DRAMP_ID Sequence Sequence_Length Name Swiss_Prot_Entry Family Gene Source Activity Protein_existence Structure Structure_Description PDB_ID Comments Target_Organism Hemolytic_activity Linear/Cyclic/Branched N-terminal_Modification C-terminal_Modification Other_Modifications Stereochemistry Cytotoxicity Binding_Traget Pubmed_ID Reference Author Title DRAMP00856 GLPVCGETCVGGTCNTPGCTCSWPVCTRN 29 Kalata-B1 (Plant defensin) P56254 Belongs to the cyclotide family OAK1 Oldenlandia affinis "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Beta strand (3 strands; 7 residues) Not found 2KHB resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans. Active against the Gram-positive S. aureus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. Inhibitory effect on the growth and development of larvae from H. punctigera. The unmodified form has hemolytic activity, the oxidized form lacks hemolytic activity. If the protein is linearized, hemolytic activity is lost. MOA: a small number of cyclotides bind to the membrane surface and then insert first into the outer membrane leaflet followed by penetration through the membrane and pore formation. At higher concentrations of cyclotides, destabilization of membranes occurs. Tissue specificity: Leaves and stems. Lower in roots. Pharmaceutical use: The uteroactive properties of Kalata have been discovered by African traditional medicine. It is used as an ingredient of a herbal tea to accelerate childbirth. PTM: Kalata-B1 is a cyclic peptide which contains three disulfide bonds 5-19; 11-21; 14-26." "[Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.26 ?M), Micrococcus luteus (MIC=40.4 ?M);##Gram-negative bacterium: Klebsiella oxytoca (MIC=54.8 ?M);##Fungi: Candida kefyr (MIC=21.4 ?M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=140 nM)." [Ref.12779323] HD50 = 300 M against Human type A red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.7703226] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys26." L [Ref.18008336]CEM-SS cells:IC50=3500 nM. Cell membrance 18008336##10430870##7703226##17534989##23129773 Biopolymers. 2008;90(1):51-60.##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biochemistry. 1995 Apr 4;34(13):4147-4158.##Chembiochem. 2007 Jun 18;8(9):1001-1011.##J Biol Chem. 2012 Dec 21;287(52):43884-98. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Tam JP, Lu YA, Yang JL, Chiu KW.##Saether O, Craik DJ, Campbell ID, Sletten K, Juul J, Norman DG.##Plan MR, G?ransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.##Wang CK, Wacklin HP, Craik DJ." "Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.##The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.##Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions." DRAMP00877 GIPCGESCVWIPCISAALGCSCKNKVCYRN 30 Circulin-A (CIRA; Plant defensin) P56871 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Alpha helix (1 helices; 4 residues) "The molecule is stabilised by three disulfide bonds, two of which form an embedded loop completed by the backbone fragments connecting the cysteine residues. A third disulfide bond threads through the centre of this loop to form a ""cystine-knot"" motif. This motif is present in a range of other biologically active proteins, including omega-contoxin GVIA and Cucurbita maxima trypsin inhibitor." 1BH4 resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Relatively ineffective against Gram-negative bacteria such as E. coli and P. aeruginosa. PTM: This is a cyclic peptide which contains three disulfide bonds 1-17; 5-19; 10-24." [Ref.10430870]Gram-positive bacterium: Staphylococcus aureus (MIC=0.19 ?M).##Gram-negative bacterium: Proteus vulgaris (MIC=54.6 ?M).##Fungi: Candida kefyr (MIC=18.6 ?M) and Candida tropicalis (MIC=19.4 ?M).##NOTE: Medium with 10 mM phosphate buffer.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM). [Ref.10430870] EC50 = 1020 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.8920961] There are three disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27" L [Ref.18008336]CEM-SS cells:IC50=500 nM. Not found 18008336##10430870##9878410##8920961 Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. ##Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##J. Mol. Biol. 1999; 285:333-345. ##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##Tam JP, Lu YA, Yang JL, Chiu KW.##Daly NL, Koltay A, Gustafson KR, Boyd MR, Casas-Finet JR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell" "Cyclotides as natural anti-HIV agents.##An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides" DRAMP00878 GVIPCGESCVFIPCISTLLGCSCKNKVCYRN 31 Circulin-B (CIRB; Plant defensin) P56879 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Beta strand (5 strands; 10 residues) Cyclotides are mini-proteins derived from plants that have the characteristic features of a head-to-tail cyclised peptide backbone and a knotted arrangement of their three disulfide bonds. 2ERI resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria. PTM: This is a cyclic peptide which contains three disulfide bonds 5-21; 9-23; 14-28." "[Ref.10430870]Gram-positive bacterium: (L-salt): Staphylococcus aureus (MIC=13.5 ?M).##Gram-negative bacteria: (L-salt, H-salt) (MIC ?M): Escherichia coli (0.41, >500), Pseudomonas aeruginosa (25.5, 48), Proteus vulgaris (6.8, >500), Klebsiella oxytoca (8.2, 15.6).##Fungi (H-salt): Candida kefyr (MIC=29 ?M).##NOTE: L-salt = Medium with 10 mM phosphate buffer; H-salt = L-salt supplemented with 100 mM NaCl.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40-260 nM)." [Ref.10430870] EC50 = 550 M against blood type A human erythrocytes. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) "[Ref.8920961] There are three disulfide bonds between Cys5 and Cys19, Cys9 and Cys21, Cys14 and Cys27." L [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 820 M.##[Ref.18008336]CEM-SS cells:IC50=500 nM. Not found 10430870##18008336##8920961 Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8918.##Biopolymers. 2008;90(1):51-60.##Biochem Biophys Res Commun. 1996 Nov 12;228(2):632-8. doi: 10.1006/bbrc.1996.1708. "Tam JP, Lu YA, Yang JL, Chiu KW.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.##R Derua 1, K R Gustafson, L K Pannell" "An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.##Cyclotides as natural anti-HIV agents.##Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides" DRAMP01517 GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC 37 "Esculentin-2P (Frogs, amphibians, animals)" P82846 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana pipiens (northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram-, Antiviral" Protein level Not found Not found None "Function: Antibacterial activity against Gram-negative bacteria. Tissue specificity: Expressed by the skin glands." [Ref.10651828]Gram-negative bacterium: Escherichia coli (MIC=10 M).##[Ref.11601906]Virus:##Frog Virus 3: 90% inhibition at 500 ?M;##Channel Catfish Virus: 90% inhibition at 50 ?M. No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys31 and Cys37. L No cytotoxicity information found in the reference(s) presented Not found 11601906##10651828 Virology. 2001 Sep 30;288(2):351-7.##Eur J Biochem. 2000 Feb;267(3):894-900. "Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.##Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.##Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP01364 GLFGVLAKVAAHVVPAIAEHF 21 "Maculatin-1.1 (Frogs, amphibians, animals)" P82066 Not found Not found Litoria genimaculata (Green-eyed tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Alpha helix Not found None "Function: Maculatin-1.1 shows significant antibacterial activity against Gram-positive bacteria, less against Gram-negative bacteria. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=25 ?g/ml), Bacillus cereus (MIC=3 ?g/ml), Listeria innocua (MIC=100 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=6 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=3 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=11.3 M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Not found 16140737##9620615##15203252 J Virol. 2005 Sep;79(18):11598-606. ##J Pept Sci. 1998 Apr;4(2):111-115.##Peptides. 2004; 25: 1035-1054. "VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. ##Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01549 GLLSVLGSVAKHVLPHVVPVIAEHL 25 "Caerin-1.1 (Frogs, amphibians, animals)" "P62568, P62569, Q800R2, P56226" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria splendida (Magnificent tree frog) (Litoria gilleni) (Litoria caerulea) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Alpha helix The peptide adopts two well-defined helices from Leu2 to Lys11 and from Val17 to His24 separated by a region of less-defined helicity and greater flexibility. None "Function: Antibacterial and antiviral peptides that adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Secreted by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility. Miscellaneous: Caerin 1.1 completely inhibits HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606). PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=1.5 ?g/ml), Listeria innocua (MIC=25 ?g/ml), Micrococcus luteus (MIC=12.5 ?g/ml), Staphylococcus aureus (MIC=3-12 ?g/ml), Staphylococcus epidermis (MIC=12.5 ?g/ml), Streptococcus uberis (MIC=12.5 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml).##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=7.8 M);inhibition of HIV transfer by dendritic cells to T cells(IC50=12.6 M)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Cell membrane 16140737##9266696##12709067##15203252 J Virol. 2005 Sep;79(18):11598-606. ##Eur J Biochem. 1997 Jul 15;247(2):545-557.##Eur J Biochem. 2003 May;270(9):2068-2081.##Peptides. 2004 Jun;25(6):1035-1054. "VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Wong H, Bowie JH, Carver JA.##Vanhoye D, Bruston F, Nicolas P, Amiche M.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.##Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01555 GLLSVLGSVVKHVIPHVVPVIAEHL 25 "Caerin-1.5 (Frogs, amphibians, animals)" P56230 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=12 ?g/ml), Staphylococcus aureus (MIC=25 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=25 ?g/ml). ##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 12.5 ?M. Not found 26026377##15203252##PubMed ID is not available Peptides. 2015 Sep;71:296-303. ##Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01560 GLFGVLGSIAKHVLPHVVPVIAEKL 25 "Caerin-1.9 (Frogs, amphibians, animals)" P81252 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria chloris (Blue-thighed frog) (frog skin active peptide family) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin dorsal glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation. Miscellaneous: Caerin 1.9 completely inhibited HIV infection of T cells within minutes of exposure to virus at concentrations that were not toxic to target cells (J Virol. 2005 Sep;79(18):11598-606)." "[Ref.15203252]Gram-positive bacteria: Bacillus cereus (MIC=100 ?g/ml), Leuconostoc lactis (MIC=12 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=50 ?g/ml), Staphylococcus aureus (MIC=100 ?g/ml), Staphylococcus epidermis (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=50 ?g/ml). ##[Ref.16140737]Virus:HIV:inhibit 50% of PBS-treated HIV infection of T cells(IC50=1.2 M);inhibition of HIV transfer by dendritic cells to T cells(IC50=1.6 M).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=4 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 20 ?M." Not found 26026377##16140737##15203252##9516047 Peptides. 2015 Sep;71:296-303. ##J Virol. 2005 Sep;79(18):11598-606. ##Peptides. 2004 Jun;25(6):1035-1054.##J Pept Res. 1998 Feb;51(2):121-126. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria." DRAMP01574 GLWQKIKSAAGDLASGIVEGIKS 23 "Caerin-4.1 (Frogs, amphibians, animals)" P56242 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Alpha helix Not found None "PTM: adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands." [Ref.15203252]Gram-positive bacterium: Micrococcus luteus (MIC=12 ?g/ml);##Gram-negative bacterium: Escherichia coli (MIC=25 ?g/ml). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.15203252]No cytotoxicity information found Not found 15203252##PubMed ID is not available Peptides. 2004 Jun;25(6):1035-1054.##J. Chem. Res. 1993; 138: 910-936. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula." DRAMP01577 GLLSVLGSVAKHVLPHVVPVIAEKL 25 "Caerin-1.10 (Frogs, amphibians, animals)" "P86502, P82104" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria rothii (Roth's tree frog); also Litoria splendida (Magnificent tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide with wide spectrum of activity. Tissue specificity: Expressed by the skin glands. PTM: C-terminal amidation." "[Ref.10601876]Gram-positive bacteria: Leuconostoc lactis (MIC=6 ?g/ml), Listeria innocua (MIC=50 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Streptococcus uberis (MIC=50 ?g/ml), Staphylococcus epidermidis (MIC=100 ?g/ml);##Gram-negative bacterium: Pasteurella multocida (MIC=100 ?g/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 22 ?M." Not found 26026377##16124032##10601876 Peptides. 2015 Sep;71:296-303. ##Rapid Commun Mass Spectrom. 2005;19(18):2716-2724.##Eur J Biochem. 2000 Jan;267(1):269-275. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Brinkworth CS, Bowie JH, Bilusich D, Tyler MJ.##Wabnitz PA, Bowie JH, Tyler MJ, Wallace JC, Smith BP." "Inhibition of HIV infection by caerin 1 antimicrobial peptides.##The rothein peptides from the skin secretion of Roth's tree frog Litoria rothii. Sequence determination using positive and negative ion electrospray mass spectrometry.##Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10." DRAMP01586 GLFKVLGSVAKHLLPHVAPIIAEKL 25 "Caerin-1.19 (Frogs, amphibians, animals)" P0C2A8 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria gracilenta (Dainty green tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral" Protein level Not found Not found None "Function: Caerin-1.19 shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms. Tissue specificity: Expressed by the skin dorsal glands. PTM: C-terminal amidation." "[Ref.16554081]Gram-positive bacteria: Bacillus cereus (MIC=50 ?g/ml), Leuconostoc lactis (MIC=3 ?g/ml), Listeria innocua (MIC=12 ?g/ml), Micrococcus luteus (MIC=25 ?g/ml), Staphylococcus aureus Strain ATCC 25923 (MIC=12 ?g/ml), Staphylococcus aureus Strain ATCC 29213 (MIC=12 ?g/ml), Staphylococcus epidermidis (MIC=12 ?g/ml), Streptococcus uberis (MIC=25 ?g/ml);##Gram-negative bacteria: Pasteurella multocida (MIC=50 ?g/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L No cytotoxicity information found in the reference(s) presented Not found 26026377##16554081 Peptides. 2015 Sep;71:296-303. ##Toxicon. 2006 May;47(6):664-675. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ." Inhibition of HIV infection by caerin 1 antimicrobial peptides.##New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. DRAMP01784 SLSRFLSFLKIVYPPAF 17 "Temporin-LTc (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Hylarana latouchii (broad-folded frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Not found Not found Not found None Comment: A mutant of the peptide is also HIV inhibitory (Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346). "Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?g/ml), Bacillus subtilis (MIC=50 ?g/ml);##Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 ?g/ml)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.19022312]No cytotoxicity information found Not found 19022312 Peptides. 2009 Feb;30(2):273-282. "Wang H, Lu Y, Zhang X, Hu Y, Yu H, Liu J, Sun J." "The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae)." DRAMP01847 GFKDLLKGAAKALVKTVLF 19 "Ascaphin-8 (Frogs, amphibians, animals)" P0CJ32 Belongs to the ascaphin family Not found Ascaphus truei (Coastal tailed frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Not found Not found None Function: Antimicrobial peptide that shows similar potency against Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity. Tissue specificity: Expressed by the skin glands. PTM: Phenylalanine amide at position 19. [Ref.15207717]Gram-negative bacterium: Escherichia coli (MIC=6 ?M);##Gram-positive bacterium: Staphylococcus aureus (MIC=6 ?M). [Ref.15207717]HC50=50 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15207717 Biochem Biophys Res Commun. 2004 Jul 16;320(1):170-175. "Conlon JM, Sonnevend A, Davidson C, Smith DD, Nielsen PF." "The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei." DRAMP02233 FISAIASMLGKFL 13 "Ranatuerin-6 (Frogs, amphibians, animals)" P82821 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Antiviral" Protein level Not found Not found None This peptide could inhibit HIV infection <10% at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). Gram-positive bacterium: Staphylococcus aureus (MIC=100 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP02236 FLFPLITSFLSKVL 14 "Ranatuerin-9 (Frogs, amphibians, animals)" P82824 Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) "Antimicrobial, Antibacterial, Anti-Gram+, Antiviral" Protein level Not found Not found None "This peptide was found to be HIV active, EC50= 16.7 uM (Wang, G et al., 2010 Antimicrob Agents Chemother 54: 1343)." Gram-positive bacterium: Staphylococcus aureus (MIC=130 ?M). No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9784389 Biochem Biophys Res Commun. 1998 Sep 29;250(3):589-592. "Goraya J, Knoop FC, Conlon JM." "Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana." DRAMP01107 GIGTKILGGVKTALKGALKELASTYAN 27 "Maximin-1 (Toads, amphibians, animals)" "P83080, Q58T87" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity. Toxic dose: LD50 is 8.2 mg/kg by intraperitoneal injection into mice. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=19.5 ?g/ml), Klebsiella pneumoniae (MIC=9 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=19.5 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=19.5 ?g/ml), Bacillus megatherium (MIC=19.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=3 ?g/ml);##Virus: HIV-1 (IC50=15.5 ?g/ml, EC50=21.4 ?g/ml);##Cancer cell lines: C8166 (IC50=15.3 ?g/ml), Molt-4 (IC50=24.3 ?g/ml), BIU-87 (IC50=20.5 ?g/ml), T24 (IC50=35.4 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP03113 SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK 84 "SK84 (Gly-rich; Insects, animals)" No entry found Not found Not found Drosophila virilis (Fruit fly) "Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiviral" Not found Not found Not found None "Function: SK84 displays antibacterial activity against the tested Gram-positive bacteria (B. subtilis, Bacillus thuringiensis and Staphylococcus aureus), but had no effect on Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and fungi (Saccharomyces cerevisiae, Candida albicans). Has weak hemolytic activity." "[Ref.19799950]Gram-positive bacteria: Bacillus thuringiensis ATCC 1041 (MIC=4 ?M), B. subtilis ATCC 9372 (MIC=8 ?M), Staphylococcus aureus ATCC 6538 (MIC=8 ?M)." [Ref.19799950]0.01% hemolytic activity at 100 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19799950 Peptides. 2010 Jan;31(1):44-50. "Lu J, Chen ZW." "Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis." DRAMP03280 ATYDGKCYKKDNICKYKAQSGKTAICKCYVKVCPRDGAKCEFDSYKGKCYC 51 AcAMP (A. clavatus antimicrobial peptide) No entry found Not found Not found Aspergillus clavatus ES1 "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Not found Not found Not found None "This basic, Cys-rich antifungal peptide is also active against bacteria. AcAMP was sensitive to proteolytic enzymes, stable between pH 5.0 and 10.0, and heat resistant (15 min at 100 degrees C). " "Gram-positive bacteria: Staphylococcus aureus (MIC=20 ?g/ml), Bacillus cereus (MIC=10 ?g/ml), Micrococcus luteus (MIC=10 ?g/ml), Enterococcus faecalis (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli (MIC=30 ?g/ml), Pseudomonas aeruginosa (MIC=50 ?g/ml).##Fungi: Aspergillus niger, Fusarium solani, Fusarium oxysporum." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20440534 J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-813. "Hajji M, Jellouli K, Hmidet N, Balti R, Sellami-Kamoun A, Nasri M." A highly thermostable antimicrobial peptide from Aspergillus clavatus ES1: biochemical and molecular characterization. DRAMP03422 ACYCRIGACVSGERLTGACGLNGRIYRLCCR 31 "Neutrophil antibiotic peptide NP-4 (RatNP-4; Rodents, mammals, animals)" Q62714 Belongs to the alpha-defensin family Np4 Rattus norvegicus (Rat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Bridge Not found None "Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus." "Gram-positive bacterium: Staphylococcus aureus 502A (MIC=50 ?g/ml);##Gram-negative bacteria: Escherichia coli ML-35, Acinetobacter calcoaceticus (MIC=50 ?g/ml).Fungi: Cryptococcus neoformans (MIC=10 ?g/ml), Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29." L No cytotoxicity information found Not found 2543629##7594610 Infect. Immun. 1989;57:2021-2027.##J. Immunol. 1995;155:4476-4484. "Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Selsted M.E, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E." Purification and antimicrobial properties of three defensins from rat neutrophils.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. DRAMP03465 NEYHGFVDKANNENKRKKQQGRDDFVVKPNNFANRRRKDDYNENYYDDVDAADVV 55 "Cicadin (Insects, animals)" P83282 Not found Not found Cicada flammata "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None "Function: Possesses antifungal activity against B.cinerea, M.arachidicola, F.oxysporum, R.solani and C.comatus. Suppresses the activity of HIV-1 reverse transcriptase and stimulates the proliferation of murine splenocytes." "Fungi: Botrytis cinerea (MIC=100 nM), Mycosphaerella arachidicola (MIC=70 nM), Fusarium oxysporum (MIC=180 nM), Physalospora piricola (MIC=60 nM), Rhizoctonia solani, Coprinus comatus, HIV-1 reverse transcriptase." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11814612 Peptides. 2002;23:7-11. "Wang H, Ng TB." "Isolation of cicadin, a novel and potent antifungal peptide from dried juvenile cicadas." DRAMP03598 GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP 41 "Human beta-defensin 2 (hBD-2; Defensin, beta 2; Beta-defensin 4A; Human, mammals, animals)" "O15263, Q52LC0" Belongs to the beta-defensin family DEFB4A AND DEFB4B Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Combine helix and strand structure The structure (one N-terminal helix and 3 beta strands) was found to be monomer in solution (PDB ID: 1E4Q) but a dimer in the crystal (PDB ID: 1FD3). "1FD4, 1FD3 resolved by X-ray.##1FQQ resolved by NMR." "Function: Has anti-HIV and antibacterial activity. Tissue specificity: Expressed in the skin and respiratory tract. Induction: By inflammation. PTM: Contains three disulfide bonds 8-37, 15-30, 20-38. Transgenic plants: expression of this peptide in Arabidopsis thaliana reduced fungal infection." "Gram-negative bacteria: Escherichia coli D31(MIC=62 ?g/ml), Escherichia coli ATCC (MIC=62 ?g/ml), Pseudomonas aeruginosa ATCC (MIC=62 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC (MIC=62 ?g/ml), Enterococcus faecalis ATCC (MIC=15 ?g/ml)." [Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 g/ml. Cyclic Free Free "Disulfide bonds between Cys8 and Cys37,Cys15 and Cys30,Cys20 and Cys38." L No cytotoxicity information found Not found 9202117##10906336##17340092 Nature. 1997 Jun 26;387(6636):861.##J Biol Chem. 2000 Oct 20;275(42):32911-32918.##Plant Cell Rep. 2007 Aug;26(8):1391-1398. "Harder J, Bartels J, Christophers E, Schr?der JM.##Hoover DM, Rajashankar KR, Blumenthal R, Puri A, Oppenheim JJ, Chertov O, Lubkowski J.##Aerts AM, Thevissen K, Bresseleers SM, Sels J, Wouters P, Cammue BP, Fran?ois IE." A peptide antibiotic from human skin.##The structure of human beta-defensin-2 shows evidence of higher order oligomerization.##Arabidopsis thaliana plants expressing human beta-defensin-2 are more resistant to fungal attack: functional homology between plant and human defensins. DRAMP02926 KWCFRVCYRGICYRRCR 17 "Tachyplesin I (Tac; TP1; Horseshoe Crab, arachnids, Chelicerata, arthropods, invertebrates, animals)" P14213 Belongs to the tachyplesin/polyphemusin family. Not found Tachypleus tridentatus (Japanese horseshoe crab) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Anti-HIV, Anti-cancer" Protein level Beta strand This stability is due to the rigid structure imposed by the two disulfide linkages. Its amphipathic nature is closely associated with biological activity. A "1MA2, 1MA5, 6PIN, 1WO0, 1WO1, 2MDB, 2RTV resolved by NMR." "Function: Significantly inhibits the growth of Gram-negative and Gram-positive bacteria, also anti-HIV activity may be due to the inhibition of virual adsorption to cells. PTM: Contains two disulfide bonds 3-16; 7-12 and Arginine amide at R17." No MICs found in DRAMP database [Ref.29870123] 9.6% hemolytic activity at 8 g/mL and 72.8% hemolytic activity at 512 g/mL against human red blood cells. Cyclic Free Amidation (Arg17) "Disulfide bond between Cys3 and Cys16,Cys7 and Cys12." L "[Ref.28429216]It possessed a cytotoxic effect on HL-60 cells (acutehuman promyelocytic leukemia cells) , K562 cells(myelogenous leukemia cells) , TSU cells (prostatecancer cells) ." Cell membrane 12369825##2229025 Biochemistry 2002; 41: 12359.##J Biochem. 1990 Aug;108(2):261-266. "Laederach A, Andreotti AH, Fulton, DB.##Muta T, Fujimoto T, Nakajima H, Iwanaga S." "Solution and Micelle-Bound Structures of Tachyplesin I and its Active Aromatic Linear Derivatives.##Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor." DRAMP04528 TCRYWCKTPENQTYCCEDEREIPSKVGLKPGKCPPVRPVCPPTRGFFEPPKTCSNDGSCYGADKCCFDRCLGEHVCKPIQTRG 83 CrusEs (cDNA encoding crustin-like peptide) No entry found Not found Not found "Chinese mitten crab, Eriocheir sinensis" "Antibacterial, Antifungal, Antiviral, In, Anti-Gram+, Antimicrobial" Not found Not found Not found None Function: CrusEs is a potent antibacterial protein against Gram-positive bacteria infection. "Gram-positive bacteria: M. luteus (MIC=0.23 ?M), B. subtilis (MIC=0.11 ?M), B. thuringiensis (MIC=0.11 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20144896 Dev Comp Immunol. 2010 Jul;34(7):734-740. "Mu C, Zheng P, Zhao J, Wang L, Zhang H, Qiu L, Gai Y, Song L." "Molecular characterization and expression of a crustin-like gene from Chinese mitten crab, Eriocheir sinensis." DRAMP18350 CLGIGSCNDFAGCGYAIVCFW 21 Siamycin II(Bacteriocin) No entry found Belongs to the class I bacteriocin Not found Streptomyces strains AA3891 "Antiviral, Anti-HIV, Antimicrobial" Beta strand "It differs from Siamycin I only by one amino acid. Siamycin I has a valine residue at position 4. In both peptides, disulfide bonds link Cys1 with Cys13 and Cys7 with Cys19, and the side chain of Asp9 forms an amide bond with the N-terminus (XXJ). The original has been replaced since antimicrobial assays revealed no activity." None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7787424 J Biomol NMR. 1995 Apr;5(3):271-86. "Constantine KL, Friedrichs MS, Detlefsen D, Nishio M, Tsunakawa M, Furumai T, Ohkuma H, Oki T, Hill S, Bruccoleri RE, et al." High-resolution solution structure of siamycin II: novel amphipathic character of a 21-residue peptide that inhibits HIV fusion. DRAMP18349 CLGVGSCNDFAGCGYAVVCFW 21 Siamycin I (Bacteriocin) No entry found Belongs to the class I bacteriocin Not found Streptomyces strain AA6532 "Antiviral, Anti-HIV, Antimicrobial" Beta strand "It differs from Siamycin I only by one amino acid. Siamycin I has a valine residue at position 4. In both peptides, disulfide bonds link Cys1 with Cys13 and Cys7 with Cys19, and the side chain of Asp9 forms an amide bond with the N-terminus (XXJ). The original has been replaced since antimicrobial assays revealed no activity." None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8557614 J Antibiot (Tokyo). 1995 Dec;48(12):1515-7. "Detlefsen DJ, Hill SE, Volk KJ, Klohr SE, Tsunakawa M, Furumai T, Lin PF, Nishio M, Kawano K, Oki T, et al." "Siamycins I and II, new anti-HIV-1 peptides: II. Sequence analysis and structure determination of siamycin I." DRAMP18347 CLGVGSCNDFAGCGYAIVCFW 21 Siamycin(Bacteriocin) No entry found Belongs to the class I bacteriocin Not found Streptomyces sp. No. 73264 "Antiviral, Anti-HIV, Antimicrobial" Not found It differs from siamycin I only at position 17 (V to I). None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8619594 Antimicrob Agents Chemother. 1995 Oct;39(10):2345-7. "Chokekijchai S, Kojima E, Anderson S, Nomizu M, Tanaka M, Machida M, Date T, Toyota K, Ishida S, Watanabe K, et al." NP-06: a novel anti-human immunodeficiency virus polypeptide produced by a Streptomyces species. DRAMP18345 CLGIGSCNNFAGCGYAVVCFW 21 Tricyclic peptide RP 71955 (Bacteriocin) P37046 Not found Not found Streptomyces sp. (strain SP9440) "Antiviral, Anti-HIV, Antimicrobial" Beta strand "An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19." "1RPB, 1RPC resolved by NMR" "Caution:The isopeptide linked residue 9 is shown as Asn rather than Asp as mentioned in PubMed:8286361, because it is not known whether Asp or Asn is encoded and the isopeptide bonds are almost always formed between the amides Asn or Gln and N6-lysine or alpha amino groups, with the liberation of an ammonia that makes the reaction essentially irreversible.(From Swiss-prot)" No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8270499 J Antibiot (Tokyo). 1993 Nov;46(11):1756-7. "Helynck G, Dubertret C, Mayaux JF, Leboul J." "Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite." DRAMP00060 CRQSCSFGPFTFVCDGNTK 19 Bacteriocin cinnamycin (Lanthiopeptin Ro 09-0198) P29827 Belongs to the type B lantibiotic family (Class I bacteriocin) cinA Streptomyces cinnamoneus cinnamoneus DSM 40005 (Gram-positive bacteria) "Antimicrobial, Antbacterial, Antiviral" Protein level Beta strand (2 strands; 2 residues) The peptide has a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. 2DDE resolved by NMR. "Function: Can act as inhibitor of the enzyme phospholipase A2, and of the angiotensin-converting enzyme. Shows inhibitory activities against herpes simplex virus and immunopotentiating activities. Its antimicrobial activities are not very pronounced. PTM: Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor." "Bacillus, herpes simplex virus." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet phosphatidylethanolamine 2125590##2544544##8882709 J Antibiot (Tokyo). 1990 Nov;43(11):1403-1412.##J Antibiot (Tokyo). 1989 Jun;42(6):837-845.##J Biochem. 1996 Feb;119(2):226-230. "Fredenhagen A, Fendrich G, M?rki F, M?rki W, Gruner J, Raschdorf F, Peter HH.##Naruse N, Tenmyo O, Tomita K, Konishi M, Miyaki T, Kawaguchi H, Fukase K, Wakamiya T, Shiba T.##Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K." "Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.##Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.##Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1." DRAMP18344 CLGIGSCNNFAGCGYAVVCFW 21 Tricyclic peptide RP 71955 (Bacteriocin) P37046 Belongs to the class I bacteriocin Not found Streptomyces sp. (strain SP9440) "Antiviral, Anti-HIV, Antimicrobial" Beta strand "An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19. In contrast. Class 2 lassos do not have disulfide bonds." "1RPB, 1RPC resolved by NMR" "Caution:The isopeptide linked residue 9 is shown as Asn rather than Asp as mentioned in PubMed:8286361, because it is not known whether Asp or Asn is encoded and the isopeptide bonds are almost always formed between the amides Asn or Gln and N6-lysine or alpha amino groups, with the liberation of an ammonia that makes the reaction essentially irreversible.(From Swiss-prot)" No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8270499 J Antibiot (Tokyo). 1993 Nov;46(11):1756-7. "Helynck G, Dubertret C, Mayaux JF, Leboul J." "Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite." DRAMP00205 CLGIGSCNDFAGCGYAVVCFW 21 Tricyclic peptide RP 71955 (Bacteriocin) "P37046, Q7M104" Belongs to the class 1 lasso peptide Not found Streptomyces sp. (strain SP9440) (Gram-positive bacteria) "Antimicrobial, Antiviral" Protein level Beta strand Not found "1RPB, 1RPC resolved by NMR." Function: Active against HIV-1 virus in vitro. Virus: HIV-1 No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization of a N-terminal between Cys1 and Asp9 Free "Disulfide bonds between Cys1 and Cys 13,Cys 7 and Cys19." L No cytotoxicity information found Not found 8270499##8286361 J Antibiot (Tokyo). 1993 Nov;46(11):1756-1757.##Biochemistry. 1994 Jan 11;33(1):42-50. "Helynck G, Dubertret C, Mayaux JF, Leboul J.##Frchet D, Guitton JD, Herman F, Faucher D, Helynck G, Monegier du Sorbier B, Ridoux JP, James-Surcouf E, Vuilhorgne M." "Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.