DRAMP_ID Sequence Sequence_Length Name Swiss_Prot_Entry Family Gene Source Activity Protein_existence Structure Structure_Description PDB_ID Comments Target_Organism Hemolytic_activity Linear/Cyclic/Branched N-terminal_Modification C-terminal_Modification Other_Modifications Stereochemistry Cytotoxicity Binding_Traget Pubmed_ID Reference Author Title DRAMP00275 GSSFCDSKCKLRCSKAGLADRCLKYCGICCEECKCVPSGTYGNKHECPCYRDKKNSKGKSKCP 63 Snakin-1 (StSN1; Cys-rich; Plant defensin) Q948Z4 Not found SN1 Solanum tuberosum (potato) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None "Function: Has an antimicrobial activity. Causes a rapid aggregation of both Gram-positive and Gram-negative bacteria, but the antimicrobial activity is not correlated with the capacity to aggregate bacteria. Tissue specificity: Expressed in tubers, stems, axillary and young floral buds, sepals, petals, stamens and carpels, but not in roots, stolons, shoot apex meristem or young leaves. Induction: No responses to methyl jasmonate, ethylene, abscisic acid, salicylic acid, isonicotinic acid, indolacetic acid, gibberellic acid and infection with incompatible bacterial or compatible fungual pathogens. PTM: Six disulfide bonds may be present." "[Ref.9885189] Gram-positive bacteria: Listeria monocytogenes (MIC=10 ?g/mL), Listeria innocua (MIC=10 ?g/mL), Listeria ivanovii (MIC=10 ?g/mL), Clavibacter michiganensis (EC50=1 ?M), Ralstonia solanacearum (rfa-) (EC50=30 ?M), Rhizobium meliloti (EC50=8 ?M).##Fungi: Botrytis cinerea (EC50=2 ?M), Fusarium solani (EC50=3 ?M), Fusarium culmorum (EC50=2 ?M), Fusarium oxysporum f. sp. conglutinans (EC50=10 ?M), Fusarium oxysporum f. sp. lycopersici (EC50=20 ?M), Plectosphaerella cucumerina (EC50=10 ?M), Colletotrichum graminicola (EC50=10 ?M), Colletotrichum lagenarium (EC50=10 ?M), Bipolaris maydis (EC50=20 ?M), Aspergillus flavus (EC50=20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free [Ref.9885189] Six disulfide bonds may be present L No cytotoxicity information found Not found 11891250##9885189 Plant Physiol. 2002 Mar;128(3):951-961.##Mol Plant Microbe Interact. 1999 Jan;12(1):16-23. "Marta Berrocal-Lobo, Ana Segura, Manuel Moreno, Gemma Lpez, Francisco Garca-Olmedo, Antonio Molina##A Segura, M Moreno, F Madue?o, A Molina, F Garca-Olmedo" "Snakin-2, an antimicrobial peptide from potato whose gene is locally induced by wounding and responds to pathogen infection.##Snakin-1, a peptide from potato that is active against plant pathogens." DRAMP00384 GNEGGGHGGHGGYGGYHHHGGGGGGYGGYHGGGGS 35 Cc-GRP (Gly-rich; Plants) No entry found Not found Not found Coffea canephora "Antimicrobial, Antifungal" Not found Rich Not found None "Comment: The sequence displayed is only the N-terminal sequence of 7 kD peptide. The peptide was located in the cell wall, cell surface and nucleus of Fusarium oxysporum. " "Fungi: Candida albicans (MIC=90 ?g/ml), Candida tropicalis (MIC=180 ?g/ml), Colletotrichum lindemuthianum (MIC=90 ?g/ml), Fusarium oxysporium (MIC=90 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 23500079 Biochim Biophys Acta. 2013 Mar 15.[Epub ahead of print] "Zottich U, Da Cunha M, Carvalho AO, Dias GB, Casarin N, Vasconcelos IM, Gomes VM." An antifungal peptide from Coffea canephora seeds with sequence homology to glycine-rich proteins exerts membrane permeabilization and nuclear localization in fungi. DRAMP00416 KLCERSSGTWSGVCGNNNACKNQCIRLEGAQHGSCNYVFPAHKCICYFPC 50 Raphanus sativus Antifungal Protein 3 (Rs-AFP3; Plant defensin) "O24332, Q39313" Belongs to the DEFL family AFP3 Raphanus sativus (Radish) & Brassica napus (Rape) "Antimicrobial, Antifungal" Protein inferred from homology Bridge Not found None "Function: Possesses antifungal activity sensitive to inorganic cations (By similarity). PTM: Problely contains four disulfide bonds 3-50; 14-35; 20-44; 24-46." "Fungi: Alternaria brassicicola (MIC=2 ?g/ml), Botrytis cinerea (MIC=2 ?g/ml), Fusarium culmorum (MIC=2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "There are four disulfide bonds between Cys3 and Cys50, Cys14 and Cys35, Cys20 and Cys44, Cys24 and Cys51." L No cytotoxicity information found Not found 7780308##8422949 Plant Cell. 1995 May;7(5):573-588.##FEBS Lett. 1993 Feb 1;316(3):233-240. "Terras FR, Eggermont K, Kovaleva V, Raikhel NV, Osborn RW, Kester A, Rees SB, Torrekens S, Van Leuven F, Vanderleyden J, et al.##Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF." Small cysteine-rich antifungal proteins from radish: their role in host defense.##A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species. DRAMP00417 QKLCERSSGTWSGVCGNNNACKNQCINLEGARHGSCNYIFPYHRCICYFPC 51 Raphanus sativus Antifungal Protein 4 (Rs-AFP4; Plant defensin) O24331 Belongs to the DEFL family AFP4 Raphanus sativus (Radish) "Antimicrobial, Antifungal" Protein inferred from homology Bridge Not found None "PTM: Contains four disulfide bonds 4-51;15-36;21-45;25-47, and Pyrrolidone carboxylic acid at position 1." "Fungi: Alternaria brassicicola (MIC=5 ?g/ml), Botrytis cinerea (MIC=9 ?g/ml), Fusarium culmorum (MIC=11 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization of a N-terminal glutamine (Conversion to pyrrolidone carboxylic acid) Free "There are four disulfide bonds between Cys4 and Cys51, Cys15 and Cys36, Cys21 and Cys45, Cys25 and Cys47." L No cytotoxicity information found Not found 7780308 Plant Cell. 1995 May;7(5):573-588. "Terras FR, Eggermont K, Kovaleva V, Raikhel NV, Osborn RW, Kester A, Rees SB, Torrekens S, Van Leuven F, Vanderleyden J, et al." Small cysteine-rich antifungal proteins from radish: their role in host defense. DRAMP00422 QKLCERPSGTWSGVCGNNNACKNQCINLEKARHGSCNYVFPAHKCICYFPC 51 Defensin-like protein 1 (Sa-AFP1; Plant defensin) P30231 Belongs to the DEFL family Not found Sinapis alba (White mustard) (Brassica hirta) "Antimicrobial, Antifungal" Protein level Bridge Not found None Function: Possesses antifungal activity sensitive to inorganic cations. "Fungi: Alternaria brassicola (MIC=1.2 ?g/ml), Botrytis cinerea (MIC=1.8 ?g/ml), Fusarium culmorum (MIC=4 ?g/ml), Fusarium oxysporum f.sp.lycopersici (MIC=6 ?g/ml), Pyricularia oryzae (MIC=0.5 ?g/ml), Verticillium dahliae (MIC=1.5 ?g/ml).##NOTE: In synthetic low ionic strength fungal growth medium." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization of a N-terminal glutamine (Conversion to pyrrolidone carboxylic acid) Free "There are four disulfide bonds between Cys4 and Cys51, Cys15 and Cys36, Cys21 and Cys45, Cys25 and Cys47." L No cytotoxicity information found Not found 8422949##8836771 FEBS Lett. 1993 Feb 1;316(3):233-240.##Int J Pept Protein Res. 1996 Jun;47(6):437-446. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF.##Neumann GM, Condron R, Polya GM." A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species.##Purification and mass spectrometry-based sequencing of yellow mustard (Sinapis alba L.) 6 kDa proteins. Identification as antifungal proteins. DRAMP00423 QKLCQRPSGTWSGVCGNNNACRNQCINLEKARHGSCNYVFPAHKCICYFPC 50 Defensin-like protein 2 (Sa-AFP2; Plant defensin) P30232 Not found Not found Sinapis alba (White mustard) (Brassica hirta) "Antimicrobial, Antifungal" Not found Not found Not found None Function: Possesses antifungal activity sensitive to inorganic cations. "Fungi: Alternaria brassicola (MIC=4.5 ?g/ml), Botrytis cinerea (MIC=3.5 ?g/ml), Fusarium culmorum (MIC=2.3 ?g/ml), Fusarium oxysporum f.sp.lycopersici (MIC=2.3 ?g/ml), Pyricularia oryzae (MIC=0.3 ?g/ml), Verticillium dahliae (MIC=1.2 ?g/ml).##NOTE: In synthetic low ionic strength fungal growth medium." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization of a N-terminal glutamine (Conversion to pyrrolidone carboxylic acid) Free "There are four disulfide bonds between Cys4 and Cys51, Cys15 and Cys36, Cys21 and Cys45, Cys25 and Cys47. The residue at position 8 is phosphorylated." L No cytotoxicity information found Not found 8422949 FEBS Lett. 1993 Feb 1;316(3):233-240. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF." A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species. DRAMP00425 LMCTHPLDCSN 11 Tn-AFP1 (Trapa natans antifungal peptide; Plant defensin) No entry found Not found Not found Trapa natans "Antimicrobial, Antifungal" Not found Not found Not found None Function: Tn-AFP1 has no adverse effect on red blood cells at concentration of 32 g/mL. Yeast: Candida tropicalis (MIC=32 ?g/ml). Tn-AFP1 has no adverse effect on red blood cells at concentration of 32 g mL?1 Cyclic Free Free There is a disulfide bond between Cys3 and Cys9 L No cytotoxicity information found Not found 21736910 Peptides. 2011 Aug;32(8):1741-1747. "Mandal SM, Migliolo L, Franco OL, Ghosh AK." Identification of an antifungal peptide from Trapa natans fruits with inhibitory effects on Candida tropicalis biofilm formation. DRAMP00436 KTCEHLADTYRGVCFTNASCDDHCKNKAHLISGTCHNWKCFCTQNC 46 Pisum sativum defensin 1 (Psd1; Plant defensin) P81929 Belongs to the DEFL family Not found Pisum sativum (Garden pea) "Antimicrobial, Antifungal" Protein level Combine helix and strand structure The protein has a globular fold with a triple-stranded antiparalell beta-sheet and an alpha-helix (from residue Asn17 to Leu27). 1JKZ resolved by NMR. PTM: Contains four disulfide bonds 3-46; 14-35; 20-40; 24-42. "PD: Aspergillus niger (MIC=12.1 ?g/ml), Aspergillus versicolor (MIC<5.0 ?g/ml), Fusarium moniliforme (MIC=21.7 ?g/ml), Fusarium oxysporum (MIC>100 ?g/ml), Fusarium solani (MIC=12.1 ?g/ml), Neurospora crassa (MIC=0.04 ?g/ml), Saccharomyces cerevisae (MIC>100 ?g/ml), Trichophyton mentagrophytes (MIC>100 ?g/ml).##PD+: Aspergillus niger (MIC=7.4 ?g/ml), Fusarium moniliforme (MIC=33.2 ?g/ml), Fusarium oxysporum (MIC=100 ?g/ml), Fusarium solani (MIC=79.2 ?g/ml), Neurospora crassa (MIC=0.05 ?g/ml).##NOTE: PD+: potato dextrose medium supplemented with 1 mM CaCl2." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) "There are four disulfide bonds between Cys3 and Cys46, Cys14 and Cys35, Cys20 and Cys40, Cys24 and Cys42" L No cytotoxicity information found It interacts with cell-cycle-realted protein cyclin F as the target. 10860545##11697857##11812144 Arch Biochem Biophys. 2000 Jun 15;378(2):278-286.##Arch Biochem Biophys. 2001 Nov 15;395(2):199-207.##J Mol Biol. 2002 Jan 25;315(4):749-757. "Almeida M.S, Cabral K.M, Zingali R.B, Kurtenbach E.##Almeida MS, Cabral KS, de Medeiros LN, Valente AP, Almeida FC, Kurtenbach E.##Almeida MS, Cabral KM, Kurtenbach E, Almeida FC, Valente AP." "Characterization of two novel defense peptides from pea (Pisum sativum) seeds.##cDNA cloning and heterologous expression of functional cysteine-rich antifungal protein Psd1 in the yeast Pichia pastoris.##Solution structure of Pisum sativum defensin 1 by high resolution NMR: plant defensins, identical backbone with different mechanisms of action." DRAMP00437 KTCENLSGTFKGPCIPDGNCNKHCRNNEHLLSGRCRDDFRCWCTNRC 47 Pisum sativum defensin 2 (Psd2; Plant defensin) P81930 Belongs to the DEFL family Not found Pisum sativum (Garden pea) "Antimicrobial, Antifungal" Protein level Bridge Not found None PTM: Contains four disulfide bonds 3-47; 14-35; 20-41; 24-43. "PD: Aspergillus niger (MIC=10.2 ?g/ml), Aspergillus versicolor (MIC=0.34 ?g/ml), Fusarium moniliforme (MIC=10.0 ?g/ml), Fusarium oxysporum (MIC>100 ?g/ml), Fusarium solani (MIC=8.5 ?g/ml), Neurospora crassa (MIC<0.5 ?g/ml), Saccharomyces cerevisae (MIC>100 ?g/ml), Trichophyton mentagrophytes (MIC<100 ?g/ml).##PD+: Aspergillus niger (MIC=7.8 ?g/ml), Aspergillus versicolor (MIC=5.9 ?g/ml), Fusarium moniliforme (MIC=25 ?g/ml), Fusarium oxysporum (MIC>100 ?g/ml), Fusarium solani (MIC=5.0 ?g/ml).##NOTE: PD+ = potato dextrose medium supplemented with 1 mM CaCl2." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) "There are four disulfide bonds between Cys3 and Cys47, Cys14 and Cys35, Cys20 and Cys41, Cys24 and Cys43." L No cytotoxicity information found Not found 10860545 Arch Biochem Biophys. 2000 Jun 15;378(2):278-286. "Almeida M.S, Cabral K.M, Zingali R.B, Kurtenbach E." Characterization of two novel defense peptides from pea (Pisum sativum) seeds. DRAMP00450 QKLCQRPSGTWSGVCGNNNACRNQCINLEKARHGSCNYVFPAHKCICYFPC 51 Defensin-like protein 2A (AFP2A; M2A; Plant defensin) P30232 Belongs to the DEFL family Not found Sinapis alba (White mustard) (Brassica hirta) "Antimicrobial, Antifungal" Protein level Rich Not found None "Function: Possesses antifungal activity sensitive to inorganic cations. Subunit structure: Forms oligomers in its native state. PTM: Contains four disulfide bonds (By similarity)." "Fungi: Alternaria brassicola (MIC=4.5 ?g/ml), Botrytis cinerea (MIC=3.5 ?g/ml), Fusarium culmorum (MIC=2.3 ?g/ml), Fusarium oxysporum f.sp. lycopersici (MIC=2.3 ?g/ml), Pyricularia oryzae (MIC=0.3 ?g/ml), Verticillium dahliae (MIC=1.2 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic [Ref.8422949] Cyclization of a N-terminal glutamine (Conversion to pyrrolidone carboxylic acid) Cyclization of a C-terminal Cys residue (forming a disulfide bond) "There are four disulfide bonds between Cys4 and Cys51, Cys15 and Cys36, Cys21 and Cys45, Cys25 and Cys47. [Ref.8836771] The residue at position 8 is phosphorylated." L No cytotoxicity information found Not found 8422949##8836771 FEBS Lett. 1993 Feb 1;316(3):233-240.##Int J Pept Protein Res. 1996 Jun;47(6):437-446. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF.##Neumann GM, Condron R, Polya GM." A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species.##Purification and mass spectrometry-based sequencing of yellow mustard (Sinapis alba L.) 6 kDa proteins. Identification as antifungal proteins. DRAMP00454 ATCKAECPTWDSVCINKKPCVACCKKAKFSDGHCSKILRRCLCTKEC 47 Petunia hybrida defensin 1 (PhD1; Cys-rich; Plant defensin) Q8H6Q1 Belongs to the DEFL family D1 Petunia hybrida (Petunia) "Antimicrobial, Antifungal" Protein level Combine helix and strand structure "PhD1 has the fold of the cysteine-stabilized alphabeta motif, consisting of an alpha-helix and a triple-stranded antiparallel beta-sheet, except that it contains a fifth disulfide bond from the first loop to the alpha-helix." 1N4N resolved by NMR. "Function: Plant defense peptide with antifungal activity. Tissue specificity: Petals. Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Biophysicochemical properties: pH dependence (Stable under extremes of pH); Temperature dependence (Stable under extremes of temperature). PTM: Contains five disulfide bonds 3-47; 7-23; 14-34; 20-41; 24-43." "Fungi: Fusarium oxysporum (MIC=10 ?g/ml), Botrytis cinerea (MIC=10 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "When compared to other plant defensins, the petunia defensins have an additional fifth disulfide bond. There are five disulfide bonds between Cys3 and Cys47, Cys7 and Cys23, Cys14 and Cys34, Cys20 and Cys41, Cys24 and Cys43." L No cytotoxicity information found Not found 12644678##12846570 Plant Physiol. 2003 Mar;131(3):1283-1293.##Biochemistry. 2003 Jul 15;42(27):8214-8222. "Lay FT, Brugliera F, Anderson MA.##Janssen BJ, Schirra HJ, Lay FT, Anderson MA, Craik DJ." "Isolation and properties of floral defensins from ornamental tobacco and petunia.##Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds." DRAMP00764 KSLRPRCWIKIKFRCKSLKF 20 Piceain 1 (Plants) No entry found Not found Not found Picea sitchensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Beta strand (CD) Not found None "Function: Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells. PTM: Contains one disulfide bond." "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 ?g/ml), S. aureus ATCC 43300 (MIC=9.38 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=18.75 ?g/ml), Escherichia coli ML-35P (MIC=18.75 ?g/ml), Escherichia coli 08040722 (CI) (MIC=75 ?g/ml), Escherichia coli 08A866 (CI) (MIC=37.5 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 ?g/ml).##Yeast: Candida albicans ATCC 20032 (MIC=9.38 ?g/ml)." "[Ref.21644248] At the concentration of 0.0625 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.7% & 1.5%; At the concentration of 0.125 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 7.2%; At the concentration of 0.25 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.9%&7.8%; At the concentration of 0.5 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.6% & 9.5%; At the concentration of 1 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 7.8% & 57.1%." Cyclic Free Free There is one intra-molecular disulfide bridge formed by Cys7 and Cys15. L No cytotoxicity information found Not found 21644248 J Pept Sci. 2011 Sep;17(9):627-631. "Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R." Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis. DRAMP00765 RPRCWIKIKFRCKSLKF 17 Piceain 2 (Plants) No entry found Not found Not found Picea sitchensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells. PTM: Contains one disulfide bond." "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 ?g/ml), S. aureus ATCC 43300 (MIC=18.75 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=37.5 ?g/ml), Escherichia coli ML-35P (MIC=37.5 ?g/ml), Escherichia coli 08040722 (CI) (MIC=75 ?g/ml), Escherichia coli 08A866 (CI) (MIC=37.5 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=18.75 ?g/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 ?g/ml).##Yeast: Candida albicans ATCC 20032 (MIC=18.75 ?g/ml)." "[Ref.21644248] At the concentration of 0.0625 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.6% & 2.2%; At the concentration of 0.125 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 0.8% & 4.7%; At the concentration of 0.25 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.2%&5.2%; At the concentration of 0.5 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 5.3% & 12.4%; At the concentration of 1 mg/ml, Piceain 1 induced human & rabbit red cell hemolysis of 11.3% & 66.3%." Cyclic Free Free There is one intra-molecular disulfide bridge formed by Cys4 and Cys12. L No cytotoxicity information found Not found 21644248 J Pept Sci. 2011 Sep;17(9):627-631. "Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R." Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis. DRAMP00856 GLPVCGETCVGGTCNTPGCTCSWPVCTRN 29 Kalata-B1 (Plant defensin) P56254 Belongs to the cyclotide family OAK1 Oldenlandia affinis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Beta strand (3 strands; 7 residues) Not found 2KHB resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans. Active against the Gram-positive S. aureus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. Inhibitory effect on the growth and development of larvae from H. punctigera. The unmodified form has hemolytic activity, the oxidized form lacks hemolytic activity. If the protein is linearized, hemolytic activity is lost. MOA: a small number of cyclotides bind to the membrane surface and then insert first into the outer membrane leaflet followed by penetration through the membrane and pore formation. At higher concentrations of cyclotides, destabilization of membranes occurs. Tissue specificity: Leaves and stems. Lower in roots. Pharmaceutical use: The uteroactive properties of Kalata have been discovered by African traditional medicine. It is used as an ingredient of a herbal tea to accelerate childbirth. PTM: Kalata-B1 is a cyclic peptide which contains three disulfide bonds 5-19; 11-21; 14-26." "[Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.26 ?M), Micrococcus luteus (MIC=40.4 ?M);##Gram-negative bacterium: Klebsiella oxytoca (MIC=54.8 ?M);##Fungi: Candida kefyr (MIC=21.4 ?M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=140 nM)." [Ref.12779323] HD50 = 300 M against Human type A red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.7703226] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys26." L [Ref.18008336]CEM-SS cells:IC50=3500 nM. Cell membrance 18008336##10430870##7703226##17534989##23129773 Biopolymers. 2008;90(1):51-60.##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biochemistry. 1995 Apr 4;34(13):4147-4158.##Chembiochem. 2007 Jun 18;8(9):1001-1011.##J Biol Chem. 2012 Dec 21;287(52):43884-98. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, G?ransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ." "Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions." DRAMP00877 GIPCGESCVWIPCISAALGCSCKNKVCYRN 30 Circulin-A (CIRA; Plant defensin) P56871 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Alpha helix (1 helices; 4 residues) "The molecule is stabilised by three disulfide bonds, two of which form an embedded loop completed by the backbone fragments connecting the cysteine residues. A third disulfide bond threads through the centre of this loop to form a ""cystine-knot"" motif. This motif is present in a range of other biologically active proteins, including omega-contoxin GVIA and Cucurbita maxima trypsin inhibitor." 1BH4 resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. PTM: This is a cyclic peptide which contains three disulfide bonds 1-17; 5-19; 10-24." [Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.19 ?M).##Gram-negative bacterium: Proteus vulgaris (MIC=54.6 ?M).##Fungi: Candida kefyr (MIC=18.6 ?M) and Candida tropicalis (MIC=19.4 ?M).##NOTE: Medium with 10 mM phosphate buffer.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM). [Ref.10430870] EC50 = 1020 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.8920961] There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27" L [Ref.18008336]CEM-SS cells:IC50=500 nM. Not found 18008336##10430870##9878410##8920961 Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. ##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J. Mol. Biol. 1999; 285:333-345. ##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##Tam JP, Lu YA, Yang JL, Chiu KW.##Daly NL, Koltay A, Gustafson KR, Boyd MR, Casas-Finet JR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell" "Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides" DRAMP00878 GVIPCGESCVFIPCISTLLGCSCKNKVCYRN 31 Circulin-B (CIRB; Plant defensin) P56879 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Beta strand (5 strands; 10 residues) Cyclotides are mini-proteins derived from plants that have the characteristic features of a head-to-tail cyclised peptide backbone and a knotted arrangement of their three disulfide bonds. 2ERI resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria. PTM: This is a cyclic peptide which contains three disulfide bonds 5-21; 9-23; 14-28." "[Ref.10430870]Gram-positive bacterium: (L-salt): Staphylococcus aureus (MIC=13.5 ?M).##Gram-negative bacteria: (L-salt, H-salt) (MIC ?M): Escherichia coli (0.41, >500), Pseudomonas aeruginosa (25.5, 48), Proteus vulgaris (6.8, >500), Klebsiella oxytoca (8.2, 15.6).##Fungi (H-salt): Candida kefyr (MIC=29 ?M).##NOTE: L-salt = Medium with 10 mM phosphate buffer; H-salt = L-salt supplemented with 100 mM NaCl.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM)." [Ref.10430870] EC50 = 550 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.8920961] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys27." L [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 820 M.##[Ref.18008336]CEM-SS cells:IC50=500 nM. Not found 10430870##18008336##8920961 Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biopolymers. 2008;90(1):51-60.##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. doi: 10.1006/bbrc.1996.1708. "Tam JP, Lu YA, Yang JL, Chiu KW.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell" "An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclotides as natural anti-HIV agents.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides" DRAMP01374 GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC 33 "Odorranain-D1 (OdD1; Frogs, amphibians, animals)" A6MBK7 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-D1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=16.32 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8.16 g/ml), Bacillus subtilis (MIC=8.16 g/ml).##Yeast: Candida albicans (MIC=4.08 g/ml)." [Ref:17272268]Non-hemolytic activity against rabbit red blood cells Cyclic Free Cyclization(Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.17272268]No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01373 GVLGAVKDLLIGAGKSAAQSVLKTLSCKLSNDC 33 "Odorranain-C1 (OdC1; Frogs, amphibians, animals)" A6MBF6 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-C1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=8.21 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.11 g/ml), Bacillus subtilis (MIC=16.42 g/ml).##Yeast: Candida albicans (MIC=2.05 g/ml)." [Ref:17272268] No detectable hemolytic activity against rabbit red blood cells. Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) [Ref:17272268] There are one disulfide bond between Cys27 and Cys33 L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01372 AALKGCWTKSIPPKPCFGKR 20 "Odorranain-B1 (OdB1; Frogs, amphibians, animals)" E7EKD9 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana hainanensis (Odor frog) (Rana hainanensis) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Homology Not found Odorranain-B1 adopts 5.9 % None "Function: Odorranain-B1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. Tissue specificity: Expressed by the skin glands." "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.21 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=5.83 g/ml), Bacillus subtilis (MIC=1.85 g/ml).##Yeast: Candida albicans (MIC=2.4 g/ml)." [Ref:17272268] No detectable hemolytic activity against rabbit red blood cells. Cyclic Free Free [Ref:17272268] There are one disulfide bond between Cys6 and Cys16 L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP00933 SAFTVWSGPGCNNRAERYSKCGCSAIHQKGGYDFSYTGQTAALYNQAGCSGVAHTRFGSSARACNPFGWKSIFIQC 76 Antimicrobial peptide 1 (AMP1; MiAMP1; Plant defensin) P80915 Not found Not found Macadamia integrifolia (Macadamia nut) "Antimicrobial, Antibacterial, Antifungal" Protein level Combine helix and strand structure MiAMP1 is made up of eight beta-strands which are arranged in two Greek key motifs. These Greek key motifs associate to form a Greek key beta-barrel. This structure is unique amongst plant antimicrobial proteins and forms a new class which we term the beta-barrelins. (Ref.2) 1C01 resolved by NMR. "Function: Antimicrobial peptide which inhibits the growth of a variety of fungi, oomycetes, Gram-positive bacterial phytopatogenes and S.cerevisiae in vitro. No activity against E.coli. Miscellaneous: Its antimicrobial activity is diminished by calcium an" "Alternaria helianthi (MIC=2-5 ?g/ml), Botrytis cinerea (MIC=5-10 ?g/ml), Ceratocystis parodoxa (MIC=20 ?g/ml), Colletotrichum gloeosporioides (MIC=2-5 ?g/ml), Fusurium oxysporum (MIC=2-5 ?g/ml), Leptosphaeria maculans (MIC=5 ?g/ml), Macrophomina phaseolina (MIC<25 ?g/ml), Phytophthoru cryptogea (MIC=5-10 ?g/ml), Pythium graminicola (MIC=5 ?g/ml), Sclerotinia sclerotiorum spores (MIC=5 ?g/ml), Sclerotinia sclerotiorum mycelia (MIC=50 ?g/ml), Verticilium dahliae (MIC=2 ?g/ml), Clavibacter michiganensis (MIC<10 ?g/ml), Saccharomyces cerevisiae (MIC=2-5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) "[Ref.10543955] There are three disulfide bonds between Cys11 and Cys64, Cys21 and Cys76, Cys23 and Cys49" L No cytotoxicity information found Not found 9108242##10543955 Eur J Biochem. 1997 Mar 15;244(3):743-749.##J Mol Biol. 1999 Oct 29;293(3):629-638. "Marcus JP, Goulter KC, Green JL, Harrison SJ, Manners JM.##McManus AM, Nielsen KJ, Marcus JP, Harrison SJ, Green JL, Manners JM, Craik DJ." "Purification, characterisation and cDNA cloning of an antimicrobial peptide from Macadamia integrifolia.##MiAMP1, a novel protein from Macadamia integrifolia adopts a Greek key beta-barrel fold unique amongst plant antimicrobial proteins." DRAMP01004 PQRGEGGRAGNLLREEQEI 19 Cucurmoschin (Plants) P84158 Not found Not found Cucurbita maxima (winter squash) "Antimicrobial, Antifungal" Protein level Not found Not found None Function: Has antifungal activity. Inhibits cell-free translation in rabbit reticulocyte lysate system. "Fungi: Botrytis cinerea (MIC=375 ?M), Fusarium oxysporum (MIC=375 ?M), Mycosphaerella arachidicola (MIC=375 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found Not found 14499274 Peptides. 2003 Jul;24(7):969-972. "Wang HX, Ng TB." "Isolation of cucurmoschin, a novel antifungal peptide abundant in arginine, glutamate and glycine residues from black pumpkin seeds." DRAMP01016 QCIGNGGRCNENVGPPYCCSGFCLRQPGQGYGYCKNR 37 Antimicrobial peptide 1 (MJ-AMP1; Plant defensin) P25403 Belongs to the AMP family AMP1 Mirabilis jalapa (Garden four-o'clock) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Bridge Not found None "Function: Possesses antifungal activity and is also active on two tested Gram-positive bacteria: but is non-toxic for Gram-negative bacteria and cultured human cells. Tissue specificity: Found only in seeds. PTM: Contains three disulfide bonds 2-19; 9-23;" "Fungi: Alternaria brassicola (MIC=20 ?g/ml), Ascochyta pisi (MIC=200 ?g/ml), Botrytis cinerea (MIC=50 ?g/ml), Cercospora beticola (MIC=10 ?g/ml), Colletotrichum lindemuthianum (MIC=6 ?g/ml), Fusarium culmorum (MIC=30 ?g/ml), Fusarium oxysporum f.sp.pisi (MIC=15 ?g/ml), Fusarium oxysporum f.sp.lycopersici (MIC=200 ?g/ml), Nectria haematococca (MIC=15 ?g/ml), Phoma betae (MIC=25 ?g/ml), Pyrenophora tritici-repentis (MIC=300 ?g/ml), Pyricularia oryzae (MIC=6 ?g/ml), Rhizoctonia solani (MIC=60 ?g/ml), Verticillium dahliae (MIC=12 ?g/ml), Venturia inequalis (MIC=12 ?g/ml).##Gram-positive bacteria: Bacillus megaterium (MIC=6 ?g/ml), Sarcina lutea (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Pyroglutamyl modification (Cyclization of a N-terminal glutamine) Free "There are three disulfide bonds between Cys2 and Cys19, Cys9 and Cys23, Cys18 and Cys34." L No cytotoxicity information found Not found 1733929##7647302 J. Biol. Chem. 1992;267:2228-2233.##Plant Mol. Biol. 1995;28:713-721. "Cammue B.P.A, de Bolle M.F.C, Terras F.R.G, Proost P, van Damme J, Rees S.B, Vanderleyden J, Broekaert W.F.##de Bolle M.F, Eggermont K, Duncan R.E, Osborn R.W, Terras F.R.G, Broekaert W.F." Isolation and characterization of a novel class of plant antimicrobial peptides from Mirabilis jalapa L. seeds.##Cloning and characterization of two cDNA clones encoding seed-specific antimicrobial peptides from Mirabilis jalapa L. DRAMP01017 CIGNGGRCNENVGPPYCCSGFCLRQPNQGYGVCRNR 36 Antimicrobial peptide 2 (MJ-AMP2; Plant defensin) P25404 Belongs to the AMP family AMP2 Mirabilis jalapa (Garden four-o'clock) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Bridge Not found None Function: Possesses antifungal activity and is also active on two tested Gram-positive bacteria: but is non-toxic for Gram-negative bacteria and cultured human cells. Tissue specificity: Found only in seeds. PTM: Contains three disulfide bonds 1-18; 8-22; "Fungi: Alternaria brassicola (MIC=6 ?g/ml), Ascochyta pisi (MIC=6 ?g/ml), Botrytis cinerea (MIC=2 ?g/ml), Cercospora beticola (MIC=2 ?g/ml), Colletotrichum lindemuthianum (MIC=1 ?g/ml), Fusarium culmorum (MIC=3 ?g/ml), Fusarium oxysporum f.sp.pisi (MIC=5 ?g/ml), Fusarium oxysporum f.sp.lycopersici (MIC=10 ?g/ml), Nectria haematococca (MIC=0.5 ?g/ml), Phoma betae (MIC=6 ?g/ml), Pyrenophora tritici-repentis (MIC=20 ?g/ml), Pyricularia oryzae (MIC=0.5 ?g/ml), Rhizoctonia solani (MIC=15 ?g/ml), Verticillium dahliae (MIC=0.5 ?g/ml), Venturia inequalis (MIC=1 ?g/ml).##Gram-positive bacteria: Bacillus megaterium (MIC=2 ?g/ml), Sarcina lutea (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization of a N-terminal Cys residue (forming a disulfide bond) Free "There are three disulfide bonds between Cys1 and Cys18, Cys8 and Cys22, Cys17 and Cys33." L No cytotoxicity information found Not found 1733929##7647302 J Biol Chem. 1992 Feb 5;267(4):2228-2233.##Plant Mol Biol. 1995 Jul;28(4):713-721. "Cammue BP, De Bolle MF, Terras FR, Proost P, Van Damme J, Rees SB, Vanderleyden J, Broekaert WF.##De Bolle MF, Eggermont K, Duncan RE, Osborn RW, Terras FR, Broekaert WF." Isolation and characterization of a novel class of plant antimicrobial peptides form Mirabilis jalapa L. seeds.##Cloning and characterization of two cDNA clones encoding seed-specific antimicrobial peptides from Mirabilis jalapa L. DRAMP01018 SIPCGESCVFIPCTVTALLGCSCKSKVCYKN 31 Cyclopsychotride-A (CPT; Plant defensin) P56872 Not found Not found Psychotria longipes "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-21; 8-23; 13-28." "Gram-negative bacteria: Escherichia coli (MIC=1.55 ?M), Pseudomonas aeruginosa (MIC=13.5 ?M), Proteus vulgaris (MIC=13.2 ?M), Klebsiella oxytoca (MIC=5.80 ?M).##Gram-positive bacteria: Staphylococcus aureus (MIC=39.0 ?M), Micrococcus luteus (MIC=48.0 ?M).##Fungi: Candida albicans (MIC>500 ?M), Candida kefyr (MIC=14.0 ?M), Candida tropicalis (MIC=56.5 ?M).##NOTE: Medium with 10 mM phosphate buffer." [Ref.10430870] HD50 = 405 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "There are three disulfide bonds between Cys4 and Cys21, Cys8 and Cys23, Cys13 and Cys28" L [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 1850 M. Not found 10430870##7714530 Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J Nat Prod. 1994 Dec;57(12):1619-1625. "Tam JP, Lu YA, Yang JL, Chiu KW.##Witherup KM, Bogusky MJ, Anderson PS, Ramjit H, Ransom RW, Wood T, Sardana M. " "An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes." DRAMP01061 SRSELIVHQR 10 Antifungal peptide (Cm-p1; Plants) B3EWI7 Not found Not found Cenchritis muricatus (Beaded periwinkle) "Antimicrobial, Antifungal" Protein level Not found Not found 2MP9 resolved by NMR. Function: The synthetic peptide has antifungal activity. Has no antibacterial or cytotoxic activity. "Fungi: Botrytis cinerea (MIC=20 ?M), Fusarium oxysporum (MIC=20 ?M), Aspergillus niger (MIC=41 ?M), Candida albicans 01U (MIC=13 ?M), C. albicans 38U (MIC=7 ?M), C. parapsilosis (MIC=105 ?M), C. neoformans strain L26 (MIC=209 ?M), C. neoformans strain L30 (MIC=209 ?M), Trichophyton rubrum (MIC=3 ?M)." "[Ref.22210491] At the highest evaluated dose (256 g/mL), Cm-p1 showed no signs of toxicity against human red blood cells." Linear Free Free (very possibly) None L "[Ref.22210491] At the highest evaluated dose (256 g/mL), Cm-p1 showed no signs of toxicity against RAW 264.7 cells." Not found 22210491 Biochimie. 2012 Apr;94(4):968-974. "Lpez-Abarrategui C, Alba A, Silva ON, Reyes-Acosta O, Vasconcelos IM, Oliveira JT, Migliolo L, Costa MP, Costa CR, Silva MR, Garay HE, Dias SC, Franco OL, Otero-Gonzlez AJ." Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus. DRAMP01088 GFKEVLKADLGSLVKGIAAHVAN 23 "Alyteserin-1Ma (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Alyteserin-1Ma has lower antimicrobial potencies (MIC>200 ?M). Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=214 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=214 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01089 GFKEVLKAGLGSLVKGIPAHVAN 23 "Alyteserin-1Mb (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Alyteserin-2Ma has lower antimicrobial potencies (MIC>200 ?M). Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=217 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=434 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01090 FIGKLISAASGLLSHL 16 "Alyteserin-2Ma (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial activity against the Gram-negative bacteria E. coli and Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 150 microM. Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=38.4 ?M) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=9.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01091 ILGAIIPLVSGLLSHL 16 "Alyteserin-2Mb (toads, amphibians, animals)" No entry found Not found Not found Alytes maurus (Midwife toad) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Has antibacterial activity against the Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 310 microM. Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=19.3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free -Amidation None L No cytotoxicity information found Not found 22800568 Toxicon. 2012 Nov;60(6):967-981. "K?nig E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C." "Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions." DRAMP01096 GIGSAILSAGKSALKGLAKGLAEHFAN 27 "Bombinin-like peptide 2 (BLP-2; toads, amphibians, animals)" P29003 Belongs to the bombinin family Not found Bombina orientalis (Oriental fire-bellied toad) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria. Tissue specificity: Expressed by the skin glands." "[Ref.1744108]Gram-negative bacterium: 58% inhibition Neisseria meningitidis 118V C (MIC=20 ?g/ml), 98% inhibition Neisseria meningitidis 15240 IAI (MIC=20 ?g/ml), 98% inhibition Neisseria meningitidis 126E IC1 (MIC=20 ?g/ml), 97% inhibition Neisseria gonorrhoeoe F62 (MIC=20 ?g/ml), 99% inhibition Neisseria Iactamica 15323 (MIC=20 ?g/ml), 100% inhibition Neisseria Iactamica 15215A (MIC=20 ?g/ml), 95% inhibition Neisseria cinerea 15461 (MIC=20 ?g/ml)." [Ref:1744108] No significant hemolytic activity was found which suggests a selectivity for prokaryotic over eukaryotic membranes. Cyclic Free Amidation None L No cytotoxicity information found Not found 1744108 J. Biol. Chem. 1991; 266: 23103-23111. "Gibson BW, Tang D, Mandrell R, Kelly M, Spindel ER." "Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis." DRAMP03017 FMPIIGRLMSGSL 13 "VESP-VB1 (Insects, animals)" No entry found Not found Not found vespine wasps Vespa bicolor "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has antimicrobial activities against standard strains and strong antimicrobial ability against drug-resistant strains. Among the tested drug-resistant strains, Pseudemonas aeruginosa and Staphylococcus aureus were the most sensitive for this kind of antimicrobial peptide. Has a little hemolytic activity." "[Ref.18723059] Gram-negative bacterium: Escherichia coli ATCC25922(MIC=7.5g/ml), Escherichia coli 23A(MIC=7.5g/ml), Escherichia coli 27A(MIC=15.0g/ml), Pseudemonas aeruginosa 3A(MIC=3.75g/ml), Pseudemonas aeruginosa 7A(MIC=3.75g/ml), ;## Gram-positive bacterium: Staphylococcus aureus ATCC2592(MIC=1.9g/ml), Staphylococcus aureus 6A(MIC=3.75g/ml), Staphylococcus aureus 15A(MIC=1.0g/ml);## Fungus: Candida albicans ATCC2002(MIC=30.0g/ml)" "[Ref.18723059] VESP-VB1 had a little hemolytic activity of 10.2% against rabbit red blood cells, and of 3.2% against human red blood cells with peptide concentration up to 200 g/ml" Linear Free Free None L No cytotoxicity information found Not found 18723059 Peptides. 2008 Nov;29(11):1887-1892. "Chen W, Yang X, Yang X, Zhai L, Lu Z, Liu J, Yu H." Antimicrobial peptides from the venoms of Vespa bicolor Fabricius. DRAMP01518 GILSLFTGGIKALGKTLFKMAGKAGAEHLACKATNQC 37 "Esculentin-2L (Frogs, amphibians, animals)" P82827 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana luteiventris (Great Basin spotted frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=3 M);##Gram-negative bacterium: Escherichia coli (MIC=6 M).##Yeast: Candida albicans (MIC=53 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01516 GLFSILRGAAKFASKGLGKDLTKLGVDLVACKISKQC 37 "Esculentin-2B (Frogs, amphibians, animals)" P82839 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana berlandieri (Rio Grande leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=1 M);##Gram-negative bacterium: Escherichia coli (MIC=1 M).##Yeast: Candida albicans (MIC=29 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 10651828 Eur J Biochem. 2000 Feb;267(3):894-900. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP02077 FLPIIAGIAAKVFPKIFCAISKKC 24 "Brevinin-1Pb (Frogs, amphibians, animals)" Q8QFQ5 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana pipiens (Northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=5 M);##Gram-negative bacterium: Escherichia coli (MIC=14 M).##Yeast: Candida albicans (MIC=7 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 10651828##12413397 Eur J Biochem. 2000 Feb;267(3):894-900.##Biochem J. 2003 Apr 1;371(Pt 1):125-130. "Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.##Chen T, Farragher S.M, Bjourson A.J, Orr D.F, Rao P, Shaw C." "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.##Granular gland transcriptomes in stimulated amphibian skin secretions." DRAMP01162 AGRGKQGGKVRAKAKTRSSRAGLQFPVGRVHRLLRKGNY 39 "Buforin-1 (Buforin I; Fragment of Histone H2A; toads, amphibians, animals)" P55897 Belongs to the histone H2A family Not found Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. PTM: Monoubiquitination of C-terminus gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties." "Gram-positive bacteria: Bacillus subtilis (MIC=4 ?g/ml), Staphylococcus aureus (MIC=4 ?g/ml), Streptococcus mutans (MIC=8 ?g/ml), Streptococcus pneumoniae (MIC=4 ?g/ml), Pseudomonas putida (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=4 ?g/ml), Serratia sp. (MIC=8 ?g/ml).##Fungi: Candida albicans (MIC=4 ?g/ml), Cryptococcus neoformans (MIC=4 ?g/ml), Saccharomyces cerevisiae (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free The residue at position 5 is N6-(2-hydroxyisobutyryl)lysine or N6-acetyllysine. The residue at position 9 is N6-(2-hydroxyisobutyryl)lysine or N6-lactoyllysine or N6-succinyllysine. The Lys13 has a interchain with G-Cter in ubiquitin. The Lys15 has a interchain with G-Cter in ubiquitin. The residue at position 36 is N6-(2-hydroxyisobutyryl)lysine. L No cytotoxicity information found DNA 8573171##8946958 Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.##FEBS Lett. 1996 Nov 25;398(1):87-90. "Park C.B, Kim M.S, Kim S.C.##Yi G.-S, Park C.B, Kim S.C, Cheong C." A novel antimicrobial peptide from Bufo bufo gargarizans.##Solution structure of an antimicrobial peptide buforin II. DRAMP01163 TRSSRAGLQFPVGRVHRLLRK 21 "Buforin-2 (Buforin II; Fragment of Histone H2A; toads, amphibians, animals)" P0DQL2 Belongs to the histone H2A family Not found Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed selective anticancer activity against 62 cancer cell lines (Lee 2008 Cancer Lett 271: 47-51). Buforin II is more potent than buforin I. PTM: Monoubiquitination of C-terminus gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties." "Gram-positive bacteria: Bacillus subtilis (MIC=2 ?g/ml), Staphylococcus aureus (MIC=4 ?g/ml), Streptococcus mutans (MIC=2 ?g/ml), Streptococcus pneumoniae (MIC=4 ?g/ml), Pseudomonas putida (MIC=2 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=1 ?g/ml), Serratia sp. (MIC=4 ?g/ml).##Fungi: Candida albicans (MIC=1 ?g/ml), Cryptococcus neoformans (MIC=1 ?g/ml), Saccharomyces cerevisiae (MIC=1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free The residue at position 21 is N6-(2-hydroxyisobutyryl)lysine L No cytotoxicity information found DNA 8573171##8946958 Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-413.##FEBS Lett. 1996 Nov 25;398(1):87-90. "Park C.B, Kim M.S, Kim S.C.##Yi G.-S, Park C.B, Kim S.C, Cheong C." A novel antimicrobial peptide from Bufo bufo gargarizans.##Solution structure of an antimicrobial peptide buforin II. DRAMP01188 LALKSGGWLRLFGLKDKKH 19 "Chensinin-1ZHa (Frogs, amphibians, animals)" No entry found Not found Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=9 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=35 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.22943378]No cytotoxicity information found Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01189 ATNIPFKVHFRCKAAFC 17 "Andersonin-W1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC>47 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>47 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=47 ?g/ml)." [Ref:22029824] It has no hemolytic activity against human red blood cells Cyclic Free Cyclization (Cys12 and Cys17) Disulfide bond between Cys12 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01190 AVNIPFKVHFRCKAAFC 17 "Andersonin-W2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=20.2 ?g/ml)." [Ref:22029824] It has no hemolytic activity against human red blood cells Cyclic Free Cyclization (Cys12 and Cys17) Disulfide bond between Cys12 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01191 GLFSKFAGKGIVNFLIEGVE 20 "Andersonin-X1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.3 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30.5 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01192 FLPKLFAKITKKNMAHIR 18 "Andersonin-Y1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=3.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=1.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=1.6 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01194 TSRCIFYRRKKCS 13 "Andersonin-C1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Show hemolytic activity against human red blood cells and obvious insulin-stimulating activity at the concentration of 50 ??g/mL. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>120 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml)." [Ref:22029824] It has 15.22.1% hemolytic activity at 50g/ml against human red blood cells Cyclic Free Free Disulfide bond between Cys4 and Cys12. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01195 FIFPKKNIINSLFGR 15 "Andersonin-D1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Golden crossband frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Weakly active against bacteria and fungi. Andersonin-D1 showes obvious insulin-stimulating activity at the concentration of 50 ??g/mL. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>126 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=16 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=16 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01199 RFIYMKGFGKPRFGKR 16 "Hejiangin-A1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana hejiangensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Hejiangin-A1 showes killing effects against the tested strains. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=25 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=25 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01200 IPWKLPATFRPVERPFSKPFCRKD 24 "Hejiangin-F1 (frog, amphibians, animals)" No entry found Not found Not found Odorrana hejiangensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=100 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=100 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=100 ?g/ml)." [Ref:22029824]Non-hemolytic activity against human red blood cells Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01201 AAPRGGKGFFCKLFKDC 17 "Schmackerin-C1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana schmackeri "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Schmackerin-C1 showes killing effects against the tested strains. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=50 ?g/ml); ##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=50 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys11 and Cys17) Disulfide bond between Cys11 and Cys17. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01208 SIITMTKEAKLPQLWKQIACRLYNTC 26 "Pleurain-A1 (Pleurain A1; Frogs, amphibians, animals)" "A8DY01, A8DY00, A8DY02, A8DY03, A8DY04, A8DY09, A8DY10, A8DY15" Not found Not found Rana pleuraden (Yunnan pond frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has little hemolytic activity on red blood cells. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=30 ?g/ml);##Gram-positive bacteria: Bacillus dysenteriae (MIC=120 ?g/ml), Staphylococcus aureus ATCC 2592 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml).." [Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 g/ml Cyclic Free Cyclization (Cys20 and Cys26) Disulfide bond between Cys20 and Cys26. L No cytotoxicity information found Not found 17764786 Peptides. 2007 Oct;28(10):2069-2074. "Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K." A new family of antimicrobial peptides from skin secretions of Rana pleuraden DRAMP01209 SIITMTKEAKLPQSWKQIACRLYNTC 26 "Pleurain-A2 (Pleurain A2; Frogs, amphibians, animals)" A8B5P0 Not found Not found Rana pleuraden (Yunnan pond frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has little hemolytic activity on red blood cells. Tissue specificity: Expressed by the skin dorsal glands." "[Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=30 ?g/ml);##Gram-positive bacteria: Bacillus dysenteriae (MIC=60 ?g/ml), Staphylococcus aureus ATCC 2592 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=30 ?g/ml)." [Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 g/ml Cyclic Free Cyclization (Cys20 and Cys26) Disulfide bond between Cys20 and Cys26. L No cytotoxicity information found Not found 17764786 Peptides. 2007 Oct;28(10):2069-2074. "Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K." A new family of antimicrobial peptides from skin secretions of Rana pleuraden. DRAMP01218 GFMKYIGPLIPHAVKAISDLI 21 "Kassinatuerin-1 (Frogs, amphibians, animals)" P0C010 Not found Not found Kassina senegalensis (Senegal running frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Shows broad-spectrum antimicrobial activity. Tissue specificity: Expressed by the skin dorsal glands." "Gram-negative bacteria: Escherichia coli (MIC=6.25 ?M), Klebsiella pneumoniae (MIC=25 ?M), Enterobacter cloacae (MIC=6.25 ?M), Pseudomonas aeruginosa (MIC=25 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 ?M), Staphylococcus epidermidis (MIC=6.25 ?M), Enterococcus faecalis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15885852]Display cytotoxicity against L929 fibroblasts (LD50=12M). Not found 10679222##15885852 Biochem Biophys Res Commun. 2000 Feb 16;268(2):433-436.##Peptides. 2005 Nov;26(11):2104-2110. "Mattute B, Knoop FC, Conlon JM.##Conlon JM, Abraham B, Galadari S, Knoop FC, Sonnevend A, P?l T." "Kassinatuerin-1: a peptide with broad-spectrum antimicrobial activity isolated from the skin of the hyperoliid frog, Kassina senegalensis.##Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives." DRAMP01237 GFMDTAKNVAKNVAVTLLDKLKCKITGGC 29 "Palustrin-2ISa (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana ishikawae "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?M), Staphylococcus aureus (MRSA) (MIC=100 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01251 VWPLGLVICKALKIC 15 "Dybowskin-4 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Dybowskin-4 has relatively greater hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=1.56 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=3.13 ?g/ml), Bacillus subtilis ATCC6633 (MIC=6.25 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=6.25 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=30 ?g/ml), Escherichia coli KCTC2433 (MIC=15 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=15 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=25 ?g/ml)." [Ref:17698251] It has 47.58% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys9 and Cys15) Disulfide bond between Cys9 and Cys15. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01252 GLFSVVTGVLKAVGKNVAKNVGGSLLEQLKCKKISGGC 38 "Dybowskin-5 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Dybowskin-5 has hemolytic activity against human red blood cells (hRBCs). "[Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=25 ?g/ml), Bacillus subtilis ATCC6633 (MIC=50 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 ?g/ml);##Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=50 ?g/ml), Escherichia coli KCTC2433 (MIC=60 ?g/ml), Klebsiella pneumoniae ATCC10031 (MIC=50 ?g/ml);##Yeast: Candida albicans ATCC36232 (MIC=50 ?g/ml)." [Ref:17698251] It has 17.84% hemolytic activity at 100 g/ml against human red blood cells Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 17698251 Peptides 2007; 28: 1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01253 FLPLLLAGLPLKLCFLFKKC 20 "Dybowskin-6 (Frogs, amphibians, animals)" No entry found Not found Not found Rana dybowskii (Korea brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Dybowskin-6 has relatively greater hemolytic activity against human red blood cells (hRBCs). "Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 ?g/ml), Staphylococcus aureus KCTC3881 (MIC=12.5 ?g/ml), Bacillus subtilis ATCC6633 (MIC=50 ?g/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 ?g/ml).##Yeast: Candida albicans (MIC=50 ?g/ml)." [Ref:17698251] It has 59.39% hemolytic activity at 100 g/ml against huamn red blood cells Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found [Ref:17698251]59.39% hemolytic activity at 100 g/ml against huamn red blood cells 17698251 Peptides. 2007 Aug;28(8):1532-1539. "Kim SS, Shim MS, Chung J, Lim DY, Lee BJ." Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. DRAMP01257 GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV 33 "Dermadistinctin-K (DD K; Frogs, amphibians, animals)" P83638 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix Not found "2K9B, 2JX6 resolved by NMR." "Function: Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes. Tissue specificity: Expressed by the skin glands." "Gram-positive bacteria: Staphylococcus aureus (MIC=4.7 ?M), Enterococcus faecalis (MIC>19 ?M);Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2.4 ?M), Escherichia coli (MIC=0.6 ?M).##Fungi: Candida tropicalis (MIC=10.1 ?M), Candida guilliermondii (MIC=20.3 ?M), Candida albicans (MIC=20.3 ?M), Candida albicans ATCC 1023 (MIC=10.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.10477123]No cytotoxicity information found liposomes 10477123 Peptides. 1999;20(6):679-686. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr." Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. DRAMP01258 ALWKTLLKNVGKAAGKAALNAVTDMVNQ 28 "Dermadistinctin-L (DD L; Frogs, amphibians, animals)" P83639 Not found Not found Phyllomedusa distincta (Monkey frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix Not found None "Function: Also has antiprotozoal activity against Trypanosoma cruzi. Decreases viability of murine peritoneal cells. Fuses to, and disrupts liposomes. Show little hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." "[Ref.10477123]Gram-positive bacteria: Staphylococcus aureus (MIC=1.3 ?M), Enterococcus faecalis (MIC=10 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=40 ?M), Escherichia coli (MIC=2.5 ?M);##[Ref.17442605]Fungi: Candida tropicalis (MIC=10.9 ?M), Candida guilliermondii (MIC=21.8 ?M), Candida albicans (MIC=21.8 ?M), Candida albicans ATCC 1023 (MIC=10.9 ?M)." [Ref:10477123]Show some hemolytic starting at 12.5 M against human blood Linear Free Free Free L [Ref.10477123]No cytotoxicity information found liposomes 10477123##12379643##17409003##17442605 Peptides. 1999;20(6):679-686.##J Biol Chem. 2002 Dec 20;277(51):49332-49340.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):329-335.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):336-343. "Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr.##Brand GD, Leite JR, Silva LP, Albuquerque S, Prates MV, Azevedo RB, Carregaro V, Silva JS, S?? VC, Brand??o RA, Bloch C Jr.##Silva LP, Leite JR, Brand GD, Regis WB, Tedesco AC, Azevedo RB, Freitas SM, Bloch C Jr.##Leite JR, Brand GD, Silva LP, K??ckelhaus SA, Bento WR, Ara??jo AL, Martins GR, Lazzari AM, Bloch C Jr." "Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: liposomes fusion and/or lysis investigated by fluorescence and atomic force microscopy.##Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity." DRAMP01288 FLSLIPHIVSGVASIAKHF 19 "Phylloseptin-1 (PSN-1; Frogs, amphibians, animals)" E3PQH3 Not found PSN-1 Phyllomedusa sauvagei (Sauvage's leaf frog) "Antimicrobial, Antibacterial, Antifungal" Homology Not found Not found None Function: PSN-1 displayed broad-spectrum activity against a range of planktonic organisms. "S. aureus (MIC=5 ?M), Escherichia coli and Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.20451254]No cytotoxicity information found Not found 20451254 Mol Immunol. 2010 Jul;47(11-12):2030-2037. "Zhang R, Zhou M, Wang L, McGrath S, Chen T, Chen X, Shaw C." Phylloseptin-1 (PSN-1) from Phyllomedusa sauvagei skin secretion: a novel broad-spectrum antimicrobial peptide with antibiofilm activity. DRAMP01301 FLSLIPHAINAVSAIAKHN 19 "Phylloseptin-1 (PS-1; Frogs, amphibians, animals)" P84566 Not found psn1 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (1 helices; 14 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JQ0 resolved by NMR. "Function: Atomic force microscopy experiments indicated that the bacteriolytic properties of these peptides might be related to their disruptive action on the cell membrane. PS-1 did not exhibit significant hemolytic activity on human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.15752569]Gram-positive bacteria: Staphylococcus aureus (MIC=7.9 ?M), Enterococcus faecalis (MIC=4.0 ?M);##Gram-negative bacteria: Escherichia coli (MIC=7.9 ?M), Psecdomonas aeruginosa (MIC=4 ?M), Psecdomonas aeruginosa wt (MIC=3 ?M)." "[Ref:15752569]0.3% hemolytic activity at 4 M, 0.57% hemolytic activity at 8 M, 0.6% hemolytic activity at 16 M, 0.98% hemolytic activity at 32 M, 1.98% hemolytic activity at 64 M against human red blood cells" Linear Free Amidation Free L [REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01302 FLSLIPHAINAVSTLVHHF 19 "Phylloseptin-2 (PS-2; Frogs, amphibians, animals)" "P85881, P84567, Q0VZ43" Not found psn2 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 14 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JPY resolved by NMR. "Function: Has antimicrobial activity. PS-2 did not exhibit significant hemolytic activity on human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.18656510][ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=15.1 ?M);##Gram-negative bacteria: Escherichia coli (MIC=60.4 ?M), Klebsiella pneumoniae (MIC=60.4 ?M), Pseudomonas aeruginosa (MIC=60.4 ?M);##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=7.6 ?M), S. agalactiae (MIC=1.9 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=60.4 ?M), A. calcoaceticus (MIC=3.7 ?M);##Fungi: Candida albicans (MIC=15.1 ?M)." "[Ref:15752569]0.1% hemolytic activity at 4 M, 0.28% hemolytic activity at 4 M, 0.7% hemolytic activity at 8 M, 0.8% hemolytic activity at 16 M, 1.05% hemolytic activity at 32 M, 2.05% hemolytic activity at 64 M against human red blood cells" Linear Free Amidation Free L [REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01303 FLSLIPHAINAVSALANHG 19 "Phylloseptin-3 (PS-3; Frogs, amphibians, animals)" P84568 Not found psn3 Phyllomedusa hypochondrialis (Orange-legged leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 11 residues) The antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.(Ref.2) 2JQ1 resolved by NMR. "Function: Has antimicrobial activity (By similarity). Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[ATCC Strains]: Gram-positive bacteria: S. aureus (MIC=32.9 ?M);##Gram-negative bacteria: Escherichia coli (MIC=65.6 ?M), Klebsiella pneumoniae (MIC=65.6 ?M), Pseudomonas aeruginosa (MIC=65.6 ?M). NOTE: Initial inoculum of 108 cells/Ml.##[Wild Type]: Gram-positive bacteria: S. aureus (MIC=8.2 ?M), S. agalactiae (MIC=4.1 ?M);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=32.8 ?M), A. calcoaceticus (MIC=4.1 ?M).##Fungi: Candida albicans (MIC=8.2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found Cell membrane 15752569##18656510 Peptides. 2005 Apr;26(4):565-573.##Peptides. 2008 Oct;29(10):1633-1644. "Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.##Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pil??-Veloso D, Bechinger B." "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.##Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations." DRAMP01319 RRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA 48 "Cathelicidin-AL (Gly-rich; Frogs, amphibians, animals)" No entry found Not found Not found Amolops loloensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=6.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 ?g/ml), Bacillus subtilis (MIC=100 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 ?g/ml), Psecdomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Psecdomonas aeruginosa ATCC27853 (MIC=6.25 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.22009138]No cytotoxic against HUVEC or RMMCs at the concentration of 0.4 mg/ml. Not found 22009138 Amino Acids. 2012 Aug;43(2):677-685. "Hao X, Yang H, Wei L, Yang S, Zhu W, Ma D, Yu H, Lai R." Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate. DRAMP01339 FLPIVGKLLSGLSGLL 16 "Amolopin-2a (Frogs, amphibians, animals)" No entry found Not found Not found Amolops loloensis (Rufous-spotted torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus (MIC=2.00 ?g/ml), Bacillus dysenteriae (MIC=1.50 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=3.00 ?g/ml).##Candida albicans (MIC=6.50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17000029]Display cytotoxicity against HepG2(IC50=77 mg/ml). Not found 17000029 Peptides. 2006 Dec;27(12):3085-3091. "Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R." "Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis." DRAMP01341 FLPLAVSLAANFLPKLFCKITKKC 24 "Amolopin-1b (Frogs, amphibians, animals)" A0SN42 Not found Not found Amolops loloensis (Rufous-spotted torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Staphylococcus aureus (MIC=5.50 ?g/ml), Bacillus dysenteriae (MIC=2.20 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=6.50 ?g/ml).##Yeast: Candida albicans (MIC=7.50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys18 and Cys24) Disulfide bridge between Cys18 and Cys24. L [Ref.17000029]Display cytotoxicity against HepG2(IC50=58 mg/ml). Not found 17000029 Peptides. 2006 Dec;27(12):3085-3091. "Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R." "Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis." DRAMP01346 VIGSILGALASGLPTLISWIKNR 23 "Prepromelittin-related peptide (Frogs, amphibians, animals)" A7BJK5 Not found prMRP Rana sakuraii (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).##Yeast: Candida albicans (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17174009]No cytotoxicity information found##[Ref.17826868]No cytotoxicity information found Not found 17174009##17826868 Peptides. 2007;28(3):505-514.##Peptides. 2007 Oct;28(10):2061-2068. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Suzuki H, Conlon JM, Iwamuro S." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.##Evidence that the genes encoding the melittin-related peptides in the skins of the Japanese frogs Rana sakuraii and Rana tagoi are not orthologous to bee venom melittin genes: developmental- and tissue-dependent gene expression. DRAMP01347 AIGSILGALAKGLPTLISWIKNR 23 "Prepromelittin-related peptide (Frogs, amphibians, animals)" A7BJK6 Not found prMRP Rana tagoi (Tago frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix Not found 6dst resolved by NMR (related PDB_ID) Function: Antibacterial activity against Gram-positive and Gram-negative bacteria. Antifungal activity against C. albicans. "[Ref.12804591]Gram-positive bacterium: Staphylococcus aureus (MIC=3.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=20 ?M).##Yeast: Candida albicans (MIC=19 ?M).##EL4 T-lymphoma cells (MIC=14 ?M).##[Ref.27271216]Gram-positive bacteria : Staphylococcuss aureus (MIC=6.25 M), Staphylococcus epidermidis (MIC=3.13 M), Bacillus subtilis (MIC=3.13 M);##Gram-negative bacteria : Escherichia coli (MIC=25 M), Pseudomonas aeruginosa (MIC=12.5 M), Klebsiella pneumoniae (MIC=12.5 M)" [Ref.27271216] 100% hemolysis at 20 M against human red blood cells Linear Free Amidation Free L [Ref.12804591]Display cytotoxic against L929 fibroblasts(LC50=20 M);EL4 T-lymphoma cells(LC50=14 M).##[Ref.27271216]L929 cells:Cell viability is approximately 10% at the concentration of 6.25?M. Not found 12804591##17174009##27271216 Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.##Peptides. 2007;28(3):505-514.##Sci Rep. 2016 Jun 8;6:27394. "Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pl T##Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji" "A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties##Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii##Design of an -helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity" DRAMP01350 FCTMIPIPRCY 11 "Tigerinin-1 (Frogs, amphibians, animals)" P82651 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=30 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=30 ?g/ml), Micrococcus luteus MT 166 (MIC=20 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=40 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=40 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=80 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys2 and Cys10. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01351 RVCFAIPLPICH 12 "Tigerinin-2 (Frogs, amphibians, animals)" P82652 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=20 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=40 ?g/ml), Micrococcus luteus MT 166 (MIC=20 ?g/ml).##Gram-negative bacteria: Pseudomonas putida NCIM 2102 (MIC=50 ?g/ml), Escherichia coli (MIC=50 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01352 RVCYAIPLPICY 12 "Tigerinin-3 (Frogs, amphibians, animals)" P82653 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacteria: Bacillus subtilis (MIC=30 ?g/ml), Staphylococcus aureus ATCC 8530 (MIC=30 ?g/ml), Micrococcus luteus MT 166 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=40 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=40 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=80 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01353 RVCYAIPLPIC 11 "Tigerinin-4 (Frogs, amphibians, animals)" P82654 Not found Not found Rana tigerina (Indian bull frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand-turn Not found None Function: Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. "Gram-positive bacterium: Staphylococcus aureus ATCC 8530 (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=60 ?g/ml), Pseudomonas putida NCIM 2102 (MIC=60 ?g/ml).##Fungi: Saccharomyces cerevisiae ATCC 8530 (MIC=100 ?g/ml)." [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 g/ml against rat erythrocytes. Cyclic Free Amidation;Cyclization (Cys3 and Cys11) Disulfide bond between Cys3 and Cys11. L No cytotoxicity information found Cell membrane 11031261 J Biol Chem. 2001 Jan 26;276(4):2701-2707. "Sai KP, Jagannadham MV, Vairamani M, Raju NP, Devi AS, Nagaraj R, Sitaram N." Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. DRAMP01354 LVRGCWTKSYPPKPCFVR 18 "Peptide leucine arginine (pLR; Frogs, amphibians, animals)" "Q90WP7, P82110" Not found Not found Rana pipiens (Northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide. Antiproliferative activity against human breast and ovarian tumor cell lines in vitro. Inhibits granulopoiesis in rat in vitro. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against Gram-positive bacteria: B.megaterium Bm11, S. lentus and M.luteus, and antifungal activity against C.tropicalis, C.guiller-mondii and P.nicotianae spores. Has hemolytic activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores." "[Ref.11099505]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=20 ?M), Staphylococcus lentus (MIC=50 ?M), Micrococcus luteus (MIC=10 ?M);##Fungi: Candida tropicalis (MIC=11 ?M), Candida guillermondii (MIC=6.6 ?M), Phytophthora nicotianae spores (MIC=75 ?M)." [Ref:11099505] It has 2.5% hemolytic activity at 100 M against human red blood Cyclic Free Free Disulfide bond between Cys5 and Cys15. L No cytotoxicity information found Not found 11099505 J. Biol. Chem. 2001;276:10145-10152. "Salmon A.L, Cross L.J.M, Irvine A.E, Lappin T.R.J, Dathe M, Krause G, Canning P, Thim L, Beyermann M, Rothemund S, Bienert M, Shaw C." "Peptide leucine arginine, a potent immunomodulatory peptide, isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens." DRAMP01355 FLGGLIKIVPAMICAVTKKC 20 "Ranalexin (Frogs, amphibians, animals)" P39084 Not found Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations. Tissue specificity: Expressed by the skin dorsal glands. Developmental stage: Expression starts at metamorphosis and continues into adulthood. PTM: Contains one disulfide bond 14-20." "Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=32 ?g/ml), Pseudomonas aeruginosa (MIC=128 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 8144672##9578480 J Biol Chem. 1994 Apr 8;269(14):10849-10855.##Eur J Biochem. 1998 Apr 1;253(1):221-228. "Clark DP, Durell S, Maloy WL, Zasloff M.##Vignal E, Chavanieu A, Roch P, Chiche L, Grassy G, Calas B, Aumelas A." "Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.##Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles." DRAMP01364 GLFGVLAKVAAHVVPAIAEHF 21 "Maculatin-1.1 (Frogs, amphibians, animals)" P82066 Not found Not found Litoria genimaculata (Green-eyed tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Alpha helix Not found None "Function: Maculatin-1.1 shows significant antibacterial activity against Gram-positive bacteria, less against Gram-negative bacteria. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Bacillus cereus (MIC=3 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=3 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=11.3 M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Not found 16140737##9620615##15203252 J Virol. 2005 Sep;79(18):11598-606. ##J Pept Sci. 1998 Apr;4(2):111-115.##Peptides. 2004; 25: 1035-1054. "VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. ##Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01370 MLCKLSMFGAVLGVPACAIDCLPMGKTGGSCEGGVCGCRKLTFKILWDKKFG 52 "Oh-defensin (O. hainana defensin; spiders, animals)" No entry found Not found Not found Ornithoctonus hainana (Venoms) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial and antifungal activities. "Gram-positive bacteria: Staphylococcus aureus (MIC=1.25 ?g/ml), Bacillus cereus (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=1.25 ?g/ml), Bacillus dysenteriae (MIC=1.25 ?g/ml), Pseudomonas aeruginosa (MIC=5 ?g/ml).##Yeast: Candida albicans (MIC=1.25 ?g/ml)." "[Ref.21538709] It has little hemolytic activity, inducing 7% hemolysis at the concentration up to 200 ?g/ml (about 36 ?M)." Cyclic Free Free Has three disulfide bonds L No cytotoxicity information found Not found 21538709 J Pept Sci. 2011 Jul;17(7):540-544. "Zhao H, Kong Y, Wang H, Yan T, Feng F, Bian J, Yang Y, Yu H." "A defensin-like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana." DRAMP01371 GLLSGILGAGKHIVCGLTGCAKA 23 "Odorranain-NR (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Combine helix and strand structure "Odorranain-NR has a large proportion of beta-sheet. In Tris HCl + SDS, odorranain-NR has a major conformation of beta-sheet (79.2%) and a minor conformation of beta-turn (1.3%). In Tris HCl, the beta-sheet has been decreased to 57.1% and the beta-turn has been increased to 10.5%. The beta-sheet has been decreased to 39.8% in water." None "Function: Odorranain-NR exhibits antimicrobial activity against the tested strains except E. coli ATCC25922. Odorranain-NR has little hemolytic activity on red blood cells even with peptide concentration up to 100 mg/ml. PTM: Odorranain-NR has an intramolecular disulfide-bridged hexapeptide segment, which is a new type of disulfide-bridge motif in amphibian antimicrobial peptides." "[Ref.18282640]Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=9.375 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 ?g/ml), Bacillus dysenteriae (MIC=37.5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=18.75 ?g/ml)." [Ref:18282640] It has little hemolytic activity at 100 g/ml against rabbit red blood cells Cyclic Free Free Disulfide bond between Cys15 and Cys20. L No cytotoxicity information found Not found 18282640 Peptides. 2008 Apr;29(4):529-535. Che Q et al Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami. DRAMP02244 GLFLDTLKGAAKDVAGKLLEGLKCKIAGCKP 31 "Ranatuerin-2Ca (Ranatuerin 2Ca; Frogs, amphibians, animals)" P82878 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide has defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, male-specific defense response to bacterium, antibacterial humoral response, antibacterial humoral response, induced systemic resistance, antifungal innate immune response, antifungal humoral response, defense response to fungus (incompatible interaction) in GO analysis. Tissue specificity: Expressed by the skin glands. PTM: Disulfide bond at position 24 and 29." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys24 and Cys29. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP01357 FLGGLMKAFPAIICAVTKKC 20 "Ranalexin-1Cb (Ranatuerin 1Cb; Frogs, amphibians, animals)" P82877 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide has defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, male-specific defense response to bacterium, antibacterial humoral response, antibacterial humoral response, induced systemic resistance, antifungal innate immune response, antifungal humoral response, defense response to fungus (incompatible interaction) in GO analysis. Tissue specificity: Expressed by the skin glands." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys14 and Cys20) Disulfide bond between Cys14 and Cys20. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP02246 SMLSVLKNLGKVGLGLVACKINKQC 25 "Ranatuerin-1C (Ranatuerin 1C; Frogs, amphibians, animals)" P82875 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Rana clamitans (Green frog) (Lithobates clamitans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Tissue specificity: Expressed by the skin glands." [Ref.10822101] Gram-positive bacterium: Staphylococcus aureus (MIC=55 M);##Gram-negative bacterium: Escherichia coli (MIC=1.5 M).##Yeast: Candida albicans (MIC=58 M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys19 and Cys25) Disulfide bond between Cys19 and Cys25. L No cytotoxicity information found Not found 10822101 Peptides. 2000 Apr;21(4):469-476. "Halverson T, Basir YJ, Knoop FC, Conlon JM." Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. DRAMP01394 GLLRASSVWGRKYYVDLAGCAKA 23 "Odorranain-W2 (Frogs, amphibians, animals)" A7YL71 Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Shows antibacterial and antifungal activities. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?g/ml), Bacillus dysenteriae (MIC=30 ?g/ml), Helicobacter pylori NCTC 11637 (MIC=20 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml).##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17698252]No cytotoxicity information found Not found 17698252 Peptides. 2007 Aug;28(8):1527-1531. "Chen L, Li Y, Li J, Xu X, Lai R, Zou Q." An antimicrobial peptide with antimicrobial activity against Helicobacter pylori. DRAMP01395 VVKCSYRLGSPDSQCN 16 "Odorranain-A-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=35.2 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=17.6 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Free Disulfide bond between Cys4 and Cys15. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01396 GFMDTAKNVAKNMAGNLLDNLKCKITKAC 29 "Odorranain-F-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=2.5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=2.5 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01397 GFMDTAKNVAKNMAVTLLDNLKCKITKAC 29 "Odorranain-F-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.5 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.8 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01398 GFMDTAKNVAKNEAGNLLDNLKCKITKAC 29 "Odorranain-F-OA3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=6.3 ?g/ml)." [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01399 GFMATAKNVAKNMDVTLLDNLKCKITKAC 29 "Odorranain-F-OA4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=4.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP18395 FFGHLFRGIINVGKHIHGLLSG 22 "moroPC-NH2 (moronecidin-like peptide; fish, animals)" No entry found Not found Not found Parachaenichthys charcoti "Antimicrobial, Antibacterial, Antifungal" Not found Not found None Comment: No comments found on DRAMP database "Active against Gram- E. cloacae ATCC 13047 (MIC 25 uM), S. sonnei (ATCC 29930) (MIC 5 uM), Psychrobacter sp. (PAMC 25501) (MIC 2.5 uM), E. coli DH5alpha (MIC 5 uM), Gram+ E. faecalis (ATCC 29212) (MIC 25 uM), S. pyogenes (ATCC 19615) (MIC 2.5 uM), S. aureus (ATCC 33591), L. monocytogenes (ATCC 15313) (MIC 5 uM), and yeast C. tropicalis (ATCC 20115) (MIC 5 uM). " No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.28122029]No cytotoxicity information found Not found 28122029 PLoS One. 2017 Jan 25;12(1):e0170821. "Shin SC, Ahn IH, Ahn DH, Lee YM, Lee J, Lee JH, Kim HW, Park H" Characterization of Two Antimicrobial Peptides from Antarctic Fishes (Notothenia coriiceps and Parachaenichthys charcoti) DRAMP01401 GFMNTAKNVAKNVAVTLLDNLKCKITGGC 29 "Odorranain-F-OW1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=2 ?M), Pseudomonas aeruginosa (MIC=4 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01402 GLFTLIKGAYKLDAPTVACN 20 "Odorranain-J-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ?g/ml)##Yeast: Candida albicans ATCC 2002 (MIC=20.1 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01403 GLFTLIKGAYKNDAPTVACN 20 "Odorranain-J-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Weakly active against bacteria and fungi. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=40.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=40.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=20.1 ?g/ml)." [Ref:22029824]Not found Linear Free Free Free L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01409 GILSGILGVGKKLVCGLSGLC 21 "Nigrocin-OR1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=4 ?M), Pseudomonas aeruginosa (MIC=7 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=2 ?M).##Yeast: Candida albicans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01410 GILSGILGVGKMLVCGLSGLC 21 "Nigrocin-OR2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Bacillus pyocyaneus CMCCB 10104 (MIC=5 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01411 GILSGLLGVGKMLVCGLSGLC 21 "Nigrocin-OR3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana rotodora (Chinese odorous frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Bacillus pyocyaneus CMCCB 10104 (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01414 GIFSTVFKAGKGIVCGLTGLC 21 "Nigrocin-2ISa (Frogs, amphibians, animals)" F1T156 Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L [Ref.21193000]No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01415 GILGTVFKAGKGIVCGLTGLC 21 "Nigrocin-2ISb (Frogs, amphibians, animals)" F1T157 Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01416 GILSTVFKAGKGIVCGLSGLC 21 "Nigrocin-2ISc (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana ishikawae (Ishikawa's frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 ?M).##Yeast: Candida albicans (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 21867685 Biochem Biophys Res Commun. 2011 Sep 9;412(4):673-677. "Iwakoshi-Ukena E, Soga M, Okada G, Fujii T, Sumida M, Ukena K." Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning. DRAMP01418 GLFGKILGVGKKVLCGLSGMC 21 "Nigrocin-2GRb (Frogs, amphibians, animals)" No entry found Not found Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial against the Gram-negative bacterium E. coli and the Gram-positive bacterium S. aureus. Also has a weak hemolytic activity against human erythrocytes. [Ref.16621155]Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=3 ?M);##Yeast: Candida albicans (MIC=50 ?M). [Ref:16621155] LC50=40 M against human erythrocytes Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 16621155 Peptides. 2006 Sep;27(9):2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami." DRAMP01420 GLLSGILGAGKHIICGLSGLC 21 "Nigrocin-OG4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC>100 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?g/ml), Bacillus subtilis (MIC>100 ?g/ml).##Yeast: Candida albicans (MIC=1.10 ?g/ml)." "[Ref.17272268] RCH=65.5 7.7% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01421 GLLSGILGAGKQKVCGLSGLC 21 "Nigrocin-OG5 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=9.37 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=18.75 ?g/ml), Bacillus subtilis (MIC=37.50 ?g/ml).##Yeast: Candida albicans (MIC=4.68 ?g/ml)." "[Ref.17272268] RCH=87.2 2.6% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01422 GLLSGVLGVGKKVLCGLSGLC 21 "Nigrosin-OG21 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=4.68 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml).##Yeast: Candida albicans (MIC=4.68 ?g/ml)." "[Ref.17272268] RCH=100% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01423 GLLSGILGAGKHIVCGLSGLR 21 "Nigrosin-OG13 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana grahami (Yunnanfu frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC=4.68 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml).##Yeast: Candida albicans (MIC=1.10 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17272268]No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01426 GLLSGVLGVGKKIVCGLSGLC 21 "Nigrocin-1-OA1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=5.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01427 GIFGKILGVGKKTLCELSGMC 21 "Nigrocin-1-OA2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.3 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01428 GIFLKVLGVGKKVLCGVSGLC 21 "Nigrocin-1-OA3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=10.8 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01429 GLISGILGVGKKLVCGLSGLC 21 "Nigrocin-1-OR1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=11.5 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01430 GLISGILGVGKMLVCGLSGLC 21 "Nigrocin-1-OR2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=8.6 ?g/ml)" [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01431 GLISGLLGVGKMLVCGLSGLC 21 "Nigrocin-1-OR3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.4 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=10.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01432 GILGNIVGMGKKIVCGLSGLC 21 "Nigrocin-1-OW2 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.2 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01433 GILGNIVGMGKKVVCGLSGLC 21 "Nigrocin-1-OW3 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.3 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=6.7 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01434 GILSGVLGMGKKIVCGLRGLC 21 "Nigrocin-1-OW4 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=14.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.6 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=7.2 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01435 GILGNIVGMGKQVVCGLSGLC 21 "Nigrocin-1-OW5 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=10.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.1 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=5.1 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01436 GILSGVLGMGKKIVCGLSGLC 21 "Nigrocin-1-OW1 (Frogs, amphibians, animals)" No entry found Not found Not found Odorrana andersonii (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "[Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.8 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=4.4 ?g/ml)." [Ref:22029824] Not found in the literature Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. DRAMP01438 GIFGKILGAGKKVLCGLSGLC 21 "Nigrocin-2JDa (Frogs, amphibians, animals)" B3A0M6 Not found Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity against rabbit erythrocytes. PTM: contains one disulfide bond 15-21. " "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Staphylococcus aureus CIB 85462 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=16 ?M), Escherichia coli CIB 84492 (MIC=16 ?M);##Yeast: Candida albicans (MIC=63 ?M)." [Ref:22917879] It has 80.3 5.5% hemolytic activity at 128 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP01439 GIFGKILGVGKKVLCGLSGMC 21 "Nigrocin-2JDb (Odorranain-H2; Frogs, amphibians, animals)" B3A0M7 Not found Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity against rabbit erythrocytes. PTM: contains one disulfide bond 15-21. " "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15 ?M), Staphylococcus aureus CIB 85462 (MIC=15 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25992 (MIC=8 ?M), Escherichia coli CIB 84492 (MIC=8 ?M);##Yeast: Candida albicans (MIC=31 ?M)." [Ref:22917879] It has 88.4 4.2% hemolytic activity at 128 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys15 and Cys21) Disulfide bond between Cys15 and Cys21. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP01447 GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC 37 "Esculentin-2CHa (Frogs, amphibians, animals)" No entry found Not found Not found Lithobates chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: E. coli (MIC=5 ?M), K. pneumoniae (MIC=5 ?M), P. aeruginosa (MIC=5 ?M);##Gram-positive bacterium: S. aureus (MIC=5 ?M).##Yeast: C. albicans (MIC=10 ?M)." [Ref.21262304] LC50=150 ?M against human erythrocytes Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 21262304 Peptides. 2011 Apr;32(4):664-669. "Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01452 RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC 47 "Esculentin-1LTa (Frogs, amphibians, animals)" No entry found Not found Not found Hylarana latouchii (Broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=0.6 ?M), Bacillus licheniformis X39 (MIC=10 ?M), Staphylococcus carnosus KHS (MIC=1.3 ?M), Rhodococcus rhodochrous X15 (MIC=0.3 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 ?M), Serratia rubidaea X01 (MIC=10 ?M), Psychrobacter faecalis X29 (MIC=0.6 ?M).##Yeast: Candida albicans ATCC2002 (MIC=80 ?M)." [Ref.22426384] LD50>480 M against human erythrocytes Cyclic Free Cyclization (Cys41 and Cys47) Disulfide bond between Cys41 and Cys47. L No cytotoxicity information found Not found 22426384 Biochimie. 2012 Jun;94(6):1317-1326. "Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J." "Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii." DRAMP01456 GLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC 37 "Esculentin-2PLa (Frogs, amphibians, animals)" "A7WNV5, D3UA57" Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against the Gram-negative bacterium E. coli, the Gram-positive bacterium: S. aureus and the yeast C. albicans. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 31-37." Gram-negative bacterium: Escherichia coli (MIC=1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=10 ?M).##Yeast: Candida albicans (MIC=49 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01479 GLFSKLNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC 46 "Esculentin-1CPa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates capito (North American New World frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. [Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Yeast: Candida albicans (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 19635516 Peptides. 2009 Oct;30(10):1775-1781. "Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). DRAMP01480 GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC 37 "Esculentin-2CPa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates capito (North American New World frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Active against bacteria and fungi. [Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Yeast: Candida albicans (MIC=25 ?M) No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 19635516 Peptides. 2009 Oct;30(10):1775-1781. "Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). DRAMP01483 RIFSKIGGKAIKNLILKGIKNIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1ISb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Japanese Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity. "Gram-negative bacterium: Escherichia coli (MC=3.1 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=12.5 ?M), Bacillus subtilis (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01484 GIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC 37 "Esculentin-2ISa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Japanese Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity. "Gram-negative bacterium: Escherichia coli (MC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus aureus (MRSA) (MIC=25 ?M), Bacillus subtilis (MIC=6.3 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP01486 GLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1GRa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grahami (Odorrana andersonii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Shows antibacterial activity, also activity against fungus C. albicans." Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 ?M).##Yeast: Candida albicans (MIC>50 ?M). [Ref.16621155] LC50=210 M against human erythrocytes. Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 16621155 Peptides 2006; 27: 2111-2117. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H." "Antimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami." DRAMP01493 GLFSKFVGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=1.2 ?g/mL), Staphylococcus aureus ATCC 25923 (MIC=1.2 ?g/mL).##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.4 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01494 GLFSKFSGKGIKNFLIKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC 46 "Esculentin-1-OA2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 ?g/mL);##Gram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=2.5 ?g/mL), Staphylococcus aureus ATCC 25923 (MIC=1.3 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.3 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01495 GLFSKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.4 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.4 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.7 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01496 GLFTKFAGKGIKDLIFKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2.8 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=2.8 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=5.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01497 GLFSKFAGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC 46 "Esculentin-1-OA5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.4 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1.7 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.4 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.7 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01499 GIFSKISGKAIKNLFIKGAKNVGKEVGMDVVRTGIDVVGCKIKGEC 46 "Esculentin-1-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.4 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=17.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01501 GIFSKISGKAIKNLFIKGAKNVGKRVGMDVVRTGMDVVGCKIKGEC 46 "Esculentin-1-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=5.5 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=11 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=11 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=11 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01502 GIFSKISGKAIKNLFIKGAENVGKHVGIDVVRTGIDVVGCKIKGEC 46 "Esculentin-1-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01503 GIFSKISGKAIKNLFIKGAKNVGKEVGIDVVRTGMDVVGCKIKGEC 46 "Esculentin-1-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=4.1 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.1 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01504 GIFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC 37 "Esculentin-2-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.5 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.3 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=4.3 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.5 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01505 GLFTLIKGAAKLIGKTTAKEAGKTGKLEMACKITNQC 37 "Esculentin-2-OA2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01507 GVFTLIKGATQLIGKTLGKELGKTGLELMACKITNQC 37 "Esculentin-2-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=10.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=21.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=10.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01508 GVFTLIKGATQLIGKTLGKEVGKTGLELMACKITKQC 37 "Esculentin-2-OR2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.1 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4.1 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=16.2 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.1 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01509 GVFTLLKGATQLIGKTLGKELGKTGLELMACKITNQC 37 "Esculentin-2-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=7.9 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=7.9 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=15.8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01510 GVFTLIKGATQLIGKTLGKELGKTGLELMACKITEQC 37 "Esculentin-2-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.6 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3.6 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.6 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=3.6 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01511 GVFTLIKGATQLIGKTLGKELGKTGLEIMACKITKQC 37 "Esculentin-2-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=15.8 ?g/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15.8 ?g/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ?g/mL).##Yeast: Candida albicans ATCC 2002 (MIC=7.9 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L [Ref.22029824]No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP01513 GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC 46 "Esculentin-1 (Frogs, amphibians, animals)" P32414 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. Has hemolytic activity. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.2 ?M), Pseudomonas aeruginosaATCC15692 (MIC=0.7 ?M);##Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.1 ?M), Staphylococcus aureus Cowan1 (MIC=0.4 ?M).##Fungi: Candida albicans (MIC=0.5 ?M), Saccharomyces cerevisiae (MIC=0.9 ?M)." [Ref. 8163497] LC>100M Cyclic Free Cyclization (Cys40 and Cys46) Disulfide bond between Cys40 and Cys46. L [Ref.8508915]No cytotoxicity information found Not found 8508915 FEBS Lett. 1993 Jun 14;324(2):159-161. "Simmaco M, Mignogna G, Barra D, Bossa F." Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. DRAMP01524 SIRDKIKTIAIDLAKSAGTGVLKTLICKLDKSC 33 "Rugosin-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has weak hemolytic activity gainst rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.69 ?g/ml), Bacillus subtilis (MIC=9.38 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=5.63 ?g/ml)" [Ref:19778602]Show weak hemolytic activity against rabbit red cells Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01525 SIRDKIKTIAIDLAKSAGMGILKTLICKLDKSC 33 "Rugosin-RN3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=16.51 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=15.00 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01526 SIRDKIKTIAIDLAKSAGTGVLKTLICKLNKSC 33 "Rugosin-RN5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=15.00 ?g/ml), Staphylococcus aureus ATCC43300 (MRSA) (MIC=12.50 ?g/ml), Bacillus subtilis (MIC=18.75 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=18.75 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bridge between Cys27 and Cys33. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01539 FKTWKRPPFQTSCWGIIKE 19 "Nigroain-C2 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=27.50 ?g/ml), S. aureus ATCC43300 (MIC=55.00 ?g/ml), Bacillus subtilis (MIC=110.00 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=110.00 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=55.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=55.00 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=13.75 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01543 DCTRWIIGINGRICRD 16 "Nigroain-E1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells. [Ref.19778602]Gram-positive bacterium: Staphylococcus aureus ATCC25923 (MIC=18.75 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=75 ?g/ml). [Ref:19778602]7.621.6% hemolytic activity at 100 ?g/ml against rabbit red cells Cyclic Free Free Disulfide bridge between Cys2 and Cys14. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01546 SLWETIKNAGKGFIQNLDKIR 21 "Nigroain-K1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. Also has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=21.88 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=32.74 ?g/ml)." [Ref:19778602]22.49 4.8% hemolytic activity at 100 ?g/ml against rabbit red cells Linear Free Free Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01547 SLWETIKNAGKGFILNILDKIRCKVAGGCKT 31 "Nigroain-K2 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata (Black-striped frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. Also has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=11.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=9.38 ?g/ml);##Gram-positive bacteria: Escherichia coli ML-35P (MIC=25.00 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=25.00 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25.00 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=15.00 ?g/ml)" [Ref:19778602]85.52 3.26% hemolytic activity at 50 ?g/ml against rabbit red cells Cyclic Free Free Disulfide bridge between Cys23 and Cys29. L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01560 GLFGVLGSIAKHVLPHVVPVIAEKL 25 "Caerin-1.9 (Frogs, amphibians, animals)" P81252 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria chloris (Blue-thighed frog) (frog skin active peptide family) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin dorsal glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation. Miscellaneous: Caerin 1.9 completely inhibited HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606)." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=50 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=1.2 M);inhibition of HIV transfer by dendritic cells to T cells(IC50=1.6 M).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 20 ?M." Not found 26026377##16140737##15203252##9516047 Peptides. 2015 Sep;71:296-303. ##J Virol. 2005 Sep;79(18):11598-606. ##Peptides. 2004 Jun;25(6):1035-1054.##J Pept Res. 1998 Feb;51(2):121-126. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria." DRAMP01627 YPPKPESPGEDASPEEMNKYLTALRHYINLVTRQRY 36 "Skin peptide tyrosine-tyrosine (Skin-PYY; SPYY; Frogs, amphibians, animals)" P80952 Belongs to the NPY family Not found Phyllomedusa bicolor (Two-colored leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria, yeast and fungi. Tissue specificity: Skin. PTM: C-terminal amidation (By similarity)." "Gram-negative bacteria: Aeromonas caviae (MIC=40 ?g/ml), Escherichia coli (MIC=10 ?g/ml);##Gram-positive bacteria: Enterococcus faecalis (MIC=10 ?g/ml), Nocardia brasiliensis (MIC=20 ?g/ml).##Fungi: Cryptococcus neoformans (MIC=20 ?g/ml), Candida albicans (MIC=15 ?g/ml), Microsporum canis (MIC=10 ?g/ml), Tricophyton rubrum (MIC=15 ?g/ml), Arthroderma simii (MIC=10 ?g/ml), Aspergillus fumigatus (MIC=80 ?g/ml), Aspergillus niger (MIC>100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.8601432]<20% cytotoxic against murine macrophages at the concentration up to 100g/ml##[Ref.7937944]No cytotoxicity information found Cell membrane 7937944##8601432 Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10295-10299.##FEBS Lett. 1996 Feb 19;380(3):237-240. "Mor A, Chartrel N, Vaudry H, Nicolas P.##Vouldoukis I, Shai Y, Nicolas P, Mor A." "Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.##Broad spectrum antibiotic activity of the skin-PYY." DRAMP01638 GLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS 32 "Dermaseptin-L1 (Frogs, amphibians, animals)" No entry found Not found Not found Hylomantis lemur (Lemur leaf frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=8 ?M).##Fungi: Batrachochytrium dendrobatidis (MIC>100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.17561225]Displayed cytotoxic against HepG2 cells(LC50=45M) Not found 17561225 Toxicon. 2007 Sep 15;50(4):498-506. "Conlon JM, Woodhams DC, Raza H, Coquet L, Leprince J, Jouenne T, Vaudry H, Rollins-Smith LA." Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae). DRAMP01646 GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV 33 "Adenoregulin (Dermaseptin BII; Dermaseptin B2; Frogs, amphibians, animals)" "P31107, P80283" Belongs to the frog skin active peptide family (Dermaseptin subfamily) ADR Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Fountion: Enhances binding of agonists to adenosine A1 receptors, adenosine A2a receptors, alpha-2 adrenergic receptors and 5-hydroxytryptamine 1A receptors. Enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. Affects human behavior eliciting profound malaise, followed by listlessness and then euphoria. Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Lack hemolytic activity. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation at V33 (Amidation in vitro increases antimicrobial activity against some microorganisms such as T. album and S. cerevisia)." "[Ref.8306981]Fungi: Microsporum canis (IP 1194) (MIC=10 ?g/ml), Tricophyton rubrum (IP 1400-82) (MIC=15 ?g/ml), Arthroderma simii (IP 1063-74) (MIC=30 ?g/ml), Aspergillus fumigatus IP (1025-70) (MIC=125 ?g/ml), Aerornonas caviae (IP 67-16 T) (MIC=60 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 ?g/ml), Candida albicans (IP 884-65) (MIC=15 ?g/ml);##Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=15 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=30 ?g/ml)." [Ref:8306981]Lack hemolytic activity against rabbit red blood cells Linear Free Free Free L [Ref.8306981]No cytotoxicity information found##[Ref.1438301]No cytotoxicity information found##[Ref.7842473]No cytotoxicity information found##[Ref.8565049]No cytotoxicity information found Not found 8306981##1438301##7842473##8565049 "Eur J Biochem 1994, 219 (1-2):145-154.##Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-10963.##Cell Mol Neurobiol. 1994 Apr;14(2):133-157.##Cell Mol Neurobiol. 1995 Aug;15(4):465-493." "Mor, A, Nicolas, P.##Daly JW, Caceres J, Moni RW, Gusovsky F, Moos M Jr, Seamon KB, Milton K, Myers CW.##Shin Y, Moni RW, Lueders JE, Daly JW.##Moni RW, Romero FS, Daly JW." "Isolation and structure of novel defensive peptides from frog skin.##Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor.##Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx.##The amphiphilic peptide adenoregulin enhances agonist binding to A1-adenosine receptors and [35S]GTP gamma S to brain membranes." DRAMP01648 GLVTSLIKGAGKLLGGLFGSVTGGQS 26 "Dermaseptin-like PBN2 (DRP-PBN2; Plasticin-B1a; Frogs, amphibians, animals)" Q800R4 Not found Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Possesses a potent antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and fungi. Probably acts by disturbing membrane functions with its amphipathic structure." "Gram-negative bacteria: Escherichia coli B (MIC=1.5 ?M), Salmonella typhimurium (MIC=3.1 ?M), Salmonella enteritidis (MIC=1.5 ?M), Enterobacter cloacae (MIC=12.5 ?M), Klebsiella pneumoniae (MIC=0.8 ?M);##Gram-positive bacteria: Aerococcus viridans (MIC=3.1 ?M), Bacillus megaterium (MIC=0.8 ?M), Staphylococcus aureus (MIC=3.1 ?M), Staphylococcus haemolyticus (MIC=0.8 ?M).##Fungi: Saccaromyces cerevisiae (MIC=3.1 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.12709067]No cytotoxicity information found##[Ref.15222751]No cytotoxicity information found Not found 12709067##15222751 Eur J Biochem. 2003 May;270(9):2068-2081.##Biochemistry. 2004 Jul 6;43(26):8391-8409. "Vanhoye D, Bruston F, Nicolas P, Amiche M.##Vanhoye D, Bruston F, El Amri S, Ladram A, Amiche M, Nicolas P." "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Membrane association, electrostatic sequestration, and cytotoxicity of Gly-Leu-rich peptide orthologs with differing functions." DRAMP01649 AMWKDVLKKIGTVALHAGKAALGAVADTISQ 31 "Dermaseptin-BI (Dermaseptin B1; Frogs, amphibians, animals)" P80282 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation (Potential)." "Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=15 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=30 ?g/ml).##Fungi: Tricophyton rubrum (IP 1400-82) (MIC=15 ?g/ml), Microsporum canis (IP 1194) (MIC=10?g/ml), Arthroderma simii (IP 1063-74) (MIC=30 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neofonnans (IP 962-67) (MIC=15 ?g/ml), Aspergillus fumigatus (IP 1025-70)(MIC=125 ?g/ml), Aerornonas caviae (IP 67-16 T) (MIC=60 ?g/ml), Candida albicans (IP 884-65) (MIC=15 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.8306981]No cytotoxicity information found##[Ref.8074751]No cytotoxicity information found Not found 8306981##8074751 Eur J Biochem. 1994 Jan 15;219(1-2):145-154.##J Biol Chem. 1994 Jul 8;269(27):17847-17852. "Mor A, Nicolas P.##Amiche M, Ducancel F, Mor A, Boulain JC, Menez A, Nicolas P." "Isolation and structure of novel defensive peptides from frog skin.##Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins." DRAMP01668 ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ 34 "Dermaseptin-1 (DS I; Dermaseptin-S1, DS1; Frogs, amphibians, animals)" "P24302, P80277" Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa sauvagei (Sauvage's leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (CD) Not found None "Function: Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. This peptide could also inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). Tissue specificity: Expressed by the skin glands." "Fungi: Microsporum canis (IP 1194) (MIC=50 ?g/ml), Tricophyton rubrum (IP 1400-82) (MIC=100 ?g/ml), Arthroderma simii (IP 1063-74) (MIC=100 ?g/ml), Aspergillus fumigatus (IP 1025-70) (MIC=100 ?g/ml), Aerornonas caviae IP (67-16) T (MIC=50 ?g/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 ?g/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 ?g/ml), Candida albicans (IP 884-65) (MIC=60 ?g/ml); ##Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=5 ?g/ml);##Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=200 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free Free L [Ref.1909573]No cytotoxicity information found##[Ref.8306981]No cytotoxicity information found Cell membrane 1909573##8306981 Biochemistry. 1991 Sep 10;30(36):8824-8830.##Eur J Biochem. 1994 Jan 15;219(1-2):145-154. "Mor A, Nguyen VH, Delfour A, Migliore-Samour D, Nicolas P.##Mor A, Nicolas P." "Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin.##Isolation and structure of novel defensive peptides from frog skin." DRAMP01764 FLPILGKLLSGIL 13 "Temporin-1TGa (Frogs, amphibians, animals)" Q2PGA8 Belongs to the frog skin active peptide family (Brevinin subfamily) tmpTGa Rana tagoi (Tago frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=15 ?M);##Gram-negative bacterium: Escherichia coli (MIC>100 ?M).##Yeast: Candida albicans. No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.12804591]No cytotoxicity information found##[Ref.16675060]No cytotoxicity information found Not found 12804591##16675060 Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.##Peptides. 2006 Sep;27(9):2124-2128. "Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, P??l T.##Iwamuro S, Nakamura M, Ohnuma A, Conlon JM." "A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties.##Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi." DRAMP01776 FLPIVTNLLSGLLGK 15 "Temporin-1Sb (Temporin-SHb; Frogs, amphibians, animals)" B3KYH5 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-1Sb Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Activity against Gram-positive and Gram-negative bacteria, and has strong hemolytic activity against human erythrocytes." "[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=58 ?M), Enterococcus faecalis ATCC 29212 (MIC>116 ?M), Bacillus megaterium (MIC=46 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=231 ?M), Escherichia coli ATCC 35218 (MIC>116 ?M);##Fungi: Aspergillus flavus (MIC=58 ?M)." [Ref:18584916]LC50>116 M against human erythrocytes Linear Free Amidation Free L [Ref.18584916]No cytotoxicity information found Not found 18584916 Peptides. 2008 Sep;29(9):1526-1523. "Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A" "Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica." DRAMP01777 FLSHIAGFLSNLFGK 15 "Temporin-1Sc (Temporin-SHc; Frogs, amphibians, animals)" B3KYH6 Belongs to the frog skin active peptide family (Brevinin subfamily) preproTemp-1Sc Pelophylax saharicus (Sahara frog) (Rana saharica) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and has hemolytic activity against human erythrocytes." "[Ref.18584916]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10 ?g/ml), Enterococcus faecalis ATCC 29212 (MIC>80 ?g/ml), Bacillus megaterium (MIC=4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=161 ?g/ml), Escherichia coli ATCC 35218 (MIC>80 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC>161 ?g/ml);##Fungi: Aspergillus flavus (MIC=10 ?g/ml), Candida albicans ATCC 90028 (MIC=20 ?g/ml), Candida parapsilosis ATCC 22019 (MIC=20 ?g/ml), Saccharomyces cerevisiae (MIC=10 ?g/ml)." [Ref:18584916]LC50>80 M against human erythrocytes Linear Free Amidation Free L [Ref.18584916]No cytotoxicity information found Not found 18584916 Peptides. 2008 Sep;29(9):1526-1523. "Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A" "Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica." DRAMP01780 FLSGIVGMLGKLF 13 "Temporin-SHa (Temporin-1Sa; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Pelophylax saharica (North Africa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Bacillus megaterium (MIC=2 ?M);##Gram-negative bacterium: Escherichia coli (MIC=10 ?M).##Yeast: Candida albicans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.31614561]Display cytotoxic against human gastric cells(N87 cell:IC50=1558 324M) Not found 31614561 Biomolecules. 2019 Oct 11;9(10):598. "Olleik H, Baydoun E, Perrier J, Hijazi A, Raymond J, Manzoni M, Dupuis L, Pauleau G, Goudard Y, Villon B, Goin G, Sockeel P, Choudhary MI, Pasquale ED, Nadeem-Ul-Haque M, Ali H, Khan AI, Shaheen F, Maresca M. " Temporin-SHa and Its Analogs as Potential Candidates for the Treatment of Helicobacter pylori. DRAMP01787 AILTTLANWARKFL 14 "Temporin-HN1 (Frogs, amphibians, animals)" E7EKD0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has hemolytic activity against washed human erythrocytes (IC50=75 ?M). "[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=37.5 ?M), Staphylococcus carnosus KHS (MIC=37.5 ?M), Bacillus licheniformis X39 (MIC=19 ?M), Rhodococcus rhodochrous X15 (MIC=4.8 ?M);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=75 ?M);##Fungi: Slime mould 090223 (MIC=19 ?M), Candida albicans ATCC2002 (MIC=75 ?M)." [Ref:22450466]IC50=75 ?M against washed human erythrocytes Linear Free Amidation Free L [Ref.22450466]No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP01788 NILNTIINLAKKIL 14 "Temporin-HN2 (Frogs, amphibians, animals)" E7EKD4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=4.8 ?M), Staphylococcus carnosus KHS (MIC=19 ?M), Bacillus licheniformis X39 (MIC=19 ?M),Rhodococcus rhodochrous X15 (MIC=2.4 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=37.5 ?M).##Fungi: Slime mould 090223 (MIC=9.5 ?M) and Candida albicans ATCC2002 (MIC=9.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.22450466]No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP01789 FLSSIGKILGNLL 13 "Temporin-1Va (Temporin 1Va; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana virgatipes (Ranidae) (Aquarana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: It also has weak hemolytic activty. "[Ref.15996769]Gram-positive bacteria: Staphylococcus aureus NCTC8325 (MIC=10 ?M), S. aureus (MRSA) T7/20 (MIC=20 ?M), S. epidermidis RP62A (MIC=20 ?M), Enterococcus faecalis ATCC 29212 (MIC=40 ?M), Streptococcus group B HNTCC 80130 (MIC=20 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=40 ?M), Klebsiella pneumoniae KK3 9904 (MIC=80 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=160 ?M), Enterobacter cloacae HNTCC 53001 (MIC=40 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=160 ?M)." [Ref:15996769]LD50=120 M against washed human erythrocytes Linear Free Amidation Free L [Ref.15996769]No cytotoxicity information found Not found 15996769 Regul Pept. 2005 Nov;131(1-3):38-45. "Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR." "Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). " DRAMP01807 FLPLVLGALSGILPKIL 17 "Temporin-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=4.69 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa PAO1 (MIC=4.7 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01808 FFPLLFGALSSHLPKLF 17 "Temporin-RN3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=3.75 ?g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa PAO1 (MIC=3.75 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19778602]No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP01818 NFLGTLVNLAKKIL 14 "Temporin-1CSd (Temporin-1DRb; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana cascadae (Cascades frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=64 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.17451843]No cytotoxicity information found Not found 17451843 Peptides 2007; 28: 1268-1274. "Conlon JM, Al-Dhaheri A, Al-Mutawa E, Al-Kharrge R, Ahmed E, Kolodziejek J, Nowotny N, Nielsen PF, Davidson C." Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. DRAMP01391 GCSRWIIGIHGQICRD 16 "Odorranain-U1 (OdU1; Frogs, amphibians, animals)" A6MBS4 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-U1 adopts 60.2% None Function: Odorranain-U1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC>100 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=75.00 g/ml), Bacillus subtilis (MIC=9.37 g/ml).##Yeast: Candida albicans (MIC=9.37 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01844 GIKDWIKGAAKKLIKTVASNIANQ 24 "Ascaphin-5 (Frogs, amphibians, animals)" P0CJ29 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. Tissue specificity: Expressed by the skin glands. "[Ref.15207717]Gram-negative bacteria: Escherichia coli (MIC=6 ?M), Pseudomonas aeruginosa (MIC=13 ?M), Enterobacter cloacae (MIC=6 ?M), Klebsiella pneumoniae (MIC=13 ?M), Proteus mirabilis (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?M), Staphylococcus epidermidis (MIC=13 ?M), Enterococcus faecalis (MIC>100 ?M), Streptococcus Group B (MIC=6 ?M);##Yeast: Candida albicans (MIC=100 ?M)." [Ref.15207717]Not found Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP01849 DSMGAVKLAKLLIDKMKCEVTKAC 24 "Jindongenin-1a (JD1a; Frogs, amphibians, animals)" G3ETQ2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops jingdongensis (Chinese torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Also displays antifungal activity against C. albicans ATCC 2002. Has hemolytic activity, low cytotoxicity and low antioxidant activity." "[Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=17 ?M), Enterococcus faecalis ATCC29212 (MIC=60 ?M), Staphylococcus aureus (IS 10#)(MIC=40 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=10 ?M), Enterobacter cloacae ATCC13047 (MIC=40 ?M), Klebsiella pneumoniae ATCC700603 (MIC=15 ?M), Bacillus pyocyaneus CMCCB1010 (MIC=17 ?M), Pseudomonas aeruginosa ATCC27853 (MIC=23 ?M), Bacillus dysenteriae (MIC=40 ?M);##Yeast: Candida albicans ATCC2002 (MIC=60 ?M)." [Ref.21816202] IC50=150 M against washed human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.21816202] Cytotoxicity: the K562 (IC50=46M)and HT29 mammalian cell lines(IC50=40M). Not found 21816202 Biochimie. 2012 Feb;94(2):328-334. "Chen Z, Yang X, Liu Z, Zeng L, Lee W, Zhang Y." "Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis." DRAMP01869 FFPIIAGMAAKLIPSLFCKITKKC 24 "Brevinin-1SPa (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M);##Yeast: Candida albicans (MIC=7 ?M). [Ref.15556063]HC50=7 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01870 FLPIIAGMAAKVICAITKKC 20 "Brevinin-1SPb (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes (HC50=6 ?M). [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=13 ?M);##Yeast: Candida albicans (MIC=25 ?M). [Ref.15556063]HC50=25 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01872 FFPIIAGMAAKVICAITKKC 20 "Brevinin-1SPd (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=3 ?M);##Yeast: Candida albicans (MIC=8 ?M). [Ref.15556063]HC50=8 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01873 GIWDTIKSMGKVFAGKILQNL 21 "Brevinin-2-related peptide (Frogs, amphibians, animals)" No entry found Not found Not found Rana septentrionalis (mink frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has inhibitory activity towards reference strains of bacteria and an opportunistic yeast pathogen. Also has hemolytic activity against human erythrocytes. Sequence similarity: This peptide shows limited structural similarity with the N-terminal region of brevinin-2 peptides previously isolated from R. temporaria skin but lacks the C-terminal cyclic heptapeptide domain associated with this family. PTM: C-terminal amidation." [Ref.15556063]Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=25 ?M);##Yeast: Candida albicans (MIC=70 ?M). [Ref.15556063]HC50=70 ?M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15556063 Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38. "Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM." Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). DRAMP01748 FFPIVGKRLYGLL 13 "Temporin-AJ8 (Frogs, amphibians, animals)" K7Z903 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops jingdongensis (torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Shows antimicrobial abilities against microorganisms including Gram-negative and Gram-positive bacteria, and fungi. Has hemolytic activity." "[Ref.22828809] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=70 g/ml), B. dysenteriae(MIC=18.75 g/ml) ;## Gram-positive bacteria: Staphylococcus aureus ATCC 2592(MIC=4.7 g/ml), Bacillus subtilis ATCC 6633(MIC=9.38 g/ml);## Yeast: Candida albicans ATCC 2002(MIC=37.5 g/ml)." "[Ref.22828809] 1.79% hemolysis at 25g/ml, 5.22% hemolysis at 50g/ml, 7.92% hemolysis at 100g/ml, 10.85% hemolysis at 200g/ml against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22828809 Amino Acids. 2012 Jul 25. "He X, Yang S, Wei L, Liu R, Lai R, Rong M." "Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis." DRAMP01888 FFPTIAGLTKLFCAITKKC 19 "Brevinin-1CHc (Frogs, amphibians, animals)" No entry found Not found Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: E. coli (MIC=80 ?M);##Gram-positive bacterium: S. aureus (MIC=20 ?M).##Yeast: C. albicans (MIC=20 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys13 and Cys19) Disulfide bond between Cys13 and Cys19. L No cytotoxicity information found Not found 21262304 Peptides. 2011 Apr;32(4):664-669. "Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01889 GIGSILGVIAKGLPTLISWIKNR 23 "Brevinin-1TOa (Frogs, amphibians, animals)" No entry found Not found Not found Rana tagoi okiensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: E. coli (MIC=20 ?M);##Gram-positive bacterium: S. aureus (MIC=5 ?M).##Yeast: C. albicans (MIC=20 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19799928 Toxicon. 2010 Feb-Mar;55(2-3):430-435. "Conlon JM, Coquet L, Jouenne T, Leprince J, Vaudry H, Iwamuro S." Evidence from the primary structures of dermal antimicrobial peptides that Rana tagoi okiensis and Rana tagoi tagoi (Ranidae) are not conspecific subspecies. DRAMP01890 FLGAIAGVAAKFLPKVFCFITKKC 24 "Brevinin-1VLa (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Brevinin-1VLa showes particularly high growth-inhibitory potency (MIC < or =3 microM) against a Gram-positive microorganism Staphylococcus aureus and the opportunistic yeast pathogen Candida albicans and potent cytolytic activity (LC(50)< or =8 microM) against both human erythrocytes and HepG2 hepatoma-derived cells. The peptide ia also active against a Gram-negative microorganism Escherichia coli (MIC< or =50 microM). Gram-negative bacterium: E. coli (MIC=25 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=8 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01891 FLPVIASVAAKVLPKVFCFITKKC 24 "Brevinin-1VLc (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Brevinin-1VLc showes particularly high growth-inhibitory potency (MIC < or =3 microM) against a Gram-positive microorganism Staphylococcus aureus and the opportunistic yeast pathogen Candida albicans and potent cytolytic activity (LC(50)< or =8 microM) against both human erythrocytes and HepG2 hepatoma-derived cells. The peptide ia also active against a Gram-negative microorganism Escherichia coli (MIC< or =50 microM). Gram-negative bacterium: E. coli (MIC=50 ?M);##Gram-positive bacterium: S. aureus (MIC=1.5 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=7 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=4mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01892 FLPLIAGVAANFLPKIFCLISKKC 24 "Brevinin-1VLd (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells" Gram-negative bacterium: E. coli (MIC>100 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=5 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=6mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01893 FLPLIAGVAASILPKIFCFITKKC 24 "Brevinin-1VLe (Frogs, amphibians, animals)" No entry found Not found Not found Rana vaillanti (Central American frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits the growth of reference strains of S. aureus, E. coli and C. albicans and to lyse human erythrocytes from a healthy donor and HepG2 human hepatoma-derived cells" Gram-negative bacterium: E. coli (MIC>100 ?M);##Gram-positive bacterium: S. aureus (MIC=3 ?M).##Yeast: C. albicans (MIC=3 ?M). [Ref.19379837] LC50=5 mM against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L [Ref.19379837] LC50=7mM against HepG2 hepatoma-derived cells Not found 19379837 Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):150-154. "Conlon JM, Raza H, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)." DRAMP01896 FLSTALKVAANVVPTLFCKITKKC 24 "Brevinin-1CG1 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=9 ?M), Bacillus licheniformis X39 (IS) (MIC=75 ?M);##Gram-negative bacterium: Escherichia coli (ATCC 25922) (MIC=150 ?M).##Fungi: Slime mold 090223 (IS) (MIC=75 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01897 FLPIVAGLAANFLPKIVCKITKKC 24 "Brevinin-1CG2 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=9 ?M), Bacillus licheniformis X39 (IS) (MIC=75 ?M), Enterococcus faecalis 981 (MIC=19 ?M), Staphylococcus carnosus KHS (IS) (MIC=9 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=19 ?M), Serratia rubidaea X01 (IS) (MIC=19 ?M).##Fungi: Slime mold 090223 (IS) (MIC=4.5 ?M), Candida albicans (ATCC 10231) (MIC=150 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01898 FLSTLLNVASNVVPTLICKITKKC 24 "Brevinin-1CG3 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Primarily active against Gram-positive bacteria. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea. "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=2.3 ?M), Bacillus licheniformis X39 (IS) (MIC=9 ?M), Enterococcus faecalis 981 (MIC=75 ?M), Staphylococcus carnosus KHS (IS) (MIC=19 ?M), Staphylococcus aureus (ATCC 25923) (MIC=19 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=4.5 ?M), Serratia rubidaea X01 (IS) (MIC=9 ?M).##Fungi: Slime mold 090223 (IS) (MIC=9 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01899 FLSTLLNVASKVVPTLFCKITKKC 24 "Brevinin-1CG4 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=2.3 ?M), Bacillus licheniformis X39 (IS) (MIC=9 ?M), Enterococcus faecalis 981 (MIC=9 ?M), Staphylococcus carnosus KHS (IS) (MIC=9 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli (ATCC 25922) (MIC=150 ?M), Pseudomonas aeruginosa 11053 (IS) (MIC=75 ?M), Psychrobacter faecalis X29 (IS) (MIC=9 ?M), Serratia rubidaea X01 (IS) (MIC=9 ?M).##Fungi: Slime mold 090223 (IS) (MIC=9 ?M), Candida albicans (ATCC 10231) (MIC=150 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01900 FLPMLAGLAANFLPKIVCKITKKC 24 "Brevinin-1CG5 (Frogs, amphibians, animals)" No entry found Not found Not found Amolops chunganensis (Chungan torrent frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Primarily active against Gram-positive bacteria, escecially R. rhodochrous. Also highly active against Gram-negative P. faecalis X29 and S. rubidaea." "Gram-positive bacteria: Rhodococcus rhodochrous X15 (MIC=0.6 ?M), Bacillus licheniformis X39 (IS) (MIC=2.3 ?M), Enterococcus faecalis 981 (MIC=9 ?M), Staphylococcus carnosus KHS (IS) (MIC=1.2 ?M), Staphylococcus aureus (ATCC 25923) (MIC=9 ?M);##Gram-negative bacteria: Escherichia coli (ATCC 25922) (MIC=75 ?M), Pseudomonas aeruginosa (CGMCC 1.50) (MIC=75 ?M), Pseudomonas aeruginosa 11053 (IS) (MIC=75 ?M), Klebsiella pneumoniae 08040724 (IS) (MIC=150 ?M), Psychrobacter faecalis X29 (IS) (MIC=9 ?M), Serratia rubidaea X01 (IS) (MIC=4.6 ?M).##Fungi: Slime mold 090223 (IS) (MIC=4.5 ?M), Candida albicans (ATCC 10231) (MIC=437.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22951323 Peptides. 2012 Nov;38(1):41-53. "Yang X, Xia J, Yu Z, Hu Y, Li F, Meng H, Yang S, Liu J, Wang H." Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis. DRAMP01914 GLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC 33 "Brevinin-2GRa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grahami (Asian frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M).##Yeast: Candida albicans (MIC>100 ?M). [Ref.16621155] LC50=140 M against human erythrocytes. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16621155##17272268 Peptides. 2006 Sep;27(9):2111-2117.##Mol Cell Proteomics. 2007 May;6(5):882-894. "Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H.##Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." "Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami.##Anti-infection peptidomics of amphibian skin." DRAMP01918 FLPLIAGLAANFLPKIFCAITKKC 24 "Brevinin-1PLb (Frogs, amphibians, animals)" A7WNV3 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity. Tissue specificity: Expressed by the skin glands." Gram-positive bacterium: Staphylococcus aureus (MIC=9 ?M);##Gram-negative bacterium: Escherichia coli(MIC=26 ?M).##Yeast: Candida albicans (MIC=6 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17698247##11087945 Peptides. 2007 Aug;28(8):1605-1610.##Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Zhou M, Wang L, Owens DE, Chen T, Walker B, Shaw C.##Basir YJ, Knoop FC, Dulka J, Conlon JM." "Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step shotgun cloning.##Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01919 FLPVIAGVAAKFLPKIFCAITKKC 24 "Brevinin-1PLc (Frogs, amphibians, animals)" A7WNV4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (Pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli(MIC=7 ?M).##Yeast: Candida albicans (MIC=8 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17698247##11087945 Peptides. 2007 Aug;28(8):1605-1610.##Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Zhou M, Wang L, Owens DE, Chen T, Walker B, Shaw C.##Basir YJ, Knoop FC, Dulka J, Conlon JM." "Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step shotgun cloning.##Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP01940 FLPIIAGVAAKVLPKLFCAITKKC 24 "Brevinin-1CHa (Frogs, amphibians, animals)" A7YJE2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None PTM: Contains disulfide bond. "Gram-negative bacteria: E. coli (MIC=10 ?M), K. pneumoniae (MIC=40 ?M), P. aeruginosa (MIC=20 ?M);##Gram-positive bacterium: S. aureus (MIC=2.5 ?M).##Yeast: C. albicans (MIC=2.5 ?M).(Ref.2)" [Ref.21262304] LC50=5 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 17938991##21262304 J Mol Evol. 2007 Nov;65(5):605-615.##Peptides. 2011 Apr;32(4):664-669. "Tennessen JA, Blouin MS.##Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.##Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01941 FLPVIAGLAAKVLPKLFCAITKKC 24 "Brevinin-1CHb (Frogs, amphibians, animals)" A7YJE4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana chiricahuensis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None PTM: Contains disulfide bond. "Gram-negative bacteria: E. coli (MIC=10 ?M), K. pneumoniae (MIC=40 ?M), P. aeruginosa (MIC=10 ?M);##Gram-positive bacterium: S. aureus (MIC=2.5 ?M).##Yeast: C. albicans (MIC=2.5 ?M).(Ref.2)" [Ref.21262304] LC50=5 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 17938991##21262304 J Mol Evol. 2007 Nov;65(5):605-615.##Peptides. 2011 Apr;32(4):664-669. "Tennessen JA, Blouin MS.##Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD." Selection for antimicrobial peptide diversity in frogs leads to gene duplication and low allelic variation.##Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona. DRAMP01963 FLPAIVGAAAKFLPKIFCAISKKC 24 "Brevinin-1BLa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates blairi (plains leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus" [Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=1.5 M);##Gram-negative bacteria : Escherichia coli(MIC=25 M);##Fungi : Candida albicans(MIC=6 M) [Ref.19254736] LC50=14 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01965 FLPIIAGIAAKFLPKIFCTISKKC 24 "Brevinin-1BLc (Frogs, amphibians, animals)" B6CPR0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates blairi (leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans [Ref.19254736]Gram-negative bacterium:?Escherichia coli (MIC=25 ?M);##Gram-positive bacterium:?Staphylococcus aureus (MIC=1.5 ?M);##Yeast:?Candida albicans (MIC=3 ?M);##Cancer cells HepG2:?(LC50=6 ?M).. [Ref.19254736] LC50=9 M against human red blood cells.##[Ref.14531844]Non-hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01968 FLPIIAGAAAKVVEKIFCAISKKC 24 "Brevinin-1Yc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates yavapaiensis (North American leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans [Ref.19254736] Gram-positive bacteria : Staphylococcus aureus(MIC=6 M);##Gram-negative bacteria : Escherichia coli(MIC=100 M);##Fungi : Candida albicans(MIC=6 M)Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M).##Yeast: Candida albicans (MIC=6 ?M).##cancer cells HepG2 (LC50=14 ?M). [Ref.19254736] LC50=13 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP01970 FLPFLLSALPKVFCFFSKKC 20 "Brevinin-1ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=32 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>43 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01971 FLPLLLSALPSFLCLVFKKC 20 "Brevinin-1ZHb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=33 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC>44 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>44 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01974 GIMRVFKGVLKTAGKSVAKNVAGSFLDRLKCKISGGC 37 "Brevinin-2ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=5 ?M).##Yeast: Candida albicans ATCC 2002 (MIC=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP01986 SLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC 33 "Brevinin-2HS2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Huia schmackeri (Chinese piebald odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: It shows poor hemolycity activity (LC50=300 uM). "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 ?M), Bacillus licheniformis X39 (MIC=39 ?M), Rhodococcus rhodochrous X15 (MIC=9.5 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 ?M).##Fungi: Slime mould 090223 (MIC=37.5 ?M), Candida albicans ATCC2002 (MIC=19 ?M)." LC50=300?M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 18423796 Peptides. 2008 Aug;29(8):1456-1460. "Quan Z, Zhou M, Chen W, Chen T, Walker B, Shaw C." Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors. DRAMP01995 SFLTTFKDLAIKAAKSAGQSVLSTLSCKLSNTC 33 "Brevinin-2ISb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana ishikawae (Endangered frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), Bacillus subtilis (MIC=25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21193000 Peptides. 2011 Apr;32(4):670-676. "Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M." Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae. DRAMP02001 FLPLIASLAANFVPKIFCKITKKC 24 "Brevinin-1HN1 (Frogs, amphibians, animals)" E7EKC4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Hainan odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P. faecalis. Has hemolytic activity against human erythrocytes (LC50=75 ?M). Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond." "[Ref.22450466]Gram-positive bacteria: Enterococcus faecium 091299 (MIC=19 ?M), Enterococcus faecalis 981 (MIC=19 ?M), Staphylococcus aureus ATCC2592 (MIC=1.2 ?M), Staphylococcus carnosus KHS (MIC=4.8 ?M), Bacillus licheniformis X39 (MIC=2.4 ?M), Rhodococcus rhodochrous X15 (MIC=1.2 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=150 ?M), Psychrobacter faecalis X29 (MIC=4.8 ?M);##Fungi: Slime mould 090223 (MIC=1.2 ?M), Candida albicans ATCC2002 (MIC=2.4 ?M)." [Ref.22450466] LC50=75 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP02004 FLPLIASVAANLVPKIFCKITKKC 24 "Brevinin-1V (Frogs, amphibians, animals)" "Q2UXV8, E7EKC5" Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana versabilis (Chinese bamboo leaf odorous frog) (Rana versabilis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P. faecalis. Has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond." "[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=19 ?M), Bacillus licheniformis X39 (MIC=37.5 ?M), Rhodococcus rhodochrous X15 (MIC=9.5 ?M), Enterococcus faecium 091299 (MIC=19 ?M), E. faecalis 981 (MIC=19 ?M);##Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=9.5 ?M);##Fungi: Slime mould 090223 (MIC=1.2 ?M), Candida albicans ATCC2002 (MIC=19-37.5 ?M)." [Ref.22450466] LC50=75 ?M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 16139929##22450466 Peptides. 2006 Jan;27(1):42-48.##Peptides. 2012 Jun;35(2):285-290. "Chen T, Li L, Zhou M, Rao P, Walker B, Shaw C.##Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Amphibian skin peptides and their corresponding cDNAs from single lyophilized secretion samples: identification of novel brevinins from three species of Chinese frogs.##Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP18380 SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAQRVGAGAPVY 50 Acipensin 1 (Ac1) No entry found Not found Not found "Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii" "Antimicrobial, Antibacterial, Antifungal" Not found Not found None Comment: No comments found on DRAMP database "Active against E. coli ML35p (MIC 0.7 uM), L. monocytogenes EGD (MIC 1.1 uM), MRSA ATCC 33591 (MIC 0.9 uM), C. albicans 820 (MIC 1 uM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 25558400 Acta Naturae. 2014 Oct;6(4):99-109 "Shamova OV, Orlov DS, Balandin SV, Shramova EI, Tsvetkova EV, Panteleev PV, Leonova YF, Tagaev AA, Kokryakov VN, Ovchinnikova TV." Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii DRAMP18379 SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLR 35 Acipensin 2 (Ac2) No entry found Not found Not found "Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii" "Antimicrobial, Antibacterial, Antifungal" Not found Not found None Comment: No comments found on DRAMP database "Active against E. coli ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), C. albicans 820 (MIC 0.9 uM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 25558400 Acta Naturae. 2014 Oct;6(4):99-109. "Shamova OV, Orlov DS, Balandin SV, Shramova EI, Tsvetkova EV, Panteleev PV, Leonova YF, Tagaev AA, Kokryakov VN, Ovchinnikova TV." Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii. DRAMP02032 FLGSIVGALASALPSLISKIRN 22 "Brevinin-1TSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tsushimensis (Tsushima brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, but hemolytic activity against human erythrocytes." "[Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=25 ?M), Klebsiella pneumoniae KK3 9904 (MIC>100 ?M), Enterobacter cloacae HNTCC 53001 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=50 ?M), Proteus mirabilis ATCC 25933 (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=25 ?M), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 ?M), Staphylococcus epidermidis RP62A (MIC=12.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=50 ?M), Streptococcus group B HNTCC 80130 (MIC=50 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=50 ?M)" [Ref.16413829]LD50=12 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16413829 Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. "Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. DRAMP02033 GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC 33 "Brevinin-2TSa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana tsushimensis (Tsushima brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, but relatively low hemolytic activity against human erythrocytes." "[Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 ?M), Klebsiella pneumoniae KK3 9904 (MIC=6 ?M), Enterobacter cloacae HNTCC 53001 (MIC=6 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=6 ?M), Proteus mirabilis ATCC 25933 (MIC>100 ?M);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=12.5 ?M), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 ?M), Staphylococcus epidermidis RP62A (MIC=12.5 ?M), Enterococcus faecalis ATCC 29212 (MIC=25 ?M);##Yeast: Candida albicans ATCC 90028 (MIC=100 ?M)." [Ref.16413829] LD50=100 M against human erythrocytes Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16413829 Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):42-49. "Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S." Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. DRAMP02034 FLPILAGLAAKLVPKVFCSITKKC 24 "Brevinin-1AUa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana aurora aurora (Northern red-legged frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and also shows hemolytic. " "[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=13 ?M), Pseudomonas aeruginosa (MIC=25 ?M), Enterobacter cloacae (MIC=13 ?M), Klebsiella pneumoniae (MIC=50 ?M), Proteus mirabilis (MIC>50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Staphylococcus epidermidis (MIC=6 ?M), Enterococcus faecalis (MIC=13 ?M), Streptococcus Group B (MIC=13 ?M);##Yeast: Candida albicans (MIC>40 ?M)." [Ref.15325526] HC50=5 M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 15325526 Dev Comp Immunol. 2005;29(1):83-90. "Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T." Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. DRAMP02035 FLPILAGLAANILPKVFCSITKKC 24 "Brevinin-1AUb (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana aurora aurora (Northern red-legged frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Activity against a range of Gram-positive and Gram-negative bacteria, and also shows hemolytic activity. " "[Ref.15325526]Gram-negative bacteria: Escherichia coli (MIC=25 ?M), Pseudomonas aeruginosa (MIC=25 ?M), Enterobacter cloacae (MIC=25 ?M), Klebsiella pneumoniae (MIC>50 ?M), Proteus mirabilis (MIC>50 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?M), Staphylococcus epidermidis (MIC=6 ?M), Enterococcus faecalis (MIC=6 ?M), Streptococcus Group B (MIC=13 ?M);##Yeast: Candida albicans (MIC=3 ?M)." [Ref.15325526] HC50=7 M against human erythrocytes Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 15325526 Dev Comp Immunol. 2005;29(1):83-90. "Conlon JM, Sonnevend A, Davidson C, Demandt A, Jouenne T." Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. DRAMP02036 GAFGNFLKGVAKKAGLKILSIAQCKLSGTC 30 "Brevinin-2-RN1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Brevinin-2-RN1 and -RN2 could induce 17 and 21% Rabbit red blood cell hemolysis, respectively." "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=3.10 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=3.10 ?g/ml), Bacillus subtilis (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=25 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=6.25 ?g/ml)." [Ref.21171145] It has 17% hemolysis at 100 ?g/ml against rabbit red blood cell Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 21171145 J Pept Sci. 2011 Jan;17(1):68-72. "Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R." "Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata." DRAMP02037 GAFGNFLKGVAKKAGLKILSIAQCKLFGTC 30 "Brevinin-2-RN2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Brevinin-2-RN1 and -RN2 could induce 17 and 21% Rabbit red blood cell hemolysis, respectively." "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=6.25 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 ?g/ml), Bacillus subtilis (MIC=12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35P (MIC=50 ?g/ml), Pseudomonas aeruginosa PA01 (MIC=12.5 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=12.5 ?g/ml). Yeast: Candida albicans ATCC2002 (MIC=3.1 ?g/m)." [Ref.21171145] It has 21% hemolysis at 100 ?g/ml against rabbit red blood cell Cyclic Free Cyclization (Cys24 and Cys30) Disulfide bond between Cys24 and Cys30. L No cytotoxicity information found Not found 21171145 J Pept Sci. 2011 Jan;17(1):68-72. "Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R." "Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata." DRAMP02038 VIVFVASVAAEMMQHVYCAASKKC 24 "Brevinin-1-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 ?g/ml);##Gram-negative bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml), Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml).##Yeast: Candida albicans (MIC=24.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02040 FLPAVIRVAANVLPTAFCAISKKC 24 "Brevinin-1-OA12 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.2 ?g/ml).##Yeast: Candida albicans (MIC=3.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02041 LPFVAGVAAEMMQHVYCAASKKC 23 "Brevinin-1-OR1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=42.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.6 ?g/ml).##Yeast: Candida albicans (MIC=10.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys17 and Cys23) Disulfide bond between Cys17 and Cys23. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02042 IDPFVAGVAAEMMQHVYCAASKKC 24 "Brevinin-1-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=9.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=18.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=18.2 ?g/ml).##Yeast: Candida albicans (MIC=18.2 ?g/ml). " [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02043 INPFVAGVAAEMMQHVYCAASKKC 24 "Brevinin-1-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml).##Yeast: Candida albicans (MIC=8.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02044 ILPFVAGVAAEMMKHVYCAASKKC 24 "Brevinin-1-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None It differs from AP1824 only at position 14: Q vs. K. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.2 ?g/ml).##Yeast: Candida albicans (MIC=7.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02045 IIPFVAGVAAEMMEHVYCAASKKC 24 "Brevinin-1-OR6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None It differs from AP1827 at two positions: 2: I vs. L and 14: K vs. E. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.2 ?g/ml).##Yeast: Candida albicans (MIC=11.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02046 QLPFVAGVACEMCQCVYCAASKKC 24 "Brevinin-1-OR7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=5.7 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.4 ?g/ml).##Yeast: Candida albicans (MIC=11.4 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02047 ILPFVAGVAAEMMEHVYCAASKKC 24 "Brevinin-1-OR8 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=52.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=26.2 ?g/ml).##Yeast: Candida albicans (MIC=13.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02048 ILPFVAGVAAMEMEHVYCAASKKC 24 "Brevinin-1-OR9 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=9.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=9.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.9 ?g/ml).##Yeast: Candida albicans (MIC=9.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02049 FLPAVLLVATHVLPTVFCAITRKC 24 "Brevinin-1-OR10 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=27.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.8 ?g/ml).##Yeast: Candida albicans (MIC=6.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02050 LAFVAGVAAEMMQHVYCAASKKC 23 "Brevinin-1-OR11 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.4 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.4 ?g/ml).##Yeast: Candida albicans (MIC=12.4 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys17 and Cys23) Disulfide bond between Cys17 and Cys23. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02051 ILPFVAGVAAEMMQHVYCAASKKC 24 "Lividin-1 (Brevinin-1-OR2; Frogs, amphibians, animals)" Q2UXR4 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-1 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 ?g/ml).##Yeast: Candida albicans (MIC=5.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02052 SFLDTLKNLAISAAKGAGQSVLSTLSCKLSKTC 33 "Lividin-2 (Brevinin-2-OR8; Frogs, amphibians, animals)" Q2UXR3 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-2 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=13.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=13.1 ?g/ml).##Yeast: Candida albicans (MIC=13.1 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02053 SVLGTVKDLLIGAGKSAAQSVLTALSCKLSNSC 33 "Lividin-3 (Brevinin-2-OR1; Frogs, amphibians, animals)" Q2UXR2 Belongs to the frog skin active peptide family (Brevinin subfamily) lividin-3 Odorrana rotodora (Chinese odorous frog) (Odorrana livida) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Amphibian defensive peptide. Tissue specificity: Expressed by the skin glands. PTM: Contains disulfide bond." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=22 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11 ?g/ml).##Yeast: Candida albicans (MIC=11 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 16713657##22029824 Peptides. 2006 Sep;27(9):2118-2123.##J Proteome Res. 2012 Jan 1;11(1):306-319. "Zhou M, Chen T, Walker B, Shaw C.##Yang X, Lee WH, Zhang Y." "Lividins: novel antimicrobial peptide homologs from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida. Identification by shotgun cDNA cloning and sequence analysis.##Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs." DRAMP02054 GILDTFKNMALNAAKSAGVSVLNALSCKLSKTC 33 "Brevinin-2-OA1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.1 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.1 ?g/ml).##Yeast: Candida albicans (MIC=6.0 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02055 GLLDTFKNMALNAAKSAGVSVLNALSCKLSKTC 33 "Brevinin-2-OA2 (Brevinin-2E-OG1; Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Found in multiple species. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml).##Yeast: Candida albicans (MIC=6.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02056 GLLDTFKNMAINAAHGAGVSVLNALSCKLKKTC 33 "Brevinin-2-OA3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=12.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 ?g/ml).##Yeast: Candida albicans (MIC=3.2 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02057 GLLDTFKNLAINAAESAGVSVLNSLSCKLSKTC 33 "Brevinin-2-OA4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=10 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02058 GLLDGILNANFNAAKSAGTSVLNALSCKLSKTC 33 "Brevinin-2-OA5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=30.6 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=30.6 ?g/ml).##Yeast: Candida albicans (MIC=30.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02059 GVLATVKNLLIGTGDGAAQSVLKTLSCKLSNDC 33 "Brevinin-2-OA6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=44.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=22.4 ?g/ml).##Yeast: Candida albicans (MIC=11.2 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02060 GVLGTVKDLLIGAGKSAAQSTLKTLSCKISNDC 33 "Brevinin-2-OA7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=23.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=11.6 ?g/ml).##Yeast: Candida albicans (MIC=5.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02061 GVLATVKNLLNGTGDGAAQSVLKTLSCKLSNDC 33 "Brevinin-2-OA8 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana andersonii (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.9 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=4.0 ?g/ml).##Yeast: Candida albicans (MIC=4.0 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02062 GLLDTIKNMALNAAKSAGVSVLNSLSCKLSKTC 33 "Brevinin-2-OR2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.0 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12.1 ?g/ml).##Yeast: Candida albicans (MIC=12.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02063 GLIDTIKNMALNAAKSAGVSVLNTLSCKLSKTC 33 "Brevinin-2-OR3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=41.2 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=20.6 ?g/ml).##Yeast: Candida albicans (MIC=10.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02064 SVLGTVKDLLIGAGKSAAQSVLTANSCKLSNSC 33 "Brevinin-2-OR4 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=11.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.8 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=5.9 ?g/ml).##Yeast: Candida albicans (MIC=11.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02065 SFLDTLKNLAISAAKGAGQSVLSTLSCKLSETC 33 "Brevinin-2-OR5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6.6 ?g/ml).##Fungi: Candida albicans (MIC=6.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02066 GLLDTIKNMALNAAKSAGVSVLNSLSCKDSKTC 33 "Brevinin-2-OR6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=5.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=11.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=5.8 ?g/ml).##Fungi: Candida albicans (MIC=11.6 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02067 GLLDTIKNMALNAAKSAGVSVLNTLSCKLSKTC 33 "Brevinin-2-OR7 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 ?g/ml).##Fungi: Candida albicans (MIC=17.2 ?g/ml)" [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02068 SFLSTFKELAINAAKNAGQSILHTLSCKLDKTC 33 "Brevinin-2-OR9 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=20.4 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=20.4 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=10.2 ?g/ml).##Fungi: Candida albicans (MIC=5.1 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02069 SFLSTFKELAINAAKNAGQSLLHTLSCKLDKTC 33 "Brevinin-2-OR10 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana rotodora (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: It differs from AP1850 only at position 21: L vs. I, so they are predicted to have essentially identical structure and activity." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.8 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=7.9 ?g/ml).##Fungi: Candida albicans (MIC=15.8 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02070 SVMGTVKDLLIGAGKSAAQSVLKSLSCKISNDC 33 "Brevinin-2-OW1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.7 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=9.4 ?g/ml).##Fungi: Candida albicans (MIC=4.7 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02071 SVMGTVKDLLIGAGKSAAQSVLKSLSCKLSNDC 33 "Brevinin-2-OW2 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.6 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.3 ?g/ml).##Fungi: Candida albicans (MIC=3.3 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02072 SVMGTVKDLLIGAGKSAAQSVLKALSCKLSKDC 33 "Brevinin-2-OW3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana wuchuanensis (Chinese odorous frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=21.0 ?g/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=10.5 ?g/ml).##Fungi: Candida albicans (MIC=10.5 ?g/ml)." [Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 g/mL. Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 22029824 J Proteome Res. 2012 Jan 1;11(1):306-319. "Yang X, Lee WH, Zhang Y." Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. DRAMP02073 FLPAVIRVAANVLPTVFCAISKKC 24 "Brevinin-1JDa (Frogs, amphibians, animals)" B3A0M4 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Has hemolytic activity against rabbit erythrocytes. Tissue specificity: Expressed by the skin glands. PTM: contains one disulfide bonds." "[Ref.22917879]Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), S. aureus (MRSA) (MIC=32 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=128 ?g/ml);##Fungi: Candida albicans (MIC=128 ?g/ml)." [Ref.22917879] It has 79.2 6.8% hemolytic activity at 128 g/mL against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 22917879 J Proteomics. 2012 Oct 22;75(18):5807-5821. "Liu J, Jiang J, Wu Z, Xie F." "Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data." DRAMP02084 GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC 33 "Brevinin-2E (Frogs, amphibians, animals)" P32413 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity." "[Ref.8508915]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=0.2 ?M), Staphylococcus aureus Cowan 1 (MIC=2.0 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 ?M), Pseudomonas aeruginosa ATCC 15692 (MIC>30 ?M)." [Ref.8163497]LC50>100 M against human red blood cells Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 8508915 FEBS Lett. 1993 Jun 14;324(2):159-161. "Simmaco M, Mignogna G, Barra D, Bossa F." Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. DRAMP02104 GLMSTLKDFGKTAAKEIAQSLLSTASCKLAKTC 33 "Brevinin-2RTa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Amolops ricketti (Chinese sucker frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Brevinin-2RTb has antibacterial activity and hemolytic activity against rabbit red blood cells in vitro. PTM: Contains one disulfide bond 27-33." "[Ref.22100518]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=12.5 ?g/ml), Bacillus licheniformis X39 (MIC=50.0 ?g/ml), Staphylococcus carnosus KHS (MIC=6.3 ?g/ml), Rhodococcus rhodochrous X15 (MIC=1.6 ?g/ml);##Gram-negative bacteria: Serratia rubidaea X01 (MIC=100.0 ?g/ml), Psychrobacter faecalis X29 (MIC=6.3 ?g/ml)." [Ref.22100518]LD50>400 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22100518 Peptides. 2012 Jan;33(1):27-34. "Wang H, Ran R, Yu H, Yu Z, Hu Y, Zheng H, Wang D, Yang F, Liu R, Liu J." Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). DRAMP02125 IFGAILPLALGALKNLIK 18 "Hylin-a1 (Hy-a1; Frogs, amphibians, animals)" P85982 Not found Not found Hypsiboas albopunctatus (Spotted tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found 2N0O resolved by NMR. "Function: Has antibacterial activity against the Gram-positive bacteria and the Gram-negative bacteria. Has hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.19056441]Gram-positive bacteria: Staphylococcus aureus ATCC 25926 (MIC=8 ?M), Enterococcus faecalis ATCC 29212 (MIC=16 ?M), Bacillus subtilis ATCC 19659 (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=32 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=64 ?M);##Fungi: Candida albicans ATCC 90028 (MIC=16.7 ?M), C. krusei ATCC 6258 (MIC=16.7 ?M), C. parapsilosis ATCC 22019 (MIC=67 ?M), Cryptococcus neoformans ATCC 90012 (MIC=33.5 ?M)" [Ref.19056441]HC50=18 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19056441 Peptides. 2009 Feb;30(2):291-296. "Castro MS, Ferreira TC, Cilli EM, Crusca E Jr, Mendes-Giannini MJ, Sebben A, Ricart CA, Sousa MV, Fontes W." "Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus (spotted treefrog)." DRAMP02128 FLGGILNTITGLL 13 "Kassorin-S (PreproKassorin-S; Frogs, amphibians, animals)" E6ZBE2 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Kassina senegalensis (Senegal running frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide. Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Lacks ability to induce contraction of smooth muscle in isolated guinea pig urinary bladder. Elicits histamine release from rat peritoneal mast cells. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." Gram-positive bacterium: Staphylococcus aureus (MIC=30 ?M).##Yeast: Candida albicans (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21040978 Mol Immunol. 2011 Jan;48(4):442-451. "Chen H, Wang L, Zeller M, Hornshaw M, Wu Y, Zhou M, Li J, Hang X, Cai J, Chen T, Shaw C." "Kassorins: novel innate immune system peptides from skin secretions of the African hyperoliid frogs, Kassina maculata and Kassina senegalensis." DRAMP02130 GFLGPLLKLAAKGVAKVIPHLIPSRQQ 27 "Antimicrobial peptide 1 (XT-1; Frogs, amphibians, animals)" P84387 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E.coli and stronger activity against yeast C. albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells . Tissue specificity: Expressed by the skin glands." [Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacteria: Escherichia coli (MIC=6 ?M);##Fungi: Candida albicans (MIC=50 ?M) [Ref.11738090]HC50=90 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02133 GVFLDALKKFAKGGMNAVLNPK 22 "Antimicrobial peptide 4 (XT-4; Frogs, amphibians, animals)" P84384 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and yeast C. albicans, and very weak activity against Gram-negative bacterium E.coli. Has strong hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." [Ref.11738090]Gram-positive bacteria: Staphylococcus aureus (MIC>100 ?M);##Gram-negative bacteria: Escherichia coli (MIC=18 ?M);##Fungi: Candida albicans (MIC>100 ?M). [Ref.11738090]HC50>150 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02135 GFLGSLLKTGLKVGSNLL 18 "Antimicrobial peptide 6 (XT-6; Frogs, amphibians, animals)" P84386 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against Gram-positive bacterium S. aureus and Gram-negative bacterium E.coli and strong activity against yeast C. albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells. Tissue specificity: Expressed by the skin glands." "[Ref.11738090]Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=5 ?M);##Yeast: Candida albicans (MIC=40 ?M);##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 ?M), Staphylococcus aureus (MRSA) (MIC=7 ?M), Staphylococcus epidermidis 1420129 (MIC=3 ?M), S. saprophyticus 1950556 (MIC=13 ?M), Escherichia coli 25922 (MIC=6 ?M), Streptococcus group C 1541035 (MIC=3 ?M), Shigella sonnei 1840187 (MIC=35 ?M), Pseudomonas aeruginosa 0380972 (MIC=60 ?M), Enterobacter cloacae 1441323 (MIC=35 ?M)" [Ref.11738090]HC50=70 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02136 GLLGPLLKIAAKVGSNLL 18 "Antimicrobial peptide 7 (XT-7; Frogs, amphibians, animals)" P84381 Not found Not found Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has very strong antibacterial activity against many Gram-negative bacteria and the Gram-positive bacteria S.pneumoniae and Enterococcus sp. There is moderate antimicrobial activity against the Gram-negative bacterium P.aeruginosa and yeast C. albicans and weaker activity against the Streptococcal strains and E.coli. Has hemolytic activity against human red blood cells (HC50=70 ?M). Seems to disrupt the membranes by adopting an alpha-helical conformation. Tissue specificity: Expressed by the skin glands. PTM: Amidation on Leu-18 is required to adopt an alpha-helical conformation in a hydrophobic solvent. The absence of amidation leads to a decrease in cationicity leading to a more than a 10-fold decrease in antimicrobial activities." "Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M);##Gram-negative bacterium: Escherichia coli (MIC=5 ?M);##yeast Candida albicans (MIC=40 ?M).##Clinical isolates: Staphylococcus aureus 8325 (MIC=6 ?M), Staphylococcus aureus (MRSA) (MIC=7 ?M), Staphylococcus epidermidis 1420129 (MIC=3 ?M), S. saprophyticus 1950556 (MIC=13 ?M), Escherichia coli 25922 (MIC=6 ?M), Streptococcus group C 1541035 (MIC=3 ?M), Shigella sonnei 1840187 (MIC=35 ?M), Pseudomonas aeruginosa 0380972 (MIC=60 ?M), Enterobacter cloacae 1441323 (MIC=35 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11738090 Biochim Biophys Acta. 2001 Nov 26;1550(1):81-89. "Ali MF, Soto A, Knoop FC, Conlon JM." "Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)." DRAMP02222 GLLDTIKNTAKNLAVGLLDKIKCKMTGC 28 "Ranatuerin-2PLc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=3 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02223 GIMDSVKNVAKNIAGQLLDKLKCKITGC 28 "Ranatuerin-2PLd (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP02225 GIMDTVKNAAKDLAGQLDKLKCRITGC 27 "Ranatuerin-2PLf (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana palustris (North America pickerel frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: May have antimicrobial activity against the Gram-negative bacterium E. coli. Tissue specificity: Expressed by the skin glands." Gram-negative bacterium: Escherichia coli (MIC=23 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11087945 Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. "Basir YJ, Knoop FC, Dulka J, Conlon JM." "Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris." DRAMP18494 FIHHIIGGLFSAGKAIHRLIRRRRR 25 TP4 L0CKG3 Piscidin TP4 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) "Antibacterial, Antifungal, anticancer, wound healing, Anti-Gram+, Anti-Gram-, Antimicrobial" Protein level Alpha helix "1.0x sarkosyl can drive TP4 into a conformational change from a non-structure to an alpha-helical structure, and that LPS can also drive TP4 to an alpha-helical structure but with high hydrophobicity and low solubility." 5H2S Function: Antibacterial activity against the Gram-positive and Gram-negative bacteria. Antifungal activity. Has hemolytic activity. "[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=8 g/ml; MBC=16 g/ml), Methicillin-resistant Staphylococcus aureus (MIC=16 g/ml; MBC=32 g/ml);##Gram-negative bacterium: Pseudomonas aeruginosa (MIC=64 g/ml; MBC=128 g/ml);##Fungi: Candida albicans (MIC=128 g/ml; MBC=128 g/ml)" "[Ref.29040295] 2% hemolysis at 0.78 g/ml, 5% hemolysis at 1.56 g/ml, 45% hemolysis at 3.13 g/ml, 85% hemolysis at 6.25 g/ml, 98% hemolysis at 12.50 g/ml, 100% hemolysis at 25.00 g/ml against mouse red blood cell" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet "bacterial outer membrane target protein, OprI-binding" 29040295 PLoS One. 2017 Oct 17;12(10):e0186442. "Chang TW, Wei SY, Wang SH, Wei HM, Wang YJ, Wang CF, Chen C, Liao YD." "Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4." DRAMP03002 GIGAVLKVLTTGLPALISWIKRKRQQ 26 "Melittin (Allergen Api m 3; Allergen Api m III; Insects, animals)" "P01501,P01503" Belongs to the melittin family MELT Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "2MLT, 3QRX, 1BH1" "Function: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. It increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. It acts synergistically with phospholipase A2. " "[Ref.29783753] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=2 M), Listeria monocytogenes CMCC 54004 (MIC=1 M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 M), Escherichia coli UB 1005 (MIC=2 M), Salmonella pullorum C7913 (MIC=8 M), Salmonella enterica subsp enterica CMCC 50071 (MIC=2 M)" [Ref.29859288] MHC=1 M against human red blood cell.##[Ref.2978375] 46.80% hemolysis at 2M against human red blood cell##[Ref.20472009] Wild-type melittin:AVG S.D.(%)=0.0770.002 (35) against human red blood cell. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (forms a transmembrane alpha-helix in the cell membrane.) 29859288##29783753##6309516##20472009##20403370##5300771 Gene. 2018 May 30. pii: S0378-1119(18)30617-6.##Molecules. 2018 May 19;23(5). pii: E1220. ##Eur J Biochem. 1983 Sep 1;135(1):123-126.##Peptides. 2010 Aug;31(8):1473-1479.##Toxicon. 2010 Sep 1;56(3):355-362.##Res Dev Tech Rep. 1967 Dec 5:1-13. "Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S.##Hou J, Liu Z, Cao S, Wang H, Jiang C, Hussain MA, Pang S.##Vlasak R, Unger-Ullmann C, Kreil G, Frischauf AM.##Sciani JM, Marques-Porto R, Louren?o Junior A, Orsi Rde O, Ferreira Junior RS, Barraviera B, Pimenta DC.##Ferreira Junior RS, Sciani JM, Marques-Porto R, Junior AL, Orsi Rde O, Barraviera B, Pimenta DC.##Fennell JF, Shipman WH, Cole LJ." Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro.##Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity against Human Cells of a Peptide Derived from Bovine AlphaS1-Casein.##Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin.##Identification of a novel melittin isoform from Africanized Apis mellifera venom.##Africanized honey bee (Apis mellifera) venom profiling: Seasonal variation of DRAMP02237 GLMDTIKGVAKTVAASWLDKLKCKITGC 28 "Ranatuerin-2Ya (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Not found "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Ranatuerin-2Ya showed appreciably greater cytolytic activity against HepG2 cells (LC(50)=20microM) than against erythrocytes (LC(50)>100microM). [Ref.19254736] Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M). [Ref.19254736] LC50>100 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19254736 Toxicon. 2009 Jun;53(7-8):699-705. doi: 10.1016/j.toxicon.2009.02.018. "Conlon JM, Ahmed E, Coquet L, Jouenne T, Leprince J, Vaudry H, King JD." "Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis." DRAMP02238 GLADYWRTAFRANFANLGPGIRCKSARC 28 "Ranatuerin-2ZHa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana zhenhaiensis (Chinese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), Pseudomonas aeruginosa ATCC 9027 (MIC=6 ?M).##Yeast: Candida albicans ATCC 2002 (MIC>32 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22943778 Zoolog Sci. 2012 Sep;29(9):553-558. "Xu B, Che H, Kang L, Zheng S, Mu S, Wan F." "Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis." DRAMP02239 SMISVLKNLGKVGLGFVACKVNKQC 25 "Ranatuerin-1Ga (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grylio (North American pig frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=3.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=60 ?M).##Yeast: Candida albicans (MIC=110 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10828493 Regul Pept. 2000 Jun 30;90(1-3):53-60. "Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM." Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio. DRAMP02241 GLLLDTLKGAAKDIAGIALEKLKCKITGCKP 31 "Ranatuerin-2G (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana grylio (North American pig frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=19 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=150 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10828493 Regul Pept. 2000 Jun 30;90(1-3):53-60. "Kim JB, Halverson T, Basir YJ, Dulka J, Knoop FC, Abel PW, Conlon JM." Purification and characterization of antimicrobial and vasorelaxant peptides from skin extracts and skin secretions of the North American pig frog Rana grylio. DRAMP01390 TSRCYIGYRRKVVCS 15 "Odorranain-T1 (OdT1; Frogs, amphibians, animals)" A6MBS1 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-T1 adopts 28.2% turn structure in water solution. None Function: Odorranain-T1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=17.50 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=35.00 g/ml), Bacillus subtilis (MIC=17.50 g/ml).##Yeast: Candida albicans (MIC=8.75 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01389 FLPPSPWKETFRTS 14 "Odorranain-S1 (OdS1; Frogs, amphibians, animals)" "A6MBS0, A6MBR9" Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-S1 exhibites moderate antimicrobial activities against all of the tested microbes. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=42.50 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=21.25 g/ml), Bacillus subtilis (MIC=85.00 g/ml).##Yeast: Candida albicans (MIC=21.25 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02252 GLLDAIKDTAQNLFANVLDKIKCKFTKC 28 "Ranatuerin 2SKa (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana sakuraii (Japanese brown frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=50 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC>50 ?M).##Yeast: Candida albicans (MIC>50 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization (Cys23 and Cys28) Disulfide bond between Cys23 and Cys28. L No cytotoxicity information found Not found 17174009 Peptides. 2007 Mar;28(3):505-514. "Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM." Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii. DRAMP01108 GIGTKILGGVKTALKGALKELASTYVN 27 "Maximin-2 (Toads, amphibians, animals)" "P83081, P83086, Q58T49" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP03998 RKKWFW 6 PAF26 (Trp-rich; combinatorial library) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Synthetic Rich "In general, positively charged residues (arginine or lysine) and residues with aromatic rings (tryptophan or phenylalanine) rendered antifungal activity." None "Function: Antibacterial against Gram-negative bacterium. The antifungal mixture is also antibacterial, with a predominance of basic and aromatic residues." "[Ref.11976121] Gram-negative bacterium: Escherichia coli DH5 (MIC=160 ?M, IC50>80 ?M);##Fungi: Penicillium digitatum PHI-26 (MIC=20 ?M, IC50=11 1 ?M), Penicillium italicum PHI-1 (MIC=40 ?M, IC50=22 3 ?M), Botrytis cinerea CECT2100 (MIC=60 ?M, IC50=38 24 ?M), Fusarium oxysporum CECT2866 (MIC=80 ?M, IC50=45 4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11976121 Appl Environ Microbiol. 2002 May;68(5):2453-60. "Lpez-Garca B, Prez-Pay E, Marcos JF." Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library. DRAMP01107 GIGTKILGGVKTALKGALKELASTYAN 27 "Maximin-1 (Toads, amphibians, animals)" "P83080, Q58T87" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity. Toxic dose: LD50 is 8.2 mg/kg by intraperitoneal injection into mice. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml);##Virus: HIV-1 (IC50=15.5 ?g/ml, EC50=21.4 ?g/ml);##Cancer cell lines: C8166 (IC50=15.3 ?g/ml), Molt-4 (IC50=24.3 ?g/ml), BIU-87 (IC50=20.5 ?g/ml), T24 (IC50=35.4 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP02268 GWASKIGQTLGKIAKVGLKELIQPK 25 "Xenopsin precursor fragment (XPF; Frogs, amphibians, animals)" P07198 Belongs to the magainin family Not found Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: XPF has antimicrobial activity. Tissue specificity: XPF is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa, it is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli (MIC=16-31 ?g/ml), K. Pneumonae (MIC=62-125 ?g/ml), Pseudomonas aeruginosa (MIC=125-250 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 ?g/ml), Streptococcus faecalis (MIC=250-500 ?g/ml).##Yeast: Candida albicans (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1717472 J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02269 GVLSNVIGYLKKLGTGALNAVLKQ 24 "Antimicrobial peptide PGQ (PGQ; Frogs, amphibians, animals)" P39080 Belongs to the magainin family pgq Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix(potential) Not found None "Function: Antimicrobial peptide. Tissue specificity: Is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli (MIC=62-250 ?g/ml), K. Pneumonae (MIC=125-250 ?g/ml), Pseudomonas aeruginosa (MIC=250-500 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 ?g/ml), Streptococcus faecalis (MIC=250-500 ?g/ml).##Yeast: Candida albicans (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1717472 J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02271 GIGKFLHSAKKFGKAFVGEIMNS 23 "Magainin-2 (Magainin II; chain of Magainins; Frogs, amphibians, animals)" C0HKN6 Belongs to the gastrin/cholecystokinin family. Magainin subfamily. N/A Xenopus ruwenzoriensis (Uganda clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix "The secondary structure is shown to be helical in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution." "2MAG, 2LSA resolved by NMR." "Function: Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents. Tissue specificity: Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin." "Gram-negative bacteria: Escherichia coli D31 (MIC=5 ?g/ml), Klebsiella pneumoniae (MIC=10 ?g/ml), Escherichia coli (MIC=50 ?g/ml), Pseudomonas putida (MIC=10 ?g/ml), Citrobacter freundii (MIC=30 ?g/ml), Enterobacter cloacae (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Serratia marcescens (MIC=100 ?g/ml), Proteus mirabilis (MIC>100 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis (MIC=10 ?g/ml), Staphylococcus aureus (MIC=50 ?g/ml), Streptococcus fecalis (MIC>100 ?g/ml).##Protozoa: Paramecium caudatum (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=80 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 3299384##9090128##PubMed ID is not available Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-5453.##J Biomol NMR. 1997 Feb;9(2):127-135.##To be Published. "Zasloff M.##Gesell J, Zasloff M, Opella SJ.##Vermeer LS, Kozlowska J, Lorenz CD, Mason JA." "Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.##Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution.##All Atom Simulations of the Initial Binding of Magainin and Pleurocidin to Membranes Comprising a Mixture of Anionic and Zwitterionic" DRAMP02272 GMASKAGAIAGKIAKVALKAL 21 "PGLa (chain of PYLa/PGLa A; Frogs, amphibians, animals)" "Q99134, B7ZSG6, Q91826" Belongs to the gastrin/cholecystokinin family (Magainin subfamily) pgla-a AND pgla-b Xenopus laevis (African clawed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: PGLa display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa also displays antifungal activity against C. albicans ATCC 14053. Tissue specificity: Expressed by the skin glands. Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. Stored as active, processed peptides in large granules within the granular gland secretions of the skin. PTM: Leucine amide at position 21." "Gram-negative bacteria: Escherichia coli 25922 (MIC=62-125 ?g/ml), Klebsiella pneumoniae 13883 (MIC=250-500 ?g/ml), Pseudomonas aeruginosa 27853 (MIC=250-500 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=125-500 ?g/ml), Strepococcus faecalis (MIC>500 ?g/ml).##Yeast: Candida albicans 14053 (MIC=250-500 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 3606567##1717472 Biochem J. 1987 Apr 1;243(1):113-120.##J Biol Chem. 1991 Oct 15;266(29):19851-19857. "Giovannini MG, Poulter L, Gibson BW, Williams DH.##Moore KS, Bevins CL, Brasseur MM, Tomassini N, Turner K, Eck H, Zasloff M." Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones.##Antimicrobial peptides in the stomach of Xenopus laevis. DRAMP02274 SAPRGCWTKSYPPKPCK 17 "Ranacyclin-E (Frogs, amphibians, animals)" P83663 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana esculenta (Edible frog) (Pelophylax esculentus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Has hemolytic activity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Tissue specificity: Expressed by the skin granular glands." "[Ref.14636071]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3 ?M), Staphylococcus lentus (MIC=7 ?M), Micrococcus luteus (MIC=5 ?M);##Gram-negative bacteria: Yersinia pseudotuberculosis YP III (MIC=9 ?M), Pseudomonas syringae pv tabaci (MIC=80 ?M);##Fungi: Candida tropicalis (MIC=7.4 ?M), C. guillermondii (MIC=3.4 ?M), Phytophthora nicotianae spores (MIC=32 ?M)." [Ref.14636071] It has 55% hemolytic activity at 100 M against human erythrocytes Cyclic Free Amidation Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Cell membrane 14636071 Biochemistry. 2003 Dec 2;42(47):14023-14035. "Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M." "Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity." DRAMP02275 GALRGCWTKSYPPKPCK 17 "Ranacyclin-T (Frogs, amphibians, animals)" P83719 Belongs to the frog skin active peptide family (Brevinin subfamily) RNCT Rana temporaria (European common frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None MOA: The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores. Has hemolytic activity. "[Ref.14636071]Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3 ?M), Staphylococcus lentus (MIC=10 ?M), Micrococcus luteus (MIC=8 ?M);##Gram-negative bacteria: Escherichia coli D21 (MIC=30 ?M), Yersinia pseudotuberculosis YP III (MIC=5 ?M), Pseudomonas syringae pv tabaci (MIC=16 ?M);##Fungi: Candida albicans ATCC 10231 (MIC=22 ?M), Candida tropicalis (MIC=14 ?M), C. guillermondii (MIC=1 ?M), Phytophthora nicotianae spores (MIC=16 ?M)." [Ref.14636071] It has 20% hemolytic activity at 100 M against human erythrocytes Cyclic Free Amidation Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Cell membrane 14636071 Biochemistry. 2003 Dec 2;42(47):14023-14035. "Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M." "Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity." DRAMP02276 AALKGCWTKSIPPKPCSGKR 20 "Ranacyclin B3 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana grahami (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=11.7 ?M).##Yeast: Candida albicans (MIC=23.4 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02277 AALRGCWTKSIPPKPCSGKR 20 "Ranacyclin B5 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana grahami (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=5.8 ?M).##Yeast: Candida albicans (MIC=23.1 ?M) No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02278 AALRGCWTKSIPPKPCPGKR 20 "Ranacyclin-B-RL1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana livida (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus (MIC=5.8 ?M), Bacillus subtilis (MIC=46.2 ?M);##Gram-negative bacterium: Escherichia coli.##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02281 SALVGCWTKSYPPNPCFGRG 20 "Ranacyclin-B-RN6 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana nigrovittata (Ranidae frogs) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus (MIC=11.7 ?M).##Yeast: Candida albicans (MIC=46.7 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys6 and Cys16. L No cytotoxicity information found Not found 21927839 Amino Acids. 2012 Jul;43(1):309-316. "Yan X, Liu H, Yang X, Che Q, Liu R, Yang H, Liu X, You D, Wang A, Li J, Lai R." Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. DRAMP02288 FIGPVLKIAAGILPTAICKIFKKC 24 "Gaegurin-RN1 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells.. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=2.34 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=4.69 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=18.75 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 ?g/ml)" [Ref.19778602] It has 46.13 1.49% hemolytic activity at 100 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP02289 FVGPVLKIAAGILPTAICKIYKKC 24 "Gaegurin-RN4 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=1.17 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 ?g/ml), Bacillus subtilis (MIC=2.34 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=2.34 ?g/ml)." [Ref.19778602] It has 18.64 0.25% hemolytic activity at 100 g/ml against rabbit red blood cells Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP02290 FLGPIIKIATGILPTAICKFLKKC 24 "Gaegurin-RN5 (Frogs, amphibians, animals)" No entry found Not found Not found Rana nigrovittata "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Has hemolytic activity against rabbit red cells. "[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=3.75 ?g/ml), Staphylococcus aureus ATCC43300 (MIC=62.50 ?g/ml), Bacillus subtilis (MIC=4.69 ?g/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 ?g/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 ?g/ml)." [Ref.19778602] It has no detectable hemolysis at the concentration up to 100 g/ml Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 19778602 Genomics. 2010 Jan;95(1):66-71. "Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R." "Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata." DRAMP02291 SLFSLIKAGAKFLGKNLLKQGACYAACKASKQC 33 "Gaegurin-1 (Gaegurin 1; GGN1; Frogs, amphibians, animals)" P80395 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN1 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has hemolytic activity against rabbit red cells. "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=5 ?g/ml), Staphylococcus epidermidis (MIC=50 ?g/ml), Bacillus subtilis (MIC=50 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=100 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=25 ?g/ml)." "[Ref.7999137] It has 0.04% hemolytic activity at 0.1 g/ml, 0.14% hemolytic activity at 1 g/ml, 0.51% hemolytic activity at 10 g/ml, 0.59% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung J-E, Lee BJ.1994" "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02292 GIMSIVKDVAKNAAKEAAKGALSTLSCKLAKTC 33 "Gaegurin-2 (Gaegurin 2; GGN2; Frogs, amphibians, animals)" P80396 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN2 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=75 ?g/ml).##Fungi: Saccharomyces cerevisiae (MIC=150 ?g/ml), Candida albicans (MIC=150 ?g/ml), Salmonella typhimurium (MIC=150 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.19% hemolytic activity at 0.1 g/ml, 0.16% hemolytic activity at 1 g/ml, 0.31% hemolytic activity at 10 g/ml, 0.82% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02293 GIMSIVKDVAKTAAKEAAKGALSTLSCKLAKTC 33 "Gaegurin-3 (Gaegurin 3; GGN3; Frogs, amphibians, animals)" P80397 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN3 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml), Eshchericia coli (MIC=75 ?g/ml).##Fungi: Saccharomyces cerevisiae (MIC>200 ?g/ml), Candida albicans (MIC>200 ?g/ml), Salmonella typhimurium (MIC=150 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.11% hemolytic activity at 0.1 g/ml, 0.12% hemolytic activity at 1 g/ml, 0.35% hemolytic activity at 10 g/ml, 1.20% hemolytic activity at 100 g/ml against human red blood cells." Cyclic Free Cyclization (Cys27 and Cys33) Disulfide bond between Cys27 and Cys33. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02294 GILDTLKQFAKGVGKDLVKGAAQGVLSTVSCKLAKTC 37 "Gaegurin-4 (Gaegurin 4; GGN4; Frogs, amphibians, animals)" "P80398, Q91328, Q98TA6" Belongs to the frog skin active peptide family (Brevinin subfamily) GGN4 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Alpha helix (3 helices; 22 residues) "In 100% H2O, Gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34 (Ref.2)." 2G9L resolved by NMR. "Function: Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. Has hemolytic activity against rabbit red cells. Tissue specificity: Expressed by the skin glands. PTM: Contains one disulfide bond 31-37." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 ?g/ml), Shigella dysentariae (MIC=25 ?g/ml), Pseudomonas putida (MIC=100 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=75 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=200 ?g/ml), Candida albicans (MIC=200 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.50% hemolytic activity at 0.1 g/ml, 0.74% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 1.67% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys31 and Cys37) Disulfide bond between Cys31 and Cys37. L No cytotoxicity information found Not found 7999137##17141187##11004488 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954.##Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-597.##Biochim Biophys Acta. 2000 Jun 21;1492(1):185-190. "Park JM, Jung JE, Lee BJ.##Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH.##Kwon SY, Carlson BA, Park JM, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa.##Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.##Structural organization and expression of the gaegurin 4 gene of Rana rugosa." DRAMP02295 FLGALFKVASKVLPSVFCAITKKC 24 "Gaegurin-5 (Gaegurin 5; GGN5; Brevinin-1EMa; Frogs, amphibians, animals)" "P80399, Q91329" Belongs to the frog skin active peptide family (Brevinin subfamily) GGN5 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal" Protein level Not found Not found None "Function: Has low hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. PTM: Problely contains one disulfide bond 18-24." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=50 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=50 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=50 ?g/ml), Candida albicans (MIC=50 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.19% hemolytic activity at 0.1 g/ml, 0.31% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 1.01% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02296 FLPLLAGLAANFLPTIICKISYKC 24 "Gaegurin-6 (Gaegurin 6; GGN6; Frogs, amphibians, animals)" P80400 Belongs to the frog skin active peptide family (Brevinin subfamily) GGN6 Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has low hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. PTM: Problely contains one disulfide bond 18-24." "[Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 ?g/ml), Staphylococcus epidermidis (MIC=10 ?g/ml), Bacillus subtilis (MIC=10 ?g/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=50 ?g/ml), Shigella dysentariae (MIC=50 ?g/ml), Pseudomonas putida (MIC=50 ?g/ml), Pseudomonas aeruginosa (MIC=100 ?g/ml), Eshchericia coli (MIC=50 ?g/ml);##Fungi: Saccharomyces cerevisiae (MIC=50 ?g/ml), Candida albicans (MIC=50 ?g/ml), Salmonella typhimurium (MIC=200 ?g/ml), Proteus mirabilis (MIC>200 ?g/ml), Serratia marcescens (MIC>200 ?g/ml)." "[Ref.7999137] It has 0.39% hemolytic activity at 0.1 g/ml, 0.62% hemolytic activity at 1 g/ml, 0.78% hemolytic activity at 10 g/ml, 0.86% hemolytic activity at 100 g/ml against human red blood cells" Cyclic Free Cyclization (Cys18 and Cys24) Disulfide bond between Cys18 and Cys24. L No cytotoxicity information found Not found 7999137 Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. "Park JM, Jung JE, Lee BJ." "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." DRAMP02314 RCRFCCRCCPRMRGCGICCRF 21 "Hepcidin (fish, chordates, animals)" A1Z0M0 Belongs to the hepcidin family hamp Larimichthys crocea (Croceine croaker) (Pseudosciaena crocea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Tissue specificity: Expressed in all tissues tested, with highest levels of expression in kidney and lowest levels in liver. Intra-peritoneal injection of lipopolysaccharide results in increased expression in heart, spleen and stomach, but not in kidney or liver. PTM: Contains four disulfide bonds 2-19; 5-8; 6-15; 9-18." "Gram-negative bacteria: Vibrio alginolyticus(MIC=24 ?M), V. fluvialis, V. harveyis (MIC=12 ?M) and Vibrio parahaemolyticus (MIC=6 ?M), Aeromonas hydrophila (MIC=6 ?M), Escherichia coli (MIC=24 ?M), Escherichia coli BL21(DE3)plysS (MIC=6 ?M);##Gram-positive bacteria: Bacillus cereus (MIC=24 ?M), Bacillus subtilis (MIC=6 ?M), C. glutamicum (MIC=3 ?M), Micrococcus luteus (MIC=3 ?M), M. lysodeikticus, Staphylococcus aureus (MIC=6 ?M) and S.epidermis (MIC=12 ?M).##Fungi: Aspergillus niger (MIC=24 ?M), F;##Graminearum (MIC=24 ?M) and Fusarium solani (MIC=24 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys19; Cys5 and Cys8; Cys6 and Cys15,Cys9 and Cys18." L No cytotoxicity information found Not found 19150638##19344770 Peptides. 2009 Apr;30(4):638-646.##Fish Shellfish Immunol. 2009 Jun;26(6):864-870. "Wang KJ, Cai JJ, Cai L, Qu HD, Yang M, Zhang M.##Zhang J, Yan Q, Ji R, Zou W, Guo G." "Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide.##Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea." DRAMP02330 FFHHIFRGIVHVGKTIHRLVTG 22 "Piscidin-1 (Pis-1; Piscidin 1; fish, chordates, animals)" Q8UUG0 Belongs to the pleurocidin family Not found Morone saxatilis (Striped bass) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "2JOS, 2OJM resolved by NMR." Function: Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria. Also has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores. "[Ref.11713517]Gram-positive bacteria: Enterococcus faecalis VRE (MIC=5-10 ?M), E. faecalis (MIC=2.5-5 ?M), Listeria monocytogenes (MIC=2.5-5 ?M), Micrococcus luteus (MIC=10-20 ?M), Staphylococcus aureus MRSA (MIC=1.25-2.5 ?M), S. epidermitis (MIC=5-10 ?M), S. saprophiticus (MIC=5-10 ?M), Staphylococcus xylosus (MIC>20 ?M), S. agalactiae (MIC=1.25-2.5 ?M), S. bovis (MIC=1.25-2.5 ?M), S. equisimilis (MIC=2.5-5 ?M), S. mitis (MIC=1.25-2.5 ?M), S. Pneumonae (MIC=1.25-2.5 ?M), S. pyrogenes (MIC=1.25-2.5 ?M), Streptococcus iniae KST740 ak (MIC=1.25-2.5 ?M), S. iniae KSTSi 6P (MIC=1.25-2.5 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 ?M), Burkholderia cepacia (MIC>20 ?M), Vibrio Cholera (MIC=2.5-5 ?M), Escherichia coli (MIC=5-10 ?M), Enterobacter cloacae (MIC=10-20 ?M), E. Aerogenes (MIC=10-20 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), K. oxytoca (MIC=5-10 ?M), Salmonella choleraesuis (MIC=10-20 ?M), S. typhimurium (MIC=10-20 ?M), S. arizonae (MIC=10-20 ?M), Serratia marcescens (MIC>20 ?M), Shigella flexneri (MIC=2.5-5 ?M), S. sonnei (MIC=5-10 ?M), Yersinia enterocolitica (MIC=2.5-5 ?M); Fungi: Neurospora crassa (MIC=1.56-3.12 ?M), A. fumigatus (MIC=50-100 ?M), F. axysporum (MIC=0.78-1.56 ?M), F. culmorum (MIC=0.39-0.78 ?M), C. ablicans (MIC=10-20 ?M), C. glabrata (MIC=10-20 ?M), C. lusitania (MIC=10-20 ?M), C. tropacalis (MIC=10-20 ?M)." "[Ref.11713517]10% hemolytic activity at 5 g/mL, 60% hemolytic activity at 10 g/mL, 100% hemolytic activity at 50 g/mL against human erythrocytes " Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11713517 Nature. 2001 Nov 15;414(6861):268-269. "Silphaduang U, Noga EJ." Peptide antibiotics in mast cells of fish. DRAMP02331 FFHHIFRGIVHVGKTIHKLVTG 22 "Piscidin-2 (Pis-2; fish, chordates, animals)" Q8UUG2 Belongs to the pleurocidin family Not found Morone chrysops (White bass) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Seems to disrupt the membranes by adopting an alpha helical conformation. Tissue specificity: Expressed in gill, skin, intestine, spleen, anterior kidney, and blood cells." "Gram-positive bacteria: Enterococcus faecalis (MIC=5-10 ?M), E. faecalis (MIC=2.5-5 ?M), Listeria monocytogenes (MIC=2.5-5 ?M), Micrococcus luteus (MIC=10-20 ?M), Staphylococcus aureus (MIC=1.25-2.5 ?M), S. epidermidis (MIC=5-10 ?M), S. saprophiticus (MIC=5-10 ?M), S. xylosus (MIC>20 ?M), Streptococcus agalactiae (MIC=1.25-2.5 ?M), S. bovis (MIC=1.25-2.5 ?M), S. equisimilis (MIC=2.5-5 ?M), S. mitis (MIC=1.25-2.5 ?M), Streptococcus pneumoniae (MIC=1.25-2.5 ?M), Streptococcus pyogenes (MIC=1.25-2.5 ?M), S. iniae KST740ak (MIC=1.25-2.5 ?M), S. iniae KSTSi 6P (MIC=1.25-2.5 ?M);##Gram-negative bacteria: Aeromonas hydrophila (MIC>20 ?M), Burkholderia cepacia (MIC>20 ?M), Vibrio cholera (MIC=2.5-5 ?M), Escherichia coli (MIC=5-10 ?M), Moraxella catarrhalis (MIC=2.5-5 ?M), Neisseria gonorrhoeae (MIC>20 ?M), Pseudomonas aeruginosa (MIC=5-10 ?M), Enterobacter cloacae (MIC=10-20 ?M), E. aerogenes (MIC=10-20 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), K. oxytoca (MIC=5-10 ?M), Salmonella choleraesuis (MIC=10-20 ?M), Salmonella typhimurium (MIC=10-20 ?M), S. arizonae (MIC=10-20 ?M), Serratia marcescens (MIC>20 ?M), Shigella flexneri (MIC=2.5-5 ?M), S. sonnei (MIC=5-10 ?M), Yersinia enterocolitica (MIC=2.5-5 ?M).##Fungi: Neurospora crassa (MIC=1.56-3.12 ?M), Aspergillus fumigatus (MIC=50-100 ?M), Fusarium oxysporum (MIC=0.78-1.56 ?M), F. culmorum (MIC=0.39-0.78 ?M), Candida albicans (MIC=10-20 ?M), C. glabrata (MIC=10-20 ?M), C. lusitania (MIC=10-20 ?M), C. tropicalis (MIC=10-20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 11739390 J Biol Chem. 2002 Feb 15;277(7):5030-5039. "Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Shimizu C, Bulet P." "Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass." DRAMP02347 GKGRWLERIGKAGGIIIGGALDHL 24 "NRC-1 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "C-terminal NH2, this NRC seris of peptides was identified by gene analysis and biological activity verified using synthetic peptides. " "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 ?g/ml), Aeromonas salmonicida 97-4 (MIC=64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), Escherichia coli UB1005 (MIC=32 ?g/ml), Escherichia coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02348 WLRRIGKGVKIIGGAALDHL 20 "NRC-2 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1a) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>128 ?g/ml), Aeromonas salmonicida 97-4 (MIC=128 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), E. coli UB1005 (MIC=64 ?g/ml), E. coli DC2 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02349 GRRKRKWLRRIGKGVKIIGGAALDHL 26 "NRC-3 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder 1a-1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), Aeromonas salmonicida 97-4 (MIC=4 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), Escherichia coli UB1005 (MIC=8 ?g/ml), Escherichia coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=8 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02350 GWGSFFKKAAHVGKHVGKAALTHYL 25 "Pleurocidin (NRC-4; fish, chordates, animals)" "P81941, P81619, Q9PRJ9, Q90ZY0, Q90VW6" Belongs to the pleurocidin family ple1 AND ple2 Pseudopleuronectes americanus (Winter flounder 2-2.1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 19 residues) "From NMR structural studies with the uniformly (15)N-labeled peptide, a structure of pleurocidin is determined to be in a random coil conformation in aqueous solution whereas it assumes an alpha-helical structure in TFE and in dodecylphosphocholine (DPC) micelles.(Ref.2)" 1Z64?resolved by NMR. May play a role in innate host defense. "Gram-negative bacteria: Escherichia coli (MIC=2.2-3.3 ?M), Leucothrix mucor (MIC>35.0 ?M), Serratia marcescens (MIC>35.0 ?M), Pseudomonas aeruginosa (MIC>35.0 ?M), Aeromonas salmonicida (MIC=17.7-35.0 ?M), Cytophaga aquatilis (MIC=2.2-4.4 ?M), Pasteurella haemolytica (MIC=4.4-8.8 ?M), Salmonella typhimurium I (MIC=8.8-17.7 ?M), Salmonella typhimurium II (MIC=8.8-17.7 ?M);##Gram-positive bacteria: Bacillus subtilis (MIC=1.1-2.2 ?M), Staphylococcus aureus (MIC=17.7-35.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9115266 J Biol Chem. 1997 May 2;272(18):12008-12013. "Cole A.M, Weis P, Diamond G." "Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder." DRAMP02351 FFRLLFHGVHHVGKIKPRA 19 "NRC-10 (fish, chordates, animals)" No entry found Not found Not found Pseudopleuronectes americanus (Winter flounder Z) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), Aeromonas salmonicida 97-4 (MIC=32 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), Escherichia coli UB1005 (MIC=32 ?g/ml), Escherichia coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus C623 (MRSA) (MIC=64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02352 GWKKWLRKGAKHLGQAAIK 19 "NRC-16 (fish, chordates, animals)" No entry found Not found Not found Glyptocephalus cynoglossus (Witch flounder GC3.8-t) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=1 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=0.5 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=16 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=1 ?g/ml), E. coli UB1005 (MIC=2 ?g/ml), E. coli DC2 (MIC=0.5 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02357 FLGALIKGAIHGGRFIHGMIQNHH 24 "Pleurocidin-like peptide WF3 (NRC-5; fish, chordates, animals)" Q90VW7 Belongs to the pleurocidin family ple3 Pseudopleuronectes americanus (Winter flounder 3) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 ?g/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=32 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), Escherichia coli UB1005 (MIC=64 ?g/ml), Escherichia coli DC2 (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506##11113283 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.##Dev Comp Immunol. 2001 Mar;25(2):137-147. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.##Douglas SE, Gallant JW, Gong Z, Hew C." "Novel antimicrobial peptides derived from flatfish genes.##Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum)." DRAMP02358 GWGSIFKHGRHAAKHIGHAAVNHYL 25 "Pleurocidin-like peptide WF4 (NRC-6; fish, chordates, animals)" "Q90ZX8, Q90ZX9" Belongs to the pleurocidin family ple4 Pseudopleuronectes americanus (Winter flounder 4-1.1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=4 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=16 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 ?g/ml).##Yeast: Candida albicans C627 (MIC=32 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506##11113283 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470.##Dev Comp Immunol. 2001 Mar;25(2):137-147. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE.##Douglas SE, Gallant JW, Gong Z, Hew C." "Novel antimicrobial peptides derived from flatfish genes.##Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum)." DRAMP02359 RWGKWFKKATHVGKHVGKAALTAYL 25 "Pleurocidin-like peptide YT2 (NRC-7; fish, chordates, animals; Predicted)" Q7SZH1 Not found ple Limanda ferruginea (Yellowtail flounder YT2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=2 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=64 ?g/ml).##Yeast: Candida albicans C627 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02360 GWKSVFRKAKKVGKTVGGLALDHYLG 26 "Pleurocidin-like peptide AP1 (NRC-11; fish, chordates, animals; Predicted)" Q7SZH4 Not found ple Hippoglossoides platessoides (American plaice AP1) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 ?g/ml), A. salmonicida 97-4 (MIC=8 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=32 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=4 ?g/ml), E. coli UB1005 (MIC=16?g/ml), E. coli DC2 (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC=32 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02361 GWKKWFNRAKKVGKTVGGLAVDHYLG 26 "Pleurocidin-like peptide AP2 (NRC-12; fish, chordates, animals; Predicted)" Q7SZH3 Not found ple Hippoglossoides platessoides (American plaice AP2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), E. coli UB1005 (MIC=8 ?g/ml), E. coli DC2 (MIC=2 ?g/ml);##Gram-positive bacteria: S. epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02362 GWRTLLKKAEVKTVGKLALKHYL 23 "Pleurocidin-like peptide AP3 (NRC-13; fish, chordates, animals; Predicted)" Q7SZH2 Not found ple Hippoglossoides platessoides (American plaice AP3) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 ?g/ml), A. salmonicida 97-4 (MIC=2 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=2 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=1 ?g/ml), Escherichia coli CGSC 4908 (MIC=2 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=2 ?g/ml).##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 ?g/ml).##Yeast: Candida albicans C627 (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02363 AGWGSIFKHIFKAGKFIHGAIQAHND 26 "Pleurocidin-like peptide GcSc4C5 (NRC-14; fish, chordates, animals)" Q7SZH0 Not found ple Glyptocephalus cynoglossus (Witch flounder GcSc4C5) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=32 ?g/ml), A. salmonicida 97-4 (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=16 ?g/ml), E. coli UB1005 (MIC=16 ?g/ml), E. coli DC2 (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=16 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02364 GFWGKLFKLGLHGIGLLHLHL 21 "Pleurocidin-like peptide GcSc4B7 (NRC-15; fish, chordates, animals; Predicted)" Q7SZG9 Not found ple Glyptocephalus cynoglossus (Witch flounder GcSc4B7) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=8 ?g/ml), A. salmonicida 97-4 (MIC=16 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=16 ?g/ml), Pseudomonas aeruginosa K799 (MIC=8 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=4 ?g/ml), Escherichia coli CGSC 4908 (MIC=8 ?g/ml), E. coli UB1005 (MIC=8 ?g/ml), E. coli DC2 (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=4 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=4 ?g/ml).##Yeast: Candida albicans C627 (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02365 GWKKWLRKGAKHLGQAAIKGLAS 23 "Pleurocidin-like peptide GC3.8 (NRC-17; fish, chordates, animals; Predicted)" Q7SZG8 Not found ple Glyptocephalus cynoglossus (Witch flounder GC3.8) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=2 ?g/ml), A. salmonicida 97-4 (MIC=1 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=1 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=4 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=2 ?g/ml), Escherichia coli CGSC 4908 (MIC=1 ?g/ml), E. coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=16 ?g/ml).##Yeast: Candida albicans C627 (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02366 GWKKWFTKGERLSQRHFA 18 "Pleurocidin-like peptide GC3.2 (NRC-18; fish, chordates, animals; Predicted)" Q7SZG7 Not found ple Glyptocephalus cynoglossus (Witch flounder GC3.2) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC=128 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=32 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC 4908 (MIC=64 ?g/ml), E. coli UB1005 (MIC=64 ?g/ml), E. coli DC2 (MIC=64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02367 FLGLLFHGVHHVGKWIHGLIHGHH 24 "Pleurocidin-like peptide Hb26 (NRC-19; fish, chordates, animals; Predicted)" Q7SZG6 Not found ple Hippoglossus hippoglossus (Halibut Hb26) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=16 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC=64 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=8 ?g/ml), Escherichia coli CGSC 4908 (MIC=32 ?g/ml), E. coli UB1005 (MIC=16 ?g/ml), E. coli DC2 (MIC=32 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=8 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC=8 ?g/ml).##Yeast: Candida albicans C627 (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02368 GFLGILFHGVHHGRKKALHMNSERRS 26 "Pleurocidin-like peptide Hb18 (NRC-20; fish, chordates, animals; Predicted)" Q7SZG5 Not found ple Hippoglossus hippoglossus (Halibut Hb18) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 ?g/ml), A. salmonicida 97-4 (MIC>64 ?g/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC>64 ?g/ml), S. enterica serovar Typhimurium 14028s (MIC>64 ?g/ml), Pseudomonas aeruginosa K799 (MIC>64 ?g/ml), Pseudomonas aeruginosa Z61 (MIC=64 ?g/ml), Escherichia coli CGSC 4908 (MIC>64 ?g/ml), E. coli UB1005 (MIC>64 ?g/ml), E. coli DC2 (MIC>64 ?g/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 ?g/ml), Staphylococcus aureus (MRSA) C623 (MIC>64 ?g/ml).##Yeast: Candida albicans C627 (MIC>64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12878506 Antimicrob Agents Chemother. 2003 Aug;47(8):2464-2470. "Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE." Novel antimicrobial peptides derived from flatfish genes. DRAMP02374 GCRFCCNCCPNMSGCGVCCRF 21 "Bass hepcidin (fish, chordates, animals)" P82951 Belongs to the hepcidin family hamp Morone chrysops x Morone saxatilis (white bass x striped sea-bass) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Beta strand (2 strands; 6 residues) "Solution structure by NMR indicates that bass hepcidin is very similar to that of human hepcidin, including the presence of an antiparallel beta-sheet, a conserved disulfide-bonding pattern, and a rare vicinal disulfide bond." 1S6W resolved by NMR. "Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity). Synthetic bass hepcidin is active in vitro against Gram-negative pathogens and fungi but showes no activity against key Gram-positive pathogens and a single yeast strain tested. Tissue specificity: Predominantly expressed in liver. Induction: By bacterial challenge. PTM: Contains four disulfide bonds 2-19; 5-8; 6-15; 9-18." "Gram-negative bacteria: Escherichia coli ATCC 25,922,351,50 (MIC=22 ?M), Escherichia coli ATCC D31K (MIC=11 ?M), Klebsiella pneumoniae ATCC 10,031 (MIC=22 ?M), P. shigelloides ATCC KST (MIC=11 ?M), S. flexneri ATCC 12,022 (MIC=22 ?M), Shigella sonnei ATCC 9290 (MIC=44 ?M), Y. enterocolitica ATCC 23,715 (MIC=22 ?M).##Fungi: Aspergillus niger (MIC=44 ?M)." [Ref.15546886] It displays essentially no hemolytic activity toward HSB erythrocytes Cyclic Free Free "Disulfide bonds between Cys2 and Cys19; Cys5 and Cys8; Cys6 and Cys15,Cys9 and Cys18." L No cytotoxicity information found Not found 11985602##15546886 Eur J Biochem. 2002 Apr;269(8):2232-2237.##J Biol Chem. 2005 Mar 11;280(10):9272-9282. "Shike H, Lauth X, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Shimizu C, Bulet P, Burns JC.##Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME." "Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge.##Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections." DRAMP02391 GWFKKAWRKVKHAGRRVLDTAKGVGRHYLNNWLNRYRG 38 "Hematopoietic antimicrobial peptide-37 (MgCath37; hagfishes, chordates, animals)" Q71MD7 Not found CATH37 Myxine glutinosa (Atlantic hagfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Propionibacterium acnes ATCC 11827 and 33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081 and 13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771, 43935, 12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15019197 Peptides. 2003 Nov;24(11):1655-1667. "Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M." Hagfish intestinal antimicrobial peptides are ancient cathelicidins. DRAMP02393 GFFKKAWRKVKHAGRRVLDTAKGVGRHYVNNWLNRYRZ 38 "HFIAP-1 (HFIAP-2; hagfishes, chordates, animals)" No entry found Not found Not found Myxine glutinosa (Atlantic hagfish) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species. Sequence similarity: Sequences for HFIAP-1 and -2 are identical, but HFIAP-2 is brominated only at residue 7; they differ from MgCath37 by conservative replacements." "Gram-positive bacteria: Propionibacterium acnes ATCC 11827/33179 (MIC=2 ?g/ml), Staphylococcus epidermidi (MIC=2-4 ?g/ml), Streptococcus pyogenes (MIC=4 ?g/ml), Enterococcus faecium (MIC=4-8 ?g/ml), Staphylococcus aureus ATCC 29213 (MIC=8 ?g/ml), Clostridium perfringens ATCC 9081/13124 (MIC=4-32 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml);##Gram-negative bacteria: Bacteroides spp. ATCC 29771/43935/12290 (MIC=0.5-4 ?g/ml), Shigella sonnei (MIC=2-4 ?g/ml), Xanthomonas maltophilia (MIC=2-8 ?g/ml), Salmonella Group B (MIC=4-8 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 ?g/ml), Acinetobacter baumannii (MIC=8-16 ?g/ml), Escherichia coli ATCC 25922 (MIC=8 ?g/ml), Enterobacter aerogenes (MIC=8-16 ?g/ml), Enterobacter cloacae (MIC=8-16 ?g/ml), Klebsiella pneumoniae (MIC=8-16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15019197 Peptides. 2003 Nov;24(11):1655-1667. "Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M." Hagfish intestinal antimicrobial peptides are ancient cathelicidins. DRAMP02402 FLPKMSTKLRVPYRRGTKDYH 21 Antimicrobial peptide scolopin-1 P0CH48 Not found Not found Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide against both Gram-positive, Gram-positive and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells. Tissue specificity: Expressed by the venom gland." "[Ref.19716842]Gram-negative bacteria: Escherichia coli standard strain (MIC=12.5 ?g/ml), E. coli drug-resistant strain (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=1.2 ?g/ml), S. aureus drug-resistant strain (MIC=5.0 ?g/ml), Bacillus dysenteriae standard and drug-resistant strains (MIC=7.5 ?g/ml);##Yeast: Candida albicans (MIC=15 ?g/ml)." [Ref.19716842]25 2% hemolytic activity at 50 g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19716842 Toxicon. 2010 Feb-Mar;55(2-3):274-279. "Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H." Two novel antimicrobial peptides from centipede venoms. DRAMP02403 GILKKFMLHRGTKVYKMRTLSKRSH 25 Antimicrobial peptide scolopin-2 P0CH49 Not found Not found Scolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide against both Gram-positive, -negative and yeast. Also induces histamine release by mast cells and shows hemolytic activities against both human and rabbit red cells. Tissue specificity: Expressed by the venom gland." "[Ref.19716842]Gram-negative bacteria: Escherichia coli standard and drug-resistant strains (MIC=5.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=0.5 ?g/ml), S. aureus drug-resistant strain (MIC=1.0 ?g/ml), Bacillus dysenteriae standard strain (MIC=2.5 ?g/ml), B. dysenteriae drug-resistant strain (MIC=5.0 ?g/ml);##Yeast: Candida albicans (MIC=7.5 ?g/ml)." [Ref.19716842]32 7% hemolytic activity at 50 g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19716842 Toxicon. 2010 Feb-Mar;55(2-3):274-279. "Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H." Two novel antimicrobial peptides from centipede venoms. DRAMP02410 FSKYERQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIKWNEEGLPIYEIPGEGGHAEPAAA 62 Antimicrobial peptide lumbricin-1 O96447 Not found Not found Lumbricus rubellus (Humus earthworm) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Displays antimicrobial activity and weak hemolytic activity. Developmental stage: Adult-specific. Not detected in eggs or 1-week-old worms but abundant in 6-month-old worms. Induction: Constitutively expressed. Not induced by bacterial infection." "[Ref.9784609]Gram-positive bacteria: Bacillus subtilis ATCC 62037 (MIC=12 ?g/ml), Staphylococcus aureus ATCC 15752 (MIC=16 ?g/ml), Streptococcus mutans ATCC 25175 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 27325 (MIC=12 ?g/ml), Pseudomonas putidaATCC 17426 (MIC=16 ?g/ml), Serratia sp. ATCC 21074 (MIC=16 ?g/ml);##Fungi: Candida albicans ATCC 10231 (MIC=16 ?g/ml), Cryptococcus neoformance ATCC 34881 (MIC=25 ?g/ml), Saccharomyces cerevisiae ATCC 44774 (MIC=12 ?g/ml).##NOTE: Minimal inhibitory concentrations were determined by incubating approximately 104C105 CFU/ml of cells with serial dilutions of each peptide in a 96-well microtiter plate." "[Ref.9784609]0.02% hemolytic activity at 5 g/ml, 0.06% hemolytic activity at 10 g/ml, 0.14% hemolytic activity at 25 g/ml, 0.19% hemolytic activity at 50 g/ml, 0.23% hemolytic activity at 100 g/ml against human erythrocytes " Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784609 Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76. "Cho JH, Park CB, Yoon YG, Kim SC." "Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization." DRAMP02423 DFGCARGMIFVCMRRCARMYPGSTGYCQGFRCMCDTMIPIRRPPFIMG 48 "HlMS-defensin (Ticks, Arthropods, animals)" No entry found Not found Not found Haemaphysalis longicornis (Tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=18.8 ?g/ml), Bacillus licheniformis (MIC=9.4 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=28.1 ?g/ml), Pseudomonas aeruginosa ATCC27853 (MIC=37.5 ?g/ml), Serratia rubidaea (MIC=28.1 ?g/ml), Psychrobacter faecalis (MIC=2.3 ?g/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22033149 Dev Comp Immunol. 2012 May;37(1):207-211. "Zheng H, Zhou L, Yang X, Wang D, Liu J." Cloning and characterization of a male-specific defensin-like antimicrobial peptide from the tick Haemaphysalis longicornis. DRAMP02425 QLKVDLWGTRSGIQPEQHSSGKSDVRRWRSRY 32 "Ixosin-B (Ticks, Arthropods, animals)" A7UDM9 Not found Not found Ixodes sinensis (Hard tick) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antifungal and antibacterial activity. Ixosin-B has little hemolytic activity on red blood cells even with peptide concentrations up to 200 ?g/mL." [Ref.18295522]Gram-positive bacterium: Staphylococcus aureus (MIC=2.5 ?g/mL);##Gram-negative bacterium: Escherichia coli (MIC=15 ?g/mL);##Yeast: Candida albicans (MIC=7.5 ?g/mL). [Ref.18295522]Little hemolytic activity on rabbit red blood cells up to 200 g/mL Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18295522 Comp Biochem Physiol B Biochem Mol Biol. 2008 Apr;149(4):557-561. "Liu Z, Liu H, Liu X, Wu X." "Purification and cloning of a novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis." DRAMP02430 GLHKVMREVLGYERNSYKKFFLR 23 "Ixosin (Ticks, Arthropods, animals)" Q2LKX9 Not found Not found Ixodes sinensis (Hard tick) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antifungal activity against C. albicans. Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli. Little hemolytic activity against rabbit erythrocytes. [Ref.16087274]Gram-postive bacteria: Staphylococcus aureus (MIC=3.7 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=30 ?g/ml);##Fungi: Candida albicans (MIC=7.5 ?g/ml). [Ref.16087274]Little hemolytic activity on rabbit red blood cells up to 50 g/mL Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16087274 Peptides. 2006 Jan;27(1):31-5. "Yu D, Sheng Z, Xu X, Li J, Yang H, Liu Z, Rees HH, Lai R." "A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis." DRAMP02433 HHQELCTKGDDALVTELECIRLRISPETNAAFDNAVQQLNCLNRACAYRKMCATNNLEQAMSVYFTNEQIKEIHDAATACDPEAHHEHDH 90 "Antimicrobial peptide microplusin (Microplusin; Ticks, Arthropods, animals)" Q86LE5 Not found Not found Boophilus microplus (Cattle tick) "Antimicrobial, Antifungal, Antibacterial" Protein level Alpha helix "Microplusin consists of five alpha-helices: alpha1 (residues Gly-9 to Arg-21), alpha2 (residues Glu-27 to Asn-40), alpha3 (residues Arg-44 to Thr-54), alpha4 (residues Leu-57 to Tyr-64), and alpha5 (residues Asn-67 to Cys-80). The N and C termini are disordered." 2KNJ?resolved by NMR. "Function: Has bacteriostatic activity against the Gram-positive bacterium M.luteus. Has fungistatic activity against C.neoformans. Binds and sequesters copper and iron ions. Copper-chelating is crucial for antimicrobial activity against M.luteus. Tissue specificity: Expressed in the hemocytes, fat body and ovaries. PTM: Contains three disulfide bonds 6-52; 19-80; 41-46." "Micrococcus luteus (MIC=0.38-0.76 ?M), Cryptococcus neoformans." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys6 and Cys52,Cys19 and Cys80,Cys41 and Cys46." L No cytotoxicity information found Metal-binding: copper II and iron II 14642886##19828445 Dev Comp Immunol. 2004 Mar;28(3):191-200.##J Biol Chem. 2009 Dec 11;284(50):34735-34746. "Foga?a AC, Lorenzini DM, Kaku LM, Esteves E, Bulet P, Daffre S.##Silva FD, Rezende CA, Rossi DC, Esteves E, Dyszy FH, Schreier S, Gueiros-Filho F, Campos CB, Pires JR, Daffre S." "Cysteine-rich antimicrobial peptides of the cattle tick Boophilus microplus: isolation, structural characterization and tissue expression profile.##Structure and mode of action of microplusin, a copper II-chelating antimicrobial peptide from the cattle tick Rhipicephalus (Boophilus) microplus." DRAMP02439 FTCAISCDIKVNGKPCKGSGEKKCSGGWSCKFNVCVKV 38 U-theraphotoxin-Aju1a (U-TRTX-Aju1a; Juruin) B3EWQ0 Belongs to the huwentoxin-2 family Not found Avicularia juruensis (Yellow-banded pinktoe) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has strong antifungal activity. Has no hemolytic activity against human erythrocytes. Probable ion channel inhibitor (By similarity). Tissue specificity: Expressed by the venom gland. PTM: Contains three disulfide bonds 3-24; 7-30; 16-35." "[Ref. Front.Microbiol.2012 Sep;3:324-324.]Fungi: Candida albicans MDM8, C. albicans IOC 45588 (MIC=2.5-5 ?M), C. krusei IOC 4559 (MIC=2.5-5 ?M), C. glabrata IOC 45658 (MIC=2.5-5 ?M), C. parapsilosis IOC 456416 (MIC=2.5-5 ?M), C. tropicalis IOC 45608 (MIC=2.5-5 ?M), C. guilliermondii IOC 455716 (MIC=2.5-5 ?M) and Aspergillus niger (MIC=5-10 ?M)" [Ref. 22973266] It has no hemolytic activity at 10M against human human erythrocytes Cyclic Free Free "Disulfide bonds between Cys3 and Cys24,Cys7 and Cys30,Cys16 and Cys35." L No cytotoxicity information found Not found PubMed ID is not available Front. Microbiol. 2012 Sep;3:324-324. "Ayroza G, Ferreira ILC, Sayegh RSR, Tashima AK, Silva jr PI." "Juruin: an antifungal juruentoxin peptide from the venom of the amazonian pink toe spider, Avicularia juruensis, which contains the inhibitory cystine knot motif." DRAMP02449 TGVAWRIT 8 Lectin P86922 Not found Not found Ganoderma lucidum (Ling zhi medicinal fungus) (Bracket fungus) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has metal-independent hemagglutinating activity against erythrocytes from human, sheep, goat, rat, rabbit and chicken. Hemagglutinating activity is inhibited by glycoproteins fetuin, asialo-fetuin, fibrinogen, asialo-fibrinogen, thyroglobulin, bovine (BSM) as well as porcine submaxillary mucin and asialo-BSM but not by sugars alpha-L-fucose, D-glucose, D-galactose, D-glucosamine, D-galactosamine, lactose, D-melibiose, D/L-mannose, D-mannosamine, D-raffinose, L-rhamnose, xylose, glacaturonic acid or N-acetylglucosamine. Has antifungal activity. Biophysicochemical properties: pH dependence (Hemagglutinating activity is stable from pH 4 to pH 9 but drops sharply below pH 4 and above pH 9); Temperature dependence (Hemagglutinating activity is stable below 60 degrees Celsius but drops sharply to about 20% at 80 degrees Celsius)." "Fungi: Fusarium oxysporum (MIC=20 ?g/ml), Penicillium chrysogenum (MIC=35 ?g/ml), Aspergillus niger (MIC=50 ?g/ml), Cladosporium musae (MIC=60 ?g/ml), Botrytis cinerea (MIC=65 ?g/ml), Trichophyton rubrum (MIC=65 ?g/ml), T. tonsurans (MIC=20 ?g/ml), T. interdigitale (MIC=20 ?g/ml), Epidermophyton floccosum (MIC=15 ?g/ml), Microsporum canis (MIC=70 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21728991 Protein Pept Lett. 2011 Nov;18(11):1150-1157. "U Girjal V, Neelagund S, Krishnappa M." Ganoderma lucidum: A source for novel bioactive lectin. DRAMP02473 KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF 30 "Cathelicidin-BF (Cathelicidin-related protein; Snakes, reptiles, animals)" B6D434 Not found Not found Bungarus fasciatus (Banded krait) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane. No hemolytic and cytotoxic activities have been observed on mammalian cells. Tissue specificity: Expressed by the venom gland, stomach, trachea, skin, muscle, heart, kidney, lung, brain, intestine, spleen, liver, and ovary. Miscellaneous: A predicted cleavage site is located at position Val-157-158-Lys, giving a peptide of 34 residues instead of the 30 residues found for the purified protein. The 30 residues cathelicidin-BF could result from a further processing." "[Ref.18795096]Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=1.2 ?g/ml), P. aeruginosa IS/DR (MIC=2.3 ?g/ml), P. aeruginosa 08031205 IS/DR (MIC=9.4 ?g/ml), P. aeruginosa 08031014 IS/DR (MIC=18.7 ?g/ml), Escherichia coli ATCC25922 (MIC=2.3 ?g/ml), E. coli 08A852 IS/DR (MIC=1.2 ?g/ml), E. coli 08A866 IS/DR (MIC=0.6 ?g/ml), E. coli 08031017 IS/DR (MIC=2.3 ?g/ml), E. coli 08032813 IS/DR (MIC=2.3 ?g/ml), E. coli 08040726 IS/DR (MIC=0.6 ?g/ml), E. coli 08040722 IS/DR (MIC=0.6 ?g/ml), Klebsiella pneumoniae IS/DR (MIC=4.7 ?g/ml), K. pneumoniae 08031012 IS/DR (MIC=9.4 ?g/ml), K. pneumoniae 08040202 IS/DR (MIC=0.6 ?g/ml), K. pneumoniae 08040724 IS/DR (MIC=0.3 ?g/ml), Pseudomonas luteola (MIC=1.2 ?g/ml), Salmonella Typhi IS/DR (MIC=1.2 ?g/ml), Acinetobacter calcoaceticus (MIC=2.3 ?g/ml), Sphingobacterium siyangense (MIC=9.4 ?g/ml), Saccharibacillus kuerlensis (MIC=4.7 ?g/ml);##Gram-positive bacteria: Bacillus subtilis (MIC=9.4 ?g/ml), B. pumilus (MIC=9.4 ?g/ml), B. cereus (MIC=1.2 ?g/ml), Staphylococcus aureus ATCC2592 (MIC=4.7 ?g/ml), S. aureus 08A875 IS/DR (MIC=75 ?g/ml), S. aureus 08031002 IS/DR (MIC>100 ?g/ml), S. aureus 08031013 IS/DR (MIC>100 ?g/ml), S. aureus 08032706 IS/DR (MIC>100 ?g/ml), S. aureus 08032712 IS/DR (MIC>100 ?g/ml), S. aureus 08032810 IS/DR (MIC>100 ?g/ml), Enterococcus faecium IS/DR (MIC=150 ?g/ml);##Fungi: Aspergillus terreus GIM3.34 (MIC=18.7 ?g/ml), Aspergillus nidulans (MIC=18.7 ?g/ml), Candida albicans ATCC2002 (MIC=4.7 ?g/ml), Pichia pastoris (MIC=0.3 ?g/ml)." [Ref.18795096]Non-hemolytic activity at 400 ?g/ml against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 18795096##18620012 PLoS One. 2008 Sep 16;3(9):e3217.##Peptides. 2008 Oct;29(10):1685-1691. "Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R.##Zhao H, Gan TX, Liu XD, Jin Y, Lee WH, Shen JH, Zhang Y." Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics.##Identification and characterization of novel reptile cathelicidins from elapid snakes. DRAMP02474 KFFRKLKKSVKKRAK 15 "cathelicidin-BF15 (Snakes, reptiles, animals)" B6D434 Not found Not found Bungarus fasciatus (Banded krait) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Pseudomonas aeruginosa ATCC27853 (MIC=4.7 ?g/ml), P. aeruginosa IS/DR (MIC=37.5 ?g/ml), P. aeruginosa 08031205 IS/DR (MIC=18.7 ?g/ml), P. aeruginosa 08031014 IS/DR (MIC=75 ?g/ml), Escherichia coli ATCC25922 (MIC=18.7 ?g/ml), E. coli 08A852 IS/DR (MIC=18.7 ?g/ml), E. coli 08A866 IS/DR (MIC=18.7 ?g/ml), E. coli 08031017 IS/DR (MIC=37.5 ?g/ml), E. coli 08040722 IS/DR (MIC=9.4 ?g/ml), K. pneumoniae 08040202 IS/DR (MIC=75 ?g/ml), Salmonella Typhi IS/DR (MIC=1.2 ?g/ml), Saccharibacillus kuerlensis (MIC=4.7 ?g/ml).##Gram-positive bacteria: Bacillus subtilis (MIC=75 ?g/ml), Staphylococcus aureus ATCC2592 (MIC=75 ?g/ml), S. aureus 08A875 IS/DR (MIC=75 ?g/ml), S. aureus 08031002 IS/DR (MIC>100 ?g/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.7 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18795096 PLoS One. 2008 Sep 16;3(9):e3217. "Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R." Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. DRAMP02573 QVYKGGYTRPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS 62 "Penaeidin-3a (Pen-3a; shrimps, Arthropods, animals)" P81058 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity. Tissue specificity: Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain. Developmental stage: Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours. PTM: C-terminal amidation and contains three disulfide bonds 32-47; 36-54; 48-55." "Gram-positive bacteria: Aerococcus viridans (MIC=0.3-0.6 ?M), Micrococcus luteus (MIC=1.25-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Enterococcus fecalis (MIC>20 ?M), Saphylococcus aureus (MIC>40 ?M);##Gram-negative bacteria: Escherichia coli 363 (MI=10-20 ?M), Vibrio vulnificus (MIC>20 ?M), Salmonella thyphimurium (MIC>40 ?M), Klebsiella pneumoniae (MIC>40 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Neurospora crassa (MIC=1.25-2.5 ?M), Aspergillus fumigatus (MIC>20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic pyroglutamic acid Amidation "Disulfide bonds between Cys32 and Cys47,Cys36 and Cys54,Cys48 and Cys55. O-glycosylated on Thr8" L No cytotoxicity information found Chitin-binding 9353298##10561573##12842879 J Biol Chem. 1997 Nov 7;272(45):28398-28406.##Eur J Biochem. 1999 Dec;266(2):335-346.##J Biol Chem. 2003 Sep 19;278(38):36859-36867. "Destoumieux D, Bulet P, Loew D, Van Dorsselaer A, Rodriguez J, Bachre E.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bachre E.##Yang Y, Poncet J, Garnier J, Zatylny C, Bachre E, Aumelas A." "Penaeidins, a new family of antimicrobial peptides isolated from the shrimp Penaeus vannamei (Decapoda).##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp.##Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide." DRAMP02574 QVYKGGYARPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYSG 63 "[T8A]-Penaeidin-3a ([T8A]-Pen-3a; shrimps, Arthropods, animals)" P81058 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 11 residues) "[T8A]-Pen-3a structure consists of an unconstrained and a constrained part, which roughly match with the proline-rich (1-28 residues) and the cysteine-rich (29-58 residues) domains, respectively. The proline-rich domain does not adopt a constrained structure, whereas the cysteine-rich domain adopts a well-defined structure that consists of a helix (41-50 residues) tightly bound to the upstream (27-40 residues) and the downstream (51-63 " 1UEO resolved by NMR. "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity. PTM: Contains three disulfide bonds." "Gram-positive bacteria: Aerococcus viridans (MIC=0.4-0.8 ?M), Micrococcus luteus (MIC=0.8-1.6 ?M), Bacillus megaterium (MIC=3.12-6.25 ?M);##Gram-negative bacteria: Escherichia coli 363 (MI=3.12-6.25 ?M), Vibrio vulnificus (MIC>50 ?M), Salmonella thyphimurium (MIC>50 ?M), Klebsiella pneumoniae (MIC>50 ?M).##Fungi: Fusarium oxysporum (MIC=3.12-6.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic pyroglutamic acid Amidation "Disulfide bonds between Cys32 and Cys47,Cys36 and Cys54,Cys48 and Cys55. O-glycosylated on Thr8" L No cytotoxicity information found Not found 12842879 J Biol Chem. 2003 Sep 19;278(38):36859-36867. "Yang Y, Poncet J, Garnier J, Zatylny C, Bachre E, Aumelas A." "Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide." DRAMP02584 HSSGYTRPLPKPSRPIFIRPIGCDVCYGIPSSTARLCCFRYGDCCHR 47 "Penaeidin-4a (Pen-4a; shrimps, Arthropods, animals)" Q95NT0 Belongs to the penaeidin family Not found Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity (By similarity). PTM: Contains three disulfide bonds 23-37; 26-44; 38-45 and C-terminal amidation." "Gram-positive bacteria: Aerococcus viridans (MIC=1.9-2.92 ?M), Micrococcus luteus (MIC=1.9-2.92 ?M), Bacillus megaterium (MIC>50 ?M), Saphylococcus aureus (MIC>50 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC=22-33 ?M), Vibrio vulnificus (MIC>50 ?M), Salmonella thyphimurium (MIC>50 ?M), Klebsiella pneumoniae (MIC>50 ?M).##Fungi: Fusarium oxysporum (MIC=0.84-1.26 ?M), Botrytis cinerea (MIC=4.38-6.57 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation "Disulfide bonds between Cys23 and Cys37,Cys26 and Cys44,Cys38 and Cys45." L No cytotoxicity information found Chitin-binding 12242595##15084144 Immunogenetics. 2002 Sep;54(6):442-445.##Biochem J. 2004 Jul 1;381(Pt 1):79-86. "Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Cuthbertson BJ, Bullesbach EE, Fievet J, Bachre E, Gross PS." Diversity of the penaeidin antimicrobial peptides in two shrimp species.##A new class (penaeidin class 4) of antimicrobial peptides from the Atlantic white shrimp (Litopenaeus setiferus) exhibits target specificity and an independent proline-rich-domain function. DRAMP02586 QRGGFTGPIPRPPPHGRPPLGPICNACYRLSFSDVRICCNFLGKCCHLVK 50 "Penaeidin-2d (Pen-2d; shrimps, Arthropods, animals)" Q962A9 Belongs to the penaeidin family Not found Litopenaeus setiferus (Atlantic white shrimp) (Penaeus setiferus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Homology Not found Not found None "Function: Antibacterial and antifungal activity. Presents chitin-binding activity (By similarity). Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of hemocytes and to a lesser." "Gram-positive bacteria: Aerococcus viridans (MIC=1.25-2.5 ?M), Micrococcus luteus (MIC=2.5-5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Enterococcus fecalis (MIC>20 ?M), Saphylococcus aureus (MIC>20 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC>40 ?M), Vibrio vulnificus (MIC>20 ?M), Salmonella thyphimurium (MIC>20 ?M), Klebsiella pneumoniae (MIC>20 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Neurospora crassa (MIC=2.5-5 ?M), Aspergillus fumigatus (MIC>20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 12242595##10561573 Immunogenetics. 2002 Sep;54(6):442-445.##Eur J Biochem. 1999 Dec;266(2):335-346. "Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Destoumieux D, Bulet P, Strub JM, Van Dorsselaer A, Bachre E." "Diversity of the penaeidin antimicrobial peptides in two shrimp species.##Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp." DRAMP02591 HSSGYTRPLRKPSRPIFIRPIGCDVCYGIPSSTARLCCFRYGDCCHL 47 "Penaeidin-4d (Pen-4d; shrimps, Arthropods, animals)" Q962A7 Belongs to the penaeidin family Not found Litopenaeus setiferus (Atlantic white shrimp) (Penaeus setiferus) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Alpha helix (1 helices; 9 residues) "Calculation of PEN4 three-dimensional structure reveales that the PEN4 structure consisted of an unconstrained and a constrained part, which roughly match with the PRD (residues 1-17) and the CRD (residues 18-47), respectively. The global fold of the CRD mainly consisted of a helix (residues 31-41), two turns of type IV (Cys23-Cys26 and Gly42-Cys45 residues), and one loop spanning 27-30 residues (Ref.2)." 1XV3 resolved by NMR. "Function: Posesses antibacterial and antifungal activity. Presents chitin-binding activity (By similarity). PTM: Contains three disulfide bonds 23-37; 26-44; 38-45." "Fungi: Fusarium oxysporum (MIC=0.84-1.26 ?M), Botrytis cinerea (MIC=4.38-6.57 ?M), Penicillium crustosum (MIC=1.26-1.9 ?M).## Gram-positive bacteria: Aerococcus viridans (MIC=1.9-2.92 ?M), Bacillus megaterium (MIC>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 12242595##15699044 Immunogenetics. 2002 Sep;54(6):442-445.##J Biol Chem. 2005 Apr 22;280(16):16009-18. "Cuthbertson BJ, Shepard EF, Chapman RW, Gross PS.##Cuthbertson BJ, Yang Y, Bachre E, Bllesbach EE, Gross PS, Aumelas A." Diversity of the penaeidin antimicrobial peptides in two shrimp species.##Solution structure of synthetic penaeidin-4 with structural and functional comparisons with penaeidin-3. DRAMP02603 AALRGALRAVARVGKAILPHVAIANPYVRTPYVHNNP 37 "Putative antimicrobial peptide A Northern Europe Heligoland (chordates, animals)" No entry found Not found Not found Ciona intestinalis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus megaterium (MIC=0.1 ?M), Bacillus subtilis (MIC=3.1 ?M), Staphylococcus aureus (MIC>25 ?M), Staphylococcus epidermidis (MIC=25 ?M).##Gram-negative bacteria: Escherichia coli K12 D31 (MIC=0.8 ?M), Y. enterocolitica (MIC=3.1 ?M), Klebsiella pneumoniae (MIC>25?M), Pseudomonas aeruginosa (MIC=12.5 ?M), Serratia marcescens(MIC>25 ?M).##Fungi: Candida albicans ATCC 10261 (MIC=6.3 ?M), Candida albicans SC 5314 (MIC=6.3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17658598 Dev Comp Immunol. 2008;32(3):286-298. "Fedders H, Leippe M." A reverse search for antimicrobial peptides in Ciona intestinalis: identification of a gene family expressed in hemocytes and evaluation of activity. DRAMP02609 RLGDILQKAREKIEGGLKKLVQKIKDFFGKFAPRTES 37 "CjaRL-37 (cathelicidin; primates, mammals, animals)" No entry found Not found Not found Platyrrhini (New World monkeys) "Antimicrobial, Antibacterial, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "In 20% TSB in SPB medium: Escherichia coli (MIC=4 ?M), Pseudomonas aeruginosa (MIC>32 ?M); Staphylococcus aureus (MIC=32 ?M), Enterococcus faecalis (MIC>32 ?M).##In 20% SAB in SPB medium: Candida albicans (MIC>32 ?M). In 5% SAB in SPB Candida albicans (MIC>32 ?M). In 20% SAB in PIL Candida albicans (MIC>32 ?M).##In 5% TSB in SPB Escherichia coli (MIC=1 ?M), Pseudomonas aeruginosa (MIC=2 ?M), Staphylococcus aureus (MIC=8-16 ?M).##In 20% TSB in PIL Escherichia coli (MIC>32 ?M), Pseudomonas aeruginosa (MIC>32 ?M); Staphylococcus aureus (MIC=16 ?M), Enterococcus faecalis (MIC>32 ?M).##In 50% MH in SPB medium Escherichia coli (MIC>32 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16720578 J Biol Chem. 2006 Jul 21;281(29):19861-19871. "Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A." Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity. DRAMP02727 SLGNFFRKARKKIGEEFKRIVQRIKDFLQHLIPRTEA 37 "HmdSL-37 (cathelicidin; primates, mammals, animals)" No entry found Not found Not found Hylobates sp. (Gibbon) "Antimicrobial, Antibacterial, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "In 20% TSB in SPB medium Escherichia coli (MIC=2 ?M), Pseudomonas aeruginosa (MIC=8 ?M), Staphylococcus aureus (MIC>32 ?M), Enterococcus faecalis (MIC=8 ?M).##In 20% SAB in SPB Candida albicans (MIC>32 ?M). In 5% SAB in SPB Candida albicans (MIC=8 ?M). In 20% SAB in PIL Candida albicans (MIC>32 ?M).##In 5% TSB in SPB Escherichia coli (MIC=1 ?M), Pseudomonas aeruginosa (MIC=2 ?M), Staphylococcus aureus (MIC=2 ?M).##In 20% TSB in PIL Escherichia coli (MIC>32 ?M), Pseudomonas aeruginosa (MIC=16-32 ?M); Staphylococcus aureus (MIC=8-16 ?M), Enterococcus faecalis (MIC>32 ?M).##In 50% MH in SPB medium Escherichia coli (MIC>32 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16720578 J Biol Chem. 2006 Jul 21;281(29):19861-19871. "Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A." Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity. DRAMP02740 YDLSKNCRLRGGICYIGKCPRRFFRSGSCSRGNVCCLRFG 40 "TBD-1 (Turtle beta-defensin 1; Reptiles, animals)" P86253 Belongs to the beta-defensin family Not found Emys orbicularis (European pond turtle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antimicrobial activity against the Gram-positive bacteria methicillin-resistant S. aureus ATCC 33591 and L. monocytogenes EGD, the Gram-negative bacterium E. coli ML53p and the yeast C. albicans 820. Has no hemolytic activity towards human erythrocytes. PTM: Contains three disulfide bonds 7-35; 14-29; 19-36." "[Ref.19253295]Gram-negative bacterium (LS, HS): Escherichia coli ML35p (MIC=0.65, >20 ?mol/L);##Gram-positive bacteria: (LS, HS): Listeria monocytogenes EGD (MIC=0.65, >20 ?mol/L), Methicillin-resistant Staphylococcus aureus ATCC 33591 (MIC=5.6, >20 ?mol/L).##Yeast: Candida albicans (MIC=5.2, >20 ?mol/L).##NOTE: LS (low salt): 10 mmol/L sodium phosphate buffer (pH 7.4) and HS (high salt): 10 mmol/L sodium-phosphate buffer (pH 7.4), 0.1 mol/L sodium chloride." [Ref.19253295] It has no hemolytic activity against human erythrocytes up to 25 mmol/L Cyclic Free Free Disulfide bonds between Cys7 and Cys35; Cys14 and Cys29; Cys19 and Cys36. L No cytotoxicity information found Not found 19253295 Proteomics. 2009 Mar;9(5):1364-1373. "Stegemann C, Kolobov A Jr, Leonova YF, Knappe D, Shamova O, Ovchinnikova TV, Kokryakov VN, Hoffmann R." "Isolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles." DRAMP02768 GLGSVFGRLARILGRVIPKVAKKLGPKVAKVLPKVMKEAIPMAVEMAKSQEEQQPQ 56 "Pilosulin-1 (Myr b I; ants, insects, animals)" "Q07932, Q9TWC1" Belongs to the pilosulin family Not found Myrmecia banksi (Jack jumper ant) (Australian jumper ant) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. The synthesized peptide 57-76 shows a potent and broad spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, and also against the fungus C. albicans. Adopts an alpha-helical structure. Tissue specificity: Expressed by the venom gland. Allergenic properties: Causes an allergic reaction in human." "[Ref.9813247]Gram-positive bacteria: Micrococcus luteus (MIC=0.5 ?M), Enterococcus spp.I-11305b (MIC=2 ?M), Enterococcus spp. I-11054 (MIC=2 ?M), Staphylococcus simulans 22 (MIC=2 ?M), S. haemolyticus I-10925 (MIC=2 ?M), S. epidermidis LT1324 (MIC=2 ?M), S. aureuss 5185 (MI=2 ?M), S. aureuss methicillin-sensitive I-11574 (MIC=2 ?M), S. aureuss (MRSA) LT1338 (MIC=3 ?M), S. aureuss (MRSA) LT1334 (MIC=1.5 ?M);##Gram-negative bacteria: Citrobacter freundii I-11090 (MIC=2 ?M), Klebsiella pneumoniae I-10910 (MIC=2 ?M), Escherichia coli I-11276b (MIC=4 ?M), E. coli O-19592 (MIC=2 ?M), Stenotrophomonas maltophilia O-16451 (MIC=2 ?M), S. maltophila I-10717 (MIC=2 ?M), Pseudomonas aeruginosa 4991 (MIC=4 ?M), Pseudomonas aeruginosa I-10968 (MIC=4 ?M);##Fungi: Candida albicans I-11301 (MIC=4 ?M), Candida albicans I-11134 (MIC>4 ?M)." [Ref.9813247]Complete lysis in the presence of pilosulin 1 was obtained at a concentration of 40 M with evidence of partial lysis visible down to 1.25 M Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet IgE 9813247##9701394##15639237##8866004 Arch Biochem Biophys. 2005 Feb 15;434(2):358-364.##Cytometry. 1998 Aug 1;32(4):268-273.##Arch Biochem Biophys. 2005 Feb 15;434(2):358-364.##Biochem Mol Biol Int. 1996 Aug;39(5):877-885. "Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.##King MA, Wu QX, Donovan GR, Baldo BA.##Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.##Donovan GR, Street MD, Tetaz T, Smith AI, Alewood D, Alewood P, Sutherland SK, Baldo BA." Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.##Flow cytometric analysis of cell killing by the jumper ant venom peptide pilosulin 1.##Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.##Expression of jumper ant (Myrmecia pilosula) venom allergens: post-translational processing of allergen gene products. DRAMP02774 CIKNGNGCQPDGSQGNCCSRYCHKEPGWVAGYCR 34 "Antimicrobial peptide Alo-1 (Alo-1; knottin-type peptide; Insects, animals)" P83651 Belongs to the AMP family Not found Acrocinus longimanus (Giant harlequin beetle) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Has antifungal activity against C. glabrata. Domain: The presence of a disulfide through disulfide knot' structurally defines this protein as a knottin. PTM: Contains three disulfide bonds 1-18; 8-22; 17-33." "Fungi: Candida glabrata patient 1 (MIC>64 ?g/mL), C. albicans IHEM 8060 (MIC=64 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys1 and Cys18; Cys8 and Cys22; Cys17 and Cys33. L No cytotoxicity information found Not found 14661954 Biochemistry. 2003 Dec 16;42(49):14434-14442. "Barbault F, Landon C, Guenneugues M, Meyer JP, Schott V, Dimarcq JL, Vovelle F." Solution structure of Alo-3: a new knottin-type antifungal peptide from the insect Acrocinus longimanus. DRAMP02776 CIKNGNGCQPNGSQGNCCSGYCHKQPGWVAGYCRRK 36 "Antimicrobial peptide Alo-3 (Alo-3; knottin-type peptide; Insects, animals)" P83653 belongs to the inhibitor cystine-knot family Not found Acrocinus longimanus (Giant harlequin beetle) "Antimicrobial, Antifungal" Protein level Beta strand (3 strands; 8 residues) "Alo-3 contains six cysteine residues forming three disulfide bridges. It exhibits all the structural features characteristic of the knottin fold, namely, a triple-stranded antiparallel beta-sheet with a long flexible loop connecting the first strand to the second strand and a series of turns." 1Q3J resolved by NMR. "Function: Alo-3 shows a level of activity significantly higher against C. glabrata than Alo-1 or Alo-2. Domain: The presence of a disulfide through disulfide knot' structurally defines this protein as a knottin. PTM: Contains three disulfide bonds 1-18; 8-22; 17-33." "Fungi: Candida glabrata patient 1 (MIC=8 ?g/mL), C. glabrata ATCC 90030 (MIC=16 ?g/mL), C. albicans IHEM 8060 (MIC=16 ?g/mL), C. albicans ATCC 36082 (MIC=8 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys1 and Cys18; Cys8 and Cys22; Cys17 and Cys33. L No cytotoxicity information found Not found 14661954 Biochemistry. 2003 Dec 16;42(49):14434-14442. "Barbault F, Landon C, Guenneugues M, Meyer JP, Schott V, Dimarcq JL, Vovelle F." Solution structure of Alo-3: a new knottin-type antifungal peptide from the insect Acrocinus longimanus. DRAMP01623 LIGPVLGLVGSALGGLLKKI 20 "Bombinin-H4 (bombinin H isomers; Frogs, amphibians, animals)" P82284 Belongs to the bombinin family Not found Bombina variegata (European frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, hemolytic against mammalian cells, Antifungal" Protein level Alpha helix "The epimerization reaction is incomplete, or, after racemization, the peptides still containing the L-amino acid in position 2 are partly degraded." None Function: Have antimicrobial activity. Have some hemolytic activity. [Ref.8223491] Gram-negative bacterium: Escherichia coli D21 (MIC=4.8 ?M);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.3 ?M). [Ref.8223491] Lethal concentration is 14.6 ?M against human red blood cell. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8223491 EMBO J. 1993; 12:4829-4832. "Mignogna G, Simmaco M, Kreil G, Barra D.1993" Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata. DRAMP02802 AREASKSLIGTASCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR 46 "Paneth cell-specific alpha-defensin 1 (DEFA1; horse defensin; houses, mammals, animals" A6YB85 Not found DEFA1 Equus caballus (Horse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found 2MXQ resolved by NMR. Function: Membrane permeabilization is at least an essential part of the peptide's mode of action. "Gram-negative bacteria: Escherichia coli [ATCC 11775 (MBC=0.4 ?M); ATCC 25922 (MBC=0.4 ?M); ATCC 35218 (MBC=0.4 ?M)], E. coli D31 (MBC=0.8 ?M), Pseudomonas aeruginosa ATCC 11440 (MBC=3 ?M);##Gram-positive bacteria: Staphylococcus aureus [ATCC 6538 (MBC=0.8 ?M); ATCC 12600 (MBC=1.5 ?M)], Staphylococcus epidermidis ATCC 14990 (MBC=1.5 ?M), Enterococcus faecalis ATCC 29212 (MBC=6.1 ?M), E. faecalis PEG 205 (wild-type) (MBC=3 ?M), Streptococcus pyogenes ATCC 12344 (MBC=0.8 ?M), Bacillus megaterium ATCC 14581 (MBC=0.2 ?M).##Yeast: Candida albicans ATCC 24433 (MIC=0.8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys14 and Cys44; Cys16 and Cys32; Cys22 and Cys43. L No cytotoxicity information found Not found 17620056 Biochem J. 2007 Oct 15;407(2):267-276. "Bruhn O, Regenhard P, Michalek M, Paul S, Gelhaus C, Jung S, Thaller G, Podschun R, Leippe M, Gr?tzinger J, Kalm E." "A novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function." DRAMP02809 HPHVCTSYYCSKFCGTAGCTRYGCRNLHRGKLCFCLHCSR 40 "Myticin-B (Myt B; Cys-rich; molluscas, animals)" P82102 Not found Not found Mytilus galloprovincialis (Mediterranean mussel) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Rich Not found None "Function: Bacteriolytic activity against Gram-positive bacteria and Gram-negative bacteria. Also possesses antifungal activity against F. oxysporum. PTM: contains four disulfide bonds." "Gram-positive bacteria: Micrococcus luteus (MBC=1-2 ?M), Bacillus megaterium (MBC=1-2 ?M), Aerococcus viridans (MBC=2-4 ?M).##Gram-negative bacteria: Escherichia coli D31 (MBC=20-10 ?M).##Fungi: Fusarium oxysporum (MIC=5-10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free contains four disulfide bonds. L No cytotoxicity information found Not found 10491159 Eur J Biochem. 1999 Oct 1;265(1):71-78. "Mitta G, Hubert F, No?l T, Roch P." "Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis." DRAMP01381 GLFTLIKGAAKLIGKTVPKKQARLGMNLWLVKLPTNVKT 39 "Odorranain-K1 (OdK1; Frogs, amphibians, animals)" A6MBN8 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-K1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 g/ml), Bacillus subtilis (MIC=1.10 g/ml).##Yeast: Candida albicans (MIC=1.10 g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01383 ATAWDFGPHGLLPIRPIRIRPLCGKDKS 28 "Odorranain-M1 (OdM1; Frogs, amphibians, animals)" A6MBP6 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Not found None Function: Odorranain-M1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=9.37 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 g/ml), Bacillus subtilis (MIC=75 g/ml).##Yeast: Candida albicans (MIC=18.75 g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02841 RQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIK 34 Lumbricin I(6C34) O96447 Not found Not found Synthetic construct (derived from residues 6C34 of lumbricin I) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Lumbricin I(6-34) has marginally stronger antimicrobial activities than lumbricin I. Has weak hemolytic activity when tested against human erythrocytes. "[Ref.9784609]Gram-positive bacteria: Bacillus subtilis ATCC 62037 (MIC=8 ?g/ml), Staphylococcus aureus ATCC 15752 (MIC=12 ?g/ml), Streptococcus mutans ATCC 25175 (MIC=20 ?g/ml);##Gram-negative bacteria: Escherichia coli ATCC 27325 (MIC=8 ?g/ml), Pseudomonas putidaATCC 17426 (MIC=12 ?g/ml), Serratia sp. ATCC 21074 (MIC=12 ?g/ml).##Fungi: Candida albicans ATCC 10231 (MIC=12 ?g/ml), Cryptococcus neoformance ATCC 34881 (MIC=16 ?g/ml), Saccharomyces cerevisiae ATCC 44774 (MIC=8 ?g/ml).##NOTE: Minimal inhibitory concentrations were determined by incubating approximately 104C105 CFU/ml of cells with serial dilutions of each peptide in a 96-well microtiter plate.." "[Ref.9784609]0.03% hemolytic activity at 5 g/ml, 0.07% hemolytic activity at 10 g/ml, 0.13% hemolytic activity at 25 g/ml, 0.17% hemolytic activity at 50 g/ml, 0.21% hemolytic activity at 100 g/ml against human erythrocytes" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784609 Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76. "Cho JH, Park CB, Yoon YG, Kim SC." "Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization." DRAMP02854 GGLRSLGRKILRAWKKYGPIIVPIIRIG 28 Cathelicidin-5 (Antibacterial peptide BMAP-28; Myeloid antib "P54229, A5PJ96, B9UKL6" Belongs to the cathelicidin family CATHL5 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. PTM: Contains two disulfide bonds. (By similarity)" "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), E. coli ML35 (MIC=2 ?M), E. coli D21 (MIC=0.5 ?M), Salmonella typhimurium ATCC 14028 (MIC=1 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Staphylococcus aureus (MRSA) (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=8 ?M), Cryptococcus neoformans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461##8706679 J Biol Chem. 1996 Nov 8;271(45):28375-28381.##Eur J Biochem. 1996 Jun 15;238(3):769-776. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.##Storici P, Tossi A, Lenarcic B, Romeo D." "Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.##Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides." DRAMP02855 GRFKRFRKKFKKLFKKLSPVIPLLHLG 27 "Cathelicidin-6 (Antibacterial peptide BMAP-27, Myeloid antib" "P54228, B9UKM5" Belongs to the cathelicidin family CATHL6 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (2 helices; 19 residues) Not found 2KET resolved by NMR. "Function: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. PTM: Contains two disulfide bonds. (By similarity)" "Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=1 ?g/ml), E. coli ML35 (MIC=1 ?g/ml), E. coli D21 (MIC=0.25 ?g/ml), Salmonella typhimurium ATCC 14028 (MIC=1 ?g/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?g/ml), Serratia marcescens ATCC 8100 (MIC=2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?g/ml), Staphylococcus aureus Cowan 1 (MIC=2 ?g/ml), Staphylococcus aureus (MRSA) (MIC=4 ?g/ml), S. epidermidis ATCC 12228 (MIC=1 ?g/ml), Bacillus megaterium Bm11 (MIC=2 ?g/ml).##Fungi: Candida albicans (MIC=8 ?g/ml), Cryptococcus neoformans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461##19136450##PubMed ID is not available J. Biol. Chem. 1996;271:28375-28381.##J. Hered. 2009;100:241-245.##To be Published "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M.##Gillenwaters EN, Seabury CM, Elliott JS, Womack JE.##Yang S, Jung H, Kim J." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.##Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.##solution structure of BMAP-27. DRAMP02872 GRFKRFRKKFKKLFKKLS 18 "Myeloid antimicrobial peptide BMAP-27 (1-18) (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 ?M), Escherichia coli ML35 (MIC=4 ?M), Escherichia coli D21 (MIC=4 ?M), Salmonella typhimurium ATCC 14028 (MIC=4 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=2 ?M), Staphylococcus aureus (MRSA) (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=16 ?M), Cryptococcus neoformans (MIC=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461 J Biol Chem. 1996 Nov 8;271(45):28375-28381. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. DRAMP02873 GGLRSLGRKILRAWKKYG 18 "Myeloid antimicrobial peptide BMAP-28 (1-18) (mammals, animals)" No entry found Not found Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Also has antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=0.5 ?M), Escherichia coli D21 (MIC=0.5 ?M), Salmonella typhimurium ATCC14028 (MIC=2 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=1 ?M), Serratia marcescens ATCC 8100 (MIC=2 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), Staphylococcus aureus Cowan 1 (MIC=1 ?M), Staphylococcus aureus (MIC=4 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=2 ?M).##Fungi: Candida albicans (MIC=16 ?M), Cryptococcus neoformans (MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8910461 J Biol Chem. 1996 Nov 8;271(45):28375-28381. "Skerlavaj B, Gennaro R, Bagella L, Merluzzi L, Risso A, Zanetti M." Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. DRAMP02875 LPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQ 76 "Vasostatin-1 (VS-1; N-terminal fragment of Chromogranin-A; mammals, animals)" "P05059, P79392, Q2KJ52" Belongs to the chromogranin/secretogranin protein family CHGA Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None "Function: Vasostatin-1 has antibacterial activity against Gram-positive bacteria M. luteus, B. megaterium. Possesses antifungal activity against N. crassa, A. fumigatus, A. brassicicola, N. hematococca, F. culmorum and F. oxyporum and against the yeast S. cerevisiae and C. albicans. Miscellaneous: Binds calcium with a low-affinity." "Gram-positive bacteria: Micrococcus luteus (MIC=2 ?M), Bacillus megaterium (MIC=0.2 ?M).##Fungi: Neurospora crassa (MIC=3 ?M), Aspergillus fumigatus (MIC=5 ?M), Alternaria brassicicola (MIC=3 ?M), Nectria haematococca (MIC=1 ?M), Fusarium culmorum (MIC=1 ?M), F. oxyporum (MIC=10 ?M), Saccharomyces cerevisiae (MIC=10 ?M), Candida albicans (MIC=10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Binds calcium with a low-affinity. 10753865 J Biol Chem. 2000 Apr 14;275(15):10745-10753. "Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH." "Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A." DRAMP02878 NPVSCVRNKGICVPIRCPGSMKQIGTCVGRAVKCCRKK 38 "Tracheal antimicrobial peptide (TAP; mammals, animals)" "P25068, O97532" Belongs to the beta-defensin family (LAP/TAP subfamily) Not found Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity in vitro. In addition, the peptide is active against Candida albicans, indicating a broad spectrum of activity. Tissue specificity: Tracheal epithelium. PTM: Contains three disulfide bonds 5-34; 12-27; 17-35. (By similarity)" "Gram-negative bacteria: Escherichia coli D31 (MIC=12-25 ?g/ml), Klebsiella pneumoniae 13883 (MIC=12-25 ?g/ml), Pseudomonas aeruginosa 27853 (MIC=25-50 ?g/ml).##Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=25-50 ?g/ml).##Fungi: Candida ablicans (MIC=6-12 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2023943##8506305 Proc Natl Acad Sci U S A. 1991 May 1;88(9):3952-3956.##Proc Natl Acad Sci U S A. 1993 May 15;90(10):4596-4600. "Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL.##Diamond G, Jones DE, Bevins CL." "Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.##Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene." DRAMP02912 RGLRRLGRKIAHGVKKYGPTVLRIIRIAG 29 "SMAP-29 (Cathelin-related peptide SC5; Myeloid antibacterial peptide MAP-29; mammals, animals)" "P49928, P49929" Belongs to the cathelicidin family Not found Ovis aries (Sheep) "Antimicrobial, Antibacterial, Antifungal" Protein level Alpha helix Not found 1FRY resolved by NMR. "Function: Broad spectrum bactericidal agent. Biophysicochemical properties: Temperature dependence (Thermostable)." "[Ref.8549789][No NaCl]: Escherichia coli DH5a (MIC=0.1 ?M), Escherichia coli ML-35p (MIC=0.18 ?M), Pseudomonas aeruginosa PAO1 (MIC=0.17 ?M), Pseudomonas aeruginosa MR3007 (MIC=0.34 ?M), Staphylococcus aureus ATCC (MRSA) 33591 (MIC=1.24 ?M), Staphylococcus aureus 93918 (MIC=0.31 ?M).##[100 mM NaCl]: Escherichia coli DH5a (MIC=0.07 ?M), Escherichia coli ML-35p (MIC=0.12 ?M), Pseudomonas aeruginosa PAO1 (MIC=0.08 ?M), Pseudomonas aeruginosa MR3007 (MIC=0.18 ?M), Staphylococcus aureus ATCC (MRSA) 33591 (MIC=0.65 ?M), Staphylococcus aureus 93918 (MIC=0.43 ?M)." [Ref.8549789]Not found Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Outer membrane protein I (OprI) 8549789##11932493 FEBS Lett. 1995 Dec 27;377(3):519-522.##Protein Eng. 2002 Mar;15(3):225-232. "Mahoney MM, Lee AY, Brezinski-Caliguri DJ, Huttner KM.##Sawai MV, Waring AJ, Kearney WR, McCray PB Jr, Forsyth WR, Lehrer RI, Tack BF." Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide.##Impact of single-residue mutations on the structure and Function: of ovispirin/novispirin antimicrobial peptides. DRAMP02922 KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPK 34 "Canine beta-defensin (dogs, mammals, animals)" No entry found Not found Not found Canis lupus familiaris (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Shows antibacterial activity against Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli 25922 (MIC=20 ?g/ml), Escherichia coli 700336 (MIC=50 ?g/ml);##Gram-positive bacteria: Klebsiella pneumoniae 10031 (MIC=20 ?g/ml), Listeria monocytogenes 19115 (MIC=10 ?g/ml), Staphylococcus aureus 10832 (MIC=100 ?g/ml), N. gonorrhoeae 10150 (MIC=50 ?g/ml).##Fungi: Candida albicans 14053 (MIC=50 ?g/ml), Candida albicans 11006 (MIC=5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15845463 Infect Immun. 2005 May;73(5):2611-2620. "Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T." Molecular cloning and characterization of three beta-defensins from canine testes. DRAMP02923 KCWNLRGSCREKCIKNEKLYIFCTSGKLCCLKPKFQPNMLQR 42 "cBD-1 (Canine beta-defensin 1; dogs, mammals, animals)" No entry found Not found Not found Canis Lupis (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Listeria monocytogenes(MIC=6 m?g/ml), Staphylococcus aureus (MIC=100 m?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=20-25 m?g/ml), Klebsiella pneumoniae (MIC=20 m?g/ml), Neisseria gonorrhoeae (MIC=50 m?g/ml).##Yeast: Candida albicans (MIC=5-50 m?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15845463 Infect Immun. 2005 May;73(5):2611-2620. "Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T." Molecular cloning and characterization of three beta-defensins from canine testes. DRAMP02925 RLKELITTGGQKIGEKIRRIGQRIKDFFKNLQPREEKS 38 "Cathelicidin (dogs, mammals, animals)" No entry found Not found Not found Canis lupus familiaris (Dog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli (MIC=1.25 ?M), Klebsiella pneumoniae (MIC=1.25 ?M), Salmonella serotype Typhimurium (MIC=1.25 ?M), Pseudomonas aeruginosa (MIC=1.25 ?M), Proteus mirabilis (MIC=1.25 ?M), Salmonella serotype Enteritidis (MIC=0.5 ?M), Neisseria gonorrhoeae (MIC=0.06 ?M).##Gram-positive bacteria: Listeria monocytogenes (MIC=0.5 ?M), Staphylococcus aureus (MIC=50 ?M).##Fungi: Candida albicans (MIC=12.5-50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17462733 Dev Comp Immunol. 2007;31(12):1278-1296. "Sang Y, Teresa Ortega M, Rune K, Xiau W, Zhang G, Soulages JL, Lushington GH, Fang J, Williams TD, Blecha F, Melgarejo T." "Canine cathelicidin (K9CATH): gene cloning, expression, and biochemical activity of a novel pro-myeloid antimicrobial peptide." DRAMP02933 RRWCFRVCYRGFCYRKCR 18 "Polyphemusin-1 (PM1; crabs, Arthropods, animals)" P14215 Belongs to the tachyplesin/polyphemusin family Not found Limulus polyphemus (Atlantic horseshoe crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand (2 strands; 4 residues) "The solution structure of polyphemusin I is determined using (1)H-NMR spectroscopy. Polyphemusin I is found to be an amphipathic, beta-hairpin connected by a type I' beta-turn." 1RKK resolved by NMR. "Function: PM1 showes high antimicrobial activity against the Gram-negative, Gram-positive and fungal specimens tested. Tissue specificity: Hemocytes. PTM: Contains two disulfide bonds 4-17; 8-13 and C-terminal amidation." "Gram-negative bacteria: Escherichia coli UB1005 (MIC=0.5 ?g/ml), E. coli DC2 (MIC=1 ?g/ml), Salmonella typhimurium (defensin-sensitive) (MIC=0.25 ?g/ml), S. typhimurium (MIC=1 ?g/ml), Pseudomonas aeruginosa K799 (MIC=2 ?g/ml), P. aeruginosa Z61 (MIC=1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=1 ?g/ml), Enterococcus faecalis (MIC=1 ?g/ml).##Yeasy: Candida albicans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Amidation "Disulfide bond between Cys4 and Cys17,Cys8 and Cys13." L No cytotoxicity information found Not found 2514185##15134657 J Biochem. 1989 Oct;106(4):663-668.##Biochim Biophys Acta. 2004 May 6;1698(2):239-250. "Miyata T, Tokunaga F, Yonega T, Yoshikawa K, Iwanaga S, Niwa M, Takao T, Shimonishi Y.##Powers JP, Rozek A, Hancock RE." "Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity.##Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I." DRAMP02934 RRWSFRVSYRGFSYRKSR 18 PM1-S (linear derivative of PM1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic No secondary structure (CD) "The CD spectra of PM1-S indicates that, in all environments (phosphate buffer, TFE, and liposomes), the peptide displays no observable patterns that could be related to structural features. This indicates that PM1-S is a flexible molecule with no favoured conformation." None Function: PM1-S remaines active against Gram-negative bacteria but displayed poor activity to both Gram-positive and fungal microorganisms. "Gram-negative bacteria: Escherichia coli UB1005 (MIC=4 ?g/ml), E. coli DC2 (MIC=4 ?g/ml), Salmonella typhimurium (defensin-sensitive) (MIC=2 ?g/ml), S. typhimurium (MIC=8 ?g/ml), Pseudomonas aeruginosa K799 (MIC=32 ?g/ml), P. aeruginosa Z61 (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=32 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeasy: Candida albicans (MIC=64 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15134657 Biochim Biophys Acta. 2004 May 6;1698(2):239-250. "Powers JP, Rozek A, Hancock RE." Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I. DRAMP02951 MARVSLLLIVLSIALVAPSQGFLKDLLFGEAKTALLEDGTTEILDHVCNFRVMPRLRSWELYFRGDVWCPGWTVIKGESL 80 "PtALF6 (Portunus trituberculatus anti-lipopolysaccharide factor isoform 6; crabs, Arthropods, ani" No entry found Not found Not found Portunus trituberculatus (Swimming Crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Contains a signal peptide and an LPS-binding Domain: (CNFPVMPRLRSWELYFRGDVWC) and two conserved cysteine residues which can form a disulfide bridge. "Gram-negative bacteria: Vibrio alginolyticus L59 (MIC=1.17-2.33 ?M), Pseudomonas aeruginosa P25 (MIC=9.32-18.64 ?M);##Gram-positive bacteria: Micrococcus luteus M2 (MIC=9.32-18.64 ?M), Staphylococcus aureus S7 (MIC=9.32-18.64 ?M).##Fungi: Pichia pastoris GS115 (MIC>74.57 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 21362485##23257203 Fish Shellfish Immunol. 2011 Jul;31(1):29-42.##Fish Shellfish Immunol. 2013 Feb;34(2):463-470. "Liu Y, Cui Z, Song C, Wang S, Li Q.##Liu Y, Cui Z, Li X, Song C, Shi G." Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus.##A newly identified anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus with broad spectrum antimicrobial activity. DRAMP02956 SHQDCYEALHKCMASHSKPFSCSMKFHMCLQQQ 33 Dolabellanin B2 P83376 Not found Not found Dolabella auricularia (Sea hare) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity against Gram-negative bacteria and Gram-positive bacteria. Also possesses antifungal activity. PTM: Contains two disulfide bonds. Up to two of the methionines may be oxidized to methionine sulfoxides." "Gram-positive bacteria: Bacillus subtilis RIMD0225014 (MIC=2.5 ?g/ml), Staphylococcus aureus IID1677 (MRSA) (MIC=20.0 ?g/ml), Listeria monocytogenes VIU206 (MIC=40.0 ?g/ml).##Gram-negative bacteria: Haemophilus influenzae IID983 (MIC=5.0 ?g/ml), V. vulnificus RIMD2219009 (MIC=5.0 ?g/ml), Escherichia coli JM109 (MIC=20.0 ?g/ml), E. coli DH5? (MIC=40.0 ?g/ml).##Fungi: Candida albicans ATCC36232, Candida tropicalis TIMM0313, S. pombe IFO1628, Saccharomyces cerevisiae A581A." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Contains two disulfide bonds. Up to two of the methionines may be oxidized to methionine sulfoxides. L No cytotoxicity information found Not found 12590964 Dev. Comp. Immunol. 2003;27:305-311. "Iijima R, Kisugi J, Yamazaki M." A novel antimicrobial peptide from the sea hare Dolabella auricularia. DRAMP02228 SMLSVLKNLGKVGLGFVACKINKQC 25 "RANATUERIN 1 (Frogs, amphibians, animals)" P82741 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None Function: Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. Has activity against C.albicans. Has no detectable hemolytic activity. [Ref.9784389] Gram-positive bacterium: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Yeast: Candida albicans (MIC=70 ?M). [Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20?g/ml against human red blood cell. Cyclic Free Cyclization (Cys19 and Cys25) Disulfide bond between Cys19 and Cys25. L No cytotoxicity information found Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02963 GRFRRLRKKTRKRLKKIGKV 20 PMAP-36(1-20) No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6 ?M), Bacillus megaterium Bm11 (MIC=3 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12 ?M), E. coli ML35 (MIC=12 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=48 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=3 ?M).##Fungi: Candida albicans c.i. (MIC>64 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02964 GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLG 34 PMAP-36(1-34) No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1 ?M), S. aureus 710A (MIC=2 ?M), S. aureus SA-62 (MRSA) (MIC=4 ?M), Bacillus megaterium Bm11 (MIC=1 ?M), S. epidermidis ATCC 12228 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), E. coli ML35 (MIC=1 ?M), E. coli D21 (MIC=1 ?M), E. coli D22 (MIC=0.5 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 ?M), S. enterica ser. Enteritidis H2 (MIC=1 ?M), P. aeruginosa ATCC 27853 (MIC=1 ?M), S. marcescens ATCC 8100 (MIC=2 ?M).##Fungi: Candida albicans c.i. (MIC=8 ?M), Cryptococcus neoformans c.i.(MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02965 GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLGC 35 PMAP-36(1-35)2 No entry found Not found Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Exerts antimicrobial activity against both Gram-positive and negative bacteria. "Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 ?M), S. aureus 710A (MIC=2 ?M), S. aureus SA-62 (MRSA) (MIC=4 ?M), Bacillus megaterium Bm11 (MIC=1 ?M), S. epidermidis ATCC 12228 (MIC=1 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), E. coli ML35 (MIC=0.5 ?M), E. coli D21 (MIC=0.5 ?M), E. coli D22 (MIC=0.5 ?M), S. enterica ser. Typhimurium ATCC 14028 (MIC=1 ?M), S. enterica ser. Enteritidis H2 (MIC=0.5 ?M), P. aeruginosa ATCC 27853 (MIC=1 ?M), S. marcescens ATCC 8100 (MIC=2 ?M).##Fungi: Candida albicans c.i. (MIC=16 ?M), Cryptococcus neoformans c.i.(MIC=2 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16128809 FEBS J. 2005 Sep;272(17):4398-4406. "Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A." Structural aspects and biological properties of the cathelicidin PMAP-36. DRAMP02975 VRRFPWWWPFLRR 13 "Tritrpticin (Trp-rich; pigs, mammals, animals)" No entry found Belongs to the cathelicidin family Not found Sus scrofa (Pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix (1 helices; 3 residues) Not found 1D6X resolved by NMR. Function: Tritrpticin has strong antimicrobial activity with a wide spectrum. "Gram-negative bacteria: Escherichia coli (5 mm), Pseudomonas aeruginosa (3 mm), Klebsiella pneumonia (7 mm), Proteus mirabilis (1 mm);##Gram-positive bacteria: Staphylococcus epidermidis (5 mm), Streptococcus group D (4 mm). [inhibit zones in mm]##Fungi: Aspergillus fumigatus (MIC=250 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8706838##10606506 FEBS Lett. 1996 Jul 15;390(1):95-98.##Biochemistry. 1999 Dec 21;38(51):16749-55. "Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K.Schibli DJ, Hwang PM, Vogel HJ.##Schibli DJ, Hwang PM, Vogel HJ." Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides.##Structure of the antimicrobial peptide tritrpticin bound to micelles: a distinct membrane-bound peptide fold. DRAMP02980 GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE 78 "Antimicrobial peptide NK-lysin (NKL; pigs, mammals, animals)" Q29075 Not found NKL Sus scrofa (Pig) "Antimicrobial, Antibacterial, Antifungal, Antitumor" Protein level Alpha helix Not found 1NKL resolved by NMR. "Function: May be an effector molecule of cytotoxic activity. High activity against E. coli and B. megaterium, moderate against A. calcoaceticus and S. pyogenes. Has some antifungal activity against Candida albicans. Tissue specificity: Cytotoxic T and NK cells. Induction: By interleukin-2. PTM: Contains three disulfide bonds 4-76; 7-70; 35-45." "[with medium E]: Escherichia coli D21 (MIC=0.5 ?M), Escherichia coli Bd2221/75 (MIC=10 ?M), Acinetobacter calcoaceticus Ac 11 (MIC=7 ?M), Bacillus megaterium Bmll (MIC=1.6 ?M);##[without medium E]: Escherichia coli D21 (MIC=8 ?M), Escherichia coli Bd2221/75 (MIC=39 ?M), Bacillus megaterium Bmll (MIC=0.8 ?M), Streptococcus pyogenes w.t. (MIC=34 ?M), Candida albicans w.t. (MIC=31 ?M)." [Ref.7737114] It exhibits no hemolytic activity at 170 ?M against sheep red blood cells. Cyclic Free Free Disulfide bonds between Cys4 and Cys76; Cys7 and Cys70; Cys35 and Cys45. L "[Ref.7737114] NK-lysin at 50g/ml was able to give 90% lysis of 5'Cr-labelled YAC-1 cells in a medium with 2% fetal calf serum(FCS) and 75% lysis in phosphate-buffered saline(PBS), 15% lysis suspended in medium E." Lipopolysaccharide (LPS)-binding 7737114##9334742 EMBO J. 1995 Apr 18;14(8):1615-1625.##Nat Struct Biol. 1997 Oct;4(10):793-795. "Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, J?rnvall H, Mutt V, Olsson B, Wigzell H, et al.##Liepinsh E, Andersson M, Ruysschaert JM, Otting G." "NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.##Saposin fold revealed by the NMR structure of NK-lysin." DRAMP01377 FMPILSCSRFKRC 13 "Odorranain-G1 (OdG1; Frogs, amphibians, animals)" "A6MBL7, A6MBL8" Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-" Transcript level Not found Odorranain-G1 adopts 44.1% -sheet structure in water solution. None Function: Odorranain-G1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.68 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 g/ml), Bacillus subtilis (MIC=37.5 g/ml).##Yeast: Candida albicans (MIC=1.10 g/ml)." [Ref:17272268] It has no hemolytic activity against rabbit red blood cells Cyclic Free Cyclization (Cys7 and Cys13) Disulfide bond between Cys7 and Cys13. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP02999 PFKISIHL 8 "Jellein-1 (Jelleine-I; chain of Major royal jelly protein 1; Insects, animals)" "O18330, Q548D6" Belongs to the major royal jelly protein family MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-1 has antibacterial and antifungal activity. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. Developmental stage: Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee. Miscellaneous: Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival. Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days. PTM: Histidine amide at H7." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=10 ?g/ml), S. saprophyticus (MIC=15 ?g/ml), Bacillus subtilis CCT 2471 (MIC=10 ?g/ml).##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=2.5 ?g/ml), Enterobacter cloacae ACCT 23355 (MIC=10 ?g/ml), Klebsiella pneumoniae ACCT 13883 (MIC=10 ?g/ml), Pseudomonas aeruginosa ACCT 27853 (MIC=10 ?g/ml).##Yeast: Candida albicans (MIC=2.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237##9395329##21516106 Peptides. 2004 Jun;25(6):919-928.##Eur J Biochem. 1997 Nov 1;249(3):797-802.##Nature. 2011 May 26;473(7348):478-483. "Fontana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS.##Ohashi K, Natori S, Kubo T.##Kamakura M." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).##Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.##Royalactin induces queen differentiation in honeybees. DRAMP03000 TPFKISIHL 9 "Jellein-2 (Jelleine-II; chain of Major royal jelly protein 1; Insects, animals)" "O18330, Q548D6" Belongs to the major royal jelly protein family MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-2 has antibacterial and antifungal activity. Jellein-2 is probably processed to yield jellein-1 and jellein-4. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. Developmental stage: Produced in the cephalic glands of both the nurse bee and the forager bee. This bee milk protein changes to alpha-glucosidase in accordance with the age-dependent role change of the worker bee. Miscellaneous: Exhibits a growth factor-like action on primary-cultured rat hepatocytes by stimulating DNA synthesis and protecting cells from apoptosis induced by serum deprivation. Also activates mitogen-activated protein kinase, as well as protein kinase B, a key regulator of cell survival. Degraded proportionally to the period of storage, and is completely lost during storage at 40 degrees Celsius for 30 days. PTM: Leucine amide at L9." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=15 ?g/ml), S. saprophyticus (MIC=10 ?g/ml), Bacillus subtilis CCT 2471 (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT 1371 (MIC=15 ?g/ml), Enterobacter cloacae ACCT 23355 (MIC=15 ?g/ml), Klebsiella pneumoniae ACCT 13883 (MIC=15 ?g/ml), Pseudomonas aeruginosa ACCT 27853 (MIC=15 ?g/ml).##Yeast: Candida albicans (MIC=2.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237##9395329##21516106 Peptides. 2004 Jun;25(6):919-928.##Eur J Biochem. 1997 Nov 1;249(3):797-802.##Nature. 2011 May 26;473(7348):478-483. "Fontana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS.##Ohashi K, Natori S, Kubo T.##Kamakura M." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).##Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.##Royalactin induces queen differentiation in honeybees. DRAMP03001 EPFKISIHL 9 "Jellein-3 (Jelleine-III; Insects, animals)" P84759 Not found MRJP1 Apis mellifera (Honeybee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Jellein-3 has antibacterial and antifungal activity. Tissue specificity: Found in the hypopharyngeal glands of the worker honeybee. PTM: Leucine amide at L9." "Gram-positive bacteria: Staphylococcus aureus ATCC 6535 (MIC=30 ?g/ml), S. saprophyticus (MIC=30 ?g/ml);##Gram-negative bacteria: Escherichia coli CCT1371 (MIC=15 ?g/ml), Enterobacter cloacae ATCC 23355, Klebsiella pneumoniae ATCC 13883, Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?g/ml).##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203237 Peptides. 2004 Jun;25(6):919-928. "ntana R, Mendes MA, de Souza BM, Konno K, Csar LM, Malaspina O, Palma MS." Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera). DRAMP03057 GSKKPVPIIYCNRRTGKCQRM 21 "Thanatin(insects, arthropods, invertebrates, animals)" P55788 Not found Not found Podisus maculiventris "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand "Contain C-terminally a loop of 6 residues, delineated by an intramolecular disulfide bridge. This loop carries a strong positive charge in both molecules and contains a central threonine residue, which separates two subgroups of electropositivity." 8TFV Function: Insect defense peptide with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and fungi. No activity against S.aureus. Stops respiration in bacteria but does not permeabilize their inner membranes. Has no detectable hemolytic activity. "[Ref.8577744] Gram-positive bacteria: Aerococcus viridans (MIC=0.6-1.2 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Bacillus subtilis (MIC=2.5-5 ?M), Pediococcus acidilactici (MIC=20-40 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.3-0.6 ?M), Escherichia coli D31 (MIC=0.3-0.6 ?M), Escherichia coli 1106 (MIC=0.6-1.2 ?M), Salmonella typhimurium (MIC=0.6-1.2 ?M), Klebsiella pneumoniae (MIC=0.6-1.2 ?M), Enterobacter cloacae (MIC=1.2-2.5 ?M), Erwinia carotovora (MIC=10-20 ?M), Pseudomonas aeruginosa (MIC=20-40 ?M);##Fungi: Neurospora crassa (MIC=0.6-1.2 ?M), Botrytis cinerea (MIC=1.2-2.5 ?M), Nectria haematococca (MIC=1.2-2.5 ?M), Trichoderma viride (MIC=1.2-2.5 ?M), Alternaria brassicicola (MIC=2.5-5 ?M), Fusarium culmorum (MIC=2.5-5 ?M), Ascochyta pisi (MIC=5-10?M), Fusarium oxysporum (MIC=10-20 ?M)." [Ref.8577744] It exhibits no hemolytic activity at 40 ?M against porcine erythrocytes. Cyclic Free Free Disulfide bond between Cys11 and Cys18. L No cytotoxicity information found Not found 8577744##9760181 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.##Eur J Biochem. 1998 Sep 1;256(2):404-410. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA.##Mandard N, Sodano P, Labbe H, Bonmatin JM, Bulet P, Hetru C, Ptak M, Vovelle F." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.##Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data." DRAMP03007 GFLSALKKYLPIVLKHV 17 "Osmin (Insects, animals)" P0CD70 Not found Not found Osmia rufa (Red mason bee) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (CD) "In absence of TFE, the spectrum shows a random coil type structure. When increasing the concentration of TFE from 0 to 20%, a transition into an -helix structure is observed." None "Function: Synthetic peptide exhibits hemolytic activity to human erythrocytes and inhibits bacterial and fungal growth at micromolar concentrations. A synthetic peptide with a free C-terminus shows weaker hemolytic (5.0 HU/mg), antibacterial and antifungal activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." [Ref.19109988]Gram-positive bacterium: Micrococcus luteus (MIC=1.56-0.78 ?M);##Gram-negative bacterium: Escherichia coli SBS363 (MIC=3.125-1.56 ?M);##fungi: Fusarium oxysporum (MIC=0.78-0.39 ?M). [Ref.19109988]5.0 HU/mg hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19109988 Toxicon. 2010 Jan;55(1):20-27. "?cklin R, Favreau P, Thai R, Pflugfelder J, Bulet P, Mebs D." Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (hymenoptera: megachilidae). DRAMP03033 INWKGIAAMAKKLL 14 "Mastoparan-like peptide 12a (Insects, animals)" P0C1M4 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide. Has little hemolytic activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " [Ref.17046111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 ?g/ml);##Fungi: Candida albicans ATCC 2002 (MIC=3.7 ?g/ml). [Ref.16330062]Little hemolytic activity at 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062##17046111 Toxicon. 2006 Feb;47(2):249-253.##Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.##Xu X, Yang H, Yu H, Li J, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom.##The mastoparanogen from wasp. DRAMP03034 INWKGIAAMKKLL 13 "Mastoparan-like peptide 12b (Insects, animals)" P0C1M5 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide. Has little hemolytic activity. Shows antimicrobial activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L13)." [Ref.16330062]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 ?g/ml);##Fungi: Candida albicans ATCC 2002 (MIC=7.5 ?g/ml). [Ref.16330062]Little hemolytic activity at 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. Epub 2005 Dec 5. Peptides. 2006 Dec;27(12):3053-7. Epub 2006 Oct 13. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.Xu X, Yang H, Yu H, Li J, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venomThe mastoparanogen from wasp. DRAMP03035 INLKAIAALAKKLLG 15 "Mastoparan-like peptide 12c (Insects, animals)" A0SPI0 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows mast cell degranulation and antimicrobial activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.0 ?g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=12.0 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17046111 Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Yang H, Yu H, Li J, Lai R." The mastoparanogen from wasp. DRAMP03036 INLKAIAAMAKKLL 14 "Mastoparan-like peptide 12d (Insects, animals)" P0C5G7 Not found Not found Vespa magnifica (Hornet) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Shows mast cell degranulation and antimicrobial activities. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (Leucine amide: L14). " Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=1.5 ?g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=12.0 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17046111 Peptides. 2006 Dec;27(12):3053-3057. "Xu X, Yang H, Yu H, Li J, Lai R." The mastoparanogen from wasp. DRAMP03038 LNLKGLIKKVASLLN 15 "Eumenitin-R (Insects, animals)" P0CJ36 Not found Not found Eumenes rubrofemoratus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=60 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=15 ?M), Streptococcus pyogenes (clinical sample) (MIC=15 ?M), Bacillus subtilis ATCC 6633 (MIC=7.5 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 ?M);##Fungi: Candida albicans ATCC 90112 (MIC<7.5 ?M)." [Ref.21549739]EC50=530.3 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03039 LNLKGLFKKVASLLT 15 "Eumenitin-F (Insects, animals)" P0CJ37 Not found Not found Eumenes fraterculus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC>60 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=30 ?M), Streptococcus pyogenes (clinical sample) (MIC=30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC>60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC=15 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=353.4 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03040 FDVMGIIKKIAGAL 14 "Eumenine mastoparan-EF (EMP-EF; Insects, animals)" P0CJ39 Not found Not found Eumenes fraterculus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC=30 ?M), Streptococcus pyogenes (clinical sample) (MIC>30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=181.1 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03041 FDIMGLIKKVAGAL 14 "Eumenine mastoparan-ER (EMP-ER; Insects, animals)" P0CJ38 Not found Not found Eumenes rubrofemoratus (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide by forming pore in membrane. Has antibacterial activities against both Gram-positive and Gram-negative strains. Has more potent activities against the yeast C.albicans. Shows moderate mast cell degranulation and leishmanicidal activities. Has a very low hemolytic activity against mice erythrocytes. Tissue specificity: Expressed by the venom sac. PTM: C-terminal amidation (Leucine amide: L14)." "[Ref.21549739]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=30 ?M), Staphylococcus epidermidis (clinical sample) (MIC=30 ?M), Micrococcus luteus ATCC 10240 (MIC>30 ?M), Streptococcus pyogenes (clinical sample) (MIC>30 ?M), Bacillus subtilis ATCC 6633 (MIC=30 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30 ?M), Proteus mirabilis (clinical sample) (MIC=60 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC>30 ?M), Stenotrophomonas maltophilia ATCC 13637 (MIC>30 ?M);##Fungi: Candida albicans ATCC 90112 (MIC=7.5 ?M)." [Ref.21549739]EC50=200 M against mice erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane (Note: Assumes an amphipathic alpha-helical conformation in a lipid environmen 21549739 Toxicon. 2011 Jun;57(7-8):1081-1092. "Rangel M, Cabrera MP, Kazuma K, Ando K, Wang X, Kato M, Nihei K, Hirata IY, Cross TJ, Garcia AN, Faquim-Mauro EL, Franzolin MR, Fuchino H, Mori-Yasumoto K, Sekita S, Kadowaki M, Satake M, Konno K." Chemical and biological characterization of four new linear cationic ?-helical peptides from the venoms of two solitary eumenine wasps. DRAMP03045 VTCELLMFGGVVGDSACAANCLSMGKAGGSCNGGLCDCRKTTFKELWDKRFG 52 "Defensin-NV (Insects, animals)" No entry found Not found Not found Nasonia vitripennis (Ectoparasitic wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Bridge Not found None "Function: Defensin-NV had little hemolytic activity to rabbit red blood cells and has antimicrobial activity against Gram-positive, Gram-negative bacteria, and Fungi." "[Ref.20362606]Gram-positive bacteria: Staphylococcus aureus (MIC=0.93 ?M), Bacillus cereus (MIC=0.93 ?M), B. dysenteriae (MIC=0.46 ?M);##Gram-negative bacteria: Escherichia coli (MIC=1.86 ?M), Pseudomonas aeruginosa (MIC=9.3 ?M).##Yeast: Candida albicans (MIC=1.86 ?M)." [Ref.20362606]5% hemolytic activity at 200 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20362606 Toxicon. 2010 Aug 1;56(1):101-106. "Ye J, Zhao H, Wang H, Bian J, Zheng R." A defensin antimicrobial peptide from the venoms of Nasonia vitripennis. DRAMP03046 ILGIITSLLKSL 12 "Orancis-protonectin (chain of Venom peptide 2-long; Venom peptide 2, OdVP2; Insects, animals)" "P86147, C7DT08" Belongs to the MCD family (Protonectin subfamily) VP2 Orancistrocerus drewseni (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None Function: Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations. Also exhibits strong antimicrobial activity against fungi. Venom peptide 2-long has substantially lower antimicrobial activity against C. albicans and bacteria than Orancis-protonectin but has equivalent activity against Botrytis cinerea. "[Ref.19857508]Gram-positive bacteria: Staphylococcus aureus (MIC=25 g/ml);##Fungi: Candida albicans (MIC<100 ?g/ml), Botrytis cinerea (MIC=0.5 ?g/ml)." [Ref.18695936]84% hemolytic activity at 50 M against sheep blood cells. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19857508##18695936 Toxicon. 2010 Apr 1;55(4):711-718.##Amino Acids. 2009 Jul;37(2):389-394. "Baek JH, Lee SH.##Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T." "Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).##Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni." DRAMP03047 EPILGIITSLLKSL 14 "Venom peptide 2-long (OdVP2L; analog of OdVP2; Insects, animals)" "P86147, C7DT08" Belongs to the MCD family (Protonectin subfamily) VP2 Orancistrocerus drewseni (Solitary wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations. Tissue specificity: Expressed by the venom gland." "[Swiss_Prot Entry P86147]Fungi: Botrytis cinerea (MIC=0.5 ?g/ml), Candida albicans (MIC=100 ?g/ml);##Gram-positive bacterium: S. aureus (MIC=25 ?g/ml);##Gram-negative bacterium: Escherichia coli." [Swiss_Prot Entry P86147]has potent hemolytic activity against ovine erythrocytes at micromolar concentrations Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19857508##18695936 Toxicon. 2010 Apr 1;55(4):711-718.##Amino Acids. 2009 Jul;37(2):389-394. "Baek JH, Lee SH.##Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T." "Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).##Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni." DRAMP03056 SLLSLIRKLIT 11 "Decoralin (Insects, animals)" P85870 Not found Not found Oreumenes decoratus (Potter wasp) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Linear cationic alpha-helical peptide that acts as antimicrobial peptide. At high concentrations exhibits activity in stimulating degranulation from rat peritoneal mast cells. Inhibits the growth of L.major promastigotes in vitro with an IC50 of 72 ?M. Has hemolytic activity towards human and mouse erythrocytes. Tissue specificity: Expressed by the venom gland." "[Ref.17981364]Gram-positive bacteria: Staphylococcus aureus CCT 6538 (MIC=40 ?M), S. saprophyticus (MIC=40 ?M), Bacillus subtilis CCT 2471 (MIC=40 ?M), B. thuringiensis (MIC=40 ?M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=80 ?M), Escherichia coli CCT 1371 (MIC=160 ?M), Klebsiella pneumoniae ATCC 13883 (MIC=80 ?M), A. faecalis ATCC 8750 (MIC=40 ?M);##Fungi: Candida albicans (MIC=40 ?M), L. major promastigotes (IC50=72 ?M)." [Ref.17981364]EC50=1 mM against mouse erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 17981364 Peptides. 2007 Dec;28(12):2320-2327. "Konno K, Rangel M, Oliveira JS, Dos Santos Cabrera MP, Fontana R, Hirata IY, Hide I, Nakata Y, Mori K, Kawano M, Fuchino H, Sekita S, Neto JR." "Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus." DRAMP03063 DKLIGSCVWGAVNYTSNCNAECKRRGYKGGHCGSFANVNCWCET 44 "Defensin ARD1 (Heliomicin analogs; Insects, animals)" P84156 Not found Not found Archaeoprepona demophon (One-spotted leafwing butterfly) "Antimicrobial, Antifungal" Protein level Combine helix and strand structure Not found "1OZZ, 1P00, 1P0A resolved by NMR." "Function: Possesses potent anti-fungal activity. PTM: Contains three disulfide bonds 7-32; 18-40; 22-42. " "Fungi: Candida albicans IHEM 8060 (MIC=6.25 ?g/ml), Cryptococcus neoformans A (MIC=12.5 ?g/ml), Aspergillus fumigatus GASP4707 (MIC=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic(CS scaffold (an -helix linked to a -she Free Free Disulfide bonds between Cys7 and Cys32; Cys18 and Cys40; Cys22 and Cys42. L No cytotoxicity information found Not found 14978308 Protein Sci. 2004 Mar;13(3):703-713. "Landon C, Barbault F, Legrain M, Menin L, Guenneugues M, Schott V, Vovelle F, Dimarcq JL." Lead optimization of antifungal peptides with 3D NMR structures analysis. DRAMP03090 GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR 39 "Drosophila cecropin B (CecB; Insects, animals)" "P14956, O16826, O16827, O16828, O18647, O61274, Q9V425" Belongs to the cecropin family CecB Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food. [Ref.1]" "Gram-negative bacteria: Escherichia coli D21 (MIC=1.8 ?M), Enterobacter cloacae b12 (MIC=1.0 ?M), Pseudomonas aeruginosa OT97 (MIC=4.2 ?M);##Gram-positive bacteria: Bacillus megatherium Bm11 (MIC=3.7 ?M), Bacillus subtilis Bsll (MIC=3.2 ?M), Micrococcus luteus MI11 (MIC=59 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2390977##2104802 EMBO J. 1990 Sep;9(9):2969-2976.##EMBO J. 1990 Jan;9(1):217-224. "Samakovlis C, Kimbrell DA, Kylsten P, Engstr?m A, Hultmark D.##Kylsten P, Samakovlis C, Hultmark D." The immune response in Drosophila: pattern of cecropin expression and biological activity.##The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection. DRAMP03096 RRQGPIFDTRPSPFNPNQPRPGPIY 25 "Metchnikowin-2 (Insects, animals)" No entry found Not found Not found Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Micrococcus luteus (MIC=0.5-1.0 ?M).##Fungi: Neurospora crassa (MIC=0.5-1.0 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7588819 Eur J Biochem. 1995 Oct 15;233(2):694-700. "Levashina EA, Ohresser S, Bulet P, Reichhart JM, Hetru C, Hoffmann JA." "Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties." DRAMP18495 QCRRLCYKQRCVTYCRGR 18 "Gomesin (Gm; Spiders, arachnids, Chelicerata, arthropods, invertebrates, animals)" P82358 Belongs to the tachyplesin family Not found Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic, Antimalarial, Antic" Protein level Beta sheet Not found 1KFP resolved by NMR. "Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. It shows hemolytic activity. Tissue specificity: In hemocytes only, but not in all hemocytes observed." "[Ref.10942757] Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 M), Bacillus cereus (MIC=6.25-12.5 M), Bacillus megaterium (MIC=0.2-0.4 M), Bacillus thuringiensis (MIC=1.6-3.15 M), Enterococcus faecalis (MIC=6.2-12.5 M), Listeria monocytogenes (MIC=0.8-1.6 M), Micrococcus luteus (MIC=0.4-0.8 M), Pediococcus acidolacrici (MIC=3.15-6.25 M), Staphylococcus aureus (MIC=1.6-3.15 M), Staphylococcus epidermidis (MIC=0.8-1.6 M), Staphylococcus haemolyticus (MIC=0.8-1.6 M), Staphylococcus saprophyticus (MIC=0.8-1.6 M), Streptococcus pyogenes (MIC=1.6-3.15 M), Nocardia asteroides (MIC=1.6-3.15 M);##Gram-negative bacteria: Escherichia coli 1106 (MIC=0.8-1.6 M), Escherichia coli D22 (MIC=0.4-0.8 M), Escherichia coli D31 (MIC=0.8-1.6 M), Escherichia coli SBS363 (MIC=0.4-0.8 M), Erwinia carolovora (MIC=3.15-6.25 M), Enterobacter cloacae 12 (MIC=3.15-6.25 M), Klebsiella pneumoniae (MIC=3.15-6.25 M), Pseudomonas aeruginosa (MIC=1.6-3.15 M), Salmonella thyphinurium (MIC=0.8-1.6 M), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 M);##Fungi: Alternaria brassicola (MIC=0.4-0.8 M), Aspergillus fumigatus (MIC=1.6-3.15 M), Beauveria bassiana (MIC=12.5-25 M), Fusarium culmorum (MIC=0.4-0.8 M), Fusarium oxysporum (MIC=0.4-0.8 M), Neurospora crassa (MIC=0.4-0.8 M), Nectria haematococca (MIC=0.2-0.4 M), Tricoderma viridae (MIC=0.4-0.8 M), Tricophvton mentagrophytes (MIC=0.8-1.6 M);##Yeasts: Candida albicans (MIC=0.15-0.3 M), Candida glabrata (MIC=12.5-25 M), Candida tropicalis (MIC=3.15-6.25 M), Cryptococcus neoformans (MIC=0.8-1.6 M), Saccharomyces cerevisiae (MIC=1.6-3.15 M)." [Ref.10942757] It exhibits 16% hemolysis at 1 M and 100 M against human erythrocytes Cyclic pyroglutamic acid Amidation "Disulfide bond between Cys2 and Cys15,Cys6 and Cys11." L No cytotoxicity information found Not found 10942757 J Biol Chem. 2000 Oct 27;275(43):33464-70. "Silva PI Jr, Daffre S, Bulet P." "Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family." DRAMP03098 HRHQGPIFDTRPSPFNPNQPRPGPIY 26 "Metchnikowin (Pro-rich; Insects, animals)" "Q24395, Q24396, Q86BV8, Q9V7B9" Not found Mtk Drosophila melanogaster (Common fruit fly) "Antimicrobial, Antibacterial, Antifungal" Protein level Rich in Proline Not found None Transgenic plants: Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens (J Exp Bot. 2009;60(14):4105-14). "Micrococcus luteus (MIC=0.5-1.0 ?g/ml), Neurospora crassa (MIC=0.5-1.0 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7588819 Eur J Biochem. 1995 Oct 15;233(2):694-700. "Levashina E.A, Ohresser S, Bulet P, Reichhart JM, Hetru C, Hoffmann J.A." "Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties." DRAMP03113 SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK 84 "SK84 (Gly-rich; Insects, animals)" No entry found Not found Not found Drosophila virilis (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiviral" Not found Not found Not found None "Function: SK84 displays antibacterial activity against the tested Gram-positive bacteria (B. subtilis, Bacillus thuringiensis and Staphylococcus aureus), but had no effect on Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and fungi (Saccharomyces cerevisiae, Candida albicans). Has weak hemolytic activity." "[Ref.19799950]Gram-positive bacteria: Bacillus thuringiensis ATCC 1041 (MIC=4 ?M), B. subtilis ATCC 9372 (MIC=8 ?M), Staphylococcus aureus ATCC 6538 (MIC=8 ?M)." [Ref.19799950]0.01% hemolytic activity at 100 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19799950 Peptides. 2010 Jan;31(1):44-50. "Lu J, Chen ZW." "Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis." DRAMP03138 GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL 34 "Cecropin-A (Insects, animals)" "P82592, Q17NR3, Q95PI9" Belongs to the cecropin family CECA Aedes aegypti (Yellowfever mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacteria: Escherichia coli D22 (MIC=0.25-0.5 ?g/ml), E. coli D31 (MIC=0.25-0.5 ?g/ml), E. coli SBS363 (MIC=0.1-0.25 ?g/ml), E. coli 1106 (MIC=0.25-0.5 ?g/ml), Enterobacter cloacae b12 (MIC=50-100 ?g/ml), E. carotovora (MIC=0.25-0.5 ?g/ml), Klebsiella pneumoniae (MIC=1-2.5 ?g/ml), Pseudomonas aeruginosa (MIC=10-25 ?g/ml), Salmonella typhimurium (MIC=1-2.5 ?g/ml), X. campestris (MIC=0.5-1 ?g/ml);##Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 ?g/ml), Bacillus megaterium (MIC=1-2.5 ?g/ml), Micrococcus luteus (MIC=10-25 ?g/ml), Streptococcus pyogenes (MIC=10-25 ?g/ml).##Fungi: Fusarium culmorum (MIC=1-2.5 ?g/ml), Fusarium oxysporum (MIC=2.5-5 ?g/ml), Neurospora crassa (MIC=5-10 ?g/ml), Candida albicans (MIC=25-50 ?g/ml), Cryptococcus neoformans (MIC=25-50 ?g/ml), Saccharomyces cerevisiae (MIC=50-100 ?g/ml) " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10400619 J Biol Chem. 1999 Jul 16;274(29):20092-20097. "Lowenberger C, Charlet M, Vizioli J, Kamal S, Richman A, Christensen BM, Bulet P." "Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti." DRAMP03140 GRLKKLGKKIEGAGKRVFKAAEKALPVVAGVKALG 35 "Anopheles cecropin-A amidated isoform (Insects, animals)" "P82290, A7XAX5, A7XAX7, A7XAY1, A7XAY8, A7XAZ7, A7XB12, A7XB23, Q7QEE3" Belongs to the cecropin family CecA Anopheles gambiae (African malaria mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antibacterial activity against several Gram-positive and Gram-negative bacteria. Also has antifungal activity. Tissue specificity: Relatively abundant in head, thorax and to a lesser extent in abdominal carcass and anterior midgut. Developmental stage: In young pupae, expressed within 2 hours of infection and continued to accumulate over 16 hours. Induction: By bacterial infection. PTM: C-terminal amidation." "Gram-negative bacteria: Alcaligenes faecalis (MIC=1-2.5 ?M), Escherichia coli 1106 (MIC=0.5-1 ?M), E. coli D22 (MIC=0.1-0.25 ?M), E. coli D31 (MIC=0.1-0.25 ?M), E. coli SBS363 (MIC=0.05-0.1 ?M), Enterobacter cloacae 12 (MIC=0.5-1 ?M), Erwinia carotovora (MIC=0.5-1 ?M), Klebsiella pneumoniae (MIC=1-2.5 ?M), Pseudomonas aeruginosa (MIC=1-2.5 ?M), Salmonella typhimurium (MIC=0.1-0.25 ?M), Xanthomonas campestris (MIC=0.5-1 ?M); ##Gram-positive bacteria: Aerococcus viridans (MIC=0.5-1 ?M), Bacillus cereus (MIC=50-100 ?M), Bacillus megaterium (MIC=0.5-1 ?M), Listeria monocytogenes (MIC=50-100 ?M), Micrococcus luteus (MIC=0.5-1 ?M), Staphylococcus aureus (MIC=50-100 ?M), Staphylococcus epidermidis (MIC=10-25 ?M), Staphylococcus haemolyticus (MIC=1-2.5 ?M), Staphylococcus saprophyticus (MIC=1-2.5 ?M), Streptococcus pyogenes (MIC=0.1-0.25 ?M).