General Information

    • DRAMP ID

    • DRAMP01184

    • Peptide Name

    • SPX(1-22)(truncated peptide of Syphaxin; Frogs, amphibians, animals)

    • Source

    • Leptodactylus syphax (Burgundy thin-toed frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVLDILKGAAKDLAGHVATKVI

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O)C(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CN)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](C)CC)C(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium:
        Target OrganismActivity
        Staphylococcus aureus ATCC 29213 (MIC=14.6 µM);-
      • Gram-negative bacterium:
        Target OrganismActivity
        Escherichia coli ATCC 25922MIC=40.5 µM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01184.

Physicochemical Information

    • Formula

    • C99H173N27O28

    • Absent Amino Acids

    • CEFMNPQRSWY

    • Common Amino Acids

    • A

    • Mass

    • 2189.63

    • PI

    • 8.51

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • 5.46

    • Hydrophobicity

    • 0.746

    • Aliphatic Index

    • 146.36

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01184

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax.

    • Reference

    • Toxicon. 2007 Sep 15;50(4):572-580.

    • Author

    • Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F.