "Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids (L-Met, L-Leu, L-Phe, L-Ile), thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, edema, apoptosis of vascular endothelial cells or tumor cell lines, as well as regulation of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions By similarity. This protein induce hemolysis and has antibacterial and antiparasitic activities (against the Gram-positive S.aureus). Tested in vivo, this protein significantly inhibits Ehrlich ascite tumors growth and induces an influx of polymorphonuclear cells, as well as spontaneous liberation of hydrogen peroxide from peritoneal macrophages. Tissue specificity: Expressed by the venom gland. Miscellaneous: Has parasiticidal activities against both trypanosomes and leishmania, as a result of enzyme-catalyzed hydrogen peroxide production." Gram-positive bacterium: S. aureus. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18346051##19101583##20615423 Basic Clin Pharmacol Toxicol. 2008 Jun;102(6):533-542.##Toxicon. 2009 Mar 1;53(3):330-341.##Toxicon. 2010 Nov;56(6):944-955. "de Vieira Santos MM, Sant'Ana CD, Giglio JR, da Silva RJ, Sampaio SV, Soares AM, Fecchio D.##Ciscotto P, Machado de Avila RA, Coelho EA, Oliveira J, Diniz CG, Faras LM, de Carvalho MA, Maria WS, Sanchez EF, Borges A, Chvez-Olrtegui C.##olindo P, Teixeira-Ferreira AS, DaMatta RA, Alves EW." "Antitumoural effect of an L-amino acid oxidase isolated from Bothrops jararaca snake venom.##Antigenic, microbicidal and antiparasitic properties of an L-amino acid oxidase isolated from Bothrops jararaca snake venom.##L-amino acid oxidase activity present in fractions of Bothrops jararaca venom is responsible for the Induction: of programmed cell death in Trypanosoma cruzi." DRAMP02465 ADDINPKEECFFEDDYYEFE 20 "L-amino-acid oxidase L1 (LAAO; LAAO-L1; LAO; Reptiles, animals)" P86535 Belongs to the flavin monoamine oxidase family (FIG1 subfamily) Not found Daboia russelii (Russel's viper) (Vipera russelii) "Antimicrobial, Antibacterial, Antitumor, Antiparasitic" Protein level Not found Not found None "Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions By similarity. Tissue specificity: Expressed by the venom gland. Biophysicochemical properties: Kinetic parameters (KM=0.297 mM for L-Met; KM=1.44 mM for L-Ile; KM=0.750 mM for L-Leu; KM=0.066 mM for L-Phe; KM=0.210 mM for L-Trp; KM=0.052 mM for L-Tyr; Vmax=8.96 ?mol/min/mg enzyme toward L-Phe)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18384385##20203422 FEBS J. 2008 May;275(9):2078-2095.##Biomed Res. 2010 Feb;31(1):71-81. "Mandal S, Bhattacharyya D.##Suzuki M, Itoh T, Anuruddhe BM, Bandaranayake IK, Shirani Ranasinghe JG, Athauda SB, Moriyama A." Two L-amino acid oxidase isoenzymes from Russell's viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs.##Molecular diversity in venom proteins of the Russell's viper (Daboia russellii russellii) and the Indian cobra (Naja naja) in Sri Lanka. DRAMP02466 ADDKNPLEECFCEDDDYCEG 20 "L-amino-acid oxidase L2 (LAAO; LAAO-L2; LAO; Reptiles, animals)" P0DI90 Belongs to the flavin monoamine oxidase family (FIG1 subfamily) Not found Daboia russelii (Russel's viper) (Vipera russelii) "Antimicrobial, Antibacterial, Antitumor, Antiparasitic" Protein level Not found Not found None "Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions By similarity. Tissue specificity: Expressed by the venom gland. Biophysicochemical properties: Kinetic parameters (KM=1.89 mM for L-Ile; KM=599.7 ?M for L-Leu; KM=222.8 ?M for L-Met; KM=49.3 ?M for L-Phe; KM=235.1 ?M for L-Trp; KM=538.2 ?M for L-Tyr; Vmax=6.94 ?mol/min/mg