• • DRAMP ID

  • DRAMP01091

• • Peptide Name

  • Alyteserin-2Mb (toads, amphibians, animals)

• • Source

  • Alytes maurus (Midwife toad)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • ILGAIIPLVSGLLSHL

• • Sequence Length

  • 16

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@H](C)CC)[C@H](C)CC

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

• • Target Organism

  • • Gram-positive bacterium:

      Target Organism	Activity
      Staphylococcus aureus NCTC 10788	MIC=19.3 µM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • α-Amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP01091.

DRAMP01091

• • Function

  • Has antibacterial activity against the Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 310 microM.

• ·Literature 1

• • Title

  • Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions.

• • Pubmed ID

  • 22800568

• • Reference

  • Toxicon. 2012 Nov;60(6):967-981.

• • Author

  • König E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C.