##Fungi: Aspergillus fumigatus (MIC=5-10 ?M), Botrytis cinerea (MIC=1-2.5 ?M), Fusarium culmorum (MIC=0.5-1 ?M), Fusarium oxysporum (MIC=1-2.5 ?M), Neurospora crassa (MIC=1-2.5 ?M), Candida albicans (MIC=1-2.5 ?M), Cryptococcus neoformans (MIC=5-10 ?M), Saccharomyces cerevisiae (MIC=25-50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10672074##12421409 Insect Mol Biol. 2000 Feb;9(1):75-84.##Insect Mol Biol. 2002 Dec;11(6):517-525. "Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, Mller HM, Dimopoulos G, Hoffmann J, Kafatos FC, Richman A.##Zheng XL, Zheng AL." "Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae.##Genomic organization and regulation of three cecropin genes in Anopheles gambiae." DRAMP03150 MVFAYAPTCARCKSIGARYCGYGYLNRKGVSCDGQTTINSCEDCKRKFGRCSDGFITECFL 61 "Gambicin (Insects, animals)" No entry found Not found Not found Anopheles albimanus (mosquito) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic" Not found Bridge Not found None "Function: In vitro experiments showed that the 6.8-kDa mature peptide can kill both Gram-positive and Gram-negative bacteria, has a morphogenic effect on a filamentous fungus, and is marginally lethal to Plasmodium berghei ookinetes. Induction: Predominantly expressed in the anterior part. PTM: Contains four disulfide bridges." Gram-negative bacterium: E. coli (MIC=6.25-12.5 ?M);##Gram-positive bacterium: M. luteus (MIC=25-50 ?M).##Fungus: N. crassa. No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys9 and Cys20; Cys12 and Cys32; Cys41 and Cys51,Cys44 and Cys59." L No cytotoxicity information found Not found 11606751 Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12630-5. "Vizioli J, Bulet P, Hoffmann JA, Kafatos FC, Mller HM, Dimopoulos G." Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae. DRAMP03162 ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR 40 "Phlebotomus duboscqi defensin (PduDef; defensins; Insects, animals)" P83404 Belongs to the invertebrate defensin family (Type 1 subfamily) Not found Phlebotomus duboscqi "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiparasitic" Protein level Bridge Not found None "Function: Has antiparasitic and antifungal activity. Tissue specificity: Is synthesized by the fat body and eventually secreted into the hemolymph. Induction: By bacterial and parasitic hemolymph and gut infections. Expression peaks at 24 hours post infection by bacterium P. carotovorum, and at day four post infection by the parasite L. major. PTM: Problely contains three disulfide bonds 3-30; 16-36; 20-36." "Gram-positive bacteria: Staphylococcus aureus (MIC=0.78-1.56 ?M), Aspergillus fumigatus (MIC=12.5-25 ?M).##Fungi: Fusarium culmorum (MIC=1.56-3.12 ?M), Fusarium oxysporum (MIC=3.12-6.25 ?M), Neurospora crassa (MIC=6.25-12.5 ?M), Trichoderma viride (MIC=3.12-6.25 ?M), Trichophyton mentagrophytes (MIC=25-50 ?M), Candida albicans (MIC=6.25-12.5 ?M), Saccharomyces cerevisiae (MIC=25-50 ?M).##Parasite: Leishmania major promastigote forms (IC50=68-85 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bonds between Cys3 and Cys30; Cys16 and Cys36; Cys20 and Cys36. L No cytotoxicity information found Not found 15557638 Infect Immun. 2004 Dec;72(12):7140-7146. "Boulanger N, Lowenberger C, Volf P, Ursic R, Sigutova L, Sabatier L, Svobodova M, Beverley SM, Sp?th G, Brun R, Pesson B, Bulet P." Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major. DRAMP03166 IRNSLTCRFNFGICLPKRCPGRMRQIGTCF 30 "P15 (deer beta-defensin; ruminant, animals)" No entry found Not found Not found Cervus elaphus (New Zealand deer) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None "Function: It shows strong activity against Gram-negative bacteria, but lesser activity against Gram-positive bacteria and yeast. Caution: the sequence displayed is N-terminal sequence of P15. " Gram-negative bacterium: Escherichia coli O111 (MIC=0.3 ?g/mL);##Gram-positive bacterium: Staphylococcus aureus NCTC 4163 (MIC=1 ?g/mL).##Fungi: Candida albicans 3135A (MIC=3 ?g/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16011891 Int J Antimicrob Agents. 2005 Aug;26(2):165-169. "Treffers C, Chen L, Anderson RC, Yu PL." Isolation and characterisation of antimicrobial peptides from deer neutrophils. DRAMP03173 RWCVYAYVRVRGVLVRYRRCW 21 "Arenicin-1 (Ar-1; marine polychaeta, animals)" "Q5SC60, P84105" Not found Not found Arenicola marina (Lugworm) (Lumbricus marinus) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Cytotoxic" Protein level Beta strand (2 strands; 16 residues) "Arenicin-1 is a two-stranded antiparallel -sheet (Cys3-Val10 and Val13-Cys20) stabilized by nine intra-backbone hydrogen bonds and a disulfide bond between Cys3 and Cys20. The strands of the -sheet are connected by a type I? -turn. The surface of arenicin is amphiphilic, with distinct hydrophobic and hydrophilic areas (ref.2)." 2JSB resolved by NMR. "Function: Has antimicrobial activity against the Gram-negative bacteria, Gram-positive bacteriua as well as yeast C. albicans. Bacterial killing occurs within minutes and is accompanied by membrane permeabilization, membrane detachment and release of cytoplasm. Interaction of arenicin with reconstituted membranes that mimic the lipopolysaccharide-containing outer membrane or the phospholipid-containing plasma membrane of Gram-negative bacteria exhibited no pronounced lipid specificity. PTM: Contains one disulfide bond 3-20. Domian: Contains 1 BRICHOS domain." "Gram-positive bacterium: Listeria monocytogenes EGD (MIC=0.6 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35p (MIC=4 ?g/ml), E. coli WBB01 (MIC=0.3 mM), E. coli ATCC 23716 (MIC=0.6 mM), Salmonella enterica R595 (MIC=0.3 mM), S. enterica R60 (MIC=1.25 mM), Proteus mirabilis R45 (MIC=0.6 mM).##Yeast: Candida albicans 820 (MIC=20 ?g/ml).##Human Jurkat T-cells: LD50>40 mM (35.5% lysis at 30 mM)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Disulfide bond between Cys3 and Cys20. L "[Ref.27940358] Cytotoxicity: human embryonic fibroblasts (HEF) and human red blood cells (hRBC)(IC50 for arenicin-1 in the presence or absence of 10% FBS were of 35 and 8 M,HC50 indicating 50% hemolysis after 24 h incubation, equaled to 16M)." Anionic lipid vesicles 15527787##17935487 FEBS Lett. 2004 Nov 5;577(1-2):209-214.##Biochem J. 2008 Feb 15;410(1):113-122. "Ovchinnikova TV, Aleshina GM, Balandin SV, Krasnosdembskaya AD, Markelov ML, Frolova EI, Leonova YF, Tagaev AA, Krasnodembsky EG, Kokryakov VN.##Andr? J, Jakovkin I, Gr?tzinger J, Hecht O, Krasnosdembskaya AD, Goldmann T, Gutsmann T, Leippe M." "Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina.##Structure and mode of action of the antimicrobial peptide arenicin." DRAMP03176 SWLSKTAKKLENSAKKRISEGIAIAIQGGPR 31 "Cecropin-P1 (CP1; nematodes, animals)" "P14661, Q5H7N7" Belongs to the cecropin family ASCEC-1 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) "Antimicrobial, Antibacterial, Antifungal" Protein level Alpha helix Not found None "Function: Has antibacterial activity against several Gram-positive and Gram-negative bacteria. Is weakly active against yeasts. Acts by a nonpore mechanism. Induction: By bacterial infection." "P1-NH2 (amidated cecropin P1): [E. coli K-12/ D21 (MIC=0.3 ?M), E. coli 853/67/0149/K88 (MIC=0.9 ?M), E. coli Bd2221/75/08/K88 (MIC=0.6 ?M), E. coli Bd4462/84/0101/K99 (MIC=0.7 ?M), E. coli Bd4466/84/064/K99 (MIC=0.3 ?M), Salmonella typhimurium LT2 (MIC=0.9 ?M), A. calcoaceticus Ac1l (MIC=0.2 ?M), Proteus vulgaris Pvll (MIC=5.7 ?M), Pseudomonas aeruginosa OT97 (MIC=5.9 ?M), Bacillus megaterium Bmll (MIC=1.8 ?M), Streptococcus pyogenes (MIC=19 ?M)].##P1-OH (non-amidated cecropin P1): [E. coli K-12/ D21 (MIC=0.4 ?M), E. coli 853/67/0149/K88 (MIC=0.6 ?M), E. coli Bd2221/75/08/K88 (MIC=0.7 ?M), E. coli Bd4462/84/0101/K99 (MIC=0.8 ?M), E. coli Bd4466/84/064/K99 (MIC=0.6 ?M), Salmonella typhimurium LT2 (MIC=1.7 ?M), A. calcoaceticus Ac1l (MIC=0.5 ?M), Proteus vulgaris Pvll (MIC=12 ?M), Pseudomonas aeruginosa OT97 (MIC=13 ?M), Bacillus megaterium Bmll (MIC=5.3 ?M), Streptococcus pyogenes (MIC=44 ?M)]." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15850460##1396696 Biochem J. 2005 Aug 15;390(Pt 1):207-214.##Eur J Biochem. 1992 Oct 1;209(1):163-169. "llai A, Ueno S, Zhang H, Lee JM, Kato Y.##Sipos D, Andersson M, Ehrenberg A." "Cecropin P1 and novel nematode cecropins: a bacteria-inducible antimicrobial peptide family in the nematode Ascaris suum.##The structure of the mammalian antibacterial peptide cecropin P1 in solution, determined by proton-NMR." DRAMP03181 HVDKKVADKVLLLKQLRIMRLLTRL 25 "Spinigerin (Insects, animals)" P82357 Not found Not found Pseudacanthotermes spiniger (Termite) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found "1ZRW, 1ZRV resolved by NMR." Function: Active against Gram-positive bacteria and Gram-negative bacteria and fungi. "Gram-positive bacteria: Bacillus megaterium (MIC=0.8-1.5 ?M), Micrococcus luteus (MIC=0.8-1.5 ?M);##Gram-negative bacteria: Escherichia coli SBS363 (MIC=3-6 ?M), E. coli D22 (MIC=3-6 ?M), Klebsiella pneumoniae (MIC=50-100 ?M), Salmonella typhimurium (MIC=3-6 ?M), Pseudomonas aeruginosa (MIC=50-100 ?M).##Fungi: Trichoderma viride (MIC=1.5-3 ?M), Neurospora crassa (MIC=3-6 ?M), Fusarium culmorum (MIC=1.5-3 ?M), Nectria haematococca (MIC=0.4-0.8 ?M), Candida albicans (MIC=3-6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11053427##16170803 J Biol Chem. 2001 Feb 9;276(6):4085-4092.##Biopolymers. 2006 Feb 5;81(2):92-103. "Lamberty M, Zachary D, Lanot R, Bordereau C, Robert A, Hoffmann JA, Bulet P.##Landon C, Meudal H, Boulanger N, Bulet P, Vovelle F." "Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect.##Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation." DRAMP03186 SFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW 38 "Spheniscin-2 (Sphe-2; penguin avian beta-defensin 103b; birds ,animals)" P83430 Belongs to the beta-defensin family Not found Aptenodytes patagonicus (King penguin) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Beta strand (3 strands; 14 residues) "The overall fold of Sphe-2 includes a three-stranded antiparallel beta-sheet stabilized by three disulfide bridges with a pairing typical of beta-defensins. In addition, the N-terminal segment shows helical features on most structures.(Ref.2)" 1UT3 resolved by NMR. "Function: Has antimicrobial activity. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane Function: with its amphipathic structure. PTM: Contains three disulfide bond: 5-33; 12-27; 17-34. Preserving food in the bird somach for several weeks during egg incubation. The disulfide bond pattern is identical to canonical beta-defensins from mammals. The high potency is related to its high cationicity as well as a hydrophobic patch, which is not observed in mammalian defensins. " "[Ref.14525994]Gram-positive bacteria: Micrococcus luteus (MIC=1.5-3.0 ?M), Bacillus subtilis (MIC=0.8-1.5 ?M), Bacillus cereus ATCC 11778 (MIC=3-6 ?M), Bacillus megaterium (MIC=0.4-0.8 ?M), Staphylococcus aureus (MIC=1.5-3.0 ?M), Staphylococcus saprophyticus (MIC=1.5-3.0 ?M), Staphylococcus haemolyticus (MIC=1.5-3.0 ?M), Nocardia asteroides (MIC=0.8-1.5 ?M), Aerococcus viridans (MIC=0.4-0.8 ?M), Listeria monocytogenes (MIC=6-12 ?M);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=0.8-1.5 ?M), Escherichia coli 1106 (MIC=1.5-3.0 ?M), Salmonella typhimurium (MIC=6-12 ?M), Klebsiella pneumoniae (MIC=50-100 ?M), Pseudomonas aeruginosa ATCC 82118 (MIC=6-12 ?M), Vibrio metschnikovii NCTC 8483 (MIC=25-50 ?M), Vibrio anguillarum ATCC 19264 (MIC=25-50 ?M);##Fungi: Candida glabrata (MIC>100 ?M), Candida albicans IHEM 8060 (MIC=50-100 ?M), Candida tropicalis (MIC=1.5-3.0 ?M), Neurospora crassa (MIC=3-6 ?M),Aspergillus fumigatus (MIC=3-6 ?M)." It has hemolytic activity Cyclic Free Free Disulfide bonds between Cys5 and Cys33; Cys12 and Cys27; Cys17 and Cys34. L No cytotoxicity information found Not found 14525994##15123713 J Biol Chem. 2003 Dec 19;278(51):51053-51058.##J Biol Chem. 2004 Jul 16;279(29):30433-30439. "Thouzeau C, Le Maho Y, Froget G, Sabatier L, Le Bohec C, Hoffmann JA, Bulet P.##Landon C, Thouzeau C, Labb H, Bulet P, Vovelle F." "Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus.##Solution structure of spheniscin, a beta-defensin from the penguin stomach." DRAMP03187 QRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCR 36 "Beta defensin 1(BD-1; mammals, animals)" P83943 Belongs to the beta-defensin family DEFB1 Chinchilla lanigera (Long-tailed chinchilla) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Has antibacterial and antifungal activity. May have a role in maintaining sterility in the middle ear. Gram-negative bacterium: Moraxella catarrhalis (MIC=5 ?g/ml);##Gram-positive bacterium: Streptococcus pneumoniae (MIC=5 ?g/ml).##Fungi: Candida albicans (MIC=12.5-20 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14996845 J Biol Chem. 2004 May 7;279(19):20250-20256. "Harris RH, Wilk D, Bevins CL, Munson RS Jr, Bakaletz LO." Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway. DRAMP03190 RLGNFFRKAKKKIGRGLKKIGQKIKDFLGNLVPRTES 37 "PobRL-37 (cathelicidin; primates, mammals, animals)" No entry found Not found Not found Cercopithecidae "Antimicrobial, Antibacterial, Antifungal" Not found Not found Not found None Function: Has antibacterial activity. "In 20% TSB in SPB medium: Escherichia coli (MIC=0.5 ?M), Pseudomonas aeruginosa (MIC=0.5-1 ?M), Staphylococcus aureus (MIC=2 ?M), Enterococcus faecalis (MIC=2-4 ?M).##In 20% SAB in SPB: Candida albicans (MIC=8-16 ?M). In 5% TSB in SPB: Escherichia coli (MIC=0.5 ?M). In 5% SAB in SPB: Candida albicans (MIC=4-8 ?M).##In 20% TSB in PIL: Escherichia coli (MIC=1 ?M), Pseudomonas aeruginosa (MIC=1-2 ?M); Staphylococcus aureus (MIC=0.5 ?M), Enterococcus faecalis (MIC=1-2 ?M).##In 20% SAB in PIL: Candida albicans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16720578 J Biol Chem. 2006 Jul 21;281(29):19861-19871. "Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A." Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity. DRAMP03196 RCVCRRGVCRCVCTRGFC 18 "PhTD-1 (PhTD1; primates, mammals, animals)" "P86722, P86723" Not found Not found Papio hamadryas (Hamadryas baboon) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "In low salt conditions: Escherichia coli ML35p (MIC=1.5 ?M), Listeria monocytogenes EGD (MIC=1.6 ?M) and methicillin-resistant Staphylococcus aureus ATCC 33591 (MIC=2.5 ?M),.##Fungi: Candida albicans 820 (MIC=1.6 ?M);##At high physiological salt concentrations: Escherichia coli ML35p (MIC=2.0 ?M), Listeria monocytogenes EGD (MIC=1.7 ?M), Staphylococcus aureus ATCC 33591 (MIC=3.6 ?M), Candida albicans 820 (MIC=6.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys2 and Cys11; Cys4 and Cys9; Cys13 and Cys18. L No cytotoxicity information found Not found 20155756 Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604. "Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R." De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. DRAMP03197 RCVCTRGFCRCVCTRGFC 18 "PhTD-3 (PhTD3; primates, mammals, animals)" "P86722, P86723" Not found Not found Papio hamadryas (Hamadryas baboon) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "In low salt conditions: Escherichia coli ML35p (MIC=1.7 ?M), Listeria monocytogenes EGD (MIC=1.5 ?M), Staphylococcus aureus ATCC 33591 (MIC=1.7 ?M), Candida albicans 820 (MIC=1.4 ?M);##At high physiological salt concentrations: Escherichia coli ML35p (MIC=2.2 ?M), Listeria monocytogenes EGD (MIC=1.9 ?M), Staphylococcus aureus ATCC 33591 (MIC=4.5 ?M), Candida albicans 820 (MIC=7.4 ?M). " No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys2 and Cys11; Cys4 and Cys9; Cys13 and Cys18. L No cytotoxicity information found Not found 20155756 Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604. "Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R." De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. DRAMP03198 ACYCRIPACFAGERRYGTCFYLGRVWAFCC 30 "Alpha-defensin PhD-4 (primates, mammals, animals)" P86724 Belongs to the alpha-defensin family Not found Papio hamadryas (Hamadryas baboon) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial activity in low salt conditions, and the antimicrobial activity decreases significantly at high physiological salt concentrations. PTM: Contains three disulfide bonds (By similarity)." "In low salt conditions: Gram-negative bacterium: E. coli ML35p (MIC=2.4 ?M),;##Gram-positive bacteria: Listeria monocytogenes EGD (MIC=2.2 ?M), methicillin-resistant S. aureus ATCC 33591 (MIC=3.5 ?M).##Fungi: Candida albicans 820 (MIC=3.9 ?M).##At high physiological salt concentrations: E. coli ML35p (MIC=7.1 ?M), L. monocytogenes EGD (MIC=1.8 ?M), S. aureus ATCC 33591 (MIC>50 ?M), Candida albicans 820 (MIC>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20155756 Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604. "Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R." De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. DRAMP03215 ZCRRLCYKQRCVTYCRGR 18 "Gomesin (Gm; spiders, Arthropods, animals)" "P82358, Q86RA2" Not found Not found Acanthoscurria gomesiana (Tarantula spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor" Protein level Beta strand "Gm adopts a well-defined -hairpin-like struc ture, and the disulfide bonds have been reported to be important for the maintenance of this structure." 1KFP resolved by NMR. "[Ref.10942757]Function: Gomesin bound to the cell surface of cryptococci neoformans, which resulted in cell death associated with membrane permeabilization (FEMS Microbiol Lett. 2007 Sep;274(2):279-86). Also, this peptide triggers SH-SY5Y cell death through L-type channel calcium influx, MAPK/ERK, PKC and PI3K signaling and generation of reactive oxygen species (Soletti RC et al 2010 Chem Biol Interact 186: 135-43). Although represented by E, the N-terminal residue is a pyroglutamate. In hemocytes only, but not in all hemocytes observed.##[Ref.28741926]Function: Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, Antifungal activity agaist Candida albicans, Cryptococcus neoformans" "[Ref.10942757]Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 ?M), Bacillus cereus (MIC=6.25-12.5 ?M), Bacillus megaterium (MIC=0.2-0.4 ?M), Bacillus thuringiensis (MIC=1.6-3.15 ?M), Enterococcus faecalis (MIC=6.2-12.5 ?M), Listeria monocytogenes (MIC=0.8-1.6 ?M), Micrococcus luteus (MIC=0.4-0.8 ?M), Pediococcus acidolacrici (MIC=3.15-6.25 ?M), Staphylococcus aureus (MIC=1.6-3.15 ?M), S. epidermidis (MIC=0.8-1.6 ?M), S. haemolyticus (MIC=0.8-1.6 ?M), S. saprophyticus (MIC=0.8-1.6 ?M), Streptococcus pyogenes (MIC=1.6-3.15 ?M), Nocardia asteroides (MIC=1.6-3.15 ?M);##Gram-negative bacteria: Alcaligenes faecalis (MIC>100 ?M), Escherichia coli 1106 (MIC=0.8-1.6 ?M), E. coli D22 (MIC=0.4-0.8 ?M), E. coli D31 (MIC=0.8-1.6 ?M), E. coli SBS363 (MIC=0.4-0.8 ?M), Erwinia carolovora carolovora (MIC=3.15-6.25 ?M), Enterobacter cloacae beta 12 (MIC=3.15-6.25 ?M), Klebsiella pneumoniae (MIC=3.15-6.25 ?M), Pseudomonas aeruginosa (MIC=1.6-3.15 ?M), Salmonella typhimurium (MIC=0.8-1.6 ?M), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 ?M).##Fungi: Alternaria brassicola (MIC=0.4-0.8 ?M), Aspergillus fumigatus (MIC=1.6-3.15 ?M), Beauveria bassiana (MIC=12.5-25 ?M), Fusarium culmorum (MIC=0.4-0.8 ?M), F. oxysporum (MIC=0.4-0.8 ?M), Neurospora crassa (MIC=0.4-0.8 ?M), Nectria haematococca (MIC=0.2-0.4 ?M), Tricoderma viridae (MIC=0.4-0.8 ?M), Tricophvton mentagrophytes (MIC=0.8-1.6 ?M), C. albicans (MIC=0.15-0.3 ?M), C. glabrata (MIC=12.5-25 ?M), C. tropicalis (MIC=3.15-6.25 ?M), C. neoformans (MIC=0.8-1.6 ?M), Saccharomyces cerevisiae (MIC=1.6-3.15 ?M).##[Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=32 M);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 M), Klebsiella pneumoniae ATCC 700603 (MIC=32 M), Acinetobacter baumannii ATCC 19606 (MIC=4-8 M), Pseudomonas aeruginosa ATCC 27853 (MIC=8 M), Helicobacter pylori ATCC 43504 (MIC>80 M);##Fungi : Candida albicans ATCC 90028 (MIC=8-16 M), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 M)" "[Ref.28741926] It has 0% hemolysis at 6 M , 3% hemolysis at 10 M , 10% hemolysis at 5 M , 41.2-53.2% hemolysis at 64 M , 50% hemolysis at 100 M against human red blood cells" Cyclic pyroglutamic acid Amidation "Disulfide bond between Cys2 and Cys15,Cys6 and Cys11." L "[Ref.28741926] CC50 = 67.0 5.0 M against CRL-1739, CC50 = 3.7 0.2 M against MM96L, CC50 = 49.9 16.6M against HFF-1, CC50 =54.15.0 M against HeLa, CC50 = 3.8 0.3 M against K-562." Not found 10942757##28741926 J Biol Chem. 2000 Oct 27;275(43):33464-33470.##ACS Chem Biol.?2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459.? "Silva PI Jr, Daffre S, Bulet P.##Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval,Aurelie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan,Yen-Hua Huang, and David J. Craik" "Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.##Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties" DRAMP03226 SMWSGMWRRKLKKLRNALKKKLKGE 25 "M-zodatoxin-Lt1a (M-ZDTX-Lt1a; Latarcin-1, Ltc-1, Ltc1; spiders, Arthropods, animals)" Q1ELT9 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 16 residues) The Ltc1 molecule is found to form a straight uninterrupted amphiphilic helix comprising 8-23 residues. The hydrophobic surface of the Ltc1 helix is narrow-shaped and extends with no gradient along the axis. (Ref.2) 2PCO resolved by NMR. "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.5 ?M), Bacillus subtilis VKM B-501 (MIC=1.0 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 ?M), Escherichia coli MH1 (MIC=0.7?M), Pseudomonas aeruginosa PAO1 (MIC=4.1 ?M);##Fungi: Pichia pastoris GS115 (MIC=17 ?M), Saccharomyces cerevisiae Y190 (MIC>33 ?M)." [Ref.16735513]20% hemolytic activity at 80 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513##18293934 J Biol Chem. 2006 Jul 28;281(30):20983-20992.##Biochemistry. 2008 Mar 18;47(11):3525-3533. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.##Dubovskii PV, Volynsky PE, Polyansky AA, Karpunin DV, Chupin VV, Efremov RG, Arseniev AS." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.##Three-dimensional structure/hydrophobicity of latarcins specifies their mode of membrane activity." DRAMP03227 GLFGKLIKKFGRKAISYAVKKARGKH 26 "M-zodatoxin-Lt2a (M-ZDTX-Lt2a; Latarcin-2a, Ltc-2a, Ltc2a; spiders, Arthropods, animals)" Q1ELU1 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (2 helices; 18 residues) The molecule of Ltc2a is found to consist of two helical regions (residues 3-9 and 13-21) connected via a poorly ordered fragment. 2G9P resolved by NMR. "Function: Has hemolytic activity against Rabbit erythrocytes and has toxicity to ovarian insect Sf9 cells (EC50=20 ?M). Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. " "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 ?M), Bacillus subtilis VKM B-501 (MIC=0.4 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=1.0 ?M), Escherichia coli MH1 (MIC=0.7 ?M), Pseudomonas aeruginosa PAO1 (MIC=6.7 ?M);##Fungi: Pichia pastoris GS115 (MIC=6.7 ?M), Saccharomyces cerevisiae Y190 (MIC=54 ?M)." [Ref.16735513]20% hemolytic activity at 6 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513##16939228 J Biol Chem. 2006 Jul 28;281(30):20983-20992.##Biochemistry. 2006 Sep 5;45(35):10759-10767. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV.##Dubovskii PV, Volynsky PE, Polyansky AA, Chupin VV, Efremov RG, Arseniev AS." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.##Spatial structure and activity mechanism of a novel spider antimicrobial peptide." DRAMP03229 SWKSMAKKLKEYMEKLKQRA 20 "M-zodatoxin-Lt3a (M-ZDTX-Lt3a; Latarcin-3a, Ltc-3a; spiders, Arthropods, animals)" Q1ELU3 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 MIC=1.2 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=2.5 ?M), Escherichia coli MH1 (MIC=6.0 ?M), Pseudomonas aeruginosa PAO1 (MIC>40 ?M);##Fungi: Pichia pastoris GS115 (MIC=20 ?M), Saccharomyces cerevisiae Y190 (MIC=20 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03230 SWASMAKKLKEYMEKLKQRA 20 "M-zodatoxin-Lt3b (M-ZDTX-Lt3b; Latarcin-3b, Ltc-3b; spiders, Arthropods, animals)" Q1ELU2 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 ?M), Bacillus subtilis VKM B-501 (MIC=2.9 ?M);Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=23 ?M), Escherichia coli MH1 (MIC=28 ?M), Pseudomonas aeruginosa PAO1 (MIC>45 ?M);##Fungi: Pichia pastoris GS115 (MIC=23 ?M), Saccharomyces cerevisiae Y190 (MIC=23 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03231 GLKDKFKSMGEKLKQYIQTWKAKF 24 "M-zodatoxin-Lt4a (M-ZDTX-Lt4a; Latarcin-4a, Ltc-4a; spiders, Arthropods, animals)" Q1ELU5 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 (MIC=1.1 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=4.5 ?M), Escherichia coli MH1 (MIC=3.2 ?M), Pseudomonas aeruginosa PAO1 (MIC>35 ?M);##Fungi: Pichia pastoris GS115 (MIC=36 ?M), Saccharomyces cerevisiae Y190 (MIC=18 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03232 SLKDKVKSMGEKLKQYIQTWKAKF 24 "M-zodatoxin-Lt4b (M-ZDTX-Lt4b; Latarcin-4b, Ltc-4b; spiders, Arthropods, animals)" Q1ELU4 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has hemolytic activity against Rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 ?M), Bacillus subtilis VKM B-501 (MIC=1.1 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=4.4 ?M), Escherichia coli MH1 (MIC=4.4 ?M), Pseudomonas aeruginosa PAO1 (MIC>35 ?M);##Fungi: Pichia pastoris GS115 (MIC>35 ?M), Saccharomyces cerevisiae Y190 (MIC=35 ?M)." [Ref.16735513]20% hemolytic activity at >120 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-209892. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV." "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03233 GFFGKMKEYFKKFGASFKRRFANLKKRL 28 "M-zodatoxin-Lt5a (M-ZDTX-Lt5a; Latarcin-5, Ltc-5; spiders, Arthropods, animals)" Q1ELU9 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Has antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria and and yeasts. Also has hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. Tissue specificity: Expressed by the venom gland. PTM: Leucine amide at L28." "[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=1.1 ?M), Bacillus subtilis VKM B-501 (MIC=0.6 ?M);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=0.6 ?M), Escherichia coli MH1 (MIC=0.6 ?M), Pseudomonas aeruginosa PAO1 (MIC=18 ?M);##Fungi: Pichia pastoris GS115 (MIC>37 ?M), Saccharomyces cerevisiae Y190 (MIC>37 ?M)." [Ref.16735513]20% hemolytic activity at 40 M against rabbit erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-20992. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV. " "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03253 GKLQAFLAKMKEIAAQTL 18 "M-lycotoxin-Ls3a (M-LCTX-Ls3a; Lycocitin-1; spiders, Arthropods, animals)" P0C2U6 Not found Not found Lycosa singoriensis (Wolf spider) (Aranea singoriensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits growth of Gram-positive and Gram-negative bacteria and fungi. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis ATCC6633 (MIC=1.6-3.2 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=3.2-6.4 ?M), Pseudomonas aeruginosa.##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14991689 J Mass Spectrom. 2004 Feb;39(2):193-201. "Budnik BA, Olsen JV, Egorov TA, Anisimova VE, Galkina TG, Musolyamov AK, Grishin EV, Zubarev RA." De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis. DRAMP03254 GRLQAFLAKMKEIAAQTL 18 "M-lycotoxin-Ls3b (M-LCTX-Ls3b; Lycocitin-2; spiders, Arthropods, animals)" P0C2U7 Not found Not found Lycosa singoriensis (Wolf spider) (Aranea singoriensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Inhibits growth of Gram-positive and Gram-negative bacteria and fungi. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation." "Gram-positive bacteria: Staphylococcus aureus 209P, Bacillus subtilis ATCC 6633 (MIC=1.57-3.14 ?M);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=3.14-6.29 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=5.02-10.05 ?M).##Fungi: Candida albicans. " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14991689 J Mass Spectrom. 2004 Feb;39(2):193-201. "Budnik BA, Olsen JV, Egorov TA, Anisimova VE, Galkina TG, Musolyamov AK, Grishin EV, Zubarev RA." De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis. DRAMP03278 IWLTALKFLGKHAAKHLAKQQLSKL 25 "M-lycotoxin-Hc1a (M-LCTX-Hc1a; Lycotoxin I; spiders, Arthropods, animals)" P61507 Not found Not found Hogna carolinensis (Carolina wolf spider) (Lycosa carolinensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. Is lethal to lepidopteran larvae. May Function: both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion." "Gram-positive bacteria: Bacillus thuringiensis subsp. Israelensis (MIC<5.0 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC=10-20 ?M), Escherichia coli DH5 (MIC=80-150 ?M).##Fungi: Candida glabrata ATCC 2001 (MIC=100-150 ?M), Candida albicans clinical isolate (MIC=100-200 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 9442044##18098329 J Biol Chem. 1998 Jan 23;273(4):2059-2066.##J Pept Sci. 2008 Apr;14(4):528-534. "Yan L, Adams ME.##Ad?o R, Seixas R, Gomes P, Pessoa JC, Bastos M." "Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.##Membrane structure and interactions of a short Lycotoxin I analogue." DRAMP03279 KIKWFKTMKSIAKFIAKEQMKKHLGGE 27 "M-lycotoxin-Hc2a (M-LCTX-Hc2a; Lycotoxin-2; Lycotoxin II; spiders, Arthropods, animals)" P61508 Not found Not found Hogna carolinensis (Carolina wolf spider) (Lycosa carolinensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. May Function: both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion." "Gram-positive bacteria: Bacillus thuringiensis subsp. Israelensis (MIC=10-60 ?M);##Gram-negative bacteria: Escherichia coli D31 (MIC<10 ?M), Escherichia coli DH5 (MIC<40 ?M).##Fungi: Candida glabrata ATCC 2001 (MIC=100-150 ?M)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 9442044##18098329 J Biol Chem. 1998 Jan 23;273(4):2059-2066.##J Pept Sci. 2008 Apr;14(4):528-534. "Yan L, Adams ME.##Ad?o R, Seixas R, Gomes P, Pessoa JC, Bastos M." "Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.##Membrane structure and interactions of a short Lycotoxin I analogue." DRAMP03280 ATYDGKCYKKDNICKYKAQSGKTAICKCYVKVCPRDGAKCEFDSYKGKCYC 51 AcAMP (A. clavatus antimicrobial peptide) No entry found Not found Not found Aspergillus clavatus ES1 "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Not found Not found Not found None "This basic, Cys-rich antifungal peptide is also active against bacteria. AcAMP was sensitive to proteolytic enzymes, stable between pH 5.0 and 10.0, and heat resistant (15 min at 100 degrees C). " "Gram-positive bacteria: Staphylococcus aureus (MIC=20 ?g/ml), Bacillus cereus (MIC=10 ?g/ml), Micrococcus luteus (MIC=10 ?g/ml), Enterococcus faecalis (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=30 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml).##Fungi: Aspergillus niger, Fusarium solani, Fusarium oxysporum." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20440534 J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-813. "Hajji M, Jellouli K, Hmidet N, Balti R, Sellami-Kamoun A, Nasri M." A highly thermostable antimicrobial peptide from Aspergillus clavatus ES1: biochemical and molecular characterization. DRAMP03286 APGNKAECEREKGYCGFLKCSFPFVVSGKCSRFFFCCKNIW 41 "Ostricacin-2 (Beta-defensin 1; Birds, animals)" P85114 Belongs to the beta-defensin family Not found Struthio camelus (Ostrich) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None PTM: Contains three disulfide bonds 8-36; 15-30; 20-37. Gram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=1.25 ?g/ml);##Gram-negative bacterium: Escherichia coli O157:H7 (MIC=0.96 ?g/ml);##Yeast: Candida albicans 3153A (MIC=6.2 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys8 and Cys36,Cys15 and Cys30,Cys20 and Cys37." L No cytotoxicity information found Not found 16459058 Int J Antimicrob Agents. 2006 Mar;27(3):229-235. "Sugiarto H, Yu PL." Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins. DRAMP03321 VISIIPV 7 Colutellin-A P86168 Not found Not found Colletotrichum dematium (Anthracnose fungus) "Antimicrobial, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Fungi: Sclerotinia sclerotiorum (MIC=32.4 ?g/ml after 288 hours), Botrytis cinerea (MIC=10.8 ?g/ml after 288 hours),Fusarium solani, Aspergillus fumigatus, Geotrichum candidum." No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal None L [Ref.18599825] It has less cytotoxicity against human PBMCs. Not found 18599825 Microbiology. 2008 Jul;154(Pt 7):1973-1979. "Ren Y, Strobel GA, Graff JC, Jutila M, Park SG, Gosh S, Teplow D, Condron M, Pang E, Hess WM, Moore E." "Colutellin A, an immunosuppressive peptide from Colletotrichum dematium." DRAMP03405 GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE 33 "mCRAMP-1 (mouse cathelin-related antimicrobial peptide 1; cathelicidin; Rodents, mammals, animals" "P51437, Q0VB78" Not found Camp Mus musculus (Mouse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix (CD) The spectra of 10-25 ?m synthetic CRAMP-1 in buffer suggest that the peptide is in a random coil configuration and that it will assume a helical structure in the presence of 15C45% (v/v) trifluoroethanol. None "Function: Acts as a potent antimicrobial peptide. Tissue specificity: Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=2 ?M), Escherichia coli D21 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan I (MIC=32 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus aureus (MRSA) (MIC=64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=16 ?M), Streptococcus faecalis ATCC 29212 (MIC=16 ?M), Bacillus megaterium Bm11 (MIC=4 ?M).##Fungi: Candida albicans (MIC>64 ?M), Cryptococcus neoformans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9148921##8706928 J Biol Chem. 1997 May 16;272(20):13088-13093.##FEBS Lett. 1996 Aug 5;391(1-2):5-8. "Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R.##Popsueva AE, Zinovjeva MV, Visser JW, Zijlmans JM, Fibbe WE, Belyavsky AV." "Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse.##A novel murine cathelin-like protein expressed in bone marrow." DRAMP03406 ISRLAGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE 38 "mCRAMP-2 (mouse cathelin-related antimicrobial peptide 2; cathelicidin; Rodents, mammals, animals" "P51437, Q0VB78" Not found Camp Mus musculus (Mouse) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix (CD) The CD spectra of CRAMP-2 (not shown) were similar to CRAMP-1. None "Function: Acts as a potent antimicrobial peptide. Tissue specificity: Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver." "Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 ?M), Escherichia coli ML35 (MIC=2 ?M), Escherichia coli D21 (MIC=8 ?M), Pseudomonas aeruginosa ATCC 27853 (MIC=4 ?M), Serratia marcescens ATCC 8100 (MIC=4 ?M);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 ?M), Staphylococcus aureus Cowan I (MIC=32 ?M), Staphylococcus aureus (MRSA) (MIC>64 ?M), Staphylococcus aureus (MRSA) (MIC=64 ?M), Staphylococcus epidermidis ATCC 12228 (MIC=16 ?M), Streptococcus faecalis ATCC 29212 (MIC=32 ?M), Bacillus megaterium Bm11 (MIC=4 ?M).##Fungi: Candida albicans (MIC>64 ?M), Cryptococcus neoformans (MIC=16 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9148921##8706928 J Biol Chem. 1997 May 16;272(20):13088-13093.##FEBS Lett. 1996 Aug 5;391(1-2):5-8. "Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R.##Popsueva AE, Zinovjeva MV, Visser JW, Zijlmans JM, Fibbe WE, Belyavsky AV." "Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse.##A novel murine cathelin-like protein expressed in bone marrow." DRAMP03419 VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR 32 "Neutrophil antibiotic peptide NP-1 (RatNP-1; Rodents, mammals, animals)" Q62716 Belongs to the alpha-defensin family Not found Rattus norvegicus (Rat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Comment: Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus." "Gram-positive bacterium: Staphylococcus aureus 502A [18 h] (MIC<100 cfu/ml);##Gram-negative bacterium: Escherichia coli ML-35 [18 h] (MIC<100 cfu/ml).##Fungi: Candida albicans 820 [18 h] (MIC<100 cfu/ml), Cryptococcus neoformans A-383 [18 h] (MIC=1.7 x 102 cfu/ml). " No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30." L No cytotoxicity information found Not found 2543629##7594610 Infect. Immun. 1989;57:2021-2027.##J. Immunol. 1995;155:4476-4484. "Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Selsted M.E, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E." Purification and antimicrobial properties of three defensins from rat neutrophils.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. DRAMP03422 ACYCRIGACVSGERLTGACGLNGRIYRLCCR 31 "Neutrophil antibiotic peptide NP-4 (RatNP-4; Rodents, mammals, animals)" Q62714 Belongs to the alpha-defensin family Np4 Rattus norvegicus (Rat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Bridge Not found None "Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus." "Gram-positive bacterium: Staphylococcus aureus 502A (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35, Acinetobacter calcoaceticus (MIC=50 ?g/ml).Fungi: Cryptococcus neoformans (MIC=10 ?g/ml), Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29." L No cytotoxicity information found Not found 2543629##7594610 Infect. Immun. 1989;57:2021-2027.##J. Immunol. 1995;155:4476-4484. "Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Selsted M.E, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E." Purification and antimicrobial properties of three defensins from rat neutrophils.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. DRAMP03464 GLLNGLALRLGKRALKKIIKRLCR 24 "Cryptonin (Insects, animals)" P85028 Not found Not found Cryptotympana dubia (Korean horse cicada) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None Function: Has very low hemolytic activity on rat erythrocytes. "[Ref.18000874]Gram-positive bacteria: Bacillus subtilis KCTC 3086 (MIC=3.12 ?g/ml), Staphylococcus aureus KCTC 1928 (MIC=25 ?g/ml), Micrococcus luteus KCTC 3063 (MIC=1.56 ?g/ml), Staphylococcus aureus (MRSA) (MIC=25 ?g/ml), VRE (MIC=25 ?g/ml);##Gram-negative bacteria: Escherichia coli K12-594 (MIC=3.12 ?g/ml);##Fungi: Candida albicans KCTC 7965 (MIC=50 ?g/ml), Candida tropicalis KCTC 1925 (MIC=3.12 ?g/ml)." [Ref.18000874]<5% hemolytic activity at 25-200 ?g/ml against rat erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18000874 Arch Insect Biochem Physiol. 2007 Dec;66(4):204-213. "Leem JY, Park DS, Suh EY, Hur JH, Oh HW, Park HY." "Isolation and functional analysis of a 24-residue linear alpha-helical antimicrobial peptide from Korean blackish cicada, Cryptotympana dubia (Homoptera)." DRAMP03465 NEYHGFVDKANNENKRKKQQGRDDFVVKPNNFANRRRKDDYNENYYDDVDAADVV 55 "Cicadin (Insects, animals)" P83282 Not found Not found Cicada flammata "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None "Function: Possesses antifungal activity against B.cinerea, M.arachidicola, F.oxysporum, R.solani and C.comatus. Suppresses the activity of HIV-1 reverse transcriptase and stimulates the proliferation of murine splenocytes." "Fungi: Botrytis cinerea (MIC=100 nM), Mycosphaerella arachidicola (MIC=70 nM), Fusarium oxysporum (MIC=180 nM), Physalospora piricola (MIC=60 nM), Rhizoctonia solani, Coprinus comatus, HIV-1 reverse transcriptase." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11814612 Peptides. 2002;23:7-11. "Wang H, Ng TB." "Isolation of cicadin, a novel and potent antifungal peptide from dried juvenile cicadas." DRAMP03471 GFGCPGNQLKCNNHCKSISCRAGYCDAATLWLRCTCTDCNGKK 43 "Recombinant Crassostrea Gigas Defensin (Cg-Def; molluscs, animals)" Q4GWV4 Not found def Crassostrea gigas (Pacific oyster) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Combine helix and strand structure Not found 2B68 resolved by NMR. Function: Has antibacterial activity (By similarity). "Gram-positive bacteria: Micrococcus lysodeikticus (MIC=0.005-0.01 ?M), Staphylococcus aureus (MIC=1.25-2.5 ?M), Microbacterium maritypicum (MIC=0.5-1 ?M), Bacillus megaterium (MIC>20 ?M);##Gram-negative bacteria: Escherichia coli 363 (MIC=35-20 ?M), Vibrio alginolyticus (MIC>20 ?M), Salmonella typhimurium (MIC>20 ?M).##Fungi: Fusarium oxysporum (MIC=9-4.5 ?M), Botrytis cinerea (MIC>20 ?M), Penicillium crustosum (MIC>20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid II 16246846 J Biol Chem. 2006 Jan 6;281(1):313-323. "Gueguen Y, Herpin A, Aumelas A, Garnier J, Fievet J, Escoubas JM, Bulet P, Gonzalez M, Lelong C, Favrel P, Bachre E." "Characterization of a defensin from the oyster Crassostrea gigas. Recombinant production, folding, solution structure, antimicrobial activities, and gene expression." DRAMP03472 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 74 cgUbiquitin No entry found Not found Not found Crassostrea gigas (Pacific oyster) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Combine helix and strand structure "According to the homology modeling, this peptide is composed of three secondary structural motifs including three -helices and four -strands separated by 7 loops regions." None "Function: cgUbiquitin shows broad potent antimicrobial activity against Gram-positive and -negative bacteria, without hemolytic activity." "[Ref.22858580]Gram-positive bacteria: B. subtilis KCTC1021 (MIC=0.4 ?M), S. aureus RM4220 (MIC=4.7 ?M), S. iniae FP5229 (MIC=0.9 ?M);##Gram-negative bacteria: E. coli D31 (MIC=0.2 ?M), E. coli ML35p (MIC=1.4 ?M), P. aeruginosa KCTC2004 (MIC=0.6 ?M), S. flexneri KCTC2517 (MIC=0.7 ?M), S. sonnei KCTC2009 (MIC=1.2 ?M), A. hydrophila KCTC2358 (MIC=0.7 ?M), V. parahemolyticus KCCM41664 (MIC=1.1 ?M);##Yeast: C. albicans KCTC7965 (MIC=9.4 ?M)." [Ref.22858580]Non-hemolytic against human red blood cells up to 100 g/mL Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22858580 Mol Immunol. 2013 Jan;53(1-2):88-98. "Seo JK, Lee MJ, Go HJ, Kim GD, Jeong HD, Nam BH, Park NG." "Purification and antimicrobial function of ubiquitin isolated from the gill of Pacific oyster, Crassostrea gigas." DRAMP03474 VRPYLVAF 8 Pleurostatin (Fungus) P84866 Not found Not found Pleurotus ostreatus (Oyster mushroom) "Antimicrobial, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database 20% growth inhibition Fusarium oxysporum (MIC=15.6 ?M).##45% growth inhibition Mycosphaerella arachidicola (MIC=15.6 ?M).##63% growth inhibition Physalospora piricola (MIC=15.6 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15941607 Peptides. 2005 Nov;26(11):2098-103. Epub 2005 Jun 6. "Chu K.T, Xia L, Ng T.B. " "Pleurostrin, an antifungal peptide from the oyster mushroom" DRAMP03493 DKLIGSCVWGAVNYTSDCNGECKRRGYKGGHCGSFANVNCWCET 44 "Defensin heliomicin (Insects, animals)" P81544 Not found Not found Heliothis virescens (Tobacco budworm moth) "Antimicrobial, Antifungal" Protein level Combine helix and strand structure Not found "1I2U,1I2V resolved by NMR. " "Similar to plant defensin RsAFP2 (also in structure), it interacts with glucosylceramide isolated from the membranes of yeast and soybean but not humans (J Biol Chem 2004; 279: 3900-3905). Transgenic plants: expression of this peptide in tobacco improves resistance to pathogens (Montesinos E 2007 FEMS Microbiol Lett 270, 1-11)." "Fungi: Neurospora crassa (MIC=0.1-0.2 ?M), Fusarium culmorum (MIC=0.2-0.4 ?M), Fusarium oxysporum (MIC=1.5-3 ?M), Nectria haematococca (MIC=0.4-0.8 ?M), Aspergillus fumigatus (MIC=6-12 ?M), Trichoderma viride (MIC=1.5-3 ?M), Candida albicans (MIC=2.5-5 ?M), Cryptococcus neoformans (MIC=2.5-5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10092609##11580275 J Biol Chem. 1999 Apr 2;274(14):9320-9326.##Biochemistry. 2001 Oct 9;40(40):11995-2003. "Lamberty M, Ades S, Uttenweiler-Joseph S, Brookhart G, Bushey D, Hoffmann JA, Bulet P.##Lamberty M, Caille A, Landon C, Tassin-Moindrot S, Hetru C, Bulet P, Vovelle F." Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity.##Solution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activities. DRAMP03507 KWKIFKKIEKVGRNIRNGIIKAGPAVAVLGEAKAL 35 "Cecropin-B (Insects, animals)" P01509 Belongs to the cecropin family Not found Antheraea pernyi (Chinese oak silkmoth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=0.36 ?M), Escherichia coli D31 (MIC=0.30 ?M), Serratia marsescens (MIC=2.6 ?M), Serratia marsescens Strain 122 (MIC=12 ?M), Pseudomonas aeruginosa OT97 (MIC=2.9 ?M), Xenorhabdus nematophilus Xn21 (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis Bsll (MIC=17 ?M), Bacillus megaterium Bmll (MIC=0.64 ?M), Bacillus thuringiensis Btll (MIC>88 ?M), Streptococcus fecalis Ds16 (MIC>88 ?M), Streptococcus fecalis AD-4 (MIC>88 ?M), Micrococcus luteus MI11 (MIC=0.29 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 6754375##2962676 Eur J Biochem. 1982 Sep;127(1):219-224.##Biomed Environ Mass Spectrom. 1987 Nov;14(11):669-673. "Qu Z, Steiner H, Engstr?m A, Bennich H, Boman HG.##Craig AG, Engstr?m A, Bennich H, Kamensky I." "Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi.##Plasma desorption mass spectrometry coupled with conventional peptide sequencing techniques." DRAMP03513 KVNVNAIKKGGKAIGKGFKVISAASTAHDVYEHIKNRRH 39 "G. mellonella moricin-like peptide A (Gm-mlpA; Insects, animals; Predicted)" A5JSU5 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=10 ?M).##Fungi: Fusarium graminearum mycelia (MIC=70 ?M), F;##Graminearum spores (MIC=0.7 ?M), Fusarium oxysporum mycelia (MIC=7 ?M), F. oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=7 ?M), Leptosphaeria maculans spores (MIC=7 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03514 GKIPVKAIKKGGQIIGKALRGINIASTAHDIISQFKPKKKKNH 43 "G. mellonella moricin-like peptide B (Gm-mlpB; Insects, animals; Predicted)" A5JSU6 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), F;##Graminearum mycelia (MIC=280 ?M), Fusarium oxysporum spores (MIC=100 ?M), F. oxysporum mycelia (MIC=280 ?M), Leptosphaeria maculans spores (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03515 KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRH 38 "Moricin-like peptide C1 (Gm-mlpC1; Insects, animals; Predicted)" A5JSU7 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=1 ?M), Fusarium oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=100 ?M), Leptosphaeria maculans spores (MIC=6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03516 KVPIGAIKKGGKIIKKGLGVLGAAGTAHEVYNHVRNRQ 38 "Moricin-like peptide C2 (Gm-mlpC2; Insects, animals; Predicted)" A5JSU8 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=10 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=1 ?M), Fusarium oxysporum spores (MIC=10 ?M), Ascochyta rabiei spores (MIC=100 ?M), Leptosphaeria maculans spores (MIC=8 ?M), Fusarium graminearum mycelia (MIC=8 ?M), Fusarium oxysporum mycelia (MIC=8 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03517 KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRQ 38 "Moricin-like peptide C3 (Gm-mlpC3; Insects, animals; Predicted)" A5JSU9 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=100 ?M);##Gram-positive bacterium: Micrococcus luteus (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), Fusarium oxysporum spores (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03518 KVPVGAIKKGGKAIKTGLGVVGAAGTAHEVYSHIRNRH 38 "Moricin-like peptide C4/C5 (Gm-mlpC4/C5; Insects, animals; Predicted)" A5JSV1 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database Gram-negative bacterium: Escherichia coli (MIC=100 ?M).##Fungi: Fusarium graminearum spores (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03519 KGIGSALKKGGKIIKGGLGALGAIGTGQQVYEHVQNRQ 38 "Moricin-like peptide D (Gm-mlpD; Insects, animals; Predicted)" A5JSV2 Not found mor Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Predicted Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=10 ?M).##Fungi: Fusarium graminearum spores (MIC=10 ?M), Fusarium oxysporum spores (MIC=100 ?M), Ascochyta rabiei spores(MIC=100 ?M), Leptosphaeria maculans spores (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18207081 Insect Biochem Mol Biol. 2008;38:201-212. "Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD." The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. DRAMP03520 ENFFKEIERAGQRIRDAIISAAPAVETLAQAQKIIKGGD 39 "Cecropin-D-like peptide (Insects, animals)" P85210 Not found Not found Galleria mellonella (greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus, Listeria monocytogenes, Sarcina Lutea, Escherichia coli D31(MIC=6.9-8.6 ?M), Aspergillus niger." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11995991##17194500 Acta Biochim Pol. 2001;48(4):1191-1195.##Peptides. 2007 Mar;28(3):533-546. "Mak P, Chmiel D, Gacek GJ.##Cytrynska M, Mak P, Zdybicka-Barabas A, Suder P, Jakubowicz T." Antibacterial peptides of the moth Galleria mellonella.##Purification and characterization of eight peptides from Galleria mellonella immune hemolymph. DRAMP03521 DIQIPGIKKPTHRDIIIPNWNPNVRTQPWQRFGGNKS 37 "Proline-rich antimicrobial peptide 1 (Insects, animals)" P85214 Not found Not found Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Micrococcus luteus(MIC=55.0 ?M).##Fungi: Pichia pastoris (MIC=16.5 ?M), Zygosaccharomyces marxianus (MIC=16.5 ?M), Schizosaccharomyces pombe (MIC=11 ?M), candida wickerhamii (MIC=16.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11995991##17194500 Acta Biochim Pol. 2001;48(4):1191-1195.##Peptides. 2007 Mar;28(3):533-546. "Mak P, Chmiel D, Gacek GJ.##Cytrynska M, Mak P, Zdybicka-Barabas A, Suder P, Jakubowicz T." Antibacterial peptides of the moth Galleria mellonella.##Purification and characterization of eight peptides from Galleria mellonella immune hemolymph. DRAMP03523 ETESTPDYLKNIQQQLEEYTKNFNTQVQNAFDSDKIKSEVNNFIESLGKILNTEKKEAPK 60 "Anionic antimicrobial peptide 2 (Insects, animals)" P85216 Not found Not found Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus(MIC=43.3-86.6 ?M), Listeria monocytogenes (MIC=86.6 ?M), Sarcina Lutea (MIC=86.6 ?M).##Fungi: Pichia pastoris (MIC=43.3-86.6 ?M), P. stipitis (MIC=43.3-86.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17194500 Peptides. 2007;28:533-546. "Cytrynska M, Mak P, Zdybicka-Barabas A, Suder P, Jakubowicz T." Purification and characterization of eight peptides from Galleria mellonella immune hemolymph DRAMP03524 EADEPLWLYKGDNIERAPTTADHPILPSIIDDVKLDPNRRYA 42 "Lebocin-like anionic peptide 1 (Insects, animals)" P85211 Not found Not found Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus(MIC=22.7 ?M), Listeria monocytogenes (MIC=90.9 ?M).##Fungi: Aspergillus niger (MIC=90.9 ?M), Trichoderma harzianum (MIC=90.9 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17194500 Peptides. 2007;28:533-546. "Cytrynska M, Mak P, Zdybicka-Barabas A, Suder P, Jakubowicz T." Purification and characterization of eight peptides from Galleria mellonella immune hemolymph. DRAMP03527 DKLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFWNVNCWCEE 44 "Gm defensin-like peptide (Insects, animals)" P85215 Not found Not found Galleria mellonella (Greater wax moth) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Bridge Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Sarcina Lutea (MIC=1.9 ?M).##Fungi: Aspergillus niger (MIC=2.9 ?M), Candida albicans (MIC=2.9 ?M), C. fructus (MIC=2.9 ?M), Candida wickerhamii (MIC=2.9 ?M), Pichia pastoris (MIC=2.9 ?M), P. stiptis (MIC=2.9 ?M), Pachysolen tannophilus (MIC=2.9 ?M), Trichoderma harzianum (MIC=2.9 ?M), Zygosaccharomyces marxianus (MIC=2.9 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Has three disulfide bonds L No cytotoxicity information found Not found 17194500 Peptides. 2007 Mar;28(3):533-546. "Cytry??ska M, Mak P, Zdybicka-Barabas A, Suder P, Jakubowicz T." Purification and characterization of eight peptides from Galleria mellonella immune hemolymph. DRAMP03528 DTLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFLNVNCWCE 43 "Defensin (Galiomicin; Insects, animals)" "P85213, Q6QR79" Not found Not found Galleria mellonella (Greater wax moth) "Antimicrobial, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Fungi: Aspergillus niger (MIC=2.1 ?M), Candida albicans (MIC=8.5 ?M), C. fructus (MIC=8.5 ?M), Fusarium oxysporum (MIC=16.9 ?M), Pichia pastoris (MIC=16.9 ?M), Pachysolen tannophilus (MIC=8.5 ?M), Trichoderma harzianum (MIC=4.2 ?M), Zygosaccharomyces Marxianus (MIC=8.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17194500##14728668 Peptides. 2007 Mar;28(3):533-546.##Insect Mol Biol 2004; 13: 65-72. "Cytrynska M, Mak P, Zdybicka-Barabas A, Suder P, Jakubowicz T.##Lee Y.S, Yun E.K, Jang W.S, Kim I, Lee J.H, Park S.Y, Ryu K.S, Seo S.J, Kim C.H, Lee I.H." "Purification and characterization of eight peptides from Galleria mellonella immune hemolymph.##Purification, cDNA cloning and expression of an insect defensin from the great wax moth, Galleria mellonella." DRAMP03539 EWEPVQNGGSSYYMVPRIWA 20 Antifungal protein (Psc-AFP) No entry found Not found Not found Cullen corylifolium "Antimicrobial, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Fungi: Alternaria brassicae (MIC=10 ?M), Aspergillus niger (MIC=10 ?M), Fusarium oxysporum (MIC=10 ?M), Rhizoctonia cerealis (MIC=10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16530884 Peptides. 27:1726-1731(2006) "Yang X, Li J, Wang X, Fang W, Bidochka M.J, She R, Xiao Y, Pei Y." "Psc-AFP, an antifungal protein with trypsin inhibitor activity from Psoralea corylifolia seeds" DRAMP03540 CLAGRLDKQCTCRRSQPSRRSGHEVGRPSPHCGPSRQCGCHMD 43 "Human drosomycin-like defensin (DLD; Human, mammals, animals)" No entry found Not found Not found Homo sapiens (Human) "Antimicrobial, Antifungal" Not found Bridge Not found None "Function: This is the first indication of an endogenous human peptide with specific antifungal activity, which is probably central in the defense against infections with molds." "Filamentous fungi: Aspergillus fumigatus (MIC=6.25 ?M), A. nidulans (MIC=6.25 ?M), A. ustus (MIC=12.5 ?M), Fusarium solani (MIC=25 ?M), F. oxysporum (MIC=6.25 ?M), R. oryzae (MIC=6.25 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free Has three disulfide bonds L No cytotoxicity information found Not found 18212107 Antimicrob Agents Chemother 2008; 52: 1407-1412. Simon A et al Netea MG. "Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity." DRAMP03562 FLAKAVAKAAAKALAKAL 18 "P1 (Human, mammals, animals)" No entry found Not found Not found Homo sapiens (Human) "Antimicrobial, Antifungal" Not found Not found Not found None Function: Presentes antifungal activity against Candida albicans. Yeast: Candida albicans (MIC=82 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22884922 Peptides. 2012 Oct;37(2):301-308. "Amaral AC, Silva ON, Mundim NC, de Carvalho MJ, Migliolo L, Leite JR, Prates MV, Bocca AL, Franco OL, Felipe MS." Predicting antimicrobial peptides from eukaryotic genomes: In silico strategies to develop antibiotics. DRAMP03563 KAGLAFPVGRVHRLLRK 17 "P2 (Human, mammals, animals)" No entry found Not found Not found Homo sapiens (Human) "Antimicrobial, Antifungal" Not found Not found Not found None Function: Presentes antifungal activity against Candida albicans. Yeast: Candida albicans (MIC=133 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22884922 Peptides. 2012 Oct;37(2):301-308. "Amaral AC, Silva ON, Mundim NC, de Carvalho MJ, Migliolo L, Leite JR, Prates MV, Bocca AL, Franco OL, Felipe MS." Predicting antimicrobial peptides from eukaryotic genomes: In silico strategies to develop antibiotics. DRAMP03567 KRIVQRIKDFLRNLVPRTES 20 KR-20 (Derived from LL-37) No entry found Not found Not found Homo sapiens (Human sweat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Staphylococcus aureus mprF (MIC=16 ?M), Staphylococcus aureus ATCC 25923 (MIC>64 ?M), Staphylococcus aureus (GAS) (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC>64 ?M).##Yeast: Candida albicans ATCC 14053 (MIC=10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 14978112 J Immunol 2004; 172: 3070-3077. "Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL." Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. DRAMP03568 RKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 31 RK-31 (Derived from LL-37) No entry found Not found Not found Homo sapiens (Human sweat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Function: Has hemolytic activity against human erythrocytes . "[Ref.14978112]Gram-positive bacteria: Staphylococcus aureus mprF (MIC=8 ?M), Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Group A Staphylococcus aureus (GAS) (MIC=8 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC=8 ?M);##Yeast: Candida albicans ATCC 14053 (MIC=4 ?M)." [Ref.14978112]6% hemolytic activity at 44 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 14978112 J Immunol 2004; 172: 3070-3077. "Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL." Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. DRAMP03569 KSKEKIGKEFKRIVQRIKDFLRNLVPRTES 30 KS-30 (Derived from LL-37) No entry found Not found Not found Homo sapiens (Human sweat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix Not found None Function:Has hemolytic activity against human erythrocytes. "[Ref.14978112]Gram-positive bacteria: Staphylococcus aureus mprF (MIC=8 ?M), Staphylococcus aureus ATCC 25923 (MIC=16 ?M), Group A Staphylococcus aureus (GAS) (MIC=4 ?M);##Gram-negative bacterium: Escherichia coli O29 (MIC=8 ?M);##Yeast: Candida albicans ATCC 14053 (MIC=2 ?M)" [Ref.14978112]23% hemolytic activity at 88 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 14978112 J Immunol 2004; 172: 3070-3077. "Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL." Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. DRAMP03570 LLGDFFRKSKEKIGKEFKRIVQR 23 LL-23 (Derived from LL-37) "P49913, Q71SN9" Not found Not found Homo sapiens (Human sweat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix (1 helices; 19 residues) "The Ser9 site splits the hydrophobic surface of the amphipathic helix into two domains, which explains its poor antimicrobial activity (active against only susceptible bacterial strains). " 2LMF resolved by NMR. "Its structure, dynamics, and antimicrobial and immune modulating activities have been characterized (Biochemistry 2012)." "Gram-negative bacterium: Escherichia coli DC2 (MIC=9 ?M);##Gram-positive bacteria: Staphylococcus aureus mprF (presence of carbonate) (MIC=3 ?M), S. aureu mprF (absence of carbonate) (MIC=24 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17012259##22185690 "FASEB J 2006; 20, 2068-2080.##Biochemistry. 2012 Jan 17;51(2):653-664. " "Yamasaki K et al. Gallo RL.##Wang G, Elliott M, Cogen AL, Ezell EL, Gallo RL, Hancock RE." "Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin.##Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins." DRAMP03599 GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK 45 "Human beta-defensin 3 (BD-3, hBD-3; Hbd3; Beta-defensin 103; Human, mammals, animals)" "P81534, Q8NFG6, Q9NPF6" Belongs to the beta-defensin family DEFB103A AND DEFB103 Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Combine helix and strand structure Contains three disulfide bonds and a short helical segment preceding a three-stranded antiparallel beta-sheet. 1KJ6?resolved by NMR. "Function: Exhibits antimicrobial activity against Gram-positive bacteria and the Gram-negative bacteria and the yeast C.albicans. Kills multiresistant S. aureus and vancomycin-resistant E. faecium. Has hemolytic activity. Tissue specificity: Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. Induction: By bacterial infection and by IFNG/IFN-gamma. PTM: Contains three disulfide bonds 11-40; 18-33; 23-41." "[Ref.11085990]Gram-negative bacteria: Escherichia coli DSM1103 (MIC=9.4 ?g/ml), Klebsiella pneumoniae DSM681 (MIC=25 ?g/ml), Pseudomonas aeruginosa DSM1128 (MIC=18.75 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=4.7 ?g/ml), Streptococcus pneumoniae DSM11865 (MIC=4.7 ?g/ml)." "[Ref.11085990] It has 9% hemolysis at 250 ?g/ml, 15% hemolysis at 500 ?g/ml against human erythrocytes." Cyclic Free Free "Disulfide bonds between Cys11 and Cys40,Cys18 and Cys33,Cys23 and Cys41." L No cytotoxicity information found Not found 15625724##11085990 Biopolymers. 2005;80(1):34-49.##J Biol Chem. 2001 Feb 23;276(8):5707-5713. "Schulz A, Klver E, Schulz-Maronde S, Adermann K.##Harder J, Bartels J, Christophers E, Schroder JM." "Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins.##Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic." DRAMP03642 GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIR 39 "Chicken heterophil peptides 1 (Antimicrobial peptide CHP1; Birds, animals)" P80389 Belongs to the beta-defensin family Not found Gallus gallus (Chicken) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Function: Bactericidal activity; inhibits S. aureus and E. coli. PTM: Contains three disulfide bonds 6-28; 13-34; 18-35." Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.7 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus (MIC=0.7 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys6 and Cys28,Cys13 and Cys34,Cys18 and Cys35." L No cytotoxicity information found Not found 7964174 J Leukoc Biol. 1994 Nov;56(5):661-665. "Evans EW, Beach GG, Wunderlich J, Harmon BG." Isolation of antimicrobial peptides from avian heterophils. DRAMP01376 GFMDTAKNAAKNVAVTLLDNLKCKITKAC 29 "Odorranain-F1 (OdF1; Frogs, amphibians, animals)" A6MBL3 Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Odorranain-F1 adopts 55% None Function: Odorranain-F1 exhibites antimicrobial activities against the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbiit red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=4.20 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2.10 g/ml), Bacillus subtilis (MIC=8.40 g/ml).##Yeast: Candida albicans (MIC=1.05 g/ml)." "[Ref.17272268] RCH=15.4 3.5% against rabbit red blood cells at 50 g/ml. RCH, red cell hemolysis." Cyclic Free Cyclization (Cys23 and Cys29) Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01378 GIFGKILGVGKKVLCGLSGVC 21 "Odorranain-H1 (OdH1; Frogs, amphibians, animals)" A6MBN4 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Odorranain-H1 adopts 50.3 -sheet structure in water solution. None Function: Odorranain-H1 exhibites antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbit red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=23.60 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=5.90 g/ml), Bacillus subtilis (MIC=5.90 g/ml).##Yeast: Candida albicans (MIC=11.80 g/ml)." "[Ref.17272268] RCH=21.6 7.3% against rabbit red blood cells. RCH, red cell hemolysis." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01386 VIPFVASVAAEMMQHVYCAASKKC 24 "Odorranain-P1a (OdP1a; Brevinin-1HS1; Brevinin-1-OA2; Frogs, amphibians, animals)" "A6MBQ8, A6MBQ6" Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Function: Odorranain-P1a exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Also has hemolytic activity against rabbit red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=3.50 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.50 g/ml), Bacillus subtilis (MIC=1.75 g/ml).##Yeast: Candida albicans (MIC=1.75 g/ml)." "[Ref.17272268] RCH=11.2 2.9% against rabbit red blood cells. RCH, red cell hemolysis." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP03682 FLPIIAKLLGGLL 13 "Vespid chemotactic peptide 5e (VCP 5e; Insects, animals)" P0C1M1 Belongs to the MCD family (Crabrolin subfamily) Not found Vespa magnifica "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (By similarity)." [Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml). [Ref.16330062]Little hemolytic activity up to 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom. DRAMP03683 FLIIRRPIVLGLL 13 "Vespid chemotactic peptide 5g (VCP 5g; Insects, animals)" P0C1M3 Belongs to the MCD family (Crabrolin subfamily) Not found Vespa magnifica "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (By similarity)." [Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=10 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=12.5 ?g/ml). [Ref.16330062]Little hemolytic activity up to 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom. DRAMP03684 FLPIPRPILLGLL 13 "Vespid chemotactic peptide 5f (VCP 5f; Insects, animals)" P0C1M2 Belongs to the MCD family (Crabrolin subfamily) Not found Vespa magnifica "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Mast cell degranulating peptide (By similarity). Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria and the Gram-positive bacteria. Also has antifungal activity. Tissue specificity: Expressed by the venom gland. PTM: C-terminal amidation (By similarity)." [Ref.16330062]Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=30 ?g/ml);##Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=5 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=25 ?g/ml). [Ref.16330062]Little hemolytic activity up to 50 g/ml against rabbit red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16330062 Toxicon. 2006 Feb;47(2):249-53. "Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R." Two families of antimicrobial peptides from wasp (Vespa magnifica) venom. DRAMP03688 FLGMIPGLIGGLISAFK 17 "TsAP-2 (T. serrulatus antimicrobial peptide 2; scorpions, arachnids, invertebrates, animals)" No entry found Not found Not found Tityus serrulatus (Brazilian yellow scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Anti-cancer" Not found Not found Not found None "Function: TsAP-2 was of high potency against the Gram-positive bacterium, Staphylococcus aureus and the yeast Candida albicans." Gram-positive bacterium: Staphylococcus aureus (MIC=5 ?M).##Yeast: Candida albicans (MIC=10 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23770440 Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8. "Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C." "Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities." DRAMP03706 FLFSLIPHAIGGLISAFK 18 "Antimicrobial peptide 1 (AamAP1; Arthropods, animals)" G8YYA5 Not found ap1 Androctonus amoreuxi (African fattail scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Causes hemolysis on horse erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: C-termianal amidation." Gram-positive bacterium: Staphylococcus aureus (MIC=20 ?M);##Gram-negative bacterium: Escherichia coli (MIC=150 ?M).##Yeast: Candida albicans (MIC=64 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 22484288 Peptides. 2012 Jun;35(2):291-299. "Almaaytah A, Zhou M, Wang L, Chen T, Walker B, Shaw C." "Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog." DRAMP03707 FPFSLIPHAIGGLISAIK 18 "Antimicrobial peptide 2 (AamAP2; Arthropods, animals)" G8YYA6 Not found ap2 Androctonus amoreuxi (African fattail scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Has antibacterial and antifungal activity. Causes hemolysis on horse erythrocytes. Tissue specificity: Expressed by the venom gland. PTM: C-termianal amidation." Gram-positive bacterium: Staphylococcus aureus (MIC=48 ?M);##Gram-negative bacterium: Escherichia coli (MIC=120 ?M).##Yeast: Candida albicans (MIC=64 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 22484288 Peptides. 2012 Jun;35(2):291-299. "Almaaytah A, Zhou M, Wang L, Chen T, Walker B, Shaw C." "Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog." DRAMP01392 GLLSGTSVRGSI 12 "Odorranain-V1 (OdV1; Frogs, amphibians, animals)" A6MBS7 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Function: Odorranain-V1 exhibites moderate antimicrobial activities against all of the tested microbes. Also has hemolytic activity against rabbit red cells "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=36.00 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=18.00 g/ml), Bacillus subtilis (MIC=18.00 g/ml).##Yeast: Candida albicans (MIC=9.00 g/ml)." "[Ref.17272268] RCH=23.9 4.7% against rabbit red blood cells. RCH, red cell hemolysis." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP01393 GLFGKSSVWGRKYYVDLAGCAKA 23 "Odorranain-W1 (OdW1; Frogs, amphibians, animals)" A6MBS8 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None Function: Odorranain-W1 has hemolytic activity against rabbit red cell. "[Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=12.60 g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.30 g/ml), Bacillus subtilis (MIC=6.30 g/ml).##Yeast: Candida albicans (MIC=3.15 g/ml)." "[Ref.17272268] RCH=17.6 2.2% against rabbit red blood cells. RCH, red cell hemolysis." Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17272268 Mol Cell Proteomics. 2007 May;6(5):882-894. "Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J." Anti-infection peptidomics of amphibian skin. DRAMP03729 KWFNEKSIQNKIDEKIGKNFLGGMAKAVVHKLAKNEFMCVANVDMTKSCDTHCQKASGEKGYCHGTKCKCGVPLSY 76 "Opiscorpine-1 (Arthropods, animals)" "Q5WR03, Q5WQZ8" Belongs to the long chain scorpion toxin family (Class 3 subfamily) Not found Opistophthalmus carinatus (African yellow leg scorpion) "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: The short amino-terminal segment of opiscorpine 1 (residues 1C35), named Jan-f3, has antimicrobial activity against fungi and the Gram-negative bacteria. Tissue specificity: Expressed by the venom gland. PTM: Contains three disulfide bonds (By similarity)." "Fungi: Fusarium culmorum IMI180420 (IC50=8.8 ?M), Fusarium oxysporum MUCL39789 (IC50=10.04 ?M).##Gram-negative bacterium: Escherichia coli JM109 (MIC=12 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15241551 Cell Mol Life Sci. 2004 Jul;61(14):1751-1763. "Zhu S, Tytgat J." "The scorpine family of defensins: gene structure, alternative polyadenylation and fold recognition." DRAMP03734 FKLGSFLKKAWKSKLAKKLRAKGKEMLKDYAKGLLEGGSEEVPGQ 45 "Parabutoporin (PP; Non-disulfide-bridged peptide 3.2, NDBP-3.2; Arthropods, animals)" P83312 Belongs to the scorpion BPP family Not found Parabuthus schlechteri (Scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity. Induces reversible G-protein dependent Ca2+ release from intracellular stores and increase Ca2+ influx in HL-60 cells. Induces the activation of the Rac pathway in granulocytes. Synergistically enhances the excitatory effects of short and long chain ion-channel-specific neurotoxins by interaction with the neuronal membranes. Tissue specificity: Expressed by the venom gland. NOTE: residue 11, 44, 55 are uncertainty." "[Ref.12354111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.1 ?M), Escherichia coli DH5a (MIC=3.1 ?M), Pseudomonas aeruginosa ATCC 257853 (MIC=6.3 ?M), Klebsiella pneumoniae ATCC 13833 (MIC=1.6 ?M), Salmonella choleraesuis ATCC 13311 (MIC=3.1 ?M), Haemophilus influenzae ATCC 19418 (MIC=3.1 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=6.3 ?M), Listeria monocytogenes NCTC 11994 (MIC=6.3 ?M), Micrococcus luteus ATCC 9341 (MIC=25 ?M);##Fungi: Neurospora crassa (MIC=2.5 ?M), Botrytis cinerea (MIC=3.5 ?M), Fusarium culmorum (MIC=0.3 ?M), Saccharomyces cerevisiae (MIC=2 ?M)." [Ref.12354111]50% hemolysis is induced by about 38 ?M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12354111##12457879##14575699##15245865 Eur J Biochem. 2002 Oct;269(19):4799-4810.##Toxicon. 2002 Dec;40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7;311(1):90-97.##Peptides. 2004 Jul;25(7):1079-1084. "Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, Thevissen K, Tytgat J, Van Eldere J, Van Der Walt J, Verdonck F.Willems J, Noppe W, Moerman L, van der Walt J, Verdonck F.##Moerman L, Verdonck F, Willems J, Tytgat J, Bosteels S.##Willems J, Moerman L, Bosteels S, Bruyneel E, Ryniers F, Verdonck F." "Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.##Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes.##Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells.##Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions." DRAMP03735 GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS 44 "Opistoporin-1 (OP1; Non-disulfide-bridged peptide 3.5; Opistoporin-3, OP3; Arthropods, animals)" "P83313, Q5VJS8, Q5VJT0" Belongs to the antimicrobial peptide scorpion family Not found Opistophthalmus carinatus (African yellow leg scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity. Tissue specificity: Expressed by the venom gland." "[Ref.12354111]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 ?M), Escherichia coli DH5a (MIC=6.3 ?M), Serratia marcescens ATCC 133880 (MIC=50 ?M), Pseudomonas aeruginosa ATCC 257853 (MIC=12.5 ?M), Klebsiella pneumoniae ATCC 13833 (MIC=6.3 ?M), Salmonella choleraesuis ATCC 13311 (MIC=25 ?M), Haemophilus influenzae ATCC 19418 (MIC=1.6 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=12.5 ?M), Bacillus subtilis IP 5832 (MIC=12.5 ?M), Listeria monocytogenes NCTC 11994 (MIC=12.5 ?M), Micrococcus luteus ATCC 9341 (MIC>50 ?M), Enterococcus faecalis ATCC 19433 (MIC=12.5 ?M), Staphylococcus aureus ATCC 292136.3 (MIC>50 ?M), Streptococcus pneumoniae ATCC 33400 (MIC=12.5 ?M), Nocardia asteroides ATCC 3308 (MIC>50 ?M);##Fungi: Neurospora crassa (IC50=0.8 ?M), Botrytis cinerea (IC50=3.1 ?M), Fusarium culmorum (IC50=0.8 ?M), Saccharomyces cerevisiae (IC50=2 ?M)." "[Ref.12354111]10% hemolytic activity at 10 ?M, 30% hemolytic activity at 100 ?M against human red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 12354111##12457879##14575699 Eur J Biochem. 2002 Oct;269(19):4799-4810.##Toxicon. 2002 Dec;40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7;311(1):90-97. "Moerman L, Bosteels S, Noppe W, Willems J, Clynen E, Schoofs L, Thevissen K, Tytgat J, Van Eldere J, Van Der Walt J, Verdonck F.Willems J, Noppe W, Moerman L, van der Walt J, Verdonck F.##Moerman L, Verdonck F, Willems J, Tytgat J, Bosteels S." "Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.##Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes.##Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells." DRAMP02828 GLFRRLRDSIRRGQQKILEKARRIGERIKDIFRG 34 "BMAP-34 (BMAP 34, bovine cathelicidin, cattle, ruminant, mammals, animals)" P56425 Belongs to the cathelicidin family. CATHL7 Bos taurus (Bovine) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Tissue specificity: Expressed in bone marrow myeloid cells, spleen and testis." "[Ref.9795251] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3 M), Staphylococcus aureus Cowan 1 (MIC=3 M), Staphylococcus aureus (MRSA, clinical isolate) (MIC=6 M), Staphylococcus epidermidis ATCC 12228 (MIC=1.5 M), Bacillus megaterium Bm 11 (MIC=3 M);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1.5 M), Escherichia coli ML-35 (MIC=1.5 M), Escherichia coli D21 (MIC=1.5 M), Escherichia coli D22 (MIC=1.5 M), Salmonella typhimurium ATCC 14028 (MIC=3 M), Salmonella enteritidis (clinical isolate) (MIC=3 M), Serratia marcescens ATCC 8100 (MIC=1.5 M), Pseudomonas aeruginosa ATCC 27853 (MIC48 M);##Fungus: Candida albicans (clinical isolate) (MIC>96 M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9409740##9795251 FEBS Lett. 1997 Nov 17;417(3):311-5.##Biochim Biophys Acta. 1998 Oct 23;1425(2):361-368. "Scocchi M, Wang S, Zanetti M.##Gennaro R, Scocchi M, Merluzzi L, Zanetti M." Structural organization of the bovine cathelicidin gene family and identification of a novel member.##Biological characterization of a novel mammalian antimicrobial peptide. DRAMP03748 FRFGSFLKKVWKSKLAKKLRSKGKQLLKDYANKVLNGPEEEAAAPAE 47 "Bradykinin-potentiating peptide BmK3 (Bpp BmK3; NDBP-3.3; Arthropods, animals)" Q9Y0X4 Belongs to the scorpion BPP family Not found Mesobuthus martensii (Manchurian scorpion) (Buthus martensii) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Alpha helix (predict) "The secondary structure prediction for BmKbpp reveals that BmKbpp is composed of an -helical structure from amino residues 3-35, followed by a coil-coiled region of three residues (NGP), and ended with an -helical region of 9 residues (ref.2)." None "Function: Amphipathic peptide that shows bradykinin potentiating activity and antimicrobial activities against bacteria and fungi. Has higher antibacterial activities against Gram-negative than against Gram-positive bacteria. Also inhibits NADPH oxidase-dependent superoxide production (IC50 is 0.4 ?M on granulocytes stimulated with PMA, IC50 is 0.51 ?M on HL-60 cells undifferentiated and IC50 is 0.53 ?M on HL-60 cells treated with DMSO). The C-terminal peptide shows a higher bradykinin potentiating activity than the complete peptide. Tissue specificity: Expressed by the venom gland. Miscellaneous: Shows hemolytic activity. Shows a alpha-helical structure. The genomic DNA coding for this protein is not a continuous sequence in the genome. The transcript of this protein may be generated by trans-splicing, by which exons from two independently transcribed pre-mRNAs are joined to form a single mature transcript." "[Ref.22115565]Gram-negative bacteria: Escherichia coli DH 5- (MIC=2.3 ?M), Haemophilus in?uenzae ATCC 31517 (MIC=3.2 ?M), Klebsiella pneumoniae ATCC 13882 (MIC=2.8 ?M), Salmonella enterica ATCC 8090 (MIC=2.3 ?M), Pseudomonas aeruginosa ATCC 9229 (MIC=4.7 ?M), Serratia marcescens ATCC 13880 (MIC=68.2 ?M);##Gram-positive bacteria: Bacillus subtilis ATCC 6051 (MIC=24.4 ?M), Listeria monocytogenes ATCC 35152 (MIC=5.7 ?M), Micrococcus luteus ATCC 9341 (MIC=20.3 ?M), Enterococcus faecalis ATCC 14508 (MIC=57.1 ?M), Nocardia asteroides ATCC 3308 (MIC>70 ?M), Staphylococcus aureus ATCC 14458 (MIC>70 ?M);##Fungi: Neurospora crassa FGSC 2489 (IC50=2 ?M), Botrytis cinerea ATCC 28387 (IC50=3.1 ?M), Fusarium culmorum ATCC 32973 (IC50=0.2 ?M)." "[Ref.22115565]3.5% hemolytic activity at 6 M, 11.2% hemolytic activity at 10 M, 22.5% hemolytic activity at 30 M, 33.9% hemolytic activity at 50 M against human red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10868911##22115565 IUBMB Life. 2000 Mar;49(3):207-210.##Peptides. 2012 Jan;33(1):44-51. "Zeng XC, Li WX, Peng F, Zhu ZH.##Zeng XC, Wang S, Nie Y, Zhang L, Luo X." "Cloning and characterization of a novel cDNA sequence encoding the precursor of a novel venom peptide (BmKbpp) related to a bradykinin-potentiating peptide from Chinese scorpion Buthus martensii Karsch.##Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides." DRAMP03750 IFGAIAGLLKNIF 13 "Venom antimicrobial peptide-6 (Meucin-13; NDBP-5; Arthropods, animals)" "E4VP07, E4VP35" Belongs to the scorpion NDBP 5 family Not found Mesobuthus eupeus (Lesser Asian scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Amphipathic peptide that exhibits extensive cytolytic activities against both prokaryotic and eukaryotic cells. Is more potent against Gram-positive bacteria (lethal concentration (LC=0.25-2.9 ?M) than against Gram-negative bacteria (LC=6.2->50 ?M), and fungi (LC=14.1->50 ?M). Shows hemolytic activity against rabbit erythrocytes and cytolysis against rat dorsal root ganglions. In vivo, intravenous injection into mice tail provokes uncomfortable symptoms with a death rate of 12.5%. Tissue specificity: Expressed by the venom gland." "[Ref.19088182]Gram-positive bacteria: Bacillus sp. DM-1 (MIC=2 ?M), Micrococcus luteus (MIC=2.9 ?M), Bacillus megaterium (MIC=0.25 ?M);##Gram-negative bacteria: Agrobacterium tumefaciens (MIC=11.8 ?M), Escherichia coli (MIC=7.90 ?M), Shewanella oneidensis (MIC=6.20 ?M), Stenotrophomonus sp. YC-1 (MIC=6.20 ?M);##Fungi: Beauveria spp. (MIC=14.1 ?M), Neurospora crassa (MIC=18.3 ?M), Candida albicans (MIC=42.8 ?M), Saccharomyces cerevisiae (MIC=18.3 ?M)." "[Ref.19088182]37.7% hemolytic activity at 6.25 M, 59.2% hemolytic activity at 12.5 M against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 19088182 FASEB J. 2009 Apr;23(4):1230-1245. "Gao B, Sherman P, Luo L, Bowie J, Zhu S." Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. DRAMP03751 FFGHLFKLATKIIPSLFQ 18 "Venom antimicrobial peptide-9 (Meucin-18; NDBP-5; Arthropods, animals)" E4VP50 Belongs to the ponericin-W family Not found Mesobuthus eupeus (Lesser Asian scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Alpha helix Not found None "Function: Amphipathic peptide that exhibits extensive cytolytic activities against both prokaryotic and eukaryotic cells. Is more potent against Gram-positive bacteria (lethal concentration (LC=1.5-10.9 ?M) than against Gram-negative bacteria (LC=6.2-50 ?M), and fungi (LC=25.1-8.3 ?M). Is lethal to the fungus Beauveria sp (LC=1.9 ?M), a highly lethal pathogenic fungus to insects and resistant to many AMPs. Shows hemolytic activity against rabbit erythrocytes and cytolysis against rat dorsal root ganglions. In vivo, intravenous injection into mice tail provokes uncomfortable symptoms with a death rate of 12.5%. Tissue specificity: Expressed by the venom gland." "[Ref.19088182]Gram-positive bacteria: Bacillus sp. DM-1 (MIC=0.60 ?M), Micrococcus luteus (MIC=0.60 ?M), Bacillus megaterium (MIC=0.25 ?M);##Gram-negative bacteria: Agrobacterium tumefaciens (MIC=6.00 ?M), Escherichia coli (MIC=2.40 ?M), Shewanella oneidensis (MIC=1.50 ?M), Stenotrophomonus sp. YC-1(MIC=2.60 ?M), Salmonella typhimurium (MIC=10.9 ?M);##Fungi: Beauveria spp.(MIC=1.9 ?M), Neurospora crassa (MIC=5.2 ?M), Candida albicans (MIC=25.1 ?M), Saccharomyces cerevisiae (MIC=25.1 ?M), Aspergillus fumigatus (MIC=8.3 ?M), Geotrichum candidum (MIC=3.5 ?M)." "[Ref.19088182]74% hemolytic activity at 6.25 M, 100% hemolytic activity at 12.5 M against rabbit red blood cells" Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 19088182 FASEB J. 2009 Apr;23(4):1230-1245. "Gao B, Sherman P, Luo L, Bowie J, Zhu S." Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. DRAMP03831 GLWNSIKIAGKKLFVNVLDKIRCKVAGGC 29 Palustrin-2ISb-des-C7 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=6.3 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=1.6 ?M), S. aureus (MRSA) (MIC=12.5 ?M).##Yeast: Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys23 and Cys29). Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-4 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03832 GLWDSIKIAGKKLFVNVLDKIRCKVAGGC 29 Palustrin-2ISb-des-C7-4D No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), S. aureus (MRSA) (MIC=12.5 ?M);##yeast Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys23 and Cys29). Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-5 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03833 GLWNSIKIAGKNLFVNVLDKIRCKVAGGC 29 Palustrin-2ISb-des-C7-12N No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=12.5 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 ?M), S. aureus (MRSA) (MIC=12.5 ?M);##yeast Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys23 and Cys29). Disulfide bond between Cys23 and Cys29. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-6 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03834 GLWNSIKIAGKKLFVNVLDKIRSKVAGGS 29 "Palustrin-2ISb-des-C7-23,29S" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-negative bacterium: Escherichia coli (MIC=3.1 ?M);##Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 ?M), S. aureus (MRSA) (MIC=25 ?M);##yeast Candida albicans (MIC=100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-7 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03835 GKKLFVNVLDKIRCKVAGGC 20 Palustrin-2ISb-des-C7-des-N9 No entry found Not found Not found Synthetic construct "Antimicrobial, Antifungal" Synthetic Not found Not found None Function: Possess antifungal activity. Yeast: Candida albicans (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys16 and Cys20). Disulfide bond between Cys16 and Cys20. L No cytotoxicity information found Not found 21911019 Peptides. 2011 Oct;32(10):2052-2057. "Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K." Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-8 family isolated from the skin of the endangered frog Odorrana ishikawae. DRAMP03852 GLARIVVIRVAR 12 G1 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=125 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=125 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03853 RGARIVVIRVAR 12 G2 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=31 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03854 RRARIVVIRVAR 12 R2 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=16 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03855 RLRRIVVIRVAR 12 R3 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03856 RLWRIVVIRVAR 12 W3 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.5 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03857 RLARRVVIRVAR 12 R5 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=63 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=16 ?g/ml), Enterococcus faecalis (MIC=125 ?g/ml).##Yeast: Candida albicans (MIC=125 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03858 RLARIVKIRVAR 12 K7 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=125 ?g/ml), Staphylococcus epidermidis (MIC=31 ?g/ml), Enterococcus faecalis (MIC=125 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03859 RLARIVVIRWAR 12 W10 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03860 RLARIVVIRVRR 12 R11 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03861 RLARIVVIRVAG 12 G12 (Bac2A variant through single amino acid substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=63 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=63 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=63 ?g/ml), Staphylococcus epidermidis (MIC=31 ?g/ml), Enterococcus faecalis (MIC=31 ?g/ml).##Yeast: Candida albicans (MIC=63 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03862 RLRRIVVIRVRR 12 Sub2 (Bac2A variant through two amino acids substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03863 RRWRIVVIRVRR 12 Sub3 (Bac2A variant through three amino acids substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2 ?g/ml), Escherichia coli (MIC=2.5 ?g/ml), Salmonella typhimurium (MIC=4 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.2 ?g/ml), Enterococcus faecalis (MIC=4 ?g/ml).##Yeast: Candida albicans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03864 RRWKIVVIRWRR 12 Sub5 (Bac2A variant through five amino acids substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=2 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=0.5 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=4 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03865 RWWKIWVIRWWR 12 Sub6 (Bac2A variant through six amino acids substitution) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: Optimized 12-mer peptides shows broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=31 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=8 ?g/ml), Staphylococcus epidermidis (MIC=1 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=31 ?g/ml).." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03866 KIWVIRWR 8 Bac8a (Bac2A variant) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=8 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=16 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03867 RIWVIRWR 8 Bac8b (Bac2A variant) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=16 ?g/ml), Escherichia coli (MIC=4 ?g/ml), Salmonella typhimurium (MIC=16 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=4 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=8 ?g/ml).##Yeast: Candida albicans (MIC=16 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03868 RIWVIWRR 8 Bac8c (Bac2A variant) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 ?g/ml), Escherichia coli (MIC=2 ?g/ml), Salmonella typhimurium (MIC=8 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=2 ?g/ml), Staphylococcus epidermidis (MIC=2 ?g/ml), Enterococcus faecalis (MIC=2 ?g/ml).##Yeast: Candida albicans (MIC=8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03869 RRWVIWRR 8 Bac8d (Bac2A variant) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None "Function: 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans. Chemical modification: C-terminal amidation." "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=250 ?g/ml), Escherichia coli (MIC=16 ?g/ml), Salmonella typhimurium (MIC=31 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=16 ?g/ml), Staphylococcus epidermidis (MIC=8 ?g/ml), Enterococcus faecalis (MIC=32 ?g/ml).##Yeast: Candida albicans (MIC=63 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366 Nat Biotechnol. 2005 Aug;23(8):1008-1012. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity. DRAMP03870 RLARIVVIRVAR 12 Bac2A (a linear variant of bovine dodecapeptide) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=50 ?g/ml), Escherichia coli (MIC=17 ?g/ml), Salmonella (MIC=34 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=17 ?g/ml), Staphylococcus epidermidis (MIC=4 ?g/ml), Enterococcus faecalis (MIC=17 ?g/ml).##Yeast: Candida albicans (MIC=9 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16041366##17052614 Nat Biotechnol. 2005 Aug;23(8):1008-1012.Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Volkmer-Engert R, Walter T, Hancock RE. Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." High-throughput generation of small antibacterial peptides with improved activity.Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP03930 KWKLFKKLKVLTTGL 15 Cecropin A (1-7)-melittin (6-13)hybrid peptide No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Escherichia coli D21 (MIC=2 ?M), Pseudomonas aeruginosa OT97 (MIC=8 ?M);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=1 ?M), Bacillus megaterium Bm11 (MIC=0.5 ?M), Staphylococcus aureus Cowan 1 (MIC=51 ?M), Streptococcus pyogenes (MIC=0.4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1733777 FEBS Lett. 1992 Jan 20;296(2):190-194. "Andreu D, Ubach J, Boman A, W??hlin B, Wade D, Merrifield RB, Boman HG." Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. DRAMP03933 IIYCNRRTGKCQRM 14 "I14M (truncated isoform of thanatin, residue 8-21)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-positive bacteria: Aerococcus viridans (MIC=1.2-2.5 ?M), Micrococcus luteus (MIC=5-10 ?M), Bacillus megaterium (MIC=10-20 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=20-40 ?M), Escherichia coli D31 (MIC=20-40 ?M), Klebsiella pneumoniae (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=20-40 ?M), Botrytis cinerea (MIC=10-20 ?M), Alternaria brassicicola (MIC=5-10 ?M), Fusarium culmorum (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8577744 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides." DRAMP03934 YCNRRTGKCQRM 12 "Y12M (truncated isoform of thanatin, residue 10-21)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-positive bacteria: Aerococcus viridans (MIC=20-40 ?M), Micrococcus luteus (MIC=20-40 ?M), Bacillus megaterium (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8577744 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides." DRAMP03935 VPIIYCNRRTGKCQRM 16 "V16M (truncated isoform of thanatin, residue 6-21)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-positive bacteria: Aerococcus viridans (MIC=1.2-2.5 ?M), Micrococcus luteus (MIC=2.5-5 ?M), Bacillus megaterium (MIC=5-10 ?M), Bacillus subtilis (MIC=20-40 ?M), Pediococcus acidilactici (MIC=20-40 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.6-1.2 ?M), Escherichia coli D31 (MIC=0.6-1.2 ?M), Klebsiella pneumoniae (MIC=2.5-5 ?M), Enterobacter cloacae (MIC=5-10 ?M), E. carotovora (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=10-20 ?M), Botrytis cinerea (MIC=10-20 ?M), Nectria haematococca (MIC=5-10 ?M), Trichoderma viride (MIC=20-40 ?M), Alternaria brassicicola (MIC=5-10 ?M), Fusarium culmorum (MIC=10-20 ?M), A. pisi (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8577744 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides." DRAMP03936 KPVPIIYCNRRTGKCQRM 18 "K18M (truncated isoform of thanatin, residue 4-21)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-positive bacteria: Aerococcus viridans (MIC=0.6-1.2 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Bacillus subtilis (MIC=20-40 ?M), Pediococcus acidilactici (MIC=20-40 ?M);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.3-0.6 ?M), Escherichia coli D31 (MIC=0.3-0.6 ?M), Escherichia coli 1106 (MIC=0.6-1.2 ?M), Salmonella typhimuriumn (MIC=1.2-2.5 ?M), Klebsiella pneumoniae (MIC=1.2-2.5 ?M), Enterobacter cloacae (MIC1.2-2.5 ?M), E. carotovora (MIC=20-40 ?M), Pseudomonas aeruginosa (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=2.5-5 ?M), Botrytis cinerea (MIC=1.2-2.5 ?M), Nectria haematococca (MIC=5-10 ?M), Trichoderma viride (MIC=2.5-5 ?M), Alternaria brassicicola (MIC=2.5-5 ?M), Fusarium culmorum (MIC=5-10 ?M), A. pisi (MIC=10-20 ?M), Fusarium oxysporumn (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8577744 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides." DRAMP03937 GSKKPVPIIYCNRRTGKC 18 "G18C (truncated isoform of thanatin, residue 1-18)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 ?M), Micrococcus luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=5-10 ?M), Bacillus subtilis (MIC=5-10 ?M), Pediococcus acidilactici (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=10-20 ?M), Botrytis cinerea (MIC=5-10 ?M), Nectria haematococca (MIC=5-10 ?M), Trichoderma viride (MIC=20-40 ?M), Alternaria brassicicola (MIC=5-10 ?M), Fusarium culmorum (MIC=10-20 ?M), A. pisi (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8577744 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides." DRAMP03938 GSKKPVPIIYCNRRTGKCQ 19 "G19Q (truncated isoform of thanatin, residue 1-19)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 ?M), Micrococcus luteus (MIC=5-10 ?M), Bacillus megaterium (MIC=5-10 ?M), Pediococcus acidilactici (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=10-20 ?M), Botrytis cinerea (MIC=5-10 ?M), Nectria haematococca (MIC=5-10 ?M), Trichoderma viride (MIC=10-20 ?M), Alternaria brassicicola (MIC=5-10 ?M), Fusarium culmorum (MIC=10-20 ?M), A. pisi (MIC=20-40 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8577744 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides." DRAMP03939 GSKKPVPIIYCNRRTGKCQR 20 "G20R (truncated isoform of thanatin, residue 1-20)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 ?M), Micrococcus luteus (MIC=2.5-5 ?M), Bacillus megaterium (MIC=2.5-5 ?M), Bacillus subtilis (MIC20-40 ?M), Pediococcus acidilactici (MIC=20-40 ?M).##Fungi: Neurospora crassa (MIC=5-10 ?M), Botrytis cinerea (MIC=5-10 ?M), Nectria haematococca (MIC=2.5-5 ?M), Trichoderma viride (MIC=10-20 ?M), Alternaria brassicicola (MIC=5-10 ?M), Fusarium culmorum (MIC=10-20 ?M), A. pisi (MIC=10-20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8577744 Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225. "Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA." "Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides." DRAMP03954 MTKGDTKVMKCVLEVISDSLSKPSPMPVSPECLETLQGDERILSVLRHQNL 51 Rat CGA7?57 No entry found Not found Not found Synthetic construct "Antimicrobial, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Fungi: Neurospora crassa (MIC=10 ?g/ml), Alternaria brassicicola (MIC=20 ?g/ml), Nectria haematococca (MIC=10 ?g/ml), Fusarium culmorum (MIC=20 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10753865 J Biol Chem. 2000 Apr 14;275(15):10745-10753. "Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH." "Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A." DRAMP03955 STALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKK 81 Human recombinant Ser-Thr-Ala-CGA1-78 peptide (hrVS-1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Micrococcus luteus (MIC=30 ?M), Bacillus megaterium (MIC=30 ?M).##Fungi: Neurospora crassa (MIC=10 ?M), Alternaria brassicicola (MIC=1 ?M), Nectria haematococca (MIC=3 ?M), Fusarium culmorum (MIC=5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10753865 J Biol Chem. 2000 Apr 14;275(15):10745-10753. "Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH." "Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A." DRAMP03957 RILSILRHQNLLKE 14 CGA47-60 (hrVS-1-derived peptide) No entry found Not found Not found Synthetic construct "Antimicrobial, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Fungi: Neurospora crassa (MIC=7 ?M), Aspergillus fumigatus (MIC=50 ?M), Alternaria brassicicola (MIC=10 ?M), Nectria haematococca (MIC=7 ?M), Fusarium culmorum (MIC=20 ?M), F. oxyporum (MIC=50 ?M), Trichophyton mentagrophytes (MIC=50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10753865 J Biol Chem. 2000 Apr 14;275(15):10745-10753. "Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH." "Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A." DRAMP03958 TLRGDERILSILRHQNLLKE 20 CGA41-60 (hrVS-1-derived peptide) No entry found Not found Not found Synthetic construct "Antimicrobial, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Fungi: Neurospora crassa (MIC=100 ?M), Nectria haematococca (MIC=30 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10753865 J Biol Chem. 2000 Apr 14;275(15):10745-10753. "Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH." "Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A." DRAMP03959 TLRGDERILSILRHQNLLKELQDLALQGAK 30 CGA41-70 (hrVS-1-derived peptide) No entry found Not found Not found Synthetic construct "Antimicrobial, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Fungi: Neurospora crassa (MIC=7 ?M), Alternaria brassicicola (MIC=7 ?M), Nectria haematococca (MIC=7 ?M), Fusarium culmorum (MIC=10 ?M), F. oxyporum (MIC=30 ?M), Trichophyton mentagrophytes (MIC=30 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10753865 J Biol Chem. 2000 Apr 14;275(15):10745-10753. "Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH." "Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A." DRAMP03960 RILSILRHQNLLKELQDLALQGAK 24 CGA47-70 (hrVS-1-derived peptide) No entry found Not found Not found Synthetic construct "Antimicrobial, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Fungi: Neurospora crassa (MIC=5 ?M), Aspergillus fumigatus (MIC=30 ?M), Alternaria brassicicola (MIC=10 ?M), Nectria haematococca (MIC=7 ?M), Fusarium culmorum (MIC=10 ?M), F. oxyporum (MIC=30 ?M), Trichophyton mentagrophytes (MIC=30 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10753865 J Biol Chem. 2000 Apr 14;275(15):10745-10753. "Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH." "Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A." DRAMP04019 RAVAVIIRLRRV 12 Bac014 (Scrambled Variants of Bac2A) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=23 ?g/ml), Escherichia coli (MIC=11 ?g/ml), Salmonella (MIC=11 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=23 ?g/ml), Staphylococcus epidermidis (MIC=6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04020 RRAAVVLIVIRR 12 Bac020 (Scrambled Variants of Bac2A) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=11 ?g/ml), Escherichia coli (MIC=6 ?g/ml), Salmonella (MIC=23 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=11 ?g/ml), Staphylococcus epidermidis (MIC=1.5 ?g/ml).##Yeast: Candida albicans (MIC=11 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04021 VRLRIRVAVIRA 12 Bac034 (Scrambled Variants of Bac2A) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=25 ?g/ml), Escherichia coli (MIC=3 ?g/ml), Salmonella (MIC=12 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermidis (MIC=3 ?g/ml).##Yeast: Candida albicans (MIC=12 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04022 VRFRIRVAVIRA 12 "F3 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04023 VRWRIRVAVIRA 12 "W3 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=12 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04024 VRLWIRVAVIRA 12 "W4 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC>50 ?g/ml), Escherichia coli (MIC=6 ?g/ml), Salmonella (MIC>50 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?g/ml), Staphylococcus epidermidis (MIC=3 ?g/ml).##Yeast: Candida albicans (MIC=50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04025 VRLRIRVAVRRA 12 "R10 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=12 ?g/ml), Escherichia coli (MIC=6 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04026 VRLRIRVAVIRK 12 "K12 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=3 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=3 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04027 VQLRIRVRVIRK 12 "opt1 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=3 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04028 VRLRIRVRVIRK 12 "opt2 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=3 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=0.8 ?g/ml).##Yeast: Candida albicans (MIC=3 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04029 KQFRIRVRVIRK 12 "opt3 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=3 ?g/ml), Salmonella (MIC=6 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=1.6 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04030 KRFRIRVRVIRK 12 "opt4 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=3 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=0.8 ?g/ml).##Yeast: Candida albicans (MIC=12 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04031 KRWRIRVRVIRK 12 "opt5 (multiple amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial activiy against Gram-negative and Gram-positive bacteria. "Gram-negative bacteria: Pseudomonas aeruginosa (MIC=3 ?g/ml), Escherichia coli (MIC=1.6 ?g/ml), Salmonella (MIC=3 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=3 ?g/ml), Staphylococcus epidermidis (MIC=0.8 ?g/ml).##Yeast: Candida albicans (MIC=6 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17052614 Chem Biol. 2006 Oct;13(10):1101-1107. "Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE." Sequence requirements and an optimization strategy for short antimicrobial peptides. DRAMP04075 AKKVFKRLEKLFSKIQNDK 19 Antimicrobial peptide HP (2-20) P56029 Not found rplA Synthetic construct (amino acid substitution) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Alpha helix (1 helices; 11 residues) Not found 1P0G resolved by NMR. Function: Peptides originating from the N-terminal end of L1 have antibacterial activity against bacteria such as E. coli and Bacillus megaterium and modest antifungal activities. Has no effect on H. pylori itself. Peptides are not hemolytic against mammalian cells. These peptides may be released in the stomach during altruistic lysis to kill other fast growing bacteria. "[Ref.16255716]Gram-positive bacteria: Bacillus subtilis (MIC=3.13 ?g/ml), Staphylococcus epidermidis (MIC=6.25 ?g/ml), Staphylococcus aureus (MIC=12.5 ?g/ml), Listeria monocytogenes (MIC=6.25 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ?g/ml), Salmonella typhimurium (MIC=1.56 ?g/ml), Proteus vulgaris (MIC=6.25 ?g/ml), Pseudomonas aeruginosa (MIC=6.25 ?g/ml), Escherichia coli O157 (MIC=12.5 ?g/ml);##Fungi: Trichosporon beigelii (MIC=3.13 ?g/ml), Candida albicans (MIC>25 ?g/ml), Saccharomyces cerevisiae (MIC>25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC=12.5 ?g/ml), Fusarium moniliforme (MIC=25 ?g/ml)." [Swiss_Prot Entry P56029]Non-hemolytic against mammalian cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Phospholipids 16255716##PubMed ID is not available##PubMed ID is not available Biochem J. 2006 Feb 15;394(Pt 1):105-114.##Submitted (SEP-2004) to the PDB data bank.##To be published "Lee KH, Lee DG, Park YK, Harm KS, Kim YM.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM." "Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Structure of antimicrobial peptide, HP (2-20) and its analogues derived from Helicobacter pylori, as determined by 1H NMR spectroscopy.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy." DRAMP04076 AKKVFKRLEKLFSKIQNWK 19 Anal 1 (antimicrobial peptide HP (2-20)analogue) P56029 Not found Not found Synthetic construct (amino acid substitution) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Alpha helix (1 helices; 14 residues) Not found 1P0J resolved by NMR. Function: Has antibacterial and antifungal activiy. "Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=3.13 ?g/ml), Staphylococcus aureus (MIC=3.13 ?g/ml), Listeria monocytogenes (MIC=0.78 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=0.78 ?g/ml), Salmonella typhimurium (MIC=0.39 ?g/ml), Proteus vulgaris (MIC=3.13 ?g/ml), Pseudomonas aeruginosa (MIC=3.13 ?g/ml), Escherichia coli O157 (MIC=6.25 ?g/ml).##Fungi: Trichosporon beigelii (MIC=1.56 ?g/ml), Candida albicans (MIC=25 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC=6.25 ?g/ml), Fusarium moniliforme (MIC=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16255716##PubMed ID is not available Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published "Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM." "Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy." DRAMP04077 AKKVFKRLEKLFSKIWNDK 19 Anal 2 (antimicrobial peptide HP (2-20)analogue) P56029 Not found Not found Synthetic construct (amino acid substitution) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Alpha helix (1 helices; 14 residues) Not found 1P0L resolved by NMR. Function: Has antibacterial and antifungal activiy. "Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=3.13 ?g/ml), Staphylococcus aureus (MIC=6.25 ?g/ml), Listeria monocytogenes (MIC=1.56 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ?g/ml), Salmonella typhimurium (MIC=0.78 ?g/ml), Proteus vulgaris (MIC=3.13 ?g/ml), Pseudomonas aeruginosa (MIC=6.25 ?g/ml), Escherichia coli O157 (MIC=6.25 ?g/ml).##Fungi: Trichosporon beigelii (MIC=1.56 ?g/ml), Candida albicans (MIC=25 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC=6.25 ?g/ml), Fusarium moniliforme (MIC=25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16255716##PubMed ID is not available Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published "Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM." "Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy." DRAMP04078 AKKVFKRLEKLFSKIWNWK 19 Anal 3 (antimicrobial peptide HP (2-20)analogue) P56029 Not found Not found Synthetic construct (amino acid substitution) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Alpha helix (1 helices; 14 residues) Not found 1P0O resolved by NMR. Function: Has antibacterial and antifungal activiy. "Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=3.13 ?g/ml), Staphylococcus aureus (MIC=1.56 ?g/ml), Listeria monocytogenes (MIC=0.39 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=1.56 ?g/ml), Salmonella typhimurium (MIC=0.39 ?g/ml), Proteus vulgaris (MIC=3.13 ?g/ml), Pseudomonas aeruginosa (MIC=3.13 ?g/ml), Escherichia coli O157 (MIC=3.13 ?g/ml).##Fungi: Trichosporon beigelii (MIC=1.56 ?g/ml), Candida albicans (MIC=12.5 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=25 ?g/ml), Aspergillus fumigatus (MIC=25 ?g/ml), Botrytis cinerea (MIC=3.13 ?g/ml), Fusarium moniliforme (MIC=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16255716##PubMed ID is not available Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published "Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM." "Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy." DRAMP04079 AKKVFKRLEKSFSKIQNDK 19 Anal 4 (antimicrobial peptide HP (2-20)analogue) P56029 Not found Not found Synthetic construct (amino acid substitution) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Alpha helix (1 helices; 13 residues) Not found 1P5K resolved by NMR. Function: Has antibacterial and antifungal activiy. "Gram-positive bacteria: Bacillus subtilis (MIC=6.25 ?g/ml), Staphylococcus epidermidis (MIC>12.5 ?g/ml), Staphylococcus aureus (MIC>12.5 ?g/ml), Listeria monocytogenes (MIC>12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=12.5 ?g/ml), Salmonella typhimurium (MIC=12.5 ?g/ml), Proteus vulgaris (MIC>12.5 ?g/ml), Pseudomonas aeruginosa (MIC=12.5 ?g/ml), Escherichia coli O157 (MIC>12.5 ?g/ml).##Fungi: Trichosporon beigelii (MIC=12.5 ?g/ml), Candida albicans (MIC>25 ?g/ml), Saccharomyces cerevisiae (MIC>25 ?g/ml), Aspergillus flavus (MIC>50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC>50 ?g/ml), Fusarium moniliforme (MIC>50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16255716##PubMed ID is not available Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published "Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM." "Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy." DRAMP04080 AKKVSKRLEKLFSKIQNDK 19 Anal 5 (antimicrobial peptide HP (2-20)analogue) P56029 Not found Not found Synthetic construct (amino acid substitution) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Alpha helix (1 helices; 12 residues) Not found 1P5L resolved by NMR. Function: Has antibacterial and antifungal activiy. "Gram-positive bacteria: Bacillus subtilis (MIC=3.13 ?g/ml), Staphylococcus epidermidis (MIC=12.5 ?g/ml), Staphylococcus aureus (MIC>12.5 ?g/ml), Listeria monocytogenes (MIC>12.5 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=6.25 ?g/ml), Salmonella typhimurium (MIC=12.5 ?g/ml), Proteus vulgaris (MIC>12.5 ?g/ml), Pseudomonas aeruginosa (MIC=12.5 ?g/ml), Escherichia coli O157 (MIC=6.25 ?g/ml).##Fungi: Trichosporon beigelii (MIC=12.5 ?g/ml), Candida albicans (MIC>25 ?g/ml), Saccharomyces cerevisiae (MIC>25 ?g/ml), Aspergillus flavus (MIC>50 ?g/ml), Aspergillus fumigatus (MIC>50 ?g/ml), Botrytis cinerea (MIC>50 ?g/ml), Fusarium moniliforme (MIC>50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16255716##PubMed ID is not available Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published "Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM." "Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy." DRAMP04081 AKKVFKRLEKLFSKIFNFK 19 Anal 6 (antimicrobial peptide HP (2-20)analogue) P56029 Not found Not found Synthetic construct (amino acid substitution) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Alpha helix Not found None Function: Has antibacterial and antifungal activiy. "Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=6.25 ?g/ml), Staphylococcus aureus (MIC=3.13 ?g/ml), Listeria monocytogenes (MIC=0.78 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ?g/ml), Salmonella typhimurium (MIC=0.39 ?g/ml), Proteus vulgaris (MIC=3.125 ?g/ml), Pseudomonas aeruginosa (MIC=6.25 ?g/ml), Escherichia coli O157 (MIC=6.25 ?g/ml).##Fungi: Trichosporon beigelii (MIC=3.13 ?g/ml), Candida albicans (MIC>25 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC=50-25 ?g/ml), Botrytis cinerea (MIC=12.5 ?g/ml), Fusarium moniliforme (MIC=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16255716##PubMed ID is not available Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published "Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM." "Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy." DRAMP04082 AKKVFKRLEKLFSKIYNYK 19 Anal 7 (antimicrobial peptide HP (2-20)analogue) P56029 Not found Not found Synthetic construct (amino acid substitution) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Alpha helix Not found None Function: Has antibacterial and antifungal activiy. "Gram-positive bacteria: Bacillus subtilis (MIC=1.56 ?g/ml), Staphylococcus epidermidis (MIC=3.13 ?g/ml), Staphylococcus aureus (MIC=3.13 ?g/ml), Listeria monocytogenes (MIC=0.78 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 ?g/ml), Salmonella typhimurium (MIC=0.39 ?g/ml), Proteus vulgaris (MIC=6.25-3.13 ?g/ml), Pseudomonas aeruginosa (MIC=3.13 ?g/ml), Escherichia coli O157 (MIC=3.13 ?g/ml).##Fungi: Trichosporon beigelii (MIC=1.56 ?g/ml), Candida albicans (MIC=12.5 ?g/ml), Saccharomyces cerevisiae (MIC=25 ?g/ml), Aspergillus flavus (MIC=50 ?g/ml), Aspergillus fumigatus (MIC=50-25 ?g/ml), Botrytis cinerea (MIC=6.25 ?g/ml), Fusarium moniliforme (MIC=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16255716##PubMed ID is not available Biochem J. 2006 Feb 15;394(Pt 1):105-114.##To be published "Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.##Lee KH, Lee DG, Park YK, Harm KS, Kim YM." "Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.##Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy." DRAMP04096 EQEENVVKIQAFWKGYKQRKEYM 23 2IQ2 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Displays antimicrobial activity against bacteria and yeast C. albicans. Gram-negative bacterium: Escherichia coli (MIC=2.1 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=32 ?M).##Yeast: Candida albicans (MIC=28 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23238369 Biochimie. 2013 Apr;95(4):875-880. "McLean DT, Lundy FT, Timson DJ." IQ-motif peptides as novel anti-microbial agents. DRAMP04097 DNTDSVVKIQSWFRMATARKSYL 23 2IQ3 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Displays antimicrobial activity against bacteria and yeast C. albicans. Gram-negative bacterium: Escherichia coli (MIC=1.2 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=26 ?M).##Yeast: Candida albicans (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23238369 Biochimie. 2013 Apr;95(4):875-880. "McLean DT, Lundy FT, Timson DJ." IQ-motif peptides as novel anti-microbial agents. DRAMP04098 ANVGFVIQLQARLRGFLVRQKFA 23 3IQ1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Displays antimicrobial activity against bacteria and yeast C. albicans. Gram-negative bacterium: Escherichia coli (MIC=1.7 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=1.7 ?M).##Yeast: Candida albicans (MIC>94 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23238369 Biochimie. 2013 Apr;95(4):875-880. "McLean DT, Lundy FT, Timson DJ." IQ-motif peptides as novel anti-microbial agents. DRAMP04099 TWLPAVIKIQAHWRGYRQRKIYL 23 3IQ2 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Displays antimicrobial activity against bacteria and yeast C. albicans. Gram-negative bacterium: Escherichia coli (MIC=1.9 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=1.6 ?M).##Yeast: Candida albicans (MIC=25 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23238369 Biochimie. 2013 Apr;95(4):875-880. "McLean DT, Lundy FT, Timson DJ." IQ-motif peptides as novel anti-microbial agents. DRAMP04100 ANLDAIIKIQAWARMWAARRQYL 23 3IQ3 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Displays antimicrobial activity against bacteria and yeast C. albicans. Gram-negative bacterium: Escherichia coli (MIC=2 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=11 ?M).##Yeast: Candida albicans (MIC>89 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23238369 Biochimie. 2013 Apr;95(4):875-880. "McLean DT, Lundy FT, Timson DJ." IQ-motif peptides as novel anti-microbial agents. DRAMP04101 KNVNSIVKIQAFFRARKAQDDYR 23 3IQ4 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Displays antimicrobial activity against bacteria and yeast C. albicans. Gram-negative bacterium: Escherichia coli (MIC=3.5 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=4.6 ?M).##Yeast: Candida albicans (MIC=30 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23238369 Biochimie. 2013 Apr;95(4):875-880. "McLean DT, Lundy FT, Timson DJ." IQ-motif peptides as novel anti-microbial agents. DRAMP04147 WFRKQLKW 8 L10 No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram-, Antifungal" Synthetic Not found Not found None Function: Has antibacterial and antifungal activity. "Gram-negative bacteria: Escherichia coli ATCC 25923 (MIC=0.8 ?M), Klebsiella pneumoniae (MIC=3.35 ?M), Acinetobacter sp. (MIC=3.35 ?M), Psudomonas aruginosa (MIC=6.71 ?M).##Fungi: Candida albicans ATCC SC5314 (MIC=10.49 ?M), C. tropicalis ATCC 13803 (MIC=20.98 ?M), C. parapsilosis ATCC 22019 (MIC=5.24 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipopolysaccharide (LPS)-binding 23026014 Biochim Biophys Acta. 2013 Feb;1828(2):677-686. "Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S." "A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida." DRAMP04159 RIKRFWPVVIRTVVAGYNLYRAIKK 25 LR2 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04160 RIKRFWPVVIRTVVAGYNLYRAIK 24 LR3 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=7.032 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=2.344 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=0.586 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04161 RIKRFWPVVIRTVVAGYNLYRAI 23 LR4 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=37.5 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=37.5 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=9.375 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04162 RIKRFWPVVIRTVVAGYNLYRA 22 LR5 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database Gram-positive bacterium: Staphylococcus aureus ATCC25923 (MIC=75 ?g/ml);##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=4.688 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=4.688 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04163 RIKRFWPVVIRTVVAGYNLYR 21 LR6 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04164 RIKRFWPVVIRTVVAGYNLY 20 LR7 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04165 RIKRFWPVVIRTVVAGYNL 19 LR8 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04166 RIKRFWPVVIRTVVAGYN 18 LR9 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04167 RIKRFWPVVIRTVVAGY 17 LR10 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04168 RIKRFWPVVIRTVVAG 16 LR11 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04169 RIKRFWPVVIRTVV 14 LR13 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04170 RIKRFWPVVIRT 12 LR15 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04171 RIKRFWPVVIR 11 LR16 (homologue of Pc-CATH1) No entry found Not found Not found Synthetic construct (De novo design) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Synthetic Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacteria: Bacillus subtilis (MIC=4.688 ?g/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 ?g/ml).##Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 ?g/ml).##Yeast: Candida albicans ATCC2002 (MIC=2.344 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Natural Products and Bioprospecting. 2012 Apr;2(2):81-86. "Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai." Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1. DRAMP04528 TCRYWCKTPENQTYCCEDEREIPSKVGLKPGKCPPVRPVCPPTRGFFEPPKTCSNDGSCYGADKCCFDRCLGEHVCKPIQTRG 83 CrusEs (cDNA encoding crustin-like peptide) No entry found Not found Not found "Chinese mitten crab, Eriocheir sinensis" "Antibacterial, Antifungal, Antiviral, In, Anti-Gram+, Antimicrobial" Not found Not found Not found None Function: CrusEs is a potent antibacterial protein against Gram-positive bacteria infection. "Gram-positive bacteria: M. luteus (MIC=0.23 ?M), B. subtilis (MIC=0.11 ?M), B. thuringiensis (MIC=0.11 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20144896 Dev Comp Immunol. 2010 Jul;34(7):734-740. "Mu C, Zheng P, Zhao J, Wang L, Zhang H, Qiu L, Gai Y, Song L." "Molecular characterization and expression of a crustin-like gene from Chinese mitten crab, Eriocheir sinensis." DRAMP04665 KPFKKLEKVGRNIRDGIIKAGPAVAVIGQATSIARPTGK 39 Px-cec1 No entry found Not found Not found Plutella xylostella (Diamondback moth) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Alpha helix (CD) A circular dichroism (CD) analysis revealed that the recombinant Px-cec1 mainly contained -helixes. None "Function: Recombinant Px-cec1 exhibites a broad spectrum of anti-microbial properties against fungi, Gram-positive and Gram-negative bacteria, but it does not exhibit hemolytic activity against human erythrocytes." "[Ref.22921836]Gram-positive bacterium: S. aureus (MIC=2 ?M);##Gram-negative bacteria: E. coli (MIC=0.1 ?M), Pseudomonas fluorescent (MIC=1.1 ?M), Salmonella choleraesuis (MIC=2.1 ?M);##Fungi: Aureobasidium pullulans (MIC=4.0 ?M), Aspergillus flavus (MIC=14.5 ?M), Aspergillus fumigatus (MIC=16.0 ?M), Aspergillus niger (MIC=14.6 ?M), Fusarium oxysporum (MIC=8.0 ?M)." [Ref.22921836]Non-hemolytic activity against human erythrocytes. Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22921836 Protein Expr Purif. 2012 Oct;85(2):230-238. "Jin F, Sun Q, Xu X, Li L, Gao G, Xu Y, Yu X, Ren S." "cDNA cloning and characterization of the antibacterial peptide cecropin 1 from the diamondback moth, Plutella xylostella L." DRAMP04671 TDHQMAQSACIGVSQDNAYASAIPRDCHGG 30 Myticusin-1 No entry found Not found Not found Mytilus coruscus "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Myticusin-1 exhibites stronger anti-microbial properties against Gram-positive bacteria more than Gram-negative bacteria and fungus. "Gram-negative bacteria: Escherichia coli (MIC=6.7-12.5 ?M), Vibrio Parahaemolyticus (MIC>25.0 ?M), Pseudomonas aeruginosa (MIC>25.0 ?M), Vibrio.harveyi (MIC=12.5-25.0 ?M).##Gram-positive bacteria: Bacillus subtilis (MIC=1.2-2.5 ?M), Staphylococcus aureus (MIC=2.5-5.0 ?M), Sarcina luteus (MIC=1.2-2.5 ?M), Bacillus megaterium (MIC=2.5-5.0 ?M).##Fungi: Candida albicans (MIC=6.7-12.5 ?M), Monilia albican (MIC=12.5-25.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23247103 Fish Shellfish Immunol. 2013 Feb;34(2):610-616. "Liao Z, Wang XC, Liu HH, Fan MH, Sun JJ, Shen W." Molecular characterization of a novel antimicrobial peptide from Mytilus coruscus. DRAMP04676 MFTLKKPLLLLFFLGTISLSLCQEERDADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC 75 Brevinin-2HS2A E7EKE0 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Odor frog) (Rana hainanensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Has antimicrobial activity against some Gram-positive bacteria and fungi but has no activity against a range of Gram- negative bacteria except P.faecalis. Has extremely low hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.22450466]Gram-positive bacteria: S.aureus ATCC 25923 (MIC=19 ?M), B.licheniformis X39 (MIC=37.5 ?M) and R.rhodochrous X15 (MIC=9.5 ?M);##Gram-negative bacterium: P. faecalis X29 (MIC=9.5 ?M);##Fungi: C. albicans ATCC 2002 (MIC=19 ?M), slime mold 090223 (MIC=37.5 ?M)." [Ref.22450466]LC50=300 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP04677 MFTMKKPLLLIVLLGIISLSLCEQERAADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC 75 Brevinin-2HS2B E7EKE1 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Odorrana hainanensis (Odor frog) (Rana hainanensis) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Transcript level Not found Not found None "Function: Has antimicrobial activity against some Gram-positive bacteria and fungi but has no activity against a range of Gram- negative bacteria except P. faecalis. Has low hemolytic activity against human erythrocytes. Tissue specificity: Expressed by the skin glands." "[Ref.22450466]Gram-positive bacteria: S.aureus ATCC 25923 (MIC=19 ?M), B. licheniformis X39 (MIC=37.5 ?M) and R. rhodochrous X15 (MIC=9.5 ?M);##Gram-negative bacterium: P. faecalis X29 (MIC=9.5 ?M);##Fungi: C. albicans ATCC 2002 (MIC=19 ?M), slime mold 090223 (MIC=37.5 ?M)." [Ref.22450466]LC50=300 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22450466 Peptides. 2012 Jun;35(2):285-290. "Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J." "Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis." DRAMP04679 FLPFLIPALTSLISSL 16 Senegalin L0P323 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Kassina senegalensis (Senegal running frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Not found Not found None Function: Antimicrobial peptide with activity against the Gram-positive bacterium S. aureus NCTC 10788 and the yeast C. albicans NCPF 1467. Ineffective against the Gram-negative bacterium E. coli NCTC 10418. Induces a dose-dependent contraction of rat urinary bladder smooth muscle (EC50=2.9 nM) and a dose-dependent relaxation of rat tail artery smooth muscle (EC50=37.7 nM). Gram-positive bacterium: S. aureus NCTC 10788 (MIC=50 ?M). Yeast: C. albicans NCPF 1467 (MIC=150 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23430307 Amino Acids. 2013 May;44(5):1347-1355. "Wang H, Li R, Xi X, Meng T, Zhou M, Wang L, Zhang Y, Chen T, Shaw C." "Senegalin: a novel antimicrobial/myotropic hexadecapeptide from the skin secretion of the African running frog, Kassina senegalensis." DRAMP00224 KQQLATEAESAGPIL 15 BTL (Bacteriocin) No entry found Not found Not found Bacillus subtilis B-TL2 (Gram-positive bacteria) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: The peptide exhibits strong inhibitory activity against mycelial growth of Bipolaris maydis, Alternaria brassicae, Aspergillus niger, Cercospora personata. Biophysicochemical properties: The purified BTL displays thermostability, almost retaining 100% activity at 100 degrees C for 15 min." "Fungi: Bipolaris maydis, Alternaria brassicae, Aspergillus niger, Cercospora personata." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18241956 Peptides. 2008 Mar;29(3):350-355. "Zhang B, Xie C, Yang X." A novel small antifungal peptide from Bacillus strain B-TL2 isolated from tobacco stems. DRAMP00235 MINRTDCNENSYLEIHNNEGRDTLCFANAGTMPVAIYGVNWVESGNNVVTLQFQRNLSDPRLETITLQKWGSWNPGHIHEILSIRIY 87 AFP1 (Bacteriocin) No entry found Not found Not found Streptomyces tendae Tu901 (Gram-positive bacteria) "Antimicrobial, Antifungal" Not found Combine helix and strand structure "Mature AFP1 comprises 86 residues and contains two antiparallel beta-sheets (five and four beta-strands each), that pack against each other in a parallel beta-sandwich." 1G6E resolved by NMR. "Function: AFP1 is a recently discovered anti-fungal, chitin-binding protein." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 10601197##11350173 J Bacteriol. 1999 Dec;181(24):7421-7429.##J Mol Biol. 2001 May 11;308(4):765-782. "Bormann C, Baier D, H?rr I, Raps C, Berger J, Jung G, Schwarz H.##Campos-Olivas R, H?rr I, Bormann C, Jung G, Gronenborn AM." "Characterization of a novel, antifungal, chitin-binding protein from Streptomyces tendae T?901 that interferes with growth polarity.##Solution structure, backbone dynamics and chitin binding of the anti-fungal protein from Streptomyces tendae TU901." DRAMP00249 YSLQMGATAIKQVKKLFKKKGG 22 Pln149 (Plantaricin 149; Bacteriocin; Derivatives: Pln149a) No entry found Not found Not found Lactobacillus plantarum NRIC 149 (Gram-positive bacteria) "Antimicrobial, Antibacterial, Antifungal" Not found Alpha helix Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrance 17266050 J. Fermentation Bioeng. 1994;77(3):277-282. "Kato T, Matsuda T, Ogawa E, Ogawa H, Kato H, Doi U." "Plantaricin-149, a bacteriocin produced by Lactobacillus plantarum NRIC 149." DRAMP00252 VNPSYRLDPESRPQCEAHCGQLGMRLGAIVIMGTATGCVCEPKEAATPESR 51 AdDLP (A. dehalogenans defensin-like peptide; Bacteriocin) No entry found Not found Not found Anaeromyxobacter dehalogenans (Gram-negative bacteria) "Antibacterial, Antifungal, Antiparasitic, Antimicrobial" Not found Not found "Circular dichroism (CD) analysis indicates that recombinant AdDLP adopts a typical structural feature of eukaryotic defensins, which is also consistent with an ab initio structure model predicted using I-TASSER algorithm." None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19615342 Biochem Biophys Res Commun. 2009 Sep 18;387(2):393-398. "Gao B, Rodriguez MD, Lanz-Mendoza H, Zhu S." "AdDLP, a bacterial defensin-like peptide, exhibits anti-Plasmodium activity." DRAMP00264 EQCREEEDDR 10 Coconut antifungal peptide (Plants) No entry found Not found Not found Cocos nucifera "Antimicrobial, Antifungal, Antiviral" Not found Not found Not found None Function: Also has HIV-1 reverse transcriptase activity (IC50=52.5 ?M) "Fungi: Fusarium oxysporum, Mycosphaerella arachidicola (IC50=1.2 ?M), Physalospora piricola." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16308082 Peptides. 2005 Dec;26(12):2392-2396. "Wang HX, Ng TB." An antifungal peptide from the coconut. DRAMP00265 EALYNSEDLYEETSDSDD 18 Putative antimicrobial protein 1 (Ls-AMP1; Plant defensin) P86895 Not found Not found Lippia sidoides (Pepper-rosmarin) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: May possess antifungal activity. Caution: Antifungal activity was tested using a fraction containing a number of different peptides. It is not clear which peptide actually has antifungal activity." Fungi: Botrytis cinerea. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21210197 Protein J. 2011 Jan;30(1):32-38. "Moreira JS, Almeida RG, Tavares LS, Santos MO, Viccini LF, Vasconcelos IM, Oliveira JT, Raposo NR, Dias SC, Franco OL." Identification of botryticidal proteins with similarity to NBS-LRR proteins in rosemary pepper (Lippia sidoides Cham.) flowers. DRAMP00266 SPPEAAYGPGNTNSDSGDK 19 Putative antimicrobial protein 2 (Ls-AMP2; Plant defensin) P86896 Not found Not found Lippia sidoides (Pepper-rosmarin) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: May possess antifungal activity. Caution: Antifungal activity was tested using a fraction containing a number of different peptides. It is not clear which peptide actually has antifungal activity." Fungi: Botrytis cinerea. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21210197 Protein J. 2011 Jan;30(1):32-38. "Moreira JS, Almeida RG, Tavares LS, Santos MO, Viccini LF, Vasconcelos IM, Oliveira JT, Raposo NR, Dias SC, Franco OL." Identification of botryticidal proteins with similarity to NBS-LRR proteins in rosemary pepper (Lippia sidoides Cham.) flowers. DRAMP00267 ESGINLQGDATLANN 15 Antifungal lectin AMML (AMML; Plant defensin) P85004 Not found Not found Astragalus mongholicus (Huang qi) (Astragalus membranaceus varmongholicus) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Lectin that binds strongly to galactose, lactose, D-raffinose, L-rhamnose and cellobiose, and less strongly to D-glucose, D-xylose and L-arabinose. Does not bind D-galacturonic acid, D-fructose, D-mannose, D-ribose, L-sorbose, maltose and sucrose. Has hemagglutinating activity towards human type O and rabbit erythrocytes. Has strong antifungal activity against B. cinera, and weaker antifungal activity against D. turcia, F. oxysporum and Colletorichum sp. but not against Rhizoctonia solani and Mycosphaerella arachidicola. Miscellaneous: Hemagglutinating activity stable when incubated at 65 degrees Celsius for 30 minutes. Hemagglutinating activity is reduced by 50% when incubated at 75 degrees Celsius for 30 minutes and is abolished by incubation at 85 degrees Celsius for 30 minutes. Hemagglutinating activity is stable between pH 4.5 and 7.5, but is completely inhibited by incubation below pH 3.0 or above pH 10." "Fungi: Botrytis cinerea (IC50=1.2 ?M), Drechslera turcia, Fusarium oxysporum and Colletorichum sp." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Galactose and Glucose 16140255 Arch Biochem Biophys. 2005 Oct 1;442(1):72-81. "Yan Q, Jiang Z, Yang S, Deng W, Han L." A novel homodimeric lectin from Astragalus mongholicus with antifungal activity. DRAMP00268 QGIGVGDNDGKRGKR 15 Antifungal protein Pr-2 (Pr-2; Plant defensin) P86796 Not found Not found Cucurbita maxima (Pumpkin) (Winter squash) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has strong antifungal activity. Lacks antifungal activity against P.verrucosum var. verrucosum. Lacks antibacterial activity against the Gram-negative bacterium E.coli and against the Gram-positive bacterium S.aureus. Has very low hemolytic activity against human erythrocytes. Increases fungal cell membrane permeability, probably by disrupting the membrane structure." "[Ref.19807165]Fungi: Botrytis cinerea (EC50=20 ?M), Candida albicans (EC50=20 ?M), Colletotrichum coccodes (EC50=10 ?M), Fusarium oxysporum (EC50=10 ?M), Fusarium solani (EC50=10 ?M), Trichoderma harzianum (EC50=20 ?M), Trichoderma viride (EC50=20 ?M), Aspergillus fumigatus EC50=40 ?M), Aspergillus parasiticus (EC50=80 ?M), Didymella bryoniae (EC50=40 ?M)." [Ref:19807165]0% hemolytic activity at 80 ?M and 8% hemolytic activity at 160 ?M against huamn red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19807165 J Agric Food Chem. 2009 Oct 14;57(19):9299-9304. "Park SC, Kim JY, Lee JK, Hwang I, Cheong H, Nah JW, Hahm KS, Park Y." Antifungal mechanism of a novel antifungal protein from Pumpkin rinds against various fungal pathogens. DRAMP00269 LDSLSFSYNNFEEDD 15 Antifungal protein 1 (GAFP-1; Plant defensin) P86920 Not found Not found Arachis hypogaea (Peanut) "Antimicrobial, Antifungal" Protein level Not found Not found None Function: Has strong antifungal activity against fungal phytopathogens. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Submitted (MAY-2011) to UniProtKB Indira S. GAFP-1 from roots of Arachis hypogeae L. DRAMP00270 ATFTIRNNCPYTIWAAAVPGGGRRLNSGGTWTINVAPGTA 40 Osmotin (CpOsm; Plant defensin) P86363 Belongs to the thaumatin family Not found Calotropis procera (Roostertree) (Asclepias procera) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity. Miscellaneous: On the 2D-gel the determined pI of isoform 1 is: 8.9, its MW is: 22 kDa. On the 2D-gel the determined pI of isoform 2 is: 9.1, its MW is: 22 kDa." "Fungi: Fusarium solani (IC50=67.0 ?g/ml), Colletotrichum gloeosporioides (IC50=32.1 ?g/ml), Neurospora isolate (IC50=57.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21334906 Plant Physiol Biochem. 2011 Jul;49(7):738-743. "de Freitas CD, Nogueira FC, Vasconcelos IM, Oliveira JT, Domont GB, Ramos MV." "Osmotin purified from the latex of Calotropis procera: Biochemical characterization, biological activity and role in plant defense." DRAMP00271 ATFTIRNNXPYTVWAAASPGGGRRLDMARIWGRTNXNFD 39 Osmotin-like protein (Thaumatin-like protein; Plant defensin) P83491 Belongs to the thaumatin family Not found Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: May be an important antifungal protein. PTM: Contains intrachain disulfide bonds." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Plant Physiol. Biochem. 2001;39:1047-1055. "Subroto T, de Vries H, Schuringa J.J, Soedjanaatmadja U.M.S, Hofsteenge J, Jekel P.A, Beintema J.J." Enzymic and structural studies on processed proteins from the vacuolar (lutoid-body) fraction of latex of Hevea brasiliensis. DRAMP00272 AKITFTNNHPRTIWP 15 Thaumatin-like protein (Plants) P83957 Belongs to the thaumatin family Not found Castanopsis chinensis (Chinese chinquapin) (Kweilin chestnut) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Comment: No comments found on DRAMP database "Fungi: Botrytis cinerea, Fusarium oxysporum (IC50=0.5 ?M), Mycosphaerella arachidicola, Psylla piricola.##HIV-1 reverse transcriptase (IC50=1.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12565869 Biochem Biophys Res Commun. 2003 Feb 7;301(2):364-370. "Chu KT, Ng TB." Isolation of a large thaumatin-like antifungal protein from seeds of the Kweilin chestnut Castanopsis chinensis. DRAMP00273 ANFEIVNNCPYTVWAAASPGGGRRLDRGQT 30 Thaumatin-like protein (Plants) P83959 Belongs to the thaumatin family Not found Phaseolus vulgaris (Kidney bean) (French bean) "Antimicrobial, Antifungal" Protein level Not found Not found None Comment: No comments found on DRAMP database "Fungi: Coprinus comatus, Fusarium oxysporum, Pleurotus ostreatus." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10486265 Biochem Biophys Res Commun. 1999 Sep 16;263(1):130-134. "Ye XY, Wang HX, Ng TB." First chromatographic isolation of an antifungal thaumatin-like protein from French bean legumes and demonstration of its antifungal activity. DRAMP00274 QKIQEIDLQTYLQPQ 15 Amaryllin (Plant defensin) P86781 Not found Not found Amaryllis belladonna (Naked lady lily) "Antimicrobial, Antifungal" Protein level Not found Not found None Function: Has antifungal activity. Fungi: Aspergillus flavus and Fusarium oxysporum. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19478451 Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):635-637. "Kumar S, Singh N, Sinha M, Kaur P, Srinivasan A, Sharma S, Singh TP." "Isolation, purification, crystallization and preliminary crystallographic studies of amaryllin, a plant pathogenesis-related protein from Amaryllis belladonna." DRAMP00276 YSYKKIDCGGACAARCRLSSRPRLCNRACGTCCARCNCVPPGTSGNTETCPCYASLTTHGNKRKCP 66 Snakin-2 (StSN2; Cys-rich; Plant defensin) "Q93X17, A1YN11, Q948Z5" Not found SN2 Solanum tuberosum (Potato) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Bridge Not found None "Function: Has an antimicrobial activity. Causes a rapid aggregation of both Gram-positive and Gram-negative bacteria, but the antimicrobial activity is not correlated with the capacity to aggregate bacteria. Tissue specificity: Expressed in tubers, stems, flowers, shoot apex and leaves, but not in roots or stolons. Induction: Locally up-regulated by abscisic acid, wounding and infection with compatible fungus. Down-regulated by gibberellic acid or infection with virulent bacteria. No responses to ethylene or abiotic stresses. PTM: Six disulfide bonds may be present." "Gram-positive bacteria: Clavibacter michiganensis (EC50=4 ?M), Ralstonia solanacearum (EC50=15 ?M).##Fungi: pathogens Rhizobium meliloti (EC50=8 ?M), Botrytis cinerea (EC50=2 ?M), Fusarium solani (EC50=2 ?M), Fusarium culmorum (EC50=2 ?M), Fusarium oxysporum f.sp. conglutinans (EC50=10 ?M), Fusarium oxysporum f.sp.lycopersici (EC50=20 ?M), Plectosphaerella cucumerina (EC50=10 ?M), Colletotrichum graminicola (EC50=10 ?M), Colletotrichum lagenarium (EC50=10 ?M), Bipolaris maydis (EC50=20 ?M), Aspergillus flavus (EC50=20 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11891250 Plant Physiol. 2002 Mar;128(3):951-961. "Marta Berrocal-Lobo, Ana Segura, Manuel Moreno, Gemma Lpez, Francisco Garca-Olmedo, Antonio Molina" "Snakin-2, an antimicrobial peptide from potato whose gene is locally induced by wounding and responds to pathogen infection." DRAMP00277 DICTNCCAGTKGCNTTSANGAFICEGQSDPKKPKACPLNCDPHIAYA 47 Potamin-1 (PT-1; Plants) P84813 Belongs to the protease inhibitor I20 Not found Solanum tuberosum (Potato) "Antimicrobial, Antifungal, Antibacterial, Anti-Gram+" Protein level Not found Not found None "Function: Inhibitor of serine proteases chymotrypsin, papain and trypsin. Has strong antifungal activity against C. albicans and R.solani. Has antibacterial activity against the Gram-positive bacterium C.michiganense, but Non-antibacterial activity against the Gram-positive bacterium S. aureus. Lacks hemolytic activity against human erythrocytes. PTM: Contains four disulfide bonds (By similarity)." [Ref.15809084]Fungi: Candida albicans(MIC =100M) and Rhizoctonia solani(MIC =100M);##Gram-positive bacterium: Clavibacter michiganensis(MIC =50M) [Ref:15809084]Non-hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15809084 Biochem Biophys Res Commun. 2005 May 13;330(3):921-927. "Kim JY, Park SC, Kim MH, Lim HT, Park Y, Hahm KS." Antimicrobial activity studies on a trypsin-chymotrypsin protease inhibitor obtained from potato. DRAMP00278 LPSDATLVLDQTGKELDARL 20 Antifungal protein J (AFP-J; Plants) P84794 Belongs to the protease inhibitor I3 Not found Solanum tuberosum (Potato) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Inhibitor of serine proteases chymotrypsin, pepsin and trypsin. Has strong antifungal activity. Non-hemolytic activity against human erythrocytes." "[Ref.16076139]Fungi: Candida albicans TIMM 1768(MIC=6.25g/mL)), Saccharomyces cerevisiae KCTC 7296(MIC=6.25g/mL)), Trichosporon beigelii KCTC 7707(MIC=6.25g/mL))" [Ref:16076139]Non-hemolytic activity against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16076139 J Agric Food Chem. 2005 Aug 10;53(16):6491-6496. "Park Y, Choi BH, Kwak JS, Kang CW, Lim HT, Cheong HS, Hahm KS." Kunitz-type serine protease inhibitor from potato (Solanum tuberosum L. cv. Jopung). DRAMP00280 LIYAKVECLTTGVRTYVGKQSWPELVGTKGKTAAATIDKENTHVTAVLCPPLTTLAACRTFDFRCDRVRVLINRIGGVVTKTPTVG 86 Trypsin inhibitor (FtTI; Plant defensin) P86971 Not found Not found Fagopyrum tataricum (Tartarian buckwheat) (Polygonum tataricum) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Serine protease inhibitor which is active against trypsin. Displays strong antifungal activity against a number of phytopathogenic fungi. Biophysicochemical properties: pH dependence (Optimum pH is 8.0 at 37 degrees Celsius. Maintains over 90% of its inhibitory activity from pH 3 to 10); Temperature dependence (Active between 10 and 60 degrees Celsius. 84% activity retained when heated for 30 minutes at 80 degrees Celsius. Incubation at temperatures above 80 degrees Celsius rapidly decreases inhibitory activity). PTM: Contains two disulfide bonds 8-65; 49-58." "Fungi: M. melonis, A. cucumerina, A. solani, C. glaeosporioides and P. capsici." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21544554 Appl Biochem Biotechnol. 2011 May 5. "Ruan JJ, Zhou ML, Chen H, Shao JR." Identification and Characterization of a Trypsin Inhibitor from Fagopyrum tataricum Seeds. DRAMP00282 GPMRIAEARHCESLSHRFKGPCTRDSNCASVCETERFSGGNCHGFRRRCFCTKPC 55 Defensin-like protein P322 (Probable protease inhibitor P322; Plant defensin) P20346 Belongs to the DEFL family Not found Solanum tuberosum (Potato) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available "Plant Molecular Biology. 1988, 11(3):255-269." "Stiekema WJ, Heidekamp F, Dirkse WG, van Beckum J, de Haan P, ten Bosch C, Louwerse JD." Molecular cloning and analysis of four potato tuber mRNAs. DRAMP00283 RECQSQSHRYKGACVHDTNCASVCQTEGFSGGKCVGFRGRCFCTKAC 47 Defensin Ec-AMP-D1 (Plant defensin) P86518 Belongs to the DEFL family Not found Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity. Inhibits hyphal development in P. infestans (IC50=25.5 ?g/ml), but not release of zoospores. At concentrations above 100 ?g/ml, induces morphological changes such as lysis of hyphae and sporangia in P. infestans. PTM: Contains four disulfide bonds (By similarity)." "Fungi: Fusarium graminearum (IC50=15 ?g/ml), Fusarium oxysporum (IC50=102 ?g/ml), F. verticillioides (IC50=8.5 ?g/ml), Diplodia maydis (IC50=12.5 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18625284 Biochimie. 2008 Nov-Dec;90(11-12):1667-1673. "Odintsova TI, Rogozhin EA, Baranov Y, Musolyamov AKh, Yalpani N, Egorov TA, Grishin EV." Seed defensins of barnyard grass Echinochloa crusgalli (L.) Beauv. DRAMP00284 RVCMGKSQHHSFPCISDRLCSNECVKEEGGWTAGYCHLRYCRCQKAC 47 Defensin-like protein 1 (SI alpha-1; Plant defensin) P21923 Belongs to the DEFL family Not found Sorghum bicolor (Sorghum) (Sorghum vulgare) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity (By similarity). PTM: Contains four disulfide bonds 3-47; 14-36; 20-41; 24-43." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1995329##7705336 FEBS Lett. 1991 Feb 11;279(1):101-104.##Eur J Biochem. 1995 Mar 1;228(2):250-256. "Bloch C Jr, Richardson M.##Nitti G, Orr S, Bloch C Jr, Morhy L, Marino G, Pucci P." A new family of small (5 kDa) protein inhibitors of insect alpha-amylases from seeds or sorghum (Sorghum bicolar (L) Moench) have sequence homologies with wheat gamma-purothionins.##Amino acid sequence and disulphide-bridge pattern of three gamma-thionins from Sorghum bicolor. DRAMP00285 RVCMGKSAGFKGLCMRDQNCAQVCLQEGWGGGNCDGVMRQCKCIRQCW 48 Defensin-like protein 2 (SI alpha-2; Plant defensin) P21924 Belongs to the DEFL family Not found Sorghum bicolor (Sorghum) (Sorghum vulgare) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity (By similarity). PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1995329 FEBS Lett. 1991 Feb 11;279(1):101-104. "Bloch C Jr, Richardson M." A new family of small (5 kDa) protein inhibitors of insect alpha-amylases from seeds or sorghum (Sorghum bicolar (L) Moench) have sequence homologies with wheat gamma-purothionins. DRAMP00286 RVCRRRSAGFKGLCMSDHNCAQVCLQEGWGGGNCDGVIRQCKCIRQC 47 Defensin-like protein 3 (SI alpha-3; Plant defensin) P21925 Belongs to the DEFL family Not found Sorghum bicolor (Sorghum) (Sorghum vulgare) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity (By similarity). PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1995329##7705336 FEBS Lett. 1991 Feb 11;279(1):101-104.##Eur J Biochem. 1995 Mar 1;228(2):250-256. "Bloch C Jr, Richardson M.##Nitti G, Orr S, Bloch C Jr, Morhy L, Marino G, Pucci P." A new family of small (5 kDa) protein inhibitors of insect alpha-amylases from seeds or sorghum (Sorghum bicolar (L) Moench) have sequence homologies with wheat gamma-purothionins.##Amino acid sequence and disulphide-bridge pattern of three gamma-thionins from Sorghum bicolor. DRAMP00287 RVCRRRSAGFKGLCMSDHNCAQVCLQEGWGGGNCDGVMRQCKCIRQC 47 Defensin-like protein 21 (SI alpha-2.1; Plant defensin) Q09198 Belongs to the DEFL family Not found Sorghum bicolor (Sorghum) (Sorghum vulgare) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity (By similarity). PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7705336 Eur J Biochem. 1995 Mar 1;228(2):250-256. "Nitti G, Orr S, Bloch C Jr, Morhy L, Marino G, Pucci P." Amino acid sequence and disulphide-bridge pattern of three gamma-thionins from Sorghum bicolor. DRAMP00288 RECQSQSHRYKGACVHDTNCASVCQTEGFSGGKCVGFRGRCFCTKHC 47 Defensin Ec-AMP-D2 (Plant defensin) P86519 Belongs to the DEFL family Not found Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity. Inhibits spore germination in Fusarium oxysporum (IC(50)=102 ??g/ml). Inhibits hyphal development in P. infestans (IC(50)=50 ??g/ml). Does not induce morphological changes such as lysis of hyphae and sporangia in P. infestans. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18625284 Biochimie. 2008 Nov-Dec;90(11-12):1667-1673. "Odintsova TI, Rogozhin EA, Baranov Y, Musolyamov AKh, Yalpani N, Egorov TA, Grishin EV." Seed defensins of barnyard grass Echinochloa crusgalli (L.) Beauv. DRAMP00289 RLCRVRGTRGHCFNDHGCDKVCTREGFVRGKCNGILRRCICDRQC 45 Defensin-like protein (Gamma-thionin; Plant defensin) B5LZ79 Belongs to the DEFL family Not found Gymnadenia conopsea (Fragrant orchid) (Orchis conopsea) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity (By similarity). PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available##PubMed ID is not available Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.##Submitted (JUL-2008) to UniProtKB. "Not found##Mukherjee G, Sen SK." "Not found##Purification, characterization, and antifungal activity of chitinase from Streptomyces venezuelae P(10)." DRAMP00290 KTCENLSDSFKGPCIPDGNCNKHCKEKEHLLSGRCRDDFRCWCTRNC 47 Defensin Lc-def (Plant defensin) "B3F051, P85530" Belongs to the DEFL family Not found Lens culinaris subsp. culinaris (Cultivated lentil) (Lens esculenta) "Antimicrobial, Antifungal" Protein level Combine helix and strand structure Not found 2LJ7 resolved by NMR. "Function: Has antifungal activity against the phytopathogenic fungus Aspergillus niger VKM F-2259, but not against A.alternatia VKM F- 3047. Does not inhibit trypsin or chymotrypsin. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18468512##PubMed ID is not available Biochem Biophys Res Commun. 2008 Jul 11;371(4):860-865.##To be Published. "Finkina EI, Shramova EI, Tagaev AA, Ovchinnikova TV.##Shenkarev Z, Mineev K, Gizatullina A, Finkina E, Arseniev A, Ovchinnikova T." A novel defensin from the lentil Lens culinaris seeds.##Solution structure of defensin Lc-def from germinated lentil (Lens Culinaris) seeds. DRAMP00291 RTCESQSHRFKGACLSDTNCASVCQTEGFPAGDCKGARRRCFCVKPC 47 Defensin-like protein (Gamma-thionin homolog; Plant defensin) A3FPF2 Belongs to the DEFL family Not found Nelumbo nucifera (Sacred lotus) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Has antifungal activity (By similarity). PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available##16972135 Submitted (FEB-2007) to the EMBL/GenBank/DDBJ database##Curr Microbiol. 2006 Oct;53(4):265-269. "Not found##Mukherjee G, Sen SK." "Not found##Purification, characterization, and antifungal activity of chitinase from Streptomyces venezuelae P(10)." DRAMP00292 RVCESQSHGFHGLCNRDHNCALVCRNEGFSGGRCKRSRRCFCTRIC 46 Defensin-like protein (8.4 kDa sulfur-rich protein; Plant defensin) Q07502 Belongs to the DEFL family Not found Glycine max (Soybean) (Glycine hispida) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Has antifungal activity (By similarity). PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8278516 Plant Physiol. 1993 Feb;101(2):699-700. "Choi Y, Choi YD, Lee JS." Nucleotide sequence of a cDNA encoding a low molecular weight sulfur-rich protein in soybean seeds. DRAMP00293 RICRRRSAGFKGPCVSNKNCAQVCMQEGWGGGNCDGPLRRCKCMRRC 47 Gamma1-hordothionin (Gamma 1-H; Plant defensin) P20230 Belongs to the DEFL family Not found Hordeum vulgare (Barley) "Antimicrobial, Antifungal" Protein level Combine helix and strand structure "Gamma 1-H adopts a well-defined triple-stranded antiparallel beta-sheet (residues 1-6, 31-34, and 39-47), an alpha-helix (residues 16-28), and the corresponding connecting loops. Three disulfide bridges are located in the hydrophobic core holding together the alpha-helix and the beta-sheet and forming a cysteine-stabilized alpha-helical (CSH) motif." 1GPT resolved by NMR. "Function: Inhibits protein translation in cell-free systems. PTM: Contains four disulfide bonds 3-47; 14-34; 20-21; 24-43. Caution: Was initially thought to be a thionin." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2176600##8380707 Eur I Biochem 1990;194:533-539.##Biochemistry. 1993 Jan 19;32(2):715-724. "Mendez E, Moreno A, Colilla F.J, Pelaez F, Limas G.G, Mendez R, Soriano F, Salinas M, de Haro C.##Bruix M, Jim?nez MA, Santoro J, Gonz?lez C, Colilla FJ, M?ndez E, Rico M." "Primary structure and inhibition of protein synthesis in eukaryotic cell-free system of a novel thionin, gamma-hordothionin, from barley endosperm.##Solution structure of gamma 1-H and gamma 1-P thionins from barley and wheat endosperm determined by 1H-NMR: a structural motif common to toxic arthropod proteins." DRAMP00294 YKRGGGGWGGGGGWKGGGGGGGGWKGGGGGGKGGGG 36 Glycine-rich protein GWK (Plants) P84064 Not found Not found Cucumis melo (Muskmelon) "Antimicrobial, Antifungal" Protein level Not found Not found None Function: Possesses antifungal activity against a number of phytopathogenic fungi. Fungi: Hordeum sativum and F. culmorum. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Submitted (AUG-2004) to UniProtKB "Vassilevski AA, Egorov TA, Grishin EV." Unknown DRAMP00295 ADPTFGFTPLGLSEKANLQIMKAYD 25 Soybean toxin 27 kDa chain (SBTX 27 kDa chain; Plant defensin) P86520 Not found Not found Glycine max (Soybean) (Glycine hispida) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Involved in plant defense. Has antifungal activity against C. sojina but not A. niger and F. solani. Does not have urease or hemagglutination activities. Does not inhibit trypsin. Injection into mice produces toxic effects such as dyspnea, tonic-clonic convulsion and death. Subunit structure Heterodimer of a 27 kDa subunit and a 17 kDa subunit; disulfide-linked. Tissue specificity: Expressed in seeds, leaves, roots and stem (at protein level). Induction: In seeds, induced by jasmonate. Post-translational modification: SBTX is known to be glycosylated but it is not known which one of its two subunits is modified; contains 5% carbohydrates. Toxic dose: LD50 is 5.6 mg/kg by intraperitoneal injection into mice. Miscellaneous: On the 2D-gel the determined pI of SBTX is: 8.2, its MW is: 44 kDa. Biophysicochemical properties: pH dependence (Activity decreases below pH 5.5 and above pH 8.0)." Fungi: C. sojina. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18328522 Toxicon. 2008 May;51(6):952-963. "Vasconcelos IM, Morais JK, Siebra EA, Carlini CR, Sousa DO, Beltramini LM, Melo VM, Oliveira JT." "SBTX, a new toxic protein distinct from soyatoxin and other toxic soybean [Glycine max] proteins, and its inhibitory effect on Cercospora sojina growth." DRAMP00296 PNPKVFFDMTIGGQSAGRIVMEEYA 25 Soybean toxin 17 kDa chain (SBTX 17 kDa chain; Plant defensin) P86548 Not found Not found Glycine max (Soybean) (Glycine hispida) "Antimicrobial, Antifungal, Cytotoxic" Protein level Not found Not found None "Function: Involved in plant defense. Has antifungal activity against C.sojina but not A.niger and F.solani. Does not have urease or hemagglutination activities. Does not inhibit trypsin. Injection into mice produces toxic effects such as dyspnea, tonic-clonic convulsion and death. Subunit structure: Heterodimer of a 27 kDa subunit and a 17 kDa subunit; disulfide-linked. Tissue specificity: Expressed in seeds, leaves, roots and stem (at protein level). Induction: In seeds, induced by jasmonate. Post-translational modification: SBTX is known to be glycosylated but it is not known which one of its two subunits is modified; contains 5% carbohydrates. Toxic dose: LD50 is 5.6 mg/kg by intraperitoneal injection into mice. Miscellaneous: On the 2D-gel the determined pI of SBTX is: 8.2, its MW is: 44 kDa. Biophysicochemical properties: pH dependence (Activity decreases below pH 5.5 and above pH 8.0). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18328522 Toxicon. 2008 May;51(6):952-963. "Vasconcelos IM, Morais JK, Siebra EA, Carlini CR, Sousa DO, Beltramini LM, Melo VM, Oliveira JT." "SBTX, a new toxic protein distinct from soyatoxin and other toxic soybean [Glycine max] proteins, and its inhibitory effect on Cercospora sojina growth." DRAMP00300 PGAGSQEERMQGQMEGQDFSHEERFLSMVRE 31 Antifungal protein 1 (Pa-AFP1; Plant defensin) B3EWF0 Not found Not found Passiflora alata (Winged-stem passion flower) (Fragrant granadilla) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Has antifungal activity against C. gloeosporioides but not against Botrytis cinerea and Fusarium sp. or against various yeasts. Has no antibacterial activity. Subunit structure: Heterodimer; disulfide-linked. PTM: Disulfide bonds." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20955745 Peptides. 2011 May;32(5):868-874. "Ribeiro SM, Almeida RG, Pereira CA, Moreira JS, Pinto MF, Oliveira AC, Vasconcelos IM, Oliveira JT, Santos MO, Dias SC, Franco OL." Identification of a Passiflora alata Curtis dimeric peptide showing identity with 2S albumins. DRAMP00303 ACGGGGGDVGSLISASLFDQMLKYRNDPRCCXXGF 35 Basic endochitinase CH1 (Plant defensin) P29137 Belongs to the glycosyl hydrolase 19 family (Chitinase class I subfamily) Not found Castanea sativa (Sweet chestnut) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16653058 Plant Physiol. 1992 Oct;100(2):778-783. "Collada C, Casado R, Fraile A, Aragoncillo C." Basic Endochitinases Are Major Proteins in Castanea sativa Cotyledons. DRAMP00304 SIGFDGLNDPDIVAR 15 Endochitinase 1 (Plant defensin) P86078 Belongs to the glycosyl hydrolase 20 family (Chitinase class I subfamily) Not found Capsicum annuum var. annuum (Red pepper) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale Submitted (JUL-2008) to UniProtKB "Belchi-Navarro S, Almagro L, Pedreno M.A." Not found DRAMP00305 NNFYSYNAFITAAKSFPGFGTTGDTAVRGPIQISYNYNYGPCGR 44 Endochitinase 1 (Plant defensin) P86081 Belongs to the glycosyl hydrolase 21 family (Chitinase class I subfamily) Not found Capsicum chinense (Scotch bonnet) (Bonnet pepper) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale Submitted (JUL-2008) to UniProtKB "Gomez Ros L.V, Almagro L, Ros Barcelo A, Pedreno M.A." Not found DRAMP00306 GPLQLSWNYNYGAAGK 16 Endochitinase 1 (Plant defensin) P85343 Belongs to the glycosyl hydrolase 22 family (Chitinase class I subfamily) Not found Ginkgo biloba (Ginkgo) (Maidenhair tree) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19157640 J Plant Physiol. 2009 May 15;166(8):831-843. "Uzal EN, Gmez-Ros LV, Hernndez JA, Pedre?o MA, Cuello J, Ros Barcel A." Analysis of the soluble cell wall proteome of gymnosperms. DRAMP00307 EQCGNQAGGXVPPNG 15 Endochitinase A1 (Plant defensin) P21225 Belongs to the glycosyl hydrolase 23 family (Chitinase class I subfamily) Not found Pisum sativum (Garden pea) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Induction: By infection with the fungal pathogen Ascochyta pisi." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale Planta 184:24-29(1991). "Vad K, Mikkelsen JD, Collinge DB." "Induction, purification and characterization of chitinase isolated from pea leaves inoculated with Ascochyta pisi." DRAMP00308 AIGFDGLNDPDIVAR 15 Endochitinase 1 (Plant defensin) P85337 Belongs to the glycosyl hydrolase 24 family (Chitinase class I subfamily) Not found Taxus baccata (English yew) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19157640 J Plant Physiol. 2009 May 15;166(8):831-843. "Uzal EN, Gmez-Ros LV, Hernndez JA, Pedre?o MA, Cuello J, Ros Barcel A." Analysis of the soluble cell wall proteome of gymnosperms. DRAMP00309 MTEQKPKPSCHNVMVGNYVPTASDRAANRTLGFGLVTNIINGGLDC 46 Endochitinase 2 (CHIT 2; Plant defensin) Q06014 Belongs to the glycosyl hydrolase 25 family (Chitinase class I subfamily) Not found Arachis hypogaea (Peanut) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense against chitin containing fungal and bacterial pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Induction: By glucan and Phytophthora megasperma elicitors." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1980004 Mol Gen Genet. 1990 Dec;224(3):469-476. "Herget T, Schell J, Schreier PH." Elicitor-specific induction of one member of the chitinase gene family in Arachis hypogaea. DRAMP00310 SAIWFWMTPQSPK 13 Endochitinase 2 (Plant defensin) P86079 Belongs to the glycosyl hydrolase 26 family (Chitinase class I subfamily) Not found Capsicum annuum var. annuum (Red pepper) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale Submitted (JUL-2008) to UniProtKB "Gomez Ros L.V, Almagro L, Ros Barcelo A, Pedreno M.A." Not found DRAMP00311 GPIQISYNYNYGPCGRYCGILGVSPGDNLDCGNQR 35 Endochitinase 2 (Plant defensin) P86082 Belongs to the glycosyl hydrolase 27 family (Chitinase class I subfamily) Not found Capsicum chinense (Scotch bonnet) (Bonnet pepper) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale Submitted (JUL-2008) to UniProtKB "Sabater Jara A.B, Almagro L, Pedreno M.A." Not found DRAMP00312 TAGFGVFTNIINGGLECGK 19 Endochitinase 2 (Plant defensin) P85338 Belongs to the glycosyl hydrolase 28 family (Chitinase class I subfamily) Not found Taxus baccata (English yew) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. PTM: Contians one disulfide bond (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19157640 J Plant Physiol. 2009 May 15;166(8):831-843. "Uzal EN, Gmez-Ros LV, Hernndez JA, Pedre?o MA, Cuello J, Ros Barcel A." Analysis of the soluble cell wall proteome of gymnosperms. DRAMP00313 MTPQGNKPSSHDVITGRWTPSDADRAAGRVSGFGVITNIINGGLDC 46 Endochitinase 3 (CHIT 3; Plant defensin) Q06015 Belongs to the glycosyl hydrolase 29 family (Chitinase class I subfamily) Not found Arachis hypogaea (Peanut) "Antimicrobial, Antibacterial, Antifungal" Transcript level Not found Not found None "Function: Defense against chitin containing fungal and bacterial pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Induction: Constitutively expressed at low levels." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 1980004 Mol Gen Genet. 1990 Dec;224(3):469-476. "Herget T, Schell J, Schreier PH." Elicitor-specific induction of one member of the chitinase gene family in Arachis hypogaea. DRAMP00314 MYDESTGYSSALK 13 Endochitinase 3 (Plant defensin) P85355 Belongs to the glycosyl hydrolase 30 family (Chitinase class I subfamily) Not found Taxus baccata (English yew) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19157640 J Plant Physiol. 2009 May 15;166(8):831-843. "Uzal EN, Gmez-Ros LV, Hernndez JA, Pedre?o MA, Cuello J, Ros Barcel A." Analysis of the soluble cell wall proteome of gymnosperms. DRAMP00315 MTPQGNKPSCHDVITNAWRPTATDSAAGRAPGYGVITNIINGGLDC 46 Endochitinase 4 (CHIT 4; Plant defensin) Q06016 Belongs to the glycosyl hydrolase 31 family (Chitinase class I subfamily) Not found Arachis hypogaea (Peanut) "Antimicrobial, Antibacterial, Antifungal" Transcript level Not found Not found None "Function: Defense against chitin containing fungal and bacterial pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Induction: By glucan elicitor, and to a lesser extent by yeast extract, Phytophthora megasperma elicitor, UV light and dilution." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 1980004 Mol Gen Genet. 1990 Dec;224(3):469-476. "Herget T, Schell J, Schreier PH." Elicitor-specific induction of one member of the chitinase gene family in Arachis hypogaea. DRAMP00316 MTAQGNKPSSHDVITGRWTPSAADRAAGRVSGFGVITNIINGGLDC 46 Endochitinase 1A (CHIT 1A; Plant defensin) Q06012 Belongs to the glycosyl hydrolase 32 family (Chitinase class I subfamily) Not found Arachis hypogaea (Peanut) "Antimicrobial, Antibacterial, Antifungal" Transcript level Not found Not found None "Function: Defense against chitin containing fungal and bacterial pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Induction: By yeast extract and dilution. Slight induction by glucan elicitor." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 1980004 Mol Gen Genet. 1990 Dec;224(3):469-476. "Herget T, Schell J, Schreier PH." Elicitor-specific induction of one member of the chitinase gene family in Arachis hypogaea. DRAMP00317 MTAQGNKPSSHDVITGRWTPSAADKAAGRVSGFGVITNIINGGLDC 46 Endochitinase 1B (CHIT 1B; Plant defensin) Q06013 Belongs to the glycosyl hydrolase 33 family (Chitinase class I subfamily) Not found Arachis hypogaea (Peanut) "Antimicrobial, Antibacterial, Antifungal" Transcript level Not found Not found None "Function: Defense against chitin containing fungal and bacterial pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Induction: By yeast extract and dilution. Slight induction by glucan elicitor." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 1980004 Mol Gen Genet. 1990 Dec;224(3):469-476. "Herget T, Schell J, Schreier PH." Elicitor-specific induction of one member of the chitinase gene family in Arachis hypogaea. DRAMP00318 EQCGRQAGGATCPNNLCCSQYGY 23 Endochitinase B (Plant defensin) P21227 Belongs to the glycosyl hydrolase 34 family (Chitinase class I subfamily) Not found Pisum sativum (Garden pea) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens. Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Induction: By infection with the fungal pathogen Ascochyta pisi." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding PubMed ID is not availbale Planta 184:24-29(1991). "Vad K, Mikkelsen JD, Collinge DB." "Induction, purification and characterization of chitinase isolated from pea leaves inoculated with Ascochyta pisi." DRAMP00319 ENCGRQAG 8 Endochitinase (Plant defensin) P86473 Belongs to the glycosyl hydrolase 35 family (Chitinase class I subfamily) Not found Actinidia chinensis (Kiwi) (Yangtao) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Defense against chitin containing fungal pathogens (By similarity). Catalytic activity: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Allergenic properties: Causes an allergic reaction in human. Domian: Contains 1 chitin-binding type-1 domain." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet IgE 1553642 Tidsskr Nor Laegeforen. 1992 Jan 10;112(1):38-42. Rygnestad T. Suicide in Norway. Changes in the 20th century with special emphasis on the development during the last 20 years. DRAMP00324 GIFTFEDESTSTVAPAKLYK 20 Protein PR-L1 (Plant defensin) P83363 Belongs to the BetVI family Not found Lupinus luteus (European yellow lupin) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Pathogenesis-related protein. May have antifungal or antibacterial activity. Induction: By heavy metal ions." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale J. Plant Physiol. 1999;154:703-708. "Przymusinski R, Gwozdz E.A." Heavy metal-induced polypeptides in lupin roots are similar to pathogenesis-related proteins. DRAMP00325 SVFAFENEQSSTIAPARLYK 20 Protein PR-L2 (Plant defensin) P83364 Belongs to the BetVI family Not found Lupinus luteus (European yellow lupin) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Pathogenesis-related protein. May have antifungal or antibacterial activity. Induction: By heavy metal ions." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale J. Plant Physiol. 1999;154:703-708. "Przymusinski R, Gwozdz E.A." Heavy metal-induced polypeptides in lupin roots are similar to pathogenesis-related proteins. DRAMP00326 GIFTFEDESTTTVAPAKLYK 20 Protein PR-L3 (Plant defensin) P83365 Belongs to the BetVI family Not found Lupinus luteus (European yellow lupin) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Pathogenesis-related protein. May have antifungal or antibacterial activity. Induction: By heavy metal ions." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale J. Plant Physiol. 1999;154:703-708. "Przymusinski R, Gwozdz E.A." Heavy metal-induced polypeptides in lupin roots are similar to pathogenesis-related proteins. DRAMP00327 SVFAFQDESTSTIAQARLFI 20 Protein PR-L4 (Plant defensin) P83366 Belongs to the BetVI family Not found Lupinus luteus (European yellow lupin) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Pathogenesis-related protein. May have antifungal or antibacterial activity. Induction: By heavy metal ions." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale J. Plant Physiol. 1999;154:703-708. "Przymusinski R, Gwozdz E.A." Heavy metal-induced polypeptides in lupin roots are similar to pathogenesis-related proteins. DRAMP00328 SIFAFQDESPSAIAQAKLFK 20 Protein PR-L5 (Plant defensin) P83367 Belongs to the BetVI family Not found Lupinus luteus (European yellow lupin) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Pathogenesis-related protein. May have antifungal or antibacterial activity. Induction: By heavy metal ions." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale J. Plant Physiol. 1999;154:703-708. "Przymusinski R, Gwozdz E.A." Heavy metal-induced polypeptides in lupin roots are similar to pathogenesis-related proteins. DRAMP00329 GVFTFEDESTSTVAPAKLYK 20 Protein PR-L6 (Plant defensin) P83368 Belongs to the BetVI family Not found Lupinus luteus (European yellow lupin) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Pathogenesis-related protein. May have antifungal or antibacterial activity. Induction: By heavy metal ions." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not availbale J. Plant Physiol. 1999;154:703-708. "Przymusinski R, Gwozdz E.A." Heavy metal-induced polypeptides in lupin roots are similar to pathogenesis-related proteins. DRAMP00339 GADFQECMKEHSQKQHQHQG 20 Alpha-basrubrin (Fragment; Plants) P83186 Not found Not found Basella alba (Malabar spinach) (Basella rubra) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Function: Inhibits HIV-1 reverse transcriptase and cell-free translation. "Fungi: Botrytis cinerea, Mycosphaerella arachidicola, Fusarium oxysporum." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11688973 Biochem Biophys Res Commun. 2001 Nov 9;288(4):765-770. "Wang H, Ng T.B." Novel antifungal peptides from ceylon spinach seeds. DRAMP00340 KIMAKPSKFYEQLRGR 16 Beta-basrubin (Plants) P83187 Not found Not found Basella alba (Malabar spinach) (Basella rubra) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Function: Possesses antifungal activity. Inhibits HIV-1 reverse transcriptase and cell-free translation. "Fungi: Botrytis cinerea, Mycosphaerella arachidicola, Fusarium oxysporum." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11688973 Biochem Biophys Res Commun. 2001 Nov 9;288(4):765-770. "Wang H, Ng T.B." Novel antifungal peptides from ceylon spinach seeds. DRAMP00341 ANTAFVSSAHNTQKIPAGAPFNRNLRAMLADLRQNAAFAG 40 "Antifungal protein ginkbilobin-1 (Ginkbilobin, GNL; Plants)" P83171 Not found GNK1 Ginkgo biloba (Ginkgo) (Maidenhair tree) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Not found Not found None Function: Also inhibits HIV-1 reverse transcriptase and proliferation of murine splenocytes. "Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli.##Fuungi: Botrytis cinerea, Mycosphaerella arachidicola, Fusarium oxysporum, Rhizoctonia solani, Coprinus comatus," No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11118300 Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411. "Wang H, Ng T.B." "Ginkbilobin, a novel antifungal protein from Ginkgo biloba seeds with sequence similarity to embryo-abundant protein." DRAMP00342 ATITVVNRCSYTVWPGALPGGGVRLDPGQRWALNMPAGTAGAAV 44 Antifungal protein R (Plant defensin) P33044 Not found Not found Hordeum vulgare (Barley) "Antimicrobial, Antifungal" Protein level Not found Not found None Function: Has antifungal activity. Inhibits the growth of Trichoderma viridae and Candida albicans. "Fungi: Trichoderma viridae, Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1936240 FEBS Lett. 1991 Oct 7;291(1):127-131. "Hejgaard J, Jacobsen S, Svendsen I." Two antifungal thaumatin-like proteins from barley grain. DRAMP00343 ATFTVINKCQYTVWAAAVPAGGGQKLDAGQTWSIXXP 37 Antifungal protein S (Plant defensin) P33045 Not found Not found Hordeum vulgare (Barley) "Antimicrobial, Antifungal" Protein level Not found Not found None Function: Has antifungal activity. Inhibits the growth of Trichoderma viridae and Candida albicans. "Fungi: Trichoderma viridae, Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1936240 FEBS Lett. 1991 Oct 7;291(1):127-131. "Hejgaard J, Jacobsen S, Svendsen I." Two antifungal thaumatin-like proteins from barley grain. DRAMP00346 AITCGQVSSALGPCAAYAKGSGTSPSAGCCSGVKRLAGLARSTADKQATCRCLKSVAGAYNAGRAAGIPSRCGVSVPYTISASVDCSKIH 90 Non-specific lipid-transfer protein Cw18 (LTP Cw-18; PKG2316; Plants) Q43871 Belongs to the plant LTP family CW18 Hordeum vulgare (Barley) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. Tissue specificity: Highly expressed in leaves and coleoptiles. No expression in roots. Induction: By NaCl, abscisic acid and inoculation with the fungal pathogen E. graminis. PTM: Contains four disulfide bonds 4-52; 14-29; 30-72; 50-86." "Fungi: Fusarim solani (EC50=3-2010-6 M), Pseudomonas solanacearum (EC50=3-610-7 M), Pythium aphanidermatum, Clavibacter michiganensis subsp. Sepedonicus (EC50=l-310-7 M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding 8420795##8281190 FEBS Lett. 1993 Jan 25;316(2):119-122.##Plant J. 1993 Dec;4(6):983-991. "Molina A, Segura A, Garca-Olmedo F.##Molina A, Garc?a-Olmedo F." Lipid transfer proteins (nsLTPs) from barley and maize leaves are potent inhibitors of bacterial and fungal plant pathogens.##Developmental and pathogen-induced expression of three barley genes encoding lipid transfer proteins. DRAMP00347 AISCGQVSSALSPCISYARGNGAKPPVACCSGVKRLAGAAQSTADKQAACRCLKSLATSIKGINMGKVSGVPGKCGVSVPFPISMSTDCNKVH 93 Non-specific lipid-transfer protein 3 (LTP 3; CW-19; CW-20; Plants) Q43766 Belongs to the plant LTP family LTP3 Hordeum vulgare (Barley) "Antimicrobial, Antibacterial, Antifungal" Homology Not found Not found None "Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. PTM: Contains four disulfide bonds (By similarity)." "Fungi: Fusarim solani (EC50=3-2010-6 M), Pseudomonas solanacearum (EC50=3-610-7 M), Pythium aphanidermatum, Clavibacter michiganensis subsp. Sepedonicus (EC50=l-310-7 M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding 8420795##8281190 FEBS Lett. 1993 Jan 25;316(2):119-122.##Plant J. 1993 Dec;4(6):983-991. "Molina A, Segura A, Garca-Olmedo F.##Molina A, Garc?a-Olmedo F." Lipid transfer proteins (nsLTPs) from barley and maize leaves are potent inhibitors of bacterial and fungal plant pathogens.##Developmental and pathogen-induced expression of three barley genes encoding lipid transfer proteins. DRAMP00348 AISCGQVSSALSPCISYARGNGAKPPAACCSGVKRLAGAAQSTADKQAACKCIKSAAGGLNAGKAAGIPSMCGVSVPYAISASVDCSKIR 90 Non-specific lipid-transfer protein 4.1 (LTP 4.1; CW-21; Plants) Q43767 Belongs to the plant LTP family LTP4.1 Hordeum vulgare (Barley) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. PTM: Contains four disulfide bonds 4-52; 14-29; 30-72; 50-86." "Fungi: Fusarim solani (EC50=3-2010-6 M), Pseudomonas solanacearum (EC50=3-610-7 M), Pythium aphanidermatum, Clavibacter michiganensis subsp. Sepedonicus (EC50=l-310-7 M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding 8420795##8281190 FEBS Lett. 1993 Jan 25;316(2):119-122.##Plant J. 1993 Dec;4(6):983-991. "Molina A, Segura A, Garca-Olmedo F.##Molina A, Garc?a-Olmedo F." Lipid transfer proteins (nsLTPs) from barley and maize leaves are potent inhibitors of bacterial and fungal plant pathogens.##Developmental and pathogen-induced expression of three barley genes encoding lipid transfer proteins. DRAMP00360 ISCQDVKQSLAPCLPYVTGRAPKPA 25 Non-specific lipid-transfer protein 1 (LTP 1; Plants) P86527 Belongs to the plant LTP family Not found Nigella sativa (Black cumin) "Antimicrobial, Antifungal" Protein level Not found Not found None Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. Fungi: Fusarium oxysporum and Phytophthora infestans. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding 19621049 Bioorg Khim. 2009 May-Jun;35(3):344-349. "Oshchepkova IuI, Veshkurova ON, Rogozhin EA, Musoliamov AKh, Smirnov AN, Odintsova TI, Egorov TsA, Grishin EV, Salikhov ShI." Isolation of the lipid-transporting protein Ns-LTP1 from seeds of the garden fennel flower (Nigella sativa). DRAMP00361 ITCPQVTQSLAPCVPYLISG 20 Non-specific lipid-transfer protein (LTP; Harmalin; Plants) B3EWH4 Belongs to the plant LTP family Not found Peganum harmala (Syrian rue) (Harmal peganum) "Antimicrobial, Antifungal, Antiviral, Anti-cancer" Protein level Not found Not found None "Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. Inhibits cell proliferation of cervical carcinoma cell line HeLa (IC50=2.74 ?M), gastric carcinoma cell line MGC-7 (IC50=3.13 ?M), esophageal carcinoma cell line Eca-109 (IC50=0.7 ?M) and melanoma B16 cells (IC50=1.47 ?M). Has antifungal activity. Induces caspase-dependent apoptosis in cell line Eca-109. Demonstrates inhibitory effect on HIV-1 reverse transcriptase (IC50=1.26 ?M). Biophysicochemical properties: pH dependence (Stable between pH 4 and 10); Temperature dependence (Thermostable. Retains antifungal activity between 4 degrees Celsius and 60 degrees Celsius. Activity reduced after 30 min at 80 degrees Celsius)." "Fungi: Penicillium digitatum (IC50=37.5 ?M), Alternaria alternata (IC50=1.5 ?M), Rhizopus stolonifer (IC50=8.44 ?M) and Magnaporthe grisea (IC50=12.19 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding PubMed ID is not available Submitted (MAR-2012) to UniProtKB "Ma XJ, Liu DL, Tang HS, Wang Y, Sun SR." "Purification and characterization of a novel protein from Peganum harmala seeds with antifungal, antiproliferation and anti-HIV-1 reverse transcriptase activities." DRAMP00369 ITCGLVASKLAPCIGYLQGAPGPSAACCGGIKSLNSAAASPADRKTACTCLKSAATSIKGINYGKAASLPRQCGVSVPYAISPNTNCNAIH 91 IWF1 (Bv-LTP1; Plant defensin) Q43748 Belongs to the plant LTP family IWF1' Beta vulgaris (Sugar beet) "Antimicrobial, Antifungal" Homology Not found Not found None Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. Also has fungicide activity. Fungi: Cercospora beticola. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding 8790287 Plant Mol Biol. 1996 Jun;31(3):539-552. "Nielsen KK, Nielsen JE, Madrid SM, Mikkelsen JD." New antifungal proteins from sugar beet (Beta vulgaris L.) showing homology to non-specific lipid transfer proteins. DRAMP00370 ITCGQVTSQVAGCLSYLQRGGAPAPXXXXGIRNLXXMA 38 Antifungal protein 5 (CW-5; Plants) P83139 Belongs to the plant LTP family Not found Malva parviflora (Little mallow) (Cheeseweed mallow) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Possesses potent antifungal activity against F. graminearum but not P. infestans. Miscellaneous: Under low salt conditions, possesses potent antifungal activity but activity is drastically reduced under high salt conditions." Fungi: Fusarium graminearum. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11302747 Biochem Biophys Res Commun. 2001 Apr 20;282(5):1224-1228. "Wang X, Bunkers GJ, Walters MR, Thoma RS." Purification and characterization of three antifungal proteins from cheeseweed (Malva parviflora). DRAMP00372 AVSCGDVTSSIAPCLSYVMGRESSPSSSCCSGVRTLNGKASSSADRRTACSCLKNMASSFRNLNMGNAASIPSKCGVSVAFPISTSVDCSKIN 93 Non-specific lipid-transfer protein 3 (Os-LTP3) "Q2QYL3, Q42976, Q8GZV1" Belongs to the plant LTP family LTP110-A Oryza sativa Japonica Group "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. May possess an antifungal activity and protect the plant against pathogens. PTM: Problely contains four disulfide bonds 4-52; 14-29; 30-75; 50-89. " "Pyricularia oryzae, Xanthomonas oryzae." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14659081 J Biochem Mol Biol. 2003 Nov 30;36(6):603-607. "Ge X, Chen J, Li N, Lin Y, Sun C, Cao K." Resistance Function: of rice lipid transfer protein LTP110. DRAMP00373 ALSCGTVNSNLAACIGYLTQNAPLARGCCTGVTNLNNMAXTTP 43 Seed non-specific lipid transfer protein-like (ns-LTP; Plants) P29420 Belongs to the plant LTP family Not found Raphanus sativus (Radish) "Antimicrobial, Antifungal" Protein level Not found Not found None Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. This isoform inhibits the hyphal growth of several fungi in vitro. "Fungi: Alternaria brassicola (MUCL 20297) (IC50=48 ?g/mL), Ascochyta pisi (MUCL 20164) (IC50=41 ?g/mL), Botrytis cinerea (MUCL 30158) (IC50=45 ?g/mL), Colletotrichum lindemuthianum (MUCL 9577) (IC50=25 ?g/mL), Fusarium culmorum (IMI 180420) (IC50=20 ?g/mL), Fusarium oxysporum f. sp. lycopersici (MUCL 909) (IC50=54 ?g/mL), Fusarium oxysporum f. sp. pisi (IMI 236441) (IC50=58 ?g/mL), Nectria haematococca (Collection Van Etten 26022) (IC50=100 ?g/mL), Phoma betae (MUCL 9916) (IC50=18 ?g/mL), Pyricularia oryzae (MUCL 30166) (IC50=10 ?g/mL), Trichoderma hamatum (MUCL 29736) (IC50=30 ?g/mL), Verticillium dahliae (MUCL 6963) (IC50=7 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding 16653017 Plant Physiol. 1992 Oct;100(2):1055-1058. "Terras FR, Goderis IJ, Van Leuven F, Vanderleyden J, Cammue BP, Broekaert WF." In vitro antifungal activity of a radish (Raphanus sativus L.) seed protein homologous to non-specific lipid transfer proteins. DRAMP00375 PAGPFRIPPRXRXEFQ 16 Antifungal protein 1 small subunit (CW-1; Plants) P83140 Not found Not found Malva parviflora (Little mallow) (Cheeseweed mallow) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Possesses very potent antifungal activity against F. graminearum. Subunit structure: Heterodimer of a large and a small subunit. Miscellaneous: Antimicrobial activity is not affected by salt concentration." Fungi:##At low salt condition: Fusarium graminearum (IC50=2.5 ppm).##At high salt condition: Fusarium graminearum (IC50=10 ppm). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11118343 Biochem Biophys Res Commun. 2000 Dec 20;279(2):669-673. "Wang X, Bunkers GJ." Potent heterologous antifungal proteins from cheeseweed (Malva parviflora). DRAMP00376 VAGPFRIPPLRREFQ 15 Antifungal protein 1 large subunit (CW-1; Plants) P83141 Not found Not found Malva parviflora (Little mallow) (Cheeseweed mallow) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity against P. infestans but not F. graminearum. Subunit structure: Heterodimer of a large and a small subunit. Miscellaneous: Antimicrobial activity is not affected by salt concentration." Fungi: Phytophthora infestans. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11118343 Biochem Biophys Res Commun. 2000 Dec 20;279(2):669-673. "Wang X, Bunkers GJ." Potent heterologous antifungal proteins from cheeseweed (Malva parviflora). DRAMP00377 SDYSRKRDPPQKYEEE 16 Antifungal protein 2 small subunit (CW-2; Plants) P83142 Not found Not found Malva parviflora (Little mallow) (Cheeseweed mallow) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity against P. infestans but not F. graminearum. Subunit structure: Heterodimer of a large and a small subunit. Miscellaneous: Antimicrobial activity is not affected by salt concentration." Fungi: Phytophthora infestans. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11118343 Biochem Biophys Res Commun. 2000 Dec 20;279(2):669-673. "Wang X, Bunkers GJ." Potent heterologous antifungal proteins from cheeseweed (Malva parviflora). DRAMP00378 PEDPQRRYQEXQREXRXQQE 20 Antifungal protein 2 large subunit (CW-2; Plants) P83143 Not found Not found Malva parviflora (Little mallow) (Cheeseweed mallow) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity against P. infestans but not F. graminearum. Subunit structure: Heterodimer of a large and a small subunit. Miscellaneous: Antimicrobial activity is not affected by salt concentration." Fungi: Phytophthora infestans. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11118343 Biochem Biophys Res Commun. 2000 Dec 20;279(2):669-673. "Wang X, Bunkers GJ." Potent heterologous antifungal proteins from cheeseweed (Malva parviflora). DRAMP00379 PEDPQRRYQEEQRRE 15 Antifungal protein 3 (CW-3; Plants) P83137 Not found Not found Malva parviflora (Little mallow) (Cheeseweed mallow) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity. Miscellaneous: Antimicrobial activity is not affected by salt concentration." Fungi: Phytophthora infestans. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11302747 Biochem Biophys Res Commun. 2001 Apr 20;282(5):1224-1228. "Wang X, Bunkers GJ, Walters MR, Thoma RS." Purification and characterization of three antifungal proteins from cheeseweed (Malva parviflora). DRAMP00380 DRQIDMEEQQLEKLNKQDRXPGLRYAAKQQMXTXRMG 37 Antifungal protein 4 (CW-4; Plants) P83138 Not found Not found Malva parviflora (Little mallow) (Cheeseweed mallow) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity. Miscellaneous: Antimicrobial activity is not affected by salt concentration. Biophysicochemical properties: Temperature dependence (Thermostable). Still active after heating at 100 degrees Celsius for 20 minutes." Fungi: Phytophthora infestans. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11302747 Biochem Biophys Res Commun. 2001 Apr 20;282(5):1224-1228. "Wang X, Bunkers GJ, Walters MR, Thoma RS." Purification and characterization of three antifungal proteins from cheeseweed (Malva parviflora). DRAMP00381 SGECNMYGRCPPGYCCSKFGYCGGVRAYCG 30 IWF4 (Plants) No entry found Not found Not found Beta vulgaris (Sugar beet) "Antimicrobial, Antifungal" Not found Not found Not found None "Tissue specificity: IWF4 mRNA is expressed in the aerial parts of the plant only, with a constitutive expression in young and mature leaves and in young flowers." Fungi: Cercospora beticola (IC50<2 ?g/mL). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Chitin-binding 9008390 Plant Physiol. 1997 Jan;113(1):83-91. "Nielsen KK, Nielsen JE, Madrid SM, Mikkelsen JD." Characterization of a new antifungal chitin-binding peptide from sugar beet leaves. DRAMP00382 TFPKCAPTRPPGPKPCDINNFKSKFWHIWRA 31 Datucin (Glycopeptide; Plants) No entry found Not found Not found Datura stramonium "Antimicrobial, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23193597 Biopolymers 2012; 98(4):332-337. Mandal SM. A Novel Hydroxyproline Rich Glycopeptide from Pericarp of Datura stramonium: Proficiently Eradicate the Biofilm of Antifungals Resistant Candida albicans. DRAMP00383 AKCIKNGKGCREDQGPPFCCSGFCYRQVGWARGYCKNR 38 Antimicrobial peptide 1 (Mc-AMP1; knottin-type peptide; Plant defensin) O81338 Belongs to the AMP family Not found Mesembryanthemum crystallinum (Common ice plant) (Cryophytum crystallinum) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Homology Bridge Not found None "Function: Possesses antifungal and antibacterial activity. Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. PTM: Contains three disulfide bonds 3-20; 10-24; 18-35." "Gram-positive bacteria: Bacillus megaterium (IC50=2 ?g/mL), Sarcina lutea (IC50=50 ?g/mL).##Fungi: Alternaria brassicola (IC50=6 ?g/mL), Ascochyta pisi (IC50=6 ?g/mL), Botrytis cinerea (IC50=2 ?g/mL), Cercospora beticola (IC50=2 ?g/mL), Colletotrichum lindemuthianum (IC50=1 ?g/mL), Fusarium culmorum (IC50=3 ?g/mL), Fusarium oxysporum f. sp. Pisi (IC50=5 ?g/mL), Fusarium oxysporum f. sp. Lycopersici (IC50=10 ?g/mL), Nectria haematococca (IC50=0.5 ?g/mL), Phoma betae (IC50=6 ?g/mL), Pyrenophora tritici-repentis (IC50=20 ?g/mL), Pyricularia oryzae (IC50=0.5 ?g/mL), Rhizoctonia solani (IC50=15 ?g/mL), Verticiliium dahliae (IC50=0.5 ?g/mL), Venturia inaequalis (IC50=1 ?g/mL)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases. "Michalowski C.B, Bohnert H.J." Antimicrobial peptide 1 from the common ice plant. DRAMP00386 AISCGQVSSAIGPCLSYARGQGSAPSAGCC 30 EcLTP (E. crus-galli lipid transfer protein; Plants) No entry found Not found Not found Echinochloa crusgalli L. (seeds of weed cereal barnyard grass) "Antimicrobial, Antifungal" Not found Not found Not found None Function: Possesses antifungal activity. Fungi: Phytophthora infestans (IC50=6 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22940285 Peptides. 2012 Nov;38(1):33-40. "Rogozhin EA, Ryazantsev DY, Grishin EV, Egorov TA, Zavriev SK." Defense peptides from barnyard grass (Echinochloa crusgalli L.) seeds. DRAMP00387 GSGRGSCRSQCMRRHEDEPWRVQECVSQCRRRRGGGD 37 Antimicrobial peptide 1 (EcAMP1; hairpin-like peptides; Plants) P86698 Not found Not found Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli) "Antimicrobial, Antifungal" Protein level Alpha helix (3 helices; 20 residues) The peptide adopts a disulfide-stabilized alpha-helical hairpin structure in aqueous solution and thus represents a novel fold among naturally occurring antimicrobial peptides. 2L2R resolved by NMR. "Function: EcAMP1 can inhibit growth of several fungal phytopathogens. Does not destroy spores but rather inhibits hyphal growth during germination. Does not affect spore germination in A. niger, C. graminicola, D. maydis and T. album. Does not inhibit trypsin. Confocal microscopy revealed intensive EcAMP1 binding to the surface of fungal conidia followed by internalization and accumulation in the cytoplasm without disturbance of membrane integrity. Tissue specificity: Seed." "Fungi: Alternaria alternata (EC50=16.02.3 ?M), A. solani (EC50=14.02.1 ?M), Aspergillus niger (EC50>32 ?M), Bipolaris sorokiniana (EC50=18.22.7 ?M), Colletotrichum graminicola (EC50>10 ?M), Diplodia maydis (EC50>10 ?M), Fusarium graminearum (EC50=4.51.4 ?M), Fusarium oxysporum (EC50=8.51.6 ?M), F. solani (EC50=4.01.2 ?M), F. verticillioides (EC50=8.12.3 ?M), Phoma betae (EC50=6.01.5 ?M), Phytophthora infestans (EC50=16.32.5 ?M), Pythium debaryanum (EC50=12.01.7 ?M), P. ultimum (EC50=14.42.1 ?M), Tritirachium album (EC50>32 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22940285##21561864 Peptides. 2012 Nov;38(1):33-40.##J Biol Chem. 2011 Jul 15;286(28):25145-25153. "Rogozhin EA, Ryazantsev DY, Grishin EV, Egorov TA, Zavriev SK.##Nolde SB, Vassilevski AA, Rogozhin EA, Barinov NA, Balashova TA, Samsonova OV, Baranov YV, Feofanov AV, Egorov TA, Arseniev AS, Grishin EV." Defense peptides from barnyard grass (Echinochloa crusgalli L.) seeds.##Disulfide-stabilized helical hairpin structure and activity of a novel antifungal peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli). DRAMP00388 DRCSQQCQHHRDPDRKQQCMRECRRHQGRSD 31 Antimicrobial peptide 2 (EcAMP2; Plants) B3EWR4 Not found Not found Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: EcAMP2 inhibits spore germination of P. infestans with an IC50 of 24 ?M but have no antibacterial activity. PTM: Contains two disulfide bonds (By similarity)." Fungi: Phytophthora infestans (IC50=24 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22940285 Peptides. 2012 Nov;38(1):33-40. "Rogozhin EA, Ryazantsev DY, Grishin EV, Egorov TA, Zavriev SK." Defense peptides from barnyard grass (Echinochloa crusgalli L.) seeds. DRAMP00389 DRCSQQCQHHRDPDRKQQCMRECRRH 26 EcAMP2.1 (truncated EcAMP2 without five C-terminal residues) B3EWR4 Not found Not found Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: EcAMP2.1 inhibits spore germination of P. infestans with an IC50 of 24 ?M but have no antibacterial activity. PTM: Contains two disulfide bonds (By similarity)." Fungi: Phytophthora infestans (IC50=24 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22940285 Peptides. 2012 Nov;38(1):33-40. "Rogozhin EA, Ryazantsev DY, Grishin EV, Egorov TA, Zavriev SK." Defense peptides from barnyard grass (Echinochloa crusgalli L.) seeds. DRAMP00390 ANKCIIDCMKVKTTCGDECKGAGFKTGGCALPPDIMKCCHNC 42 Antimicrobial peptide 3 (ToAMP3; Cys-rich; Plant defensin) B3EWQ3 Not found Not found Taraxacum officinale (Common dandelion) (Leontodon taraxacum) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity. Also active against bacterial species P. syringae, B. subtilis and X. campestris. Tissue specificity: Expressed in flowers but not in leaves, seeds or roots (at protein level)." Fungi: Aspergillus niger (IC50=1.2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22640720 Peptides. 2012 Aug;36(2):266-271. "Astafieva AA, Rogozhin EA, Odintsova TI, Khadeeva NV, Grishin EV, Egorov TsA." Discovery of novel antimicrobial peptides with unusual cysteine motifs in dandelion Taraxacum officinale Wigg. flowers. DRAMP00391 GGKCTVDWGGQGGGRRLPSPLFCCYKPTRICYLNQETCETETCP 44 Antimicrobial peptide 2 (ToAMP2; Cys-rich; Plant defensin) B3EWQ2 Not found Not found Taraxacum officinale (Common dandelion) (Leontodon taraxacum) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity. Also active against bacterial species P. syringae, B. subtilis and X. campestris. Tissue specificity: Expressed in flowers but not in leaves, seeds or roots (at protein level)." "Fungi: Botrytis cinerea (IC50=5.2 ?M), Aspergillus niger (IC50=2.6 ?M), Bipolaris sorokiniana (IC50=5.2 ?M), Pythium debaryanum (IC50=2.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22640720 Peptides. 2012 Aug;36(2):266-271. "Astafieva AA, Rogozhin EA, Odintsova TI, Khadeeva NV, Grishin EV, Egorov TsA." Discovery of novel antimicrobial peptides with unusual cysteine motifs in dandelion Taraxacum officinale Wigg. flowers. DRAMP00392 VAKCTEESGGKYFVFCCYKPTRICYMNEQKCESTCIGK 38 Antimicrobial peptide 1 (ToAMP1; Cys-rich; Plant defensin) B3EWQ1 Not found Not found Taraxacum officinale (Common dandelion) (Leontodon taraxacum) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity. Also active against bacterial species P. syringae, B. subtilis and X. campestris. Tissue specificity: Expressed in flowers but not in leaves, seeds or roots (at protein level)." "Fungi: Botrytis cinerea (IC50=5.8 ?M), Aspergillus niger (IC50=5.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22640720 Peptides. 2012 Aug;36(2):266-271. "Astafieva AA, Rogozhin EA, Odintsova TI, Khadeeva NV, Grishin EV, Egorov TsA." Discovery of novel antimicrobial peptides with unusual cysteine motifs in dandelion Taraxacum officinale Wigg. flowers. DRAMP00393 IQCGESCVWIPCISSAWGCSCKNKICSS 28 Hedyotide B2 (hB2; Uncyclotides; Plants) No entry found Not found Not found Hedyotis biflora (aerial tissues) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Not found Not found Not found None Function: Possesses antifungal activity. "Gram-negative bacterium: Escherichia coli (MIC>80 ?M);##Gram-positive bacteria: Streptococcus salivarius(MIC>80 ?M), Staphylococcus epidermidis (MIC>80 ?M), Streptococcus aureus (MIC>80 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21979955 J Biol Chem. 2011 Dec 30;286(52):44833-44844. "Nguyen GK, Zhang S, Wang W, Wong CT, Nguyen NT, Tam JP." Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. DRAMP00396 NLCERASLTWTGNCGNTGHCDTQCRNWESAKHGACHKRGNWKCFCYFDC 49 "Ct-AMP1 (CtAMP1, C. ternatea-antimicrobial peptide 1; Plant defensin)" No entry found Not found Not found Clitoria ternatea "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database "Gram-positive bacterium: Bacillus subtilis (IC50=15 ?g/mL).##Medium A: Botrytis cinerea (IC50=20 ?g/ml), Cladosporium sphaerospermum (IC50=6 ?g/ml), Fusarium culmorum (IC50=10 ?g/ml), Leptosphaeria maculans (IC50=6 ?g/ml), Penicillium digitatum (IC50=20 ?g/ml), Trichoderma viride (IC50>100 ?g/ml), Septoria tritiei (IC50=2 ?g/ml), Verticilium albo-atrum (IC50=2 ?g/ml). NOTE: Medium B = 1/2 strength potato dextrose broth.##Medium B: Botrytis cinerea (IC50>100 ?g/ml), Cladosporium sphaerospermum (IC50=100 ?g/ml), Fusarium culmorum (IC50=50 ?g/ml), Leptosphaeria maculans (IC50=20 ?g/ml), Penicillium digitatum (IC50=80 ?g/ml), Trichoderma viride (IC50>100 ?g/ml), Septoria tritiei (IC50=80 ?g/ml), Verticilium albo-atrum (IC50>100 ?g/ml).##NOTE: Medium B = Medium A supplemented with 1 mM CaCl2 and 50 mM KCI." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7628617 FEBS Lett. 1995 Jul 17;368(2):257-262. "Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Rees SB, Broekaert WF." "Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae." DRAMP00397 KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKPPAHRCICYYEC 50 Defensin D1 (Ns-D1; Plant defensin) P86972 Belongs to the DEFL family Not found Nigella sativa (Black cumin) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Function: Antimicrobial peptide active against fungi, Gram-positive and Gram-negative bacteria. Has no effect on spore germination. Destroys spores in germinated conidia by disruption of cell walls and membranes in A. niger and B. sorokiniana. Causes vacuolization of germinated macro- and microconidia in F. oxysporum, F. graminearum and F. culmorum. Strongly inhibits growth of P. infestans on potato tubers above concentrations of 13.6 ?g/ml. PTM: Contains four disulfide bonds." "Fungi: Aspergillus niger (IC50=3.5 ?g/ml), Bipolaris sorokiniana (IC50=3.0 ?g/ml), Fusarium oxysporum (IC50=9.5 ?g/ml), Fusarium graminearum (IC50=6.9 ?g/ml), Fusarium culmorum (IC50=6.9 ?g/ml) and Botrytis cinerea (IC50=27.4 ?g/ml).##Gram-positive bacteria: Clavibacter michiganensis (1.4 cm) and Bacillus subtilis (1.3 cm);##Gram-negative bacteria: Pseudomonas syringae (0.9 cm), Erwinia carotovora (0.7 cm) and Escherichia coli (1.2 cm).##NOTE: Inhibition zone; Defensin concentration (11 ?g in 50 ??l)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21144761 Plant Physiol Biochem. 2011 Feb;49(2):131-137. "Rogozhin EA, Oshchepkova YI, Odintsova TI, Khadeeva NV, Veshkurova ON, Egorov TA, Grishin EV, Salikhov SI." Novel antifungal defensins from Nigella sativa L. seeds. DRAMP00398 KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKLPAHRCICYYEC 50 Defensin D2 (Ns-D2; Plant defensin) P86973 Belongs to the DEFL family Not found Nigella sativa (Black cumin) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Function: Antimicrobial peptide active against fungi, Gram-positive and Gram-negative bacteria. Has no effect on spore germination. Destroys spores in germinated conidia by disruption of cell walls and membranes in Aspergillus niger and B.sorokiniana. Causes vacuolization of germinated macro- and microconidia in Fusarium oxysporum, F.graminearum and F.culmorum. Strongly inhibits growth of P.infestans on potato tubers above concentrations of 3.4 ?g/ml. PTM: Contains four disulfide bonds." "Fungi: Aspergillus niger (IC50=3.5 ?g/ml), Bipolaris sorokiniana (IC50=1.8 ?g/ml), Fusarium oxysporum (IC50=5.3 ?g/ml), Fusarium graminearum (IC50=6.9 ?g/ml), Fusarium culmorum (IC50=6.9 ?g/ml) and Botrytis cinerea (IC50=13.7 ?g/ml).##Gram-positive bacteria: Clavibacter michiganensis (1.5 cm) and Bacillus subtilis (1.3 cm);##Gram-negative bacteria: Pseudomonas syringae (1.3 cm), Erwinia carotovora (0.7 cm) and Escherichia coli (1.4 cm).##NOTE: Inhibition zone; Defensin concentration (11 ?g in 50 ??l)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21144761 Plant Physiol Biochem. 2011 Feb;49(2):131-137. "Rogozhin EA, Oshchepkova YI, Odintsova TI, Khadeeva NV, Veshkurova ON, Egorov TA, Grishin EV, Salikhov SI." Novel antifungal defensins from Nigella sativa L. seeds. DRAMP00399 NTCEHLADTYRGVCFTNASCDDHCKNKAHLISGTCHDWKCFCTQNC 46 Defensin-like protein 39 (Disease resistance response protein 39; Plant defensin) Q01784 Belongs to the DEFL family PI39 Pisum sativum (Garden pea) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Possesses antifungal activity (By similarity). Tissue specificity: Pods. Induction: Upon contact with the plant pathogen fungus Fusarium solani. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1799696 Mol Plant Microbe Interact. 1991 Jul-Aug;4(4):324-331. "Chiang CC, Hadwiger LA." The Fusarium solani-induced expression of a pea gene family encoding high cysteine content proteins. DRAMP00400 NLCERASLTWTGNCGNTGHCDTQCRNWESAKHGACHKRGNWKCFCYFNC 49 "Defensin-like protein 1 (Defensin AMP1, CtAMP1; Plant defensin)" Q7M1F2 Belongs to the DEFL family Not found Clitoria ternatea (Butterfly pea) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Possesses antimicrobial activity sensitive to inorganic cations. Binds specifically to the fungal plasma membrane. Has no inhibitory effect on insect gut alpha-amylase. PTM: Contains four disulfide bonds (By similarity)." "Fungi: Botrytis cinerea (IC50=20 ?g/ml), Cladosporium sphaerospermum (IC50=6 ?g/ml), Fusarium culmorum (IC50=10 ?g/ml), Leptosphaeria maculans (IC50=6 ?g/ml), Penicillium digitatum (IC50=20 ?g/ml), Trichoderma viride (IC50>100 ?g/ml), Septoria tritiei (IC50=2 ?g/ml), Verticilium albo-atrum (IC50=2 ?g/ml), Neurospora crassa (IC50<0.3 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet fungal plasma membrane 7628617##10656585 FEBS Lett. 1995 Jul 17;368(2):257-262.##Mol Plant Microbe Interact. 2000 Jan;13(1):54-61. "Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Rees SB, Broekaert WF.##Thevissen K, Osborn RW, Acland DP, Broekaert WF." "Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae.##Specific binding sites for an antifungal plant defensin from Dahlia (Dahlia merckii) on fungal cells are required for antifungal activity." DRAMP00401 DSECLKEYGGDVGFPFCAPRIFPTICYTRCRENKGAKGGRCIWGEGTNVKCLCDYCNDSPFDQ 63 Defensin-like protein 2 (MTI-2; Trypsin inhibitor 2; Plant defensin) P26780 Belongs to the DEFL family Not found Sinapis alba (White mustard) (Brassica hirta) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Inhibits bovine beta-trypsin and alpha-chymotrypsin on a 1:1 molar basis. PTM: Problely contains four disulfide bonds 4-56; 17-41; 26-51; 30-53." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7750566##1451776 FEBS Lett. 1995 May 8;364(2):179-181.##FEBS Lett. 1992 Apr 13;301(1):10-14. "Ceci LR, Spoto N, de Virgilio M, Gallerani R.##Menegatti E, Tedeschi G, Ronchi S, Bortolotti F, Ascenzi P, Thomas RM, Bolognesi M, Palmieri S." "The gene coding for the mustard trypsin inhibitor-2 is discontinuous and wound-inducible.##Purification, inhibitory properties and amino acid sequence of a new serine proteinase inhibitor from white mustard (Sinapis alba L.) seed." DRAMP00403 GIFSSRKCKTPSKTFKGICTRDSNCDTSCRYEGYPAGDCKGIRRRCMCSKPC 52 Defensin D2 (So-D2; Antimicrobial peptide D2; Plant defensin) P81571 Belongs to the DEFL family Not found Spinacia oleracea (Spinach) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Bridge Not found None "Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens. Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots. Developmental stage: Present throughout the life of the leaf. PTM: Contains four disulfide bonds (By similarity)." Gram-positive bacterium: Clavibacter michiganensis;##Gram-negative bacterium: Ralstonia solanacearum.##Fungi: Fusarium culmorum. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9762899 FEBS Lett. 1998; 435: 159-162. "Segura A, Moreno M, Molina A, Garc?a-Olmedo F." Novel defensin subfamily from spinach (Spinacia oleracea). DRAMP00404 GIFSSRKCKTVSKTFRGICTRNANC 25 Defensin D3 (So-D3; Antimicrobial peptide D3; Plant defensin) P81570 Belongs to the DEFL family Not found Spinacia oleracea (Spinach) "Antimicrobial, Antibacterial, Antifungal" Protein level Bridge Not found None "Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens. Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots. Developmental stage: Present throughout the life of the leaf." Fungi: Fusarium spp. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9762899 FEBS Lett. 1998; 435: 159-162. "Segura A, Moreno M, Molina A, Garcia-Olmedo F." Novel defensin subfamily from spinach (Spinacia oleracea). DRAMP00405 MFFSSKKCKTVSKTFRGPCVRNA 23 Defensin D4 (So-D4; Antimicrobial peptide D4; Plant defensin) P81569 Belongs to the DEFL family Not found Spinacia oleracea (Spinach) "Antimicrobial, Antibacterial, Antifungal" Protein level Bridge Not found None "Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens. Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots. Developmental stage: Present throughout the life of the leaf." Fungi: Fusarium spp. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9762899 FEBS Lett. 1998; 435: 159-162. "Segura A, Moreno M, Molina A, Garcia-Olmedo F." Novel defensin subfamily from spinach (Spinacia oleracea). DRAMP00406 MFFSSKKCKTVXKTFRGPCVRNAN 24 Defensin D5 (So-D5; Antimicrobial peptide D5; Plant defensin) P81568 Belongs to the DEFL family Not found Spinacia oleracea (Spinach) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens. Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots. Developmental stage: Present throughout the life of the leaf." "Gram-positive bacterium: Clavibacter michiganensis;##Gram-negative bacterium: Ralstonia solanacearum.##Fungi: Fusarium culmorum, Fusarium solani, Bipolaris maydis and Colletotrichum lagenarium." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9762899 FEBS Lett. 1998; 435: 159-162. "Segura A, Moreno M, Molina A, Garcia-Olmedo F." Novel defensin subfamily from spinach (Spinacia oleracea). DRAMP00407 GIFSNMYXRTPAGYFRGPXGYXXN 24 Defensin D6 (So-D6; Antimicrobial peptide D6; Plant defensin) P81567 Belongs to the DEFL family Not found Spinacia oleracea (Spinach) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens. Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots. Developmental stage: Present throughout the life of the leaf." Gram-positive bacterium: Clavibacter michiganensis (EC50=1 ?M);##Gram-negative bacterium: Ralstonia solanacearum (EC50=6 ?M).##Fungi: Fusarium solani (EC50=11 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9762899 FEBS Lett. 1998; 435: 159-162. "Segura A, Moreno M, Molina A, Garcia-Olmedo F." Novel defensin subfamily from spinach (Spinacia oleracea). DRAMP00408 GIFSSRKCKTPSKTFKGYCTRDSNCDTSCRYEGYPAGD 38 Defensin D7 (So-D7; Antimicrobial peptide D7; Plant defensin) P81573 Belongs to the DEFL family Not found Spinacia oleracea (Spinach) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None "Function: Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens. Tissue specificity: Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots. Developmental stage: Present throughout the life of the leaf." Fusarium spp. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9762899 FEBS Lett. 1998; 435: 159-162. "Segura A, Moreno M, Molina A, Garcia-Olmedo F." Novel defensin subfamily from spinach (Spinacia oleracea). DRAMP00409 KTCENLADTY 10 Defensin-like protein (Sesquin; Plant defensin) P84868 Belongs to the DEFL family Not found Vigna unguiculata subsp. sesquipedalis (Yard-Long bean) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Not found Not found None Function: Has antifungal and antibacterial activity. Has mitogenic activity towards murine splenocytes. Inhibits the proliferation of M1 leukemia and MCF-7 breast cancer cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase. "Fungi: Botrytis cinerea (IC50=2.50.01 ?M), Fusarium oxysporum (IC50=1.40.02 ?M), Mycosphaerella arachidicola (IC50=0.150.002 ?M).##Gram-positive bacteria: Bacillus megaterium, Mycobacterium phlei;##Gram-negative bacteria: Escherichia coli, Proteus vulgaris." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15949629 Peptides. 2005 Jul;26(7):1120-1126. "Wong JH, Ng TB" "Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase." DRAMP00410 QKLCERPSGTWSGVCGNNNACKNQCINLEKARHGSCNYVFPAHK 44 Defensin-like protein 1 (Bn-AFP1; Plant defensin) "P69240, P30225, Q41163" Belongs to the DEFL family AFP1 Brassica napus (Rape) "Antimicrobial, Antifungal" Protein level Rich Not found None "Function: Possesses antifungal activity sensitive to inorganic cations. Subunit structure: Forms oligomers in its native state. PTM: Problely contains one disulfide bond." "Fungi: Alternaria brassicola (IC50=3 ?g/ml), Botrytis cinerea (IC50=1.50 ?g/ml), Fusarium culmorum (IC50=2 ?g/ml), Fusarium oxysporum f.sp.lycopersici (IC50=1.80 ?g/ml), Pyricularia oryzae (IC50=0.25 ?g/ml), Verticiliium dahliae (IC50=0.80 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8422949 FEBS Lett. 1993 Feb 1;316(3):233-240. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF." A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species. DRAMP00411 QKLCERPSGTWSGVCGNNNACKN 23 Defensin-like protein 2 (Bn-AFP2; Plant defensin) P30226 Belongs to the DEFL family Not found Brassica napus (Rape) "Antimicrobial, Antifungal" Protein level Rich Not found None "Function: Possesses antifungal activity sensitive to inorganic cations. Subunit structure: Forms oligomers in its native state." "Fungi: Alternaria brassicola (IC50=75 ?g/ml), Botrytis cinerea(IC50> 100 ?g/ml), Fusarium culmorum (IC50=38 ?g/ml), Fusarium oxysporum f.sp.lycopersici (IC50=42 ?g/ml), Pyricularia oryzae (IC50=3 ?g/ml), Verticiliium dahliae (IC50=15 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8422949 FEBS Lett. 1993 Feb 1;316(3):233-240. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF." A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species. DRAMP00412 QKLCERPSGTWSGVCGNNNACKNQCIN 27 Defensin-like protein 1 (Br-AFP1; Plant defensin) P30227 Belongs to the DEFL family Not found Brassica rapa (Turnip) "Antimicrobial, Antifungal" Protein level Not found Not found None "Function: Possesses antifungal activity sensitive to inorganic cations. Subunit structure: Forms oligomers in its native state." "Fungi: Alternaria brassicola (IC50=3 ?g/ml), Botrytis cinerea(IC50=1.5 ?g/ml), Fusarium culmorum (IC50=2 ?g/ml), Fusarium oxysporum f.sp. lycopersici (IC50=1.8 ?g/ml), Pyricularia oryzae (IC50=0.25 ?g/ml), Verticiliium dahliae (IC50=0.8 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8422949 FEBS Lett. 1993 Feb 1;316(3):233-240. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF." A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species. DRAMP00413 QKLCERPSGTXSGVCGNNNACKNQCIR 27 Defensin-like protein 2 (Br-AFP2; Plant defensin) P30228 Belongs to the DEFL family Not found Brassica rapa (Turnip) "Antimicrobial, Antibacterial, Antifungal" Protein level Not found Not found None Function: Probably acts by disturbing membrane functions with its amphipathic structure (By similarity). "Fungi: Alternaria brassicola (IC50=75 ?g/ml), Botrytis cinerea(IC50>100 ?g/ml), Fusarium culmorum (IC50=38 ?g/ml), Fusarium oxysporum f.sp. lycopersici (IC50=42 ?g/ml), Pyricularia oryzae (IC50=3 ?g/ml), Verticiliium dahliae (IC50=15 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8422949 FEBS Lett. 1993 Feb 1;316(3):233-240. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF." A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species. DRAMP00415 QKLCQRPSGTWSGVCGNNNACKNQCIRLEKARHGSCNYVFPAHKCICYFPC 51 Raphanus sativus Antifungal Protein 2 (Rs-AFP2; Plant defensin) "P30230, Q003I2" Belongs to the DEFL family AFP2 Raphanus sativus (Radish) "Antimicrobial, Antifungal" Protein level Bridge Not found None "PTM: Contains four disulfide bonds 4-51;15-36;21-45;25-47, and Pyrrolidone carboxylic acid at position 1." "Fungi: Alternaria brassicola (IC50=2 ?g/ml), Ascochyta pisi (IC50=4 ?g/ml), Botrytis cinerea (IC50=2 ?g/ml), Cercospora beticola (IC50=2 ?g/ml), Colletotrichum lindemuthianum (IC50=3 ?g/ml), Fusarium culmorum (IC50=2 ?g/ml), Fusarium oxysporum f.sp.lycopersici (IC50=2 ?g/ml), Fusarium oxysporum f.sp.pisi (IC50=2 ?g/ml), Mycosphaerella fijiensis var.fijiensis (IC50=1.5 ?g/ml), Nectria haematococca (IC50=2 ?g/ml), Phoma betae (IC50=1 ?g/ml), Phytophthora infestans (IC50=25 ?g/ml), Pyrenophora tritici-repentis (IC50=1.5 ?g/ml), Pyricularia oryzae (IC50=0.4 ?g/ml), Rhizoctonia solani (IC50>100 ?g/ml), Sclerotinia sclerotiorum (IC50>100 ?g/ml), Septoria nodorum (IC50=15 ?g/ml), Trichoderma hamatum (IC50=2 ?g/ml), Verticillium dahliae (IC50=1.5 ?g/ml), Venturia inaequalis (IC50=25 ?g/ml). [NOTE: Synthetic low ionic strength growth medium]" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7780308 Plant Cell. 1995 May;7(5):573-588. "Terras FR, Eggermont K, Kovaleva V, Raikhel NV, Osborn RW, Kester A, Rees SB, Torrekens S, Van Leuven F, Vanderleyden J, et al." Small cysteine-rich antifungal proteins from radish: their role in host defense. DRAMP00418 QKLCERPSGTWSGVCGNNGACRNQCIRLERARHGSCNYVFPAHKCICYFPC 51 Hc-AFP4 (Plant defensin) No entry found Not found Hc-AFP4 Heliophila coronopifolia (South African Brassicaceae species) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Has antifungal activity. PTM: Contains four disulfide bonds." "Fungi: Botrytis cinerea (IC50=15-20 ?g/ml), Fusarium solani (IC50=5-10 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22032337 BMC Res Notes. 2011 Oct 28;4:459. "de Beer A, Vivier MA." Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding genes. DRAMP00419 RYCERSSGTWSGVCGNTDKCSSQCQRLEGAAHGSCNYVFPAHKCICYYPC 50 Hc-AFP3 (Plant defensin) No entry found Not found Hc-AFP3 Heliophila coronopifolia (South African Brassicaceae species) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Has antifungal activity. PTM: Contains four disulfide bonds." "Fungi: Botrytis cinerea (IC50=20-25 ?g/ml), Fusarium solani (IC50>25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22032337 BMC Res Notes. 2011 Oct 28;4:459. "de Beer A, Vivier MA." Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding genes. DRAMP00420 QKLCERPSGTWSGVCGNNNACRNQCINLEKARHGSCNYVFPAHKCICYFPC 51 Hc-AFP2 (Plant defensin) No entry found Not found Hc-AFP2 Heliophila coronopifolia (South African Brassicaceae species) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Has antifungal activity. PTM: Contains four disulfide bonds." "Fungi: Botrytis cinerea (IC50=10-15 ?g/ml), Fusarium solani (IC50=10-15 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22032337 BMC Res Notes. 2011 Oct 28;4:459. "de Beer A, Vivier MA." Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding genes. DRAMP00421 RYCERSSGTWSGVCGNSGKCSNQCQRLEGAAHGSCNYVFPAHKCICYYPC 50 Hc-AFP1 (Plant defensin) No entry found Not found Hc-AFP1 Heliophila coronopifolia (South African Brassicaceae species) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Has antifungal activity. PTM: Contains four disulfide bonds." "Fungi: Botrytis cinerea (IC50>25 ?g/ml), Fusarium solani (IC50>25 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22032337 BMC Res Notes. 2011 Oct 28;4:459. "de Beer A, Vivier MA." Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding genes. DRAMP00424 QKLCERSSGTWSGVCGNNNACKNQCINLEGARHGSCNYVFPYHRCICYFPC 50 Br-AFP1 (Defensin 1.2; Plant defensin) No entry found Not found Not found Brassica rapa subsp. Chinensis "Antimicrobial, Antifungal" Not found Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8422949##7628617 FEBS Lett. 1993 Feb 1;316(3):233-240.##FEBS Lett. 1995 Jul 17;368(2):257-262. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF.##Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Rees SB, Broekaert WF." "A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species.##Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae." DRAMP00426 DGVKLCDVPSGTWSGHCGSSSKCSQQCKDREHFAYGGACHYQFPSVKCFCKRQC 54 Defensin-like protein 1 (Hs-AFP1; Plant defensin) "Q7M1F4, P0C8Y5" Belongs to the DEFL family Not found Heuchera sanguinea (Coralbells) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Possesses antifungal activity insensitive to inorganic cations. Causes germ tubes and hyphae to swell and form multiple hyphal buds. Binds to the plasma membrane of the fungus. Has no inhibitory effect on insect gut alpha-amylase. PTM: Contains four disulfide bonds (By similarity)." "Fungi: Botrytis cinerea (IC50=6 ?g/ml), Cladosporium sphaerospermum (IC50=1 ?g/ml), Fusarium culmorum (IC50=1 ?g/ml), Leptosphaeria maculans (IC50=25 ?g/ml), Penicillium digitatum (IC50=1?g/ml), Trichoderma viride (IC50=15 ?g/ml), Septoria tritiei (IC50=0.5 ?g/ml), Verticillium albo-atrum (IC50=0.5 ?g/ml), Neurospora crassa (IC50=12 ?g/ml). " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet "chitin, mannan, galactocerebrosides, and sphingomyelin (Mycopathologia. 1998-1999;144:87-91)" 7628617##9405418##16284838 FEBS Lett. 1995 Jul 17;368(2):257-262.##J Biol Chem. 1997 Dec 19;272(51):32176-32181.##Mycopathologia. 1998-1999;144(2):87-91. "Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Rees SB, Broekaert WF.##Thevissen K, Osborn RW, Acland DP, Broekaert WF.##De Lucca AJ, Jacks TJ, Broekaert WJ." "Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae.##Specific, high affinity binding sites for an antifungal plant defensin on Neurospora crassa hyphae and microsomal membranes.##Fungicidal and binding properties of three plant peptides." DRAMP00427 AICKKPSKFFKGACGRDADCEKACDQENWPGGVCVPFLRCECQRSC 46 Defensin-like protein AX1 (Antifungal protein AX1; Plant defensin) P81493 Belongs to the DEFL family Not found Beta vulgaris (Sugar beet) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Not found Not found None "Function: Strong inhibiting activity against C. beticola and other filamentous fungi. Little or no effect against bacteria. Tissue specificity: Leaves and flowers. PTM: Contains four disulfide bonds 3-46; 14-34; 20-40; 24-42 (By similarity)." "Fungi: Cercospora beticola, Botrytis cinerea, Fusarium graminearum, Bipolaris maydis." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7655063 Mol Plant Microbe Interact. 1995 May-Jun;8(3):424-434. "Kragh KM, Nielsen JE, Nielsen KK, Dreboldt S, Mikkelsen JD." Characterization and localization of new antifungal cysteine-rich proteins from Beta vulgaris. DRAMP00428 ATCRKPSMYFSGACFSDTNCQKACNREDWPNGKCLVGFKCECQRPC 46 Defensin-like protein AX2 (Antifungal protein AX2; Cys-rich; Plant defensin) "P82010, P81510" Belongs to the DEFL family Not found Beta vulgaris (Sugar beet) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Not found Not found None "Function: Strong inhibiting activity against C. beticola and other filamentous fungi. Little or no effect against bacteria. Tissue specificity: Leaves and flowers. PTM: Contains four disulfide bonds 3-46; 14-34; 20-40; 24-42 (By similarity)." "Fungi: Cercospora beticola, Botrytis cinerea, Fusarium graminearum, Bipolaris maydis." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7655063 Mol Plant Microbe Interact. 1995 May-Jun;8(3):424-434. "Kragh KM, Nielsen JE, Nielsen KK, Dreboldt S, Mikkelsen JD." Characterization and localization of new antifungal cysteine-rich proteins from Beta vulgaris. DRAMP00429 LCNERPSQTWSGNCGNTAHCDKQCQDWEKASHGACHKRENHWKCFCYFNC 50 Aesculus hippocastanum antimicrobial protein 1 (Ah-AMP1; Cys-rich; Plant defensin) Q7M1F3 Belongs to the DEFL family Not found Aesculus hippocastanum (Horse chestnut) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal" Protein level Combine helix and strand structure Not found 1BK8 resolved by NMR. "Function: Possesses antimicrobial activity sensitive to inorganic cations. Binds specifically to the fungal plasma membrane. Has no inhibitory effect on insect gut alpha-amylase. PTM: Contains four disulfide bonds 2-50; 14-35; 20-44; 24-46 (By similarity)." "Gram-positive bacterium: Bacillus subtilis (IC50=100 ?g/mL).##Fungi: [MA: Botrytis cinerea (IC50=25 ?g/mL), Cladosporium sphaerospermum (IC50=0.5 ?g/mL), Fusarium culmorum (IC50=12 ?g/mL), Leptosphaeria maculans (IC50=0.5 ?g/mL), Penicillium digitatum (IC50=6 ?g/mL), Trichoderma viride (IC50>100 ?g/mL), Septoria tritiei (IC50=0.5 ?g/mL), Verticilium albo-atrum (IC50=6 ?g/mL). MA+: Botrytis cinerea (IC50>100 ?g/mL), Cladosporium sphaerospermum (IC50=12 ?g/mL), Fusarium culmorum (IC50>100 ?g/mL), Leptosphaeria maculans (IC50=6 ?g/mL), Penicillium digitatum (IC50=25 ?g/mL), Trichoderma viride (IC50>100 ?g/mL), Septoria tritiei (IC50=1.5 ?g/mL), Verticilium albo-atrum (IC50>100 ?g/mL)].##NOTE: MA+ = MA supplemented with 1 mM CaCl2 and 50 mM KCl." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Binds specifically to the fungal plasma membrane. 7628617##10591099##10656585 FEBS Lett. 1995 Jul 17;368(2):257-262.##Proteins. 1999 Nov 15;37(3):388-403.##Mol Plant Microbe Interact. 2000 Jan;13(1):54-61. "Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Rees SB, Broekaert WF.##Fant F, Vranken WF, Borremans FA.##Thevissen K, Osborn RW, Acland DP, Broekaert WF." "Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae.##The three-dimensional solution structure of Aesculus hippocastanum antimicrobial protein 1 determined by 1H nuclear magnetic resonance.##Specific binding sites for an antifungal plant defensin from Dahlia (Dahlia merckii) on fungal cells are required for antifungal activity." DRAMP00432 RVCRRRSAGFKGVCMSDHNCAQVCLQEGYGGGNCDGIMRQCKCIRQC 47 Defensin-like protein 1 (Gamma-zeathionin-1; Plant defensin) P81008 Belongs to the DEFL family Not found Zea mays (Maize) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Sodium channel blocker. PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Protein Pept. Lett. 1996;3:267-274. "Castro M.S, Fontes W, Morhy L, Bloch C. Jr." Complete amino acid sequences of two gamma-thionins from maize (Zea mays L.) seeds. DRAMP00433 RVCMGKSQHHSFPCISDRLCSNECVKEDGGWTAGYCHLRYCRCQKAC 47 Defensin-like protein 2 (Gamma-zeathionin-2; Plant defensin) P81009 Belongs to the DEFL family Not found Zea mays (Maize) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Sodium channel blocker. PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Protein Pept. Lett. 1996;3:267-274. "Castro M.S, Fontes W, Morhy L, Bloch C. Jr." Complete amino acid sequences of two gamma-thionins from maize (Zea mays L.) seeds. DRAMP00434 KICRRRSAGFKGPCMSNKNCAQVCQQEGWGGGNCDGPFRRCKCIRQC 47 Defensin-like protein 1 (Gamma-1-purothionin; Plant defensin) P20158 Belongs to the DEFL family Not found Triticum aestivum (Wheat) "Antimicrobial, Antifungal" Protein level Bridge "Gamma 1-P has a well-defined triple-stranded antiparallel beta-sheet (residues 1-6, 31-34, and 39-47), an alpha-helix (residues 16-28), and the corresponding connecting loops. Three disulfide bridges are located in the hydrophobic core holding together the alpha-helix and the beta-sheet and forming a cysteine-stabilized alpha-helical (CSH) motif." None PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2226781##8380707 FEBS Lett. 1990 Sep 17;270(1-2):191-194.##Biochemistry. 1993 Jan 19;32(2):715-724. "Colilla FJ, Rocher A, Mendez E.##Bruix M, Jim?nez MA, Santoro J, Gonz?lez C, Colilla FJ, M?ndez E, Rico M. " Gamma-Purothionins: amino acid sequence of two polypeptides of a new family of thionins from wheat endosperm.##Solution structure of gamma 1-H and gamma 1-P thionins from barley and wheat endosperm determined by 1H-NMR: a structural motif common to toxic arthropod proteins. DRAMP00435 KVCRQRSAGFKGPCVSDKNCAQVCLQEGWGGGNCDGPFRRCKCIRQC 47 Defensin-like protein 2 (Gamma-2-purothionin; Plant defensin) P20159 Belongs to the DEFL family Not found Triticum aestivum (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2226781 FEBS Lett. 1990 Sep 17;270(1-2):191-194. "Colilla FJ, Rocher A, Mendez E. " Gamma-Purothionins: amino acid sequence of two polypeptides of a new family of thionins from wheat endosperm. DRAMP00438 KSTCKAESNTFPGLCITKPPCRKACLSEKFTDGKCSKILRRCICYKPCVFDGKMIQTGAENLAEEAETLAAALLEEEMMDN 81 Defensin-like protein 1 (Gamma-thionin 1; Plant defensin) O24115 Belongs to the DEFL family THIO1 Nicotiana paniculata "Antimicrobial, Antifungal" Transcript level Bridge Not found None PTM: Contains four disulfide bonds 4-48; 15-35; 21-42; 25-44. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Plant Gene Register PGR97-132. "Komori T, Yamada S, Imaseki H." A cDNA clone for gamma-thionin from Nicotiana paniculata. DRAMP00439 RTCESQSHRFHGTCVRESNCASVCQTEGFIGGNCRAFRRRCFCTRNC 47 Defensin-like protein (Gamma-thionin homolog PPT; Plant defensin) Q40901 Belongs to the DEFL family Not found Petunia integrifolia (Violet-flowered petunia) "Antimicrobial, Antifungal" Transcript level Bridge Not found None "Function: May be involved in the defense of the pistil against pathogen infection. Tissue specificity: Predominantly expressed in the pistil during all stages of flower development. PTM: Contains four disulfide bonds 3-47; 14-34; 20-21; 24-43 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7948892 Plant Mol Biol. 1994 Oct;26(1):459-464. "Karunanandaa B, Singh A, Kao TH." Characterization of a predominantly pistil-expressed gene encoding a gamma-thionin-like protein of Petunia inflata. DRAMP00440 NEMGGPLVVEARTCESQSHKFKGTCLSDTNCANVCHSERFSGGKCRGFRRRCFCTTHC 58 Defensin SD2 (Plant defensin) P82659 Belongs to the DEFL family SD2 Helianthus annuus (Common sunflower) "Antimicrobial, Antifungal" Transcript level Bridge Not found None "Function:May play a protective role in flowers by protecting the reproductive organs from potential pathogen attack. Tissue specificity: Highest expression in flowers and to a lesser extent in leaves. Lower levels in hypocotyls. No expression in roots and cotyledons. Developmental stage:Expressed progressively during flower development reaching the highest level in the mature fertilized flower stage. PTM: Problely contains four disulfide bonds 14-57; 25-44; 31-52; 35-54." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Plant Physiol. Biochem. 2000;38:253-258. "Urdangarin M.C, de la Canal L." A defensin gene expressed in sunflower inflorescence. DRAMP00441 RTCQSQSHKFKGACFSDTNCDSVCRTENFPRGQCNQHHVERKCYCERDC 49 Defensin Tk-AMP-D1 (Plant defensin) P84963 Belongs to the DEFL family Not found Triticum kiharae (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Has weak antifungal activity, but not against A. consortiale Botrytis cinerea, H. sativum, F. culmorum, C. graminicola and D. maydis. PTM: Contains four disulfide bonds 3-49; 14-34; 20-43; 24-45 (By similarity)." Fungi: Fusarium graminearum and Fusarium verticillioides (MIC<30 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030##18625284 Biochimie. 2007 May;89(5):605-612.##Biochimie. 2008 Nov-Dec;90(11-12):1667-1673. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV.##Odintsova TI, Rogozhin EA, Baranov Y, Musolyamov AKh, Yalpani N, Egorov TA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes.##Seed defensins of barnyard grass Echinochloa crusgalli (L.) Beauv. DRAMP00442 RDCESDSHKFHGACFSDTNCANVCQTEGFTAGKCVGVQRHCHCTKDC 47 Defensin Tk-AMP-D1.1 (Plant defensin) P84965 Belongs to the DEFL family Not found Triticum kiharae (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Plant defense peptide (By similarity). PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030 Biochimie. 2007 May;89(5):605-612. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes. DRAMP00443 RTCESQSHKFKGPCFSDSNCATVCRTENFPRGQCNQHHVERKCYCERSC 49 Defensin Tk-AMP-D2 (Plant defensin) P84968 Belongs to the DEFL family Not found Triticum kiharae (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Plant defense peptide (By similarity). PTM: Contains four disulfide bonds 3-49; 14-34; 20-43; 24-45 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030 Biochimie. 2007 May;89(5):605-612. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes. DRAMP00444 RDCKSDSHKFHGACFSDTNCANVCQTEGFTRGKCDGIHCHCIKDC 45 Defensin Tk-AMP-D3 (Plant defensin) P84970 Belongs to the DEFL family Not found Triticum kiharae (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Plant defense peptide (By similarity). PTM: Contains four disulfide bonds 3-45; 14-34; 20-39; 24-41 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030 Biochimie. 2007 May;89(5):605-612. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes. DRAMP00445 RDCTSQSHKFVGLCLSDRNCASVCLTEYFTGGKCDHRRCVCTKGC 45 Defensin Tk-AMP-D4 (Plant defensin) P84971 Belongs to the DEFL family Not found Triticum kiharae (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Plant defense peptide (By similarity). PTM: Contains four disulfide bonds 3-45; 14-34; 20-39; 24-41 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030 Biochimie. 2007 May;89(5):605-612. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes. DRAMP00446 RECRSESKKFVGLCVSDTNCASVCLTERFPGGKCDGYRRCFCTKDC 46 Defensin Tk-AMP-D5 (Plant defensin) P84966 Belongs to the DEFL family Not found Triticum kiharae (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Plant defense peptide (By similarity). PTM: Contains four disulfide bonds 3-46; 14-34; 20-40; 24-42 (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030 Biochimie. 2007 May;89(5):605-612. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes. DRAMP00447 RDCRSQSKTFVGLCVSDTNCASVCLTEHFPGGKCDGYRRCFCTKDC 46 Defensin Tk-AMP-D6 (Plant defensin) P84967 Belongs to the DEFL family Not found Triticum kiharae (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Plant defense peptide (By similarity). PTM: Contains four disulfide bonds 3-46; 14-34; 20-40; 24-42 (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030 Biochimie. 2007 May;89(5):605-612. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes. DRAMP00448 RECRSQSKQFVGLCVSDTNCASVCLTEHFPGGKCDGYRRCFCTKDC 46 Defensin Tk-AMP-D6.1 (Plant defensin) P84969 Belongs to the DEFL family Not found Triticum kiharae (Wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Plant defense peptide (By similarity). PTM: Contains four disulfide bonds 3-46; 14-34; 20-40; 24-42 (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030 Biochimie. 2007 May;89(5):605-612. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes. DRAMP00449 RTCQSQSHKFKGACFSDTNCASVCRTENFPRGQCNQHHVERKCYCERDC 49 Defensin Tm-AMP-D1.2 (Plant defensin) P84964 Belongs to the DEFL family Not found Triticum monococcum (Einkorn wheat) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Plant defense peptide (By similarity). PTM: Contains four disulfide bonds 3-49; 14-34; 20-43; 24-45 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17321030 Biochimie. 2007 May;89(5):605-612. "Odintsova TI, Egorov TA, Musolyamov AKh, Odintsova MS, Pukhalsky VA, Grishin EV." Seed defensins from T. kiharae and related species: genome localization of defensin-encoding genes. DRAMP00451 QKLCARPSGTWSSGNCRNNNACRNFCIKLEKSRHGSCNIPFPSNKCICYFPC 52 Defensin-like protein 2B (AFP2b; M2B; Plant defensin) Q10989 Belongs to the DEFL family Not found Sinapis alba (White mustard) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Function: Possesses antifungal activity sensitive to inorganic cations. Subunit structure: Forms oligomers in its native state. PTM: Contains four disulfide bonds 4-52; 16-37; 22-46; 26-48 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8836771 Int J Pept Protein Res. 1996 Jun;47(6):437-446. "Neumann GM, Condron R, Polya GM." Purification and mass spectrometry-based sequencing of yellow mustard (Sinapis alba L.) 6 kDa proteins. Identification as antifungal proteins. DRAMP00452 KICEALSGNFKGLCLSSRDCGNVCRREGFTDGSCIGFRLQCFCTKPCA 48 Defensin J1-1 (Plant defensin) Q43413 Belongs to the DEFL family Not found Capsicum annuum (Bell pepper) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Tissue specificity: Expressed in orange and red ripe fruit and to a lesser extent in mature, green fruit. Present in trace in young, green fruit. PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43." "Fungi: Fusarium oxysporum, Botrytis cinerea." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8883377 Plant Physiol. 1996 Oct;112(2):615-622. "Meyer B, Houln? G, Pozueta-Romero J, Schantz ML, Schantz R." Fruit-specific expression of a defensin-type gene family in bell pepper. Upregulation during ripening and upon wounding. DRAMP00453 RTCESQSHRFKGLCFSKSNCGSVCHTEGFNGGHCRGFRRRCFCTRHC 47 Defensin J1-2 (Plant defensin) O65740 Belongs to the DEFL family Not found Capsicum annuum (Bell pepper) "Antimicrobial, Antifungal" Protein level Bridge Not found None "Tissue specificity: Expressed in flowers and in young fruits. PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43." "Fungi: Fusarium oxysporum, Botrytis cinerea." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8883377##9790581 Plant Physiol. 1996 Oct;112(2):615-622.##Mol Gen Genet. 1998 Sep;259(5):504-510. "Meyer B, Houln? G, Pozueta-Romero J, Schantz ML, Schantz R.##Houln? G, Meyer B, Schantz R." Fruit-specific expression of a defensin-type gene family in bell pepper. Upregulation during ripening and upon wounding.##Alteration of the expression of a plant defensin gene by exon shuffling in bell pepper (Capsicum annuum L.). DRAMP00457 RTCESKSHRFKGPCVSTHNCANVCHNEGFGGGKCRGFRRRCYCTRHC 47 Defensin-like protein 1 (LCR68; Plant defensin 2.3; Plant defensin) "Q9ZUL7, Q4VP02" Belongs to the DEFL family PDF2.3 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Bridge Not found None "Tissue specificity: Expressed in the whole plant except roots. PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637 Plant Biotechnol J. 2006 May;4(3):317-324. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations. DRAMP00458 RTCESQSHRFKGTCVSASNCANVCHNEGFVGGNCRGFRRRCFCTRHC 47 Defensin-like protein 2 (LCR69; Plant defensin 2.2; Plant defensin) "Q39182, Q42011, Q4VP00, Q4VP03" Belongs to the DEFL family PDF2.2 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Bridge Not found None "Function: Confers broad-spectrum resistance to pathogens. Tissue specificity: Broadly expressed. PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##8281187 Plant Mol Biol. 2001 May;46(1):17-34.##Plant J. 1993 Dec;4(6):1051-1061.##Plant Physiol. Biochem. 1998;36:533-537. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##H?fte H, Desprez T, Amselem J, Chiapello H, Rouz? P, Caboche M, Moisan A, Jourjon MF, Charpenteau JL, Berthomieu P, et al.##Thomma B.P.H.J, Broekaert W.F." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##An inventory of 1152 expressed sequence tags obtained by partial sequencing of cDNAs from Arabidopsis thaliana.##Tissue-specific expression of plant defensin genes PDF2.1 and PDF2.2 in Arabidopsis thaliana. DRAMP00459 RICKSRSQKFKGPCVSEDNCANVCHTEGFPDGDCDGLLRRCYCNTHC 47 Defensin-like protein 3 (Protein LCR71; Plant defensin) P82781 Belongs to the DEFL family LCR71 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Bridge Not found None PTM: Contains four disulfide bonds 3-47;14-34;20-41;24-43. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247 Plant Mol Biol. 2001 May;46(1):17-34. "Vanoosthuyse V, Miege C, Dumas C, Cock JM." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response. DRAMP00460 RTCASQSQRFKGKCVSDTNCENVCHNEGFPGGDCRGFRRRCFCTRNC 47 Defensin-like protein 4 (Protein LCR70; Plant defensin 2.1; Plant defensin) "Q41914, Q541X5, Q9ZUL6" Belongs to the DEFL family PDF2.1 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Bridge Not found None "Function: Confers broad-spectrum resistance to pathogens. Tissue specificity: Expressed in roots, siliques and seeds. PTM: Contains four disulfide bonds 3-47; 14-34; 20-41; 24-43 (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##8281187 Plant Mol Biol. 2001 May;46(1):17-34.##Plant J. 1993 Dec;4(6):1051-1061. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##H?fte H, Desprez T, Amselem J, Chiapello H, Rouz? P, Caboche M, Moisan A, Jourjon MF, Charpenteau JL, Berthomieu P, et al." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##An inventory of 1152 expressed sequence tags obtained by partial sequencing of cDNAs from Arabidopsis thaliana. DRAMP00461 RTCETSSNLFNGPCLSSSNCANVCHNEGFSDGDCRGFRRRCLCTRPC 47 Defensin-like protein 5 (Protein LCR66; Plant defensin 2.4; Plant defensin) "Q9C947, A0MED6, Q1PFI2, Q8LEG6" Belongs to the DEFL family PDF2.4 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Bridge Not found None "PTM: Contains four disulfide bonds 4-51; 15-36; 21-45; 25-47, and Pyrrolidone carboxylic acid at position 1." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637 Plant Biotechnol J. 2006 May;4(3):317-324. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations. DRAMP00462 RTCQSKSHHFKYMCTSNHNCAIVCRNEGFSGGRCHGFHRRCYCTRLC 47 Defensin-like protein 6 (Protein LCR74; Plant defensin 2.5; Plant defensin) "Q9FFP8, P82783" Belongs to the DEFL family PDF2.5 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Bridge Not found None PTM: Contains four disulfide bonds 4-47; 14-34; 20-41; 24-43. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247 Plant Mol Biol. 2001 May;46(1):17-34. "Vanoosthuyse V, Miege C, Dumas C, Cock JM." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response. DRAMP00463 QQMCEAKSLDWKGMCLKWRNCRQVCISEGFTDGRCKGFTRKCICSKPCFVLPN 53 Defensin-like protein 7 (Protein LCR75; LCR79; Plant defensin) "P82784, P82788" Belongs to the DEFL family LCR75 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Bridge Not found None "Tissue specificity: Expressed in stems, roots, rosette leaves and flower buds. PTM: Contains four disulfide bonds 4-48;15-35;21-42;25-44." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247 Plant Mol Biol. 2001 May;46(1):17-34. "Vanoosthuyse V, Miege C, Dumas C, Cock JM." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response. DRAMP00465 QPQLCETKSLNYRGLCLKWRSCKRVCISEGFPDGRCKGFFNNKCVCRKPCALLSTEN 57 Defensin-like protein 9 (Protein LCR76; Plant defensin) P82785 Belongs to the DEFL family LCR76 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Bridge Not found None PTM: Contains four disulfide bonds 5-50;16-36;22-44;26-46. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247 Plant Mol Biol. 2001 May;46(1):17-34. "Vanoosthuyse V, Miege C, Dumas C, Cock JM." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response. DRAMP00466 RTCESPSNKFQGVCLNSQSCAKACPSEGFSGGRCSSLRCYCSKAC 45 Defensin-like protein 10 (Protein LCR72; Plant defensin 2.6; Plant defensin) "Q9ZUL8, Q0IGN8" Belongs to the DEFL family PDF2.6 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Bridge Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247 Plant Mol Biol. 2001 May;46(1):17-34. "Vanoosthuyse V, Miege C, Dumas C, Cock JM." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response. DRAMP00467 QKCEWECKLLPNFPCWLKGAGEGLCDNLCKYEGAISGVCVSDPHRCLCRNRKPGCS 56 Defensin-like protein 11 (Plant defensin) "Q9M1V4, A0MF42" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Bridge Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00468 QMNDCDCDHDHRCGEWEDESHGNCKQHHLRVVCTCTLDCLDISSTSNA 48 Putative defensin-like protein 12 (Plant defensin) Q2V477 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Bridge Not found None "Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00469 QKLCERPSGTWSGVCGNSNACKNQCINLEKARHGSCNYVFPAHKCICYFPC 51 Defensin-like protein 13 (At-AFP1; Protein LCR67; Plant defensin) "P30224, Q42179" Belongs to the DEFL family PDF1.1 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Protein level Rich Not found None "Function: Confers broad-spectrum resistance to pathogens. Possesses antifungal activity sensitive to inorganic cations in vitro. Tissue specificity: Expressed predominantly in siliques and dry seeds. PTM: Contains four disulfide bonds 4-51; 15-36; 21-45; 25-47, and pyrrolidone carboxylic acid at Q1." "Fungi: Alternaria brassicola (IC50=10 ?g/ml), Botrytis cinerea (IC50=3.90 ?g/ml), Fusarium culmorum (IC50=3 ?g/ml), Fusarium oxysporum f.sp. lycopersici (IC50=3 ?g/ml), Pyricularia oryzae (IC50=0.25 ?g/ml), Verticiliium dahliae (IC50=1.50 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8422949##17180735##8989885 FEBS Lett. 1993 Feb 1;316(3):233-240.##Transgenic Res. 2007 Aug;16(4):531-538.##Plant Cell. 1996 Dec;8(12):2309-2323. "Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF.##Sels J, Delaur? SL, Aerts AM, Proost P, Cammue BP, De Bolle MF.##Penninckx IA, Eggermont K, Terras FR, Thomma BP, De Samblanx GW, Buchala A, M?traux JP, Manners JM, Broekaert WF." A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species.##Use of a PTGS-MAR expression system for efficient in planta production of bioactive Arabidopsis thaliana plant defensins.##Pathogen-induced systemic activation of a plant defensin gene in Arabidopsis follows a salicylic acid-independent pathway. DRAMP00470 QKLCEKPSGTWSGVCGNSNACKNQCINLEGAKHGSCNYVFPAHKCICYFPC 51 Defensin-like protein 14 (Plant defensin 1.3; Plant defensin) O80995 Belongs to the DEFL family PDF1.3 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "PTM: Contains four disulfide bonds 4-51;15-36;21-45;25-47, and Pyrrolidone carboxylic acid at position 1." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10617197 Nature. 1999 Dec 16;402(6763):761-768. "Lin X, Kaul S, Rounsley S, Shea TP, Benito MI, Town CD, Fujii CY, Mason T, Bowman CL, Barnstead M, Feldblyum TV, Buell CR, Ketchum KA, Lee J, Ronning CM, Koo HL, Moffat KS, Cronin LA, Shen M, Pai G, Van Aken S, Umayam L, Tallon LJ, Gill JE, Adams MD, Carr" Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. DRAMP00474 LCKRESETWSGRCVNDYQCRDHCINNDRGNDGYCAGGYPWYRSCFCFFSC 50 Defensin-like protein 18 (Plant defensin 1.5; Plant defensin) Q9FZ31 Belongs to the DEFL family PDF1.5 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Confers broad-spectrum resistance to pathogens. PTM: Contains four disulfide bonds 3-51; 14-35; 20-45; 24-47." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924##12447532 Plant Physiol. 2005 Jun;138(2):600-610.##Planta. 2002 Dec;216(2):193-202. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Thomma BP, Cammue BP, Thevissen K." Genome organization of more than 300 defensin-like genes in Arabidopsis.##Plant defensins. DRAMP00475 TEMMAVEGRICERRSKTWTGFCGNTRGCDSQCKRWERASHGACHAQFPGFACFCYFNC 58 Defensin-like protein 19 (Protein LCR78; Plant defensin 1.4; Plant defensin) "P82787, Q8VZQ7, Q9FWR6" Belongs to the DEFL family PDF1.4 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Bridge Not found None PTM: Contains four disulfide bonds 11-58;22-43;28-52;32-54. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247 Plant Mol Biol. 2001 May;46(1):17-34. "Vanoosthuyse V, Miege C, Dumas C, Cock JM." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response. DRAMP00476 QKHIAPWIFEDKSICCKEHPSVGRCLPGIDDDAEKDGKCWKFCIEGCETGGFCKLFEHKHICHCNCSG 68 Putative defensin-like protein 20 (Plant defensin) Q2V2S1 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00477 QKHTAPWIPEDNSICCKEHPSVGRCLPNIDDSAEKGGKCWKFCIEGCETGGFCKLFGHKHICHCNCSG 68 Defensin-like protein 21 (Plant defensin) "P0CAX9, O23285, Q2V3I6" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Bridge Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00478 YNVENGGSLCCNNHPKFGKCNTKNDDQRCNSWCLNGCDNGKGGYCKSMSHGGQCHCYC 58 Defensin-like protein 22 (Plant defensin) Q2V391 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00479 SGSSLCCNTHAKFGACNTYQDRKRCNKWCLDGCDNKKGGFCKRFAGGAKKCHCYC 55 Putative defensin-like protein 23 (Plant defensin) Q2V364 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00480 RKTVWPSSELDPKCCSNQPEFGICDSKEDDERCAQMCLDGCPTNKGGGCQPITEAPGAVCSCYCA 65 Defensin-like protein 24 (Plant defensin) Q2V371 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00481 YNVESGGSLCCNNHPKFGKCNTNNDNQRCNRWCHNGCGNGKGDYCKAMSHGGLCHCYC 58 Putative defensin-like protein 25 (Plant defensin) Q2V392 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00482 MIYNVESGGSLCCNSHPKFGKCNTNNDEQRCNRWCHNGCGNGKGGYYKSMSHGGQCHYYC 60 Putative defensin-like protein 26 (Plant defensin) Q2V4J2 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None PTM: Problely contains two disulfide bonds. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00483 VMNEDSILSSNKGDSLCCNDHPEFGICTNKSCNKWCLQGCTRGGFCKRKICHCYC 55 Putative defensin-like protein 27 (Plant defensin) Q2L6T3 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00484 KENITPWIYSMKQPVSCNREHSEIGICLSGIDDDIQNDGKCWKFCLMVAKSGGYNADK 58 Putative defensin-like protein 28 (Plant defensin) "P0CAY0, F4JUP3, O23285" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00485 KSMVEVNAAHKWYIVEGLCSKFPDCNKHCKEQKFPGGTCLKLGVNMMCTCIYS 53 Putative defensin-like protein 29 (Plant defensin) Q2V3R9 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924##10907853 Plant Physiol. 2005 Jun;138(2):600-610.##DNA Res. 2000 Jun 30;7(3):217-221. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Kaneko T, Katoh T, Sato S, Nakamura A, Asamizu E, Tabata S." "Genome organization of more than 300 defensin-like genes in Arabidopsis.##Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones." DRAMP00486 KSMAKAQGGWYLVEGLCSKFPDCNKHCKEQGFLGGQCLKLGVNMLCFCIHT 51 Putative defensin-like protein 30 (Plant defensin) Q2V3S0 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Caution: Could be the product of a pseudogene. Lacks the signal peptide, which is a conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924##10907853 Plant Physiol. 2005 Jun;138(2):600-610.##DNA Res. 2000 Jun 30;7(3):217-221. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Kaneko T, Katoh T, Sato S, Nakamura A, Asamizu E, Tabata S." "Genome organization of more than 300 defensin-like genes in Arabidopsis.##Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones." DRAMP00487 EDRSKLIPIGPCSKIANCNQTCIESQFLGGKCIKWYPDSIKETCACLVKPSITHV 55 Putative defensin-like protein 31 (Plant defensin) Q2V3D7 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00488 KDIDGRKPLLIGTCIEFPTEKCNKTCIESNFAGGKCVHIGQSLDFVCVCFPKYYI 55 Defensin-like protein 32 (Plant defensin) Q2V4I8 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00489 QNPRGRKCEDPNGVDQKAKCYIYCNEQGFLGGSCQGYTNHYMCECYVG 48 Putative defensin-like protein 33 (Plant defensin) Q2V4D6 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00490 QILTGIKCPDPNGHDKEDKCNIYCLNQNYMGGSCQGYKNHYMCECYVG 48 Defensin-like protein 34 (Plant defensin) Q2V4D7 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00491 KSMNPTGRRCPDPNGVEKKSMCYSSCKTQGFMGGSCQGHKGNYMCECYEG 50 Defensin-like protein 35 (Plant defensin) "Q2V4F3, Q9SH70" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00492 IESPIFTGNKCSDPTGMDKDGKCLDYCHAQGYPGGSCIGFIDQGYMCVCKVG 52 Putative defensin-like protein 36 (Plant defensin) Q2V4D5 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00493 TTAGRRDGKSGRTEWLYVAGECAKLPRCNKYCVSNGFHLGGFCEKLSPQASYLSCVCKYT 60 Defensin-like protein 37 (Plant defensin) "Q56XC2, F4JSA4, Q9SVQ4" Belongs to the DEFL family EDA21 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00494 YCERVRSRSAPHDICKKKNGNAVCKEKCWTIEKYQNGRCLILPKTTKLDCYCYHFDQC 58 Putative defensin-like protein 38 (Plant defensin) Q2V462 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00495 YCEKVRSKTAPRDVCKKSNGNALCKKTCWTIEKYVNGKCLILPKTTNLDCYCYHYDNGSACRA 63 Putative defensin-like protein 39 (Plant defensin) Q2V460 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00496 LGTSPYCEKVLSRFAPPGNCLKKNGNALCKESCANEQFREGVCLHLPKPQSKLNCYCSVLKCP 63 Putative defensin-like protein 40 (Plant defensin) Q2V325 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00497 MTQGKRKHPCDLKNPSKRAPPATCNKPNGAILCGDFCLHEGYNIGKCVMRRTGKACICSQCEGW 64 Defensin-like protein 41 (Plant defensin) Q3E8B0 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00498 MNWELCDDYPSKAPPETCNKVDGARRCRTSCNNEGYGGANCNLKGKVKVCECTILRVCLPHHKRPPHVPKPPK 73 Putative defensin-like protein 42 (Plant defensin) P0CAY1 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "PTM: Contains four disulfide bonds (By similarity). Caution: Could be the product of a pseudogene. Lacks the signal peptide, which is a conserved feature of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924##10907853 Plant Physiol. 2005 Jun;138(2):600-610.##DNA Res. 2000 Jun 30;7(3):217-221. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Kaneko T, Katoh T, Sato S, Nakamura A, Asamizu E, Tabata S." "Genome organization of more than 300 defensin-like genes in Arabidopsis.##Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones." DRAMP00499 SEIKPTGRIDDQCKQMCSATYGDGKCASDCRKAGFSSGRCLTSSPFGNKCCCTK 54 Defensin-like protein 43 (Plant defensin) Q2V4J5 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00500 SEIKPTGRVDNQCKEMCSATFGDGKCAADCRKAGFSSGRCLTSSPFGNKCCCT 53 Defensin-like protein 44 (Plant defensin) Q9M833 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00501 SDIKPTGRIDNQCKRMCSATYGNGKCAADCRSDGFSSGQCFTSPPFDNRCCCNN 54 Defensin-like protein 45 (Plant defensin) Q2V3Y8 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00502 IDAGIKGFDTDHCDTRCYGRDECMNYCIKAGFPKGGQCGSLCIPCGFKCCCQK 53 Defensin-like protein 46 (Plant defensin) "Q2V3V1, A0ME04" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00503 SDARIEGFSFDNCNIRCSEDYWNDECNKDCLRAGFQKGGQCGSPCIPCPVKCCCQK 56 Defensin-like protein 47 (Plant defensin) Q3E7C7 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00504 AEIKKFSYDHCFHLCVAGEYGSNECFVDCAQKGFWHGDCANRTEKDPIRCCCYN 54 Putative defensin-like protein 48 (Plant defensin) Q2V365 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00505 AETTKFSYDHCFHLCVEGEYGSRECFVDCTQKGFWHGVCANKTTAKDPIHCCCYN 55 Defensin-like protein 49 (Plant defensin) Q2V366 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924##14993207 Plant Physiol. 2005 Jun;138(2):600-610.##Genome Res. 2004 Mar;14(3):406-413. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Castelli V, Aury JM, Jaillon O, Wincker P, Clepet C, Menard M, Cruaud C, Qu?tier F, Scarpelli C, Sch?chter V, Temple G, Caboche M, Weissenbach J, Salanoubat M." Genome organization of more than 300 defensin-like genes in Arabidopsis.##Whole genome sequence comparisons and full-length cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation. DRAMP00506 SEIKAKINGLECFNTCTPYYDDYKCNVDCLSSGYPAGDCHIVSPSQPKKCCCY 53 Defensin-like protein 50 (Protein LCR49; Plant defensin) P82764 Belongs to the DEFL family LCR49 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17229318##11437247##15955924 BMC Genomics. 2007 Jan 17;8:18.##Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Moskal WA Jr, Wu HC, Underwood BA, Wang W, Town CD, Xiao Y.##Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Experimental validation of novel genes predicted in the un-annotated regions of the Arabidopsis genome.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00507 SEIKAKINGLECFNTCTSYYDDHKCNVDCLSSGYPAGECYTVSPSQPKKCCCY 53 Defensin-like protein 51 (Protein LCR48; Plant defensin) "P82763, A0MJW7, A7REH1" Belongs to the DEFL family LCR48 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17565583##11437247##15955924 Plant J. 2007 Jul;51(2):262-280.##Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA.##Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00508 VSGPPKCIALCRPGYYERFECFHDCITEGYDDGSCVPGPTTAKCGIITKTTNKICYSFAFE 61 Putative defensin-like protein 52 (Plant defensin) Q2V433 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "PTM: Problely contains two disulfide bonds. Caution: Could be the product of a pseudogene. Lacks 2 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00509 MFSQNICMWRDCFARCSPGYYERFECFHDCITKGYDDGNCVPGPKTGRCCCTR 53 Putative defensin-like protein 53 (Plant defensin) P0CAY2 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "PTM: Contains four disulfide bonds (By similarity). Caution: Could be the product of a pseudogene. Lacks the signal peptide, which is a conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00510 ESVIEPAKYGACLFLCDARRDDHACFYDCTNVAIYRTGHCVGNPPRCCCIRG 52 Defensin-like protein 54 (Plant defensin) Q8GY39 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11910074##15955924##14993207 Science. 2002 Apr 5;296(5565):141-145.##Plant Physiol. 2005 Jun;138(2):600-610.##Genome Res. 2004 Mar;14(3):406-413. "Seki M, Narusaka M, Kamiya A, Ishida J, Satou M, Sakurai T, Nakajima M, Enju A, Akiyama K, Oono Y, Muramatsu M, Hayashizaki Y, Kawai J, Carninci P, Itoh M, Ishii Y, Arakawa T, Shibata K, Shinagawa A, Shinozaki K.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Castelli V, Aury JM, Jaillon O, Wincker P, Clepet C, Menard M, Cruaud C, Qu?tier F, Scarpelli C, Sch?chter V, Temple G, Caboche M, Weissenbach J, Salanoubat M." Functional annotation of a full-length Arabidopsis cDNA collection.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Whole genome sequence comparisons and full-length cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation. DRAMP00511 LSNSDALASSVIETTKNDVCSTPCTIRYGTFECFQDCILDHFRDGNCINGRCCCKY 56 Putative defensin-like protein 55 (Plant defensin) Q2V2Q4 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00512 DVLASSDIYICVTVIETTKNDVCSTPCTIRYGTFECFHDCILEHYRDGNCINGRCCCK 58 Putative defensin-like protein 56 (Plant defensin) Q2V4A6 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00513 SSVIETTKNDVCSTPCTRRYGTYECWHDCLHERYNDGGCVDGRCCCKK 48 Putative defensin-like protein 57 (Plant defensin) Q2V4A8 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00514 DVLVSSVIETSKNDVCFIPCTRRYGDWECYDDCLGKNFNDGGCVDGRCCCKK 52 Defensin-like protein 58 (Plant defensin) "Q4VNZ9, F4IU82, F4IU83" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00515 LSNSDILVSSVIETSKYDVCFIPCTRRYEDRECNDDCLAKDFNDGGCVDGRCCCKY 56 Defensin-like protein 59 (Plant defensin) Q4VNZ8 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00516 EVLVAPVIETAQNDVCFVPCTSRYGHYECAFDCMHKRYKDGGCVHGRCCCKT 52 Putative defensin-like protein 60 (Plant defensin) Q2V4A5 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00517 YDRCIGPCLRFYGNHQCYKNCRKAKYDGGQCDFVKKGEKLPECCCYYNKN 50 Putative defensin-like protein 62 (Plant defensin) Q2V485 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00518 SYNIGQTRLVVIQEQEPHCIGPCEIAFGNRPCNEECTSQQYAYGFCDYQTKGEDNPQCCCYTS 63 Putative defensin-like protein 63 (Plant defensin) Q2V4G1 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00519 ERIDICFIPCTRRYGDYECWFDCTYNRYKEGGCVEDVVVKHNRNRPTFRAVELCFFSIKFMYDFSMK 67 Putative defensin-like protein 64 (Plant defensin) Q2V4A7 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Caution: Could be the product of a pseudogene. Lacks 2 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00520 FSVQIGISVQAAPPTCGRDCTEKFLTQDCDKYCVGLSYKKGVCILSEGLPPKTSTYRCCCS 61 Putative defensin-like protein 66 (Plant defensin) Q2V2Y6 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00521 VEMGISVQALPPTCGPDCTGRFMNQDCSKYCAALSYKHGVCILFRGLPPRTSTLRCCCG 59 Putative defensin-like protein 67 (Plant defensin) Q3EBU2 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00522 YDLFSEIGISAATLVIPTCFENCNATFQDPECNKWCALLAYKDGSCLYPPSEVDDLPPIKRPYIPRCCCNPITLSPPSP 79 Defensin-like protein 68 (Plant defensin) "Q2V4L5, A0MJT8, Q9LR89" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924##17147637##17229318 Plant Physiol. 2005 Jun;138(2):600-610.##Plant Biotechnol J. 2006 May;4(3):317-324.##BMC Genomics. 2007 Jan 17;8:18. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Moskal WA Jr, Wu HC, Underwood BA, Wang W, Town CD, Xiao Y." Genome organization of more than 300 defensin-like genes in Arabidopsis.##Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Experimental validation of novel genes predicted in the un-annotated regions of the Arabidopsis genome. DRAMP00523 YDLFTGIGIDARTVPPTCYESCNATFQNPECNKMCVGLAYKDGSCIYPPPEVDGLPPKRPYFPRCCCNPIILSPPSP 77 Defensin-like protein 69 (Plant defensin) "Q9FL73, A0MFP1" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9679202##15955924##17147637 DNA Res. 1998 Apr 30;5(2):131-145.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant Biotechnol J. 2006 May;4(3):317-324. "Kaneko T, Kotani H, Nakamura Y, Sato S, Asamizu E, Miyajima N, Tabata S.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P." "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations." DRAMP00524 NFASGEASSQLCFNPCTPQLGNNECNTICMNKKYKEGSCVGFGIPPTSKYCCCKT 55 Putative defensin-like protein 70 (Protein LCR83; Plant defensin) P82792 Belongs to the DEFL family LCR83 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00525 LPSSVINGFGYDYCIVECSITFLDDACKPLCIDRGYSDGGCIGLSPHFKCCCKK 54 Defensin-like protein 71 (Plant defensin) P82793 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00526 MKLSILVKAMKRNNGFRYDYCIAECSEHFLDDVCKPVCIDKGYSDGGCIGLAPNFKCCCKK 61 Putative defensin-like protein 72 (Plant defensin) Q2V2S9 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "PTM: Contains four disulfide bonds (By similarity). Caution: Could be the product of a pseudogene. Lacks the signal peptide, which is a conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00527 EPQCIGSCEMLADCNTACIRMGYLFGQCVGWKTPDMCCCNH 41 Putative defensin-like protein 73 (Protein LCR44; Plant defensin) P82759 Belongs to the DEFL family LCR44 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00528 QKECIGPCDMFTDCQAACVGIRKGYNYGQCVAWKPKDDDPFTCCCYKLTP 50 Defensin-like protein 74 (Protein LCR43; Plant defensin) P82758 Belongs to the DEFL family LCR43 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00529 ITVQADCIGPCNDDCQQLCKSKGYTDWTCASFRTKSSCCCKPPRHQIFEQNAQLNN 56 Defensin-like protein 75 (Protein LCR45; Plant defensin) P82760 Belongs to the DEFL family LCR45 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247 Plant Mol Biol. 2001 May;46(1):17-34. "Vanoosthuyse V, Miege C, Dumas C, Cock JM." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response. DRAMP00530 IDVHDAMCYRSECTSVCDQICLSHGYTNGWYCGTFRLHTGCCCLKKKELNQIISPSKN 58 Defensin-like protein 76 (Protein LCR86; Plant defensin) P82795 Belongs to the DEFL family LCR86 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10470850##11437247 DNA Res. 1999 Jun 30;6(3):183-195.##Plant Mol Biol. 2001 May;46(1):17-34. "Kaneko T, Katoh T, Sato S, Nakamura Y, Asamizu E, Kotani H, Miyajima N, Tabata S.##Vanoosthuyse V, Miege C, Dumas C, Cock JM." "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence features of the regions of 1,011,550 bp covered by seventeen P1 and TAC clones.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response." DRAMP00531 RSNGIYDPMCPGVCGNLVKPDCNGLCHELGFPAGGYCKPGNTCCCKKKDSGPVDVPPTA 59 Defensin-like protein 78 (Plant defensin) "Q9SL74, A0MJT1" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924##17565583 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants. DRAMP00532 YQMLICLDLNISCADCQKQCDETSYGGMCLNGGRTCCCKKSPPPSYYDPRPPSS 54 Putative defensin-like protein 79 (Plant defensin) Q2V470 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00533 EVRDICPGVCHAGIEPDCDTLCISMGFTGGYCQGLTCCCNPKSSKSSIINRPI 53 Putative defensin-like protein 80 (Protein LCR81; Plant defensin) P82790 Belongs to the DEFL family LCR81 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00534 KSPVSCDGACTSTPQCNKICTSKGYKKGICHGSAHLFYICCCYAKFESQYDPSISSPPNY 60 Defensin-like protein 81 (Plant defensin) Q2V4G6 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924##17565583 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants. DRAMP00535 RTQEHPCQDYRLGCKSRDVCNAKCLSLGYVKGGDCVTFAFPICCCKINFGFQDDSPISSPIFTD 64 Defensin-like protein 82 (Plant defensin) Q2V334 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14993207 Genome Res. 2004 Mar;14(3):406-413. "Castelli V, Aury JM, Jaillon O, Wincker P, Clepet C, Menard M, Cruaud C, Qu?tier F, Scarpelli C, Sch?chter V, Temple G, Caboche M, Weissenbach J, Salanoubat M." Whole genome sequence comparisons and full-length cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation. DRAMP00536 QIITCLPGECTNPSECNAACKSNGYKGGACVSMSIGSTTGACCCKPNFKSQDSFKSNDIIINNN 64 Putative defensin-like protein 83 (Protein LCR46; Plant defensin) P82761 Belongs to the DEFL family LCR46 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10470850##11437247 DNA Res. 1999 Jun 30;6(3):183-195.##Plant Mol Biol. 2001 May;46(1):17-34 "Kaneko T, Katoh T, Sato S, Nakamura Y, Asamizu E, Kotani H, Miyajima N, Tabata S.##Vanoosthuyse V, Miege C, Dumas C, Cock JM." "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence features of the regions of 1,011,550 bp covered by seventeen P1 and TAC clones.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response." DRAMP00537 QSSKCTKGCTSTPECNIKCMKKGGGHCQAYIGRSHGRLAIENYCCCNNYSNSPISSPVMN 60 Putative defensin-like protein 84 (Plant defensin) Q2V2Y3 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00538 LISDKCTEGCKSTIGCNTRCMMRGGGYCESAKIHGAVKIFCCCNNYSNSPISSPVIN 57 Defensin-like protein 85 (Plant defensin) Q8GXV6 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11910074##9628582 Science. 2002 Apr 5;296(5565):141-145.##DNA Res. 1998 Feb 28;5(1):41-54. "Seki M, Narusaka M, Kamiya A, Ishida J, Satou M, Sakurai T, Nakajima M, Enju A, Akiyama K, Oono Y, Muramatsu M, Hayashizaki Y, Kawai J, Carninci P, Itoh M, Ishii Y, Arakawa T, Shibata K, Shinagawa A, Shinozaki K.##Sato S, Kaneko T, Kotani H, Nakamura Y, Asamizu E, Miyajima N, Tabata S." "Functional annotation of a full-length Arabidopsis cDNA collection.##Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones." DRAMP00539 QFRGIKQCEMKCYSTPECNATCLHEGYEEGKCLKSWDGGVECCCLGLLASSHQDSSPISSPHYIIFHGICILNI 74 Putative defensin-like protein 86 (Protein LCR82; Plant defensin) P82791 Belongs to the DEFL family LCR82 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None PTM: Contains four disulfide bonds (By similarity). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00540 QLKSTCRIAEAWKGAKECNAKCAALGTTRGGVCQKFLGDLYCCCWD 46 Defensin-like protein 87 (Plant defensin) Q3E7S1 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Caution: Could be the product of a pseudogene. Lacks 1 of the 4 disulfide bonds, which are conserved features of the family. PTM: Contains three disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00541 VEVIPCIAGSKCTNDMTYNELCRFKGFSKGGFCQKYVHQTIGRCCCHPTGLESQESSISGDTNVVITN 68 Putative defensin-like protein 88 (Plant defensin) Q2V3J1 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00542 QTMQCYSGIACTDDGTCNDYCNPRNNNLGGVCLRRANCCCCYVSVVKSQESSLSKDTNNVFITN 64 Putative defensin-like protein 89 (Plant defensin) Q2V3J0 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00543 SPEKYYDCKQDGCITTPPCWRKCVSMGYPKGGECRIYSYGGVCCCDLTSKPPN 53 Defensin-like protein 90 (Plant defensin) Q2V4G9 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00544 FTIAEPYIHPCMKGFCSFKSECANKCIFMGHHKGGDCIGGLDGIYCCCLA 50 Defensin-like protein 91 (Protein LCR47; Plant defensin) P82762 Belongs to the DEFL family LCR47 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14993207##11437247##15955924 Genome Res. 2004 Mar;14(3):406-413.##Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Castelli V, Aury JM, Jaillon O, Wincker P, Clepet C, Menard M, Cruaud C, Qu?tier F, Scarpelli C, Sch?chter V, Temple G, Caboche M, Weissenbach J, Salanoubat M.##Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Whole genome sequence comparisons and full-length cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00545 WGKCDLRKGLCRLADTISTCDVPCRAVDSKYHGGECLNVGGGQGICWCCRDYDAAKSGAEKESM 64 Defensin-like protein 95 (Plant defensin) "Q6NMS3, O49628" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00546 RQVCDYDKGECNSYEKSSTCIEPCKQLDSKFIGGRCIPVGGITGMGLCVCCRDVQRGAEKESM 63 Defensin-like protein 96 (Plant defensin) "Q8L7G7, O49628, Q8H0Y6" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Confers broad-spectrum resistance to pathogens. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00547 RRVCDSAAGLCSMLFSCNTQCNSLGRNFTGGECSDARFPGLSVCYCCHNVESSAEMESM 59 Defensin-like protein 97 (Protein LCR85; Plant defensin) "P82794, O49626, Q1PE59" Belongs to the DEFL family LCR85 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924##17565583 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants. DRAMP00548 RLVCDTPAGTCTSSSTCNDQCNTWGGNYSGGECADSSFPGLSICYCCHYVGSSAEMESM 59 Defensin-like protein 98 (Plant defensin) "Q94AZ8, O49626" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00549 SCDFPLGACTPFRDCKESCIKFKTRAGQTFFDGKCRPRDRPSVWTACFCCYYDSIGAQ 58 Defensin-like protein 100 (Plant defensin) "Q3E6U0, A0MJT5, O49626" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924##17565583 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants. DRAMP00550 FPASDQSIYARCIGPCPRYAVPHWCENECLSRKYMAGGECAFIEGEGPTPRCCCINL 57 Putative defensin-like protein 101 (Plant defensin) Q2V337 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00551 RTTTGGSPGYGIGGRTKTCFTPALCIYRGVHGCDSYCKTKNFDYGYCRQEHCCCVNY 57 Putative defensin-like protein 102 (Plant defensin) Q2V3L0 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00552 LPTTARSPGYEIGPQRRRRVTCFSFSFCKPARGLASCDLFCKRLKFESGLCTGDLEKCCCIDYIN 65 Defensin-like protein 103 (Plant defensin) Q8GXR4 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11910074##15955924 Science. 2002 Apr 5;296(5565):141-145.##Plant Physiol. 2005 Jun;138(2):600-610. "Seki M, Narusaka M, Kamiya A, Ishida J, Satou M, Sakurai T, Nakajima M, Enju A, Akiyama K, Oono Y, Muramatsu M, Hayashizaki Y, Kawai J, Carninci P, Itoh M, Ishii Y, Arakawa T, Shibata K, Shinagawa A, Shinozaki K.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Functional annotation of a full-length Arabidopsis cDNA collection.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00553 LPMTHGGKPGYGIERTIIRPEWRCYVDEGCPKGQGAPCEKNCKNVADYGICIGIKCCCFDVIPVPPT 67 Putative defensin-like protein 104 (Plant defensin) Q2V476 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00554 MLMACYSAGQLGCLVFCNEAEYSYGKCIGRGRCCCYDL 38 Putative defensin-like protein 105 (Plant defensin) P0CAY3 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00555 HTTIASAPSSGEPTTYATGPALSKHSHDNDGICFVTPACFAPGQYEIGCIVYCHESHYKHYKCVNRSCCCYNTDKNASELK 81 Defensin-like protein 106 (Plant defensin) "Q1G3Y1, A0MDJ9, Q9SYA4" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924##17565583 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants. DRAMP00556 RMTTTTSPGFGIKQQDRQCFEHAPYLCRGGEGDCRMYCRDLDFSFGTCFSGVCCCQI 57 Defensin-like protein 107 (Plant defensin) Q2V413 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00557 RMTTASTPGYGIKQEDRLCIQGQEGTKLCSSGTSRDCLNFCLIRGYAGGSCYAYTLDQCCCRIPPPKLK 69 Defensin-like protein 108 (Protein LCR51; Plant defensin) "A8MQN0, O80684" Belongs to the DEFL family LCR51 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00558 RPSFKPIPLFGEKLTQCFDTRPCLQGMLKCIEFCSSMGTADGQCNNENLCCCTHE 55 Defensin-like protein 109 (Plant defensin) Q2V390 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9679202##15955924 DNA Res. 1998 Apr 30;5(2):131-145.##Plant Physiol. 2005 Jun;138(2):600-610. "Kaneko T, Kotani H, Nakamura Y, Sato S, Asamizu E, Miyajima N, Tabata S.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Genome organization of more than 300 defensin-like genes in Arabidopsis." DRAMP00559 RSTSDIVSGSGIKEDEHVCFKTSPCLPEVGGEKGCIAFCSRMKFTTGLCLGSVVCCCYT 59 Putative defensin-like protein 110 (Plant defensin) Q2V4N0 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00560 SDDTQGFGIKQEYKQCYTPDPCRKGGNDECERFCVAKSGLLYGKCINDGSKDVCCCLTK 59 Putative defensin-like protein 111 (Protein LCR50; Plant defensin) P82765 Belongs to the DEFL family LCR50 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00561 SDRTSGVGINQEYAKCYDLADCQKPKVDDAACERFCGAKSFLLYGKCDTATNKCCCKSKTK 61 Defensin-like protein 112 (Plant defensin) Q2V488 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00562 SDSFPGLGLKKQAHKQCYSPDLCTGGDSKCDICCVLISGVYYGKCIQSKCHCLNKTK 57 Defensin-like protein 113 (Plant defensin) Q2V342 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00563 SELDNTSGFEIKQEDKCYGPEPCKNGYEGCLFFCVRIAYYLYGECTMKPDHQKHCCCVTK 60 Putative defensin-like protein 114 (Plant defensin) Q2V322 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00564 SDSTLGIGINQDWKKCFSPDPCKKAGTQGCMEFCRTISFLLFGECTSKPDQCCCVTK 57 Defensin-like protein 115 (Plant defensin) Q2V321 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00565 SDSALGIGIKEDWEVCFSIDPCLTGEGTLGCTKWCRNHINLSLVGYCRTDPEHCCCVAEK 60 Defensin-like protein 116 (Plant defensin) Q3E8I8 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9679202##15955924##14993207 DNA Res. 1998 Apr 30;5(2):131-145.##Plant Physiol. 2005 Jun;138(2):600-610.##Genome Res. 2004 Mar;14(3):406-413. "Kaneko T, Kotani H, Nakamura Y, Sato S, Asamizu E, Miyajima N, Tabata S.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Castelli V, Aury JM, Jaillon O, Wincker P, Clepet C, Menard M, Cruaud C, Qu?tier F, Scarpelli C, Sch?chter V, Temple G, Caboche M, Weissenbach J, Salanoubat M." "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Whole genome sequence comparisons and full-length cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation." DRAMP00566 SDGTSGYGITEATKRCFTPAPCTRGLFYCQTFCSSLSAVLIGVCESGICCCILNQ 55 Defensin-like protein 117 (Plant defensin) Q2V4G3 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924##17565583 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants. DRAMP00567 QEMCRDILMKAKNCDEGTCDTLCKQKWKGNGSCFPNVYTYRKSCLCTFPCKT 52 Putative defensin-like protein 118 (Protein LCR52; Plant defensin) P82766 Belongs to the DEFL family LCR52 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00568 QEMCRDLLMRAKNCDDSTCATLCKQKWKGNGSCFPNVYRKSCLCTFPCKT 50 Putative defensin-like protein 119 (Protein LCR53; Plant defensin) P82767 Belongs to the DEFL family LCR53 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00569 QEMCHDLIKKTDCDDATCVTLCKQKWNGNGGGSCFQIVNLKSCLCAFPCQV 51 Putative defensin-like protein 120 (Protein LCR56; Plant defensin) P82770 Belongs to the DEFL family LCR56 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00570 QETCHDLIMKRDCDEATCVNMCQQKWKGSGGSCFQNFNVMSCICNFPCQV 50 Putative defensin-like protein 121 (Protein LCR55; Plant defensin) P82769 Belongs to the DEFL family LCR55 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00571 QELCHDYMSGTELCEEDKCVAKCIWMHGTAAKGTCMPKPSKQCVCTYSCNA 51 Defensin-like protein 122 (Protein LCR30; Plant defensin) P82745 Belongs to the DEFL family LCR30 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. Tissue specificity: Expressed in flower buds, but not in stems, roots or rosette leaves. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00572 MRPRSRAGDKFMSQGQELCHEYFQLTAPCEKQPCIDMCSSKYKTGKGVCGPAVHQCFCTFSCTV 64 Defensin-like protein 123 (Plant defensin; Uncertain) Q0WN71 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924##17565583 Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants. DRAMP00573 ANCVNYFEITFPEVCEANWCAAECLKAYKNGKGTCWQKFCQCVYDC 46 Defensin-like protein 124 (Protein LCR16; Plant defensin) "P82731, A0MJV4" Belongs to the DEFL family LCR16 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924##17565583 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants. DRAMP00574 EEKQCYDYLLTPQENCEGLICAHECTMQHGGNGVCVDTTSTVCICTYDCTS 51 Defensin-like protein 125 (Protein LCR54; Plant defensin) P82768 Belongs to the DEFL family LCR54 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00575 QHAMCHEILPETDCGAGSCTALCLQLWRGTGKCVRTNDQKLICLCNFECIV 51 Putative defensin-like protein 126 (Protein LCR6; Plant defensin) P82721 Belongs to the DEFL family LCR6 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9679202##11437247##15955924 DNA Res. 1998 Apr 30;5(2):131-145.##Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis." DRAMP00576 QNAICQKFLSETDCGAGSCTALCLQLWKGIGKCIKTDDHKLLCLCKYECIV 51 Defensin-like protein 127 (Protein LCR20; Plant defensin) "P82734, Q4VP05, Q4VP06" Belongs to the DEFL family LCR20 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9679202##11437247##15955924 DNA Res. 1998 Apr 30;5(2):131-145.##Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis." DRAMP00577 QHICHQILLNNNCDGATCTSLCDKQLQGTGQCYKTVDKRFICLCNYLCRT 50 Putative defensin-like protein 128 (Protein LCR8; Plant defensin) P82723 Belongs to the DEFL family LCR8 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00578 DTCHEYLYPEKCENNQCNSECATKFKEVGVFGFCVPPRSEPTEQFCICSYNC 52 Putative defensin-like protein 129 (Protein LCR13; Plant defensin) P82728 Belongs to the DEFL family LCR13 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00579 SIFIKYSDRTCHVYIKAENCEIDQCNWECGTKYKRVGVQGLCVPPGFDPIDQACLCSFNC 60 Defensin-like protein 130 (Protein LCR28; Plant defensin) "P82743, Q2V320" Belongs to the DEFL family LCR28 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9679202##11437247##15955924 DNA Res. 1998 Apr 30;5(2):131-145.##Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis." DRAMP00580 HICHDYLEGDHCDPKDCNLDCRDKWKGTGTCEPPTGTPLTRTCYCTYDC 49 Putative defensin-like protein 131 (Protein LCR29; Plant defensin) P82744 Belongs to the DEFL family LCR29 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00581 NDEQLRGNRCFQIKFKTGKCVPKECQTACQEKLRKPKLKGEGFCMKECTCCFYT 54 Putative defensin-like protein 133 (Protein LCR33; Plant defensin) P82748 Belongs to the DEFL family LCR33 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00582 FSPEDCLDDVGWILICTKPTCKFSCWTSRSVNKGRKMQDYWCSDSNTCHCVFCTGD 56 Putative defensin-like protein 134 (Plant defensin) P0CAY4 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00583 QRRKCDEKIVLQFCNGRNRCYEYCDTKECVAACKKKRNGEGICNGDVFSVSAQCLCLYKC 60 Putative defensin-like protein 135 (Plant defensin) Q2V3K1 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00584 NMSVDQKRCWATLKENNCVHDECRSMCLKKNPKGHGRCIKSSKGRIICLCGYDCP 55 Putative defensin-like protein 137 (Protein LCR14; Plant defensin) P82729 Belongs to the DEFL family LCR14 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00585 QPLGTMERCYDMLTWGECVPDNCAFSCALKRHGKGGCIKAYDNRPACVCYYTCLRS 56 Putative defensin-like protein 139 (Protein LCR7; Plant defensin) P82722 Belongs to the DEFL family LCR7 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00586 QPLEEMVECKEVLWPEECKYDACAFACALKRHGKGGCLEGPDYRSACICQYACKRS 56 Defensin-like protein 140 (Protein LCR15; Plant defensin) P82730 Belongs to the DEFL family LCR15 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00587 QQQQQRCEEALTEIDCGAGNCNALCLQKRKGLGRCVQRTPCDKLKCMCYYPCSS 54 Defensin-like protein 141 (Protein LCR3; Plant defensin) P82718 Belongs to the DEFL family LCR3 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9679202##11437247##15955924 DNA Res. 1998 Apr 30;5(2):131-145.##Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis." DRAMP00588 EKLTTCSRFLSQKSGKCVKEDCDRMCKQKWPGKYTVGHCYGQFKDAKRCLCSVCGPDRQPP 61 Putative defensin-like protein 142 (Protein LCR34; Plant defensin) P82749 Belongs to the DEFL family LCR34 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00589 MVNGQCSFPQPVGPNGKCVPKDCKSLCHKKYKGGSICTTGKPNICMCLVCRRRSPEV 57 Defensin-like protein 144 (Protein LCR10; Plant defensin) "Q8S8H9, A0MJT0, P82725, Q1PF66" Belongs to the DEFL family LCR10 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17147637##15955924##17565583##11437247 Plant Biotechnol J. 2006 May;4(3):317-324.##Plant Physiol. 2005 Jun;138(2):600-610.##Plant J. 2007 Jul;51(2):262-280.##Plant Mol Biol. 2001 May;46(1):17-34. "Underwood BA, Vanderhaeghen R, Whitford R, Town CD, Hilson P.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Silverstein KA, Moskal WA Jr, Wu HC, Underwood BA, Graham MA, Town CD, VandenBosch KA.##Vanoosthuyse V, Miege C, Dumas C, Cock JM." Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants.##Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response. DRAMP00590 NLQQRRQMNQTWCSRPLLTHKQTGKCVIEDCESKCRQKWKGNGTQATCRNQCNCHFRCPWIQGQP 65 Putative defensin-like protein 145 (Protein LCR2; Plant defensin) P82717 Belongs to the DEFL family LCR2 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00591 NVQQVKREQCHTVIPNKSGKCIFTECKSACEKLKKPVASLCLPPKTCRCYHFCS 54 Putative defensin-like protein 146 (Protein LCR9; Plant defensin) P82724 Belongs to the DEFL family LCR9 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00592 NVQQKRSNRCIDFPVNPKTGLCVLKDCESVCKKTSKGLEGICWKFNAKGKDPKQCKCCGLWPPLY 65 Defensin-like protein 147 (Protein LCR1; Plant defensin) P82716 Belongs to the DEFL family LCR1 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00593 NVEQKSQDWCWSIVNKDRCLQKECESLCSKKHPKGKFMCIPSTPGGPFQCHCRHPCR 57 Putative defensin-like protein 148 (Protein LCR4; Plant defensin) P82719 Belongs to the DEFL family LCR4 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00594 NEGLGKPKKQCNEILKQSNCVAAECDSMCVKKRGKGAGYCSPSKKCYCYYHCP 53 Defensin-like protein 149 (Protein LCR5; Plant defensin) "Q8S8H3, P82720, Q8LGD4" Belongs to the DEFL family LCR5 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00595 DVDQGYKQQCYKTIDVNLCVTGECKKMCVRRFKQAAGMCIKSVPSAPAPNRCRCIYHC 58 Putative defensin-like protein 150 (Protein LCR32; Plant defensin) P82747 Belongs to the DEFL family LCR32 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00596 QAPSTCFEALKDASKGASCDSELCASLCKKKSGGGVGTCRTKTTQPSKGQPECHCRFWCKSDGTPYK 67 Defensin-like protein 151 (Protein LCR17; Plant defensin) "Q9T0E3, Q6GKX9" Belongs to the DEFL family LCR17 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00597 KQRLCIKVLTNASHVSKGASTCDSKLCTSLCEKISPQGVSFCKPIATTGQSKKGNPVCNCRYWCRSDGTPHTT 73 Putative defensin-like protein 152 (Protein LCR11; Plant defensin) P82726 Belongs to the DEFL family LCR11 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00598 KVPCLSRMFNKNNTCSFLRCEANCARKYKGYGDCRPGDRPHDKKDSLFCFCNYPC 55 Defensin-like protein 153 (Protein LCR31; Plant defensin) "P82746, A0MJV0" Belongs to the DEFL family LCR31 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00599 VVEKAKGDGSCTIIIDPKAPSCDIIQCRLSCITDYNGLAECIASRIGSPPNCVCTYDC 58 Putative defensin-like protein 154 (Protein LCR35; Plant defensin) P82750 Belongs to the DEFL family LCR35 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00600 DKRCSIIIDLSPCYPIECRLSCITERNGDGECVVSKVGSTPNCLCTYDC 49 Defensin-like protein 155 (Protein LCR36; Plant defensin) P82751 Belongs to the DEFL family LCR36 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00601 KRHCSTIILPESPCVPQDCVEYCFEEYNGGGTCIASKTGRTTNCMCTYNCHGNNL 55 Defensin-like protein 156 (Protein LCR21; Plant defensin) P82735 Belongs to the DEFL family LCR21 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00602 DERCTIIIHPGSPCDPSDCVQYCYAEYNGVGKCIASKPGRSANCMCTYNC 50 Putative defensin-like protein 157 (Protein LCR22; Plant defensin) Q9M0F3 Belongs to the DEFL family LCR22 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00603 DQTDKYCTIIIDPRTPCDLVDCRLSCYTGYNGVGKCIASKASRTPNCVCTYNC 53 Putative defensin-like protein 158 (Protein LCR23; Plant defensin) P82737 Belongs to the DEFL family LCR23 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00604 KRCHLTIDKATACSLSDCRLSCYSGYNGVGKCFDDPKVAGPSNCGCIYNC 50 Defensin-like protein 159 (Protein LCR25; Plant defensin) "P82739, A0MJW9" Belongs to the DEFL family LCR25 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00605 DEGKRCHTTIDKGNFCDLVDCRLSCFSGYNGVGKCFDDPKVPGRSNCGCLYNC 53 Putative defensin-like protein 160 (Protein LCR26; Plant defensin) Q9M0F2 Belongs to the DEFL family LCR26 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00606 EECRLTIDKATPCHLSDCRLSCYTGYNGVGECFDDPNVPGPDNCGCRYNC 50 Defensin-like protein 161 (Protein LCR27; Plant defensin) Q9M0F1 Belongs to the DEFL family LCR27 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00607 GATIKKCVVDVKLSKPCTFQECQPLCLQKYNGNGLCPGDDNNICACVYNC 50 Putative defensin-like protein 162 (Protein LCR37; Plant defensin) P82752 Belongs to the DEFL family LCR37 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00608 ADIKRCVVDVKLSKPCTFQECIPLCFQRYNGNGVCTGKKNEICTCAYNC 49 Defensin-like protein 163 (Protein LCR24; Plant defensin) "Q8LFM0, P82738, Q0V821" Belongs to the DEFL family LCR24 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00609 KQLKTCTSVIKLGHPCDIESCLNECFRVYNTGFATCRGDKYSQLCTCEYNC 51 Defensin-like protein 164 (Protein LCR38; Plant defensin) P82753 Belongs to the DEFL family LCR38 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00610 QKRCRQELEPGKQCVLAKCRELCFKQLKGFGSCIEKPPGSSKYTCNCFYNCGPPGFF 57 Putative defensin-like protein 165 (Protein LCR12; Plant defensin) P82727 Belongs to the DEFL family LCR12 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00611 LYMCVSSTCVIQWCAIQCKRKEANGIGTCKPRPNQGKIQYRKLKEECHCVYKCS 54 Defensin-like protein 166 (Plant defensin) P0CAY5 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00612 RNRICRTSEKYYREFCGHAGNDDCLSKSTKKPKPFKCVCHDNRSQNITSINDRYNNCICTFYC 63 Putative defensin-like protein 168 (Plant defensin) Q2V3Q1 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00613 LMDSMPQRHPVEGWCKRPLPNQKPGPCNNDRCSARCKEQKQFEFKGGKAMGICSSENRCLCTFRCR 66 Putative defensin-like protein 169 (Plant defensin) Q2V3K0 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00614 NMGCMAVLGSCGVITDCSGSCKTKFGQDASGDCDRDGGQGTCMCGYPCPHDKLHM 55 Putative defensin-like protein 170 (Protein LCR62; Plant defensin) P82776 Belongs to the DEFL family LCR62 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00615 NMGCMAVLGSCGVITDCSGECISRFGPQARGYCDRDGGSGTCVCVYPCPADKPHM 55 Defensin-like protein 171 (Protein LCR61; Plant defensin) "P82775, Q4VNZ4" Belongs to the DEFL family LCR61 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00616 NMGCTATMGPCEKDKSCSATCRATFGDRANGFCDYSTSTSPGGECTCVYHCPPVVPHESHL 61 Defensin-like protein 172 (Protein LCR60; Plant defensin) P82774 Belongs to the DEFL family LCR60 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00617 NMGCIQIIGRCIKIPDCSASCRKFLGPHASGYCDNDGAGGTCICTYPCQTKEIHM 55 Defensin-like protein 173 (Protein LCR63; Plant defensin) "P82777, Q4VNZ3" Belongs to the DEFL family LCR63 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00618 NTGCFDYDVYQPCDHCRERCLKYYPVTRKAICRKNHCVCIGPCPNDKAIPNVKLFKNVKEQILS 64 Defensin-like protein 175 (Plant defensin) Q2V4H7 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00619 NTGCFDYDVYQPCDHCRERCLKYYPVTRKAICRKNHCVCIGPCPDDKAIPDVKLFKNVKEQILS 64 Defensin-like protein 176 (Protein LCR65; Plant defensin) "P82779, A0MJW1" Belongs to the DEFL family LCR65 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00620 NMGCNDYIVGDVCVHCRERCLRYYPVTRKAECYRNHCLCIGPCPDDRPHKRFQMLNSSKNVKAQILS 67 Defensin-like protein 178 (Protein LCR64; Plant defensin) "P82778, A0MJW0" Belongs to the DEFL family LCR64 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00621 QTCDENLSSCENCDQRCKAKHGPSSVSKCNGPDGTCGCASFKPAKLCIGATDMCTDKCPTSCCDRQCAIKYKNGKGGCVDYAGYRMCICEYTC 93 Putative defensin-like protein 179 (Protein LCR57; Plant defensin) P82771 Belongs to the DEFL family LCR57 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains seven disulfide bonds (By similarity). Caution: Contains 7 disulfide bonds instead of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00622 SICNDRLGLCDGCDQRCKAKHGPSCESKCDGPVGMLLCTCTYECGPTKLCNGGLGNCGESCNEQCCDRNCAQRYNGGHGYCNTLDDFSLCLCKYPC 96 Defensin-like protein 181 (Protein LCR80; Plant defensin 3.1; Plant defensin) "P82789, A0MJT6, Q1PDQ7" Belongs to the DEFL family PDF3.1 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Confers broad-spectrum resistance to pathogens. PTM: Contains eight disulfide bonds (By similarity). Caution: Contains 8 disulfide bonds instead of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00623 NTCIEGIGNCQQCDVRCKARHGPAAKGACDSKFQLCTCNYPCGQGPSPPQPKKCYGGAGICSDRCGAQCCNQNCAQKYNQGSGFCDSIGNTSLCKCQYNC 100 Defensin-like protein 183 (Protein LCR19; Plant defensin) "P82733, Q4VNZ2" Belongs to the DEFL family LCR19 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains eight disulfide bonds (By similarity). Caution: Contains 8 disulfide bonds instead of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00624 NKKMVGEAKKCDQTWTCEGEDKCREKCLTLHNGVGVCDLYTAPLVPKQCFCHYDC 55 Putative defensin-like protein 184 (Protein LCR18; Plant defensin) P82732 Belongs to the DEFL family LCR18 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00625 KTCSDGWTCLGPKEEDKCKENCMAKHKGVGTCNLYTIPEFPAPITYYMCDCMFDC 55 Putative defensin-like protein 185 (Protein LCR39; Plant defensin) P82754 Belongs to the DEFL family LCR39 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00626 KTCSDGWTCVGEDKCKVNCMAKHKGVGTCTLYIIPSFPAPITSYICDCMFDC 52 Putative defensin-like protein 186 (Protein LCR40; Plant defensin) P82755 Belongs to the DEFL family LCR40 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00627 ENQKMVGEAKQCKTGWACFGEDACKEKCMAKYKGVGTVTYFPFPPETIIIYCECLYDC 58 Putative defensin-like protein 187 (Protein LCR42; Plant defensin) P82757 Belongs to the DEFL family LCR42 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Could be the product of a pseudogene. Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00628 ENGIMIGEAKKCSNSWICEGDEKCKEKCMADYKGNGTCYYPSPPSKQHPEFFYPTCWCGFDC 62 Putative defensin-like protein 188 (Protein LCR41; Plant defensin) P82756 Belongs to the DEFL family LCR41 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00629 MSNGMPRTVPCIEGRILWNRTLPCSSILCGDHCVPHGYRAGTCDIVNDRAICKCSRCR 58 Putative defensin-like protein 189 (Plant defensin) Q2V468 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00630 MRMTQKVSCIEGRTLWARPPKFFYCSSTLCEDNCINTGAYRGGTCDMEDEVAICRCHRCKKII 63 Putative defensin-like protein 190 (Plant defensin) Q2V467 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00631 KKPPCLEGRTAYVSPGPCSNSLCTQDCRPAGYHTGKCKVEWSTPICKCYGCRKV 54 Putative defensin-like protein 191 (Plant defensin) Q2V466 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00632 YDRKCLKEYGGDVGFSYCAPRIFPTFCDQNCRKNKGAKGGVCRWEENNAIGVKCLCNFCSEEPSDQTLSRI 71 Defensin-like protein 192 (Trypsin inhibitor ATTI-7; Plant defensin) "Q42330, Q9SX84" Belongs to the DEFL family O22866 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00633 QGSKCLKEYGGNVGFSYCAPRIFPSFCYRNCRKNKGAKGGRCRSGGAGAGSMICLCDYCSDKP 63 Defensin-like protein 193 (Trypsin inhibitor ATTI-2; Plant defensin) "O22866, Q67YC6, Q6ZZT9" Belongs to the DEFL family ATTI2 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00634 KDKECLKGYIDAPLSYCMARIYPSLCYRNCRFYKGAKGGKCDGLKCFCDFCSDKPF 56 Defensin-like protein 194 (Trypsin inhibitor ATTI-3; Plant defensin) "O22867, B9DGH7, F4IR67, Q6ZZP9, Q6ZZQ4, Q6ZZQ9, Q6ZZR4, Q6ZZR9, Q6ZZT8" Belongs to the DEFL family ATTI3 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00635 QGNECLKEYGGDVGFGFCAPRIFPTICYTRCRENKGAKGGRCRWGQGSNVKCLCDFCDDTPQ 62 Defensin-like protein 195 (Trypsin inhibitor ATTI-1; diDi 4T-1; Plant defensin) "Q42328, O22865, Q6ZZP6" Belongs to the DEFL family ATTI1 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Protein level Combine helix and strand structure "The protein contains one alpha-helix and two strands of antiparallel beta-sheet, with a type IV beta-turn connecting the two strands. The alpha-helix and the inhibitory loop are connected to the beta-sheet through three disulfide bridges; a fourth disulfide bridge connects the N- and C-termini. (Ref.3)" 1JXC resolved by NMR. "Function: Defense response to fungus. PTM: Contains four disulfide bonds." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924##12369816 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610.##Biochemistry. 2002 Oct 15;41(41):12284-96. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA.##Zhao Q, Chae YK, Markley JL." "Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis.##NMR solution structure of ATTp, an Arabidopsis thaliana trypsin inhibitor." DRAMP00636 HDSECLKEYGGDVGFGFCAPKIFPTICYRNCQKDKGANGGKCLWGEGGKVKCLCDFCSNESFNQFISLT 69 Defensin-like protein 196 (Trypsin inhibitor ATTI-4; Plant defensin) "Q8RYE7, Q6ZZS3" Belongs to the DEFL family ATTI4 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00637 KDDKFICVVEYGGDVGPTFCNPKFFPTLCRQNCRSFKGAKGGKCVKQPKHKHIKCFCDYCKDD 63 Defensin-like protein 197 (Trypsin inhibitor ATTI-6; Plant defensin) "O22869, F4IR70, Q6ZZS7, Q6ZZU1, Q8GWN0" Belongs to the DEFL family ATTI6 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity). Caution: Was initially thought (PubMed:15082560) to be a protease inhibitor." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00638 RTTTSGYGMLFDSVACEGGFEYCPRGGGNDKCTTFCRSLPNKYDFGVCDKIYACCCHINV 60 Defensin-like protein 199 (Plant defensin) Q2V4G5 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00639 RETRMMEQTCPVFWPMVPCDANKCEQMCRDYYGSVPSYCNRIGTPIAECACSLTPC 56 Defensin-like protein 201 (Plant defensin) Q2V4N2 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00640 KTCKLFRGECPVDPCEPEKCDECCKATFGKQICGKCEQESTELHCHCRR 49 Putative defensin-like protein 202 (Plant defensin) Q2V3J6 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00641 QTCFKGEAQEGVCVKVDGSKLCDLLCRATNTTWFGACEVEDNETHCHCYGPC 52 Putative defensin-like protein 203 (Plant defensin) Q2V424 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00642 HCDHFLGEAPVYPCKEKACKSVCKEHYHHACKGECEYHGREVHCHCYGDYH 51 Defensin-like protein 204 (Plant defensin) Q56XB0 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00643 NCDTYLGEVTVYYPCRERDCEAQCYEHYPHSCKGECEHHDHVVHHDNEEEHCHCYGR 57 Defensin-like protein 205 (His-rich; Plant defensin) Q9M9M3 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00644 ACFTFLGECGPEPFTGSNADCLACCVALYKSPPVCAGRVEGVPAHCHCYKS 51 Defensin-like protein 206 (Plant defensin) "Q94JR6, Q9M1Y2" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00646 ACFKFLGECGAVPFPGTNADCTSCCVGNFGSAVCAGRVEVEGGVKHCHCYGTS 53 Defensin-like protein 208 (Plant defensin) Q2V2Q8 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00647 IITKTMNSKETIYLDNPAVSPSIDQNLVDIHLGHSFVQGVMSFCYDCGKACFRRGKNLARCQKFVCRCTISKLR 74 Defensin-like protein 209 (Plant defensin) Q2V3K2 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00648 IITKTMNSKETTYLDSPAVSPSIDQYLVDIHLGHSFLQGVMSFCYDCGKACFRRGKNLARCKKFVCRCTKSGIK 74 Defensin-like protein 210 (Plant defensin) Q2V3K4 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00649 IVMKSSNSKERTYPVTPALNPLTGQHSLRQRQLIFCDECANACFRRKKPVRSCQRFICRCAIRDVGY 67 Putative defensin-like protein 211 (Plant defensin) Q2V3K7 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00650 VLINGSSDEERTYSFSPRASPFDPRSLNQELKIGRIGYCFDCARACMRRGKYIRTCSFERKLCRYSISDIK 71 Defensin-like protein 212 (Plant defensin) A8MRC6 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Defense response to fungus. PTM: Contains two disulfide bonds (By similarity). Caution: Could be the product of a pseudogene. Lacks 2 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00651 TLINGSSDEERTYSFSPTTSPFDPRSLNQELKIGRIGYCFDCARACMRRGKYIRTCSFERKLCRCSISDIK 71 Defensin-like protein 213 (Plant defensin) "Q4VP08, Q9LSW1" Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00652 ILINESSDEERTYSFSPTTSPFDPRSLNQELKIGRIGYCFDCARACMRRGKYIRTCSFERKLCRCSISGIK 71 Defensin-like protein 214 (Plant defensin) Q4VP10 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00653 ILINESSDEQRIYSFSPTTSPFDPRSLNQELKIGRIGYCFDCARACMRRGKYIRTCSFERKLCRCSISGIK 71 Defensin-like protein 215 (Plant defensin) Q4VP07 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00654 ILINESSDEQRIYSFSPTTSPFDPRSLNQELKIGRIGYCFDCARACMRRGKYIRTCSFERKLCRCSISDIK 71 Defensin-like protein 216 (Plant defensin) P0CAY6 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00655 ILIKESSEEERIYPFNPVASPFDPRSLNQILKIGKIGYCFDCARACMRRDRYIRTCSFERKLCRCSYSHIHHTHG 75 Defensin-like protein 217 (Plant defensin) Q4VP09 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00656 KNKKVVIIPGPKGERPDIKVVEGPSTVEDDFCYDCVRRCMVKGVGFYFRSCKGFVCRCYYPFMGGYGP 68 Defensin-like protein 218 (Plant defensin) Q2V370 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00657 FFKKLFLRASNIMIKSISEGKSQFSGPALSPNIDPADEHIGHSPEDMKIIFCQQCAFHCIEKKKNIAHCENSICRCTLEDIL 82 Defensin-like protein 219 (Plant defensin) Q2V305 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00658 NIMTKSISQVKSQFFSPALSPNVDPADEHIGHSPDDMKIIFCQQCAFHCIEKKKNIGNCENSICRCTLEDIL 72 Defensin-like protein 220 (Plant defensin) Q2V304 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00659 NIMTKSILEGKTQFSIPSLSSTIDPAYEHIGHFPDDMKIIFCQQCAFHCIEKKKNIPHCENSICRCTLENIL 72 Putative defensin-like protein 221 (Plant defensin) Q2V306 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00660 TVKSYSEEKTHSFDLTANPPIDLNIVDELPRDEHLGVSHADNVIGFCQECAHHCLQRKRVLGECRWFTCHCSRITIGVGL 80 Defensin-like protein 222 (Plant defensin) Q2V300 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00661 VVPSSFKRVEGPVTAASADFCYKCSRGCYRRYRRPVFCQGSICRCSSFIDDGY 53 Defensin-like protein 223 (Plant defensin) Q2V369 Belongs to the DEFL family Not found Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00662 MKKFGCNTTHPFPGKCGNNGKSSWVSDMKKLPSAPKNRDIRCECSDRPSLARGMPGERVCRCDYDC 66 Putative defensin-like protein 225 (Protein SCRL1; SCR-like protein 1; Plant defensin) P82620 Belongs to the DEFL family SCRL1 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Not found Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Could be the product of a pseudogene. Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00663 KTKWGCDMNRPFPGKCGTNGKDTCISDIKKMPGAPKDLVVRCECSQRFVWKGYPPERLCKCQYDC 65 Defensin-like protein 226 (Protein SCRL2; SCR-like protein 2; Plant defensin) P82621 Belongs to the DEFL family SCRL2 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00664 IHVEQAGVCEFTGEFPGKCGNNGRKMCVEAMNKKNKGSPGENKKNLRCECFDNPVVILGRPKRICRCRNNC 71 Putative defensin-like protein 227 (Protein SCRL28; SCR-like protein 28; Plant defensin) P82647 Belongs to the DEFL family SCRL28 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15955924 Plant Physiol. 2005 Jun;138(2):600-610. "Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00665 ANKRCHLNQMFTGKCGNDGNKACLGDFKNKRFRYDLCQCTDATQISPSLPPQRVCNCSRPC 61 Putative defensin-like protein 228 (Protein SCRL3; SCR-like protein 3; Plant defensin) P82622 Belongs to the DEFL family SCRL3 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00666 HVREVKSVETKAKRVKKVCEKAQVFEQNCGWDGNKTCIRGFNKIKEYPFHCECGIYDAPNSRRICKCKFPYSPC 74 Defensin-like protein 229 (Protein SCRL27; SCR-like protein 27; Plant defensin) P82646 Belongs to the DEFL family SCRL27 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity). Tissue specificity: Flower buds. " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00667 EKLCTTIGDLDGKCSQDGEKLCMRYMTDQSKKKFLSCTCNNVVMLHKYKHYCECQSHCTPKQT 63 Putative defensin-like protein 230 (Protein SCRL24; SCR-like protein 24; Plant defensin) P82643 Belongs to the DEFL family SCRL24 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00668 KELCNRIEDIDGNCDFEGEKGCLKFMTNKYKKERHVSCTCTNLYMLHKTKRFCDCKHRCSG 61 Putative defensin-like protein 231 (Protein SCRL25; SCR-like protein 25; Plant defensin) P82644 Belongs to the DEFL family SCRL25 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00669 GAPPVECWSEILFSGKCGFHGKKKCYKEMESKLKQRVLKCRCEDVKKDSNTSKDEHYCGCQRENPYECN 69 Defensin-like protein 232 (Protein SCRL23; SCR-like protein 23; Plant defensin) P82642 Belongs to the DEFL family SCRL23 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity). Tissue specificity: Flower buds." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00670 GAPPQDCWNLVTFPAKCGIHGKKKCFKEMESKYQQRFLQCTCKNLKPEPKSPKDEHDCTCQRANPYECNS 70 Putative defensin-like protein 233 (Protein SCRL22; SCR-like protein 22; Plant defensin) P82641 Belongs to the DEFL family SCRL22 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Transcript level Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity). Tissue specificity: Expressed at least in stem, root, rosette leaves and flower buds." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00671 VLKPMDQCGRKDIFLGGCGSNGSKTCINDFVKKGGVAAKPSSCECDDFGEEHLCRCYVPC 60 Putative defensin-like protein 234 (Protein SCRL14; SCR-like protein 14; Plant defensin) P82633 Belongs to the DEFL family SCRL14 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00672 GLDPMAANLRVRKDIFIGGCGRDGNKTCMKDFVKKGGVMNKPISCECDNLGYEHLCRCNFS 61 Putative defensin-like protein 235 (Protein SCRL26; SCR-like protein 26; Plant defensin) P82645 Belongs to the DEFL family SCRL26 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: Defense response to fungus. PTM: Contains three disulfide bonds (By similarity). Caution: Lacks 1 of the 4 disulfide bonds, which are conserved features of the family." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00673 QGKKKPPCPLGLSANGKCGHDGPKLCFSEMERKFNKDVVKTITHCKCWDDRRNNVDKHRCTCYLKHGFPCTNG 73 Putative defensin-like protein 236 (Protein SCRL20; SCR-like protein 20; Plant defensin) P82639 Belongs to the DEFL family SCRL20 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00674 QAKKKRCPIGLHTYGKCGTDRAKFCFSEIESKLSFSKQVLNTISSCRCDDDRQGNKDLYWCQCDRREGRPCPAN 74 Putative defensin-like protein 237 (Protein SCRL21; SCR-like protein 21; Plant defensin) "P82640, F4JMF8" Belongs to the DEFL family SCRL21 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00675 QVKPTGCQGGQRYRGKCGTNGTKTCVKDMMLPKLFKTKRCDCQDMLGTFKGWHFCTCYSGRPGC 64 Putative defensin-like protein 238 (Protein SCRL16; SCR-like protein 16; Plant defensin) P82635 Belongs to the DEFL family SCRL16 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11437247##15955924 Plant Mol Biol. 2001 May;46(1):17-34.##Plant Physiol. 2005 Jun;138(2):600-610. "Vanoosthuyse V, Miege C, Dumas C, Cock JM.##Silverstein KA, Graham MA, Paape TD, VandenBosch KA." Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.##Genome organization of more than 300 defensin-like genes in Arabidopsis. DRAMP00676 GLIRECDYTMEGYGPCGPNGRSLCLDTFWKTPPSPGLSKNLEGCRCEDRGKRPPIFTGLSHTCRCCWSYGGGSDD 75 Putative defensin-like protein 239 (Protein SCRL17; SCR-like protein 17; Plant defensin) P82636 Belongs to the DEFL family SCRL17 Arabidopsis thaliana (Mouse-ear cress) "Antimicrobial, Antifungal" Homology Not found Not found None "Function: May have antifungal activity. PTM: Contains four disulfide bonds (By similarity)." No MICs found in DRAMP dat