enzyme toward L-Phe)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18384385 FEBS J. 2008 May;275(9):2078-2095. "Mandal S, Bhattacharyya D." Two L-amino acid oxidase isoenzymes from Russell's viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs. DRAMP02467 ADDKNPLEECFREDDYEEFLEIAKNGLKKTSNPKHIVYPVKPSEQLYEESLRDQLPTSMHRYPSMIQKIFFAGEYTANAHGWIDSTIK 88 "L-amino-acid oxidase (LAAO; LAO; Reptiles, animals)" P0C2D7 Belongs to the flavin monoamine oxidase family (FIG1 subfamily) Not found Vipera berus berus (Common viper) "Antimicrobial, Antibacterial, Antitumor, Antiparasitic" Protein level Not found Not found None "Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids (the most specific substrate is L-Phe, followed by L-Met, L-Leu, L-Phe, L-Ile, L-Arg and L-His), thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities By similarity. In addition, this protein has an ability to induce apoptosis in cultured HeLa and K562 cells, and inhibits ADP-induced platelet aggregation dose-dependently. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions. Tissue specificity: Expressed by the venom gland. Biophysicochemical properties: Kinetic parameters (KM=0.361 mM for L-Leu; KM=0.286 mM for L-Met; KM=0.058 mM for L-Phe)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16574513 Biochim Biophys Acta. 2006 Apr;1764(4):707-714. "Samel M, Vija H, R?nnholm G, Siigur J, Kalkkinen N, Siigur E." Isolation and characterization of an apoptotic and platelet aggregation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom. DRAMP02488 ADDRNPLEEFRENNYEEFL 19 "L-amino-acid oxidase ACTX-8 (LAAO; LAO; Snakes, reptiles, animals)" P0DI85 Belongs to the flavin monoamine oxidase family (FIG1 subfamily) Not found Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) "Antimicrobial, Antibacterial, Antitumor, Antiparasitic" Protein level Not found Not found None "Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). Induces apoptosis in HeLa cervical cancer cells. Both the caspase-dependent and the mitochondrial pathways seem to be involved in apoptosis. Tissue specificity: Expressed by the venom gland." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17275856 Life Sci. 2007 Mar 6;80(13):1189-1197. "Zhang L, Wei LJ." "ACTX-8, a cytotoxic L-amino acid oxidase isolated from Agkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells." DRAMP03064 HGVSGHGQHGVHG 13 "Alloferon-1 (Insects, animals)" P83412 Not found Not found Calliphora vicina (Blue blowfly) (Calliphora erythrocephala) "Antimicrobial, Antiparasitic, Antiviral, Antitumor" Protein level Not found Not found None "Function: Antimicrobial peptide presumably with antiparasitic, antiviral and/or Antitumoral activities. Tissue specificity: Hemolymph. Induction: By bacterial infection. Miscellaneous: Stimulates antiviral and antitumoral resistance when injected in mice. Enhances natural cytotoxicity of blood and spleen lymphocytes. Induces interferon production in mouse and human." Human influenza viruses A and B. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12235362 Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32. "Chernysh S, Kim SI, Bekker G, Pleskach VA, Filatova NA, Anikin VB, Platonov VG, Bulet P." Antiviral and antitumor peptides from insects. DRAMP18114 DAINSPVTCCYTLTSKKISMQRLMSYRRVTSSKCPKEAVIFKTIAGKEICAEPKXXWVQDSISHLDKKNQXPKP 74 Monocyte chemotactic protein 1B (MCP-1B; Fragment) P80343 Belongs to the intercrine beta (chemokine CC) family Not found Bos taurus (Bovine) Antitumor Protein level Not found Not found None "Function: Chemotactic factor that attracts monocytes, but not neutrophilS. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin.##PTM: The N-terminus is blocked." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7947749 Biochemistry 33:13406-13412 (1994). "Proost P., Wuyts A., Lenaerts J.-P., van Damme J." "Purification, sequence analysis, and biological characterization of asecond bovine monocyte chemotactic protein-1 (Bo MCP-1B)." DRAMP18115 QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWV 60 C-C motif chemokine 7 (Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; "P80098, Q569J6" Belongs to the intercrine beta (chemokine CC) family CCL7 Homo sapiens (Human) Antitumor Protein level 14% helical (1 helices; 11 residues) "The shape of the MCP-3 monomer is that of an elongated tetrahedral. It consists of a three-stranded antiparallel ?? sheet and a three turn C-terminal ? helix lying above the sheet floor. The N-terminal extremity is disordered up to residue 12, but located close to the helix; it consists of a long mobile loop, spatially stabilized because of the two disulfide bonds which link Cys 11 with Cys 36 and Cys 12 with Cys 52." "1BO0, 1NCV resolved by NMR" "Function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophilS. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.##PTM: O-glycosylated." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8461011##7916328##8318676##15489334##1613466##15340161 BiocheM. BiophyS. ReS. Commun. 191:535-542 (1993).##Genomics 21:403-408 (1994).##Eur. Cytokine Netw. 4:99-110 (1993).##Genome ReS. 14:2121-2127 (2004).##J. Exp. Med. 176:59-65 (1992).##Protein Sci. 13:2819-282 "Opdenakker G., Froyen G., Fiten P., Proost P., van Damme J.##Opdenakker G., Fiten P., Nys G., Froyen G., van Roy N., Speleman F., Laureys G., van Damme J.##Minty A., Chalon P., Guillemot J.-C. , Kaghad M. , Liauzun P., Magazin M. , Miloux B., Minty C. , Ramond P., Vita N., Lupker J., Shire D., Ferrara P., Caput D.##The MGC Project Team##van Damme J., Proost P., Lenaerts J.-P., Opdenakker G.##Zhang Z., Henzel W.J.##Kim K.-S. , Rajarathnam " "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning ofthe cDNA and comparison with other chemokineS. ##The human MCP-3 gene (SCYA7): cloning, sequence analysis, andassignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.##Molecular cloning of the MCP-3 chemokine gene and regulation of its expression.##The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).##Structural and functional identification of two human, tumor-" DRAMP18132 ADPRNPLEECFRETD 15 L-amino-acid oxidase Bfon20 (LAAO; LAO) P0DMG9 Belongs to the flavin monoamine oxidase family Not found Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai) "Antimicrobial, Antitumor, Antibacterial, Antiparasitic" Protein level Not found Not found None "Function: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18760386 J. Proteomics 71:473-485 (2008). "Tashima A.K., Sanz L., Camargo A.C. , Serrano S. M. , Calvete J.J." Snake venomics of the Brazilian pitvipers Bothrops cotiara andBothrops fonsecai. Identification of taxonomy markerS. DRAMP01274 QDRPKFCYLPADPAECNAYMPRFYYDSASNKCKEFIYGGCRGNANNFKNRAECRHTCVAS 60 Kunitz-type serine protease inhibitor PIVL; I2G9B4 Belongs to the venom Kunitz-type family Not found Macrovipera lebetina transmediterranea (Blunt-nosed viper) (Viperalebetina transmediterranea) Antitumor Protein level Not found Not found None "Function: Serine protease inhibitor that inhibits trypsin. Exhibits an anti-tumor effect and displays integrin inhibitory activity without being cytotoxiC. Is able to dose-dependently inhibit the adhesion, migration and invasion of human glioblastoma