General Information

    • DRAMP ID

    • DRAMP01182

    • Peptide Name

    • Ocellatin-P1 (Pentadactylin; Frogs, amphibians, animals)

    • Source

    • Leptodactylus pentadactylus (South American bullfrog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLDTLKGAAKNVVGSLASKVMEKL

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)[C@@H](C)O)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(N)=O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC 25922MIC=25 µM
        Klebsiella pneumoniae KK3 9904MIC=100 µM
        Enterobacter cloacae HNTCC 53001MIC=50 µM
        Pseudomonas aeruginosa ATCC 27853 (MIC=100 µM);-
      • Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus epidermidis RP62AMIC=100 µM
        Streptococcus Group B HNTCC 80130MIC=50 µM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01182.

Physicochemical Information

    • Formula

    • C112H200N30O34S

    • Absent Amino Acids

    • CFHIPQRWY

    • Common Amino Acids

    • L

    • Mass

    • 2543.06

    • PI

    • 9.53

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • -6.42

    • Hydrophobicity

    • 0.372

    • Aliphatic Index

    • 124.8

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP01182

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Pentadactylin: an antimicrobial peptide from the skin secretions of the South American bullfrog Leptodactylus pentadactylus.

    • Reference

    • Comp Biochem Physiol C Toxicol Pharmacol. 2005 Aug;141(4):393-397.

    • Author

    • King JD, Al-Ghaferi N, Abraham B, Sonnevend A, Leprince J, Nielsen PF, Conlon JM.