General Information

    • DRAMP ID

    • DRAMP01202

    • Peptide Name

    • Fallaxidin 3.2 (Frogs, amphibians, animals)

    • Source

    • Litoria fallax (Eastern dwarf tree frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLDFAKHVIGIASKLG

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)[C@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria:
        Target OrganismActivity
        Enterococcus faecalisMIC=100 µM
        Lactococcus lactisMIC=500 µM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01202.

Physicochemical Information

    • Formula

    • C81H135N21O21

    • Absent Amino Acids

    • CEMNPQRTWY

    • Common Amino Acids

    • GL

    • Mass

    • 1739.09

    • PI

    • 8.6

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 10.18

    • Hydrophobicity

    • 0.853

    • Aliphatic Index

    • 143.53

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01202

Comments Information

    • Function

    • Fallaxidin-3.2 shows antibacterial activity against the Gram-positive bacteria.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins.

    • Reference

    • Rapid Commun Mass Spectrom. 2008 Oct;22(20):3207-3216.

    • Author

    • Jackway RJ, Bowie JH, Bilusich D, Musgrave IF, Surinya-Johnson KH, Tyler MJ, Eichinger PC.