##Solution structure of RP 71955, a new 21 amino acid tricyclic peptide active against HIV-1 virus." DRAMP00245 VGALAVVVWLWLWLW 15 Gramicidin A (GA; Nonribosomally synthesized bacteriocin) No entry found Not found Not found Bacillus brevis (soil bacterium) (Gram-positive bacteria) "Antimicrobial, Antbacterial, Antiviral" Not found Beta strand (1 strands; 13 residues) "Amino acids 4, 6, 8, 10, and 12 are D-amino acids, allowing the formation of a special helical structure that head-to-head dimerizes into a cation channel in lipid bilayer with the C-terminus exposed. Structures solved in organic solvents by x-ray diffraction are believed to be non-channel forms. " 1MAG resolved by NMR. Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19870884##8810522 J Exp Med. 1939 Jun 30;70(1):1-10.##J Biomol NMR. 1996 Jul;8(1):1-14. "Dubos RJ.##Ketchem RR, Lee KC, Huo S, Cross TA." STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : I. PREPARATION OF THE AGENT. ITS ACTIVITY IN VIT.##Macromolecular structural elucidation with solid-state NMR-derived orientational constraints. DRAMP00246 VGALAVVVWLFLWLW 15 Gramicidin B (GB; Bacteriocin) No entry found Not found Not found Bacillus brevis (soil bacterium) (Gram-positive bacteria) "Antimicrobial, Antbacterial, Antiviral" Not found Beta strand (1 strands; 13 residues) Not found 1JO3 resolved by NMR. Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11570868 Biochemistry 2001; 40: 11676-11686. "Townsley, L.E, Tucker, W.A, Sham, S, Hinton, J.F." "Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles." DRAMP00247 VGALAVVVWLYLWLW 15 Gramicidin C (GC; Bacteriocin) No entry found Not found Not found Bacillus brevis (soil bacterium) (Gram-positive bacteria) "Antimicrobial, Antbacterial, Antiviral" Not found Beta strand (1 strands; 13 residues) Not found 1JO4 resolved by NMR. Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11570868 Biochemistry 2001; 40: 11676-11686. "Townsley, L.E, Tucker, W.A, Sham, S, Hinton, J.F." "Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles." DRAMP00261 GSGPTYCWNEANNPGGPNRCSNNKQCDGARTCSSSGFCQGTSRKPDPGPKGPTYCWDEAKNPGGPNRCSNSKQCDGARTCSSSGFCQGTAGHAAA 95 Antiviral lectin scytovirin (SVN) P86041 Not found Not found Scytonema varium (cyanobacterium) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure Not found 2QT4 resolved by X-ray. "Function: Has strong anti-HIV activity against T-tropic strains of HIV-1 and weaker activity against M-tropic strains of HIV-1. Inhibits HIV-1 fusion and infection of CD4 LTR beta-gal cells in vitro. Inhibits fusion of HIV infected CEM-SS cells with uninfected CEM-SS cells, and fusion of HIV-1 Env expressing HL2/3 cells with CD4 LTR beta-gal cells. Binds to HIV gp120, HIV gp160 and to a lesser extent HIV gp41. Binding to HIV gp120 is glycosylation dependent. Binds with high specificity to the tetrasaccharide Man-alpha-1,2-Man-alpha-1,6-Man-alpha-1,6-Man and also binds the higher-order oligosaccharides oligomannose 8 and oligomannose 9. Does not bind to monosaccharides, complex or hybrid N-linked oligosaccharides or chitin. PTM: Contains five disulfide bonds." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12614152##16647158##17965185 Biochemistry. 2003 Mar 11;42(9):2578-2584.##Peptides. 2006 Jul;27(7):1668-1675.##Protein Sci. 2007 Dec;16(12):2756-2760. "Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC 2nd, Turpin J, Watson K, Buckheit RW Jr, Boyd MR.##Xiong C, O'Keefe BR, Byrd RA, McMahon JB.##Moulaei T, Botos I, Zi?kowska NE, Bokesch HR, Krumpe LR, McKee TC, O'Keefe BR, Dauter Z, Wlodawer A." A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium.##Potent anti-HIV activity of scytovirin domain 1 peptide.##Atomic-resolution crystal structure of the antiviral lectin scytovirin. DRAMP00262 LGKFSQTCYNSAIQGSVLTSTCERTNGGYNTSSIDLNSVIENVDGSLKWQPSNFIETCRNTQLAGSSELAAECKTRAQQFVSTKINLDDHIANIDGTLKYE 101 Cyanovirin-N (CV-N) P81180 Belongs to the cyanovirin-N family Not found Nostoc ellipsosporum (cyanobacterium) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure Not found 2EZM resolved by NMR. "Function: Mannose-binding lectin. Biotechnological use: Overexpression of this protein to provide quantities adequate for medical use as a topical microbiocide has been attempted in a number of systems including E.coli, Lactobacillus jensenii, the yeast Pichia pastoris and Nicotiana tabacum. One fusion construct for overexpression of this protein can be found in entry AC D1WFZ2. Miscellaneous: Its activity in situ is Not found, however it acts as a viral entry inhibitor, inhibiting HIV-1, HIV-2 and simian immunodeficiency virus (and some other viruses such as feline immunodeficiency virus, measles virus and human herpesvirus) infection and replication. It prevents essential interactions between the envelope glycoprotein and target cell receptors by binding to carbohydrates on viral protein gp120 and possibly by other mechanisms as well. Addition to cells must occur before or shortly after virus addition. It also inhibits cell-to-cell fusion, and virus-to-cell and cell-to-cell transmission of a viral infection. Is remarkably stabile; the protein can withstand multiple freeze-thaw cycles, dissolution in organic solvents, treatment with salt, detergent, H2O2 and boiling without significant loss of anti-HIV activity." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9210678##9665171 Antimicrob Agents Chemother. 1997 Jul;41(7):1521-1530.##Nat Struct Biol. 1998 Jul;5(7):571-578. "Boyd MR, Gustafson KR, McMahon JB, Shoemaker RH, O'Keefe BR, Mori T, Gulakowski RJ, Wu L, Rivera MI, Laurencot CM, Currens MJ, Cardellina JH 2nd, Buckheit RW Jr, Nara PL, Pannell LK, Sowder RC 2nd, Henderson LE.##Bewley CA, Gustafson KR, Boyd MR, Covell DG, Bax A, Clore GM, Gronenborn AM." "Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.##Solution structure of cyanovirin-N, a potent HIV-inactivating protein." DRAMP00264 EQCREEEDDR 10 Coconut antifungal peptide (Plants) No entry found Not found Not found Cocos nucifera "Antimicrobial, Antifungal, Antiviral" Not found Not found Not found None Function: Also has HIV-1 reverse transcriptase activity (IC50=52.5 ?M) "Fungi: Fusarium oxysporum, Mycosphaerella arachidicola (IC50=1.2 ?M), Physalospora piricola." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16308082 Peptides. 2005 Dec;26(12):2392-2396. "Wang HX, Ng TB." An antifungal peptide from the coconut. DRAMP00272 AKITFTNNHPRTIWP 15 Thaumatin-like protein (Plants) P83957 Belongs to the thaumatin family Not found Castanopsis chinensis (Chinese chinquapin) (Kweilin chestnut) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Comment: No comments found on DRAMP database "Fungi: Botrytis cinerea, Fusarium oxysporum (IC50=0.5 ?M), Mycosphaerella arachidicola, Psylla piricola.##HIV-1 reverse transcriptase (IC50=1.6 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12565869 Biochem Biophys Res Commun. 2003 Feb 7;301(2):364-370. "Chu KT, Ng TB." Isolation of a large thaumatin-like antifungal protein from seeds of the Kweilin chestnut Castanopsis chinensis. DRAMP00279 AQIVKLGGDDGSLAFVPSKISVAAGEAIEFVNNAGFPHNIVFDEDAVPAGVDADAISYDDYLNSKGETVVRKLSTPGVYGVYCEPHAGAGMKMTITVQ 98 Plastocyanin (Plants) P56274 Not found PETE Ulva pertusa (Sea lettuce) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure Not found 1IUZ resolved by X-ray. "Function: Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I. Has antiviral activity against Potato virus Y (strain N). Domain: Contains 1 plastocyanin-like domain." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9933621##PubMed ID is not availbale J Biol Chem. 1999 Feb 12;274(7):4225-4230.##Submitted (JUN-2003) to UniProtKB. "Shibata N, Inoue T, Nagano C, Nishio N, Kohzuma T, Onodera K, Yoshizaki F, Sugimura Y, Kai Y.##" Novel insight into the copper-ligand geometry in the crystal structure of Ulva pertusa plastocyanin at 1.6-A resolution. Structural basis for regulation of the copper site by residue 88.## DRAMP00299 DADIAVWAPPVNAQN 15 Ribonuclease (Plants) P84784 Not found Not found Thelephora ganbajun (Mushroom) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: Inhibits HIV-1 reverse transcriptase. Miscellaneous: Inhibits HIV-1 reverse transcriptase with an IC50 of 300 nM. Biophysicochemical properties: pH dependence (Optimum pH is 6-7); Temperature dependence (Optimum temperature is 45 degrees Celsius. Activity decreases sharply above 50 degrees Celsius and below 40 degrees Celsius)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15474506 Biochem Biophys Res Commun. 2004 Nov 12;324(2):855-859. "Wang HX, Ng TB." Purification of a novel ribonuclease from dried fruiting bodies of the edible wild mushroom Thelephora ganbajun. DRAMP00333 AVKTITLNLVSPSANRYATFLTEIRDNVRXRSLDYSHSGIDVIGAPSSRDSXLNINFQSP 60 Antiviral protein DAP-32 (Ribosome-inactivating protein; Plant defensin) P24477 Belongs to the ribosome-inactivating protein family (Type 1 RIP subfamily) Not found Dianthus caryophyllus (Carnation) (Clove pink) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: Single-chain ribosome-inactivating protein, possessing high antiviral potency and low toxicity to normal cells in culture and to intact animals. Capable of inhibiting HIV-1 infection and replication. Catalytic activity: Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA." "Syncytkia (IC50=0.76 nM), viral coreprotein P24 (IC50=0.71 nM), HIV-RT (IC50=0.76 nM)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1936243 FEBS Lett. 1991 Oct 7;291(1):139-144. "Lee-Huang S, Kung HF, Huang PL, Huang PL, Li BQ, Huang P, Huang HI, Chen HC." "A new class of anti-HIV agents: GAP31, DAPs 30 and 32." DRAMP00334 GLDTVSFSTKGATYITYVNFLNELRVKTKPEGNSHGIPSLRKSSDDPGSSFVVAG 55 Antiviral protein GAP-31 (Ribosome-inactivating protein; Plant defensin) P24475 Belongs to the ribosome-inactivating protein family (Type 1 RIP subfamily) Not found Suregada multiflora (False lime) (Gelonium multiflorum) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: Single-chain ribosome-inactivating protein, possessing high antiviral potency and low toxicity to normal cells in culture and to intact animals. Capable of inhibiting HIV-1 infection and replication. Catalytic activity: Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1936243 FEBS Lett. 1991 Oct 7;291(1):139-144. "Lee-Huang S, Kung HF, Huang PL, Huang PL, Li BQ, Huang P, Huang HI, Chen HC." "A new class of anti-HIV agents: GAP31, DAPs 30 and 32." DRAMP00339 GADFQECMKEHSQKQHQHQG 20 Alpha-basrubrin (Fragment; Plants) P83186 Not found Not found Basella alba (Malabar spinach) (Basella rubra) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Function: Inhibits HIV-1 reverse transcriptase and cell-free translation. "Fungi: Botrytis cinerea, Mycosphaerella arachidicola, Fusarium oxysporum." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11688973 Biochem Biophys Res Commun. 2001 Nov 9;288(4):765-770. "Wang H, Ng T.B." Novel antifungal peptides from ceylon spinach seeds. DRAMP00340 KIMAKPSKFYEQLRGR 16 Beta-basrubin (Plants) P83187 Not found Not found Basella alba (Malabar spinach) (Basella rubra) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Function: Possesses antifungal activity. Inhibits HIV-1 reverse transcriptase and cell-free translation. "Fungi: Botrytis cinerea, Mycosphaerella arachidicola, Fusarium oxysporum." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11688973 Biochem Biophys Res Commun. 2001 Nov 9;288(4):765-770. "Wang H, Ng T.B." Novel antifungal peptides from ceylon spinach seeds. DRAMP00341 ANTAFVSSAHNTQKIPAGAPFNRNLRAMLADLRQNAAFAG 40 "Antifungal protein ginkbilobin-1 (Ginkbilobin, GNL; Plants)" P83171 Not found GNK1 Ginkgo biloba (Ginkgo) (Maidenhair tree) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Not found Not found None Function: Also inhibits HIV-1 reverse transcriptase and proliferation of murine splenocytes. "Gram-positive bacterium: Staphylococcus aureus;##Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli.##Fuungi: Botrytis cinerea, Mycosphaerella arachidicola, Fusarium oxysporum, Rhizoctonia solani, Coprinus comatus," No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11118300 Biochem Biophys Res Commun. 2000 Dec 20;279(2):407-411. "Wang H, Ng T.B." "Ginkbilobin, a novel antifungal protein from Ginkgo biloba seeds with sequence similarity to embryo-abundant protein." DRAMP00361 ITCPQVTQSLAPCVPYLISG 20 Non-specific lipid-transfer protein (LTP; Harmalin; Plants) B3EWH4 Belongs to the plant LTP family Not found Peganum harmala (Syrian rue) (Harmal peganum) "Antimicrobial, Antifungal, Antiviral, Anti-cancer" Protein level Not found Not found None "Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. Inhibits cell proliferation of cervical carcinoma cell line HeLa (IC50=2.74 ?M), gastric carcinoma cell line MGC-7 (IC50=3.13 ?M), esophageal carcinoma cell line Eca-109 (IC50=0.7 ?M) and melanoma B16 cells (IC50=1.47 ?M). Has antifungal activity. Induces caspase-dependent apoptosis in cell line Eca-109. Demonstrates inhibitory effect on HIV-1 reverse transcriptase (IC50=1.26 ?M). Biophysicochemical properties: pH dependence (Stable between pH 4 and 10); Temperature dependence (Thermostable. Retains antifungal activity between 4 degrees Celsius and 60 degrees Celsius. Activity reduced after 30 min at 80 degrees Celsius)." "Fungi: Penicillium digitatum (IC50=37.5 ?M), Alternaria alternata (IC50=1.5 ?M), Rhizopus stolonifer (IC50=8.44 ?M) and Magnaporthe grisea (IC50=12.19 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Lipid-binding PubMed ID is not available Submitted (MAR-2012) to UniProtKB "Ma XJ, Liu DL, Tang HS, Wang Y, Sun SR." "Purification and characterization of a novel protein from Peganum harmala seeds with antifungal, antiproliferation and anti-HIV-1 reverse transcriptase activities." DRAMP00409 KTCENLADTY 10 Defensin-like protein (Sesquin; Plant defensin) P84868 Belongs to the DEFL family Not found Vigna unguiculata subsp. sesquipedalis (Yard-Long bean) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Protein level Not found Not found None Function: Has antifungal and antibacterial activity. Has mitogenic activity towards murine splenocytes. Inhibits the proliferation of M1 leukemia and MCF-7 breast cancer cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase. "Fungi: Botrytis cinerea (IC50=2.50.01 ?M), Fusarium oxysporum (IC50=1.40.02 ?M), Mycosphaerella arachidicola (IC50=0.150.002 ?M).##Gram-positive bacteria: Bacillus megaterium, Mycobacterium phlei;##Gram-negative bacteria: Escherichia coli, Proteus vulgaris." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15949629 Peptides. 2005 Jul;26(7):1120-1126. "Wong JH, Ng TB" "Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase." DRAMP00427 AICKKPSKFFKGACGRDADCEKACDQENWPGGVCVPFLRCECQRSC 46 Defensin-like protein AX1 (Antifungal protein AX1; Plant defensin) P81493 Belongs to the DEFL family Not found Beta vulgaris (Sugar beet) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Not found Not found None "Function: Strong inhibiting activity against C. beticola and other filamentous fungi. Little or no effect against bacteria. Tissue specificity: Leaves and flowers. PTM: Contains four disulfide bonds 3-46; 14-34; 20-40; 24-42 (By similarity)." "Fungi: Cercospora beticola, Botrytis cinerea, Fusarium graminearum, Bipolaris maydis." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7655063 Mol Plant Microbe Interact. 1995 May-Jun;8(3):424-434. "Kragh KM, Nielsen JE, Nielsen KK, Dreboldt S, Mikkelsen JD." Characterization and localization of new antifungal cysteine-rich proteins from Beta vulgaris. DRAMP00428 ATCRKPSMYFSGACFSDTNCQKACNREDWPNGKCLVGFKCECQRPC 46 Defensin-like protein AX2 (Antifungal protein AX2; Cys-rich; Plant defensin) "P82010, P81510" Belongs to the DEFL family Not found Beta vulgaris (Sugar beet) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Not found Not found None "Function: Strong inhibiting activity against C. beticola and other filamentous fungi. Little or no effect against bacteria. Tissue specificity: Leaves and flowers. PTM: Contains four disulfide bonds 3-46; 14-34; 20-40; 24-42 (By similarity)." "Fungi: Cercospora beticola, Botrytis cinerea, Fusarium graminearum, Bipolaris maydis." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 7655063 Mol Plant Microbe Interact. 1995 May-Jun;8(3):424-434. "Kragh KM, Nielsen JE, Nielsen KK, Dreboldt S, Mikkelsen JD." Characterization and localization of new antifungal cysteine-rich proteins from Beta vulgaris. DRAMP00762 GLPVCGETCFGGTCNTPGCTCDPWPVCTRN 30 Vaby D (Plant defensin) No entry found Not found Not found Viola abyssinica (Ethiopian highlands) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Bridge Not found None PTM: Contains three disulfide bonds No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21434649 J Nat Prod. 2011 Apr 25;74(4):727-731. "Yeshak MY, Burman R, Asres K, G?ransson U." Cyclotides from an extreme habitat: characterization of cyclic peptides from Viola abyssinica of the Ethiopian highlands. DRAMP00763 GLPVCGETCAGGTCNTPGCSCSWPICTRN 29 Vaby A (Plant defensin) No entry found Not found Not found Viola abyssinica (Ethiopian highlands) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Bridge Not found None PTM: Contains three disulfide bonds No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 21434649 J Nat Prod. 2011 Apr 25;74(4):727-731. "Yeshak MY, Burman R, Asres K, G?ransson U." Cyclotides from an extreme habitat: characterization of cyclic peptides from Viola abyssinica of the Ethiopian highlands. DRAMP00788 GLPICGETCVGGTCNTPGCSCSWPVCTRN 29 Varv peptide E (Varv E; Plant defensin) P83835 Belongs to the cyclotide family Not found Viola arvensis (European field pansy) (Field violet) "Anti-cancer, Antiviral" Protein level Not found Not found None "Function: Probably participates in a plant defense mechanism. Has cytotoxic activity against human lymphoma U-937 GTB and human myeloma RPMI-8226/s cell lines. PTM: Contains three disulfide bonds 5-19; 9-21; 14-26." "[Ref.14987049]Human cancer cell lines: U-937 GTB (lymphoma) (IC50=4 ?M), RPMI-8226/s (myeloma) (IC50=4 ?M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=350 nM)." [Ref.20580652] HD50=6.96?M against human type O red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys26. L "[Ref.20580652] Cytotoxicity: U251(IC50=38.84g/mL), MDA-MB-231(IC50>10g/mL), A549(IC50>10g/mL), DU145(IC50>10g/mL), BEL-7402(IC50>10g/mL).##[Ref.14987049] Cytotoxicity: U-937 GTB (lymphoma)(IC50 = 4 ?M) and RPMI-8226/s (myeloma)(IC50 = 4 ?M).##[Ref.18008336]CEM-SS cells:IC50=3980 nM." Not found 18008336##10075760##14987049##20580652 Biopolymers. 2008;90(1):51-60.##J Nat Prod. 1999 Feb;62(2):283-286.##J Nat Prod. 2004 Feb;67(2):144-147.##Peptides. 2010 Aug;31(8):1434-40. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##G?ransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P.Svang.##Svang?rd E, G?ransson U, Hocaoglu Z, Gullbo J, Larsson R, Claeson P, Bohlin L.##Tang J, Wang CK, Pan X, Yan H, Zeng G, Xu W, He W, Daly NL, Craik DJ, Tan N." Cyclotides as natural anti-HIV agents.##Seven novel macrocyclic polypeptides from Viola arvensis.##Cytotoxic cyclotides from Viola tricolor.##Isolation and characterization of cytotoxic cyclotides from Viola tricolor. DRAMP00799 GVIPCGESCVFIPCISAAIGCSCKNKVCYRN 31 Cycloviolin-A (Plant defensin) P84637 Belongs to the cyclotide family Not found Leonia cymosa (Sacha uba) "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has anti-HIV activity. PTM: This is a cyclic peptide which may contain three disulfide bonds 5-21;9-23;14-28." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=130 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys5 and Cys21, Cys9 and Cys23,Cys14 and Cys28." L [Ref.18008336]CEM-SS cells:IC50=560 nM. Not found 10813905##18008336 J Org Chem. 2000 Jan 14;65(1):124-128.##Biopolymers. 2008;90(1):51-60. "Hallock YF, Sowder RC 2nd, Pannell LK, Hughes CB, Johnson DG, Gulakowski R, Cardellina JH 2nd, Boyd MR.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " "Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.##Cyclotides as natural anti-HIV agents." DRAMP00800 GTACGESCYVLPCFTVGCTCTSSQCFKN 28 Cycloviolin-B (Plant defensin) P84638 Belongs to the cyclotide family Not found Leonia cymosa (Sacha uba) "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has anti-HIV activity. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-18;8-20;13-25." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=130 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys4 and Cys18, Cys8 and Cys20,Cys13 and Cys25." L [Ref.18008336]CEM-SS cells:IC50=560 nM. Not found 10813905##18008336 J Org Chem. 2000 Jan 14;65(1):124-128.##Biopolymers. 2008;90(1):51-60. "Hallock YF, Sowder RC 2nd, Pannell LK, Hughes CB, Johnson DG, Gulakowski R, Cardellina JH 2nd, Boyd MR.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " "Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.##Cyclotides as natural anti-HIV agents." DRAMP00801 GIPCGESCVFIPCLTTVAGCSCKNKVCYRN 30 Cycloviolin-C (Plant defensin) P84639 Belongs to the cyclotide family Not found Leonia cymosa (Sacha uba) "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has anti-HIV activity. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-20;8-22;13-27." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=130 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27." L [Ref.18008336]CEM-SS cells:IC50=560 nM. Not found 10813905##18008336 J Org Chem. 2000 Jan 14;65(1):124-128.##Biopolymers. 2008;90(1):51-60. "Hallock YF, Sowder RC 2nd, Pannell LK, Hughes CB, Johnson DG, Gulakowski R, Cardellina JH 2nd, Boyd MR.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " "Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.##Cyclotides as natural anti-HIV agents." DRAMP00802 GFPCGESCVFIPCISAAIGCSCKNKVCYRN 30 Cycloviolin-D (Plant defensin) P84640 Belongs to the cyclotide family Not found Leonia cymosa (Sacha uba) "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has anti-HIV activity. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-20; 8-22; 13-27." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=130 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27." L [Ref.18008336]CEM-SS cells:IC50=560 nM. Not found 10813905##18008336 J Org Chem. 2000 Jan 14;65(1):124-128.##Biopolymers. 2008;90(1):51-60. "Hallock YF, Sowder RC 2nd, Pannell LK, Hughes CB, Johnson DG, Gulakowski R, Cardellina JH 2nd, Boyd MR.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " "Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.##Cyclotides as natural anti-HIV agents." DRAMP00803 GDPTFCGETCRVIPVCTYSAALGCTCDDRSDGLCKRN 37 Palicourein (Cyclotides; Plants) P84645 Belongs to the cyclotide family Not found Palicourea condensata (Cappel) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure Palicourein has an atypical size and composition within one of the surface-exposed loops. 1R1F resolved by NMR. "Function: Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus. In vitro activity: Palicourein inhibits the cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 ?M and an IC50 value of 1.5 ?M. PTM: This is a cyclic peptide which may contain three disulfide bonds 6-24; 10-26; 16-34." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=100 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys1 and Cys19; Cys5 and Cys21; Cys11 and Cys28;hydrogen bonds between the oxygen atoms of the Glu3 carboxyl group and the backbone amides of residues Thr12, Thr13, and Ser14, and the side chain of Ser14. " L "[Ref.11430013] Cytotoxicity: human T-lymphoblastoid cell line (CEM-SS)(EC50=0.10 m, IC50=1.5 M) . ##[Ref.18008336]CEM-SS cells:IC50=1500 nM." Not found 11430013##14725768##18008336 J Nat Prod. 2001 Feb;64(2):249-250.##Structure. 2004 Jan;12(1):85-94.##Biopolymers. 2008;90(1):51-60. "Bokesch HR, Pannell LK, Cochran PK, Sowder RC 2nd, McKee TC, Boyd MR.##Barry DG, Daly NL, Bokesch HR, Gustafson KR, Craik DJ.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " A novel anti-HIV macrocyclic peptide from Palicourea condensata.##Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework.##Cyclotides as natural anti-HIV agents. DRAMP00816 GIPCGESCVWIPCISAAIGCSCKSKVCYRN 30 Cycloviolacin-O13 (Cyclotide c3; Plant defensin) Q5USN8 Belongs to the cyclotide family Voc3 Viola odorata (Sweet violet) "Antiviral,Insecticidal " Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has hemolytic activity. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-20; 8-22; 13-27." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=320 nM). [Ref:16872274] It has 50% hemolytic activity at 1.0 M and 75% hemolytic activity at 1.5 M against human type A red blood cells Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) Disulfide bonds between Cys4 and Cys20; Cys8 and Cys22; Cys13 and Cys27. L [Ref.18008336]CEM-SS cells:IC50=6400 nM. Not found 16872274##18008336 Biochem J. 2006 Nov 15;400(1):1-12.##Biopolymers. 2008;90(1):51-60. "Ireland DC, Colgrave ML, Craik DJ.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " "A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.##Cyclotides as natural anti-HIV agents." DRAMP00817 GSIPACGESCFKGKCYTPGCSCSKYPLCAKN 31 Cycloviolacin-O14 (Plant defensin) P85177 Belongs to the cyclotide family Not found Viola odorata (Sweet violet) "Antiviral,Insecticidal " Protein level Combine helix and strand structure Cycloviolacin O14 is shown to contain the CCK motif. 2GJ0 resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has hemolytic activity. PTM: This is a cyclic peptide which may contain three disulfide bonds 6-20; 10-22; 15-27." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=440 nM). [Ref:16872274] It has 3% hemolytic activity at 1.0 M and 13% hemolytic activity at 1.5 M against human type A red blood cells Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) Disulfide bonds between Cys6 and Cys20; Cys10 and Cys22; Cys15 and Cys27. L [Ref.18008336]CEM-SS cells:IC50=4800 nM. Not found 16872274##18008336 Biochem J. 2006 Nov 15;400(1):1-12.##Biopolymers. 2008;90(1):51-60. "Ireland DC, Colgrave ML, Craik DJ.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " "A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.##Cyclotides as natural anti-HIV agents." DRAMP00831 GLPVCGETCFGGTCNTPGCICDPWPVCTRN 30 Cycloviolacin-H3 (Plant defensin) P85232 Belongs to the cyclotide family Not found Viola hederacea (Australian violet) "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. PTM: This is a cyclic peptide which contains three disulfide bonds 4-20; 8-22; 13-27." Virus: HIV. No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys4 and Cys20; Cys8 and Cys22; Cys13 and Cys27. L No cytotoxicity information found Not found 10600388 J Mol Biol. 1999 Dec 17;294(5):1327-1336. "Craik DJ, Daly NL, Bond T, Waine C." Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. DRAMP00832 GIPCAESCVWIPCTVTALLGCSCSNNVCYN 30 Cycloviolacin-H4 (Plant defensin) P85234 Belongs to the cyclotide family Not found Viola hederacea (Australian violet) "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. PTM: This is a cyclic peptide which contains three disulfide bonds 4-20; 8-22; 13-27." No MICs found in DRAMP database [Ref.16441062] HD50=5.5 ?M against human type A red blood cells. Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys4 and Cys20; Cys8 and Cys22; Cys13 and Cys27. L No cytotoxicity information found Not found 10600388 J Mol Biol. 1999 Dec 17;294(5):1327-1336. "Craik DJ, Daly NL, Bond T, Waine C." Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. DRAMP00833 GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN 33 Cycloviolacin-Y1 (Plants) No entry found Belongs to the cyclotide family Not found Viola yedoensis (Chinese herb) "Antimicrobial, Antiviral" Not found Bridge Not found None Function: Has anti-HIV activity. PTM: Contains three disulfide bonds. "[Ref.18081258] Anti-HIV activity:EC50=1.2M, IC50>4.5M. ##NOTE:EC50 refers to the values for HIV-infected cell cultures, IC50 refers to the values for uninfected cell cultures.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=1210 nM)." [Ref.18081258] It has hemolytic activity. Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29. L [Ref.18008336]CEM-SS cells:IC50>4470 nM. Not found 18081258##18008336 J Nat Prod. 2008 Jan;71(1):47-52.##Biopolymers. 2008;90(1):51-60. "Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.##David C Ireland, Conan K L Wang, Jennifer A Wilson, Kirk R Gustafson, David J Craik" Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.##Cyclotides as natural anti-HIV agents DRAMP00834 GGTIFDCGESCFLGTCYTAGCSCGNWGLCYGTN 33 Cycloviolacin-Y2 (Plants) No entry found Belongs to the cyclotide family Not found Viola yedoensis (Chinese herb) "Antimicrobial, Antiviral" Not found Bridge Not found None Function: Has anti-HIV activity. PTM: Contains three disulfide bonds. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29. L No cytotoxicity information found Not found 18081258 J Nat Prod. 2008 Jan;71(1):47-52. "Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ." Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. DRAMP00835 GGTIFDCGETCFLGTCYTAGCSCGNWGLCYGTN 33 Cycloviolacin-Y3 (Plants) No entry found Belongs to the cyclotide family Not found Viola yedoensis (Chinese herb) "Antimicrobial, Antiviral" Not found Bridge Not found None Function: Has anti-HIV activity. PTM: Contains three disulfide bonds. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29. L No cytotoxicity information found Not found 18081258 J Nat Prod. 2008 Jan;71(1):47-52. "Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ." Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. DRAMP00836 GVPCGESCVFIPCITGVIGCSCSSNVCYLN 30 Cycloviolacin-Y4 (Plants) No entry found Belongs to the cyclotide family Not found Viola yedoensis (Chinese herb) "Antimicrobial, Antiviral" Not found Bridge Not found None Function: Has anti-HIV activity. Cycloviolacins Y4 is more hemolytic than cycloviolacin Y1. PTM: Contains three disulfide bonds. "[Ref.18618891]Effects: H. contortus( IC50=2.01M, IC99=6.73M) and T. colubriformis(IC50=2.27M, IC99=5.26M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=120 nM)." [Ref:18081258] HD50=9.3 M against human type A red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) Disulfide bonds between Cys4 and Cys20; Cys8 and Cys22; Cys13 and Cys27. L [Ref.18008336]CEM-SS cells:IC50=1720 nM. Not found 18081258##18008336##18618891 J Nat Prod. 2008 Jan;71(1):47-52.##Biopolymers. 2008;90(1):51-60.##Chembiochem. 2008 Aug 11;9(12):1939-45. doi: 10.1002/cbic.200800174. "Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.##David C Ireland, Conan K L Wang, Jennifer A Wilson, Kirk R Gustafson, David J Craik##Michelle L Colgrave, Andrew C Kotze, David C Ireland, Conan K Wang, David J Craik" Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.##Cyclotides as natural anti-HIV agents##The anthelmintic activity of the cyclotides: natural variants with enhanced activity DRAMP00837 GIPCAESCVWIPCTVTALVGCSCSDKVCYN 30 Cycloviolacin-Y5 (Plants) No entry found Belongs to the cyclotide family Not found Viola yedoensis (Chinese herb) "Antimicrobial, Antiviral" Not found Bridge Not found None "Function: Has anti-HIV activity. Cycloviolacin Y5 is the most hydrophobic of the cyclotides from V. yedoensis, and is more hemolytic than cycloviolacin Y1. PTM: Contains three disulfide bonds. " "[Ref.18618891]Effects: H. contortus( IC50=2.28M, IC99=22.24M) and T. colubriformis(IC50=2.40M, IC99=10.97M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=40 nM)." [Ref:18081258] HD50=8.7 M against human type A red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) Disulfide bonds between Cys4 and Cys21; Cys8 and Cys23; Cys13 and Cys28. L [Ref.18008336]CEM-SS cells:IC50=1760 nM. Not found 18081258##18008336##18618891 J Nat Prod. 2008 Jan;71(1):47-52.##Biopolymers. 2008;90(1):51-60.##Chembiochem. 2008 Aug 11;9(12):1939-45. doi: 10.1002/cbic.200800174. "Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.##David C Ireland, Conan K L Wang, Jennifer A Wilson, Kirk R Gustafson, David J Craik##Michelle L Colgrave, Andrew C Kotze, David C Ireland, Conan K Wang, David J Craik" Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.##Cyclotides as natural anti-HIV agents##The anthelmintic activity of the cyclotides: natural variants with enhanced activity DRAMP00863 GSVLNCGETCLLGTCYTTGCTCNKYRVCTKD 31 Kalata-B8 (Plant defensin) P85175 Belongs to the cyclotide family Not found Oldenlandia affinis "Antimicrobial, Antiviral" Protein level Beta strand (3 strands; 7 residues) Not found 2B38 resolved by NMR. "Function: Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus. Has no hemolytic activity. PTM: Kalata-B8 is a cyclic peptide which contains three disulfide bonds 6-20; 10-22; 15-28." [Ref.16207177]Virus: Human T-lymphoblast (CEM-SS) cells (EC50=2.5 ?M).##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=2500 nM). [Ref.20564013] It produced 7% hemolysis at the 62M. Cyclic Cyclization (N termini to C termini) Cyclization (C termini to N termini) Disulfide bonds between Cys6 and Cys20; Cys10 and Cys22; Cys15 and Cys28. L "[Ref.16207177] Kalata B8 inhibited the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells with an antiviral cytoprotective concentration (EC50) of approx. 2.5 M, while the cytotoxic concentration (IC50) was >11 M. ##[Ref.18008336]CEM-SS cells:IC50>11000 nM." Not found 18008336##16207177##17534989 Biopolymers. 2008;90(1):51-60.##Biochem J. 2006 Feb 1;393(Pt 3):619-626.##Chembiochem. 2007 Jun 18;8(9):1001-1011. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Daly NL, Clark RJ, Plan MR, Craik DJ.##Plan MR, G?ransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ." "Cyclotides as natural anti-HIV agents.##Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif.##The cyclotide fingerprint in Oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides." DRAMP00875 SISCGESCAMISFCFTEVIGCSCKNKVCYLN 31 Leaf cyclotide 1 (Vhl-1; Plant defensin) P84522 Belongs to the cyclotide family Not found Viola hederacea (Australian violet) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure "Vhl-1 adopts a compact and well defined structure including a distorted triple-stranded beta-sheet, a short 3(10) helical segment and several turns. It is stabilized by three disulfide bonds, which, together with backbone segments, form a cyclic cystine knot motif. The three-disulfide bonds are almost completely buried into the protein core, and the six cysteines contribute only 3.8% to the molecular surface." 1ZA8 resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has anti-human immunodeficiency virus activity. Tissue specificity: Expressed in leaves. PTM: Vhl-1 is a cyclic peptide which contains three disulfide bonds 4-21; 8-23; 14-28." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=870 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) Disulfide bonds between Cys4 and Cys21; Cys8 and Cys23; Cys13 and Cys28. L No cytotoxicity information found in the reference(s) presented Not found 18008336##15824119 Biopolymers. 2008;90(1):51-60.##J Biol Chem. 2005 Jun 10;280(23):22395-22405. "Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. ##Chen B, Colgrave ML, Daly NL, Rosengren KJ, Gustafson KR, Craik DJ." "Cyclotides as natural anti-HIV agents.##Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide." DRAMP00876 GLPVCGETCFTGTCYTNGCTCDPWPVCTRN 30 Leaf cyclotide 2 (Vhl-2; Plant defensin) P85231 Belongs to the cyclotide family Not found Viola hederacea (Australian violet) "Antimicrobial, Antiviral" Protein level Beta strand (5 strands; 6 residues) "Analysis of surface hydrophobicity and haemolytic activity for a range of cyclotides indicates a correlation between them, with increasing hydrophobicity resulting in increased haemolytic activity." 2KUK resolved by NMR. "Function: Probably participates in a plant defense mechanism. Has hemolytic activity. Tissue specificity: Expressed in leaves. PTM: This is a cyclic peptide which contains three disulfide bonds 5-19; 9-21; 14-27." [Ref.15824119]Virus: HIV(EC50= 0.87 M) [Ref:15824119]Has hemolytic activity Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet cell membrabce 15824119##Pubmed ID is not available J Biol Chem. 2005 Jun 10;280(23):22395-22405.##Aust. J. Chem. 2010;63:771-778. "Chen B, Colgrave ML, Daly NL, Rosengren KJ, Gustafson KR, Craik DJ.##Daly NL, Chen B, Nguyencong P, Craik DJ." "Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.##Structure and activity of the leaf-specific cyclotide vhl-2." DRAMP00879 GIPCGESCVFIPCITSVAGCSCKSKVCYRN 30 Circulin-C (CIRC; Plant defensin) P84641 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-20; 8-22; 13-27." [Ref.10691702]Virus: HIV-1 (EC50= 50-275 nM).##NOTE: EC50 = concentration that is 50% effective.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=50-275 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27." L No cytotoxicity information found in the reference(s) presented Not found 10691702##18008336 J Nat Prod. 2000 Feb;63(2):176-178.##Biopolymers. 2008;90(1):51-60. "Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " New circulin macrocyclic polypeptides from Chassalia parvifolia.##Cyclotides as natural anti-HIV agents. DRAMP00880 KIPCGESCVWIPCVTSIFNCKCKENKVCYHD 31 Circulin-D (CIRD; Plant defensin) P84642 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-20; 8-22; 13-27." [Ref.10691702]Virus: HIV-1 (EC50= 50-275 nM).##NOTE: EC50 = concentration that is 50% effective.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=50-275 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27." L No cytotoxicity information found in the reference(s) presented Not found 10691702##18008336 J Nat Prod. 2000 Feb;63(2):176-178.##Biopolymers. 2008;90(1):51-60. "Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " New circulin macrocyclic polypeptides from Chassalia parvifolia.##Cyclotides as natural anti-HIV agents. DRAMP00881 KIPCGESCVWIPCLTSVFNCKCENKVCYHD 30 Circulin-E (CIRE; Plant defensin) P84643 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-20; 8-22; 13-27." [Ref.10691702]Virus: HIV-1 (EC50= 50-275 nM).##NOTE: EC50 = concentration that is 50% effective.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=50-275 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27." L No cytotoxicity information found in the reference(s) presented Not found 10691702##18008336 J Nat Prod. 2000 Feb;63(2):176-178.##Biopolymers. 2008;90(1):51-60. "Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " New circulin macrocyclic polypeptides from Chassalia parvifolia.##Cyclotides as natural anti-HIV agents. DRAMP00882 KVCYRAIPCGESCVWIPCISAAIGCSCKN 29 Circulin-F (CIRF; Plant defensin) P84644 Belongs to the cyclotide family Not found Chassalia parviflora "Antimicrobial, Antiviral" Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus. PTM: This is a cyclic peptide which may contain three disulfide bonds 4-20; 8-22; 13-27." [Ref.10691702]Virus: HIV-1 (EC50= 50-275 nM).##NOTE: EC50 = concentration that is 50% effective.##[Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=50-275 nM). No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) "Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27." L No cytotoxicity information found in the reference(s) presented Not found 10691702##18008336 J Nat Prod. 2000 Feb;63(2):176-178.##Biopolymers. 2008;90(1):51-60. "Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " New circulin macrocyclic polypeptides from Chassalia parvifolia.##Cyclotides as natural anti-HIV agents. DRAMP00936 DVSFRLSGATSKKKVYFISNLRKALPNEKKLYDIPLVRSSXSGSK 45 Ribosome-inactivating protein TAP-29 (rRNA N-glycosidase; Plant defensin) P23029 Belongs to the ribosome-inactivating protein family (Type 1 RIP subfamily) Not found Trichosanthes kirilowii (Chinese snake gourd) (Chinese cucumber) "Antiviral, Cytotoxic, Antimicrobial" Protein level Not found Not found None "Function: Capable of inhibiting HIV-1 infection and replication. It inactivates eukaryotic 60S ribosomal subunits. Catalytic activity: Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 1713684 Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6570-4. "Lee-Huang S, Huang PL, Kung HF, Li BQ, Huang PL, Huang P, Huang HI, Chen HC." TAP 29: an anti-human immunodeficiency virus protein from Trichosanthes kirilowii that is nontoxic to intact cells. DRAMP00952 KSCCPNTTGRNIYNTCRLTGSSRETCAKLSGCKIISASTCPSNYPK 46 Viscotoxin A1 (Plant defensin) D0VWT3 Not found Not found Viscum album (European mistletoe) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Combine helix and strand structure Not found 3C8P resolved by X-ray. Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18703848 Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):985-992. "Pal A, Debreczeni JE, Sevvana M, Gruene T, Kahle B, Zeeck A, Sheldrick GM." Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone. DRAMP01000 YQCGQGG 7 Ascalin (Plants) P84071 Not found Not found Allium cepa var. aggregatum (shallot) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None "Function: Has antifungal activity against Botrytis cinerea. Inhibits HIV-1 reverse transcriptase. Miscellaneous: Inhibits HIV-1 reverse transcriptase with an IC50 of 10 ?M." "Botrytis cinerea, HIV-1 reverse transcriptase (IC50=10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12126728 Peptides. 2002 Jun;23(6):1025-1029. "Wang HX, Ng TB." "Ascalin, a new anti-fungal peptide with human immunodeficiency virus type 1 reverse transcriptase-inhibiting activity from shallot bulbs." DRAMP01003 KTCENLADDY 10 Gymnin (Plants) P84200 Not found Not found Gymnocladus chinensis "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Function: Exerts antifungal activity. Has weak mitogenic activity against murine splenocytes. Displays antiproliferative activity on a human hepatoma cell line and mouse leukemia cell lines. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase. "Fungi: Fusarium oxysporum (IC50=2 ?M), Mycosphaerella arachidicola (IC50=10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14499273 Peptides. 2003 Jul;24(7):963-968. "Wong JH, Ng TB." "Gymnin, a potent defensin-like antifungal peptide from the Yunnan bean (Gymnocladus chinensis Baill)." DRAMP01005 VKSTGRADDDLAVKTKYLPP 20 Cicerarin (Plant defensin) P83986 Not found Not found Cicer arietinum (chickpea) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Function: Has antifungal activity. Also inhibits HIV-1 reverse transcriptase. "Fungi: Botrytis cinerea (IC50=20.6 ?M), Mycosphaerella arachidicola (IC50=15.3 ?M), Pseudocercospora piricola (IC50=8.2 ?M).##Virus: HIV-1 RT (IC50=87.5 ?M)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12895650 Peptides. 2003 May;24(5):659-663. "Chu KT, Liu KH, Ng TB." "Cicerarin, a novel antifungal peptide from the green chickpea." DRAMP01010 KTCENLADTFRGPCFATSNC 20 Lunatusin (Plants) No entry found Not found Not found Phaseolus lunatus L.(Chinese lima bean) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal" Not found Not found Not found None Function: It also inhibited proliferation in the breast cancer cell line MCF-7. Lunatusin reduced the activity of HIV-1 reverse transcriptase and it also inhibited translation in a cell-free rabbit reticulocyte lysate system. Its anti-fungal activity was "Fungi: Fusarium oxysporum, Mycosphaerella arachidicola and Botrytis cinerea.##Gram-positive bacteria: Bacillus megaterium, Bacillus subtilis;##Gram-negative bacteria: Proteus vulgaris, Mycobacterium phlei." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16269344 Peptides. 2005 Nov;26(11):2086-2092. "Wong JH, Ng TB." "Lunatusin, a trypsin-stable antimicrobial peptide from lima beans (Phaseolus lunatus L.)." DRAMP01067 KQTENLADTY 10 Coccinin (Plant defensin) P84785 Belongs to the DEFL family Not found Phaseolus coccineus (Scarlet runner bean) (Phaseolus multiflorus) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Function: Has strong antifungal activity. Inhibits the proliferation of leukemia cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase (IC50=41 ?M). Lacks mitogenic activity towards murine splenocytes. "Fungi: Fusarium oxysporum (IC50=817 ?M), Mycosphaerella arachidicola (IC50=755 ?M), Physalospora piricola (IC50=894 ?M), Rhizoctomia solani (IC50=1342 ?M), Botrytis cinerea (IC50=1095 ?M), Coprinus comatus (IC50=1227 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15572193 Peptides. 2004 Dec;25(12):2063-2068. "Ngai PH, Ng TB." "Coccinin, an antifungal peptide with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from large scarlet runner beans." DRAMP01084 ILGAILPLVSGLLSNKL 17 "Alyteserin-2b (toads, amphibians, animals)" No entry found Not found Not found Alytes obstetricans (European midwife toad) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Function: Amtimicrobial peptide. (By similarity) No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19463738 Peptides. 2009 Jun;30(6):1069-1073. "Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01086 ILGAILPLVSGLLSSKL 17 "Alyteserin-2c (toads, amphibians, animals)" No entry found Not found Not found Alytes obstetricans (European midwife toad) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Function: Amtimicrobial peptide. (By similarity) No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19463738 Peptides. 2009 Jun;30(6):1069-1073. "Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01087 GLKDIFKAGLGSLVKNIAAHVAN 23 "Alyteserin-1d (toads, amphibians, animals)" No entry found Not found Not found Alytes obstetricans (European midwife toad) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Function: Amtimicrobial peptide. (By similarity) No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19463738 Peptides. 2009 Jun;30(6):1069-1073. "Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC." The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). DRAMP01161 GWFDVVKHIASAV 13 "Uperin-7.1 (Frogs, amphibians, animals)" P82050 Not found Not found Litoria ewingi (Brown tree frog) (Ewing's tree frog) "Antimicrobial, Antibacterial, Anti-Gram+, Antiviral" Protein level Not found Not found None "Function: Uperin 7.1 shows antibacterial activity against L. lactis. Uperin 7.1.1 is inactive. Tissue specificity: Expressed by the skin dorsal glands." "Gram-positive bacteria: Streptococcus uberis, Lactococcus lactis." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Aust. J. Chem. 1997; 50:889-894. "Steinborner ST, Bowie JH, Tyler MJ, Wallace JC." "An unusual combination of peptides from the skin glands of Ewing's tree frog, Litoria ewingi. Sequence determination and antimicrobial activity." DRAMP01225 GIFPKIIGKGIVNGIKSLAKGVGMKVFKAGLNNIGNTGCNNRDEC 45 "Palustrin-3AR (Frogs, amphibians, animals)" No entry found Not found Not found Rana areolata (North American crawfish frog) "Antimicrobial, Antibacterial, Antiviral" Not found Not found Not found None This peptide could inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). No MICs found in DRAMP database [Ref:12429503] HC50=200 ?M against human erythrocytes Cyclic Free Cyclization (Cys39 and Cys45) Disulfide bond between Cys39 and Cys45. L No cytotoxicity information found Not found 12429503 Biochim Biophys Acta. 2002 Nov 19;1601(1):55-63. "Ali MF, Lips KR, Knoop FC, Fritzsch B, Miller C, Conlon JM." "Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata." DRAMP01366 GLLGLLGSVVSHVVPAIVGHF 21 "Maculatin-1.3 (frog, amphibia, animals)" No entry found Not found Not found Litoria eucnemis (Australian anurans) "Antimicrobial, Antibacterial, Antiviral" Not found Not found Not found None Function: Has antiviral activity. The peptide is HIV inhibitory (EC50=4 ?M). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15203252 Peptides. 2004; 25: 1035-1054. "Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE." "Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance." DRAMP01551 GLLGVLGSVAKHVLPHVVPVIAEHL 25 "Caerin-1.2 (Frogs, amphibians, animals)" P56227 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria caerulea (Australian frog) "Antimicrobial, Antibacterial,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin parotoid and/or rostral glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." [Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 22 ?M." Not found 26026377##PubMed ID is not available Peptides. 2015 Sep;71:296-303. ##J. Chem. Res. 1993; 138: 910-936. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ." Inhibition of HIV infection by caerin 1 antimicrobial peptides.##Peptides from Australian frogs. The structures of the caerins from Litoria caerula. DRAMP01556 GLFSVLGAVAKHVLPHVVPVIAEKL 25 "Caerin-1.6 (Frogs, amphibians, animals)" "P62546, P56231, P81249, P62547" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria xanthomera (Orange-thighed frog) (Litoria chloris) "Antimicrobial, Antibacterial,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin dorsal glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility By similarity. PTM: C-terminal amidation." [Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L "[Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 10 ?M." Cell membrane 26026377##9230483##9204574##9516047 Peptides. 2015 Sep;71:296-303. ##J Pept Sci. 1997 May-Jun;3(3):181-185.##Rapid Commun Mass Spectrom. 1997;11(9):997-1000.##J Pept Res. 1998 Feb;51(2):121-126. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Steinborner ST, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ, Ramsay SL.##Steinborner ST, Waugh RJ, Bowie JH, Tyler MJ.##Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ." Inhibition of HIV infection by caerin 1 antimicrobial peptides.##New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.##New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera. Part 2. Sequence determination using mass spectrometry and associated techniques.##New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria. DRAMP01557 GLFKVLGSVAKHLLPHVAPVIAEKL 25 "Caerin-1.7 (Frogs, amphibians, animals)" "P62548, P62549, P56232, P81250" Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria xanthomera (Orange-thighed frog) (Litoria chloris) "Antimicrobial, Antibacterial,Antiviral" Protein level Not found Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin dorsal glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility By similarity. PTM: C-terminal amidation." [Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation Free L [Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 12.5 ?M. Cell membrane 26026377##9230483##9204574##9516047 Peptides. 2015 Sep;71:296-303. ##J Pept Sci. 1997 May-Jun;3(3):181-185.##Rapid Commun Mass Spectrom. 1997;11(9):997-1000.##J Pept Res. 1998 Feb;51(2):121-126. "VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.##Steinborner ST, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ, Ramsay SL.##Steinborner ST, Waugh RJ, Bowie JH, Tyler MJ.##Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ." Inhibition of HIV infection by caerin 1 antimicrobial peptides.##New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.##New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera. Part 2. Sequence determination using mass spectrometry and associated techniques.##New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria. DRAMP01559 GLFKVLGSVAKHLLPHVVPVIAEKL 25 "Caerin-1.8 (Frogs, amphibians, animals)" P81251 Belongs to the frog skin active peptide family (Caerin subfamily) Not found Litoria chloris (Blue-thighed frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Alpha helix Not found None "Function: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. Tissue specificity: Expressed by the skin dorsal glands. Domain: Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity). PTM: C-terminal amidation." Litoria chloris No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9516047 J Pept Res. 1998 Feb;51(2):121-126. "Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ." New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria. DRAMP01629 GWMSKIASGIGTFLSGVQQG 20 "Phylloxin-S1 (Frogs, amphibians, animals)" No entry found Belongs to the Phyllomedusinae subfamily Not found Phyllomedusa sauvagii (Waxy Monkey Leaf Frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18644413 Peptides. 2008 Nov;29(11):2074-2082. "Amiche M, Ladram A, Nicolas P." A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. DRAMP01630 AVWKDFLKNIGKAAGKAVLNSVTDMVNE 28 "Dermaseptin-LI1 (Frogs, amphibians, animals)" No entry found Not found Not found Phyllomedusa hypochondrialis (Orange legged leaf frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18644413 Peptides. 2008 Nov;29(11):2074-2082. "Amiche M, Ladram A, Nicolas P." A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. DRAMP01631 GLWKSLLKNVGKAAGKAALNAVTDMVNQ 28 "Dermaseptin-S7 (Frogs, amphibians, animals)" No entry found Not found Not found Phyllomedusa sauvagei (Sauvage's leaf frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14599725 Regul Pept. 2003 Nov 15;116(1-3):139-146. "Chen T, Tang L, Shaw C." Identification of three novel Phyllomedusa sauvagei dermaseptins (sVI-sVIII) by cloning from a skin secretion-derived cDNA library. DRAMP01632 ALWKTMLKKLGTVALHAGKAALGAAADTISQ 31 "Dermaseptin-S8 (Frogs, amphibians, animals)" No entry found Not found Not found Phyllomedusa sauvagei (Sauvage's leaf frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Alpha helix Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 14599725 Regul Pept. 2003 Nov 15;116(1-3):139-146. "Chen T, Tang L, Shaw C." Identification of three novel Phyllomedusa sauvagei dermaseptins (sVI-sVIII) by cloning from a skin secretion-derived cDNA library. DRAMP01654 GLWSKIKEAGKAVLTAAGKAALGAVSDAV 29 "Dermaseptin-B8 (Frogs, amphibians, animals)" No entry found Not found Not found Phyllomedusa bicolor (Two-colored leaf frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9305726 FEBS Lett. 1997 Sep 1;414(1):27-32. "Vouille V, Amiche M, Nicolas P." "Structure of genes for dermaseptins B, antimicrobial peptides from frog skin. Exon 1-encoded prepropeptide is conserved in genes for peptides of highly different structures and activities." DRAMP01671 ALWMTLLKKVLKAAAKALNAVLVGANA 27 "Dermaseptin-4 (DS IV; Dermaseptin-S4, DS4; Frogs, amphibians, animals)" P80280 Belongs to the frog skin active peptide family (Dermaseptin subfamily) Not found Phyllomedusa sauvagei (Sauvage's leaf frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Combine strand and Turn structure Not found None "Function: Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1. Probably acts by disturbing membrane functions with its amphipathic structure. Has strong hemolytic activity. Does not bind to P. falciparum infected erythrocytes, but accumulates within the parasite. Tissue specificity: Expressed by the skin glands. Pharmaceutical use: Derivatives of this peptide may be used as therapeutic agents to treat bacterial infections and malaria, and to prevent infection by herpes simplex virus type 1 and HIV-1." "[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1" [Ref:11850249]IC50=20 M against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet healthy erythrocytes (this binding is receptor independent). 8306981##11850249##9395500 Eur J Biochem. 1994 Jan 15;219(1-2):145-154.##Antimicrob Agents Chemother. 2002 Mar;46(3):689-694.##J Biol Chem. 1997 Dec 12;272(50):31609-31616. "Mor A, Nicolas P.##Navon-Venezia S, Feder R, Gaidukov L, Carmeli Y, Mor A.##Ghosh JK, Shaool D, Guillaud P, Cic??ron L, Mazier D, Kustanovich I, Shai Y, Mor A." Isolation and structure of novel defensive peptides from frog skin.##Antibacterial properties of dermaseptin S4 derivatives with in vivo activity.##Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis. DRAMP01713 VHLEEILLLLFFLGTISLSLCEEERDADEEENEVSGYAANVNVKRCGYKHGRANCGRG 58 "OGA1 antimicrobial peptide (Frogs, amphibians, animals)" B5L172 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Transcript level Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases "Wang X, Lai R." Odorrana grahmi antimicrobial peptide cDNA sequences. DRAMP01714 MFTMKKSLLLLFFLGTINLSFCQEETNAEEERRDEEVAKMEEIKRGLLSGPRCGEESTMWT 61 "OGF2 antimicrobial peptide (Frogs, amphibians, animals)" B5L190 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Homology Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases "Wang X, Lai R." Odorrana grahmi antimicrobial peptide cDNA sequences. DRAMP01715 MFTLKKPLLLLFFLGTINLSLCQDETNAEEERRDEEVVKMEEIKRGLLSGILGAGKHIVCGLTGCAKA 68 "OGG1 antimicrobial peptide (Frogs, amphibians, animals)" B5L183 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Homology Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases "Wang X, Lai R." Odorrana grahmi antimicrobial peptide cDNA sequences. DRAMP01716 MFTLKKSLLLLFFLGTINLSLCQDVTNAEEERRDEEVAKMEEIKRGLLRPPRCGEAYSMWT 61 "OGF1 antimicrobial peptide (Frogs, amphibians, animals)" B5L180 Not found Not found Odorrana grahami (Yunnanfu frog) (Rana grahami) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Homology Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases "Wang X, Lai R." Odorrana grahmi antimicrobial peptide cDNA sequences. DRAMP01985 GLWDTIKQAGKKIFLSVLDKIRCKVAGGC 29 "Brevinin-2HS1 (Frogs, amphibians, animals)" No entry found Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Huia schmackeri (Chinese piebald odorous frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Not found Not found None "Function: Antimicrobial peptide homologs. Tissue specificity: Expressed by the skin glands." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18423796 Peptides. 2008 Aug;29(8):1456-1460. "Quan Z, Zhou M, Chen W, Chen T, Walker B, Shaw C." Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors. DRAMP01111 SIGAKILGGVKTFFKGALKELASTYLQ 27 "Maximin-5 (Toads, amphibians, animals)" "P83084, Q58T60, Q58T61" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. No amidation at the C-terminus. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacterium: Klebsiella pneumoniae (MIC=3.6 g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.6 g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.2 g/ml), Bacillus megatherium (MIC=12 g/ml), Bacillus dysenteriae (MIC=12 g/ml).##Fungi: Candida albicans ATCC 2002 (MIC=1.2 g/ml), Aspergillus flavus IFFI 4015 (MIC=12 g/ml), Penicillium uticale IFFI 2001 (MIC=12 g/ml);##Virus: HIV-1 (IC50=34.4 g/ml, EC50=39.8 g/ml);##Cancer cell lines: C8166 (IC50=34.4 g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP01110 GIGGVLLSAGKAALKGLAKVLAEKYAN 27 "Maximin-4 (Toads, amphibians, animals)" "P83083, Q58T42, Q58T44, Q58T52, Q58T62, Q58T77, Q58T79" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. 2MHW resolved by NMR "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2.7 ?g/ml), Klebsiella pneumoniae (MIC=15 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=2.7 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=2.7 ?g/ml), Bacillus megatherium (MIC=1.5 ?g/ml), Bacillus dysenteriae (MIC=2.7 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=15 ?g/ml);##Virus: HIV-1 (IC50=24.2 ?g/ml, EC50=21.9 ?g/ml);##Cancer cell lines: C8166 (IC50=24.2 ?g/ml), Molt-4 (IC50=35.4 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP01109 GIGGKILSGLKTALKGAAKELASTYLH 27 "Maximin-3 (Toads, amphibians, animals)" "P83082, Q58T40, Q58T43, Q58T46, Q58T48, Q58T64, Q58T65, Q58T68, Q58T69" Belongs to the bombinin family Not found Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral, Anti-cancer" Protein level Not found Maximins are linear cationic peptides and easy to form membrane pore and they may induce a detergent-type disruption of sperm membrane like in the case of magainins. None "Function: Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Has little hemolytic activity. Possess a significant cytotoxicity against tumor cell lines. Possess a significant anti-HIV activity. High spermicidal activity. No amidation at the C-terminus. Toxic dose: LD50 is 4.3 mg/kg by intraperitoneal injection into mice. Tissue specificity: Expressed by the skin glands." "[Ref.11835991] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.9 ?g/ml), Klebsiella pneumoniae (MIC=3.1 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.1 ?g/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=1.5 ?g/ml), Bacillus megatherium (MIC=0.9 ?g/ml), Bacillus dysenteriae (MIC=0.9 ?g/ml);##Yeast: Candida albicans ATCC 2002 (MIC=15 ?g/ml);##Virus: HIV-1 (IC50=11.4 ?g/ml, EC50=1.5 ?g/ml);##Cancer cell lines: C8166 (IC50=11.4 ?g/ml), Molt-4 (IC50=25.2 ?g/ml), BIU-87 (IC50=28 ?g/ml), T24 (IC50=18 ?g/ml)." [Ref:11835991]Little hemolytic activity at 50 g/ml against red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 15770703##11835991 Eur J Immunol. 2005 Apr;35(4):1220-9.##Peptides. 2002 Mar;23(3):427-435. "Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.##Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y." Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.##Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. DRAMP18273 KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWKS 43 Enterocin CRL35 (Bacteriocin) No entry found Belongs to the class IIa bacteriocin munA Enterococcus mundtii CRL35 "Antibacterial, Antiviral, Anti-Gram+, Antimicrobial" Bridge Not found None "Both biological activities, antibacterial and antiviral, were destroyed after incubation of the enterocin with protease IV or by raising the pH." "Gram-positive, virus(certain)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 10493605##11040432 Int J Antimicrob Agents. 1999 Aug;12(4):293-9.##FEMS Microbiol Lett. 2000 Nov 1;192(1):79-83. "Wachsman MB, Far" Antiviral activity of enterocin CRL35 against herpesviruses.##Effect of enterocin CRL35 on Listeria monocytogenes cell membrane. DRAMP02332 FIHHIFRGIVHAGRSIGRFLTG 22 "Piscidin-3 (Pis-3; fish, chordates, animals)" P0C006 Belongs to the pleurocidin family Not found Morone chrysops x Morone saxatilis (white bass x striped sea-bass) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Not found Not found None "Function: Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has hemolytic activity. Tissue specificity: Mast cells in gill, skin and gut, and in lining blood vessels in the viscera." [Swiss_Prot Entry P0C006]broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria [Ref.11713517]5% hemolytic activity at 100 g/mL against human erythrocytes Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11713517 Nature. 2001 Nov 15;414(6861):268-269. "Silphaduang U, Noga EJ." Peptide antibiotics in mast cells of fish. DRAMP02333 FFRHLFRGAKAIFRGARQGWRAHKVVSRYRNRDVPETDNNQEEP 44 "Piscidin-4 (Pis-4; fish, chordates, animals)" E3UVF6 Belongs to the pleurocidin family Not found Morone chrysops x Morone saxatilis (white bass x striped sea-bass) "Antimicrobial, Antibacterial, Antiviral" Predicted Not found Not found None "Function: Piscidin 4 demonstrates potent, broad-spectrum, antibacterial activity against a number of fish and human pathogens, including multi-drug resistant bacteria. Sequence similarity: It has considerable (to >65%) N-terminal sequence homology to piscidins 1-3." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19266617 Comp Biochem Physiol B Biochem Mol Biol. 2009 Apr;152(4):299-305. "Noga EJ, Silphaduang U, Park NG, Seo JK, Stephenson J, Kozlowicz S." "Piscidin 4, a novel member of the piscidin family of antimicrobial peptides." DRAMP02523 MLHLVVYDISDDGSRARLAKLLEKFGLQRVQYSAFRGELNPNDREVLARQVGKFVRDDRDCIFIIPLCQRCSSTAIVISNTGVELVKEKGVEFV 94 CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin) O28403 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas21 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM9628 / NBRC 100126) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: CRISPR is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 9389475##18482976 Nature. 1997 Nov 27;390(6658):364-370.##J Biol Chem. 2008 Jul 18;283(29):20361-71. "Klenk HP, Clayton RA, Tomb JF, White O, Nelson KE, Ketchum KA, Dodson RJ, Gwinn M, Hickey EK, Peterson JD, Richardson DL, Kerlavage AR, Graham DE, Kyrpides NC, Fleischmann RD, Quackenbush J, Lee NH, Sutton GG, Gill S, Kirkness EF, Dougherty BA, McKenney K, Adams MD, Loftus B, et al.##Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Ya" "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.##A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats." DRAMP02524 MFYLISYDISVDQRRLKIAKLLEGYGQRVLESVFECDLELPAYRQLRQKLNRLIKDEEGDRLRIYRLCASCREQIEIIGDGPPPETSQDIYII 93 CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin) A9WEP1 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-1 Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases "Copeland A, Lucas S, Lapidus, Barry K, Glavina del Rio T, Hammon N, Israni S, Dalin E, Tice H, Pitluck S, Chertkov O, Brettin T, Bruce D, Detter JC, Han C, Schmutz J, Larimer F, Land M, Hauser L, Kyrpides N, Mikhailova N, Pierson BK, Blankenship RE, Richardson P." Complete sequence of Chloroflexus aurantiacus J-10-fl. DRAMP02525 MTVKHLIVCYDVEKTKDRNKVIKVLEYYGLIRVQYSVFMGSLTETRLHQMNARIKREFTKPSIKILVIEVCNACMERALLVHEELPKVNRQFEVI 95 CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin) Q2FL79 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-1 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC100397 / JF-1) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases "Copeland A, Lucas S, Lapidus A, Barry K, Detter JC, Glavina T, Hammon N, Israni S, Pitluck S, Brettin T, Bruce D, Han C, Tapia R, Gilna P, Kiss H, Schmutz J, Larimer F, Land M, Kyrpides N, Ivanova N, McInerney MJ, Brockman F, Culley D, Ferry JG, Gunsalus RP, Morrison M, Plugge C, Scholten J, Stams AJM, Boone DR, Richardson P." Complete sequence of Methanospirillum hungatei JF-1. DRAMP02526 MIWLAVYDIEDDGERAKASAILQAWGFVRVQRSFYVGRMPRGKAADLLKILQRHVKSGHIALIPITDELLAKALELGRPPYAPLKPPKYAQIYVV 95 CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin) Q8ZZU2 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-1 Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630/ NBRC 100827) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 11792869 Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):984-989. "Fitz-Gibbon ST, Ladner H, Kim UJ, Stetter KO, Simon MI, Miller JH." Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum. DRAMP02527 MLYLIIYDVPATKAGNKRRTRLFDLLSGYGKWRQFSVFECFLSVKQFAKLQTAMEKLIKLDEDAVCIYVLDENTVQRTITYGTPQPEKPGSIII 94 CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin) Q6ZEI1 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-1 Synechocystis sp. (strain PCC 6803 / Kazusa) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 14686584 DNA Res. 2003 Oct 31;10(5):221-228. "Kaneko T, Nakamura Y, Sasamoto S, Watanabe A, Kohara M, Matsumoto M, Shimpo S, Yamada M, Tabata S." "Structural analysis of four large plasmids harboring in a unicellular cyanobacterium, Synechocystis sp. PCC 6803." DRAMP02528 MRELYLVIAYDTPDDRRRARLAKLLKGFGERRQYSVFEARLTREQWAHLKGKLEALVNKEEDVLAVYFLPPEAVGRTWRIGHEGLKRLEDPDFV 94 CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin) Q745W0 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2a Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 15064768 Nat Biotechnol. 