U87 cellS. Also impairs the function of alphavbeta3 and to a lesser extent, the activity of alphavbeta6, alphavbeta5, alpha1beta1 and alpha5beta1 integrinS. ##Miscellaneous: Does not inhibit chymotrypsin (PubMed: 23262217).When intracerebroventricularly injected into mice, does not cause any toxic symptoms until a dose of 2 ug (PubMed: 23262217)." IC50=250 nM on fibrinogen and 300 nM on fibronectin of glioblastoma cell line U87 No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23262217 Matrix Biol. 32:52-62 (2013). "Morjen M. , Kallech-Ziri O., Bazaa A., Othman H., Mabrouk K., Zouari-Kessentini R., Sanz L., Calvete J.J., Srairi-Abid N., El Ayeb M. , Luis J., Marrakchi N." "PIVL, a new serine protease inhibitor from Macrovipera lebetinatransmediterranea venom, impairs motility of human glioblastomacellS. " DRAMP21000 GCRRLCYKQRCVTYCRGR 18 cGm (Derived from Gm) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 M), Escherichia coli CGSC 5167 (MIC=0.06 M), Klebsiella pneumoniae ATCC 700603 (MIC=4-8 M), Acinetobacter baumannii ATCC 19606 (MIC=1-2 M), Pseudomonas aeruginosa ATCC 27853 (MIC=1-4 M), Helicobacter pylori ATCC 43504 (MIC= M);##Fungi : Candida albicans ATCC 90028 (MIC=4-8 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 M)" "[Ref.28741926] 5% hemolysis at 0.03 M , 0% hemolysis at 1.1 M , 10% hemolysis at 17 M , 50% hemolysis at 100M against human red blood cells" Cyclic No specific N-terminal No specific C-terminal "Disulfide bond between Cys2 and Cys15,Cys6 and Cys11." L "[Ref.28741926] CC50 = 39.8 1.0 M against CRL-1739, CC50 = 2.9 0.1 M against MM96L, CC50 = 71.7 9.2 M against HFF-1, CC50 > 64 M against HeLa, CC50 = 15.3 1.4 M against MCF-7, CC50 = 2.7 0.1 M against K-562, CC50 = 12.7 1.1 M PBMCs." Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21001 GCRRLCWKQRCVTYCRGR 18 [Y7W]cGm (Derived from Gm) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic form Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria [Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1-2 M) [Ref.28741926] 35.1-55.5% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 = 23.3 0.4 M against CRL-1739, CC50 = 5.1 0.3 M against MM96L, CC50 = 39.7 3.8 M against HFF-1, CC50 > 64 M against HeLa, CC50 = 3.9 0.2 M against K-562. " Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21002 GCRRLCYKQRCVTWCRGR 18 [Y14W]cGm (Derived from Gm) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic form Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria [Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1-2 M) [Ref.28741926] 46.1-55.5% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 = 30.3 1.1 M against CRL-1739, CC50 = 4.0 0.1 M against MM96L, CC50 = 68.4 9.6 M against HFF-1, CC50 = 50.4 2.4 M against HeLa, CC50 = 2.7 0.1 M against K-562. " Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21003 GCRRLCYRQRCVTYCRGR 18 [K8R]cGm (Derived from Gm) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic form Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria [Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1-2 M) [Ref.28741926] 34.8-54.8% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 = 29.4 1.1 M against CRL-1739, CC50 = 5.0 0.3 M against MM96L, CC50 = 34.5 3.6 M against HFF-1, CC50 = 39.4 2.6 M against HeLa, CC50 = 3.1 0.1 M against K-562." Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21004 GCRRLCWRQRCVTWCRGR 18 "[Y7W, K8R, Y14W]cGm (Derived from Gm) " No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria [Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1 M) [Ref.28741926] 42-49.8% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 = 31.6 1.3 M against CRL-1739, CC50 = 5.4 0.3 M against MM96L, CC50 = 31.3 2.6 M against HFF-1, CC50 = 41.0 4.2 M against HeLa, CC50 = 15.1 1.4 M against MCF-7, CC50 = 3.9 0.1 M against K-562." Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21005 GCRALCYKQRCVTYCRGA 18 "[R4A, R18A]cGm (Derived from Gm) " No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=8 M), Escherichia coli CGSC 5167 (MIC=0.5-1 M), Klebsiella pneumoniae ATCC 700603 (MIC=32 M), Acinetobacter baumannii ATCC 19606 (MIC=8-16 M), Pseudomonas aeruginosa ATCC 27853 (MIC=8 M), Helicobacter pylori ATCC 43504 (MIC>80 M);##Fungi : Candida albicans ATCC 90028 (MIC=32 M), Cryptococcus neoformans ATCC 208821 (MIC=8-16 M)" "[Ref.28741926] 0% hemolysis at 17 M , 3% hemolysis at 35 M , 30-48.6% hemolysis at 64 M , 40% hemolysis at 100 M against human red blood cells" Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 > 64 M against CRL-1739, CC50 = 10.3 1.1 M against MM96L, CC50 = 51.2 4.0 M against HFF-1, CC50 > 64 M against HeLa, CC50 = 48.4 0.7 M against MCF-7, CC50 = 11.5 0.6 M against K-562, CC50 = 34.1 3.9 M against HL-60;CC50=30.8 2.5M against PBMCs." Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21006 KCRRLCYRQRCVTYCRGR 18 "[G1K, K8R]cGm (Derived from Gm) " No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=2 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=0.5-1 M), Escherichia coli CGSC 5167 (MIC<0.015 M), Klebsiella pneumoniae ATCC 700603 (MIC=8 M), Acinetobacter baumannii ATCC 19606 (MIC=1-2 M), Pseudomonas aeruginosa ATCC 27853 (MIC<0.25 M), Helicobacter pylori ATCC 43504 (MIC>80 M);##Fungi : Candida albicans ATCC 90028 (MIC=2 M), Cryptococcus neoformans ATCC 208821 (MIC=0.125-0.25 M)" "[Ref.28741926] 0% hemolysis at 0.5 M , 2.5% hemolysis at 0.6 M , 20% hemolysis at 8 M , 43.3-56.9% hemolysis at 64 M , 50% hemolysis at 100 M against human red blood cells" Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 = 19.5 0.5 M against CRL-1739, CC50 = 1.7 0.1 M against MM96L, CC50 = 9.0 0.5 M against HFF-1, CC50 = 44.2 2.2M against HeLa, CC50 = 6.7 0.7 M against MCF-7, CC50 = 2.1 0.2 M against K-562, CC50 = 9.0 1.1M against HL-60;CC50=5.1 0.3M against PBMCs." Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21007 GURRLUYKQRUVTYURGR 18 [C/U]cGm (Derived from Gm) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4-8 M), Escherichia coli CGSC 5167 (MIC=0.03-0.06 M), Klebsiella pneumoniae ATCC 700603 (MIC=8-16 M), Acinetobacter baumannii ATCC 19606 (MIC=4 M), Pseudomonas aeruginosa ATCC 27853 (MIC=2-4 M), Helicobacter pylori ATCC 43504 (MIC>80 M);##Fungi : Candida albicans ATCC 90028 (MIC=4-8 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 M)" [Ref.28741926] 32.3-33.3% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between SeCys2 and SeCys15, SeCys6 and SeCys11. The 'U' in sequence is SelenoCys." L "[Ref.28741926] CC50 = 51.0 4.6 M against CRL-1739, CC50 = 4.6 0.2 M against MM96L, CC50 = 15.6 3.6 M against HFF-1, CC50 > 64 M against HeLa, CC50 = 37.5 3.3 M against MCF-7, CC50 = 1.4 0.2 M against K-562, CC50 = 38.5 4.8 M against HL-60;CC50=15.5 0.8M against PBMCs." Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21008 GCRRWCYKQRCVTYCRGR 18 [L5W]cGm (Derived from Gm) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor" Synthetic form Not found Not found None Function: Antibacterial activity against Gram-positive bacteria [Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8-16 M) [Ref.28741926] 36.8-43.4% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 = 18.3 1.4 M against CRL-1739, CC50 = 4.0 0.1 M against MM96L, CC50 = 25.0 2.9 M against HFF-1, CC50 = 17.1 0.7 M against HeLa, CC50 = 1.0 0.1 M against K-562. " Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21009 GCRRLCYKQRCVTYCRGpPR 20 [D-P L-P]cGm (Derived from Gm) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 M), Klebsiella pneumoniae ATCC 700603 (MIC=1-4 M), Acinetobacter baumannii ATCC 19606 (MIC=1-4 M), Pseudomonas aeruginosa ATCC 27853 (MIC=4 M);##Fungi : Candida albicans ATCC 90028 (MIC=8 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 M)" [Ref.28741926] 41.5-44.9% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 = 22.5 3.3 M against CRL-1739, CC50 = 3.0 0.1 M against MM96L, CC50 = 14.9 0.8 M against HFF-1, CC50 = 51.5 3.9 M against HeLa, CC50 = 3.9 0.2 M against K-562, CC50 = 14.1 0.9 M against PBMCs" Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21010 KCRRYCYRQRCVTYCRGR 18 "[G1K, L5Y, K8R]cGm (Derived from Gm) " No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=0.5-1 M), Klebsiella pneumoniae ATCC 700603 (MIC=4-8 M), Acinetobacter baumannii ATCC 19606 (MIC=1-2 M), Pseudomonas aeruginosa ATCC 27853 (MIC<0.25-0.5 M);##Fungi : Candida albicans ATCC 90028 (MIC=4 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5 M)" [Ref.28741926] 20.6-32% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys2 and Cys15, Cys6 and Cys11." L "[Ref.28741926] CC50 = 26.5 2.4 M against CRL-1739, CC50 = 2.0 0.1 M against MM96L, CC50 = 14.7 1.5 M against HFF-1, CC50 = 20.9 1.4 M against HeLa, CC50 = 15.2 1.9 M against MCF-7, CC50 = 1.3 0.1 M against K-562, CC50 = 15.7 1.1M against HL-60;CC50=10.4 1.0M against PBMCs." Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21011 KURRYUYRQRUVTYURGR 18 "[C/U, G1K, L5Y, K8R]cGm (Derived from Gm)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria "[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1-2 M), Klebsiella pneumoniae ATCC 700603 (MIC=4-16 M), Acinetobacter baumannii ATCC 19606 (MIC=1-2 M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 M);##Fungi : Candida albicans ATCC 90028 (MIC=4 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 M)" [Ref.28741926] 17.8-24% hemolysis at 64 M against human red blood cells Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between SeCys2 and SeCys15, SeCys6 and SeCys11. The 'U' in sequence is SelenoCys." L "[Ref.28741926] CC50 = 46.2 7.6 M against CRL-1739, CC50 = 2.3 0.2 M against MM96L, CC50 = 30.8 2.0 M against HFF-1, CC50 = 36.2 2.8 M against HeLa, CC50 = 29.0 3.7 M against MCF-7, CC50 = 6.4 0.6 M against K-562, CC50 = 33.3 7.4M against HL-60;CC50=9.5 0.5M against PBMCs." Not found 28741926 ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties DRAMP21012 KILRGVCKKIMRTFLRRISKDILTGKK 27 "NK-2 (Mammals, Animals)" No entry found Not found Not found Mammal "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Not found Alpha helix Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.29043494]Gram-positive bacteria : Staphylococcus aureus (MIC=2 M), Staphylococcus epidermidis (MIC=2 M);##Gram-negative bacteria : Escherichia coli (MIC=4 M), Pseudomonas aeruginosa (MIC=8 M)" "[Ref.29043494] 2.5% hemolysis at 10 g/ml , 8% hemolysis at 25 g/ml , 22% hemolysis at 50 g/ml , 32.5% hemolysis at 75 g/ml , 36% hemolysis at 150 g/ml , 38% hemolysis at 300 g/ml against human red blood cells" Linear Free Amidation None L [Ref.29043494] IC50 = 25.1 M against NK-2. ##IC50 = 8.4 M against EJ. ##IC50 = 4.1 M against PC-3. ##IC50 = 10.1 M against T24. ##IC50 = 13.7 M against HL-60. ##The proliferation inhibition activity on K562 is not significant. Not found 29043494 Probiotics Antimicrob Proteins. 