General Information

    • DRAMP ID

    • DRAMP01288

    • Peptide Name

    • Phylloseptin-1 (PSN-1; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa sauvagei (Sauvage's leaf frog)

    • Family

    • Not found

    • Gene

    • PSN-1

    • Sequence

    • FLSLIPHIVSGVASIAKHF

    • Sequence Length

    • 19

    • Protein Existence

    • Homology

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)[C@H](C)CC)[C@H](C)CC)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • S. aureus (MIC=5 µM), Escherichia coli and Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01288.

Physicochemical Information

    • Formula

    • C98H154N24O23

    • Absent Amino Acids

    • CDEMNQRTWY

    • Common Amino Acids

    • IS

    • Mass

    • 2036.45

    • PI

    • 8.76

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • 18.13

    • Hydrophobicity

    • 1.263

    • Aliphatic Index

    • 143.68

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01288

Comments Information

    • Function

    • PSN-1 displayed broad-spectrum activity against a range of planktonic organisms.

Literature Information

  • ·Literature 1

    • Title

    • Phylloseptin-1 (PSN-1) from Phyllomedusa sauvagei skin secretion: a novel broad-spectrum antimicrobial peptide with antibiofilm activity.

    • Reference

    • Mol Immunol. 2010 Jul;47(11-12):2030-2037.

    • Author

    • Zhang R, Zhou M, Wang L, McGrath S, Chen T, Chen X, Shaw C.