2004 May;22(5):547-553. "Henne A, Brggemann H, Raasch C, Wiezer A, Hartsch T, Liesegang H, Johann A, Lienard T, Gohl O, Martinez-Arias R, Jacobi C, Starkuviene V, Schlenczeck S, Dencker S, Huber R, Klenk HP, Kramer W, Merkl R, Gottschalk G, Fritz HJ." The genome sequence of the extreme thermophile Thermus thermophilus. DRAMP02529 MRVLYIIAYDITDARRLGQIRYFLKGYSTGGQKSVYECFLEREELKFIISKIKRLINPNEDRVHIFRIDGRSKVITLGIAVPPIDPEYFYIG 92 CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin) B5YJS1 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-1 Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 /YP87) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases "Dodson R.J, Durkin A.S, Wu M, Eisen J, Sutton G." The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87. DRAMP02530 MVVIVYVIVAYDVNVERVNRVKKFLRRYLNWVQNSLFEGELSSADLEEVKMGLREIINEDEDMVVIYRFRSADAFKREVMGIEKGLGGEEVI 92 CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin) O30237 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas22 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM9628 / NBRC 100126) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 9389475 Nature. 1997 Nov 27;390(6658):364-370. "Klenk HP, Clayton RA, Tomb JF, White O, Nelson KE, Ketchum KA, Dodson RJ, Gwinn M, Hickey EK, Peterson JD, Richardson DL, Kerlavage AR, Graham DE, Kyrpides NC, Fleischmann RD, Quackenbush J, Lee NH, Sutton GG, Gill S, Kirkness EF, Dougherty BA, McKenney K, Adams MD, Loftus B, et al." "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." DRAMP02531 MQCLVIYDIPNDRARQRVADACLDYGLQRIQYSAFAGNLSRTHQRALFGEITRRVKGHTANVQLFVFDSKTWSDRRILEQQYDDA 85 CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin) A9WFZ7 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-2 Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases "Copeland A, Lucas S, Lapidus, Barry K, Glavina del Rio T, Hammon N, Israni S, Dalin E, Tice H, Pitluck S, Chertkov O, Brettin T, Bruce D, Detter JC, Han C, Schmutz J, Larimer F, Land M, Hauser L, Kyrpides N, Mikhailova N, Pierson BK, Blankenship RE, Richardson P." Complete sequence of Chloroflexus aurantiacus J-10-fl. DRAMP02532 MVRLVITYDIRKDKIRNKLFRLLERYGAWKQYSVFELEINPVHKVELFHSIADLIEDTDRVRIYDLCERCQGKITELGEVSPDKMQVVI 89 CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin) Q2FQQ4 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-2 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC100397 / JF-1) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases "Copeland A, Lucas S, Lapidus A, Barry K, Detter JC, Glavina T, Hammon N, Israni S, Pitluck S, Brettin T, Bruce D, Han C, Tapia R, Gilna P, Kiss H, Schmutz J, Larimer F, Land M, Kyrpides N, Ivanova N, McInerney MJ, Brockman F, Culley D, Ferry JG, Gunsalus RP, Morrison M, Plugge C, Scholten J, Stams AJM, Boone DR, Richardson P." Complete sequence of Methanospirillum hungatei JF-1. DRAMP02533 MILIYDINTEDNDGKRRLVKIMKTSRKYLSHVQKSVFEGDITEGQISLLKKEIMAIVNMKKDFVIIYSLRDGVKLNREILTDTPDPTDNFL 91 CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin) Q2RHR2 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-2 Moorella thermoacetica (strain ATCC 39073) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 18631365 Environ Microbiol. 2008 Oct;10(10):2550-2573. "Pierce E, Xie G, Barabote RD, Saunders E, Han CS, Detter JC, Richardson P, Brettin TS, Das A, Ljungdahl LG, Ragsdale SW." The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum). DRAMP02534 MYVVVAYDITEDEVRNKVADALKAYGLERIQRSVFVGRINPALLKDLVERLKRITKGANADITIFKVDRRAIDTAIRIGPPPPARKNVDLY 91 CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin) Q8ZZL9 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-2 Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630/ NBRC 100827) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 11792869 Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):984-989. "Fitz-Gibbon ST, Ladner H, Kim UJ, Stetter KO, Simon MI, Miller JH." Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum. DRAMP02535 MKLLVVYDVSDDSKRNKLANNLKKLGLERIQRSAFEGDIDSQRVKDLVRVVKLIVDTNTDIVHIIPLGIRDWERRIVIGREGLEEWLV 88 CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin) Q97Y85 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas22 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 /P2) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure Not found 3EXC resolved by X-ray. "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 11427726##18482976##PubMed ID is not availbale Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7835-7840.##J Biol Chem. 2008 Jul 18;283(29):20361-71.##To be Published "She Q, Singh RK, Confalonieri F, Zivanovic Y, Allard G, Awayez MJ, Chan-Weiher CC, Clausen IG, Curtis BA, De Moors A, Erauso G, Fletcher C, Gordon PM, Heikamp-de Jong I, Jeffries AC, Kozera CJ, Medina N, Peng X, Thi-Ngoc HP, Redder P, Schenk ME, Theriault C, Tolstrup N, Charlebois RL, Doolittle WF, Duguet M, Gaasterland T, Garrett RA, Ragan MA, Sensen CW, Van der Oost J.##Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kud" The complete genome of the crenarchaeon Sulfolobus solfataricus P2.##A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.##Structure of the RNA'se SSO8090 from Sulfolobus solfataricus. DRAMP02536 MDFWLVCYDVRDDKRRRKLAKLLEQRCQRVQYSVFECPLPEKVLTDLLHRRWLKELNLKEDSLRAYPLQRQSRSQAKIFGSPDLYEPPDFLIL 93 CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin) Q6ZEC6 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-2 Synechocystis sp. (strain PCC 6803 / Kazusa) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 14686584 DNA Res. 2003 Oct 31;10(5):221-228. "Kaneko T, Nakamura Y, Sasamoto S, Watanabe A, Kohara M, Matsumoto M, Shimpo S, Yamada M, Tabata S." "Structural analysis of four large plasmids harboring in a unicellular cyanobacterium, Synechocystis sp. PCC 6803." DRAMP02537 MGKRLYAVAYDIPDDTRRVKLANLLKSYGERVQLSVFECYLDERLLEDLRRRARRLLDLGQDALRIYPVAGQVEVLGVGPLPELREVQVL 90 CRISPR-associated endonuclease Cas2 2 (Antiviral defensin) Q746F4 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2b Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure Not found 1ZPW resolved by X-ray. "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 15064768##22942283##PubMed ID is not availbale Nat Biotechnol. 2004 May;22(5):547-553.##J Biol Chem. 2012 Oct 19;287(43):35943-52.##To be Published "Henne A, Brggemann H, Raasch C, Wiezer A, Hartsch T, Liesegang H, Johann A, Lienard T, Gohl O, Martinez-Arias R, Jacobi C, Starkuviene V, Schlenczeck S, Dencker S, Huber R, Klenk HP, Kramer W, Merkl R, Gottschalk G, Fritz HJ.##Nam KH, Ding F, Haitjema C, Huang Q, DeLisa MP, Ke A.##Ihsanawati, Murayama K, Shirouzu M, Yokoyama S." The genome sequence of the extreme thermophile Thermus thermophilus.##Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein.##Crystal structure of a hypothetical protein TT1823 from Thermus thermophilus. DRAMP02538 MRLPYLVCYDISDEGRLNRVYRFMKGKGFHIQYSVFYCILTDVELKEMKAEILKLIHSRYDDVRIYPLPNNSLVAVLGVGDRIPDGVEVFY 91 CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin) B5YJS4 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-2 Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 /YP87) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases "Dodson R.J, Durkin A.S, Wu M, Eisen J, Sutton G." The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87. DRAMP02539 MKMFTVISYDIVDDQRRTSVMKVLKGYGVRVQYSVFEAILDAREFHDLSNQLRKIIDPGQDSIRCYRLDQVAAQRTVIYGIGLTTTDPTHYMV 93 CRISPR-associated endoribonuclease Cas2 3 (Antiviral defensin) A9WJV5 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-3 Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases "Copeland A, Lucas S, Lapidus, Barry K, Glavina del Rio T, Hammon N, Israni S, Dalin E, Tice H, Pitluck S, Chertkov O, Brettin T, Bruce D, Detter JC, Han C, Schmutz J, Larimer F, Land M, Hauser L, Kyrpides N, Mikhailova N, Pierson BK, Blankenship RE, Richardson P." Complete sequence of Chloroflexus aurantiacus J-10-fl. DRAMP02540 MLIIVTYDVSTETRAGRKRLRRVAKLCESIGQRVQKSVFECRINLMQYEELERRLLSEIDEQEDNLRLYRLTEPAELHVKEYGNFKAIDFEGPLTI 96 CRISPR-associated endoribonuclease Cas2 3 (Antiviral defensin) Q82W51 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas23 Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 12700255##18482976 J Bacteriol. 2003 May;185(9):2759-2773.##J Biol Chem. 2008 Jul 18;283(29):20361-71. "Chain P, Lamerdin J, Larimer F, Regala W, Lao V, Land M, Hauser L, Hooper A, Klotz M, Norton J, Sayavedra-Soto L, Arciero D, Hommes N, Whittaker M, Arp D.##Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF." Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea.##A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. DRAMP02541 MILVTYDVNTVEPGGRRRLRQVAKACQDYGQRVQNSVFEVEVDPARWVALKARLEAIIDPALDSLRYYDLGANWQRRVDHVGAKPAVDLHGPLIL 95 CRISPR-associated endoribonuclease Cas2 3 (Antiviral defensin) Q2RW60 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-3 Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (DEC-2005) to the EMBL/GenBank/DDBJ database "Copeland A, Lucas S, Lapidus A, Barry K, Detter JC, Glavina T, Hammon N, Israni S, Pitluck S, Munk AC, Brettin T, Bruce D, Han C, Tapia R, Gilna P, Schmutz J, Larimer F, Land M, Kyrpides N, Mavrommatis K, Richardson P, Zhang Y, Roberts G, Reslewic S, Zhou S, Schwartz DC." Complete sequence of the chromosome of Rhodospirillum rubrum ATCC 11170. DRAMP02542 MFLYVIAYDIPDDRRRKKMADLLEGYGQRVQYSVFECTLSKSKFNELQKRLRKIYQSEEDSLRFYPLSGHTLTQVDIWGEPPLTKPPGSVIV 92 CRISPR-associated endoribonuclease Cas2 3 (Antiviral defensin) Q6ZEA5 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-3 Synechocystis sp. (strain PCC 6803 / Kazusa) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 14686584 DNA Res. 2003 Oct 31;10(5):221-228. "Kaneko T, Nakamura Y, Sasamoto S, Watanabe A, Kohara M, Matsumoto M, Shimpo S, Yamada M, Tabata S." "Structural analysis of four large plasmids harboring in a unicellular cyanobacterium, Synechocystis sp. PCC 6803." DRAMP02543 MPYLIVTYDIAEERVNKVRKILKKYFMWVQNSVFEGEITEGKLLKCKLELEKVIDKEVDSVYFYSLENRLNYRKTVLGIEKEITGNIL 88 CRISPR-associated endoribonuclease Cas2 3 (Antiviral defensin) B5YIU7 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-3 Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 /YP87) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases "Dodson R.J, Durkin A.S, Wu M, Eisen J, Sutton G." The complete genome sequence of Thermodesulfovibrio yellowstonii strain ATCC 51303 / DSM 11347 / YP87. DRAMP02544 MVYVLIAYDISNDSKRLKAAQKLLQMGFARVQKSVYIAKGGRSLAKEAYRALQRLADSGKDKIMVMVIPGDSVRDAYGLGGSLEDGKRVVVV 92 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q05E21 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC100138 / K1) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 10382966 "DNA Res. 1999 Apr 30;6(2):83-101, 145-152." "Kawarabayasi Y, Hino Y, Horikawa H, Yamazaki S, Haikawa Y, Jin-no K, Takahashi M, Sekine M, Baba S, Ankai A, Kosugi H, Hosoyama A, Fukui S, Nagai Y, Nishijima K, Nakazawa H, Takamiya M, Masuda S, Funahashi T, Tanaka T, Kudoh Y, Yamazaki J, Kushida N, Oguchi A, Kikuchi H, et al." "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." DRAMP02545 MSSRLAVFAYDIRDDRVRRHALKTLREWRLDGQLSVHECQVDAIQARRLFEQLGDELDPATDAWLFTWVEGHRAVLARGKGRTTALQDGLLLAA 94 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) D3RW30 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D)(Chromatium vinosum) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases "Lucas S, Copeland A, Lapidus A, Cheng J-F, Bruce D, Goodwin L, Pitluck S, Munk AC, Detter JC, Han C, Tapia R, Larimer F, Land M, Hauser L, Kyrpides N, Ivanova N, Zigann R, Dahl C, Woyke T." Complete sequence of plasmid 1 of Allochromatium vinosum DSM 180. DRAMP02546 MLVLITYDVQTSSMGGTKRLRKVAKACQNYGQRVQNSVFECIVDSTQLTSLKLELTSLIDEEKDSLRIYRLGNNYKTKVEHIGAKPSIDLEDPLIF 96 CRISPR-associated endonuclease Cas2 (Antiviral defensin) Q9KFX8 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM9153 / C-125) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure Not found "4ES1, 4ES2, 4ES3 resolved by X-ray." "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 11058132##22942283##PubMed ID is not availbale Nucleic Acids Res. 2000 Nov 1;28(21):4317-4331.##J Biol Chem. 2012 Oct 19;287(43):35943-52.##To be Published "Takami H, Nakasone K, Takaki Y, Maeno G, Sasaki R, Masui N, Fuji F, Hirama C, Nakamura Y, Ogasawara N, Kuhara S, Horikoshi K.##Nam KH, Ding F, Haitjema C, Huang Q, DeLisa MP, Ke A.##Ke A, Nam KH." Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis.##Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein.##Crystal structure of BH0342 protein. DRAMP02547 MLVLVTYDVNTETPAGRRRLRRIAKTCQNYGQRVQFSVFECNVDPAQWVKLRSKLLNEMDPKLDSLRFYFLGSNWQGRVEHEGAKEPRDLEGTLIL 96 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q8KDC5 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 12093901 Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9509-9514. "Eisen JA, Nelson KE, Paulsen IT, Heidelberg JF, Wu M, Dodson RJ, Deboy R, Gwinn ML, Nelson WC, Haft DH, Hickey EK, Peterson JD, Durkin AS, Kolonay JL, Yang F, Holt I, Umayam LA, Mason T, Brenner M, Shea TP, Parksey D, Nierman WC, Feldblyum TV, Hansen CL, Craven MB, Radune D, Vamathevan J, Khouri H, White O, Gruber TM, Ketchum KA, Venter JC, Tettelin H, Bryant DA, Fraser CM." "The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." DRAMP02548 MYVIMVYDVNQRRINKVLNTARKYLEWIQNSVLEGEITEAKFEMLKREIEIIINEEEDSVIFYIMRTTKYSERQILGIEKNKREQIL 87 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) B8DZH3 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Dictyoglomus turgidum (strain Z-1310 / DSM 6724) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases "Lucas S, Copeland A, Lapidus A, Glavina del Rio T, Tice H, Bruce D, Goodwin L, Pitluck S, Sims D, Brettin T, Detter J.C, Han C, Larimer F, Land M, Hauser L, Kyrpides N, Mikhailova N, Mead D." Complete sequence of Dictyoglomus turgidum DSM 6724. DRAMP02549 MSMLVVVTENVPPRLRGRLAIWLLEVRAGVYVGDVSAKIREMIWEQIAGLAEEGNVVMAWATNTETGFEFQTFGLNRRTPVDLDGLRLVSFLPV 94 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) "P45956, Q2MA75" Belongs to the CRISPR-associated endoribonuclease Cas2 prote ygbF Escherichia coli (strain K12) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). Induction: Repressed by H-NS, activated by LeuO. Activated by the BaeSR two-component regulatory system, possibly due to envelope stress. Part of the casABCDE-ygbT-ygbF operon." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 2656660##9278503##16738553 J Bacteriol. 1989 Jun;171(6):3553-6.##Science. 1997 Sep 5;277(5331):1453-1462.##Mol Syst Biol. 2006;2:2006.0007. "Nakata A, Amemura M, Makino K.##Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y.##Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T." Unusual nucleotide arrangement with repeated sequences in the Escherichia coli K-12 chromosome.##The complete genome sequence of Escherichia coli K-12.##Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. DRAMP02550 MFVVLVYDTAAERNPNALRTCRKYLHWVQRSVFEGELSAAQYRALMTTLRDQLDLTYDSIRVYRTRSPALVETEWLGVPLGNQDSVL 87 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q0RE94 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Frankia alni (strain ACN14a) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 17151343 Genome Res. 2007 Jan;17(1):7-15. "Normand P, Lapierre P, Tisa LS, Gogarten JP, Alloisio N, Bagnarol E, Bassi CA, Berry AM, Bickhart DM, Choisne N, Couloux A, Cournoyer B, Cruveiller S, Daubin V, Demange N, Francino MP, Goltsman E, Huang Y, Kopp OR, Labarre L, Lapidus A, Lavire C, Marechal J, Martinez M, Mastronunzio JE, Mullin BC, Niemann J, Pujic P, Rawnsley T, Rouy Z, Schenowitz C, Sellstedt A, Tavares F, Tomkins JP, Vallenet D, Valverde C, Wall LG, Wang Y, Medigue C, B" Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography. DRAMP02551 MEHLYIVSYDIRNQRRWRRLFKTMHGFGCWLQLSVFQCRLDRIRIIKMEAAINEIVNHAEDHVLILDLGPAENVKPKVSSIGKTFDPILRQAVIV 95 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q74H35 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 14671304 Science. 2003 Dec 12;302(5652):1967-1969. "Meth BA, Nelson KE, Eisen JA, Paulsen IT, Nelson W, Heidelberg JF, Wu D, Wu M, Ward N, Beanan MJ, Dodson RJ, Madupu R, Brinkac LM, Daugherty SC, DeBoy RT, Durkin AS, Gwinn M, Kolonay JF, Sullivan SA, Haft DH, Selengut J, Davidsen TM, Zafar N, White O, Tran B, Romero C, Forberger HA, Weidman J, Khouri H, Feldblyum TV, Utterback TR, Van Aken SE, Lovley DR, Fraser CM." Genome of Geobacter sulfurreducens: metal reduction in subsurface environments. DRAMP02552 MPYVVVFYDVSDNKRRDLLAKTLQSLGLVRVQRSVFMGRGGYTKAKEAIRAASRIVDARTDSVVALVVPEDYARRMLVYGGIMSDPKQKQAVRVV 95 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) A2BKJ6 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Hyperthermus butylicus (strain DSM 5456 / JCM 9403) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 17350933 Archaea. 2007 May;2(2):127-135. "Brgger K, Chen L, Stark M, Zibat A, Redder P, Ruepp A, Awayez M, She Q, Garrett RA, Klenk HP." "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C." DRAMP02553 MRGGNLKVLVVYDITDDSLRLKVAEILKDLGLFRIQKSAFIGEMTSQERENMEEILRRQNLGPSDRIDVFPICDRDLKMHSQIGRGKFGRGPP 93 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) B1L402 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Korarchaeum cryptofilum (strain OPF8) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 18535141 Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8102-8107. "Elkins JG, Podar M, Graham DE, Makarova KS, Wolf Y, Randau L, Hedlund BP, Brochier-Armanet C, Kunin V, Anderson I, Lapidus A, Goltsman E, Barry K, Koonin EV, Hugenholtz P, Kyrpides N, Wanner G, Richardson P, Keller M, Stetter KO." A korarchaeal genome reveals insights into the evolution of the Archaea. DRAMP02554 MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL 94 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q8F1F4 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai(strain 56601) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 12712204 Nature. 2003 Apr 24;422(6934):888-893. "Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, Zhang YX, Xiong H, Lu G, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ, Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, Ma W, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Saint Girons I, Somerville RL, Wen YM, Shi MH, Chen Z, Xu JG, Zhao GP." Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. DRAMP02555 MYVVIVYDVGVERVNKVRSFLREYMNWVQNSVFEGELTKAEFLKIKSRLKELIQESSDHIIFYSSRDRKYLGIEDLGTPKADTSNII 87 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q8TJV8 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /C2A) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 11932238 Genome Res. 2002 Apr;12(4):532-542. "Galagan JE, Nusbaum C, Roy A, Endrizzi MG, Macdonald P, FitzHugh W, Calvo S, Engels R, Smirnov S, Atnoor D, Brown A, Allen N, Naylor J, Stange-Thomann N, DeArellano K, Johnson R, Linton L, McEwan P, McKernan K, Talamas J, Tirrell A, Ye W, Zimmer A, Barber RD, Cann I, Graham DE, et al." The genome of M. acetivorans reveals extensive metabolic and physiological diversity. DRAMP02556 MAVFLIAYDLVNERRGTHDYQPLWDELKRLGAHRTQFSLWLVSANNTTAEVRQHFQQFVDSNDRIWVTRLRKSQYDYANAIGGTNNWLSNNPPEA 95 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) B7KNJ8 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Methylobacterium extorquens (strain CM4 / NCIMB 13688)(Methylobacterium chloromethanicum) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding PubMed ID is not availbale Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases "Lucas S, Copeland A, Lapidus A, Glavina del Rio T, Dalin E, Tice H, Bruce D, Goodwin L, Pitluck S, Chertkov O, Brettin T, Detter J.C, Han C, Larimer F, Land M, Hauser L, Kyrpides N, Mikhailova N, Marx C, Richardson P." Complete sequence of chromosome of Methylobacterium chloromethanicum CM4. DRAMP02558 MKVLVSFEIKFKTNKEKIISILKHFGFRRMQENLYFGDVEYDELYAMQSDIMENIREYDSILTIPICKSCYLKLNVFGRNLSFKDELYKIF 91 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) D3E4V5 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM13430 / M1) (Methanobacterium rumi "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 20126622 PLoS One. 2010 Jan 28;5(1):e8926. "Leahy SC, Kelly WJ, Altermann E, Ronimus RS, Yeoman CJ, Pacheco DM, Li D, Kong Z, McTavish S, Sang C, Lambie SC, Janssen PH, Dey D, Attwood GT." The genome sequence of the rumen methanogen Methanobrevibacter ruminantium reveals new possibilities for controlling ruminant methane emissions. DRAMP02559 MVVTVYLLIVYDVGVERVNRVKSYLRTELHWVQNSVFEGEVTESQFRRIETNLERIIDRERDSVIIYSFRSERAMNRNVLGLEKSPLDVIL 91 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) O27155 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 /JCM 10044 / NBRC 100330 / Delt "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 9371463##18482976 J Bacteriol. 1997 Nov;179(22):7135-7155.##J Biol Chem. 2008 Jul 18;283(29):20361-71. "Smith DR, Doucette-Stamm LA, Deloughery C, Lee H, Dubois J, Aldredge T, Bashirzadeh R, Blakely D, Cook R, Gilbert K, Harrison D, Hoang L, Keagle P, Lumm W, Pothier B, Qiu D, Spadafora R, Vicaire R, Wang Y, Wierzbowski J, Gibson R, Jiwani N, Caruso A, Bush D, Reeve JN, et al.##Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF" Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics.##A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. DRAMP02560 MAEPRRWYLITYDIRDPKRWRKVHALLKGYGEWLQLSVFRCSLTDRDREKLRWELSRRMDAVDTLLVIGLCGGCVERVRAINAKEDWPEEPAPFKVL 97 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q1CW51 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Myxococcus xanthus (strain DK 1622) "Antimicrobial, Antiviral" Transcript level Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). Induction: Part of an operon going from at least MXAN_7266 to MXAN_7259 that includes a CRISPR operon with transcription continuing into the pre-crRNA locus." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 17015832##17369305 Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15200-5.##J Bacteriol. 2007 May;189(10):3738-3750. "Goldman BS, Nierman WC, Kaiser D, Slater SC, Durkin AS, Eisen JA, Ronning CM, Barbazuk WB, Blanchard M, Field C, Halling C, Hinkle G, Iartchuk O, Kim HS, Mackenzie C, Madupu R, Miller N, Shvartsbeyn A, Sullivan SA, Vaudin M, Wiegand R, Kaplan HB.##Viswanathan P, Murphy K, Julien B, Garza AG, Kroos L." "Evolution of sensory complexity recorded in a myxobacterial genome.##Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats." DRAMP02561 MQYKINMYAIVVYDVNVSRQNQIREFLRKYLYHVQRSVFEGEISPSSLYYMKKILQSYIGETDSLIIYVLRDKSCLMDKIVLGEDKDLQIY 91 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q74N46 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Nanoarchaeum equitans (strain Kin4-M) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 14566062 Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12984-8. "Waters E, Hohn MJ, Ahel I, Graham DE, Adams MD, Barnstead M, Beeson KY, Bibbs L, Bolanos R, Keller M, Kretz K, Lin X, Mathur E, Ni J, Podar M, Richardson T, Sutton GG, Simon M, Soll D, Stetter KO, Short JM, Noordewier M." The genome of Nanoarchaeum equitans: insights into early archaeal evolution and derived parasitism. DRAMP02562 MYIVVVYDVGVERVNKVKKFLRMHLNWVQNSVFEGEVTLAEFERIKEGLKKIIDENSDSVIIYKLRSMPPRETLGIEKNPIEEII 85 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q8U1T8 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) "Antimicrobial, Antiviral" Protein level Combine helix and strand structure Not found 2I0X resolved by X-ray. "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 10430560##PubMed ID is not availbale Genetics. 1999 Aug;152(4):1299-1305.##Submitted (AUG-2006) to the PDB data bank. "Maeder DL, Weiss RB, Dunn DM, Cherry JL, Gonzlez JM, DiRuggiero J, Robb FT.##Chen LQ, Fu ZQ, Hwang J, Chang J, Chen L, Wang Y, Zhang H, Liu ZJ, Rose JP, WangBC." Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences.##Crystal Structure of Hypothetical Protein Pf1117 from Pyrococcus furiosus. DRAMP02563 MYIIVVYDVSVERVNRVKKFLRQHLHWVQNSVFEGEVTLAEFERIKAGIGELIDGDEDSVVIYKLRSMPKREVMGVEKNPIEDII 85 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q5JD44 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1)(Thermococcus kodakaraensis (strain "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 15710748 Genome Res. 2005 Mar;15(3):352-363. "Fukui T, Atomi H, Kanai T, Matsumi R, Fujiwara S, Imanaka T." Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes. DRAMP02564 MYVIMVYDVNEKRVAKILKIARKYLKWVQNSVLEGELSPGKYEKLKLEVSRLIDEKEDSVRFYVMDSQKVFNLETLGVEKGEDGFIF 87 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) Q9X2B6 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 10360571 Nature. 1999 May 27;399(6734):323-329. "Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM." Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. DRAMP02565 MIVIVAYDISDEDRRGRLRRYLRRLGLARVNRSVYAGPGTATTAELVAERAKEIVEEGDSVFVIVVREDEYQRAHVFDGRDYYIVSERKYEVY 93 CRISPR-associated endoribonuclease Cas2 (Antiviral defensin) A1RZT9 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2 Thermofilum pendens (strain Hrk 5) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 18263724 J Bacteriol. 2008 Apr;190(8):2957-2965. "Anderson I, Rodriguez J, Susanti D, Porat I, Reich C, Ulrich LE, Elkins JG, Mavromatis K, Lykidis A, Kim E, Thompson LS, Nolan M, Land M, Copeland A, Lapidus A, Lucas S, Detter C, Zhulin IB, Olsen GJ, Whitman W, Mukhopadhyay B, Bristow J, Kyrpides N." Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction. DRAMP02567 MYILITYDVSTETEAGKKRLRKVAQVCKDFGQRVQKSVFECSVNEAQFEQLKHRLLQCIDEKSDSLRIYRLREPAKKYIQEYGVNLTIDFDAPLVL 96 CRISPR-associated endoribonuclease Cas2 1 (Antiviral defensin) Q2RL67 Belongs to the CRISPR-associated endoribonuclease Cas2 prote cas2-1 Moorella thermoacetica (strain ATCC 39073) "Antimicrobial, Antiviral" Homology Not found Not found None "Function: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity). " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Metal-binding 18631365 Environ Microbiol. 2008 Oct;10(10):2550-2573. "Pierce E, Xie G, Barabote RD, Saunders E, Han CS, Detter JC, Richardson P, Brettin TS, Das A, Ljungdahl LG, Ragsdale SW." The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum). DRAMP02642 GFCRCLCRRGVCRCICTR 18 "Rhesus theta-defensin 1 (RTD-1; primates, mammals, animals)" "P82271, P82270, Q9TU01" Belongs to the alpha-defensin family (Theta subfamily) Not found Macaca mulatta (Rhesus macaque) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Beta strand (4 strands; 10 residues) Not found 1HVZ resolved by NMR. "Function: RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S. aureus 502A and L. monocytogenes, the Gram-negative bacterium S. typhimurium, and the fungi C. albicans 16820 and C. neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E. coli ML35. Subunit structure: RTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked. Tissue specificity: RTD-1 is expressed in bone marrow. Detected in promyelocytes, myelocytes and mature neutrophils and monocytes. Developmental stage: RTD-1 expression begins early during granulocyte myelopoiesis. PTM: Forms a cyclic peptide with 1 subunit B (RTD-2) or with 1 subunit A (RTD-1). An additional intersubunit disulfide bond is formed. Miscellaneous: RTD-1 is 10-fold more present in cells than RTD-2." "Gram-positive bacteria: Staphylococcus aureus 502a and Listeria monocytogenes;##Gram-negative bacteria: Salmonella typhimurium, Escherichia coli ML35.##Fungi: Candida albicans 16820, Cryptococcus neoformans 271A (the activity of RTD-2 against Escherichia coli ML35 was 2-3-fold less than those of RTD-1 and RTD-3)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12." L No cytotoxicity information found Not found 10521339##1152799##11675394 Science. 1999 Oct 15;286(5439):498-502.##J Leukoc Biol. 2001 Sep;70(3):461-464.##J Biol Chem. 2002 Feb 1;277(5):3079-3084. "Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME.##Leonova L, Kokryakov VN, Aleshina G, Hong T, Nguyen T, Zhao C, Waring AJ, Lehrer RI.##Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME." "A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.##Circular minidefensins and posttranslational generation of molecular diversity.##Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides." DRAMP02644 RCICTRGFCRCICTRGFC 18 "Rhesus theta-defensin 3 (RTD-3; primates, mammals, animals)" "P82270, Q9TU01" Belongs to the alpha-defensin family (Theta subfamily) Not found Macaca mulatta (Rhesus macaque) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Bridge Not found None "Function: RTD-1 and RTD-3 have similar antimicrobial activities against the Gram-positive bacteria, the Gram-negative bacteria and the fungi C. albicans 16820 and C. neoformans 271A. Subunit structure RTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked. RTD-3 is a cyclic homodimer composed of two subunits A; disulfide-linked. PTM: Forms a cyclic peptide with subunit A (RTD-3) or with subunit B (RTD-1). An additional intersubunit disulfide bond is formed. Miscellaneous: RTD-1 is 10-fold more present in cells than RTD-3." "Gram-positive bacteria: Staphylococcus aureus 502a, Listeria monocytogenes;##Gram-negative bacteria: Salmonella typhimurium, Escherichia coli ML35.##Fungi: Candida albicans 16820, Cryptococcus neoformans 271A (the activity of RTD-2 against Escherichia coli ML35 was 2-3-fold less than those of RTD-1 and RTD-3)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10521339##1152799##11675394 Science. 1999 Oct 15;286(5439):498-502.##J Leukoc Biol. 2001 Sep;70(3):461-464.##J Biol Chem. 2002 Feb 1;277(5):3079-3084. "Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME.##Leonova L, Kokryakov VN, Aleshina G, Hong T, Nguyen T, Zhao C, Waring AJ, Lehrer RI.##Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME." "A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.##Circular minidefensins and posttranslational generation of molecular diversity.##Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides." DRAMP02669 ACYCRIPACLAGERRYGTCIYQGRLWAFCC 30 "Neutrophil defensin 1 (Defensin, alpha 1; primates, mammals, animals)" Q5G863 Belongs to the alpha-defensin family DEFA1 Pan troglodytes (chimpanzee) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Homology Bridge Not found None MOA: Defensins are thought to kill microbes by permeabilizing their plasma membrane. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15494476 Physiol Genomics. 2004 Dec 15;20(1):1-11. Epub 2004 Oct 19. "Patil A, Hughes AL, Zhang G." Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes. DRAMP02739 EKKCPGRCTLKCGKHERPTLPYNCGKYICCVPVKVK 36 "TEWP (turtle egg-white protein; Reptiles, animals)" No entry found Not found Not found Caretta caretta (Loggerhead turtle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Not found Beta strand (2 strands; 2 residues) The protein has no -helix and consists of two antiparallel -sheets. 2B5B resolved by NMR. "Function: The protein showes strong antibacterial activity against Escherichia coli and Salmonella typhimurium. The protein also showes significant antiviral activity against an enveloped rhabdovirus, Chandipura virus," "Gram-negative bacteria: Escherichia coli (IC50=2.3 ?M), Salmonella typhimurium (IC50=2.8 ?M);##Gram-positive bacterium: Staphylococcus aureus (IC50=5.1 ?M).##Virus: enveloped rhabdovirus, Chandipura virus, Vesicular stomatitis virus." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16700051 Proteins. 2006 Aug 1;64(2):524-531. "Chattopadhyay S, Sinha NK, Banerjee S, Roy D, Chattopadhyay D, Roy S." Small cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity. DRAMP02742 QKKCPGRCTLKCGKHERPTLPYNCGKYICCVPVKVK 36 "Defensin-like turtle egg white protein TEWP (TEWP; Reptiles, animals)" P0CAP0 Belongs to the beta-defensin family Not found Caretta caretta (Loggerhead sea turtle) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Beta strand (2 strands; 2 residues) Three-dimensional structure of TEWP was determined by distance geometry and simulated annealing. The protein has no -helix and consists of two antiparallel -sheets. The secondary structure is consistent with the previously obtained circular dichroism spectra. 2B5B resolved by NMR. "Function: The protein showes strong antibacterial activity against Escherichia coli and Salmonella typhimurium and also showes significant antiviral activity against an enveloped rhabdovirus, Chandipura virus, which is an emerging human pathogen. Tissue specificity: Detected in egg white (at protein level)." "Gram-negative bacteria: Escherichia coli (IC50=3.3 ?M), Salmonella typhimurium (IC50=2.8 ?M);##Gram-positive bacterium: Staphylococcus aureus (IC50=5. 1?M)." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16700051 Proteins. 2006 Aug 1;64(2):524-531. "Chattopadhyay S, Sinha NK, Banerjee S, Roy D, Chattopadhyay D, Roy S." Small cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity. DRAMP02761 LLKELWTKIKGAGKAVLGKIKGLL 24 "Ponericin-L2 (ants, insects, animals)" P82422 Not found Not found Pachycondyla goeldii (Ponerine ant) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral" Protein level Alpha helix Not found None "Function: Broad spectrum of activity against both Gram-positive and Gram-negative bacteria. Tissue specificity: Expressed by the venom gland." "[Ref.11279030]Gram-positive bacteria: Bacillus cereus CIP 6624a(Inhibition zone = 6.5mm), B. megaterium ATCC 9885b(Inhibition zone = 14mm), B. stearothermophilus CIP 675(Inhibition zone = 21mm), B. subtilis ATCC 6623(Inhibition zone = 13.5mm), Enterococcus faecalis CIP 636(Inhibition zone = 4mm), Lactococcus lactis ssp. cremoris I116(Inhibition zone = 15.5mm), Streptococcus pyogenes CIP 561(Inhibition zone = 12.5mm), S. sanguinis CIP 55128(Inhibition zone = 6mm), Listeria ivanovii LMA 94d(Inhibition zone = 9.5mm), Listeria monocytogenes ATCC 15313(Inhibition zone = 9.5mm), Micrococcus luteus CIP 5345(Inhibition zone = 10.5mm), Staphylococcus aureus CIP 677(Inhibition zone = 4.5mm), Staphylococcus aureus LMA(Inhibition zone = 11mm), S. epidermidis CIP 53134(Inhibition zone = 11.5mm);##Gram-negative bacteria: Escherichia coli(Inhibition zone = 4mm), Enterobacter cloacae CIP 6085(Inhibition zone = 5mm), Klebsiella pneumoniae CIP 8291(Inhibition zone = 3.5mm), Proteus mirabilis LMA TP(Inhibition zone = 9mm), Salmonella enterica CIP 813(Inhibition zone = 1.5mm), Serratia marcescens LMA TP(Inhibition zone = 9mm), Flavobacterium meningosepticum CIP 6057(Inhibition zone = 7mm), Pseudomonas aeruginosa CIP A22(Inhibition zone = 14mm)." [Ref.11279030]Not found Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 11279030 J. Biol. Chem. 2001; 276: 17823-17829. "Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J." "Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii." DRAMP02805 SCASRCKGHCRARRCGYYVSVLYRGRCYCKCLRC 34 "Mytilin-B (molluscas, animals)" P81613 Not found Not found Mytilus edulis (Blue mussel) "Antimicrobial, Antibacterial, Antiviral" Protein level Combine helix and strand structure Not found 2EEM resolved by NMR. Function: Has antibacterial and antiviral activity. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8702979##17628674 J Biol Chem. 1996 Sep 6;271(36):21808-21813.##Dev Comp Immunol. 2008;32(3):227-238. "Charlet M, Chernysh S, Philippe H, Hetru C, Hoffmann JA, Bulet P.##Roch P, Yang Y, Toubiana M, Aumelas A." "Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis.##NMR structure of mussel mytilin, and antiviral-antibacterial activities of derived synthetic peptides." DRAMP02810 QEAQSVACTSYYCSKFCGSAGCSLYGCYLLHPGKICYCLHCSR 43 Myticin C No entry found Not found Not found Mytilus galloprovincialis (Mediterranean mussel) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17628673 Dev Comp Immunol. 2008;32(3):213-226. "Pallavicini A, Costa Mdel M, Gestal C, Dreos R, Figueras A, Venier P, Novoa B." High sequence variability of myticin transcripts in hemocytes of immune-stimulated mussels suggests ancient host-pathogen interactions. DRAMP02824 VRNSQSCRRNKGICVPIRCPGSMRQIGTCLGAQVKCCRRK 40 "Lingual antimicrobial peptide (mammals, animals)" A3RJ36 Belongs to the beta-defensin family Not found Bubalus bubalis (Domestic water buffalo) "Antimicrobial, Antibacterial, Antiviral" Protein level Bridge Not found None "Function: Has bactericidal activity (By similarity). PTM: Contains three disulfide bonds 7-36; 14-29; 19-37." "Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, Candida albicans, Rinderpest Virus (RPV) and Newcastle Disease Virus (NDV)" No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18826332 Altern Lab Anim. 2008 Sep;36(4):429-440. "Das H, Swamy N, Sahoo G, Ahmed S.U, More T." Beta-defensin antibiotic peptides in the innate immunity of the buffalo: in vivo and in vitro studies. DRAMP02833 SALYALYDFSPPARKMRAYTVRAYVHGSYSRRGPWYDFEPVPGASMDGL 49 "Glycolactin (Antiviral defensin; mammals, animals)" P59760 Belongs to the pancreatic ribonuclease family Not found Bos taurus (Bovine) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: MManifests poly C-specific RNase activity toward yeast tRNA, elicits a dose-dependent inhibition of cell-free translation, inhibits formation of superoxide ions in vitro and inhibits the hemagglutinating activities of soybean lectin and Ricinus communis agglutinin 120. Inhibits HIV-1 reverse transcriptase. Tissue specificity: Milk." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10486275##11105990 Biochem Biophys Res Commun. 1999 Sep 16;263(1):187-191.##Life Sci. 2000 Oct 20;67(22):2745-2752. "Ye XY, Cheng KJ, Ng TB.##Wang H, Ye X, Ng TB." Isolation and characterization of angiogenin-1 and a novel protein designated lactogenin from bovine milk.##First demonstration of an inhibitory activity of milk proteins against human immunodeficiency virus-1 reverse transcriptase and the effect of succinylation. DRAMP02985 RRCICTTRTCRFPYRRLGTCLFQNRVYTFCC 31 "Neutrophil cationic peptide 2 (CP-2; GNCP-2; pigs, mammals, animals)" "P49112, Q9R0Z5" Belongs to the alpha-defensin family Not found Cavia porcellus (Guinea pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Homology Bridge Not found None "Function: Has antibiotic, anti-fungi and antiviral activity. PTM: Contains three disulfide bonds (By similarity)." Gram-negative bacterium: Escherichia coli;##Gram-positive bacterium: Staphylococcus aureus. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 8173076##10738945 DNA Seq. 1993;4(2):123-128.##Inflamm Res. 2000 Feb;49(2):73-79. "Nagaoka I, Nonoguchi A, Yamashita T.##Nagaoka I, Hirota S, Yomogida S, Ohwada A, Hirata M." Cloning and characterization of the guinea pig neutrophil cationic peptide-1 and -2 genes.##Synergistic actions of antibacterial neutrophil defensins and cathelicidins. DRAMP02986 RRCICTTRTCRFPYRRLGTCIFQNRVYTFCC 31 "Neutrophil cationic peptide 1 (GPNP; Antiviral defensin; pigs, mammals, animals)" "Q64365, P11478" Belongs to the alpha-defensin family Not found Cavia porcellus (Guinea pig) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Bridge Not found None "Function: Has antibiotic, anti-fungi and antiviral activity. Tissue specificity: Bone marrow." "Gram-positive bacteria: Staphylococcus aureus, Streptococcus;##Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa.##Yeast: Candida albicans." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2473036##3623703 Infect Immun. 1989 Aug;57(8):2405-2409.##Infect Immun. 1987 Sep;55(9):2281-2286. "Yamashita T, Saito K.##Selsted ME, Harwig SS." "Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides.##Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin." DRAMP02992 GLPRKILCAIAKKKGKCKGPLKLVCKC 27 "Lasiocepsin (Insects, animals)" No entry found Not found Not found Lasioglossum laticeps (Eusocial Bee) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Not found Not found None "Function: The synthetic lasiocepsin possessed antimicrobial activity against both Gram-positive and -negative bacteria, antifungal activity against Candida albicans, and weak hemolytic activity against human erythrocytes." No MICs found in DRAMP database [Ref.22038181]LC50>200 M against human red blood cells Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 22038181 Amino Acids. 2012 Aug;43(2):751-761. "Monincov L, Slaninov J, Fuck V, Hovorka O, Voburka Z, Bednrov L, Malon P, Stokrov J, Cerovsk? V." "Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). " DRAMP03064 HGVSGHGQHGVHG 13 "Alloferon-1 (Insects, animals)" P83412 Not found Not found Calliphora vicina (Blue blowfly) (Calliphora erythrocephala) "Antimicrobial, Antiparasitic, Antiviral, Antitumor" Protein level Not found Not found None "Function: Antimicrobial peptide presumably with antiparasitic, antiviral and/or Antitumoral activities. Tissue specificity: Hemolymph. Induction: By bacterial infection. Miscellaneous: Stimulates antiviral and antitumoral resistance when injected in mice. Enhances natural cytotoxicity of blood and spleen lymphocytes. Induces interferon production in mouse and human." Human influenza viruses A and B. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12235362 Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32. "Chernysh S, Kim SI, Bekker G, Pleskach VA, Filatova NA, Anikin VB, Platonov VG, Bulet P." Antiviral and antitumor peptides from insects. DRAMP03065 GVSGHGQHGVHG 12 "Alloferon-2 (Insects, animals)" No entry found Not found Not found Calliphora vicina (Blue blowfly) (Calliphora erythrocephala) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Not found Not found None "Function: Alloferon can (i) stimulate natural cytotoxicity of human peripheral blood lymphocytes, (ii) induces IFN synthesis in mouse and human models, and (iii) enhances antiviral and antitumor resistance in mice. " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12235362 Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32. "Chernysh S, Kim SI, Bekker G, Pleskach VA, Filatova NA, Anikin VB, Platonov VG, Bulet P." Antiviral and antitumor peptides from insects. DRAMP03087 DDMTMKPTPPPQYPLNLQGGGGGGSGDGFGFAVQGHQKVWTSDNGRHEIGLNGGYGQHLGGPYGNSEPSWKVGSTYTYRFPNF 83 "Drosophila diptericin (Insects, animals)" No entry found Not found Not found Drosophila melanogaster (Fruit fly) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 2125051 J Biol Chem. 1990 Dec 25;265(36):22493-8. "Wicker C, Reichhart JM, Hoffmann D, Hultmark D, Samakovlis C, Hoffmann JA." Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides. DRAMP18224 EKYTEAPEYI 10 Ala-6-fenycin (Bacteriocin) No entry found Belongs to the lipopeptides family Not found Bacillus sp. strain P34 "Antimicrobial, Antibacterial, Anti-Gram+, Antiviral" Not found "An acyl chain (C15 to C17 carbons) is attached to E1, residue 2 is an ornithine (represented as K), and the carboxylic group of C-terminal I10 forms an ester bond with the side chain of Y3. " None Comment: No comments found on DRAMP database Gram-positive No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 25477947 Braz J Microbiol. 2014 Oct 9;45(3):1089-94. eCollection 2014. "Scopel e Silva D, de Castro CC, da Silva e Silva F, Sant'anna V, Vargas GD, de Lima M, Fischer G, Brandelli A, da Motta Ade S, H" Antiviral activity of a Bacillus sp. P34 peptide against pathogenic viruses of domestic animals. DRAMP03235 QAFKTFTPDWNKIRNDAKRMQDNLEQMKKRFNLNL 35 "M-zodatoxin-Lt6b (M-ZDTX-Lt6b; Latarcin 6b, Ltc-6b; spiders, Arthropods, animals)" Q1ELU8 Belongs to the latarcin family Not found Lachesana tarabaevi (Spider) "Antibacterial, Antimicrobial, Antifungal, Antiviral" Transcript level Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16735513 J Biol Chem. 2006 Jul 28;281(30):20983-20992. "Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV. " "Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity." DRAMP03289 FFLLFLQGAAGNSVLCRIRGGRCHVGSCHFPERHIGRCSGFQACCIRTWG 50 "Apl-AvBD16 (Beta defensins; Ducks, birds, animals)" No entry found Not found Not found Anas platyrhynchos (Peking duck) "Antimicrobial, Antibacterial, Antiviral" Not found Bridge Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23112840 PLoS One. 2012;7(10):e47743. "Ma D, Zhang K, Zhang M, Xin S, Liu X, Han Z, Shao Y, Liu S." "Ma D, Zhang K, Zhang M, Xin S, Liu X, Han Z, Shao Y, Liu S." DRAMP18204 SNASVWECCSTGSWVPFTCC 20 Labyrinthopeptin A1(Bacteriocin) C0MP59 Belongs to the lantibiotics family (Class I bacteriocin) labA1 Actinomadura namibiensis DSM 6313 "Antimicrobial, Antiviral, Anti-HIV, Anti-HSV" Not found "LabyA1 contains a special amino acid labionin at positions 1, 4, 8, 10, 13, and 19. Labs 1,4 and labs 10, 13 are connected via a carbon-carbon bond, while labs 4, 8 and labs 13, 19 form normal thioether bonds. In addition, a disulfide bond occurs between C9 and C20." None "Function: LabyA1 also demonstrated additive to synergistic effects in its anti-HIV-1 and anti-HSV-2 activity with anti(retro)viral drugs in dual combinations such as tenofovir, acyclovir, saquinavir, raltegravir and enfuvirtide." HSV(EC50: 0.29 No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23724015 PLoS One. 2013 May 28;8(5):e64010. F The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications DRAMP18205 SDWSLWECCSTGSLFACC 18 Labyrinthopeptin A2 (Bacteriocin) C0MP60 Belongs to the lantibiotics family (Class I bacteriocin) labA2 Actinomadura namibiensis DSM 6313 "Antimicrobial, Antiviral" Not found "This peptide contains a special amino acid labionin at positions 1, 4, 8, 10, 13, and 17. Labs 1,4 and labs 10, 13 are connected via a carbon-carbon bond, while labs 4, 8 and labs 13, 17 form normal thioether bonds. In addition, a disulfide bond occurs between C9 and C18. " None Comment: No comments found on DRAMP database HSV No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20191635 Angew Chem Int Ed Engl. 2010 Mar 22;49(13):2436-40. M In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification. DRAMP03421 CSCRTSSCRFGERLSGACRLNGRIYRLCC 29 "Neutrophil antibiotic peptide NP-3 (RatNP-3a, RatNP-3b; Rodents, mammals, animals)" "Q62713, Q9Z1F1" Belongs to the alpha-defensin family Not found Rattus norvegicus (Rat) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Bridge Not found None "Active in vitro against S. aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus." "Gram-positive bacterium: Staphylococcus aureus 502A;##Gram-negative bacterium: Escherichia coli ML-35.##Fungi: Candida albicans 820, Cryptococcus neoformans A-383." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Cyclization(Cys1 and Cys29). Cyclization(Cys1 and Cys29). "Disulfide bonds between Cys1 and Cys29,Cys3 and Cys18,Cys8 and Cys28." L No cytotoxicity information found Not found 2254017##7594610 Infect. Immun. 1990;58:3899-3902.##J. Immunol. 1995;155:4476-4484. "Eisenhauer P.B, Harwig S.S.S.L, Szklarek D, Ganz T, Lehrer R.I.##Yount N.Y, Wang MS.C, Yuan J, Banaiee N, Ouellette A.J, Selsted M.E." Polymorphic expression of defensins in neutrophils from outbred rats.##Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. DRAMP03591 ACYCRIPACIAGERRYGTCIYQGRLWAFCC 30 "Neutrophil defensin 1 (Defensin, alpha 1; HNP-1, HP-1; Human, mammals, animals)" "P59665, P11479, Q14125, Q6EZF6" Belongs to the alpha-defensin family "DEFA1, DEFA1B" Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)" Protein level Beta strand "Compared to HNP-2, HNP-1 contains one additional residue (Ala) at the N-terminus. It contains a long stretch of a double-stranded antiparallel beta-sheet in a hairpin conformation that contains a beta-bulge, a short region of triple-stranded beta-sheet, and several tight turns." 2KHT resolved by NMR "Function: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. PTM: ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production. Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-rybosylation." "[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(approximately 50% inbibition at 1 g/mL (290 nM));SARS-CoV-2 variant P.1:inhibition of infection in HeLa-hACE2 cells(67% inbibition at 50 g/mL);SARS-CoV-2 variant B.1.1.7:inhibition of infection in HeLa-hACE2 cells(58% inbibition at 50 g/mL).##[Ref.15616305] Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=3.60.3 g/ml), E. coli ATCC 25922 (vLD50=3.70.4 g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=100.5 g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=4.21.0 g/ml), Staphylococcus aureus ATCC 29213 (vLD50=2.10.3 g/ml), Bacillus cereus ATCC 10876 (vLD50=0.220.03 g/ml).##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s).##[Ref.15118082]Gram-positive bacteria: Bacillus subtilis (Inhibition zone=24 mm in PH5.5, Inhibition zone=20 mm in PH7.5 completely inhibit at 10 g/well), Staphylococcus aureus (Inhibition zone=1 mm in PH5.5, Inhibition zone=7 mm incompletely inhibit and Inhibition zone=2 mm completely inhibit in PH7.5 at 10 g/well);##Gram-negative bacteria: Escherichia coli (Inhibition zone=5 mm incompletely inhibit and Inhibition zone=2 mm completely inhibit in PH7.5 at 10 g/well);##Fungi: Candida albicans (Inhibition zone=13 mm in PH5.5, Inhibition zone=10 mm in PH7.5 completely inhibit at 10 g/well)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys2 and Cys30). "Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29." L [Ref.34206990]No cytotoxicity on HEK293T cells up to 50 g/mL. Not found 34206990##19253295##15616305##15118082 Viruses. 2021 Jun 26;13(7):1246.##Proteomics. 2009 Mar;9(5):1364-1373.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.##Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-8. "Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Stegemann C, Kolobov A Jr, Leonova YF, Knappe D, Shamova O, Ovchinnikova TV, Kokryakov VN, Hoffmann R.##Ericksen B, Wu Z, Lu W, Lehrer RI.##Yount NY, Yeaman MR." "Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Isolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles.##Antibacterial activity and specificity of the six human {alpha}-defensins.##Multidimensional signatures in antimicrobial peptides." DRAMP03592 CYCRIPACIAGERRYGTCIYQGRLWAFCC 29 "Neutrophil defensin 2 (HNP-2, HP-2, HP2; Human, mammals, animals)" "P59665, P11479, Q14125, Q6EZF6, P59666, P11479, Q14125" Belongs to the alpha-defensin family DEFA1 AND DEFA1B Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)" Protein level Beta strand Not found "1ZMH, 1ZMI, 1ZMK resolved by X-ray." "Function: Defensin 2 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. PTM: Contains three disulfide bonds 1-29; 3-18; 8-28." "[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(approximately 50% inbibition at 1 g/mL (290 nM)).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=3.50.79 ?g/ml), E. coli ATCC 25922 (vLD50=3.50.6 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=164.0 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=4.20.9 ?g/ml), S. aureus ATCC 29213 (vLD50=2.40.3 ?g/ml), Bacillus cereus ATCC 10876 (vLD50=0.220.04 ?g/ml).(Ref.2)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal "Disulfide bonds between Cys1 and Cys29,Cys3 and Cys18,Cys8 and Cys28." L No cytotoxicity information found in the reference(s) presented Not found 34206990##15616305##15894545 Viruses. 2021 Jun 26;13(7):1246.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.##J Biol Chem. 2005 Sep 23;280(38):32921-9. "Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Ericksen B, Wu Z, Lu W, Lehrer RI.##Xie C, Prahl A, Ericksen B, Wu Z, Zeng P, Li X, Lu WY, Lubkowski J, Lu W." Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Antibacterial activity and specificity of the six human {alpha}-defensins.##Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids. DRAMP03593 DCYCRIPACIAGERRYGTCIYQGRLWAFCC 30 "Neutrophil defensin 3 (Defensin, alpha 3; HNP-3, HP-3, HP3; Human, mammals, animals)" "P59666, P11479, Q14125" Belongs to the alpha-defensin family DEFA3 Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)" Protein level Beta strand "Compared to HNP-2, HNP-3 contains one additional residue (Asp) at the N-terminus. The 3D structures remain the same. " "1DFN, 2PM4, 2PM5 resolved by X-ray." "Function: Defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. PTM: Contains three disulfide bonds 2-30; 4-19; 9-29." "[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(approximately 50% inbibition at 1 g/mL (290 nM)).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=6.20.9 ?g/ml), E. coli ATCC 25922 (vLD50=5.92.1 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=419.2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=132.1 ?g/ml), S. aureus ATCC 29213 (vLD50=2.20.4 ?g/ml), Bacillus cereus ATCC 10876 (vLD50=0.370.08 ?g/ml).(Ref.2)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization(Cys2 and Cys30). "Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29." L No cytotoxicity information found in the reference(s) presented Not found 34206990##4056036##15616305 Viruses. 2021 Jun 26;13(7):1246.##J Clin Invest. 1985 Oct;76(4):1436-1439.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. "Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI.##Ericksen B, Wu Z, Lu W, Lehrer RI." Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Primary structures of three human neutrophil defensins.##Antibacterial activity and specificity of the six human {alpha}-defensins. DRAMP03594 VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV 33 "Neutrophil defensin 4 (Defensin, alpha 4; HNP-4, HP-4; Human, mammals, animals)" P12838 Belongs to the alpha-defensin family DEFA4 Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)" Protein level Beta strand "Compared to HNP-2, HNP-1 contains one additional residue (Ala) at the N-terminus. It contains a long stretch of a double-stranded antiparallel beta-sheet in a hairpin conformation that contains a beta-bulge, a short region of triple-stranded beta-sheet, and several tight turns." 1ZMM resolved by X-ray. "Function: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). In comparison with HNP1-3, inhibition of both strains of HIV-1 by HNP4 was noticeably stronger as evidenced by lower IC50 values (2-5 ?M) and steeper and more complete inhibition curves. PTM: Contains three disulfide bonds 2-30; 4-19; 9-29." "[Ref.34206990]Virus:showed inhibition against SARS-CoV-2.Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=3.30.4 ?g/ml), E. coli ATCC 25922 (vLD50=3.00.7 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=6.60.2 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=7.31.4 ?g/ml), S. aureus ATCC 29213 (vLD50=7.20.2 ?g/ml), Bacillus cereus ATCC 10876 (vLD50=0.870.08 ?g/ml).(Ref.4)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s).##Yeast: Candida albicans ATCC 99788 amphotericin B resistant (IC90>100 ?g/ml).(Ref.2)" No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29." L No cytotoxicity information found in the reference(s) presented Not found 34206990##17088326##15620707##15616305 Viruses. 2021 Jun 26;13(7):1246.##Protein Sci. 2006 Dec;15(12):2749-2760.##FEBS Lett. 2005 Jan 3;579(1):162-166.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. "Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J.##Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, Lehrer RI, Lu W.##Ericksen B, Wu Z, Lu W, Lehrer RI." "Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Crystal structures of human alpha-defensins HNP4, HD5, and HD6.##Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.##Antibacterial activity and specificity of the six human {alpha}-defensins." DRAMP03595 ATCYCRTGRCATRESLSGVCEISGRLYRLCCR 32 "Human defensin-5 (HD-5; Defensin, alpha 5; Human, mammals, animals)" "Q01523, A0JDY6, Q3KNV2" Belongs to the alpha-defensin family DEFA5 Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)" Protein level Beta strand The L- and D-forms of HD-5 are equally active than E.coli but not S. aureus (Wei G et al 2009 JBC 284: 29180-92). 1ZMP resolved by X-ray. "Function: Antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Tissue specificity: Paneth cells of the small intestine (at protein level). PTM: Contains three disulfide bonds." "[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(60% inhibition at 12.5 g/mL (3.45 M));SARS-CoV-2 variant P.1:inhibition of infection in HeLa-hACE2 cells(72% inbibition at 50 g/mL);SARS-CoV-2 variant B.1.1.7:inhibition of infection in HeLa-hACE2 cells(32% inbibition at 50 g/mL).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=2.50.3 ?g/ml), E. coli ATCC 25922 (vLD50=2.10.9 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=5.50.5 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=6.30.5 ?g/ml), S. aureus ATCC 29213 (vLD50=3.20.3 ?g/ml), Bacillus cereus ATCC 10876 (vLD50<0.31 ?g/ml).(Ref.2)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s)." [Ref.26206286] It has 0% hemolysis at 100M against human red blood cells. Cyclic Free Free "Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30." L [Ref.34206990]No cytotoxicity on HEK293T cells up to 50 g/mL. Not found 34206990##12021776##15616305##26206286 Viruses. 2021 Jun 26;13(7):1246.##Nat Immunol. 2002 Jun;3(6):583-590.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275.##Peptides. 2015 Sep;71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20. "Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL.##Ericksen B, Wu Z, Lu W, Lehrer RI.##Basil Mathew Ramakrishnan Nagaraj" Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Paneth cell trypsin is the processing enzyme for human defensin-5.##Antibacterial activity and specificity of the six human {alpha}-defensins.##Antimicrobial activity of human -defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs DRAMP03596 AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL 32 "Human defensin-6 (HD-6; Defensin, alpha 6; Human, mammals, animals)" Q01524 Belongs to the alpha-defensin family DEFA6 Homo sapiens (Human) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2)" Protein level Beta strand (3 strands; 19 residues) Not found "1ZMQ, 3QTE resolved by X-ray." "Function: Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1. Subunit structure: Homodimer. Tissue specificity: Paneth cells of the small intestine. PTM: Contains three disulfide bonds." "[Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(HD6 only blocked SARS-CoV-2 infection at the highest concentration tested (50 g/mL, 13 M)).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50>256 ?g/ml), E. coli ATCC 25922 (vLD50=10314 ?g/ml), Enterobacter aerogenes ATCC 13048 (vLD50=15611 ?g/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50>256 ?g/ml), S. aureus ATCC 29213 (vLD50>256 ?g/ml), Bacillus cereus ATCC 10876 (vLD50=2513 ?g/ml).(Ref.3)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bonds between Cys4 and Cys31,Cys6 and Cys20,Cys10 and Cys30." L [Ref.34206990]No cytotoxicity on HEK293T cells up to 50 g/mL. Not found 34206990##8417977##17088326##15616305 Viruses. 2021 Jun 26;13(7):1246.##FEBS Lett. 1993; 315:187-192.##Protein Sci. 2006 Dec;15(12):2749-2760.##Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. "Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL.##Jones DE, Bevins CL.##Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J.##Ericksen B, Wu Z, Lu W, Lehrer RI." "Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry.##Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel.##Crystal structures of human alpha-defensins HNP4, HD5, and HD6.##Antibacterial activity and specificity of the six human {alpha}-defensins." DRAMP03637 ATFNFINNCPFTVWAAAVPG 20 Thaumatin-like protein (Actc2) P83958 Belongs to the thaumatin family tlp Actinidia chinensis (Kiwi) (Yangtao) "Antimicrobial, Antifungal, Antiviral" Protein level Not found Not found None Function: Has antifungal activity. Inhibits HIV-1 reverse transcriptase. "Botrytis cinerea, Coprinus comatus, Mycosphaerella arachidicola, Physalospora piricola, Candida albicans, Saccharomyces carlsbergensis, HIV-1 reverse transcriptase." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12165295##12417892##15536427 Phytochemistry. 2002 Sep;61(1):1-6.##J Allergy Clin Immunol. 2002 Nov;110(5):805-810.##J Allergy Clin Immunol. 2004 Nov;114(5):1169-1175. "Wang H, Ng TB.##Gavrovi?-Jankulovi? M, ?Irkovi? T, Vuckovi? O, Atanaskovi?-Markovi? M, Petersen A, Gojgi? G, Burazer L, Jankov RM.##Bublin M, Mari A, Ebner C, Knulst A, Scheiner O, Hoffmann-Sommergruber K, Breiteneder H, Radauer C." Isolation of an antifungal thaumatin-like protein from kiwi fruits.##Isolation and biochemical characterization of a thaumatin-like kiwi allergen.##IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries. DRAMP03712 IFKAIWSGIKSLF 13 "Peptide Hp1090 (Non-disulfide-bridged peptide 5.9, NDBP-5.9; Arthropods, animals)" P0DJ02 Belongs to the scorpion NDBP 5 family Not found Heterometrus petersii (Asian forest scorpion) "Antimicrobial, Antibacterial, Antiviral" Transcript level Alpha helix (CD) CD spectroscopy analysis indicates that Hp1090 is an amphipathic -helical peptide that prevents the initiation of HCV infection by directly interactingwith viral particles and rapidly permeabilizing their phospholipid membranes. None "Function: The peptide showed antibacterial activity against both Gram-negative and Gram-positive bacteria. Tissue specificity: Expressed by the venom gland. Miscellaneous: This peptide has a significant inhibitory effect on hepatitis C virus (HCV) infection (IC50=7.62 ?g/ml). Furthermore, this peptide potently inhibits HCV before viral entry into cells and kills HCV rapidly in vitro. PTM: C-terminal amidation (By similarity)." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Binding to HCV 20950663 Peptides. 2011 Jan;32(1):11-19. "Yan R, Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z, Zheng C, Li W." A new natural alpha-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV. DRAMP03755 QFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS 37 "Potassium channel toxin alpha-KTx 1.1 (ChTX-Lq1; charybdotoxin; Arthropods, animals)" P13487 Not found Not found Leiurus quinquestriatus hebraeus (Yellow scorpion) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral" Protein level Combine helix and strand structure These structures show that charybdotoxin is composed of a beta-sheet linked to an alpha-helix by two disulphide bridges and to an extended fragment by the third disulphide bridge. "1BAH, 2CRD resolved by NMR." "Function: Potent selective inhibitor of high conductance (maxi-K), different medium and small conductance calcium-activated potassium channels (KCa/KCNM), as well as a voltage-dependent potassium channel (Kv1.3/KCNA3). It appears to block channel activity by a simple bimolecular inhibition process. Tissue specificity: Expressed by the venom gland. Domain: Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). PTM: Contains three disulfide bonds." "Gram-positive bacteria: B.subtilis, S.aureus;##Gram-negative bacterium: E.coli.##Yeast: Candida albicans. " No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15118082##1705886##9092804##1380828 Proc Natl Acad Sci U S A. 2004 May 11;101(19):7363-7368.##Eur J Biochem. 1991 Feb 26;196(1):19-28.##Biochemistry. 1997 Apr 1;36(13):3760-3766.##Biochemistry. 1992 Sep 1;31(34):7756-7764. "Yount NY, Yeaman MR.##Bontems F, Roumestand C, Boyot P, Gilquin B, Doljansky Y, Menez A, Toma F.##Song J, Gilquin B, Jamin N, Drakopoulou E, Guenneugues M, Dauplais M, Vita C, Mnez A.##Bontems F, Gilquin B, Roumestand C, Mnez A, Toma F." Multidimensional signatures in antimicrobial peptides.##Three-dimensional structure of natural charybdotoxin in aqueous solution by 1H-NMR. Charybdotoxin possesses a structural motif found in other scorpion toxins.##NMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packing.##Analysis of side-chain organization on a refined model of charybdotoxin: structural and functional i DRAMP03778 ANDPQCLYGNVAAKF 15 Agrocybin (Fungus) P84797 Not found Not found Agrocybe cylindracea (Toadstool) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Not found Not found None Function: Has mitogenic activity towards murine splenocytes. Lacks antiproliferative activity towards HepG2 hepatoma cells. "Mycosphaerella arachidicola (IC50=125 ?M), HIV-1 reverse transcriptase (IC50=60 ?M), Pseudomonas fluorescens." No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15629530 Peptides. 2005 Feb;26(2):191-196. "Ngai PH, Zhao Z, Ng TB." "Agrocybin, an antifungal peptide from the edible mushroom Agrocybe cylindracea." DRAMP03783 QWGYGGMPYGGYGGMGGYGMGGYGMGYRRRMWGSPYGGYGGYGGYGGWG 49 "Neuropeptide-like protein 27 (NLP-27; Gly-rich, Tyr-rich; nematodes, animals; Predicted)" No entry found Not found Not found Caenorhabditis elegans "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15048112 Nat Immunol. 2004 May;5(5):488-494. "Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ." "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM." DRAMP03784 QWGYGGYGRGYGGYGGYGRGMYGGYGRGMYGGYGRGMYGGWGK 43 "Neuropeptide-like protein 28 (NLP-28; Gly-rich, Tyr-rich; nematodes, animals; Predicted)" No entry found Not found Not found Caenorhabditis elegans "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15048112 Nat Immunol. 2004 May;5(5):488-494. "Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ." "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM." DRAMP03786 QWGYGGYGRGYGGYGGYGRGYGGYGRGYGGYGRGMWGRPYGGYGWGK 47 "Neuropeptide-like protein 30 (NLP-30; Gly-rich, Tyr-rich; nematodes, animals; Predicted)" No entry found Not found Not found Caenorhabditis elegans "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15048112 Nat Immunol. 2004 May;5(5):488-494. "Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ." "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM." DRAMP03791 QWGYNSYGYGNYGGYGGYPMYGGYGMNGGYGGGGLLGMFLGKKK 44 "Caenacin-1 (Gly-rich, Tyr-rich; CNC-1; nematode, invertebrate, animals)" No entry found Not found Not found Caenorhabditis elegans "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15048112 Nat Immunol. 2004 May;5(5):488-494. "Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ." "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM." DRAMP03792 QYGYGGYPGMMGGYGGYPGMMGGYGMRPYGMGYGMGMGGMGMYRPGLLGMLMGK 54 "Caenacin-2 (Gly-rich, Tyr-rich; CNC-2, nematode, invertebrate, animals)" No entry found Not found Not found Caenorhabditis elegans "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15048112 Nat Immunol. 2004 May;5(5):488-494. "Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ." "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM." DRAMP03793 QYGYGPMMGGYGPGMMGGYGPGMMGGYGPGMMGGYGPGMMGGYGMSPMYGGYGMYRPGLLGMLLG 65 "Caenacin-3 (Gly-rich, Tyr-rich; CNC-3, nematode, invertebrate, animals)" No entry found Not found Not found Caenorhabditis elegans "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15048112 Nat Immunol. 2004 May;5(5):488-494. "Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ." "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM." DRAMP03794 QWGYGPYGGYGGGYPGMYGGYGMRPYGMYGGYGMGMYRPGLLGMLIGK 48 "Caenacin-4 (Gly-rich, Tyr-rich; CNC-4, nematode, invertebrate, animals)" No entry found Not found Not found Caenorhabditis elegans "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15048112 Nat Immunol. 2004 May;5(5):488-494. "Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ." "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM." DRAMP03795 QWGYNSYGGYNSYGNYGGYGGGYNNGYGVNANLGVGGRGG 40 "Caenacin-5 (Gly-rich, Tyr-rich; CNC-5, nematode, invertebrate, animals)" No entry found Not found Not found Caenorhabditis elegans "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 15048112 Nat Immunol. 2004 May;5(5):488-494. "Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ." "TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM." DRAMP03804 VVCACRRALCLPRERRAGFCRIRGRIHPLCCRR 33 "Corticostatin-3 (Corticostatin III; Macrophage antibiotic peptide MCP-1; lagomorphs, mammals, ani" P01376 Belongs to the alpha-defensin family Not found Oryctolagus cuniculus (Rabbit) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Bridge Not found None "Function: This peptide has antibiotic, anti-fungi and antiviral activity. It also inhibits corticotropin (ACTH) stimulated corticosterone production. PTM: Contains three disulfide bonds (By similarity)." herpes simplex virus type I No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 6643497##3988726##1311240 J Immunol. 1989 Aug 15;143(4):1358-1365.##J Biol Chem. 1985 Apr 25;260(8):4579-4584.##Endocrinology. 1992 Mar;130(3):1413-1423. "Ganz T, Rayner JR, Valore EV, Tumolo A, Talmadge K, Fuller F.##Selsted ME, Brown DM, DeLange RJ, Harwig SS, Lehrer RI.##Zhu Q, Solomon S." The structure of the Rabbit macrophage defensin genes and their organ-specific expression.##Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.##Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides. DRAMP03805 VVCACRRALCLPLERRAGFCRIRGRIHPLCCRR 33 "Corticostatin-4 (Corticostatin IV; Macrophage antibiotic peptide MCP-2; lagomorphs, mammals, anim" P01377 Belongs to the alpha-defensin family Not found Oryctolagus cuniculus (Rabbit) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Protein level Bridge Not found None "Function: This peptide has antibiotic, anti-fungi and antiviral activity. It also inhibits corticotropin (ACTH) stimulated corticosterone production. PTM: Problely contains three disulfide bonds 3-31; 5-20; 10-30." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Cell membrane 6643497##3988726##1311240 J Biol Chem. 1983 Dec 10;258(23):14485-14489.##J Biol Chem. 1985 Apr 25;260(8):4579-4584.##Endocrinology. 1992 Mar;130(3):1413-1423. "Selsted ME, Brown DM, DeLange RJ, Lehrer RI.##Selsted ME, Brown DM, DeLange RJ, Harwig SS, Lehrer RI.##Zhu Q, Solomon S." "Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of Rabbit lung macrophages.##Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.##Isolation and mode of action of rabbit corticostatic (antiadrenocorticotrop" DRAMP04006 GLVSGLLNTAGGLLGDLLGSLGSLSGGES 29 "Plasticin-A1 (PTC-A1; DRP-AA-2-5; frogs, amphibians, animals)" No entry found Not found Not found Agalychnis annae (AA) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 9774745 Biochim Biophys Acta. 1998 Oct 14;1388(1):279-283. Wechselberger C. Cloning of cDNAs encoding new peptides of the dermaseptin-family. DRAMP04008 GLLSGILNTAGGLLGNLIGSLSN 23 "Plasticin-C1 (PTC-C1; DRP-AC-1; frogs, amphibians, animals)" No entry found Not found Not found Agalychnis callidryas "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12709067 Eur J Biochem. 2003 May;270(9):2068-2081. "Vanhoye D, Bruston F, Nicolas P, Amiche M." Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain. DRAMP04009 GLLSGILNSAGGLLGNLIGSLSN 23 "Plasticin-C2 (PTC-C2; DRP-AC-2; frogs, amphibians, animals)" No entry found Not found Not found Agalychnis callidryas "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 12709067 Eur J Biochem. 2003 May;270(9):2068-2081. "Vanhoye D, Bruston F, Nicolas P, Amiche M." Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain. DRAMP04010 GLVSDLLSTVTGLLGNLGGGGLKKI 25 "Plasticin-S1 (PTC-S1; frogs, amphibians, animals)" No entry found Not found Not found Synthetic construct "Antimicrobial, Antibacterial, Antifungal, Antiviral" Predicted Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18644413 Peptides. 2008 Nov;29(11):2074-2082. "Amiche M, Ladram A, Nicolas P." A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. DRAMP04398 AKYTGKCTKSKNECKYKNDAGKDTFIKCPKFDNKKCTKDNNKCTVDTYNNAVDCD 55 Antifungal protein (PAF) Q01701 Not found paf Penicillium chrysogenum (Penicillium notatum) "Antimicrobial, Antifungal, Antiviral" Protein level Beta strand (5 strands; 24 residues) PAF comprises five beta-strands forming two orthogonally packed beta-sheets that share a common interface. 2KCN resolved by NMR. Function: It exhibits antifungal activity. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19459942##8566771 FEBS J. 2009 May;276(10):2875-2890.##Gene. 1995 Dec 29;167(1-2):167-171. "Batta G, Barna T, Gspri Z, Sndor S, K?vr KE, Binder U, Sarg B, Kaiserer L, Chhillar AK, Eigentler A, Leiter E, Hegeds N, Pcsi I, Lindner H, Marx F.##Marx F, Haas H, Reindl M, St?ffler G, Lottspeich F, Redl B." "Functional aspects of the solution structure and dynamics of PAF--a highly-stable antifungal protein from Penicillium chrysogenum.##oning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity." DRAMP04503 GILTDTLKGAAKNVAGVLLDKLKCKITGGC 30 "Pelophylaxin-1 (Frogs, amphibians, animals)" Q2WCN8 Not found pelophylaxin-1 Pelophylax plancyi fukienensis (Fukien gold-striped pond frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Homology Not found Not found None Function: Amphibian defense peptide. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16139927 Peptides. 2006 Jan;27(1):36-41. "Zhou M, Chen T, Walker B, Shaw C." "Pelophylaxins: novel antimicrobial peptide homologs from the skin secretion of the Fukien gold-striped pond frog, Pelophylax plancyi fukienensis: identification by ""shotgun"" cDNA cloning and sequence analysis." DRAMP04504 GILLNTLKGAAKNVAGVLLDKLKCKITGGC 30 "Pelophylaxin-2 (Frogs, amphibians, animals)" Q2WCN7 Not found pelophylaxin-2 Pelophylax plancyi fukienensis (Fukien gold-striped pond frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Homology Not found Not found None Function: Amphibian defense peptide. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16139927 Peptides. 2006 Jan;27(1):36-41. "Zhou M, Chen T, Walker B, Shaw C." "Pelophylaxins: novel antimicrobial peptide homologs from the skin secretion of the Fukien gold-striped pond frog, Pelophylax plancyi fukienensis: identification by ""shotgun"" cDNA cloning and sequence analysis." DRAMP04505 GLMDSLKGLAATAGKTVLQGLLKTASCKLEKTC 33 "Pelophylaxin-3 (Frogs, amphibians, animals)" Q2WCN6 Not found pelophylaxin-3 Pelophylax plancyi fukienensis (Fukien gold-striped pond frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Homology Not found Not found None Function: Amphibian defense peptide. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16139927 Peptides. 2006 Jan;27(1):36-41. "Zhou M, Chen T, Walker B, Shaw C." "Pelophylaxins: novel antimicrobial peptide homologs from the skin secretion of the Fukien gold-striped pond frog, Pelophylax plancyi fukienensis: identification by ""shotgun"" cDNA cloning and sequence analysis." DRAMP04506 ILPFLAGLFSKIL 13 "Pelophylaxin-4 (Frogs, amphibians, animals)" Q2WCN5 Not found pelophylaxin-4 Pelophylax plancyi fukienensis (Fukien gold-striped pond frog) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Homology Not found Not found None Function: Amphibian defense peptide. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 16139927 Peptides. 2006 Jan;27(1):36-41. "Zhou M, Chen T, Walker B, Shaw C." "Pelophylaxins: novel antimicrobial peptide homologs from the skin secretion of the Fukien gold-striped pond frog, Pelophylax plancyi fukienensis: identification by ""shotgun"" cDNA cloning and sequence analysis." DRAMP04564 FIFHIIKGLFHAGKMIHGLVTRRRH 25 "Epinecidin-1 (Epi-1; fish, animals)" No entry found Not found Not found Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus) "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17570764 DNA Cell Biol. 2007 Jun;26(6):403-413. "Pan CY, Chen JY, Cheng YS, Chen CY, Ni IH, Sheen JF, Pan YL, Kuo CM." "Gene expression and localization of the epinecidin-1 antimicrobial peptide in the grouper (Epinephelus coioides), and its role in protecting fish against pathogenic infection." DRAMP04582 IFGSIYHRKCVVKNRCETVSGHKTCKDLTCCRAVIFRHERPEVCRPQT 48 "Strongylocin 1 (Cys-rich; sea urchin, Echinoidea, animals)" No entry found Not found Not found Strongylocentrotus droebachiensis "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18656496 Dev Comp Immunol. 2008;32(12):1430-1440. "Li C, Haug T, Styrvold OB, J?rgensen T?, Stensv?g K." "Strongylocins, novel antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis." DRAMP04584 IFNSIYHRKCVVKNRCETVSGHKTCKDLTCCRAVIFRHERPEVCRPST 48 "SpStrongylocin 1 (S. purpuratus Strongylocin, sea urchin, Echinoidea, animals)" No entry found Not found Not found Strongylocentrotus purpuratus "Antimicrobial, Antibacterial, Antifungal, Antiviral" Not found Not found Not found None Comment: No comments found on DRAMP database No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 19852980 Dev Comp Immunol. 2010 Mar;34(3):286-292. "Li C, Blencke HM, Smith LC, Karp MT, Stensv?g K." "Two recombinant peptides, SpStrongylocins 1 and 2, from Strongylocentrotus purpuratus, show antimicrobial activity against Gram-positive and Gram-negative bacteria." DRAMP04674 VYINKLTPPCGTMYYACEAV 20 Antiviral protein Y3 (Fungi) P83477 Not found Not found Pleurotus citrinopileatus (Golden oyster mushroom) "Antimicrobial, Antiviral" Protein level Not found Not found None Miscellaneous: Has antiviral activity against Tobacco mosaic virus and antitumor activity against stomach cancer cells in vitro. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found PubMed ID is not available##6292726 Chinese J Biochem Mol Biol 2008; 24(7):597-603. "Wu LP, Wu ZJ, Lin D, Fang F, Lin QY, Xie LH." "Characterization and amino acid sequence of y3, an antiviral protein from mushroom Coprinus comatus." DRAMP04681 VIAGGXAAIIG 11 Antiviral serine protease P86931 Not found Not found Eisenia foetida (Common brandling worm) (Common dung-worm) "Antimicrobial, Antiviral" Protein level Not found Not found None Function: Serine protease which has antiviral activity against cucumber mosaic virus and tobacco mosaic virus. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 18775500 Comp Biochem Physiol B Biochem Mol Biol. 2008 Dec;151(4):381-385. "Ueda M, Noda K, Nakazawa M, Miyatake K, Ohki S, Sakaguchi M, Inouye K." "A novel anti-plant viral protein from coelomic fluid of the earthworm Eisenia foetida: purification, characterization and its identification as a serine protease." DRAMP04682 QGRMYQRFLRQHVDPDETGGNDHYLNLSRRNIQCPNRHEGVRFNTDIHEDLTNRRPIDEHEGVVRVTDKTEEG 73 Lactogenin P59761 Belongs to the pancreatic ribonuclease family Not found Bos taurus (Bovine) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: Secretory RNase specific towards pyrimidine bases, with higher activity towards poly C than poly U. Inhibits cell-free translation. Miscellaneous: Inhibits HIV-1 reverse transcriptase in vitro." No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 10486275 Biochem Biophys Res Commun. 1999 Sep 16;263(1):187-191. "Ye XY, Cheng KJ, Ng TB." Isolation and characterization of angiogenin-1 and a novel protein designated lactogenin from bovine milk. DRAMP04683 SMIGGVMSKG 10 NADPH oxidoreductase P84517 Not found Not found Bombyx mori (Silk moth) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: NADPH oxidoreductase. Has antiviral activity against BmNPV. Miscellaneous: Expressed at high levels in BmNPV-resistant strains. Expressed at lower levels in moderately resistant and susceptible strains. " No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 17213661 Biosci Biotechnol Biochem. 2007 Jan;71(1):200-205. "Selot R, Kumar V, Shukla S, Chandrakuntal K, Brahmaraju M, Dandin SB, Laloraya M, Kumar PG." Identification of a soluble NADPH oxidoreductase (BmNOX) with antiviral activities in the gut juice of Bombyx mori. DRAMP04693 GSPRTEYEACRVRCQVAEHGVERQRRCQQVCEKRLREREGRRE 43 Luffin P1c (one chain of ribosome-inactivating protein luffin P1; Plant defensin) "P56568, Q8GRS9" Not found Not found Luffa aegyptiaca (Sponge gourd) (Luffa cylindrica) "Antimicrobial, Antiviral, Toxin" Protein level Alpha helix "Nuclear magnetic resonance spectroscopy revealed that the Luffin P1 comprises a helix-loop-helix motif, with the two alpha helices tightly associated by two disulfide bonds.(Ref.2)" 2L37 resolved by NMR. Function: Inhibits protein synthesis in animal cells. No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Free "Disulfide bond between Cys10 and Cys31,Cys14 and Cys27." L [Ref.21195767] It exhibited ytotoxicity against uninfected C8166 cell line (IC50=235 M). EC50 of the inhibition of syncytia formation and p24 antigen production were 50 M (262 g/ml) and 58 M (306 g/ml). Not found 9214759##21195767 Biosci Biotechnol Biochem. 1997 Jun;61(6):984-988.##J Struct Biol. 2011 Apr;174(1):164-172. "Kimura M, Park SS, Sakai R, Yamasaki N, Funatsu G.##Ng YM, Yang Y, Sze KH, Zhang X, Zheng YT, Shaw PC." Primary structure of 6.5k-arginine/glutamate-rich polypeptide from the seeds of sponge gourd (Luffa cylindrica).##Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrica). DRAMP18133 NRILPTLIGPL 11 Peptide Ctri9819 P0DMG0 Not found Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Transcript level Not found Not found None Function: Antimicrobial peptide (By similarity).##Miscellaneous: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells (PubMed: 23415044). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials 34:3511-3522 (2013). "Hong W., Zhang R., Di Z., He Y., Zhao Z., Hu J., Wu Y., Li W., Cao Z." Design of histidine-rich peptides with enhanced bioavailability andinhibitory activity against hepatitis C viruS. DRAMP18134 INWDILIDTIKDKL 14 Peptide Ctri9677 P0DMF9 Not found Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Transcript level Not found Not found None Function: Antimicrobial peptide (By similarity).##Miscellaneous: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells (PubMed: 23415045). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials 34:3511-3522 (2013). "Hong W., Zhang R., Di Z., He Y., Zhao Z., Hu J., Wu Y., Li W., Cao Z." Design of histidine-rich peptides with enhanced bioavailability andinhibitory activity against hepatitis C viruS. DRAMP18137 ILSYLWNGIKSIF 13 Peptide Hp1239 (Non-disulfide-bridged peptide 5; NDBP-5) P0DME8 Belongs to the scorpion NDBP 5 family Not found Heterometrus petersii (Asian forest scorpion) "Antimicrobial, Antibacterial, Antiviral" Transcript level Not found Not found None "Function: Amphipathic peptide with antibacterial activities (By similarity). Shows antiviral activities against the herpes simplex virus type-1. It potently inhibits the initial infection by provoking the rupture of viral envelop and the dissociation of proteins from the virions (EC (50) is 0.41 ??M). It also effectively inhibits viral attachment (EC (50) is 5.73 ??M), viral entry (EC (50) is 4.32 ??M) and viral proliferation after infection (EC (50) is 8.41 ??M). Morever, it enters mammalian tested cells (Vero) and reduces the intracellular infectivity." CC50=26.15 ? 1.91 ??M; HC50= 33.32 ? 0.96 ??M; EC50=0.41 ? 0.06 ??M No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20443192##24315793 Proteomics 10:2471-2485 (2010).##Antiviral ReS. 102:1-10 (2014). "Ma Y., Zhao Y., Zhao R., Zhang W., He Y., Wu Y., Cao Z., Guo L., Li W.##Hong W., Li T., Song Y., Zhang R., Zeng Z., Han S. , Zhang X., Wu Y., Li W., Cao Z." Molecular diversity of toxic components from the scorpionHeterometrus petersii venom revealed by proteomic and transcriptomeanalysiS. ##Inhibitory activity and mechanism of two scorpion venom peptidesagainst herpes simplex virus type 1. DRAMP18139 ILGKIWEGIKSIF 13 Peptide Hp1036 (Non-disulfide-bridged peptide 5; NDBP-5) P0DME6 Belongs to the scorpion NDBP 5 family Not found Heterometrus petersii (Asian forest scorpion) "Antimicrobial, Antibacterial, Antiviral" Transcript level Not found Not found None "Function: Amphipathic peptide with antibacterial activities (By similarity). Shows antiviral activities against the herpes simplex virus type-1. It potently inhibits the initial infection by provoking the rupture of viral envelop and the dissociation of proteins from the virions (EC (50) is 0.43 ??M). It also effectively inhibits viral attachment (EC (50) is 2.87 ??M), viral entry (EC (50) is 4.29 ??M) and viral proliferation after infection (EC (50) is 7.86). Morever, it enters mammalian tested cells (Vero) and reduces the intracellular infectivity." CC50=46.71 ? 3.80 ??M; HC50=34.91 ? 0.47 ??M; EC50=0.43 ? 0.09 ??M No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 20443192##24315793 Proteomics 10:2471-2485 (2010).##Antiviral ReS. 102:1-10 (2014). "Ma Y., Zhao Y., Zhao R., Zhang W., He Y., Wu Y., Cao Z., Guo L., Li W.##Hong W., Li T., Song Y., Zhang R., Zeng Z., Han S. , Zhang X., Wu Y., Li W., Cao Z." Molecular diversity of toxic components from the scorpionHeterometrus petersii venom revealed by proteomic and transcriptomeanalysiS. ##Inhibitory activity and mechanism of two scorpion venom peptidesagainst herpes simplex virus type 1. DRAMP18423 EEESEVAHLRVRRGFGCPLNQGACHRHCRSIRRRGGYCSGIIKQTCTCYRN 51 "HEdefensin (arachnids, Chelicerata, arthropods, invertebrates, animals)" No entry found Not found Not found "hemolymph, Haemaphysalis longicornis" "Antimicrobial, Antiviral" Bridge Not found None Fuction: The synthetic peptide showed virucidal activity against Langat virus (LGTV). No MICs found in DRAMP database No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 27871830 Dev Comp Immunol. 2017 Mar;68:98-107 "Talactac MR, Yada Y, Yoshii K, Hernandez EP, Kusakisako K, Hiroki M, Galay RL, Fujisaki K, Mochizuki M, Tanaka T" "Characterization and antiviral activity of a newly identified defensin-like peptide, HEdefensin, in the hard tick Haemaphysalis longicornis" DRAMP02257 LMDTVKNVAKNLAGHMLDKLKCKITGC 27 "Ranatuerin-2P (Ranatuerin 2P; Frogs, amphibians, animals)" "Q8QFQ4, P82847" Belongs to the frog skin active peptide family (Brevinin subfamily) Not found Rana pipiens (Northern leopard frog) "Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal,Antiviral" Protein level Not found Not found None "Function: Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi." [Ref.10651828] Gram-positive bacteria: Staphylococcus aureus (MIC=50 ?M);##Gram-negative bacterium: Escherichia coli (MIC=13 ?M);##Yeast: Candida albicans (MIC=67 ?M).##[Ref.11601906]Virus:##Frog Virus 3: 90% inhibition at 500 ?M;##Channel Catfish Virus: 99% inhibition at 50 ?M. No hemolysis information or data found in the reference(s) presented in this entry Cyclic Free Cyclization of a C-terminal Cys residue (forming a disulfide bond) There is a disulfide bond between Cys22 and Cys27. L No cytotoxicity information found in the reference(s) presented Not found 11601906##10651828 Virology. 2001 Sep 30;288(2):351-7.##Eur J Biochem. 2000 Feb;267(3):894-900. "Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L.##Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM." "Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin.##Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens." DRAMP18680 GIADILKGLL 10 "Ctry2146 (Scorpions, animals)" P0DMF1 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tryznai (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18681 LLGGLLQSLL 10 "Ctry2346 (Scorpions, animals)" P0DMF2 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tryznai (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E-01% and 1.E+00% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18682 GILDAITGLL 10 "Ctry2606 (Scorpions, animals)" P0DMF4 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tryznai (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E-03% and 1.E-02% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18683 YIRDFITRRPPFGNI 15 "Ctri9194 (Scorpions, animals)" P0DMF5 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18684 GILDALTGIL 10 "Ctri9293 (Scorpions, animals)" P0DMF6 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18685 GVVDTLKNLLMGLL 14 "Ctri9594 (Scorpions, animals)" P0DMF7 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E-01% and 1.E+00% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18686 FLFNVIPHAINATASLIKK 19 "Ctri9610 (Scorpions, animals)" P0DME2 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E-01% and 1.E+00% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18687 FLVGILPRMRGFITPFLKKVR 21 "Ctri10033 (Scorpions, animals)" P0DME4 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18688 FLWSLIPSAISAVTSLIKK 19 "Ctri10036 (Scorpions, animals)" P0DME3 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP18689 FDLGGLIKGVVDLF 14 "Ctri10261 (Scorpions, animals)" P0DMF8 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short ant Not found Chaerilus tricostatus (Scorpion) "Antimicrobial, Antiviral" Not found Not found Not found None "Function: Shows a low ability to inhibit hepatitis C virus (HCV) infection in Huh7.5.1 cells. Tissue specificity: Expressed by the venom gland." [Ref.23415044] The HCV RNA level is screened that between 1.E+00% and 1.E+01% of control(IFN.2a) in Huh7.5.1 cells. No hemolysis information or data found in the reference(s) presented in this entry Not included yet Not included yet Not included yet Not included yet Not included yet Not included yet Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP20775 FLGFLKNLF 9 "Ctry2459-WT (Ctry2459, scorpions,animals)" P0DMF3 Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family. Not found Chaerilus tryznai (Scorpion) "Antimicrobial, Antiviral" Protein level Not found Not found None "Function: Inhibit hepatitis C virus(HCV) infection via inactivating infectious viral particle. However, it cannot suppress established infection because of the poor cellular uptake and restriction of endosomes." [Ref.23415044] Virus: Hepatitis C virus (EC50=1.84 g/ml).##Cytotoxic: Huh7.5.1 cells (CC50=79.8 g/ml) [Ref.23415044] HC50 = 137.9 g/ml against human red blood cells. Linear Free Free None L [Ref.23415044] CC50=79.8 g/ml against Huh7.5.1 cells. Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP20908 FLHFLHHLF 9 "Ctry2459-H3 (Ctry2459 peptide derivative, His-rich)" No entry found Derived from the peptide Ctry2459 Not found Synthetic construct(from a scorpion venom peptide library) "Antimicrobial, Antiviral" Synthetic Not found Not found None "Function: Inhibits hepatitis C virus(HCV) infection via inactivating infectious viral particle. However, it cannot suppress established infection because of the poor cellular uptake and restriction of endosomes." [Ref.23415044] Virus: Hepatitis C virus ( EC50 = 0.85 g/ml ).##Cytotoxic: Huh7.5.1 cells (CC50>500 g/ml) [Ref.23415044] HC50 = 416.4 g/ml against human red blood cells. Linear Free Amidation None L [Ref.23415044] CC50>500 g/ml against Huh7.5.1 cells Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP20909 FLGFLHHLF 9 "Ctry2459-H2 (Ctry2459 peptide derivative, His-rich)" No entry found Derived from the peptide Ctry2460 Not found Synthetic construct( from a scorpion venom peptide library) "Antimicrobial, Antiviral" Synthetic Not found Not found None "Function: Inhibits hepatitis C virus(HCV) infection via inactivating infectious viral particle. However, it cannot suppress established infection because of the poor cellular uptake and restriction of endosomes." [Ref.23415044] Virus: Hepatitis C virus ( EC50 = 1.08 g/ml ).##Cytotoxic: Huh7.5.1 cells (CC50>500 g/ml) [Ref.23415044] HC50 = 203.3 g/ml against human red blood cells. Linear Free Amidation None L [Ref.23415044] CC50>500 g/ml against Huh7.5.1 cells Not found 23415044 Biomaterials. 2013 Apr;34(13):3511-22. "Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z." Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. DRAMP29151 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL 36 EK1 Q8BB25 Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Hemology Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.35087243]Virus:##SARS-CoV-2 Omicron:inhibition of cell-cell fusion in Calu-3 cells(IC50=119.68 nM);inhibition of cell-cell infusion in Caco2 cells(IC50=74.99 nM);inhibition of infection(Pseudovirus)(IC50=309.4 nM);inhibition of infection(Authentic)(IC50=1138 nM);##SARS-CoV-2 Delta:inhibition of cell-cell fusion(IC50=131.8?nM);inhibition of infection(Pseudovirus)(IC50=427.55?nM);##SARS-CoV-2 D614G:inhibition of cell-cell fusion(IC50=314.6?nM);inhibition of infection(Pseudovirus)(IC50=414.85?nM).##[Ref.32231345]Virus:##SARS-CoV:ihibition of cell-cell fusion in Huh-7 cells(IC50=409.3 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=3237 nM);##MERS-CoV:ihibition of cell-cell fusion in Huh-7 cells(IC50=239.5 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=631.8 nM),inhibit the replication of MERS-CoV in VERO-E6 cells(IC50=802.1 nM);##HCoV-OC43:ihibition of cell-cell fusion in Huh-7 cells(IC50=787.6 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=1398 nM),inhibit the replication of HCoV-OC43 in RD cells(IC50=1554 nM);##HCoV-229E:ihibition of cell-cell fusion in Huh-7 cells(IC50=207.4 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=3963 nM),inhibit the replication of HCoV-229E in Huh-7 cells(IC50=4375 nM);##HCoV-NL63:ihibition of cell-cell fusion in Huh-7 cells(IC50=751.0 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=7666 nM),inhibit the replication of HCoV-NL63 in LLC-MK2 cells(IC50=3693 nM);##CoV-WIV1:ihibition of cell-cell fusion in Huh-7 cells(IC50=265.7 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=5425 nM);##CoV-Rs3367:ihibition of cell-cell fusion in Huh-7 cells(IC50=237.0 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=6014 nM);##CoV-SHC014:ihibition of cell-cell fusion in Huh-7 cells(IC50=279.6 nM);##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=286.7-315.0 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=2375.0 nM),inhibit the replication of MERS-CoV in VERO-E6 cells(IC50=2468 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented liposomes 35087243##32231345##30989115##32047258 Cell Res. 2022 Apr;32(4):404-406.##Cell Res. 2020 Apr;30(4):343-355.##Sci Adv. 2019 Apr 10;5(4):eaav4580.##Cell Mol Immunol. 2020 Jul;17(7):765-767. "Xia S, Chan JF, Wang L, Jiao F, Chik KK, Chu H, Lan Q, Xu W, Wang Q, Wang C, Yuen KY, Lu L, Jiang S.##Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L.##Xia S, Yan L, Xu W, Agrawal AS, Algaissi A, Tseng CK, Wang Q, Du L, Tan W, Wilson IA, Jiang S, Yang B, Lu L.##Xia S, Zhu Y, Liu M, Lan Q, Xu W, Wu Y, Ying T, Liu S, Shi Z, Jiang S, Lu L." Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant.##Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.##A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.##Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein. DRAMP29152 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL 36 EK1P Q8BB25 Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Hemology Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. [Ref.32231345]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=69.2 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG4-C(Palm) None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29153 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL 36 EK1C Q8BB25 Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Hemology Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32231345]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=37.3-48.1 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=139.4 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG4-C(Chol) None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29154 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL 36 EK1C1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32231345]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=56.8 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=480.3 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29155 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSG 39 EK1C2 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32231345]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=48.2 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=418.6 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29156 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSG 39 EK1C3 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32231345]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=10.6 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=86.4 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG4-Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29157 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1C4 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.35087243]Virus:##SARS-CoV-2 Omicron:inhibition of cell-cell fusion in Calu-3 cells(IC50=3.32 nM);inhibition of cell-cell infusion in Caco2 cells(IC50=0.88 nM);inhibition of infection(Pseudovirus)(IC50=8.63 nM);inhibition of infection(Authentic)(IC50=85.38 nM);##SARS-CoV-2 Delta:inhibition of cell-cell fusion(IC50=4.04?nM);inhibition of infection(Pseudovirus)(IC50=9.83?nM);##SARS-CoV-2 D614G:inhibition of cell-cell fusion(IC50=2.57?nM);inhibition of infection(Pseudovirus)(IC50=5.58?nM).##[Ref.32231345]Virus:##SARS-CoV:ihibition of cell-cell fusion in Huh-7 cells(IC50=4.3 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=11.7 nM);##MERS-CoV:ihibition of cell-cell fusion in Huh-7 cells(IC50=2.5 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=11.1 nM),inhibit the replication of MERS-CoV in VERO-E6 cells(IC50=4.2 nM);##HCoV-OC43:ihibition of cell-cell fusion in Huh-7 cells(IC50=7.7 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=37.7 nM),inhibit the replication of HCoV-OC43 in RD cells(IC50=24.8 nM);##HCoV-229E:ihibition of cell-cell fusion in Huh-7 cells(IC50=5.2 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=12.4 nM),inhibit the replication of HCoV-229E in Huh-7 cells(IC50=101.5 nM);##HCoV-NL63:ihibition of cell-cell fusion in Huh-7 cells(IC50=21.4 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=76.6 nM),inhibit the replication of HCoV-NL63 in LLC-MK2 cells(IC50=187.6 nM);##CoV-WIV1:ihibition of cell-cell fusion in Huh-7 cells(IC50=4.5 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=30.8 nM);##CoV-Rs3367:ihibition of cell-cell fusion in Huh-7 cells(IC50=8.1 nM),inhibition of Pseudovirus (PsV) infection in Huh-7 cells(IC50=66.9 nM);##CoV-SHC014:ihibition of cell-cell fusion in Huh-7 cells(IC50=4.3 nM);##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=1.3 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=15.8 nM),inhibit the replication of MERS-CoV in VERO-E6 cells(IC50=2468 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG4-Chol None L "[Ref.32231345]<10% cytotoxicity against VERO-E6 cells, RD cells, LLC-MK2 cells, Huh-7 cells up to 10000 nM." liposomes 35087243##32231345 Cell Res. 2022 Apr;32(4):404-406.##Cell Res. 2020 Apr;30(4):343-355. "Xia S, Chan JF, Wang L, Jiao F, Chik KK, Chu H, Lan Q, Xu W, Wang Q, Wang C, Yuen KY, Lu L, Jiang S.##Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant.##Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29158 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1C5 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32231345]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=3.1 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=31.3 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29159 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1C6 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32231345]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=3.9 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=77.4 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG12-Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29160 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1C7 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32231345]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=3.9 nM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=84.4 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG24-Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29161 LKVLLYEEFKLLESLIMEILEYQKDSDIKENAEDTK 36 EK1-scrambled No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32231345]Virus:SARS-CoV-2,SARS-CoV,MERS-CoV,HCoV-OC43,HCoV-229E,HCoV-NL63,CoV-WIV1,CoV-Rs3367,CoV-SHC014(No inhibition on the concentration up to 10 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented liposomes 32231345 Cell Res. 2020 Apr;30(4):343-355. "Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L." Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. DRAMP29162 NVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYGSGC 40 EKL1C No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "EKL1C is a Peptide-based pan-CoV fusion inhibitor,targets a highly conserved target site in HR1 domains in S protein of HCoVs." "[Ref.35087243]Virus:##SARS-CoV-2 Omicron:inhibition of cell-cell fusion in Calu-3 cells(IC50=12.18 nM);inhibition of cell-cell infusion in Caco2 cells(IC50=5.52 nM);inhibition of infection(Pseudovirus)(IC50=26.14 nM);inhibition of infection(Authentic)(IC50=182.2 nM);##SARS-CoV-2 Delta:inhibition of cell-cell fusion(IC50=14.42?nM);inhibition of infection(Pseudovirus)(IC50=31.99?nM);##SARS-CoV-2 D614G:inhibition of cell-cell fusion(IC50=11.77?nM);inhibition of infection(Pseudovirus)(IC50=23.6?nM).##[Ref.34367893]Virus:##SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.0450.006 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50=0.0370.009 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.0400.005 mol/L),inhibition of cell-cell fusion(IC50=0.0080.001 mol/L);inhibited authentic SARS-CoV-2 infection in Vero E6 cells(IC50=0.0030.001 mol/L);##SARS-CoV-2 variants(inhibition of Pseudovirus(PsV) infection):V341L(IC50=0.0470.013 mol/L);F342L(IC50=0.0260.007 mol/L);V367F(IC50=0.0660.012 mol/L);R408I(IC50=0.1480.012 mol/L);N435D(IC50=0.1350.013 mol/L);G476S(IC50=0.0650.008 mol/L);V483A(IC50=0.0780.011 mol/L);N501Y(IC50=0.0690.006 mol/L);D614G(IC50=0.1040.010 mol/L);12 mutations(P.1)(IC50=0.0460.006 mol/L);K417N-E484K-N501Y(IC50=0.1130.013 mol/L);8 mutations(B.1.1.7)(IC50=0.1200.009 mol/L);wide type(IC50=0.0490.007 mol/L);##inhibition of multiple HCoV Pseudovirus:SARS-CoV (IC50=0.0760.014 mol/L), MERS-CoV(IC50=0.0480.006 mol/L), HCoV-OC43(IC50=0.6680.081 mol/L), HCoV-NL63(IC50=0.0350.003 mol/L), SARSr-CoV-WIV1(IC50=0.2180.013 mol/L), and HCoV-Rs3367 (IC50=0.0460.003 mol/L),inhibition of authentic HCoV-OC43 infection in RD cells (IC50=0.2810.018 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L [Ref.34367893]Huh-7 cells:CC50=10 mol/L;Caco-2 cells:CC50=13.81 mol/L;293T/ACE2 cells:CC50=8.49 mol/L. liposomes 35087243##34367893 Cell Res. 2022 Apr;32(4):404-406.##Acta Pharm Sin B. 2021 Aug 2. "Xia S, Chan JF, Wang L, Jiao F, Chik KK, Chu H, Lan Q, Xu W, Wang Q, Wang C, Yuen KY, Lu L, Jiang S.##Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant.##A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29163 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1-C16 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None EK1-C16 at 0.31 M could effectively inhibit authentic SARS-CoV-2 WT infection. [Ref.35336956]Virus:##SARS-CoV-2 WT:inhibition of pseudovirus (PsV) infection in Caco2 cells(IC50=0.48 M);##SARS-CoV-2 Alpha:inhibition of pseudovirus (PsV) infection(IC50=0.19 M);##SARS-CoV-2 Beta:inhibition of pseudovirus (PsV) infection(IC50=0.43 M);##SARS-CoV-2 Gamma:inhibition of pseudovirus (PsV) infection(IC50=0.26 M);##SARS-CoV-2 Delta:inhibition of pseudovirus (PsV) infection(IC50=0.11 M);##SARS-CoV-2 Omicron:inhibition of pseudovirus (PsV) infection(IC50=0.23 M);inhibition of authentic infection in Vero-E6-TMPRSS-2 cells(IC50=0.75 M);##SARS-CoV:inhibition of pseudovirus (PsV) infection(IC50=0.17 M);##SARSr-CoV WIV1:inhibition of pseudovirus (PsV) infection(IC50=0.15 M);##SARSr-CoV Rs3367:inhibition of pseudovirus (PsV) infection(IC50=0.3 M);##MERS-CoV:inhibition of pseudovirus (PsV) infection in Caco2 cells(IC50=0.10 M);inhibition of cell-cell fusion(IC50=0.012 M);##HCoV-OC43:inhibition of authentic infection in RD cells(IC50=0.07 M);inhibition of cell-cell fusion(IC50=0.01 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG4-C16(palmitic acid) None L [Ref.35336956]showed no significant cytotoxicity against RD cells at the concentration of 5 M. Not found 35336956 Viruses. 2022 Mar 6;14(3):549. "Lan Q, Chan JF, Xu W, Wang L, Jiao F, Zhang G, Pu J, Zhou J, Xia S, Lu L, Yuen KY, Jiang S, Wang Q. " "A Palmitic Acid-Conjugated, Peptide-Based pan-CoV Fusion Inhibitor Potently Inhibits Infection of SARS-CoV-2 Omicron and Other Variants of Concern." DRAMP29164 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKW 45 EKL0 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.5830.073 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50>5 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.4420.037 mol/L),inhibition of cell-cell fusion(IC50=0.2770.029 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29165 NVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEY 36 EKL1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:##SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.6220.089 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50>5 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.7460.152 mol/L),inhibition of cell-cell fusion(IC50=0.2200.034 mol/L);inhibited authentic SARS-CoV-2 infection in Vero E6 cells(IC50=1.4070.189 mol/L);##inhibition of multiple HCoV Pseudovirus:SARS-CoV (IC50=6.7165.937 mol/L), MERS-CoV(IC50=4.0860.345 mol/L), HCoV-OC43(IC50=10.5303.778 mol/L), HCoV-NL63(IC50=3.7000.222 mol/L), SARSr-CoV-WIV1(IC50=30.2704.713 mol/L), and HCoV-Rs3367 (IC50=88.30024.600 mol/L),inhibition of authentic HCoV-OC43 infection in RD cells (IC50=20.2901.092 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29166 TFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYV 36 EKL2 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.5260.049 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50>5 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=4.7141.173 mol/L),inhibition of cell-cell fusion(IC50=1.2400.246 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29167 LDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKW 36 EKL3 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50>10 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50>5 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50>5 mol/L),inhibition of cell-cell fusion(IC50=2.1670.270 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29168 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKWGSGC 49 EKL0C No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.1220.012 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50=0.1470.055 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.1620.022 mol/L),inhibition of cell-cell fusion(IC50=0.0210.003 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29169 TFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVGSGC 40 EKL2C No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.1150.019 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50=0.0540.014 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.2000.020 mol/L),inhibition of cell-cell fusion(IC50=0.0220.001 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29170 LDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKWGSGC 40 EKL3C No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.1270.293 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50=1.1761.230 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.8920.069 mol/L),inhibition of cell-cell fusion(IC50=0.0450.004 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29171 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKWGSGK 49 EKL0P No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.0930.012 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50=0.6190.341 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.1760.019 mol/L),inhibition of cell-cell fusion(IC50=0.0830.009 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Palm None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29172 NVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYGSGK 40 EKL1P No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=0.1820.034 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50=0.8120.182 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.2310.022 mol/L),inhibition of cell-cell fusion(IC50=0.0640.004 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Palm None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29173 TFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVGSGK 40 EKL2P No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=1.1290.166 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50=0.9730.254 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=0.3040.051 mol/L),inhibition of cell-cell fusion(IC50=0.1830.028 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Palm None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29174 LDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKWGSGK 40 EKL3P No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs. "[Ref.34367893]Virus:SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cells(IC50=3.9870.682 mol/L),Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cells(IC50>5 mol/L),Inhibition of Pseudovirus(PsV) infection in Caco-2 cells(IC50=2.2140.371 mol/L),inhibition of cell-cell fusion(IC50=0.1930.021 mol/L)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Palm None L No cytotoxicity information found in the reference(s) presented liposomes 34367893 Acta Pharm Sin B. 2021 Aug 2. "Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q." A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. DRAMP29175 DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 "2019-nCoV-HR2P(SARS-CoV-2-S(1168-1203),SARS-HR2P)" Q5DIC5 Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Hemology Alpha helix Not found None Mechanism of action:2019-nCoV HR1 and HR2 regions are able to interact with each other to form 6-HB and suggest that 2019-nCoV-HR2P may inhibit 2019-nCoV fusion with and entry into the target cell. "[Ref.32047258]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in Huh-7 cells(IC50=0.18 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=0.98 ?M).##[Ref.30989115]SARS-CoV:ihibition of cell-cell fusion in Huh-7 cells(IC50=0.520.11 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=2.81 ?M);##MERS-CoV:ihibition of cell-cell fusion in Huh-7 cells(IC50>5 ?M);##HCoV-OC43:ihibition of cell-cell fusion in Huh-7 cells(IC50>5 ?M);##HCoV-229E:ihibition of cell-cell fusion in Huh-7 cells(IC50>5 ?M);##HCoV-NL63:ihibition of cell-cell fusion in Huh-7 cells(IC50>5 ?M);##CoV-WIV1:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=2.73 ?M);##CoV-Rs3367:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=3.05 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented liposomes 30989115##32047258 Sci Adv. 2019 Apr 10;5(4):eaav4580.##Cell Mol Immunol. 2020 Jul;17(7):765-767. "Xia S, Yan L, Xu W, Agrawal AS, Algaissi A, Tseng CK, Wang Q, Du L, Tan W, Wilson IA, Jiang S, Yang B, Lu L.##Xia S, Zhu Y, Liu M, Lan Q, Xu W, Wu Y, Ying T, Liu S, Shi Z, Jiang S, Lu L." A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.##Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein. DRAMP29176 NGAICWGPCPTAFRQIGNCGHFKVRCCKIR 30 MBD-4 (11-40)(P9) P82019 Belongs to the beta-defensin family. Defb4 Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found 6M56 Mechanism of action:Mechanistic studies show that positively charged P9 broadly inhibits viral replication by binding to different viruses and then inhibits virusChost endosomal acidification to prevent the endosomal release of pH-dependent viruses. [Ref.32843628]Virus:##SARS-CoV-2:Inhibition of infection in Vero E6 cells(IC50=2.4 ?g/ml);##SARS-CoV:Inhibition of infection in Vero E6 cells(IC50=6.2 ?g/ml);##MERS-CoV:Inhibition of infection in Vero E6 cells(IC50=8.8 ?g/ml);##Human rhinovirus (HRV):inhibition of infection in RD cells(IC50=34 ?g/ml);##Human parain?uenza virus 3:Inhibition of infection in LLC-MK2 cells(IC50>25 ?g/ml);##Human Influenza A Virus H1N1:Inhibition of infection In MDCK cells(IC50=1.6 ?g/ml);##Human Influenza A Virus H7N9:Inhibition of infection In MDCK cells(IC50=3.3 ?g/ml).##[Ref.26911565]Virus:Human Influenza A Virus H1N1(IC50=1.2 ?g/ml);Human Influenza A Virus H3N2(IC50=1.2 ?g/ml);Human Influenza A Virus H5N1(IC50=2.4 ?g/ml);Human Influenza A Virus H7N7(IC50=0.8 ?g/ml);Human Influenza A Virus H7N9(IC50=4.6 ?g/ml);MERS-CoV(IC50=4.8 ?g/ml);SARS-CoV(IC50=4.8 ?g/ml) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L [Ref.26911565]Xytotoxicity against Madin-Darby canine kidney cells(TC50=380 g/ml). Not found 26911565##32843628 Sci Rep. 2016 Feb 25;6:22008. ##Nat Commun. 2020 Aug 25;11(1):4252. "Zhao H, Zhou J, Zhang K, Chu H, Liu D, Poon VK, Chan CC, Leung HC, Fai N, Lin YP, Zhang AJ, Jin DY, Yuen KY, Zheng BJ.##Zhao H, To KKW, Sze KH, Yung TT, Bian M, Lam H, Yeung ML, Li C, Chu H, Yuen KY." A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. ##A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. DRAMP29177 NGAICWGPCPTAFRQIGNCGRFRVRCCRIR 30 "MBD-4 (11-40) (P9 [H21R,K23R,K28R], P9R)" P82019 Belongs to the beta-defensin family. Defb5 Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found 6M56 Mechanism of action:Mechanistic studies show that positively charged P9R broadly inhibits viral replication by binding to different viruses and then inhibits virusChost endosomal acidification to prevent the endosomal release of pH-dependent viruses. [Ref.32843628]Virus:##SARS-CoV-2:Inhibition of infection in Vero E6 cells(IC50=0.9 ?g/ml);##SARS-CoV:Inhibition of infection in Vero E6 cells(IC50=4.2 ?g/ml);##MERS-CoV:Inhibition of infection in Vero E6 cells(IC50=22 ?g/ml);##Human rhinovirus (HRV):inhibition of infection in RD cells(IC50=5.7 ?g/ml);##Human parain?uenza virus 3:Inhibition of infection in LLC-MK2 cells(IC50>25 ?g/ml);##Human Influenza A Virus H1N1:Inhibition of infection In MDCK cells(IC50=0.6 ?g/ml);##Human Influenza A Virus H7N9:Inhibition of infection In MDCK cells(IC50=0.9 ?g/ml). [Ref.32843628]P9R did not cause the hemolysis of Chicken red blood cells. Linear Free Free None L "[Ref.32843628]the CC50 of P9R was >300?g/ml for MDCK, VeroE6 and A549 cells." Not found 32843628 Nat Commun. 2020 Aug 25;11(1):4252. "Zhao H, To KKW, Sze KH, Yung TT, Bian M, Lam H, Yeung ML, Li C, Chu H, Yuen KY." A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. DRAMP29178 NGAICWGPCPTAFRQIGNCGRFRVRCCRIR 30 8P9R(branched P9R) No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:Have dual-antiviral mechanisms of cross-linking viruses to stop viral entry (mediated by TMPRSS2 for SARS-CoV-2) and of reducing endosomal acidification to inhibit viral entry through endocytic pathway. [Ref.33750821]Virus:SARS-CoV-2:inhibition of replication in high salt condition(IC50?=?0.3?g/ml) [Ref.33750821]no obvious hemolysis was observed when turkey red blood cells were treated at 200?g/ml. Branched Free Free None L [Ref.33750821]Vero-E6 cells:the cytotoxicity indicated that TC50 of 8P9R was higher than 200?g/ml. Not found 33750821 Nat Commun. 2021 Mar 9;12(1):1517. "Zhao H, To KKW, Lam H, Zhou X, Chan JF, Peng Z, Lee ACY, Cai J, Chan WM, Ip JD, Chan CC, Yeung ML, Zhang AJ, Chu AWH, Jiang S, Yuen KY." Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2. DRAMP29179 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 35 "IPB01(SARS-CoV-S (1151-1185),SR9, SARS-CoV-2-S (1169-1203))" "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Alpha helix Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=0.0220.005 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=33.7411.827 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M).##[Ref.17942557]Virus:SARS-CoV:Inhibition of virus entry in VERO-E6 cells(EC50=0.005 ?M).##[Ref.18442051]Virus:SARS-CoV: inhibition of PsV entry in Vero-E6 cells(EC50=0.34 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented liposomes 17942557##18442051##32376627 J Virol. 2008 Jan;82(1):588-92.##J Cell Biochem. 2008 Aug 15;104(6):2335-47.##J Virol. 2020 Jul 1;94(14):e00635-20. "Ujike M, Nishikawa H, Otaka A, Yamamoto N, Yamamoto N, Matsuoka M, Kodama E, Fujii N, Taguchi F. ##Chu LH, Chan SH, Tsai SN, Wang Y, Cheng CH, Wong KB, Waye MM, Ngai SM. ##Zhu Y, Yu D, Yan H, Chong H, He Y." "Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway.##Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors.##Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29180 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELK 36 IPB02(SARS-CoV-2-S (1169-1203)-K) "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Alpha helix Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=0.025 0.002 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=0.080.017 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC=0.251 0.118 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32376627 J Virol. 2020 Jul 1;94(14):e00635-20. "Zhu Y, Yu D, Yan H, Chong H, He Y." "Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29181 INASVVNIQKEIDRLNEVAKNLNESLIDLQELGK 34 IPB03(SARS-CoV-2-S (1172-1205)) "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Alpha helix Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=0.015 0.002 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=0.947 0.179 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC=1.315 0.463 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32376627 J Virol. 2020 Jul 1;94(14):e00635-20. "Zhu Y, Yu D, Yan H, Chong H, He Y." "Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29182 SVVNIQKEIDRLNEVAKNLNESLIDLQELGK 31 IPB04(SARS-CoV-2-S (1175-1205)) "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Alpha helix Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=0.033 0.013 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=0.218 0.063 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC=1.053 0.444 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32376627 J Virol. 2020 Jul 1;94(14):e00635-20. "Zhu Y, Yu D, Yan H, Chong H, He Y." "Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29183 IQKEIDRLNEVAKNLNESLIDLQELGK 27 IPB05(SARS-CoV-2-S (1179-1205)) "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50>5 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>25 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC>25 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32376627 J Virol. 2020 Jul 1;94(14):e00635-20. "Zhu Y, Yu D, Yan H, Chong H, He Y." "Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29184 IDRLNEVAKNLNESLIDLQELGK 23 IPB06(SARS-CoV-2-S (1183-1205)) "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50>5 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>25 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC>25 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32376627 J Virol. 2020 Jul 1;94(14):e00635-20. "Zhu Y, Yu D, Yan H, Chong H, He Y." "Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29185 IQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 33 IPB07(SARS-CoV-2-S (1179-1211)) "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Alpha helix Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=0.017 0.001 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=0.993 0.08 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC=1.037 0.836 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32376627 J Virol. 2020 Jul 1;94(14):e00635-20. "Zhu Y, Yu D, Yan H, Chong H, He Y." "Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29186 ISGINASVVNIQKEIDRLNEVAKNLNESLIK 31 IPB08(SARS-CoV-2-S (1169-1198)-K) "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=4.66 1.565 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=1.738 0.898 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC=1.13 0.472 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32376627 J Virol. 2020 Jul 1;94(14):e00635-20. "Zhu Y, Yu D, Yan H, Chong H, He Y." "Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29187 SVVNIQKEIDRLNEVAKNLNESLIK 25 IPB09(SARS-CoV-2-S (1175-1198)-K) "P59594,P0DTC2" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None "Mechanism of action:The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently." "[Ref.32376627]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50>5 ?M),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>25 ?M);##SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC>25 ?M);##Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 32376627 J Virol. 2020 Jul 1;94(14):e00635-20. "Zhu Y, Yu D, Yan H, Chong H, He Y." "Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity." DRAMP29188 DEDLEELERLYRKAEEVAKEAKDASRRGDDERAKEQMERAMRLFDQVFELAQELQEKQTDGNRQKATHLDKAVKEAADELYQRVR 85 AHB1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide is a high-affinity protein minibinder to the SARS-CoV-2 spike receptor binding domain (RBD) that compete with ACE2 binding. [Ref.32907861]Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells(IC50=35 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 32907861 Science. 2020 Oct 23;370(6515):426-431. "Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. " De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. DRAMP29189 ELEEQVMHVLDQVSELAHELLHKLTGEELERAAYFNWWATEMMLELIKSDDEREIREIEEEARRILEHLEELARK 75 AHB2 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide is a high-affinity protein minibinder to the SARS-CoV-2 spike receptor binding domain (RBD) that compete with ACE2 binding. [Ref.32907861]Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells(IC50=15.5 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 32907861 Science. 2020 Oct 23;370(6515):426-431. "Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. " De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. DRAMP29190 DKEWILQKIYEIMRLLDELGHAEASMRVSDLIYEFMKKGDERLLEEAERLLEEVER 56 LCB1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide is a high-affinity protein minibinder to the SARS-CoV-2 spike receptor binding domain (RBD) that compete with ACE2 binding. [Ref.32907861]Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells(IC50=23.54 pM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 32907861 Science. 2020 Oct 23;370(6515):426-431. "Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. " De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. DRAMP29191 NDDELHMLMTDLVYEALHFAKDEEIKKRVFQLFELADKAYKNNDRQKLEKVVEELKELLERLLS 64 LCB3 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide is a high-affinity protein minibinder to the SARS-CoV-2 spike receptor binding domain (RBD) that compete with ACE2 binding. [Ref.32907861]Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells(IC50=48.1 pM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 32907861 Science. 2020 Oct 23;370(6515):426-431. "Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. " De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. DRAMP29192 TFLDKFNHEAEDLFYQ 16 ACE2 (27-42)(SAP1) Q9BYF1 Belongs to the peptidase M2 family. ACE2 Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors. [Ref.33356169]Virus:##SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50=2.390.20 mM);Inhibition of infection in 293T/ACE2/GFP cells(IC50=3 mM);##SARS-CoV:Inhibition of infection in 293T/ACE2 cells(80% inhibition at 3 mM);##Vesicular Stomatitis Virus (VSV):No nhibition of infection in 293T/ACE2 cells up to 3 mM;##HCoV-NL63:Inhibition of cytopathic effect in LLC-MK2 cells(30% Inhibition at 3 mM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 33356169 Bioconjug Chem. 2021 Jan 20;32(1):215-223. "Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A." Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. DRAMP29193 EDLFYQSSL 9 ACE2 (37-45)(SAP2) Q9BYF1 Belongs to the peptidase M3 family. ACE2 Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors. [Ref.33356169]Virus:##SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50=3.720.37 mM) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 33356169 Bioconjug Chem. 2021 Jan 20;32(1):215-223. "Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A." Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. DRAMP29194 LAQMYPL 7 ACE2 (79-85)(SAP3) Q9BYF1 Belongs to the peptidase M4 family. ACE2 Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors. [Ref.33356169]Virus:##SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50>7.5 mM) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 33356169 Bioconjug Chem. 2021 Jan 20;32(1):215-223. "Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A." Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. DRAMP29195 GKGDFRIL 8 ACE2 (352-359)(SAP4) Q9BYF1 Belongs to the peptidase M5 family. ACE2 Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors. [Ref.33356169]Virus:##SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50>7.5 mM) No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 33356169 Bioconjug Chem. 2021 Jan 20;32(1):215-223. "Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A." Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. DRAMP29196 QAKTFLDKFNHEA 13 ACE2 (24-36)(SAP5) Q9BYF1 Belongs to the peptidase M6 family. ACE2 Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors. [Ref.33356169]Virus:##SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50>7.5 mM);No nhibition of infection in 293T/ACE2/GFP cells up to 3 mM;##SARS-CoV:Inhibition of infection in 293T/ACE2 cells(30% inhibition at 3 mM);##Vesicular Stomatitis Virus (VSV):No nhibition of infection in 293T/ACE2 cells up to 3 mM. No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 33356169 Bioconjug Chem. 2021 Jan 20;32(1):215-223. "Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A." Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. DRAMP29197 EDLFYQ 6 ACE2 (37-42)(SAP6) Q9BYF1 Belongs to the peptidase M4 family. ACE2 Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors. [Ref.33356169]Virus:##SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50=1.90.14 mM);Inhibition of infection in 293T/ACE2/GFP cells(IC50=3 mM);##SARS-CoV:Inhibition of infection in 293T/ACE2 cells(85% inhibition at 3 mM);##Vesicular Stomatitis Virus (VSV):No nhibition of infection in 293T/ACE2 cells up to 3 mM;##HCoV-NL63:Inhibition of cytopathic effect in LLC-MK2 cells(30% Inhibition at 3 mM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 33356169 Bioconjug Chem. 2021 Jan 20;32(1):215-223. "Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A." Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. DRAMP29198 DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGSGSGC 42 SARS-CoV-2-S(1168C1203)-GSGSGC P0DTC2 Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:The lipopeptide is derived from the C-terminal heptad repeat (HRC) domain of SARS-CoV-2 S that potently inhibits infection by SARS-CoV-2. "[Ref.33082259]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T cells(IC50=108 nM,IC90=9857 nM),inhibition of infection in Vero E6 cells(IC50~ 6 nM);##SARS-CoV-2_D614G:ihibition of cell-cell fusion in 293T cells(IC50=84 nM,IC90=9650 nM);##SARS-CoV-2_S943P:ihibition of cell-cell fusion in 293T cells(IC50=64 nM,IC90=7542 nM);##SARS-CoV-2_S247R:ihibition of cell-cell fusion in 293T cells(IC50=97 nM,IC90=7859 nM);##MERS-CoV:ihibition of cell-cell fusion in 293T cells(IC50=3510 nM,IC90>1000 nM),inhibition of infection in Vero E6 cells(IC50~ 3 nM);##SARS-CoV-1:ihibition of cell-cell fusion in 293T cells(IC50=75 nM,IC90=436 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L "[Ref.33082259]Human embryonic kidney HEK293T cells:18% Cytotoxicity at 10 ?M;Vero E6 cells:12% Cytotoxicity at 1 ?M,30% Cytotoxicity at 10 ?M;Human airway epithelial cells:25% Cytotoxicity at 1 ?M." liposomes 33082259##33597220 mBio. 2020 Oct 20;11(5):e01935-20.##Science. 2021 Mar 26;371(6536):1379-1382. "Outlaw VK, Bovier FT, Mears MC, Cajimat MN, Zhu Y, Lin MJ, Addetia A, Lieberman NAP, Peddu V, Xie X, Shi PY, Greninger AL, Gellman SH, Bente DA, Moscona A, Porotto M.##de Vries RD, Schmitz KS, Bovier FT, Predella C, Khao J, Noack D, Haagmans BL, Herfst S, Stearns KN, Drew-Bear J, Biswas S, Rockx B, McGill G, Dorrello NV, Gellman SH, Alabi CA, de Swart RL, Moscona A, Porotto M." Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain.##Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets. DRAMP29199 SLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKELGSGSGC 42 MERS-CoV-HR2P-GSGSGC "R9UQ53,K9N5Q8" Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:The lipopeptide is derived from the C-terminal heptad repeat (HRC) domain of SARS-CoV-2 S that potently inhibits infection by SARS-CoV-2. "[Ref.33082259]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T cells(IC50>650 nM,IC90>1000 nM),inhibition of infection in Vero E6 cells(IC50~ 36 nM);##SARS-CoV-2_D614G:ihibition of cell-cell fusion in 293T cells(IC50=1000 nM,IC90>1000 nM);##SARS-CoV-2_S943P:ihibition of cell-cell fusion in 293T cells(IC50>1000,IC90>1000 nM);##SARS-CoV-2_S247R:ihibition of cell-cell fusion in 293T cells(IC50>700 nM,IC90>1000 nM);##MERS-CoV:ihibition of cell-cell fusion in 293T cells(IC50=417180 nM,IC90>1000 nM),inhibition of infection in Vero E6 cells(IC50~ 4 nM);##SARS-CoV-1:ihibition of cell-cell fusion in 293T cells(IC50=4034 nM,IC90>700 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L [Ref.33082259]Human embryonic kidney HEK293T cells:<10% Cytotoxicity at 10 ?M;Vero E6 cells:12% Cytotoxicity at 10 ?M. liposomes 33082259 mBio. 2020 Oct 20;11(5):e01935-20. "Outlaw VK, Bovier FT, Mears MC, Cajimat MN, Zhu Y, Lin MJ, Addetia A, Lieberman NAP, Peddu V, Xie X, Shi PY, Greninger AL, Gellman SH, Bente DA, Moscona A, Porotto M." Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain. DRAMP29200 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSGC 42 EK1-GSGSGC Q8BB25 Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Hemology Not found Not found None Mechanism of action:The lipopeptide is derived from the C-terminal heptad repeat (HRC) domain of SARS-CoV-2 S that potently inhibits infection by SARS-CoV-2. "[Ref.33082259]Virus:##SARS-CoV-2:ihibition of cell-cell fusion in 293T cells(IC50=29360 nM,IC90>900 nM),inhibition of infection in Vero E6 cells(IC50~ 41 nM);##SARS-CoV-2_D614G:ihibition of cell-cell fusion in 293T cells(IC50=261136 nM,IC90=892100 nM);##SARS-CoV-2_S943P:ihibition of cell-cell fusion in 293T cells(IC50=286104 nM,IC90>1000 nM);##SARS-CoV-2_S247R:ihibition of cell-cell fusion in 293T cells(IC50=194107 nM,IC90=89377 nM);##MERS-CoV:ihibition of cell-cell fusion in 293T cells(IC50>1000 nM,IC90>1000 nM),inhibition of infection in Vero E6 cells(IC50~ 2 nM);##SARS-CoV-1:ihibition of cell-cell fusion in 293T cells(IC50=365 nM,IC90>1000 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L [Ref.33082259]Human embryonic kidney HEK293T cells:<5% Cytotoxicity at 10 ?M;Vero E6 cells:18% Cytotoxicity at 10 ?M. liposomes 33082259 mBio. 2020 Oct 20;11(5):e01935-20. "Outlaw VK, Bovier FT, Mears MC, Cajimat MN, Zhu Y, Lin MJ, Addetia A, Lieberman NAP, Peddu V, Xie X, Shi PY, Greninger AL, Gellman SH, Bente DA, Moscona A, Porotto M." Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain. DRAMP29201 ANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQ 42 SARS-CoV-2 HR1P P0DTC2 Belongs to the betacoronaviruses spike protein family. S Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Protein level Not found Not found None Mechanism of action:The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection. "[Ref.32047258]Virus:SARS-CoV-2(No inhibition of cell-cell fusion up to 40 ?M in Huh-7 cells,No inhibition of infection up to 40 ?M in 293T/ACE2 cells)" No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 32047258 Cell Mol Immunol. 2020 Jul;17(7):765-767. "Xia S, Zhu Y, Liu M, Lan Q, Xu W, Wu Y, Ying T, Liu S, Shi Z, Jiang S, Lu L." Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein. DRAMP29202 PHSCN 5 ATN-161 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide inhibits the spike protein interaction with 51 integrin and the interaction between 51 integrin and ACE2. [Ref.33102950]Virus:SARS-CoV-2:inhibition of replication In VeroE6 cells(IC50=3.16 ?M). No hemolysis information or data found in the reference(s) presented in this entry Linear Acylation Amidation None L No cytotoxicity information found in the reference(s) presented Not found 33102950 JACC Basic Transl Sci. 2021 Jan;6(1):1-8. "Beddingfield BJ, Iwanaga N, Chapagain PP, Zheng W, Roy CJ, Hu TY, Kolls JK, Bix GJ." "The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection." DRAMP29203 RVKR 4 CMK No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "Mechanism of action:CMK blocks virus entry, but it further suppresses cleavage of spikes and the syncytium." "[Ref.33007239]Virus:SARS-CoV-2:inhibition of virus production in Vero E6 cells(IC50=0.057 ?M).##[Ref.31683742]Virus:Zika virus (ZIKV):inhibition of virus release in Vero cells(IC50=18.59 ?M);Japanese encephalitis virus (JEV):inhibition of virus release in BHK-21 cells(IC50=19.91 ?M).##[Ref.23617302]Virus:Hepatitis B virus (HBV):Inhibition of HBeAg secretion in HepG2.2.15 cells(2611% inhibition at 20 ?M,2113% Inhibition at 100 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Linear Decanoyl(C10) chloromethylketone(CMK) None L [Ref.31683742]Vero cells:CC50=712.9 ?M.[Ref.33007239]Vero E6 cells:IC50=318.2 ?M. Not found 23617302##31683742##33007239 Liver Int. 2013 Sep;33(8):1230-8. ##Viruses. 2019 Oct 31;11(11):1011.##Cell Rep. 2020 Oct 13;33(2):108254. "Pang YJ, Tan XJ, Li DM, Zheng ZH, Lei RX, Peng XM.##Imran M, Saleemi MK, Chen Z, Wang X, Zhou D, Li Y, Zhao Z, Zheng B, Li Q, Cao S, Ye J.##Cheng YW, Chao TL, Li CL, Chiu MF, Kao HC, Wang SH, Pang YH, Lin CH, Tsai YM, Lee WH, Tao MH, Ho TC, Wu PY, Jang LT, Chen PJ, Chang SY, Yeh SH." Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus.##Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage.##Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. DRAMP29204 LQTALYALMEEIHIAALEKTWTALRHQYT 29 Covid3 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acts as an inhibitor of the RBDCACE2 interaction [Ref.34624194]Virus:##SARS-CoV-2:inhibition of infection in Vero cells(IC50=6.56 2.14 M);##SARS-CoV-2 variants B.1.1.7:inhibition of infection in Vero cells(IC50=33.40 10.75 M);##SARS-CoV-2 variants B.1.351:inhibition of infection in Vero cells(IC50=11.13 3.82 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Acylation Amidation None D No cytotoxicity information found in the reference(s) presented Not found 34624194 J Med Chem. 2021 Oct 28;64(20):14955-14967. "Valiente PA, Wen H, Nim S, Lee J, Kim HJ, Kim J, Perez-Riba A, Paudel YP, Hwang I, Kim KD, Kim S, Kim PM. " Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2. DRAMP29205 RFDGKGLGIYQYMEEIEHAASRFAYFFYQHLA 32 Covid_extented_1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The peptide acts as an inhibitor of the RBDCACE2 interaction [Ref.34624194]Virus:##SARS-CoV-2:inhibition of infection in Vero cells(IC50=5.76 1.65 M);##SARS-CoV-2 variants B.1.1.7:inhibition of infection in Vero cells(IC50=5.57 4.04 M);##SARS-CoV-2 variants B.1.351:inhibition of infection in Vero cells(IC50=7.37 1.80 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Acylation Amidation None D No cytotoxicity information found in the reference(s) presented Not found 34624194 J Med Chem. 2021 Oct 28;64(20):14955-14967. "Valiente PA, Wen H, Nim S, Lee J, Kim HJ, Kim J, Perez-Riba A, Paudel YP, Hwang I, Kim KD, Kim S, Kim PM. " Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2. DRAMP29206 SALEEQYKTFLDKFLHELEDLLYQLALAL 29 P7 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "Mechanism of action:The peptide was designed mimicking the N-terminal helix of hACE2 protein,which could prevent the SARS-CoV-2 from infecting human cells, blocking the interaction between hACE2 and the virus spike protein." [Ref.33580154]Virus:SARS-CoV-2:54% inhibition of replication in Vero-E6 cells at 10?M;inhibition of replication in Calu-3 cells(IC50>1 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L No cytotoxicity information found in the reference(s) presented Not found 33580154 Commun Biol. 2021 Feb 12;4(1):197. "Karoyan P, Vieillard V, Gmez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O." Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. DRAMP29207 SALEEQLKTFLDKFMHELEDLLYQLAL 27 P8 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Alpha helix Not found None "Mechanism of action:The peptide was designed mimicking the N-terminal helix of hACE2 protein,which could prevent the SARS-CoV-2 from infecting human cells, blocking the interaction between hACE2 and the virus spike protein." [Ref.33580154]Virus:SARS-CoV-2:91% inhibition of replication in Vero-E6 cells at 10?M;inhibition of replication in Calu-3 cells(IC50=46 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L [Ref.33580154]The peptide proved to be devoid of cell toxicity on Vero-E6 and Calu-3 cells. Not found 33580154 Commun Biol. 2021 Feb 12;4(1):197. "Karoyan P, Vieillard V, Gmez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O." Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. DRAMP29208 SALEEQYKTFLDKFMHELEDLLYQLSL 27 P9 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "Mechanism of action:The peptide was designed mimicking the N-terminal helix of hACE2 protein,which could prevent the SARS-CoV-2 from infecting human cells, blocking the interaction between hACE2 and the virus spike protein." [Ref.33580154]Virus:SARS-CoV-2:93% inhibition of replication in Vero-E6 cells at 10?M;inhibition of replication in Calu-3 cells(IC50=53 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L [Ref.33580154]The peptide proved to be devoid of cell toxicity on Vero-E6 and Calu-3 cells. Not found 33580154 Commun Biol. 2021 Feb 12;4(1):197. "Karoyan P, Vieillard V, Gmez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O." Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. DRAMP29209 SALEEQYKTFLDKFMHELEDLLYQLAL 27 P10 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "Mechanism of action:The peptide was designed mimicking the N-terminal helix of hACE2 protein,which could prevent the SARS-CoV-2 from infecting human cells, blocking the interaction between hACE2 and the virus spike protein." [Ref.33580154]Virus:SARS-CoV-2:95% inhibition of replication in Vero-E6 cells at 10?M;inhibition of replication in Calu-3 cells(IC50=42 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Amidation None L [Ref.33580154]The peptide proved to be devoid of cell toxicity on Vero-E6 and Calu-3 cells. Not found 33580154 Commun Biol. 2021 Feb 12;4(1):197. "Karoyan P, Vieillard V, Gmez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O." Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection. DRAMP29210 RGAHIKGRWKSRCHRF 16 FBP No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None The fusion-inhibition peptide FBP could broadly inhibit influenza virus and SARS-CoV-2 by interfering the viral fusion by the endocytic pathway and showed potently antiviral activity against the influenza virus in mice and SARS-CoV-2 variants in hamsters. "[Ref.35259078]Virus:A(H1N1)(IC50?=?3.9 g/ml);A(H3N2)(IC50?=?1.6 g/ml);FluB (IC50?=?7.1 g/ml);SARS-CoV-2 (HKU001a):inhibition of infection in Vero-E6 cells(IC50=2.9 g/ml);SARS-CoV-2 (B.1.1.63, D614G):inhibition of infection in Vero-E6 cells(IC50=3.0 g/ml);SARS-CoV-2(Delta):inhibition of infection in Vera-E6 cells(IC50=3.9 g/ml)." [Ref.35259078]No significant hemolysis against Turkey red blood cells (RBC). Linear Free Free None L [Ref.35259078]No significant cytotoxicity was detected in MDCK(Madin Darby canine kidney) cells at 1 mg/ml(TC50?>?1?mg/ml). liposomes 35259078 Emerg Microbes Infect. 2022 Dec;11(1):926-937. "Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY." "Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants." DRAMP29211 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1P4HC No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "The peptide targets two different sites when mediating virusCcell fusion,which are blocking viral 6-HB formation and reducing the membrane cholesterol level." [Ref.34769299]Virus:##SARS-CoV-2:inhibition of Pseudoviruse infection in Caco2 cells(IC50=0.8 M);##SARS-CoV-2 B.1.1.7 (Alpha):inhibition of Pseudoviruse infection in Caco2 cells(IC50=2.28 M);##SARS-CoV-2 B.1.351 (Beta):inhibition of Pseudoviruse infection in Caco2 cells(IC50=0.62 M);##SARS-CoV-2 P.1 (Gamma):inhibition of Pseudoviruse infection in Caco2 cells(IC50=0.48 M);##SARS-CoV-2 B.1.617.2 (Delta):inhibition of Pseudoviruse infection in Caco2 cells(IC50=0.11 M);##HCoV-229E(Authentic):inhibition of infection in Caco2 cells(IC50=0.48 M);##HCoV-OC43(Authentic):inhibition of infection in Caco2 cells(IC50=0.41 M);##SARS-CoV:inhibition of Pseudoviruse infection in Caco2 cells(IC50=0.35 M);##MERS-CoV:inhibition of Pseudoviruse infection in Caco2 cells(IC50=0.10 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG4-25-HC None L [Ref.34769299]no apparent cytotoxicity against Caco-2 cells at concentrations of up to 20 M. liposomes 34769299 Int J Mol Sci. 2021 Nov 1;22(21):11869. "Lan Q, Wang C, Zhou J, Wang L, Jiao F, Zhang Y, Cai Y, Lu L, Xia S, Jiang S. " "25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses." DRAMP29212 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1P8HC No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "The peptide targets two different sites when mediating virusCcell fusion,which are blocking viral 6-HB formation and reducing the membrane cholesterol level." [Ref.34769299]Virus:SARS-CoV-2:inhibition of Pseudoviruse infection in Caco2 cells(IC50=3.7 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-25-HC None L [Ref.34769299]no apparent cytotoxicity against Caco-2 cells at concentrations of up to 20 M. liposomes 34769299 Int J Mol Sci. 2021 Nov 1;22(21):11869. "Lan Q, Wang C, Zhou J, Wang L, Jiao F, Zhang Y, Cai Y, Lu L, Xia S, Jiang S. " "25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses." DRAMP29213 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1P12HC No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "The peptide targets two different sites when mediating virusCcell fusion,which are blocking viral 6-HB formation and reducing the membrane cholesterol level." [Ref.34769299]Virus:SARS-CoV-2:inhibition of Pseudoviruse infection in Caco2 cells(IC50=5.2 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG12-25-HC None L [Ref.34769299]no apparent cytotoxicity against Caco-2 cells at concentrations of up to 20 M. liposomes 34769299 Int J Mol Sci. 2021 Nov 1;22(21):11869. "Lan Q, Wang C, Zhou J, Wang L, Jiao F, Zhang Y, Cai Y, Lu L, Xia S, Jiang S. " "25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses." DRAMP29214 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG 41 EK1P24HC No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "The peptide targets two different sites when mediating virusCcell fusion,which are blocking viral 6-HB formation and reducing the membrane cholesterol level." [Ref.34769299]Virus:SARS-CoV-2:inhibition of Pseudoviruse infection in Caco2 cells(IC50=10.3 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG24-25-HC None L [Ref.34769299]no apparent cytotoxicity against Caco-2 cells at concentrations of up to 20 M. liposomes 34769299 Int J Mol Sci. 2021 Nov 1;22(21):11869. "Lan Q, Wang C, Zhou J, Wang L, Jiao F, Zhang Y, Cai Y, Lu L, Xia S, Jiang S. " "25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses." DRAMP29215 SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 37 IBP20 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 48% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None "Mechanism of action:Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived." [Ref.34057039]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=1.36 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=50.52 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=33.85 nM);##SARS-CoV-2 D614G:inhibition of pseudovirus infections in Huh-7 cells(IC50=103.17 nM);##SARS-CoV-2 N501Y:inhibition of pseudovirus infections in Huh-7 cells(IC50=128.87 nM);##SARS-CoV-2 H69-V70:inhibition of pseudovirus infections in Huh-7 cells(IC50=111.41 nM);##SARS-CoV-2 E484K:inhibition of pseudovirus infections in Huh-7 cells(IC50=79.09 nM);##SARS-CoV-2 B.1.1.7:inhibition of pseudovirus infections in Huh-7 cells(IC50=88.49 nM);##SARS-CoV-2 B.1.351:inhibition of pseudovirus infections in Huh-7 cells(IC50=92.16 nM);##SARS-CoV:inhibition of pseudovirus infections in Huh-7 cells(IC50=73.86 nM);##MERS-CoV:inhibition of pseudovirus infections in Huh-7 cells(IC50=228.4 nM);##HCoV-NL63:inhibition of pseudovirus infections in Huh-7 cells(IC50=817.21 nM);##HCoV-229E:inhibition of pseudovirus infections in Huh-7 cells(IC50=471.54 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol(cholesterol) None L No cytotoxicity information found in the reference(s) presented Not found 34057039 Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. "Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y." Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. DRAMP29216 SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 37 IBP21 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "Mechanism of action:Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived." [Ref.34057039]Virus:SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=7.5 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=191.4 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=126.65 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free C16(palmitic acid) None L No cytotoxicity information found in the reference(s) presented Not found 34057039 Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. "Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y." Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. DRAMP29217 SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 37 IBP22 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "Mechanism of action:Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived." [Ref.34057039]Virus:SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=6.23 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=179.95 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=86.33 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free C18(stearic acid) None L No cytotoxicity information found in the reference(s) presented Not found 34057039 Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. "Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y." Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. DRAMP29218 SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 37 IBP23 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "Mechanism of action:Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived." [Ref.34057039]Virus:SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=39.07 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=1236.38 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=507.32 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Toc(tocophenol) None L No cytotoxicity information found in the reference(s) presented Not found 34057039 Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. "Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y." Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. DRAMP29219 SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 37 IBP24 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 16% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None "Mechanism of action:Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived." [Ref.34057039]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.33 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=3.77 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=2.89 nM);inhibition of live SARS-CoV-2 infection in Vero cells(IC50=8.97 nM);##SARS-CoV-2 D614G:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.29 nM);##SARS-CoV-2 N501Y:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.5 nM);##SARS-CoV-2 H69-V70:inhibition of pseudovirus infections in Huh-7 cells(IC50=7.42 nM);##SARS-CoV-2 E484K:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.97 nM);##SARS-CoV-2 B.1.1.7:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.22 nM);##SARS-CoV-2 B.1.351:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.06 nM);##SARS-CoV:inhibition of pseudovirus infections in Huh-7 cells(IC50=21.64 nM);##MERS-CoV:inhibition of pseudovirus infections in Huh-7 cells(IC50=69.9 nM);##HCoV-NL63:inhibition of pseudovirus infections in Huh-7 cells(IC50=375.56 nM);##HCoV-229E:inhibition of pseudovirus infections in Huh-7 cells(IC50=421.48 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG4-K(Chol) None L [Ref.34057039]Huh-7 cells:CC50=6.6 M;Vero-E6 cells:CC50=13.67 M. Not found 34057039 Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. "Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y." Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. DRAMP29220 SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 37 IBP25 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 18% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None "Mechanism of action:Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived." "[Ref.34057039]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.29 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=2.13 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=1.43 nM),inhibition of live SARS-CoV-2 infection in Vero cells(IC50=25.71 nM);##SARS-CoV-2 D614G:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.8 nM);##SARS-CoV-2 N501Y:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.52 nM);##SARS-CoV-2 H69-V70:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.56 nM);##SARS-CoV-2 E484K:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.71 nM);##SARS-CoV-2 B.1.1.7:inhibition of pseudovirus infections in Huh-7 cells(IC50=5.87 nM);##SARS-CoV-2 B.1.351:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.76 nM);##SARS-CoV:inhibition of pseudovirus infections in Huh-7 cells(IC50=17.69 nM);##MERS-CoV:inhibition of pseudovirus infections in Huh-7 cells(IC50=48.5 nM);##HCoV-NL63:inhibition of pseudovirus infections in Huh-7 cells(IC50=353.22 nM);##HCoV-229E:inhibition of pseudovirus infections in Huh-7 cells(IC50=336.14 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG5-K(Chol) None L [Ref.34057039]Huh-7 cells:CC50=3.54 M;Vero-E6 cells:CC50=6.95 M. Not found 34057039 Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. "Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y." Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. DRAMP29221 SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 37 IBP26 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None "Mechanism of action:Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived." [Ref.34057039]Virus:SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.26 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=3.05 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=1.82 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG6-K(Chol) None L No cytotoxicity information found in the reference(s) presented Not found 34057039 Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. "Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y." Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. DRAMP29222 SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 37 IBP27 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 12% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None "Mechanism of action:Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived." "[Ref.34057039]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.32 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=2.77 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=1.54 nM),inhibition of live SARS-CoV-2 infection in Vero cells(IC50=29.85 nM);##SARS-CoV-2 D614G:inhibition of pseudovirus infections in Huh-7 cells(IC50=6.75 nM);##SARS-CoV-2 N501Y:inhibition of pseudovirus infections in Huh-7 cells(IC50=7.87 nM);##SARS-CoV-2 H69-V70:inhibition of pseudovirus infections in Huh-7 cells(IC50=7.56 nM);##SARS-CoV-2 E484K:inhibition of pseudovirus infections in Huh-7 cells(IC50=7.55 nM);##SARS-CoV-2 B.1.1.7:inhibition of pseudovirus infections in Huh-7 cells(IC50=7.18 nM);##SARS-CoV-2 B.1.351:inhibition of pseudovirus infections in Huh-7 cells(IC50=8.25 nM);##SARS-CoV:inhibition of pseudovirus infections in Huh-7 cells(IC50=24.95 nM);##MERS-CoV:inhibition of pseudovirus infections in Huh-7 cells(IC50=60.08 nM);##HCoV-NL63:inhibition of pseudovirus infections in Huh-7 cells(IC50=179.53 nM);##HCoV-229E:inhibition of pseudovirus infections in Huh-7 cells(IC50=231.18 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L [Ref.34057039]Huh-7 cells:CC50=4.04 M;Vero-E6 cells:CC50=5.05 M. Not found 34057039 Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. "Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y." Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. DRAMP29223 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 35 IBP02V1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 0% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=1.10.1 nM);inhibition of SARS-CoV-2 pseudovirus infection in 293T/ACE2 cells(IC50=17.8 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=14.3 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=0.60.1 nM);inhibition of pseudovirus infection in 293T/ACE2 cells(IC50=50 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=21.5 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=33.63.5 nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=66.97.6 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=62.517.2 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=203.98.8 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L [Ref.34344868]No significant cytotoxicity in both 293T/ACE2 and Huh-7 cells at a concentration of 10?M. liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29224 DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 IBP02V2 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 22% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.60.03 nM);inhibition of SARS-CoV-2 pseudovirus infection in 293T/ACE2 cells(IC50=20.1 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=18.1 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=0.40.04 nM);inhibition of pseudovirus infection in 293T/ACE2 cells(IC50=19.3 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=20.8 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=56.59.4nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=55.32.8 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=67.58 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=535.744.6 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L [Ref.34344868]No significant cytotoxicity in both 293T/ACE2 and Huh-7 cells at a concentration of 10?M. liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29225 EISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 IBP02V3 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 48% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.40.02 nM);inhibition of SARS-CoV-2 pseudovirus infection in 293T/ACE2 cells(IC50=14.1 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=17.5 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=0.20.02 nM);inhibition of pseudovirus infection in 293T/ACE2 cells(IC50=40.2 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=14.4 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=485.8 nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=38.56.2 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=75.89.9 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=545.70.9 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L [Ref.34344868]No significant cytotoxicity in both 293T/ACE2 and Huh-7 cells at a concentration of 10?M. liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29226 ELSGINASVVNLQKEIDRLNEVAKNLNESLIDLQEL 36 IBP02V4 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 59% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.30.02 nM);inhibition of SARS-CoV-2 pseudovirus infection in 293T/ACE2 cells(IC50=18.6 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=15.2 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=0.10.02 nM);inhibition of pseudovirus infection in 293T/ACE2 cells(IC50=29.2 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=26.3 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=631.7 nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=22.42.2 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=66.33.1 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=50224.2 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L [Ref.34344868]No significant cytotoxicity in both 293T/ACE2 and Huh-7 cells at a concentration of 10?M. liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29227 SLTQINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 IBP02V5 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 16% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=2.10.5 nM);inhibition of SARS-CoV-2 pseudovirus infection in 293T/ACE2 cells(IC50=21 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=23.5 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=1.30.1 nM);inhibition of pseudovirus infection in 293T/ACE2 cells(IC50=98.8 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=27.5 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=65.913.2 nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=68.49.7 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=70.88.7 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=1128.4148.6 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L [Ref.34344868]No significant cytotoxicity in both 293T/ACE2 and Huh-7 cells at a concentration of 10?M. liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29228 SLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKEL 36 MERS-LP No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 8% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=102.97.2 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=5046905.2 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=79.19.8 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50>25000 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50>25000 nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=82.98.6 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50>25000 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50>25000 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L No cytotoxicity information found in the reference(s) presented liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29229 SLDYINVTFLDLQDEMNRLQEAIKVLNQSYINLKDI 36 OC43-LP No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 22% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=4.11 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=82.822.1 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=2.40.2 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=97.55.9 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=250.439.7 nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=5.20.5 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=416.5227.5 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=2008.8697.9 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L No cytotoxicity information found in the reference(s) presented liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29230 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELK 37 EK1V1 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 39% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37 C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=273.54.1 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=2672.1384.5 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=214.520.2 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=1790.8363.2 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=4370.3719.7 nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=499.8163.3 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=487.241.3 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=1255.6453.3 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Chol None L No cytotoxicity information found in the reference(s) presented liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29231 SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL 36 EK1V2 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found 68% -helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 M and incubated at 37C Not found None The peptide is a fusion inhibitor against SARS-CoV-2. [Ref.34344868]Virus:##SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.90.2 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=87.28.3 nM);##SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=0.50.2 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=106.55.4 nM);##SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=2525.6 nM);##MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=1.10.3 nM);##HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=59.413.1 nM);##HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=503.320.9 nM). No hemolysis information or data found in the reference(s) presented in this entry Linear Free PEG8-K(Chol) None L No cytotoxicity information found in the reference(s) presented liposomes 34344868 Signal Transduct Target Ther. 2021 Aug 3;6(1):294. "Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y." SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. DRAMP29232 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 35 P3 No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Comment: No comments found on DRAMP database [Ref.32482145]Virus:HCoV-19:inhibition of HCoV-19 S mediated cellCcell fusion(EC50=0.72 M);neutralizing activities against pseudotype HCoV-19 virus(EC50=0.32 M);inhibition of authentic HCoV-19 virus infection in Vero E6 cells(EC50=0.58 M). No hemolysis information or data found in the reference(s) presented in this entry Linear Free Free None L No cytotoxicity information found in the reference(s) presented Not found 32482145 Emerg Microbes Infect. 2020 Dec;9(1):1238-1241. "Sun H, Li Y, Liu P, Qiao C, Wang X, Wu L, Liu K, Hu Y, Su C, Tan S, Zou S, Wu G, Yan J, Gao GF, Qi J, Wang Q. " Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry. DRAMP29233 XxXVXAaXXXX 11 "Alisporivir, Debio-025" No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Comment: No comments found on DRAMP database "[Ref.32376613]Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells(EC50=0.460.04 ?M,E90=3.101.40 M).##[Ref.32568027]Virus:##SARS-CoV-2:Inhibition of infection in Vero E6 cells(EC50=4.91.3 ?M);##SARS-CoV:Inhibition of infection in Vero E6 cells(EC50=4.31.0 ?M)." No hemolysis information or data found in the reference(s) presented in this entry Cyclic No specific N-terminal No specific C-terminal "The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl" "Mixed(D-Ala7,D-meth-Ala2)" [Ref.32376613]Vero E6 cells:CC50>20?M. Not found 32376613##32568027 Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00876-20. ##J Gen Virol. 2020 Sep;101(9):925-940. "Softic L, Brillet R, Berry F, Ahnou N, Nevers Q, Morin-Dewaele M, Hamadat S, Bruscella P, Fourati S, Pawlotsky JM, Ahmed-Belkacem A.##Ogando NS, Dalebout TJ, Zevenhoven-Dobbe JC, Limpens RWAL, van der Meer Y, Caly L, Druce J, de Vries JJC, Kikkert M, Brcena M, Sidorov I, Snijder EJ." "Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025).##SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology." DRAMP29234 PxTXXLPX 8 "Plitidepsin, Aplidine" No entry found Not found Not found Synthetic construct "Antimicrobial, Antiviral(SARS-CoV-2)" Not found Not found Not found None Mechanism of action:The antiviral activity of plitidepsin against SARS-CoV-2 is mediated through inhibition of the known target eEF1A (eukaryotic translation elongation factor 1A). "[Ref.33495306]Virus:SARS-CoV-2:inhibition of replication In Vero E6 cells(IC50=0.70 nM,IC90=1.76 nM);inhibition of replication In hACE2-HEK293T cells(IC50=0.73 nM,IC90=0.88 nM);inhibition of replication In pneumocyte-like cells(IC50=1.62 nM,IC90=3.14 nM).##[Ref.35231500]Virus:##SARS-CoV-2 D614G:inhibition of replication in Vero E6 cells(IC50=5.2 nM);##SARS-CoV-2 Delta:inhibition of replication in Vero E6 cells(IC50=3.9 nM);##SARS-CoV-2 Omicron:inhibition of replication in Vero E6 cells(IC50=4.3 nM)." No hemolysis information or data found in the reference(s) presented in this entry Linear Pyruvoyl Free "The 'X' at position 2 is N-methylleucine,position 4 is 4-amino-3-hydroxy-5-methyl-Heptanoic acid, position 5 is Hydroxyisovalerylpropionyl, and position 8 is N-methyl-4-methyl-tyrosine.There is a Sidechain-Mainchain Bond between position 3 and 8." Mixed(D-meth-Leu2) "[Ref.33495306]Vero E6 cells:CC10=0.36 nM,CC50=1.99 nM;hACE2-293T cells:CC10=2.00 nM,CC50>200 nM;pneumocyte-like cells:CC10=20.88 nM,CC50=65.43 nM." Not found 35231500##33495306 Antiviral Res. 2022 Apr;200:105270.##Science. 2021 Feb 26;371(6532):926-931. "Sachse M, Tenorio R, Fernndez de Castro I, Mu?oz-Basagoiti J, Perez-Zsolt D, Ra?ch-Regu D, Rodon J, Losada A, Avils P, Cuevas C, Paredes R, Segals J, Clotet B, Vergara-Alert J, Izquierdo-Useros N, Risco C.##White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guilln MJ, Losada A, Avils P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, Garca-Sastre A. " Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis.##Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. DRAMP00828 GLPTCGETCFGGTCNTPGCTCDPWPVCTHN 30 Cycloviolacin-O24 (Plant defensin) P84637 Belongs to the cyclotide family. Bracelet subfamily. Not found Viola odorata (Sweet violet) "Antiviral,Insecticidal " Protein level Bridge Not found None "Function: Probably participates in a plant defense mechanism. Has hemolytic activity. PTM: This is a cyclic peptide which may contain three disulfide bonds 5-19; 9-21; 14-27." [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=308 nM). [Ref:16872274] It has 75% hemolytic activity at 25.0 M against human type A red blood cells. Cyclic Cyclization (N termini to C termini) Cyclization (N termini to C termini) Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys27. L [Ref.18008336]CEM-SS cells:IC50=6170 nM. Not found 16872274##18008336 Biochem J. 2006 Nov 15;400(1):1-12.##Biopolymers. 2008;90(1):51-60. "Ireland DC, Colgrave ML, Craik DJ.##Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. " "A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.##Cyclotides as natural anti-HIV agents."