General Information

    • DRAMP ID

    • DRAMP01195

    • Peptide Name

    • Andersonin-D1 (Frogs, amphibians, animals)

    • Source

    • Odorrana andersonii (Golden crossband frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FIFPKKNIINSLFGR

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@H](C)CC

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC 25922MIC>126 µg/ml
        Bacillus pyocyaneus CMCCB 10104 (MIC=16 µg/ml);-
      • Gram-positive bacterium:
        Target OrganismActivity
        Staphylococcus aureus ATCC 25923MIC=16 µg/ml
      • Yeast:
        Target OrganismActivity
        Candida albicans ATCC 2002MIC=16 µg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01195.

Physicochemical Information

    • Formula

    • C87H136N22O19

    • Absent Amino Acids

    • ACDEHMQTVWY

    • Common Amino Acids

    • FI

    • Mass

    • 1794.17

    • PI

    • 11.17

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • -13.14

    • Hydrophobicity

    • 0.24

    • Aliphatic Index

    • 104

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01195

Comments Information

    • Function

    • Weakly active against bacteria and fungi. Andersonin-D1 showes obvious insulin-stimulating activity at the concentration of 50 μg/mL.

Literature Information

  • ·Literature 1

    • Title

    • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.

    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.

    • Author

    • Yang X, Lee WH, Zhang Y.