2018 Mar;10(1):118-127. doi: 10.1007/s12602-017-9335-1. Jiexi Yan & Xiaolei Liang & Chang Liu & Yuemei Cheng & Lanxia Zhou & Kairong Wang & Li Zhao Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2 DRAMP21013 KILRGVCKKIMRPFLRRISKDILTGKK 27 NK-pro (Derived from NK-2) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Alpha helix Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria "[Ref.29043494]Gram-positive bacteria : Staphylococcus aureus (MIC=4 M), Staphylococcus epidermidis (MIC=4 M);##Gram-negative bacteria : Escherichia coli (MIC=4 M), Pseudomonas aeruginosa (MIC=16 M)" "[Ref.29043494] 0.3% hemolysis at 10 g/ml , 2% hemolysis at 25 g/ml , 5.5% hemolysis at 50 g/ml , 8% hemolysis at 75 g/ml , 15% hemolysis at 150 g/ml , 28% hemolysis at 300 g/ml against human red blood cells" Linear Free Amidation None L [Ref.29043494] IC50 = 43.7 M against NK-2. ##IC50 = 23.3 M against EJ. ##IC50 = 9.3 M against PC-3. ##IC50 = 33.0 M against T24. ##IC50 = 26.1 M against HL-60. ####The proliferation inhibition activity on K562 is not significant. Not found 29043494 Probiotics Antimicrob Proteins. 2018 Mar;10(1):118-127. doi: 10.1007/s12602-017-9335-1. Jiexi Yan & Xiaolei Liang & Chang Liu & Yuemei Cheng & Lanxia Zhou & Kairong Wang & Li Zhao Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2 DRAMP21014 KILPGVCKKIMRPFLRRISKDILTGKK 27 NK-dpro (Derived from NK-2) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Synthetic form Alpha helix Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria "[Ref.29043494]Gram-positive bacteria : Staphylococcus aureus (MIC=8 M), Staphylococcus epidermidis (MIC=8 M);##Gram-negative bacteria : Escherichia coli (MIC=8 M), Pseudomonas aeruginosa (MIC=32 M)" "[Ref.29043494] 0% hemolysis at 10 g/ml , 2% hemolysis at 25 g/ml , 3% hemolysis at 50 g/ml , 4.5% hemolysis at 75 g/ml , 10% hemolysis at 150 g/ml , 20% hemolysis at 300 g/ml against human red blood cells" Linear Free Amidation None L [Ref.29043494] IC50 = 32.5 M against NK-2. ##IC50 = 28.7 M against EJ. ##IC50 = 9.6 M against PC-3. ##IC50 = 39.6 M against T24. ##IC50 = 48.4 M against HL-60. ##The proliferation inhibition activity on K562 is not significant. Not found 29043494 Probiotics Antimicrob Proteins. 2018 Mar;10(1):118-127. doi: 10.1007/s12602-017-9335-1. Jiexi Yan & Xiaolei Liang & Chang Liu & Yuemei Cheng & Lanxia Zhou & Kairong Wang & Li Zhao Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2 DRAMP29088 INWLKIAKKVKGML 14 MK58911 (a peptide analog from the mastoparan class of wasps) No entry found Not found N/A Galleria mellonella "Antimicrobial, Antifungal, Antitumor" Synthetic form Not found Not found None "Comment: MK58911 is not toxic in two mammalian cells (lung fibroblasts and glioblastoma cells) and in the G. mellonella model and demonstrates both in vitro and in vivo antifungal efficacy. Moreover, the peptide acted on the membrane of fungal cells and induced necrosis." "[Ref.31867293] Fungi: C. neoformans (MIC = 31.2 g/mL), C. gattii (MIC = 15.6 g/mL), P. brasiliensis (MIC = 7.8 g/mL), P. lutzii (MIC = 15.6 g/mL)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L "[Ref.31867293]MK58911 was not toxic in lung fibroblasts (MRC5) and glioblastoma cells (U87) at tested concentrations, and a high IC50 of >500 g/mL was observed in both mammalian cells." Fungal cell membrane 31867293 Front Cell Infect Microbiol. 2019 Dec 6;9:419. doi: 10.3389/fcimb.2019.00419. eCollection 2019. "Singulani JL, Galeane MC, Ramos MD, Gomes PC, Dos Santos CT, de Souza BM, Palma MS, Fusco Almeida AM, Mendes Giannini MJS. " "Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide "